Daniel L Labovitz, M.D.

CLINICAL FEATURES AND TREATMENT OF IN-HOSPITAL SEIZURES AT AN ACADEMIC MEDICAL CENTER
Fields, M; French, J; Labovitz, DL; Radwani, RR; Joshi, AV
2009 NOV ;50(1):264-265, Epilepsia
— id: 106073, year: 2009, vol: 50, page: 264, stat: Journal Article,

Sociodemographic Predictors of Early Arrival after Stroke in New York City: Age, Race and Birthplace
Labovitz, DL; Schweiger, L
2009 APR ;40(4):E182-E182, Stroke
— id: 97793, year: 2009, vol: 40, page: E182, stat: Journal Article,

Spontaneous intracerebral haemorrhage
Salman, RAS; Labovitz, DL; Stapf, C
2009 JUL 24 ;339(5):S31-S31, British medical journal. BMJ (International ed.)
— id: 101313, year: 2009, vol: 339, page: S31, stat: Journal Article,

Accuracy and yield of ICD-9 codes for identifying children with ischemic stroke
Labovitz, Daniel L
2007 May 8;68(19):1638-1638, Neurology
— id: 95780, year: 2007, vol: 68, page: 1638, stat: Journal Article,

Lacunar infarct or deep intracerebral hemorrhage: who gets which? The Northern Manhattan Study
Labovitz, Daniel L; Boden-Albala, Bernadette; Hauser, W Allen; Sacco, Ralph L
2007 Feb 20;68(8):606-608, Neurology
Lacunar infarcts (LACs) and deep intracerebral hemorrhages (DICHs) occur in the same structures and may result from the same pathology. It is unclear why one patient has an LAC while another has DICH. We compared LAC to DICH cases derived from a population-based incidence study. In multivariate analysis, LAC cases were significantly older, more likely to have diabetes, and had higher cholesterol than DICH cases
— id: 71236, year: 2007, vol: 68, page: 606, stat: Journal Article,

Auras are frequent in idiopathic generalized epilepsy
Boylan, L S; Labovitz, D L; Jackson, S C; Starner, K; Devinsky, O
2006 Jul 25;67(2):343-345, Neurology
The occurrence of an aura is often considered evidence of a partial rather than an idiopathic generalized epilepsy syndrome. The authors examined this hypothesis by prospectively recording reports of auras by patients being admitted for video-EEG monitoring. Auras were equally common (70%) among patients with idiopathic generalized epilepsy as they were among those with localization-related epilepsy. Presence of an aura is not a reliable indicator of localization-related epilepsy
— id: 67391, year: 2006, vol: 67, page: 343, stat: Journal Article,

Subarachnoid hemorrhage incidence among Whites, Blacks and Caribbean Hispanics: the Northern Manhattan Study
Labovitz, D L; Halim, A X; Brent, B; Boden-Albala, B; Hauser, W A; Sacco, R L
2006 ;26(3):147-150, Neuroepidemiology
American blacks and Hispanics may have a greater incidence of subarachnoid hemorrhage (SAH) than whites, but incidence data are scant. We used an active hospital and community surveillance program and autopsy reports to identify incident SAH cases among white, black and Hispanic adults living in Northern Manhattan between July 1993 and June 1997. The annual incidence adjusted for age and sex to the 1990 US Census was 9.7 per 100,000 (95% CI 7.5-12.0). Compared with whites (9 cases, age- and sex-adjusted annual incidence 8.2 per 100,000), the rate ratio of SAH was 1.3 (95% CI 0.7-2.4) for Hispanics (34 cases, incidence 10.9), and 1.6 (95% CI 0.8-2.8) for blacks (9 cases, incidence 12.8). The 30-day case fatality rate was 26%. Risk of death increased significantly with age and severity at onset but was not influenced by gender or race-ethnicity
— id: 64647, year: 2006, vol: 26, page: 147, stat: Journal Article,

Predictors of hospital arrival within 3 hours of stroke onset
Labovitz, DL; Benjamin, K; Bhatti, MI; Nasrallah, EJ; Benson, RT
2006 FEB ;37(2):705-705, Stroke
— id: 69268, year: 2006, vol: 37, page: 705, stat: Journal Article,

Determinants of hospitalization with TIA versus ischemic stroke among whites, blacks and Hispanics
Labovitz, DL; Benjamin, K; Nasrallah, EJ; Benson, RT
2006 MAR 14 ;66(5):A23-A23, Neurology
— id: 69267, year: 2006, vol: 66, page: A23, stat: Journal Article,

