Hannah L Klein

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Hannah L Klein, Ph.D.

Professor; Interim Chair & Professor
Departments of Biochemistry and Molecular Pharmacology, Medicine (Administration) and Pathology

Contact Info

550 First Avenue
Floor 3 Room 367
Medical Science Building
New York, NY 10016


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1971-1976 — University of Washington, Seattle, PhD in Genetics, Graduate Education
1976-1979 — Princeton University, Microbiology, PostDoctoral Training
1979-1981 — University of Chicago, Biochemistry, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -


How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells
Potenski, Catherine J; Klein, Hannah L
2014 Dec;42(16):10226-10234, Nucleic acids research
— id: 1209412, year: 2014, vol: 42, page: 10226, stat: Journal Article,

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms
Potenski, Catherine J; Niu, Hengyao; Sung, Patrick; Klein, Hannah L
2014 Jul;511(7508):251-254, Nature
— id: 1102852, year: 2014, vol: 511, page: 251, stat: Journal Article,

The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination
Burgess, Rebecca C; Sebesta, Marek; Sisakova, Alexandra; Marini, Victoria P; Lisby, Michael; Damborsky, Jiri; Klein, Hannah; Rothstein, Rodney; Krejci, Lumir
2013 ;8(12):e82630-e82630 e82630, PLoS one
— id: 741022, year: 2013, vol: 8, page: e82630, stat: Journal Article,

Tid1/Rdh54 translocase is phosphorylated through a Mec1- and Rad53-dependent manner in the presence of DSB lesions in budding yeast
Ferrari, Matteo; Nachimuthu, Benjamin Tamilselvan; Donnianni, Roberto Antonio; Klein, Hannah; Pellicioli, Achille
2013 May;12(5):347-355, DNA repair (Amsterdam)
— id: 348812, year: 2013, vol: 12, page: 347, stat: Journal Article,

Death becomes her: FBH1, DNA damage and apoptosis
Potenski, Catherine J; Klein, Hannah L
2013 May;12(9):1336-1336, Cell cycle
— id: 335592, year: 2013, vol: 12, page: 1336, stat: Journal Article,

Characterization of the Interaction between the Saccharomyces cerevisiae Rad51 Recombinase and the DNA Translocase Rdh54
Santa Maria, Sergio R; Kwon, Youngho; Sung, Patrick; Klein, Hannah L
2013 Jul;288(30):21999-22005, Journal of biological chemistry
— id: 463562, year: 2013, vol: 288, page: 21999, stat: Journal Article,

A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization
Islam, M Nurul; Paquet, Nicolas; Fox, David 3rd; Dray, Eloise; Zheng, Xiao-Feng; Klein, Hannah; Sung, Patrick; Wang, Weidong
2012 Jul;287(28):23808-23818, Journal of biological chemistry
— id: 174444, year: 2012, vol: 287, page: 23808, stat: Journal Article,

Sgs1-the maestro of recombination
Klein, Hannah L; Symington, Lorraine S
2012 Apr;149(2):257-259, Cell
— id: 164366, year: 2012, vol: 149, page: 257, stat: Journal Article,

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
Bermejo, Rodrigo; Capra, Thelma; Jossen, Rachel; Colosio, Arianna; Frattini, Camilla; Carotenuto, Walter; Cocito, Andrea; Doksani, Ylli; Klein, Hannah; Gomez-Gonzalez, Belen; Aguilera, Andres; Katou, Yuki; Shirahige, Katsuhiko; Foiani, Marco
2011 Jul 22;146(2):233-246, Cell
— id: 136488, year: 2011, vol: 146, page: 233, stat: Journal Article,

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors
Chi, Peter; Kwon, Youngho; Visnapuu, Mari-Liis; Lam, Isabel; Santa Maria, Sergio R; Zheng, Xiuzhong; Epshtein, Anastasiya; Greene, Eric C; Sung, Patrick; Klein, Hannah L
2011 Aug;39(15):6511-6522, Nucleic acids research
— id: 136937, year: 2011, vol: 39, page: 6511, stat: Journal Article,

The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
Hoot, Samantha J; Zheng, Xiuzhong; Potenski, Catherine J; White, Theodore C; Klein, Hannah L
2011 ;11:214-214, BMC microbiology
— id: 139736, year: 2011, vol: 11, page: 214, stat: Journal Article,

Molecular biology: The expanding arena of DNA repair
Potenski, Catherine J; Klein, Hannah L
2011 Mar 3;471(7336):48-49, Nature
— id: 134138, year: 2011, vol: 471, page: 48, stat: Journal Article,

R we there yet? R-loop hazards to finishing the journey
Potenski, Catherine J; Klein, Hannah L
2011 Dec;44(6):848-850, Molecular cell
— id: 155640, year: 2011, vol: 44, page: 848, stat: Journal Article,

