Jo-Ann M. Latkowski, M.D.

Poikilodermatous mycosis fungoides
Farley-Loftus, Rachel; Mandal, Rajni; Latkowski, Jo-Ann
2010 ;16(11):8-8, Dermatology online journal
Poikilodermatous mycosis fungoides is a rare form of cutaneous T-cell lymphoma that is characterized clinically by localized or diffuse patches, which consist of telangiectases, mottled hyper- and hypopigmentation, and atrophy. The immunophenotype of neoplastic cells is similar to that observed in classic mycosis fungoides. Therapeutic options used in poikilodermatous and classic mycosis fungoides include both skin-directed and systemic treatments. We present a case of poikilodermatous mycosis fungoides in a 53-year-old woman, who initially presented with erythroderma and who has failed multiple treatment modalities
— id: 115891, year: 2010, vol: 16, page: 8, stat: Journal Article,

Primary cutaneous anaplastic large-cell lymphoma
Newlove, Tracey; Loyd, Aaron; Patel, Rishi; Jelinek, Josef; Latkowski, Jo-Ann
2010 ;16(11):2-2, Dermatology online journal
Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease
— id: 115807, year: 2010, vol: 16, page: 2, stat: Journal Article,

Strategies for treating cutaneous T-cell lymphoma: part 1: remission
Latkowski, Jo-Ann; Heald, Peter
2009 Jun;2(6):22-27, Journal of Clinical & Aesthetic Dermatology
In this article, the management of cutaneous T-cell lymphoma will be presented in terms of the strategies that guide treatment. With the strategies and goals in mind, treatment options to achieve a measurable goal will be presented. The treatments presented in this article are those utilized to reliably achieve a remission. If remission is not achieved, a patient's management plan must be changed. The landmarks that help guide the therapy plan will be discussed
— id: 115890, year: 2009, vol: 2, page: 22, stat: Journal Article,

Pseudolymphoma evolving into diffuse large B-cell lymphoma
Anandasabapathy, Niroshana; Pulitzer, Melissa; Epstein, Wendy; Rosenman, Karla; Latkowski, Jo-Ann
2008 ;14(5):22-22, Dermatology online journal
A 46-year-old man presented with a 1-year history of asymptomatic papules on the right arm, without an antecedent event. Initial clinical and histopathologic features were consistent with a pseudolymphoma without gene rearrangements, and the patient was treated with intralesional glucocorticoids. Four months later, the patient developed additional papules and plaques on the right arm, and, at this time, clinical and histopathologic features were most consistent with a T-cell-rich, large B-cell lymphoma, with monoclonal immunoglobulin light chain gene rearrangement. Systemic evaluation showed no evidence of extracutaneous involvement. The transformation of a pseudolymphoma into a large B-cell lymphoma is a rare event. This patient's subtype, diffuse large B-cell lymphoma-other, carries an intermediate prognosis when compared to the more aggressive leg subtype and more indolent folliculocentric subtype. Potential therapeutic options include local radiotherapy, chemotherapy, and rituximab
— id: 81356, year: 2008, vol: 14, page: 22, stat: Journal Article,

Papular mucinosis (discrete papular lichen myxedematosus)
Bragg, Jennifer; Soldano, Anthony C; Latkowski, Jo-Ann M
2008 ;14(5):14-14, Dermatology online journal
A 56-year-old woman presented with small, skin-colored papules on the trunk and thighs. Histopathologic findings were consistent with papular mucinosis. Laboratory evaluation did not show an associated paraproteinemia. Treatment with topical glucocorticoids was unsuccessful. Papular mucinosis, also known as localized lichen myxedematosus, has been categorized into 4 subtypes. The discrete papular form, as seen in our patient, is characterized by a few to multiple, 2-5-mm, skin-colored, firm, waxy, dome-shaped papules on the trunk and proximal aspects of the extremities. By definition there is no associated paraproteinemia, but this form may be associated with human immunodeficiency virus infection. Focal or diffuse mucinous deposits are seen on histopathologic examination. The usual clinical course is slow cutaneous progression without spontaneous resolution. Treatment is empiric and is usually unsuccessful
— id: 95788, year: 2008, vol: 14, page: 14, stat: Journal Article,

Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
Furtado, Glaucia C; Marcondes, Maria Cecilia G; Latkowski, Jo-Ann; Tsai, Julia; Wensky, Allen; Lafaille, Juan J
2008 Oct 1;181(7):4648-4655, Journal of immunology
Strong evidence supports that CNS-specific CD4(+) T cells are central to the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Using a model of spontaneous EAE, we demonstrated that myelin basic protein (MBP)-specific CD4(+) T cells up-regulate activation markers in the CNS-draining cervical lymph nodes at a time when there is no T cell activation anywhere else, including the CNS, and before the appearance of clinical signs. In spontaneous EAE, the number of MBP-specific T cell numbers does not build up gradually in the CNS; instead, a swift migration of IFN-gamma-producing T cells into the CNS takes place approximately 24 h before the onset of neurological signs of EAE. Surgical excision of the cervical lymph nodes in healthy pre-EAE transgenic mice delayed the onset of EAE and resulted in a less severe disease. In EAE induced by immunization with MBP/CFA, a similar activation of T cells in the draining lymph nodes of the injection site precedes the disease. Taken together, our results suggest that peripheral activation of T cells in draining lymph nodes is an early event in the development of EAE, which paves the way for the initial burst of IFN-gamma-producing CD4(+) T cell into the CNS
— id: 91439, year: 2008, vol: 181, page: 4648, stat: Journal Article,

Successful therapy of cutaneous T-cell lymphoma
Heald P.; Latkowski J.-A.; Wilson L.D.; Mark L.A.
2008 ;3(1):99-110, Expert Review of Dermatology
Treatment objectives of cutaneous T-cell lymphoma can be achieved with a variety of modalities applied to the variable presentations of the disease. In this review, the goals of therapy are presented and each therapy is summarized in terms of its use to achieve those goals. After reviewing the modalities, the strategies are summarized in reference to each presentation of cutaneous T-cell lymphoma. copyright 2008 Future Drugs Ltd
— id: 76445, year: 2008, vol: 3, page: 99, stat: Journal Article,

Molecular origin of endemic leprosy in New York City
Keo, Thormika; Martiniuk, Frank; Latkowski, JoAnn; Cabrera, Aloys; Rom, William; Levis, William R
2008 Mar 15;46(6):899-901, Clinical infectious diseases
We report an indigenous case of leprosy in New York City in an immunocompetent patient who was infected with a Mycobacterium leprae genotype that is consistent with an exogenous origin. Physicians in the eastern United States should be alerted that, although most patients who develop leprosy in the United States are foreign born, native-born Americans are also susceptible to the infection
— id: 76393, year: 2008, vol: 46, page: 899, stat: Journal Article,

Anaplastic large-cell T-cell lymphoma
Stein, Jennifer A; Soldano, Anthony C; Latkowski, Jo-Ann M
2008 ;14(5):15-15, Dermatology online journal
A 64-year-old woman presented with 2 years of pruritic and ulcerated nodules and tumors on the trunk and arms. Histopathologic examination showed a diffuse infiltrate that consisted of predominantly small lymphocytes and scattered large atypical multinucleated cells positive for CD30. These findings were consistent with a diagnosis of anaplastic large-cell T-cell lymphoma, which is a CD30+ cutaneous lymphoma. This case highlights the importance of considering both histopathologic and clinical criteria in diagnosing a patient with a CD30+ cutaneous lymphoma
— id: 83991, year: 2008, vol: 14, page: 15, stat: Journal Article,

Efalizumab-associated Guillain-Barre syndrome
Victor, Frank; Menon, Kavita; Latkowski, Jo-Ann M; Fernandez-Obregon, Adolfo; Strober, Bruce E
2008 Oct;144(10):1396-1397, Archives of dermatology
— id: 94884, year: 2008, vol: 144, page: 1396, stat: Journal Article,

Mycosis fungoides with depigmentation secondary to treatment
Firoz, Bahar; Kovich, Olympia I; Latkowski, Jo-Ann M
2007 ;13(1):18-18, Dermatology online journal
A 51-year-old man presented with itchy, erythematous patches and plaques on his trunk, arms, and legs. A skin biopsy specimen showed mycosis fungoides. Initially the patient did not respond to PUVA photochemotherapy but later improved on NB-UVB phototherapy combined with bexarotene and interferon-alpha. The lesions progressed from erythematous patches and plaques to hyperpigmented patches with central depigmentation and localized areas of follicular repigmentation. The development of depigmentation after PUVA photochemotherapy for mycosis fungoides has been described in the literature and does not have associated prognostic implications. It is important to be cognizant of phototoxicity associated with PUVA photochemotherapy or NB-UVB phototherapy in patients with mycosis fungoides, who may be taking photosensitizing medications or have depigmented patches which renders them more sensitive to lower doses of ultraviolet light
— id: 94933, year: 2007, vol: 13, page: 18, stat: Journal Article,