The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and Hispanics - Reply
Labovitz, DL; Halim, A; Boden-Albala, B; Hauser, WA; Sacco, RL
2006 MAR 28 ;66(6):957-957, Neurology
— id: 69274, year: 2006, vol: 66, page: 957, stat: Journal Article,

The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and Hispanics
Labovitz, D L; Halim, A; Boden-Albala, B; Hauser, W A; Sacco, R L
2005 Aug 23;65(4):518-522, Neurology
BACKGROUND: Black and Hispanic Americans have a greater risk of primary intracerebral hemorrhage (ICH) than whites. Deep ICH is most often associated with hypertension, while lobar ICH is associated with cerebral amyloid angiopathy. The authors conducted a population-based incidence study to directly compare the incidence of deep vs lobar ICH in all three race-ethnic groups. METHODS: The authors used an active hospital and community surveillance program and autopsy reports to identify incident ICH cases among white, black, and Caribbean Hispanic adults in Northern Manhattan between July 1993 and June 1997. Incidence rates were adjusted for age and sex to the 1990 US Census. CIs for risk ratios (RR) were calculated with Byar's chi2 approximation of the Poisson distribution. RESULTS: The authors identified 155 cases of ICH for an annual incidence of 30.9/100,000 (26.7 to 35.0). Men had a higher risk of ICH than women (RR 1.5, 95% CI 1.2 to 1.8), driven entirely by the incidence of deep ICH (RR 1.8) rather than lobar ICH (RR 1.0). Compared with whites, RR for blacks was all ICH 3.8 (2.2 to 8.9), deep 4.8 (2.3 to 21.1), lobar 2.8 (1.2 to 14.4); RR for Hispanics was all 2.6 (1.4 to 6.1), deep 3.7 (1.7 to 16.5), lobar 1.4 (0.4 to 7.4). CONCLUSIONS: ICH is a heterogeneous disease with deep and lobar subtypes distinguishable on an epidemiologic basis. The different patterns of these two subtypes in our race-ethnically diverse population lend credence to the notion that ICH should no longer be treated as a single entity
— id: 69263, year: 2005, vol: 65, page: 518, stat: Journal Article,

Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy
Boylan, L S; Flint, L A; Labovitz, D L; Jackson, S C; Starner, K; Devinsky, O
2004 Jan 27;62(2):258-261, Neurology
BACKGROUND: The two-thirds of patients with epilepsy who become seizure-free have a quality of life (QOL) similar to the general population. The major treatment challenge is patients with refractory epilepsy. Whereas neurologists typically focus on seizure reduction in the treatment of these patients, results of studies relating seizure frequency to QOL are conflicting. As depression is associated with reduced QOL in epilepsy and antiepileptic medications (AEDs) can cause depression, it is important to determine the relative roles of depression and seizure frequency in QOL in refractory epilepsy. METHODS: Prospective evaluation was conducted of patients with refractory epilepsy being admitted to an inpatient video-EEG monitoring unit. The impact of clinical variables (age, sex, marital status, seizure frequency, duration and type of seizure disorder, seizure localization, number of AEDs, depression) on QOL was analyzed. RESULTS: Depression was a powerful predictor of QOL (n = 122, beta = -35.8, p < 0.0001). No other variable predicted QOL. Depression was common (54%), severe (19% with suicidal thoughts), underdiagnosed (37%), and largely untreated (17% on antidepressants). CONCLUSIONS: Treatment of depression may be inadequately prioritized in the management of intractable epilepsy
— id: 47901, year: 2004, vol: 62, page: 258, stat: Journal Article,

Unbalanced statistical analysis of combined divalproex and antipsychotic therapy for schizophrenia
Boylan, Laura S; Labovitz, Daniel L
2004 Mar;29(3):636-636, Neuropsychopharmacology
— id: 69211, year: 2004, vol: 29, page: 636, stat: Journal Article,

Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy - Reply from the authors
Boylan, LS; Labovitz, DL; Flint, LA; Devinsky, O
2004 SEP 14 ;63(5):942-943, Neurology
— id: 69277, year: 2004, vol: 63, page: 942, stat: Journal Article,

The effect of smoking and arterial hypertension on intracranial hemorrhage in patients with brain arteriovenous malformation
Labovitz, DL; Convery, AB; Khaw, AV; Sciacca, RR; Mast, H; Mohr, JP; Stapf, C
2004 JAN ;35(1):329-329, Stroke
— id: 69270, year: 2004, vol: 35, page: 329, stat: Journal Article,

