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Suman Laal

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Suman Laal, Ph.D.

Associate Professor;
Departments of Pathology (Pathology) and Microbiology (Microbiology )

Contact Info

Address
423 East 23 Street
VA New York Harbor Healthcare System Floor 18 Room 18147N
Veterans Administration
New York, NY 10010

Fax: 212-951-6321
Email: Suman.Laal@nyumc.org

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Research Summary

M. tuberculosis is a versatile organism, capable of adapting to a variety of different environments. We have provided evidence that M. tuberculosis alters the profile of antigenic proteins expressed in vivo during different stages of disease progression. Understanding of the host-pathogen interactions and the immune events that occur during the early stages post-infection is required for obtaining insight into the pathogenesis of M. tuberculosis infection, and for design of rational intervention strategies for TB. The current interests of our laboratory are two fold. First, to understand the M. tuberculosis-host interaction that occurs during the early stages post-infection, we have conducted studies with animal models of TB, and identified several novel proteins of M. tuberculosis that are expressed in vivo by the inhaled bacteria during the first few weeks post-infection. Many of these proteins have characteristics of surface or secreted proteins, and have structural similarities to proteins involved in binding/adhesion/invasion in other bacteria. Studies aimed at defining the role of these proteins in interaction with the host cells, and in eliciting cellular and humoral immune responses are ongoing. These studies will provide insight into the host-pathogen interaction that occurs upon infection. In addition, these proteins could be candidates for devising vaccines, and/or surrogate markers for identifying individuals with active, pre-clinical infection with M. tuberculosis.

Second, based on a systematic analysis of the humoral immune responses of TB patients at different stages of disease progression, we have identified a set of immuno-dominant culture filtrate proteins of M. tuberculosis that are candidates for devising a rapid, point-of-care diagnostic test for TB. Some of these candidate proteins have been cloned and are currently being dissected to identify the immuno-dominant epitopes associated with active disease. We have also provided evidence that anti-mycobacterial antibodies are present in the urine of TB patients. In view of the lack of resources and infrastructure in developing countries, the high prevalence of active and latent TB in these countries, the increasing incidence of HIV-infection, and the high rates of reactivation TB in the co-infected patients, these studies raise the exciting possibility of developing an inexpensive, safe, urine-based immuno-diagnostic test for TB. Efforts to devise such a test are also ongoing.

Research Interests

Pathogenesis of M.tuberculosis Infection in Humans<br>

Research Keywords

diagnosis, M. tuberculosis, pathogenesis<br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Analysis of humoral responses to proteins encoded by region of difference 1 of Mycobacterium tuberculosis in sarcoidosis in a high tuberculosis prevalence country
Agarwal, Ritesh; Gupta, Dheeraj; Srinivas, Rajagopala; Verma, Indu; Aggarwal, Ashutosh N; Laal, Suman
2012 Jun;135(6):920-923, Indian journal of medical research
— id: 178319, year: 2012, vol: 135, page: 920, stat: Journal Article,

How Does Mycobacterium tuberculosis Establish Infection?
Laal, Suman
2012 Oct;206(8):1157-1159, Journal of infectious diseases
— id: 178832, year: 2012, vol: 206, page: 1157, stat: Journal Article,

LipC (Rv0220) Is an Immunogenic Cell Surface Esterase of Mycobacterium tuberculosis
Shen, Guomiao; Singh, Krishna; Chandra, Dinesh; Serveau-Avesque, Carole; Maurin, Damien; Canaan, Stephane; Singla, Rupak; Behera, Digambar; Laal, Suman
2012 JAN ;80(1):243-253, Infection & immunity
— id: 150799, year: 2012, vol: 80, page: 243, stat: Journal Article,

Systematic review and meta-analysis of antigen detection tests for the diagnosis of tuberculosis
Flores L.L.; Steingart K.R.; Dendukuri N.; Schiller I.; Minion J.; Pai M.; Ramsay A.; Henry M.; Laal S.
2011 ;18(10):1616-1627, Clinical & vaccine immunology
— id: 138727, year: 2011, vol: 18, page: 1616, stat: Journal Article,

Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis
Steingart, Karen R; Flores, Laura L; Dendukuri, Nandini; Schiller, Ian; Laal, Suman; Ramsay, Andrew; Hopewell, Philip C; Pai, Madhukar
2011 Aug;8(8):e1001062-e1001062, PLoS medicine
— id: 137459, year: 2011, vol: 8, page: e1001062, stat: Journal Article,

Antibodies against immunodominant antigens of Mycobacterium tuberculosis in subjects with suspected tuberculosis in the United States compared by HIV status
Achkar, Jacqueline M; Jenny-Avital, Elisabeth; Yu, Xian; Burger, Susanne; Leibert, Eric; Bilder, Patrick W; Almo, Steven C; Casadevall, Arturo; Laal, Suman
2010 Mar;17(3):384-392, Clinical & vaccine immunology
— id: 133488, year: 2010, vol: 17, page: 384, stat: Journal Article,

Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells
Kinhikar, Arvind G; Verma, Indu; Chandra, Dinesh; Singh, Krishna K; Weldingh, Karin; Andersen, Peter; Hsu, Tsungda; Jacobs, William R Jr; Laal, Suman
2010 Jan;75(1):92-106, Molecular microbiology
— id: 106091, year: 2010, vol: 75, page: 92, stat: Journal Article,

Neutralization efficiency and presence of anti-V3 antibodies in plasma of HIV-1 infected Northern Indians
Choudhary, Alok K.; Dutta, Subhashree; Wig, Naveet; Biswas, A.; Andrabi, Raiees; Kalra, Rajesh; Bhasin, Rama; Pazner, Susan Zolla; Laal, Suman; Luthra, Kalpana
2009 JUN ;51(10):160-160, Journal of acquired immune deficiency syndromes. JAIDS
— id: 113759, year: 2009, vol: 51, page: 160, stat: Journal Article,

Identification of Mycobacterium avium KatG protein (MAV_2753) as a possible serodiagnostic marker for MAC disease
Gupta, Kapil; Khuller, Gopal Krishan; Wanchu, Ajay; Laal, Suman; Latawa, Romica; Verma, Indu
2009 Feb;58(2):170-172, Journal of infection
— id: 95778, year: 2009, vol: 58, page: 170, stat: Journal Article,

Mycobacterium avium KatG protein (MAV_2753): a putative candidate for the serodiagnosis of MAC disease
Gupta, Kapil; Wanchu, Ajay; Latawa, Romica; Laal, S.; Khuller, G. K.; Verma, Indu
2009 JUN ;51(10):168-168, Journal of acquired immune deficiency syndromes. JAIDS
— id: 113760, year: 2009, vol: 51, page: 168, stat: Journal Article,

Peptide-based antibody detection for tuberculosis diagnosis
Shen, Guomiao; Behera, Digambar; Bhalla, Manpreet; Nadas, Arthur; Laal, Suman
2009 Jan;16(1):49-54, Clinical & vaccine immunology
— id: 92172, year: 2009, vol: 16, page: 49, stat: Journal Article,

Peptides of a novel Mycobacterium tuberculosis-specific cell wall protein for immunodiagnosis of tuberculosis
Singh, Krishna K; Sharma, Naresh; Vargas, Diana; Liu, Zhentong; Belisle, John T; Potharaju, Visalakshi; Wanchu, Ajay; Behera, Digambar; Laal, Suman
2009 Aug 15;200(4):571-581, Journal of infectious diseases
— id: 101637, year: 2009, vol: 200, page: 571, stat: Journal Article,

Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis
Steingart, Karen R; Dendukuri, Nandini; Henry, Megan; Schiller, Ian; Nahid, Payam; Hopewell, Philip C; Ramsay, Andrew; Pai, Madhukar; Laal, Suman
2009 Feb;16(2):260-276, Clinical & vaccine immunology
— id: 95779, year: 2009, vol: 16, page: 260, stat: Journal Article,

Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country
Wanchu, Ajay; Dong, Yuxin; Sethi, Sunil; Myneedu, V P; Nadas, Arthur; Liu, Zhentong; Belisle, John; Laal, Suman
2008 ;3(4):e2071-e2071, PLoS ONE
— id: 78837, year: 2008, vol: 3, page: e2071, stat: Journal Article,

