Peng Lee

Biosketch / Results /

Peng Lee

Professor, Department of Pathology
Professor, Department of Urology


Contact Info

212-951-3418
Peng.Lee@nyumc.org


Education

— NYU LMC, Residency Training
— MD Anderson Cancer Center, Clinical Fellowships
— Peking Univ SOM, Medical Education

Research Summary

The principal research focus of our group is to elucidate the molecular mechanism of hormonal (androgen and estrogen) receptors, their cofactors, and their target genes in the development of endocrine organs and malignancies, including breast and prostate cancers. In particular, we are interested in understanding the molecular mechanisms underlying the development of androgen-independent prostate cancer. A compelling element of our research is to understand how the expression and function of proteins in the stromal androgen receptor (AR) pathway influences the stromal-epithelial interactions, contributing to tumorigenesis. The long term goal of the lab is to apply these findings to clinically relevant issues; to identify prognostic or predictive biomarkers, and to discover novel therapeutic strategies for these cancers.

Research Keywords

cancer, Androgen receptor and its cofactors and target genes in prostate and breast cancer

Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea pigs
Fabris, Frank; Yue, Yunkun; Qu, Yongxia; Chahine, Mohamed; Sobie, Eric; Lee, Peng; Wieczorek, Rosemary; Jiang, Xian-Cheng; Capecchi, Pier-Leopoldo; Laghi-Pasini, Franco; Lazzerini, Pietro-Enea; Boutjdir, Mohamed. Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea pigs. Journal of physiology. 2016 Nov 01;594(21):6175-6187 (2145032)

Nuclear TBLR1 as an ER corepressor promotes cell proliferation, migration and invasion in breast and ovarian cancer
Wu, Xinyu; Zhan, Yang; Li, Xin; Wei, Jianjun; Santiago, Larion; Daniels, Garrett; Deng, Fangming; Zhong, Xuelin; Chiriboga, Luis; Basch, Ross; Xiong, Sheng; Dong, Yan; Zhang, Xinmin; Lee, Peng. Nuclear TBLR1 as an ER corepressor promotes cell proliferation, migration and invasion in breast and ovarian cancer. American journal of cancer research. 2016 Oct 1;6(10):2351-2360 (2303712)

Modification of the pT2 substage classification in prostate adenocarcinoma
Ettel, Mark; Kong, Max; Lee, Peng; Zhou, Ming; Melamed, Jonathan; Deng, Fang-Ming. Modification of the pT2 substage classification in prostate adenocarcinoma. Human pathology. 2016 Oct;56:57-63 (2125152)

Interplay Between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediate Castration Resistance
Dong, Yan; Zhan, Yang; Zhang, Guanyi; Wang, Xiaojie; Qi, Yangfeng; Bai, Shanshan; Li, Dongyi; Ma, Tianfang; Sartor, Oliver; Flemington, Erik K; Zhang, Haitao; Lee, Peng. Interplay Between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediate Castration Resistance. Molecular cancer research. 2016 Sep 26;15(1):59-68 (2262282)

Breast cancer molecular subtypes: from TNBC to QNBC
Hon, Jane Date C; Singh, Baljit; Sahin, Aysegul; Du, Gang; Wang, Jinhua; Wang, Vincent Y; Deng, Fang-Ming; Zhang, David Y; Monaco, Marie E; Lee, Peng. Breast cancer molecular subtypes: from TNBC to QNBC. American journal of cancer research. 2016 Sep 1;6(9):1864-1872 (2278302)