Lewis C Krey

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Lewis C Krey, Ph.D.

Clinical Professor; Dir And& EmbryLab NYU& Valley Fertility Ctr
Departments of Obstetrics and Gynecology (Obs/Gyn) and Cell Biology (Cell Biology)
NYU Fertility Center

Contact Info

Address
660 First Avenue
Floor 5
660 First Avenue
New York, NY 10016

212-263-6418, 212-263-8990
212-263-0059
Lewis.Krey@nyumc.org


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Education

1966-1971 — Dr. Krey received his Ph.D. degree in Physiology from Duke University, Durham, NC, Graduate Education
1971-1974 — Dr. Krey was a Postdoctoral Fellow in Physiology at the University of Pittsburgh School of Medicine, Pittsburgh, PA, PostDoctoral Training

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Research Summary

Reproductive capacity in mammals results from physiologic interplay between steroid hormones produced by the gonads and peptide hormones secreted by the anterior pituitary gland and brain. Clinical manipulation of these interactions can eventuate in fertility's induction or blockage. We examine cellular and molecular mechanisms underlying gonadal steroid regulation of the secretion of the gonadotropic hormone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) by the adenohypophysis and of gonadotropin-releasing hormone (GnRH) by the brain. This feedback regulation establishes the temporal and quantitative parameters of hypophysial gonadotropin secretion necessary for normal gonadal development and function.

Primarily, we monitor the direct actions of estrogens, progestins, and androgens by studying the physiology of rat gonadotrophs in cell culture. To date