A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
Steingart, Karen R; Henry, Megan; Laal, Suman; Hopewell, Philip C; Ramsay, Andrew; Menzies, Dick; Cunningham, Jane; Weldingh, Karin; Pai, Madhukar
2007 Nov;83(985):705-712, Postgraduate medical journal
— id: 78838, year: 2007, vol: 83, page: 705, stat: Journal Article,

A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
Steingart, Karen R; Henry, Megan; Laal, Suman; Hopewell, Philip C; Ramsay, Andrew; Menzies, Dick; Cunningham, Jane; Weldingh, Karin; Pai, Madhukar
2007 Oct;62(10):911-918, Thorax
— id: 78839, year: 2007, vol: 62, page: 911, stat: Journal Article,

Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review
Steingart, Karen R; Henry, Megan; Laal, Suman; Hopewell, Philip C; Ramsay, Andrew; Menzies, Dick; Cunningham, Jane; Weldingh, Karin; Pai, Madhukar
2007 Jun;4(6):e202-e202, PLoS medicine
— id: 78840, year: 2007, vol: 4, page: e202, stat: Journal Article,

Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis
Achkar, Jacqueline M; Dong, Yuxin; Holzman, Robert S; Belisle, John; Kourbeti, Irene S; Sherpa, Tsering; Condos, Rany; Rom, William N; Laal, Suman
2006 Nov;13(11):1291-1293, Clinical & vaccine immunology
— id: 70310, year: 2006, vol: 13, page: 1291, stat: Journal Article,

Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypes
Khurana, Surender; Needham, James; Park, Susan; Mathieson, Bonnie; Busch, Michael P; Nemo, George; Nyambi, Phillipe; Zolla-Pazner, Susan; Laal, Suman; Mulenga, Joseph; Chomba, Elwyn; Hunter, Eric; Allen, Susan; McIntyre, James; Hewlett, Indira; Lee, Sherwin; Tang, Shixing; Cowan, Elliot; Beyrer, Chris; Altfeld, Marcus; Yu, Xu G; Tounkara, Anatole; Koita, Ousmane; Kamali, Anatoli; Nguyen, Nga; Graham, Barney S; Todd, Deborah; Mugenyi, Peter; Anzala, Omu; Sanders, Eduard; Ketter, Nzeera; Fast, Patricia; Golding, Hana
2006 Nov 1;43(3):304-312, Journal of acquired immune deficiency syndromes. JAIDS
— id: 78810, year: 2006, vol: 43, page: 304, stat: Journal Article,

Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin
Kinhikar, Arvind G; Vargas, Diana; Li, Hualin; Mahaffey, Spencer B; Hinds, Laura; Belisle, John T; Laal, Suman
2006 May;60(4):999-1013, Molecular microbiology
— id: 67530, year: 2006, vol: 60, page: 999, stat: Journal Article,

Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling
Sartain, Mark J; Slayden, Richard A; Singh, Krishna K; Laal, Suman; Belisle, John T
2006 Nov;5(11):2102-2113, Molecular & cellular proteomics
— id: 78841, year: 2006, vol: 5, page: 2102, stat: Journal Article,

Immunodiagnosis
Laal, Suman
Tuberculosis Philadelphia : Lippincott Williams & Wilkins, 2004,
— id: 3964, year: 2004, vol: , page: 186, stat: Chapter,

The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10
Huard, Richard C; Chitale, Sadhana; Leung, Mary; Lazzarini, Luiz Claudio Oliveira; Zhu, Hongxia; Shashkina, Elena; Laal, Suman; Conde, Marcus B; Kritski, Afranio L; Belisle, John T; Kreiswirth, Barry N; Lapa e Silva, Jose Roberto; Ho, John L
2003 Dec;71(12):6871-6883, Infection & immunity
— id: 78842, year: 2003, vol: 71, page: 6871, stat: Journal Article,

Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan
Navoa, Josephine Anne D; Laal, Suman; Pirofski, Liise-Anne; McLean, Gary R; Dai, Zhongdong; Robbins, John B; Schneerson, Rachel; Casadevall, Arturo; Glatman-Freedman, Aharona
2003 Jan;10(1):88-94, Clinical & diagnostic laboratory immunology
— id: 78843, year: 2003, vol: 10, page: 88, stat: Journal Article,

