Sylvia Lee Huang

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Sylvia Lee Huang, Ph.D.

Professor;
Department of Biochemistry and Molecular Pharmacology

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Education

— Univeristy of Pittsburgh, Graduate Education
1961-1962 — University of Pittsburgh, PostDoctoral Training
1962-1964 — Sloan Kettering Institute for Cancer Research, Chemical Physics, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Live-Cell Real-Time Imaging of Mitochondria in HIV-1-Infected Cells
Lee-Huang, Sylvia; Huang, Philip Lin; Huang, Paul Lee
2014 Oct;:548-550, AIDS research & human retroviruses
— id: 1283092, year: 2014, vol: , page: 548, stat: Journal Article,

Computational study of bindings of HL9, a nonapeptide fragment of human lysozyme, to HIV-1 fusion protein gp41
Hartono, Yossa Dwi; Lee, Angelina Noviani; Lee-Huang, Sylvia; Zhang, Dawei
2011 Mar 15;21(6):1607-1611, Bioorganic & medicinal chemistry letters
— id: 134121, year: 2011, vol: 21, page: 1607, stat: Journal Article,

Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1
Lee-Huang, Sylvia; Lin Huang, Philip; Lee Huang, Paul
2011 Nov 18;415(2):384-389, Biochemical & biophysical research communications
— id: 141703, year: 2011, vol: 415, page: 384, stat: Journal Article,

A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions
Li, Hui-Guang; Huang, Philip L; Zhang, Dawei; Sun, Yongtao; Chen, Hao-Chia; Zhang, John; Huang, Paul L; Kong, Xiang-Peng; Lee-Huang, Sylvia
2010 Jan 1;391(1):340-345, Biochemical & biophysical research communications
— id: 106367, year: 2010, vol: 391, page: 340, stat: Journal Article,

COMPUTATIONAL DESIGN OF NORBORNANE-BASED HIV-1 PROTEASE INHIBITORS
Zhang, DW; Yu, LZ; Huang, PL; Lee-Huang, S; Zhang, JZH
2010 APR ;9(2):471-485, Journal of theoretical & computational chemistry
— id: 110854, year: 2010, vol: 9, page: 471, stat: Journal Article,

Enos S1177 phosphorylation mediates metabolic energy expenditure and insulin sensitivity in knockin mice
Huang, P; Kashiwagi, S; Atochin, D; Li, Q; Schleicher, M; Earle, J; Pong, T; Lee-Huang, S; Moncada, S; Sessa, W
2009 JUN ;20(3):S36-S36, Nitric oxide : biology & chemistry
— id: 100525, year: 2009, vol: 20, page: S36, stat: Journal Article,

Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41
Bao, J; Zhang, DW; Zhang, JZH; Huang, PL; Huang, PL; Lee-Huang, S
2007 JUN 12 ;581(14):2737-2742, FEBS letters
— id: 73048, year: 2007, vol: 581, page: 2737, stat: Journal Article,

Erratum to ""Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition"" [Biochem. Biophys. Res. Commun. 354 (2007) 872-878] (DOI:10.1016/j.bbrc.2007.01.071)
Lee-Huang, S; Huang, PL; Zhang, D; Lee, JW; Bao, J; Sun, Y; Chang, Y-T; Zhang, J; Huang, PL
2007 ;356(4):1068-, Biochemical & biophysical research communications
— id: 643782, year: 2007, vol: 356, page: 1068, stat: Journal Article,

Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition
Lee-Huang, Sylvia; Huang, Philip Lin; Zhang, Dawei; Lee, Jae Wook; Bao, Ju; Sun, Yongtao; Chang, Young-Tae; Zhang, John; Huang, Paul Lee
2007 Mar 23;354(4):872-878, Biochemical & biophysical research communications
— id: 71018, year: 2007, vol: 354, page: 872, stat: Journal Article,

Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part II. Integrase inhibition
Lee-Huang, Sylvia; Huang, Philip Lin; Zhang, Dawei; Lee, Jae Wook; Bao, Ju; Sun, Yongtao; Chang, Young-Tae; Zhang, John; Huang, Paul Lee
2007 Mar 23;354(4):879-884, Biochemical & biophysical research communications
— id: 71019, year: 2007, vol: 354, page: 879, stat: Journal Article,

Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment
Lee-Huang, Sylvia; Zhang, Li; Huang, Philip Lin; Chang, Young-Tae; Huang, Paul L
2003 Aug 8;307(4):1029-1037, Biochemical & biophysical research communications
— id: 39130, year: 2003, vol: 307, page: 1029, stat: Journal Article,

Production of antiviral and antitumor proteins MAP30 and GAP31 in cucurbits using the plant virus vector ZYMV-AGII
Arazi, Tzahi; Lee Huang, Paul; Huang, Philip Lin; Zhang, Li; Moshe Shiboleth, Yoel; Gal-On, Amit; Lee-Huang, Sylvia
2002 Mar 29;292(2):441-448, Biochemical & biophysical research communications
— id: 95807, year: 2002, vol: 292, page: 441, stat: Journal Article,

Anti-hiv agent map30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in aids-related lymphoma cells infected with kaposi's sarcoma-associated virus
Sun Y; Huang PL; Li JJ; Huang YQ; Zhang L; Huang PL; Lee-Huang S
2001 Oct 5;287(4):983-994, Biochemical & biophysical research communications
— id: 24773, year: 2001, vol: 287, page: 983, stat: Journal Article,

Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30
Lee-Huang S; Huang PL; Sun Y; Chen HC; Kung HF; Huang PL; Murphy WJ
2000 Mar-Apr;20(2A):653-659, Anticancer research
— id: 11699, year: 2000, vol: 20, page: 653, stat: Journal Article,

In search of novel anti-HIV agents
Sylvia, Lee-Huang; Hao-Chia, Chen
2000 Oct 09;7(2):170-170, Journal of biomedical science
— id: 15767, year: 2000, vol: 7, page: 170, stat: Journal Article,

Anti-HIV and anti-tumor protein MAP30, a 30 kDa single-strand type-I RIP, shares similar secondary structure and beta-sheet topology with the A chain of ricin, a type-II RIP
Wang YX; Jacob J; Wingfield PT; Palmer I; Stahl SJ; Kaufman JD; Huang PL; Huang PL; Lee-Huang S; Torchia DA
2000 Jan;9(1):138-144, Protein science
— id: 15094, year: 2000, vol: 9, page: 138, stat: Journal Article,

Proteolytic fragments of anti-HIV and anti-tumor proteins MAP30 and GAP31 are biologically active
Huang PL; Sun Y; Chen HC; Kung HF; Lee-Huang S
1999 Sep 7;262(3):615-623, Biochemical & biophysical research communications
— id: 8486, year: 1999, vol: 262, page: 615, stat: Journal Article,

Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin
Lee-Huang S; Huang PL; Sun Y; Huang PL; Kung HF; Blithe DL; Chen HC
1999 Mar 16;96(6):2678-2681, Proceedings of the National Academy of Sciences of the United States of America
— id: 8505, year: 1999, vol: 96, page: 2678, stat: Journal Article,

The antiviral agents, MAP30 and GAP31, are not toxic to human spermatozoa and may be useful in preventing the sexual transmission of human immunodeficiency virus type 1
Schreiber CA; Wan L; Sun Y; Lu L; Krey LC; Lee-Huang S
1999 Oct;72(4):686-690, Fertility & sterility
— id: 11946, year: 1999, vol: 72, page: 686, stat: Journal Article,

Measurement of 3hJNC' connectivities across hydrogen bonds in a 30 kDa protein
Wang YX; Jacob J; Cordier F; Wingfield P; Stahl SJ; Lee-Huang S; Torchia D; Grzesiek S; Bax A
1999 Jun;14(2):181-184, Journal of biomolecular NMR
— id: 15096, year: 1999, vol: 14, page: 181, stat: Journal Article,

Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions
Wang YX; Neamati N; Jacob J; Palmer I; Stahl SJ; Kaufman JD; Huang PL; Huang PL; Winslow HE; Pommier Y; Wingfield PT; Lee-Huang S; Bax A; Torchia DA
1999 Nov 12;99(4):433-442, Cell
— id: 15095, year: 1999, vol: 99, page: 433, stat: Journal Article,

The activity of plant-derived antiretroviral proteins MAP30 and GAP31 against herpes simplex virus in vitro
Bourinbaiar AS; Lee-Huang S
1996 Feb 27;219(3):923-929, Biochemical & biophysical research communications
— id: 8056, year: 1996, vol: 219, page: 923, stat: Journal Article,