Methods to study mitotic homologous recombination and genome stability
Zheng, Xiuzhong; Epstein, Anastasiya; Klein, Hannah L
2011 ;745:3-13, Methods in molecular biology
— id: 134456, year: 2011, vol: 745, page: 3, stat: Journal Article,

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair
Saponaro, Marco; Callahan, Devon; Zheng, Xiuzhong; Krejci, Lumir; Haber, James E; Klein, Hannah L; Liberi, Giordano
2010 Feb;6(2):e1000858-e1000858, PLoS genetics
— id: 107900, year: 2010, vol: 6, page: e1000858, stat: Journal Article,

Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth
Shah, Parisha P; Zheng, Xiuzhong; Epshtein, Anastasiya; Carey, Jeffrey N; Bishop, Douglas K; Klein, Hannah L
2010 Sep 24;39(6):862-872, Molecular cell
— id: 147665, year: 2010, vol: 39, page: 862, stat: Journal Article,

Functional interactions of meiotic recombination factors Rdh54 and Dmc1
Chi, Peter; Kwon, Youngho; Moses, Dana N; Seong, Changhyun; Sehorn, Michael G; Singh, Akhilesh K; Tsubouchi, Hideo; Greene, Eric C; Klein, Hannah L; Sung, Patrick
2009 Feb 1;8(2):279-284, DNA repair (Amsterdam)
— id: 107905, year: 2009, vol: 8, page: 279, stat: Journal Article,

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
Colavito, Sierra; Macris-Kiss, Margaret; Seong, Changhyun; Gleeson, Olive; Greene, Eric C; Klein, Hannah L; Krejci, Lumir; Sung, Patrick
2009 Nov;37(20):6754-6764, Nucleic acids research
— id: 107901, year: 2009, vol: 37, page: 6754, stat: Journal Article,

Breaking up just got easier to do
Klein, Hannah L; Symington, Lorraine S
2009 Jul 10;138(1):20-22, Cell
— id: 100674, year: 2009, vol: 138, page: 20, stat: Journal Article,

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
Prakash, Rohit; Satory, Dominik; Dray, Eloise; Papusha, Almas; Scheller, Jurgen; Kramer, Wilfried; Krejci, Lumir; Klein, Hannah; Haber, James E; Sung, Patrick; Ira, Grzegorz
2009 Jan 1;23(1):67-79, Genes & development
— id: 107904, year: 2009, vol: 23, page: 67, stat: Journal Article,

Structural transitions within human Rad51 nucleoprotein filaments
Robertson, Ragan B; Moses, Dana N; Kwon, YoungHo; Chan, Pamela; Chi, Peter; Klein, Hannah; Sung, Patrick; Greene, Eric C
2009 Aug 4;106(31):12688-12693, Proceedings of the National Academy of Sciences of the United States of America
— id: 107902, year: 2009, vol: 106, page: 12688, stat: Journal Article,

Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments
Robertson, Ragan B; Moses, Dana N; Kwon, YoungHo; Chan, Pamela; Zhao, Weixing; Chi, Peter; Klein, Hannah; Sung, Patrick; Greene, Eric C
2009 May 15;388(4):703-720, Journal of molecular biology
— id: 107903, year: 2009, vol: 388, page: 703, stat: Journal Article,

Molecular biology: DNA endgames
Klein, Hannah L
2008 Oct 9;455(7214):740-741, Nature
— id: 97749, year: 2008, vol: 455, page: 740, stat: Journal Article,

The consequences of Rad51 overexpression for normal and tumor cells
Klein, Hannah L
2008 May 3;7(5):686-693, DNA repair (Amsterdam)
— id: 80301, year: 2008, vol: 7, page: 686, stat: Journal Article,

ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54
Kwon, YoungHo; Seong, Changhyun; Chi, Peter; Greene, Eric C; Klein, Hannah; Sung, Patrick
2008 Apr 18;283(16):10445-10452, Journal of biological chemistry
— id: 107906, year: 2008, vol: 283, page: 10445, stat: Journal Article,

Mechanism of eukaryotic homologous recombination
San Filippo, Joseph; Sung, Patrick; Klein, Hannah
2008 ;77:229-257, Annual review of biochemistry
— id: 107907, year: 2008, vol: 77, page: 229, stat: Journal Article,

Reversal of fortune: Rad5 to the rescue
Klein, Hannah L
2007 Oct 26;28(2):181-183, Molecular cell
— id: 75480, year: 2007, vol: 28, page: 181, stat: Journal Article,

DNA helicases in recombination
Klein, HL
2007 ;17:1-26, Topics in current genetics
— id: 644362, year: 2007, vol: 17, page: 1, stat: Journal Article,

Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling
Kwon, Youngho; Chi, Peter; Roh, Dong Hyun; Klein, Hannah; Sung, Patrick
2007 Oct 1;6(10):1496-1506, DNA repair (Amsterdam)
— id: 107908, year: 2007, vol: 6, page: 1496, stat: Journal Article,

Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA
Chi, Peter; Kwon, Youngho; Seong, Changhyun; Epshtein, Anastasiya; Lam, Isabel; Sung, Patrick; Klein, Hannah L
2006 Sep 8;281(36):26268-26279, Journal of biological chemistry
— id: 67273, year: 2006, vol: 281, page: 26268, stat: Journal Article,

A SUMOry of DNA replication: synthesis, damage, and repair
Klein, Hannah L
2006 Nov 3;127(3):455-457, Cell
— id: 69601, year: 2006, vol: 127, page: 455, stat: Journal Article,

Mechanism of homologous recombination: mediators and helicases take on regulatory functions
Sung, Patrick; Klein, Hannah
2006 Oct;7(10):739-750, Nature reviews. Molecular cell biology
— id: 107909, year: 2006, vol: 7, page: 739, stat: Journal Article,

Biochemical and genetic characterization of Hmi1p, a yeast DNA helicase involved in the maintenance of mitochondrial DNA
Monroe, Danny S Jr; Leitzel, Adelaide K; Klein, Hannah L; Matson, Steven W
2005 Dec;22(16):1269-1286, Yeast
— id: 67274, year: 2005, vol: 22, page: 1269, stat: Journal Article,

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein
Krejci, Lumir; Macris, Margaret; Li, Ying; Van Komen, Stephen; Villemain, Jana; Ellenberger, Thomas; Klein, Hannah; Sung, Patrick
2004 May 28;279(22):23193-23199, Journal of biological chemistry
— id: 67276, year: 2004, vol: 279, page: 23193, stat: Journal Article,

Effects of tumor-associated mutations on Rad54 functions
Smirnova, Marina; Van Komen, Stephen; Sung, Patrick; Klein, Hannah L
2004 Jun 4;279(23):24081-24088, Journal of biological chemistry
— id: 48199, year: 2004, vol: 279, page: 24081, stat: Journal Article,

Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage
Xu, Hong; Boone, Charles; Klein, Hannah L
2004 Aug;24(16):7082-7090, Molecular & cellular biology
— id: 67275, year: 2004, vol: 24, page: 7082, stat: Journal Article,

DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Krejci, Lumir; Van Komen, Stephen; Li, Ying; Villemain, Jana; Reddy, Mothe Sreedhar; Klein, Hannah; Ellenberger, Thomas; Sung, Patrick
2003 May 15;423(6937):305-309, Nature
— id: 36568, year: 2003, vol: 423, page: 305, stat: Journal Article,

ATPase and DNA Helicase Activities of the Saccharomyces cerevisiae Anti-recombinase Srs2
Van Komen, Stephen; Reddy, Mothe Sreedhar; Krejci, Lumir; Klein, Hannah; Sung, Patrick
2003 Nov 7;278(45):44331-44337, Journal of biological chemistry
— id: 39080, year: 2003, vol: 278, page: 44331, stat: Journal Article,

Replication, recombination, and repair: going for the gold
Klein, Hannah L; Kreuzer, Kenneth N
2002 Mar;9(3):471-480, Molecular cell
— id: 27572, year: 2002, vol: 9, page: 471, stat: Journal Article,

hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae
Merker, Robert J; Klein, Hannah L
2002 Jan;22(2):421-429, Molecular & cellular biology
— id: 26519, year: 2002, vol: 22, page: 421, stat: Journal Article,

High-Copy-Number Expression of Sub2p, a Member of the RNA Helicase Superfamily, Suppresses hpr1-Mediated Genomic Instability
Fan HY; Merker RJ; Klein HL
2001 Aug;21(16):5459-5470, Molecular & cellular biology
— id: 21106, year: 2001, vol: 21, page: 5459, stat: Journal Article,

Mutations in Recombinational Repair and in Checkpoint Control Genes Suppress the Lethal Combination of srs2Delta With Other DNA Repair Genes in Saccharomyces cerevisiae
Klein HL
2001 Feb;157(2):557-565, Genetics
— id: 17562, year: 2001, vol: 157, page: 557, stat: Journal Article,

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast
Hegde V; Klein H
2000 Jul 15;28(14):2779-2783, Nucleic acids research
— id: 11585, year: 2000, vol: 28, page: 2779, stat: Journal Article,

A radical solution to death
Klein HL
2000 Jun;25(2):132-134, Nature genetics
— id: 17414, year: 2000, vol: 25, page: 132, stat: Journal Article,

Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1
Petukhova, G; Sung, P; Klein, H
2000 Sep 1;14(17):2206-2215, Genes & development
— id: 147667, year: 2000, vol: 14, page: 2206, stat: Journal Article,