Risk determinants for seizures at initial presentation in patients with brain arteriovenous malformations
Labovitz, DL; Mohr, JP; Sciacca, RR; Mast, JI; Stapl, C
2004 JUN ;35(6):E291-E291, Stroke
— id: 69269, year: 2004, vol: 35, page: E291, stat: Journal Article,

Risk determinants for seizures in patients presenting with brain arteriovenous malformation
Stapf C; Labovitz DL; Sciacca RR; Mast H; Mohr JP
2004 ;62(Suppl 5):A178-A178 #S19.003, Neurology
— id: 69279, year: 2004, vol: 62, page: A178, stat: Journal Article,

Preventing stroke-related seizures: when should anticonvulsant drugs be started?
Labovitz, Daniel L; Hauser, W Allen
2003 Feb 11;60(3):365-366, Neurology
— id: 69212, year: 2003, vol: 60, page: 365, stat: Journal Article,

Utility of portable electroencephalography in an urban intensive care unit
Peterson DJ; Labovitz DL; Shapiro JM
2003 ;167:A969-A969, American journal of respiratory & critical care medicine
— id: 69278, year: 2003, vol: 167, page: A969, stat: Journal Article,

Intracranial hemorrhage: Stable proportion of underlying brain arteriovenous malformations across independent population samples
Stapf, C; Labovitz, DL; Schumacher, HC; Khaw, AV; Mast, H; Sacco, RL; Mohr, JP
2003 JAN ;34(1):276-276, Stroke
— id: 69271, year: 2003, vol: 34, page: 276, stat: Journal Article,

Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey
Stapf, Christian; Labovitz, Daniel L; Sciacca, Robert R; Mast, Henning; Mohr, Jay P; Sacco, Ralph L
2002 ;13(1):43-46, Cerebrovascular diseases
BACKGROUND: Brain arteriovenous malformations (AVMs) represent a potential source of intracranial hemorrhage, especially in young adults, but prospective population-based incidence data on AVM hemorrhage are lacking. We investigated the incidence of first-ever AVM hemorrhage in adults based on population data from the Northern Manhattan Stroke Study (NOMASS). METHODS: NOMASS is a prospective, population-based, stroke incidence survey collecting all hospitalized and nonhospitalized cases with first-ever (incident) stroke over the age of 20 in a ZIP code-defined area. All patients undergo CT and/or MR brain imaging and clinical data are systematically collected from the medical records. For this study, data on all cases with incident intracranial hemorrhage, i.e. any intracerebral, intraventricular and/or subarachnoid hemorrhage, occurring between July 1, 1993 and June 30, 1997 were used. Patients with intracranial hemorrhage due to trauma, tumor or intracranial vascular malformations other than a previously unknown AVM were excluded from the study. RESULTS: Of the 207 patients diagnosed with a first-ever intracranial hemorrhage, 3 cases (1.4%) with an underlying brain AVM were identified. The crude incidence rate for first-ever AVM hemorrhage in our adult population was 0.55 per 100,000 person-years (95% confidence interval 0.11-1.61). CONCLUSIONS: Our results support prior findings from retrospective surveys. Population-based studies providing a prospective design for AVM detection and diagnosis are needed to confirm the data
— id: 69213, year: 2002, vol: 13, page: 43, stat: Journal Article,

Prevalence and predictors of early seizure and status epilepticus after first stroke
Labovitz, D L; Hauser, W A; Sacco, R L
2001 Jul 24;57(2):200-206, Neurology
BACKGROUND: Early seizure (ES) has been reported in 2% to 6% of strokes and is a predictor of recurrent seizures. Acute stroke has been reported to cause 22% of all cases of status epilepticus in adults. The determinants of ES and status epilepticus (SE) after stroke, however, are not well understood. METHODS: An incidence study was conducted to identify all cases of first stroke in adult residents of northern Manhattan. Cases of ES and SE within 7 days of stroke were identified through medical record review. Statistical analyses were performed using univariate and multivariate logistic regression models. RESULTS: The cohort consisted of 904 patients; ES occurred in 37 (4.1%). The frequency of ES by stroke subtype and location was deep infarct 0.6% (2/356), lobar infarct 5.9% (20/341), deep intracerebral hemorrhage (ICH) 4.0% (4/101), lobar ICH 14.3% (7/49), and subarachnoid hemorrhage 8.0% (4/50). SE occurred in 10 patients (1.1%), representing 27.0% of patients with ES. Diabetes, hypertension, current smoking, alcohol use, age, gender, and race/ethnicity were not significant determinants of ES. In a subgroup of patients who had an NIH stroke scale (NIHSS) score recorded, NIHSS score was not an independent predictor of ES in multivariate analysis. After accounting for stroke severity, ES was not a predictor of 30-day case fatality. CONCLUSIONS: Lesion location and stroke subtype are strong determinants of ES risk, even after adjusting for stroke severity. ES does not predict 30-day mortality. SE occurs in more than one-quarter of patients with ES
— id: 69264, year: 2001, vol: 57, page: 200, stat: Journal Article,

