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Eric J Lang

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Eric J Lang, M.D., Ph.D.

Associate Professor; Co-Advisor Neuroscience Grd Pgm
Department of Physiology and Neuroscience (Phys/Neuro)

Contact Info

Address
550 First Avenue
Floor 4 Room 461
Medical Science Building
New York, NY 10016

Phone: 212-263-5410, 212-263-6638
Phone: 212-263-5410, 212-263-6638
Fax: 212-689-9060
Email: Eric.Lang@nyumc.org

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Education

1994 — New York University School of Medicine, Medical Education
— Laval University, PostDoctoral Training
1995 — New York University Graduate School of Arts and Sciences, Graduate Education

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Research Summary

The major focus of the laboratory is to investigate the neuronal basis of motor coordination. In particular, we are studying the relationship of the activity of two brain regions, the motor cortex and cerebellum, to movement.

The olivocerebellar system is one of the two major afferent systems to the cerebellum. This system is organized to generate patterns of rhythmic and synchronous activity, which evoke complex spike activity in cerebellar Purkinje cells. These periodic synchronous discharges are hypothesized to have a timing function that helps organize the activation of muscles to generate a movement. To observe the patterns of activity of the olivocerebellar system we employ a multiple electrode recording technique, which allows us to record simultaneously the complex spike activity from more than 100 Purkinje cells. We have been investigating the roles of excitatory and inhibitory inputs to the inferior olive in organizing these discharges. To do this we make pressure injections of GABAergic and glutamatergic antagonists into the inferior olive and investigate the resulting changes in the patterns of complex spike activity. We are also investigating how the motor cortex and olivocerebellar system interact to control the execution of a movement. The timing hypothesis suggests that the function of olivocerebellar activity may be to gate the ability of motor cortex activity to generate movements. That is, the olivocerebellar system may be helping determine the timing of descending motor commands from the cortex. To test this idea we are combining multiple electrode recording of complex spike activity with high speed videotaping of whisker movements evoked by motor cortex stimulation.

Research Interests

Neuronal basis of motor control, cerebellar physiology Neuronal basis of motor control, cerebellar physiology

Research Keywords

inferior olive, complex spike, motor cortex, GABA, motor coordination; inferior olive, complex spike, motor cortex, GABA, motor coordination

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity
Blenkinsop, Timothy A; Lang, Eric J
2011 Oct 12;31(41):14708-14720, Journal of neuroscience
— id: 138718, year: 2011, vol: 31, page: 14708, stat: Journal Article,

Control of cerebellar nuclear cells: a direct role for complex spikes?
Lang, Eric J; Blenkinsop, Timothy A
2011 Dec;10(4):694-701, Cerebellum
— id: 141482, year: 2011, vol: 10, page: 694, stat: Journal Article,

QUANTITATIVE MODELING OF SPATIO-TEMPORAL DYNAMICS OF INFERIOR OLIVE NEURONS WITH A SIMPLE CONDUCTANCE-BASED MODEL
Katori, Y; Lang, EJ; Onizuka, M; Kawato, M; Aihara, K
2010 MAR ;20(3):583-603, International journal of bifurcation & chaos in applied sciences & engineering
— id: 110857, year: 2010, vol: 20, page: 583, stat: Journal Article,

ALCOHOL-INDUCED REDUCTION OF PURKINJE CELL COMPLEX SPIKE SYNCHRONY. A POSSIBLE CAUSE OF ABNORMAL CEREBELLAR OUTPUT LEADING TO MOTOR INCOORDINATION
Lang, E. J.; Salah, A.
2010 JUN ;34(6):270A-270A, Alcoholism: clinical & experimental research
— id: 134679, year: 2010, vol: 34, page: 270A, stat: Journal Article,

Local changes in the excitability of the cerebellar cortex produce spatially restricted changes in complex spike synchrony
Marshall, Sarah P; Lang, Eric J
2009 Nov 11;29(45):14352-14362, Journal of neuroscience
— id: 105251, year: 2009, vol: 29, page: 14352, stat: Journal Article,

Testing a neural coding hypothesis using surrogate data
Hirata, Y; Katori, Y; Shimokawa, H; Suzuki, H; Blenkinsop, TA; Lang, EJ; Aihara, K
2008 JUL 30 ;172(2):312-322, Journal of neuroscience methods
— id: 86823, year: 2008, vol: 172, page: 312, stat: Journal Article,

Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform
Zagha, Edward; Lang, Eric J; Rudy, Bernardo
2008 Feb 6;28(6):1291-1300, Journal of neuroscience
— id: 76117, year: 2008, vol: 28, page: 1291, stat: Journal Article,