Combined use of serum and urinary antibody for diagnosis of tuberculosis
Singh, Krishna K; Dong, Yuxin; Hinds, Laura; Keen, Marc A; Belisle, John T; Zolla-Pazner, Susan; Achkar, Jacqueline M; Nadas, Arthur J; Arora, Vijay K; Laal, Suman
2003 Aug 1;188(3):371-377, Journal of infectious diseases
— id: 39136, year: 2003, vol: 188, page: 371, stat: Journal Article,

Homogeneity of antibody responses in tuberculosis patients
Samanich K; Belisle JT; Laal S
2001 Jul;69(7):4600-4609, Infection & immunity
— id: 20613, year: 2001, vol: 69, page: 4600, stat: Journal Article,

Antigens of Mycobacterium tuberculosis Expressed during Preclinical Tuberculosis: Serological Immunodominance of Proteins with Repetitive Amino Acid Sequences
Singh KK; Zhang X; Patibandla AS; Chien P Jr; Laal S
2001 Jun;69(6):4185-4191, Infection & immunity
— id: 20669, year: 2001, vol: 69, page: 4185, stat: Journal Article,

HIV phenotype correlates with the relative amounts of lymphocyte function-related molecule 1 (LFA-1) and major histocompatibility complex (MHC) class II in the virion envelope [In Process Citation]
Bastiani Lallos L; Cecilia D; Fenyo EM; Laal S; Zolla-Pazner S
2000 Jul 28;14(11):1523-1531, AIDS
— id: 9226, year: 2000, vol: 14, page: 1523, stat: Journal Article,

Serodiagnostic potential of culture filtrate antigens of Mycobacterium tuberculosis
Samanich KM; Keen MA; Vissa VD; Harder JD; Spencer JS; Belisle JT; Zolla-Pazner S; Laal S
2000 Jul;7(4):662-668, Clinical & diagnostic laboratory immunology
— id: 11616, year: 2000, vol: 7, page: 662, stat: Journal Article,

Exclusion of HIV coreceptors CXCR4, CCR5, and CCR3 from the HIV envelope
Lallos LB; Laal S; Hoxie JA; Zolla-Pazner S; Bandres JC
1999 Jul 1;15(10):895-897, AIDS research & human retroviruses
— id: 6159, year: 1999, vol: 15, page: 895, stat: Journal Article,

Selective exclusion of HIV coreceptors from HIV virions
Bastiani L; Laal S; Hoxie JA; Zolla-Pazner S; Bandres JC
1998 Feb 1-5;5:85-85, Conference on Retroviruses & Opportunistic Infections
— id: 6008, year: 1998, vol: 5, page: 85, stat: Journal Article,

Delineation of human antibody responses to culture filtrate antigens of Mycobacterium tuberculosis
Samanich KM; Belisle JT; Sonnenberg MG; Keen MA; Zolla-Pazner S; Laal S
1998 Nov;178(5):1534-1538, Journal of infectious diseases
— id: 7777, year: 1998, vol: 178, page: 1534, stat: Journal Article,

Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions
Bastiani L; Laal S; Kim M; Zolla-Pazner S
1997 May;71(5):3444-3450, Journal of virology
— id: 9243, year: 1997, vol: 71, page: 3444, stat: Journal Article,

Host cell-dependent alterations in HIV envelope components
Bastiani L; Laal S; Zolla-Pazner S
1997 Jan 22-26;4:148-148, Conference on Retroviruses & Opportunistic Infections
— id: 6002, year: 1997, vol: 4, page: 148, stat: Journal Article,

Surrogate marker of preclinical tuberculosis in human immunodeficiency virus infection: antibodies to an 88-kDa secreted antigen of Mycobacterium tuberculosis
Laal S; Samanich KM; Sonnenberg MG; Belisle JT; O'Leary J; Simberkoff MS; Zolla-Pazner S
1997 Jul;176(1):133-143, Journal of infectious diseases
— id: 7953, year: 1997, vol: 176, page: 133, stat: Journal Article,

Human humoral responses to antigens of Mycobacterium tuberculosis: immunodominance of high-molecular-mass antigens
Laal S; Samanich KM; Sonnenberg MG; Zolla-Pazner S; Phadtare JM; Belisle JT
1997 Jan;4(1):49-56, Clinical & diagnostic laboratory immunology
— id: 9247, year: 1997, vol: 4, page: 49, stat: Journal Article,