Mycosis fungoides involving the nasal mucosa
Gruson, Lisa M; Heller, Patricia; Hemmerdinger, Steven A; Latkowski, Jo-Ann M
2007 May;56(5 Suppl):S112-S114, Journal of the American Academy of Dermatology
— id: 72621, year: 2007, vol: 56, page: S112, stat: Journal Article,

Folliculotropic mycosis fungoides
Hunzeker, Christopher M; Fangman, William; Latkowski, Jo-Ann M
2007 ;13(1):5-5, Dermatology online journal
A 72-year-old man presented with a 4-year history of asymptomatic erythematous plaques on his face, neck, and scalp. He had no systemic symptoms or lymphadenopathy. Histopathologic examination of a skin biopsy specimen showed a dense, diffuse infiltrate of lymphocytes and plasma cells, with epidermotropism and folliculotropism. T-cell receptor (TCR) gene rearrangement analysis performed on skin biopsy specimen showed a monoclonal cell population. A diagnosis of folliculotropic mycosis fungoides (MF) was made. This clinicopathologic variant of MF is usually associated with ordinary patch-plaque lesions. The prognosis of folliculotropic MF is best estimated using the TNM staging criteria. Many clinicians feel that this variant of MF portends a worse prognosis; however, there are no studies to support this idea. Folliculotropic MF may be more resistant to superficial therapies because of the depth of the neoplastic T-cells in the follicle
— id: 95789, year: 2007, vol: 13, page: 5, stat: Journal Article,

Frontal fibrosing alopecia
Clark-Loeser, Lesley; Latkowski, Jo-Ann
2005 ;11(4):6-6, Dermatology online journal
A 75-year-old woman presented with a 3-year history of progressive loss of her eyebrow hair and with frontal-parietal hairline recession. Multiple biopsy specimens supported a histopathologic diagnosis of lichen planopilaris. With these histolopathologic findings, and the patient's clinical presentation, a diagnosis of frontal fibrosing alopecia was made. Treatment to date with topical glucocorticoid preparations, intralesional triamcinolone injections, and tacrolimus ointment have been unsuccessful
— id: 66680, year: 2005, vol: 11, page: 6, stat: Journal Article,

Diffuse large cell non-Hodgkin's lymphoma, CD30+, T-cell phenotype
Gruson, Lisa Moed; Latkowski, Jo-Ann
2005 ;11(4):17-17, Dermatology online journal
A 63-year-old Chinese man presented with an eczematous dermatitis that progressed into a multifocal nodular eruption. Histopathologic examination demonstrated a nodular and diffuse infiltrate in the reticular dermis, which was composed of lymphocytes, macrophages with granulomatous inflammation, and numerous eosinophils. Reactive lymphoid follicles with germinal centers also were present. Immunohistochemistry showed CD30 and LCA. ALK-1 and CD20 were negative. A diagnosis of CD30+ cutaneous T-cell lymphoma was made, and the patient is currently undergoing staging of his disease. Treatment options include excision of nodules, radiation therapy, and systemic chemotherapy
— id: 66688, year: 2005, vol: 11, page: 17, stat: Journal Article,

Follicular mucinosis associated with mycosis fungoides
Clark-Loeser, Lesley; Latkowski, Jo-Ann
2004 ;10(3):22-22, Dermatology online journal
A 62-year-old man with a 13-year history of mycosis fungoides presented with a 2-month history of alopecia of the scalp. The mycosis fungoides had remained untreated for the previous 3.5 years. A biopsy specimen from the scalp showed follicular mucinosis in association with mycosis fungoides
— id: 115881, year: 2004, vol: 10, page: 22, stat: Journal Article,

Delta-like 4 in T cell lymphoma
Latkowski, JM; Lafaille, J
2004 MAR ;122(3):A20-A20, Journal of investigative dermatology
— id: 46572, year: 2004, vol: 122, page: A20, stat: Journal Article,

Removal of the deep cervical lymph nodes decreases the severity of EAE
Furtado, GC; Marcondes, MCG; Tsai, J; Latkowski, JA; Lafaille, JJ
2002 Mar 20;16(4):A715-A715, FASEB journal
— id: 27503, year: 2002, vol: 16, page: A715, stat: Journal Article,

