Biosketch / Results /

David L Kleinberg, M.D.

Professor; Director Neuro Endocrine Unit
Department of Medicine (Endocrinology Div)

Clinical Addresses

530 FIRST AVENUE, 4C
NEW YORK, NY 10016
Phone: 212-263-6772
Fax: 212-447-6219

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Medical Specialties

Endocrinology & Metabolism

Medical Expertise

Neuroendocrine Tumors, Pituitary Disorders, Neuroendocrine

Insurance

Cigna HMO/POS, Cigna PPO, UHC EPO, UHC HMO, UHC POS, UHC PPO, UHC TOP TIER

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1972 — Ab Internal Medicine - Internal Medicine
1975 — Ab Internal Medicine (Endocrinology, Diabetes & Metabolism)

Education

1962-1966 — University of Miami School of Medicine, Medical Education
1966-1967 — Veterans Administration Med. Ctr. (Internal Medicine), Internship
1967-1968 — Maimonides Medical Center (Internal Medicine), Residency Training
1968-1970 — Columbia Presbysterian Medical Center (Endocrinology), Clinical Fellowships
1970-1971 — Columbia-Presbyterian Medical Center (Medicine), Residency Training

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Research Summary

Growth hormone and prolactin are pituitary hormones that are important in normal growth and development and in lactation post-partum. These hormones have protean effects on many cells and organ systems. We showed that development of the mammary gland is controlled initially by growth hormone and that prolactin has an important effect on the mammary gland at later developmental stages. In the absence of growth hormone, mammary development in rats and monkeys does not occur. Normal mammary development occurs at puberty under the influence of growth hormone and estrogen. Our research demonstrates that growth hormone works via the growth hormone receptor and stimulates local production of insulin-like growth factor I (IGF-I) within the mammary gland. That IGF-I then stimulates development of mammary gland terminal end buds and alveolar structures is supported by the fact that IGF-I can substitute for growth hormone in this process. Additionally, animals that are deficient in IGF-I do not have normal mammary development.

Our current work is to further uncover the mechanisms by which growth hormone stimulates mammary development and determine the interaction of hormones in various tissue types within the mammary gland. We hypothesize that a full under-standing of mammary development will help develop treatment for breast cancer.

Research Interests

Growth Hormone and IGF-I in Mammary Development and Breast Cancer

Research Keywords

growth hormone, insulin-like growth factor 1 (IGF-I), mammary development, prolactin

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Growth hormone should be used only for approved indications
Clemmons, David R; Molitch, Mark; Hoffman, Andrew R; Klibanski, Anne; Strasburger, Christian J; Kleinberg, David L; Ho, Ken; Webb, Susan M; Bronstein, Marcello D; Bouillon, Roger; Ben-Shlomo, Anat; Hamrahian, Amir H; Chanson, Philippe; Barkan, Ariel L; Merriam, George R; Blackman, Marc R; Salvatori, Roberto
2014 Feb;99(2):409-411, Journal of clinical endocrinology & metabolism
— id: 806872, year: 2014, vol: 99, page: 409, stat: Journal Article,

Expert consensus document: A consensus on the medical treatment of acromegaly
Giustina, Andrea; Chanson, Philippe; Kleinberg, David; Bronstein, Marcello D; Clemmons, David R; Klibanski, Anne; van der Lely, Aart J; Strasburger, Christian J; Lamberts, Steven W; Ho, Ken K Y; Casanueva, Felipe F; Melmed, Shlomo
2014 Apr;10(4):243-248, Nature reviews. Endocrinology
— id: 851862, year: 2014, vol: 10, page: 243, stat: Journal Article,

Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study
Petersenn, Stephan; Farrall, Andrew J; Block, Christophe; Melmed, Shlomo; Schopohl, Jochen; Caron, Philippe; Cuneo, Ross; Kleinberg, David; Colao, Annamaria; Ruffin, Matthieu; Hermosillo Resendiz, Karina; Hughes, Gareth; Hu, Ke; Barkan, Ariel
2014 Apr;17(2):132-140, Pituitary
— id: 875032, year: 2014, vol: 17, page: 132, stat: Journal Article,