Humoral responses in tuberculosis
Laal, Suman
Tuberculosis Boston : Little Brown, 1996,
— id: 4834, year: 1996, vol: , page: ?, stat: Chapter,

Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies
Laal S; Burda S; Gorny MK; Karwowska S; Buchbinder A; Zolla-Pazner S
1994 Jun;68(6):4001-4008, Journal of virology
— id: 9263, year: 1994, vol: 68, page: 4001, stat: Journal Article,

Human monoclonal antibodies to HIV-1 define synergistic activities leading to enhanced neutralization
Zolla-Pazner S; Laal S; Burda S; Buchbinder A
1994 ;46:38-47, Antibiotics & chemotherapy
— id: 9266, year: 1994, vol: 46, page: 38, stat: Journal Article,

Synergistic interaction of various pairs of human monoclonal antibodies in the neutralization of HIV-1
Laal S; Burda S; Buchbinder A; Zolla-Pazner S
1993 Dec 12-16;1:67-67, National Conference on Human Retroviruses & Related Infections
— id: 6012, year: 1993, vol: 1, page: 67, stat: Journal Article,

A rapid, automated microtiter assay for measuring neutralization of HIV-1
Laal S; Burda S; Sharpe S; Zolla-Pazner S
1993 Aug;9(8):781-785, AIDS research & human retroviruses
— id: 9271, year: 1993, vol: 9, page: 781, stat: Journal Article,

Antibodies to M. tuberculosis antigens in HIV-1 infected individuals
Laal S; Pazner SZ
1993 Dec 12-16;1:189-189, National Conference on Human Retroviruses & Related Infections
— id: 6013, year: 1993, vol: 1, page: 189, stat: Journal Article,

Epitopes of HIV-1 glycoproteins recognized by the human immune system
Laal S; Zolla-Pazner S
1993 ;56:91-111, Chemical immunology
— id: 9274, year: 1993, vol: 56, page: 91, stat: Journal Article,

Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T-cell responses across the leprosy spectrum
Laal S; Sharma YD; Prasad HK; Murtaza A; Singh S; Tangri S; Misra RS; Nath I
1991 Feb 1;88(3):1054-1058, Proceedings of the National Academy of Sciences of the United States of America
— id: 8355, year: 1991, vol: 88, page: 1054, stat: Journal Article,

Isolation and serological characterization of a Plasmodium vivax recombinant antigen
Sharma YD; Sharma VP; Ray P; Laal S; Sawant SD; Verma S
1991 Jun;59(6):1922-1926, Infection & immunity
— id: 15085, year: 1991, vol: 59, page: 1922, stat: Journal Article,

Nucleotide sequence and deduced amino acid sequence of Mycobacterium leprae gene showing homology to bacterial atp operon
Nath I; Laal S
1990 Aug 25;18(16):4935-4935, Nucleic acids research
— id: 15087, year: 1990, vol: 18, page: 4935, stat: Journal Article,

Human immune response to recombinant interferon gamma and protein antigen LSR2
Nath I; Laal S; Sivasai KS; Tangri S; Murtaza A; Singh S; Wilfred D; Misra RS
1990 Sep;41(3):324-325, Tropical medicine & parasitology
— id: 15086, year: 1990, vol: 41, page: 324, stat: Journal Article,

The nature and kinetics of a delayed immune response to purified protein derivative of tuberculin in the skin of lepromatous leprosy patients
Kaplan G; Laal S; Sheftel G; Nusrat A; Nath I; Mathur NK; Mishra RS; Cohn ZA
1988 Nov 1;168(5):1811-1824, Journal of experimental medicine
— id: 15088, year: 1988, vol: 168, page: 1811, stat: Journal Article,

Epidermal changes in reactional leprosy: keratinocyte Ia expression as an indicator of cell-mediated immune responses
Thangaraj H; Laal S; Thangaraj I; Nath I
1988 Sep;56(3):401-407, International journal of leprosy & other mycobacterial diseases
— id: 15089, year: 1988, vol: 56, page: 401, stat: Journal Article,