Regulatory T cells in spontaneous autoimmune encephalomyelitis
Furtado GC; Olivares-Villagomez D; Curotto de Lafaille MA; Wensky AK; Latkowski JA; Lafaille JJ
2001 Aug;182(2):122-134, Immunological reviews
Spontaneous experimental autoimmune encephalomyelitis (EAE) develops in 100% of mice harboring a monoclonal myelin basic protein (MBP)-specific CD4+ alphabeta T-cell repertoire. Monoclonality of the alphabeta T-cell repertoire can be achieved by crossing MBP-specific T-cell receptor (TCR) transgenic mice with either RAG-/- mice or TCR alpha-/-/TCR beta-/- double knockout mice. Spontaneous EAE can be prevented by a single administration of purified CD4+ splenocytes or thymocytes obtained from wild-type syngeneic mice. The regulatory T cells (T-reg) that protect from spontaneous EAE need not express the CD25 marker, as effective protection can be attained with populations depleted of CD25+ T cells. Although the specificity of the regulatory T cells is important for their generation or regulatory function, T cells that protect from spontaneous EAE can have a diverse TCR alpha and beta chain composition. T-reg cells expand poorly in vivo, and appear to be long lived. Finally, precursors for T-reg are present in fetal liver as well as in the bone marrow of aging mice. We propose that protection of healthy individuals from autoimmune diseases involves several layers of regulation, which consist of CD4+CD25+ regulatory T cells, CD4+CD25- T-reg cells, and anti-TCR T cells, with each layer potentially operating at different stages of T-helper cell-mediated immune responses
— id: 32232, year: 2001, vol: 182, page: 122, stat: Journal Article,

Lymphocytic infiltrates
Rothfleisch J; Latkowski JA
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3721, year: 2001, vol: , page: 110, stat: Chapter,

Parapsoriasis
Rothfleisch J; Latkowski JA
Current dermatologic diagnosis & treatment Philadelphia : Lippincott Williams & Wilkins, 2001,
— id: 3735, year: 2001, vol: , page: 144, stat: Chapter,

Discussion of questions 1-7
Latkowski JA; Rico MJ
2000 May;42(5 Pt 1):855-858, Journal of the American Academy of Dermatology
— id: 17578, year: 2000, vol: 42, page: 855, stat: Journal Article,

Keratinocyte growth factor and keratin gene regulation
Latkowski JM; Freedberg IM; Blumenberg M
1995 Jan;9(1):36-44, Journal of dermatological science
Keratinocyte growth factor (KGF) is a stromally derived paracrine mitogen that belongs to the fibroblast growth factor (FGF) family. It is secreted by dermal fibroblasts and specifically promotes keratinocyte proliferation. We have recently shown that epidermal growth factor (EGF) and transforming growth factor beta (TGF beta), modulators of keratinocyte proliferation, regulate expression of specific keratin genes. However KGF, unlike EGF and TGF beta, allows keratinocytes to differentiate normally. With this in mind, we sought to determine whether KGF may be involved in keratinocyte differentiation through a mechanism that does not involve regulation of keratin gene expression. We transfected human epidermal keratinocytes with ten different keratin gene promoters linked to a reporter gene, and grew the transfected cells in the presence or absence of KGF. Interestingly, no significant change in keratin gene regulation was observed in the presence of KGF relative to control. The possibility that KGF influences the induction of keratin gene expression by other keratinocyte modulators, such as EGF, TGF beta and gamma interferon (IFN gamma), was also explored. In these experiments, the transformed keratinocytes were exposed simultaneously to KGF and another modulator. KGF did not significantly change the effects of EGF, TGF beta or IFN gamma on keratin gene expression. KGF's lack of ability to directly regulate keratin gene expression suggests that KGF affects keratinocyte growth and differentiation through a pathway independent of keratin gene regulation. These results illustrate that regulation of keratinocyte proliferation can be separated from the regulation of keratin gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)
— id: 6668, year: 1995, vol: 9, page: 36, stat: Journal Article,

KERATINOCYTE GROWTH-FACTOR AND KERATIN GENE-REGULATION
LATKOWSKI, JAM; KOMINE, M; FREEDBERG, IM; BLUMENBERG, M
1994 APR ;102(4):640-640, Journal of investigative dermatology
— id: 52349, year: 1994, vol: 102, page: 640, stat: Journal Article,