Protective effect of interferon-alpha against cell-mediated human immunodeficiency virus transmission resulting from coculture of infected lymphocytes with fetal trophoblasts
Bourinbaiar AS; Krasinski K; Borkowsky W; Lee-Huang S
1995 Jun;15(6):503-508, Journal of interferon & cytokine research
— id: 6582, year: 1995, vol: 15, page: 503, stat: Journal Article,

Acrosin inhibitor, 4'-acetamidophenyl 4-guanidinobenzoate, an experimental vaginal contraceptive with anti-HIV activity
Bourinbaiar AS; Lee-Huang S
1995 May;51(5):319-322, Contraception
— id: 6809, year: 1995, vol: 51, page: 319, stat: Journal Article,

Anti-HIV effect of beta subunit of human chorionic gonadotropin (beta hCG) in vitro
Bourinbaiar AS; Lee-Huang S
1995 Jan;44(1):13-18, Immunology letters
— id: 7893, year: 1995, vol: 44, page: 13, stat: Journal Article,

Potentiation of anti-HIV activity of anti-inflammatory drugs, dexamethasone and indomethacin, by MAP30, the antiviral agent from bitter melon
Bourinbaiar AS; Lee-Huang S
1995 Mar 17;208(2):779-785, Biochemical & biophysical research communications
— id: 6584, year: 1995, vol: 208, page: 779, stat: Journal Article,

Rational problems associated with the development of cellular approaches in controlling HIV spread
Bourinbaiar AS; Lee-Huang S
1995 ;374:71-89, Advances in experimental medicine & biology
— id: 8055, year: 1995, vol: 374, page: 71, stat: Journal Article,

The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication
Bourinbaiar AS; Lee-Huang S
1995 Feb 20;360(1):85-88, FEBS letters
— id: 6583, year: 1995, vol: 360, page: 85, stat: Journal Article,

Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon
Lee-Huang S; Huang PL; Chen HC; Huang PL; Bourinbaiar A; Huang HI; Kung HF
1995 Aug 19;161(2):151-156, Gene
— id: 6839, year: 1995, vol: 161, page: 151, stat: Journal Article,

Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti-HIV plant proteins MAP30 and GAP31
Lee-Huang S; Huang PL; Huang PL; Bourinbaiar AS; Chen HC; Kung HF
1995 Sep 12;92(19):8818-8822, Proceedings of the National Academy of Sciences of the United States of America
— id: 12732, year: 1995, vol: 92, page: 8818, stat: Journal Article,

Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol
Bourinbaiar AS; Lee-Huang S
1994 Feb;49(2):131-137, Contraception
— id: 6329, year: 1994, vol: 49, page: 131, stat: Journal Article,

Anti-HIV effect of immunomodulating agent, levamisole, in vitro
Bourinbaiar AS; Lee-Huang S; Krasinski K; Borkowsky W
1994 ;48(7):327-330, Biomedicine & pharmacotherapy
— id: 6585, year: 1994, vol: 48, page: 327, stat: Journal Article,

Inhibitory effect of the oral immune response modifier, bestatin, on cell-mediated and cell-free HIV infection in vitro
Bourinbaiar AS; Lee-Huang S; Krasinski K; Borkowsky W
1994 ;48(2):55-61, Biomedicine & pharmacotherapy
— id: 6586, year: 1994, vol: 48, page: 55, stat: Journal Article,

Crystallization and preliminary X-ray analysis of GAP 31. A protein which inhibits the life cycle of HIV-1
Lee-Huang S; Kung HF; Chen HC; Huang PL; Rybak SM; Huang PL; Bourinbaiar AS; Musayev F; Liaw YC
1994 Jul 1;240(1):92-94, Journal of molecular biology
— id: 12955, year: 1994, vol: 240, page: 92, stat: Journal Article,

Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31
Lee-Huang S; Kung HF; Huang PL; Bourinbaiar AS; Morell JL; Brown JH; Huang PL; Tsai WP; Chen AY; Huang HI
1994 Dec 6;91(25):12208-12212, Proceedings of the National Academy of Sciences of the United States of America
— id: 8447, year: 1994, vol: 91, page: 12208, stat: Journal Article,