Altered olivocerebellar activity patterns in the connexin36 knockout mouse
Marshall SP; van der Giessen RS; de Zeeuw CI; Lang EJ
2007 Feb 28;:287-299, Cerebellum
— id: 140340, year: 2007, vol: , page: 287, stat: Journal Article,

Relationship of complex spike synchrony bands and climbing fiber projection determined by reference to aldolase C compartments in crus IIa of the rat cerebellar cortex
Sugihara, Izumi; Marshall, Sarah P; Lang, Eric J
2007 Mar;501(1):13-29, Journal of comparative neurology
— id: 163822, year: 2007, vol: 501, page: 13, stat: Journal Article,

Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and Rhythmicity
Blenkinsop, TA; Lang, EJ
2006 FEB 8 ;26(6):1739-1748, Journal of neuroscience
— id: 62539, year: 2006, vol: 26, page: 1739, stat: Journal Article,

Isochrony in the olivocerebellar system underlies complex spike synchrony
Lang, Eric J; Llinas, Rodolfo; Sugihara, Izumi
2006 May 15;573(Pt 1):277-9; author reply 281, Journal of physiology
— id: 95901, year: 2006, vol: 573, page: 277, stat: Journal Article,

Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat
Lang, Eric J; Sugihara, Izumi; Llinas, Rodolfo
2006 Feb 15;571(Pt 1):101-120, Journal of physiology
— id: 63833, year: 2006, vol: 571, page: 101, stat: Journal Article,

Cerebellum
Llinas, Rodolfo R; Walton, Kerry D; Lang, Eric J
The synaptic organization of the brain New York, NY, US: Oxford University Press, 2004,
— id: 4728, year: 2004, vol: , page: 271, stat: Chapter,

Inferior olive oscillations gate transmission of motor cortical activity to the cerebellum
Marshall, Sarah P; Lang, Eric J
2004 Dec 15;24(50):11356-11367, Journal of neuroscience
— id: 56088, year: 2004, vol: 24, page: 11356, stat: Journal Article,

Inhibitory control of rat lateral amygdaloid projection cells
Chen, J C T; Lang, E J
2003 ;121(1):155-166, Neuroscience
— id: 39096, year: 2003, vol: 121, page: 155, stat: Journal Article,

Excitatory afferent modulation of complex spike synchrony
Lang, Eric J
2003 ;2(3):165-170, Cerebellum
— id: 39056, year: 2003, vol: 2, page: 165, stat: Journal Article,

Role of myelination in the development of a uniform olivocerebellar conduction time
Lang, Eric J; Rosenbluth, Jack
2003 Apr;89(4):2259-2270, Journal of neurophysiology
— id: 39286, year: 2003, vol: 89, page: 2259, stat: Journal Article,

Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network
Pare, Denis; Royer, Sebastien; Smith, Yoland; Lang, Eric J
2003 Apr;985:78-91, Annals of the New York Academy of Sciences
— id: 66782, year: 2003, vol: 985, page: 78, stat: Journal Article,

GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity
Lang, Eric J
2002 Apr;87(4):1993-2008, Journal of neurophysiology
— id: 27409, year: 2002, vol: 87, page: 1993, stat: Journal Article,

Oscillatory properties of inferior olivary neurons modulate transmission of motor cortical activity to the rat cerebellum
Marshall, SP; Maxwell, KM; Lang, EJ
2002 FEB ;978(3):530-532, Annals of the New York Academy of Sciences
— id: 34097, year: 2002, vol: 978, page: 530, stat: Journal Article,

Organization of olivocerebellar activity in the absence of excitatory glutamatergic input
Lang EJ
2001 Mar 1;21(5):1663-1675, Journal of neuroscience
— id: 26780, year: 2001, vol: 21, page: 1663, stat: Journal Article,

Spontaneous activity of the perirhinal cortex in behaving cats
Collins DR; Lang EJ; Pare D
1999 ;89(4):1025-1039, Neuroscience
— id: 7315, year: 1999, vol: 89, page: 1025, stat: Journal Article,

Patterns of spontaneous purkinje cell complex spike activity in the awake rat
Lang EJ; Sugihara I; Welsh JP; Llinas R
1999 Apr 1;19(7):2728-2739, Journal of neuroscience
— id: 6067, year: 1999, vol: 19, page: 2728, stat: Journal Article,

Synaptic responsiveness of interneurons of the cat lateral amygdaloid nucleus
Lang EJ; Pare D
1998 Apr;83(3):877-889, Neuroscience
— id: 7644, year: 1998, vol: 83, page: 877, stat: Journal Article,

Patterns of spontaneous complex spike activity in the non-anesthetized rodent
Lang, E. J.; Sugihara, I.; Llinas, R.
1998 ;24(1-2):665-665, Abstracts (Society for Neuroscience)
— id: 92325, year: 1998, vol: 24, page: 665, stat: Journal Article,