Breast cancer risk in BRCA1 mutation carriers: insight from mouse models
Barcellos-Hoff, M H; Kleinberg, D L
2013 Nov;24 Suppl 8:viii8-viii12, Annals of oncology
— id: 598512, year: 2013, vol: 24 Suppl 8, page: viii8, stat: Journal Article,

A panoramic view of the skull base: systematic review of open and endoscopic endonasal approaches to four tumors
Graffeo, Christopher S; Dietrich, August R; Grobelny, Bartosz; Zhang, Meng; Goldberg, Judith D; Golfinos, John G; Lebowitz, Richard; Kleinberg, David; Placantonakis, Dimitris G
2013 Sep;:?-?, Pituitary
— id: 590322, year: 2013, vol: , page: ?, stat: Journal Article,

Prospective Safety Surveillance of GH-Deficient Adults: Comparison of GH-Treated vs Untreated Patients
Hartman, Mark L; Xu, Rong; Crowe, Brenda J; Robison, Leslie L; Erfurth, Eva Marie; Kleinberg, David L; Zimmermann, Alan G; Woodmansee, Whitney W; Cutler, Gordon B Jr; Chipman, John J; Melmed, Shlomo
2013 Mar;98(3):980-988, Journal of clinical endocrinology & metabolism
— id: 287852, year: 2013, vol: 98, page: 980, stat: Journal Article,

Igf-I inhibition by pasireotide reverses the mammary phenotype of a novel mouse model of Brca1 deficiency
Ameri, P; Fernandez-Garcia, I; Martinez-Ruiz, H; De, Angelis C; Barcellos-Hoff, M H; Kleinberg, D L
2012 June 2012;33(3):-, Endocrine reviews
— id: 175839, year: 2012, vol: 33, page: , stat: Journal Article,

Alternative approach to insulin-like growth factor-1 inhibition for treatment of breast cancer
Ameri, Pietro; Danoff, Ann; Kleinberg, David L
2012 Apr;30(12):1395-6; author reply 1396, Journal of clinical oncology
— id: 165608, year: 2012, vol: 30, page: 1395, stat: Journal Article,

Inhibition of IGF-1 suppress genomic instability and epithelial lineage aberrations in the mammary gland of BRCA1 deficient mice
Fernandez-Garcia, I; Ameri, P; Barcellos-Hoff, M H; Kleinberg, D L
2012 15 Apr 2012;72(8):-, Cancer research
— id: 422462, year: 2012, vol: 72, page: , stat: Journal Article,

Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
Tuvia, S; Atsmon, J; Teichman, S L; Katz, S; Salama, P; Pelled, D; Landau, I; Karmeli, I; Bidlingmaier, M; Strasburger, C J; Kleinberg, D L; Melmed, S; Mamluk, R
2012 Jul;97(7):2362-2369, Journal of clinical endocrinology & metabolism
— id: 174447, year: 2012, vol: 97, page: 2362, stat: Journal Article,

Pasireotide, an IGF-I action inhibitor, prevents growth hormone and estradiol-induced mammary hyperplasia
Kleinberg, David L; Ameri, Pietro; Singh, Baljit
2011 Mar;14(1):44-52, Pituitary
— id: 123203, year: 2011, vol: 14, page: 44, stat: Journal Article,

The pivotal role of insulin-like growth factor I in normal mammary development
Kleinberg, David L; Barcellos-Hoff, Mary Helen
2011 Sep;40(3):193-204, Endocrinology & metabolism clinics of North America
— id: 137076, year: 2011, vol: 40, page: 193, stat: Journal Article,

Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
Melmed, Shlomo; Casanueva, Felipe F; Hoffman, Andrew R; Kleinberg, David L; Montori, Victor M; Schlechte, Janet A; Wass, John A H
2011 Feb;96(2):273-288, Journal of clinical endocrinology & metabolism
— id: 134162, year: 2011, vol: 96, page: 273, stat: Journal Article,