Immune response in mice that lack the interferon-gamma receptor [see comments]
Huang S; Hendriks W; Althage A; Hemmi S; Bluethmann H; Kamijo R; Vilcek J; Zinkernagel RM; Aguet M
1993 Mar 19;259(5102):1742-1745, Science
— id: 15535, year: 1993, vol: 259, page: 1742, stat: Journal Article,

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide
Kamijo R; Le J; Shapiro D; Havell EA; Huang S; Aguet M; Bosland M; Vilcek J
1993 Oct 1;178(4):1435-1440, Journal of experimental medicine
— id: 13065, year: 1993, vol: 178, page: 1435, stat: Journal Article,

Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor
Kamijo R; Shapiro D; Le J; Huang S; Aguet M; Vilcek J
1993 Jul 15;90(14):6626-6630, Proceedings of the National Academy of Sciences of the United States of America
— id: 13105, year: 1993, vol: 90, page: 6626, stat: Journal Article,

The 3' flanking region of the human erythropoietin-encoding gene contains nitrogen-regulatory/oxygen-sensing consensus sequences and tissue-specific transcriptional regulatory elements
Lee-Huang S; Lin JJ; Kung HF; Huan PL; Lee L; Huang PL
1993 Dec 31;137(2):203-210, Gene
— id: 8351, year: 1993, vol: 137, page: 203, stat: Journal Article,

The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5' flanking region
Lee-Huang S; Lin JJ; Kung HF; Huang PL; Lee L; Huang PL
1993 Jun 30;128(2):227-236, Gene
— id: 13126, year: 1993, vol: 128, page: 227, stat: Journal Article,

Anti-HIV plant proteins catalyze topological changes of DNA into inactive forms
Huang PL; Chen HC; Kung HF; Huang PL; Huang P; Huang HI; Lee-Huang S
1992 Dec;4(1):37-41, Biofactors
— id: 15097, year: 1992, vol: 4, page: 37, stat: Journal Article,

TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells
Lee-Huang S; Huang PL; Kung HF; Li BQ; Huang PL; Huang P; Huang HI; Chen HC
1991 Aug 1;88(15):6570-6574, Proceedings of the National Academy of Sciences of the United States of America
— id: 13958, year: 1991, vol: 88, page: 6570, stat: Journal Article,

A new class of anti-HIV agents: GAP31, DAPs 30 and 32
Lee-Huang S; Kung HF; Huang PL; Huang PL; Li BQ; Huang P; Huang HI; Chen HC
1991 Oct 7;291(1):139-144, FEBS letters
— id: 13867, year: 1991, vol: 291, page: 139, stat: Journal Article,

MAP 30: a new inhibitor of HIV-1 infection and replication
Lee-Huang S; Huang PL; Nara PL; Chen HC; Kung HF; Huang P; Huang HI; Huang PL
1990 Oct 15;272(1-2):12-18, FEBS letters
— id: 14315, year: 1990, vol: 272, page: 12, stat: Journal Article,

Anti-erythropoietin antibodies in hyperviscosity syndrome associated with giant lymph node hyperplasia (GLNH; Castleman's disease)
Steinberg JJ; Huang PL; Ljubich P; Lee-Huang S
1990 Apr;74(4):543-544, British journal of haematology
— id: 15098, year: 1990, vol: 74, page: 543, stat: Journal Article,

Cloning and expression of human erythropoietin cDNA in Escherichia coli
Lee-Huang S
1984 May;81(9):2708-2712, Proceedings of the National Academy of Sciences of the United States of America
— id: 15099, year: 1984, vol: 81, page: 2708, stat: Journal Article,

A new preparative method for isolation of human erythropoietin with hydrophobic interaction chromatography
Lee-Huang S
1980 Oct;56(4):620-624, Blood
— id: 15100, year: 1980, vol: 56, page: 620, stat: Journal Article,

Isolation and characterization of proteoglycans from human chondrosarcomas
Pal S; Strider W; Margolis R; Gallo G; Lee-Huang S
1978 Feb 25;253(4):1279-1289, Journal of biological chemistry
— id: 15101, year: 1978, vol: 253, page: 1279, stat: Journal Article,