Calcium electrogenesis in neocortical pyramidal neurons in vivo
Pare D; Lang EJ
1998 Oct;10(10):3164-3170, European journal of neuroscience
— id: 7732, year: 1998, vol: 10, page: 3164, stat: Journal Article,

Inhibitory control of somatodendritic interactions underlying action potentials in neocortical pyramidal neurons in vivo: an intracellular and computational study
Pare D; Lang EJ; Destexhe A
1998 May;84(2):377-402, Neuroscience
— id: 27413, year: 1998, vol: 84, page: 377, stat: Journal Article,

Impact of spontaneous synaptic activity on the resting properties of cat neocortical pyramidal neurons In vivo
Pare D; Shink E; Gaudreau H; Destexhe A; Lang EJ
1998 Mar;79(3):1450-1460, Journal of neurophysiology
— id: 7731, year: 1998, vol: 79, page: 1450, stat: Journal Article,

Similar inhibitory processes dominate the responses of cat lateral amygdaloid projection neurons to their various afferents
Lang EJ; Pare D
1997 Jan;77(1):341-352, Journal of neurophysiology
— id: 27412, year: 1997, vol: 77, page: 341, stat: Journal Article,

Synaptic and synaptically activated intrinsic conductances underlie inhibitory potentials in cat lateral amygdaloid projection neurons in vivo
Lang EJ; Pare D
1997 Jan;77(1):353-363, Journal of neurophysiology
— id: 27411, year: 1997, vol: 77, page: 353, stat: Journal Article,

Differential roles of apamin- and charybdotoxin-sensitive K+ conductances in the generation of inferior olive rhythmicity in vivo
Lang EJ; Sugihara I; Llinas R
1997 Apr 15;17(8):2825-2838, Journal of neuroscience
— id: 9883, year: 1997, vol: 17, page: 2825, stat: Journal Article,

The cerebellum, LTD, and memory: alternative views
Llinas R; Lang EJ; Welsh JP
1997 Mar-Apr;3(6):445-455, Learning & memory
— id: 7202, year: 1997, vol: 3, page: 445, stat: Journal Article,

A New Approach to the Analysis of Multidimensional Neuronal Activity: Markov Random Fields
Llinas R; Lang EJ; Welsh JP; Makarenko VI
1997 Jul;10(5):785-789, Neural networks
— id: 42309, year: 1997, vol: 10, page: 785, stat: Journal Article,

Differential impact of miniature synaptic potentials on the soma and dendrites of pyramidal neurons in vivo
Pare D; Lebel E; Lang EJ
1997 Sep;78(3):1735-1739, Journal of neurophysiology
— id: 27410, year: 1997, vol: 78, page: 1735, stat: Journal Article,

Morphological correlates of bilateral synchrony in the rat cerebellar cortex
De Zeeuw CI; Lang EJ; Sugihara I; Ruigrok TJ; Eisenman LM; Mugnaini E; Llinas R
1996 May 15;16(10):3412-3426, Journal of neuroscience
— id: 6990, year: 1996, vol: 16, page: 3412, stat: Journal Article,

GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in rat
Lang EJ; Sugihara I; Llinas R
1996 Jul;76(1):255-275, Journal of neurophysiology
— id: 7012, year: 1996, vol: 76, page: 255, stat: Journal Article,

Differential modulation of olivary rhythmicity by the K-channel blockers apamin, charybdotoxin and TEA
Lang, E. J.; Sugihara, I.; Llinas, R.
1995 ;21(1-3):271-271, Abstracts (Society for Neuroscience)
— id: 92346, year: 1995, vol: 21, page: 271, stat: Journal Article,

Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum
Sugihara I; Lang EJ; Llinas R
1995 Apr 1;7(4):521-534, European journal of neuroscience
— id: 6758, year: 1995, vol: 7, page: 521, stat: Journal Article,

Dynamic organization of motor control within the olivocerebellar system [see comments]
Welsh JP; Lang EJ; Suglhara I; Llinas R
1995 Mar 30;374(6521):453-457, Nature
— id: 6776, year: 1995, vol: 374, page: 453, stat: Journal Article,

The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study
Llinas R; Sugimori M; Lang EJ; Morita M; Fukuda M; Niinobe M; Mikoshiba K
1994 Dec 20;91(26):12990-12993, Proceedings of the National Academy of Sciences of the United States of America
— id: 6685, year: 1994, vol: 91, page: 12990, stat: Journal Article,

Time-resolved imaging of Ca(2+)-dependent aequorin luminescence of microdomains and QEDs in synaptic preterminals
Silver RB; Sugimori M; Lang EJ; Llinas R
1994 Dec;187(3):293-299, Biological bulletin
— id: 9895, year: 1994, vol: 187, page: 293, stat: Journal Article,