Intracerebral hemorrhage: update
Labovitz, D L; Sacco, R L
2001 Feb;14(1):103-108, Current opinion in neurology
The present review focuses on evolving concepts in the pathogenesis and management of deep and lobar intracerebral hemorrhage subtypes, with particular focus on the relationship between lobar intracerebral hemorrhage, apolipoprotein E subtypes and cerebral amyloid angiopathy; deep intracerebral hemorrhage and the potential interaction between hypertension and low cholesterol; and new concepts in medical and surgical therapy for acute intracerebral hemorrhage
— id: 69265, year: 2001, vol: 14, page: 103, stat: Journal Article,

Cognitive function measures added to the NIH stroke scale improves correlation with acute stroke volume
Wright, CB; Scarmeas, N; Perera, GM; Lazar, RM; Fitzsimmons, BFM; Labovitz, D; Stapf, C; Benson, R; Robinson, JV; Marshall, RS
2001 APR 24 ;56(8):A436-A437, Neurology
— id: 69272, year: 2001, vol: 56, page: A436, stat: Journal Article,

The incidence and 30-day case-fatality rate of subarachnoid hemorrhage in a multiethnic population: The Northern Manhattan Stroke Study
Halim, A; Labovitz, DL; Sacco, RL
2000 APR 11 ;54(7):A461-A462, Neurology
— id: 69276, year: 2000, vol: 54, page: A461, stat: Journal Article,

30-day case fatality in a multi-ethnic, population-based incident stroke cohort in Northern Manhattan
Labovitz, D; Rundek, T; Benson, R; Sacco, R
2000 NOV ;31(11):2793-2793, Stroke
— id: 69273, year: 2000, vol: 31, page: 2793, stat: Journal Article,

Incidence of intracerebral hemorrhage and predictors of deep versus lobar location in a multi-ethnic population: The Northern Manhattan Stroke Study
Labovitz, DL; Halim, A; Lennihan, L; Mayer, SA; Boden-Albala, B; Sacco, RL
2000 APR 11 ;54(7):A298-A298, Neurology
— id: 69275, year: 2000, vol: 54, page: A298, stat: Journal Article,

Schizophrenia after prenatal famine. Further evidence
Susser, E; Neugebauer, R; Hoek, H W; Brown, A S; Lin, S; Labovitz, D; Gorman, J M
1996 Jan;53(1):25-31, Archives of general psychiatry
BACKGROUND: Suggestive findings of an earlier study that prenatal nutritional deficiency was a determinant of schizophrenia prompted us to undertake a second test of the hypothesis using more precise data on both exposure and outcome. METHODS: Among persons born in the cities of western Netherlands during 1944 through 1946, we compared the risk for schizophrenia in those exposed and unexposed during early gestation to the Dutch Hunger Winter of 1944/1945. The frequency of hospitalized patients with schizophrenia at age 24 to 48 years in the exposed and unexposed birth cohorts was ascertained from a national psychiatric registry. RESULTS: The most exposed birth cohort, conceived at the height of the famine, showed a twofold and statistically significant increase in the risk for schizophrenia (relative risk [RR] = 2.0; 95% confidence interval [CI] = 1.2 to 3.4; P < .01) in both men (RR = 1.9; 95% CI = 1.0 to 3.7; P = .05) and women (RR = 2.2; 95% CI = 1.0 to 4.7; P = .04). Among all birth cohorts of 1944 through 1946, the risk for schizophrenia clearly peaked in this exposed cohort. CONCLUSION: Prenatal nutritional deficiency may play a role in the origin of some cases of schizophrenia
— id: 69266, year: 1996, vol: 53, page: 25, stat: Journal Article,