Eucaryotic oligonucleotides affecting mRNA translation
Lee-Huang S; Sierra JM; Naranjo R; Filipowicz W; Ochoa S
1977 Apr 30;180(2):276-287, Archives of biochemistry & biophysics. ABB
— id: 15102, year: 1977, vol: 180, page: 276, stat: Journal Article,

Inhibition of polypeptide chain initiation in Escherichia coli by elongation factor G
Lee-Huang S; Lee H; Ochoa S
1974 Aug;71(8):2928-2931, Proceedings of the National Academy of Sciences of the United States of America
— id: 15103, year: 1974, vol: 71, page: 2928, stat: Journal Article,

Preparation and properties of crystalline initiation factor 1 (IF1) from Escherichia coli
Lee-Huang S; Ochoa S
1974 ;30(0):31-39, Methods in enzymology
— id: 15105, year: 1974, vol: 30, page: 31, stat: Journal Article,

Purification of two messenger-discriminating species of initiation factor 3 (IF3) from Escherichia coli
Lee-Huang S; Ochoa S
1974 ;30(0):45-53, Methods in enzymology
— id: 15104, year: 1974, vol: 30, page: 45, stat: Journal Article,

A specific inhibitor of polypeptide-chain initiation in Escherichia coli
Lee-Huang S; Lee H; Ochoa S
1973 Oct;70(10):2874-2878, Proceedings of the National Academy of Sciences of the United States of America
— id: 15107, year: 1973, vol: 70, page: 2874, stat: Journal Article,

Purification and properties of two messenger-discriminating species of E. coli initiation factor 3
Lee-Huang S; Ochoa S
1973 May;156(1):84-96, Archives of biochemistry & biophysics. ABB
— id: 15108, year: 1973, vol: 156, page: 84, stat: Journal Article,

Factor requirements for initiation complex formation with natural and synthetic messengers in Escherichia coli systems
Meier D; Lee-Huang S; Ochoa S
1973 Dec 25;248(24):8613-8615, Journal of biological chemistry
— id: 15106, year: 1973, vol: 248, page: 8613, stat: Journal Article,

Specific inhibitors of MS2 and late T4 RNA translation in E. coli
Lee-Huang S; Ochoa S
1972 Oct 17;49(2):371-376, Biochemical & biophysical research communications
— id: 15109, year: 1972, vol: 49, page: 371, stat: Journal Article,

Messenger discriminating species of initiation factor F3
Lee-Huang, S; Ochoa, S
1971 Dec 22;234(51):236-239, Nature: new biology
— id: 15110, year: 1971, vol: 234, page: 236, stat: Journal Article,

Isolation and properties of crystalline initiation factor F1 from Escherichia coli ribosomes
Lee-Huang, S; Sillero, M A; Ochoa, S
1971 Feb;18(4):536-543, European journal of biochemistry
— id: 15111, year: 1971, vol: 18, page: 536, stat: Journal Article,

The preparation and properties of ribonucleic acid polymerase from Azotobacter vinelandii
Lee-Huang S; Warner RC
1969 Jul 25;244(14):3793-3802, Journal of biological chemistry
— id: 15112, year: 1969, vol: 244, page: 3793, stat: Journal Article,

Nucleic Acid Polymerases: Possible Subunit Structure
Lee-Huang S; Cavalieri LF
1965 Jun 11;148(3676):1474-1476, Science
— id: 95808, year: 1965, vol: 148, page: 1474, stat: Journal Article,

ISOLATION AND PROPERTIES OF A NUCLEIC ACID HYBRID POLYMERASE
LEE-HUNG, S; CAVALIERI, L F
1964 Jun;51:1022-1028, Proceedings of the National Academy of Sciences of the United States of America
— id: 111951, year: 1964, vol: 51, page: 1022, stat: Journal Article,

POLYRIBONUCLEOTIDES AS TEMPLATES FOR POLYDEOXYRIBONUCLEOTIDES
LEE-HUANG, S; CAVALIERI, L F
1963 Dec;50:1116-1122, Proceedings of the National Academy of Sciences of the United States of America
— id: 110398, year: 1963, vol: 50, page: 1116, stat: Journal Article,

Solubility of complexes of polynucleotides with spermine
HUANG, S L; FELSENFELD, G
1960 Oct 22;188:301-302, Nature
— id: 111952, year: 1960, vol: 188, page: 301, stat: Journal Article,