Peng Lee

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Peng Lee

Professor, Department of Pathology;Professor, Department of Urology

Contact Info



— NYU LMC, Residency Training
— MD Anderson Cancer Center, Clinical Fellowships
— Peking Univ SOM, Medical Education

Research Summary

The principal research focus of our group is to elucidate the molecular mechanism of hormonal (androgen and estrogen) receptors, their cofactors, and their target genes in the development of endocrine organs and malignancies, including breast and prostate cancers. In particular, we are interested in understanding the molecular mechanisms underlying the development of androgen-independent prostate cancer. A compelling element of our research is to understand how the expression and function of proteins in the stromal androgen receptor (AR) pathway influences the stromal-epithelial interactions, contributing to tumorigenesis. The long term goal of the lab is to apply these findings to clinically relevant issues; to identify prognostic or predictive biomarkers, and to discover novel therapeutic strategies for these cancers.

Research Interests

Androgen receptor and its cofactors in prostate and breast cancer |Androgen receptor,its cofactors and its target genes in prostate and breast development and cancer

BRD4 Inhibitor Inhibits Colorectal Cancer Growth and Metastasis
Hu, Yuan; Zhou, Jieqiong; Ye, Fei; Xiong, Huabao; Peng, Liang; Zheng, Zihan; Xu, Feihong; Cui, Miao; Wei, Chengguo; Wang, Xinying; Wang, Zhongqiu; Zhu, Hongfa; Lee, Peng; Zhou, Mingming; Jiang, Bo; Zhang, David Y
2015-01-26; 1422-0067,International journal of molecular sciences - id: 1441132, year: 2015 Journal Article

Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome
Leach, Damien A; Need, Eleanor F; Toivanen, Roxanne; Trotta, Andrew P; Palenthorpe, Helen M; Tamblyn, David J; Kopsaftis, Tina; England, Georgina M; Smith, Eric; Drew, Paul A; Pinnock, Carole B; Lee, Peng; Holst, Jeff; Risbridger, Gail P; Chopra, Samarth; DeFranco, Donald B; Taylor, Renea A; Buchanan, Grant
2015-05-13; 1949-2553,Oncotarget - id: 1570242, year: 2015 JOURNAL ARTICLE

LEF1 targeting EMT in prostate cancer invasion is mediated by miR-181a
Liang, Jiaqian; Li, Xin; Li, Yirong; Wei, Jianjun; Daniels, Garrett; Zhong, Xuelin; Wang, Jinhua; Sfanos, Karen; Melamed, Jonathan; Zhao, Jun; Lee, Peng
2015-06-07; 2156-6976,American journal of cancer research - id: 1615932, year: 2015 Journal Article

LEF1 Targeting EMT in Prostate Cancer Invasion is Regulated by miR-34a
Liang, Jiaqian; Li, Yirong; Daniels, Garrett; Sfanos, Karen; De Marzo, Angelo; Wei, Jianjun; Li, Xin; Cheng, Wenqiang; Wang, Jinhua; Zhong, Xuelin; Melamed, Jonathan; Zhao, Jun; Lee, Peng
2015-05-13; 1541-7786,Molecular cancer research - id: 1441592, year: 2015 JOURNAL ARTICLE

AR-V7, a Splicing Variant of Androgen Receptor, Is Upregulated in High-Grade Urothelial Carcinomav
Liu, Xichun; Cheng, Liang; Zhan, Yang; Dong, Yan; Kong, Max; Zhou, Ming; Melamed, Jonathan; Zhang, Haitao; Lee, Peng; Deng, Fang-Ming
2015-03-13; 1530-0307,Laboratory investigation - id: 1486982, year: 2015