A novel cold-sensitive allele of the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase, affects the morphology of the yeast vacuole through acylation of Vac8p
Schneiter R; Guerra CE; Lampl M; Tatzer V; Zellnig G; Klein HL; Kohlwein SD
2000 May;20(9):2984-2995, Molecular & cellular biology
— id: 17415, year: 2000, vol: 20, page: 2984, stat: Journal Article,

A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling
Chang M; French-Cornay D; Fan HY; Klein H; Denis CL; Jaehning JA
1999 Feb;19(2):1056-1067, Molecular & cellular biology
— id: 7937, year: 1999, vol: 19, page: 1056, stat: Journal Article,

Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation
Petukhova G; Van Komen S; Vergano S; Klein H; Sung P
1999 Oct 8;274(41):29453-29462, Journal of biological chemistry
— id: 20352, year: 1999, vol: 274, page: 29453, stat: Journal Article,

The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA
Schneiter R; Guerra CE; Lampl M; Gogg G; Kohlwein SD; Klein HL
1999 May;19(5):3415-3422, Molecular & cellular biology
— id: 8509, year: 1999, vol: 19, page: 3415, stat: Journal Article,

Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
Vainberg IE; Lewis SA; Rommelaere H; Ampe C; Vandekerckhove J; Klein HL; Cowan NJ
1998 May 29;93(5):863-873, Cell
— id: 7835, year: 1998, vol: 93, page: 863, stat: Journal Article,

RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
Klein HL
1997 Dec;147(4):1533-1543, Genetics
— id: 12190, year: 1997, vol: 147, page: 1533, stat: Journal Article,

Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae
Fan HY; Cheng KK; Klein HL
1996 Mar;142(3):749-759, Genetics
— id: 8417, year: 1996, vol: 142, page: 749, stat: Journal Article,

1995 MAR 10 ;14(1-6):312-312, Journal of cellular biochemistry
— id: 86748, year: 1995, vol: 14, page: 312, stat: Journal Article,

Examination of mitotic recombination by means of hyper-recombination mutants in Saccharomyces cerevisiae
Klein HL
1995 ;51:271-303, Progress in nucleic acid research & molecular biology
— id: 6836, year: 1995, vol: 51, page: 271, stat: Journal Article,

Genetic control of intrachromosomal recombination
Klein HL
1995 Feb;17(2):147-159, Bioessays
— id: 8064, year: 1995, vol: 17, page: 147, stat: Journal Article,

1995 MAR 10 ;14(1-6):269-269, Journal of cellular biochemistry
— id: 86746, year: 1995, vol: 14, page: 269, stat: Journal Article,

Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae
Fan HY; Klein HL
1994 Aug;137(4):945-956, Genetics
— id: 6612, year: 1994, vol: 137, page: 945, stat: Journal Article,

Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
Rong L; Klein HL
1993 Jan 15;268(2):1252-1259, Journal of biological chemistry
— id: 6501, year: 1993, vol: 268, page: 1252, stat: Journal Article,

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
Palladino F; Klein HL
1992 Sep;132(1):23-37, Genetics
— id: 13469, year: 1992, vol: 132, page: 23, stat: Journal Article,

The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
Rong L; Palladino F; Aguilera A; Klein HL
1991 Jan;127(1):75-85, Genetics
— id: 14195, year: 1991, vol: 127, page: 75, stat: Journal Article,

HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
Aguilera A; Klein HL
1990 Apr;10(4):1439-1451, Molecular & cellular biology
— id: 17418, year: 1990, vol: 10, page: 1439, stat: Journal Article,

Yeast alpha-factor and somatostatin enhance binding of [3H]estradiol to proteins in rat pancreas and Saccharomyces cerevisiae
Grossman, A; Klein, H; Becker, J M; Naider, F
1986 Sep;25(3):299-304, Journal of steroid biochemistry
— id: 99130, year: 1986, vol: 25, page: 299, stat: Journal Article,

Clozapine, chlorpromazine, and placebo in newly hospitalized, acutely schizophrenic patients: a controlled, double-blind comparison
Shopsin, B; Klein, H; Aaronsom, M; Collora, M
1979 Jun;36(6):657-664, Archives of general psychiatry
— id: 104966, year: 1979, vol: 36, page: 657, stat: Journal Article,

Clozapine: double-blind control trial in the treatment of acute schizophrenia [proceedings]
Shopsin, B; Klein, H; Aronson, M
1978 Apr;14(2):12-15, Psychopharmacology bulletin
— id: 104965, year: 1978, vol: 14, page: 12, stat: Journal Article,

Penfluridol: an open phase III study in acute newly admitted hospitalized schizophrenic patients
Shopsin, B; Klein, H; Gerbino, L; Selzer, G
1977 Dec 19;55(2):157-164, Psychopharmacology
— id: 104967, year: 1977, vol: 55,