High-resolution measurement of the time course of calcium-concentration microdomains at squid presynaptic terminals
Sugimori M; Lang EJ; Silver RB; Llinas R
1994 Dec;187(3):300-303, Biological bulletin
— id: 6759, year: 1994, vol: 187, page: 300, stat: Journal Article,

Spatio-temporal structure in array recording of the behaving rat inferior olive
Sivaramakrishnan, A.; Welsh, J. P.; Lang, E. J.; Llinas, R.
1993 ;19(1-3):1279-1279, Abstracts (Society for Neuroscience)
— id: 92353, year: 1993, vol: 19, page: 1279, stat: Journal Article,

Uniform olivocerebellar conduction time underlies Purkinje cell complex spike synchronicity in the rat cerebellum
Sugihara I; Lang EJ; Llinas R
1993 Oct;470:243-271, Journal of physiology
— id: 6531, year: 1993, vol: 470, page: 243, stat: Journal Article,

The microstructure of coherence in the olivocerebellar system during rhythmic movement in normal and deafferented rats
Welsh, J. P.; Lang, E. J.; Llinas, R.
1993 ;19(1-3):1279-1279, Abstracts (Society for Neuroscience)
— id: 92354, year: 1993, vol: 19, page: 1279, stat: Journal Article,

The ability of motor cortex stimulation to evoke vibrissal movements is modulated by a 10 Hz signal arising in the inferior olive
Lang, E. J.; Sugihara, I.; Llinas, R.
1992 ;18(1-2):407-407, Abstracts (Society for Neuroscience)
— id: 92374, year: 1992, vol: 18, page: 407, stat: Journal Article,

A new treatment of spatio-temporal structure in array recording of the rat inferior olive
Sivaramakrishnan, A.; Lang, E. J.; Sugihara, I.; Sivaramakrishnan, S.; Llinas, R.
1992 ;18(1-2):1206-1206, Abstracts (Society for Neuroscience)
— id: 92362, year: 1992, vol: 18, page: 1206, stat: Journal Article,

Differing climbing fiber length implies variable conduction velocity to establish isochronicity of climbing fiber conduction times
Sugihara, I.; Lang, E. J.; De Zeeuw, C. I.; Llinas, R.
1992 ;18(1-2):1206-1206, Abstracts (Society for Neuroscience)
— id: 92363, year: 1992, vol: 18, page: 1206, stat: Journal Article,

Rhythmic olivo-cerebellar control of skilled tongue movement in relation to patterned hypoglossal nerve activity
Welsh, J. P.; Lang, E. J.; Sugihara, I.; Llinas, R.
1992 ;18(1-2):407-407, Abstracts (Society for Neuroscience)
— id: 92373, year: 1992, vol: 18, page: 407, stat: Journal Article,

MULTIELECTRODE RECORDINGS OF COMPLEX SPIKE ACTIVITY AND THEIR RELATIONSHIP TO SPONTANEOUS AND CORTICALLY EVOKED VIBRISSAL MOVEMENTS IN THE RAT
LANG E J; SUGIHARA I; WELSH J P; LLINAS R
1991 ;17(1-2):920-920, Abstracts (Society for Neuroscience)
— id: 92380, year: 1991, vol: 17, page: 920, stat: Journal Article,

ALTERATION OF COMPLEX SPIKE SYNCHRONICITY BY MICROINJECTION OF TEA AND 5-HT INTO THE INFERIOR OLIVE STUDIED WITH MULTIPLE ELECTRODE RECORDINGS
SUGIHARA I; LANG E J; LLINAS R
1991 ;17(1-2):919-919, Abstracts (Society for Neuroscience)
— id: 92381, year: 1991, vol: 17, page: 919, stat: Journal Article,

MULTIELECTRODE RECORDING OF PURKINJE CELL COMPLEX SPIKES DURING CONDITIONED TONGUE PROTRUSION IN THE AWAKE RAT
WELSH J P; SUGIHARA I; LANG E J; LLINAS R
1991 ;17(1-2):920-920, Abstracts (Society for Neuroscience)
— id: 92379, year: 1991, vol: 17, page: 920, stat: Journal Article,

INTRAOLIVARY INJECTION OF PICROTOXIN CAUSES REORGANIZATION OF COMPLEX SPIKE ACTIVITY
LANG E J; CHOU M; SUGIHARA I; LLINAS R
1989 ;15(1):179-179, Abstracts (Society for Neuroscience)
— id: 92413, year: 1989, vol: 15, page: 179, stat: Journal Article,

Mnemonic correlates of unit activity in the hippocampus
Wible CG; Findling RL; Shapiro M; Lang EJ; Crane S; Olton DS
1986 Dec 3;399(1):97-110, Brain research
— id: 27414, year: 1986, vol: 399, page: 97, stat: Journal Article,