Moderate doses of hGH (0.64 mg/d) improve lipids but not cardiovascular function in GH-deficient adults with normal baseline cardiac function
Newman, Connie B; Frisch, Katalin A; Rosenzweig, Barry; Roubenoff, Ronenn; Rey, Mariano; Kidder, Teresa; Kong, Yuan; Pursnani, Amit; Sedlis, Steven P; Schwartzbard, Arthur; Kleinberg, David L
2011 Jan;96(1):122-132, Journal of clinical endocrinology & metabolism
— id: 138237, year: 2011, vol: 96, page: 122, stat: Journal Article,

Prevention of breast cancer: the case for studying inhibition of IGF-1 actions
Smith, J; Axelrod, D; Singh, B; Kleinberg, D
2011 Jan;22 Suppl 1:i50-i52, Annals of oncology
— id: 134119, year: 2011, vol: 22 Suppl 1, page: i50, stat: Journal Article,

Prevalence of metabolic syndrome in adult hypopituitary growth hormone (GH)-deficient patients before and after GH replacement
Attanasio, Andrea F; Mo, Daojun; Erfurth, Eva Marie; Tan, Meng; Ho, Ken Y; Kleinberg, David; Zimmermann, Alan G; Chanson, Philippe
2010 Jan;95(1):74-81, Journal of clinical endocrinology & metabolism
— id: 134971, year: 2010, vol: 95, page: 74, stat: Journal Article,

Development of an Acromegaly Registry To Follow Treatment
Sood, M.; Benaviv-Meskin, D.; Heron-Chaturvedi, D. C.; Lowy, N.; Narayan, N. R.; Lesser, M. L.; Escalon, L. B.; Martocci, A. S.; Levitt, H. B.; Kleinberg, D. L.
2010 JUN ;31(3):-, Endocrine reviews
— id: 128834, year: 2010, vol: 31, page: , stat: Journal Article,

Breast Cancer Chemoprevention in Pre-Neoplastic Lesions with a Somatostatin Analog in Nine Women: A Proof of Principle Trial
Axelrod, D; Smith, JA; Singh, B; Ruan, W; Lubitz, S; Kleinberg, DL
2009 DEC 15 ;69(24):552S-552S, Cancer research
— id: 106452, year: 2009, vol: 69, page: 552S, stat: Journal Article,

Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
Kleinberg, David L; Wood, Teresa L; Furth, Priscilla A; Lee, Adrian V
2009 Feb;30(1):51-74, Endocrine reviews
— id: 95722, year: 2009, vol: 30, page: 51, stat: Journal Article,

Guidelines for Acromegaly Management: An Update
Melmed, S; Colao, A; Barkan, A; Molitch, M; Grossman, AB; Kleinberg, D; Clemmons, D; Chanson, P; Laws, E; Schlechte, J; Vance, ML; Ho, K; Giustina, A
2009 MAY ;94(5):1509-1517, Journal of clinical endocrinology & metabolism
— id: 99176, year: 2009, vol: 94, page: 1509, stat: Journal Article,

Evidence that SOM230 can prevent experimental mammary hyperplasia by blocking IGF-I and thus estrogen action in the mammary gland: preliminary evidence for an effect in humans
Ruan, W; Singh, B; Smith, J; Axelrod, D; Kleinberg, DL
2009 ;69(2):325S-326S, Cancer research
— id: 93515, year: 2009, vol: 69, page: 325S, stat: Journal Article,

Pregnancy outcomes following cabergoline treatment: extended results from a 12-year observational study
Colao, Annamaria; Abs, Roger; Barcena, David Gonzalez; Chanson, Philippe; Paulus, Wolfgang; Kleinberg, David L
2008 Jan;68(1):66-71, Clinical endocrinology
— id: 95723, year: 2008, vol: 68, page: 66, stat: Journal Article,

IGF-I, GH, and sex steroid effects in normal mammary gland development
Kleinberg, David L; Ruan, Weifeng
2008 Dec;13(4):353-360, Journal of mammary gland biology & neoplasia
— id: 91490, year: 2008, vol: 13, page: 353, stat: Journal Article,

Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas. [Spanish]
Casanueva F.F.; Molitch M.E.; Schlechte J.A.; Abs R.; Bonert V.; Bronstein M.D.; Brue T.; Cappabianca P.; Colao A.; Fahlbusch R.; Fideleff H.; Hadani M.; Kelly P.; Kleinberg D.; Laws E.; Marek J.; Scanlon M.; Sobrinho L.G.; Wass J.A.H.; Giustina A.
2007 ;54(8):438.e1-438.e10, Endocrinologia y Nutricion
— id: 74878, year: 2007, vol: 54, page: 438.e1, stat: Journal Article,

Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice
Kleinberg, David L; Ruan, Weifeng; Yee, Douglas; Kovacs, Kalman T; Vidal, Sergio
2007 Mar;148(3):1080-1088, Endocrinology
— id: 71336, year: 2007, vol: 148, page: 1080, stat: Journal Article,

GH peak response to GHRH-arginine: relationship to insulin resistance and other cardiovascular risk factors in a population of adults aged 50-90
Carmichael, John D; Danoff, Ann; Milani, Daniela; Roubenoff, Ronenn; Lesser, Martin L; Livote, Elayne; Reitz, Richard E; Ferris, Steven; Kleinberg, David L
2006 Aug;65(2):169-177, Clinical endocrinology
— id: 95724, year: 2006, vol: 65, page: 169, stat: Journal Article,

Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas
Casanueva, FF; Molitch, ME; Schlechte, JA; Abs, R; Bonert, V; Bronstein, MD; Brue, T; Cappabianca, P; Colao, A; Fahlbusch, R; Fideleff, H; Hadani, M; Kelly, P; Kleinberg, D; Laws, E; Marek, J; Scanlon, M; Sobrinho, LG; Wass, JAH; Giustina, A
2006 AUG ;65(2):265-273, Clinical endocrinology
— id: 98071, year: 2006, vol: 65, page: 265, stat: Journal Article,

SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?
Ruan, Weifeng; Fahlbusch, Fabian; Clemmons, David R; Monaco, Marie E; Walden, Paul D; Silva, Antonio P; Schmid, Herbert A; Kleinberg, David L
2006 Feb;20(2):426-436, Molecular endocrinology
— id: 64154, year: 2006, vol: 20, page: 426, stat: Journal Article,

New roles and challenges in neurosurgery of acromegaly
Kleinberg, D L
2005 ;28(5 Suppl):88-91, Journal of endocrinological investigation
— id: 58982, year: 2005, vol: 28, page: 88, stat: Journal Article,

Primary therapy for acromegaly with somatostatin analogs and a discussion of novel peptide analogs
Kleinberg, David L
2005 Jan;6(1):29-37, Reviews in endocrine & metabolic disorders
— id: 56072, year: 2005, vol: 6, page: 29, stat: Journal Article,

Consensus statement: medical management of acromegaly
Melmed, S; Casanueva, F; Cavagnini, F; Chanson, P; Frohman, L A; Gaillard, R; Ghigo, E; Ho, K; Jaquet, P; Kleinberg, D; Lamberts, S; Laws, E; Lombardi, G; Sheppard, M C; Thorner, M; Vance, M L; Wass, J A H; Giustina, A
2005 Dec;153(6):737-740, European journal of endocrinology
— id: 653852, year: 2005, vol: 153, page: 737, stat: Journal Article,

A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly
Melmed, Shlomo; Sternberg, Richard; Cook, David; Klibanski, Anne; Chanson, Philippe; Bonert, Vivien; Vance, Mary Lee; Rhew, David; Kleinberg, David; Barkan, Ariel
2005 Jul;90(7):4405-4410, Journal of clinical endocrinology & metabolism
— id: 63408, year: 2005, vol: 90, page: 4405, stat: Journal Article,

Progesterone stimulates mammary gland ductal morphogenesis by synergizing with and enhancing insulin-like growth factor-I action
Ruan, Weifeng; Monaco, Marie E; Kleinberg, David L
2005 Mar;146(3):1170-1178, Endocrinology
— id: 50630, year: 2005, vol: 146, page: 1170, stat: Journal Article,

AACE Medical Guidelines for Clinical Practice for the diagnosis and treatment of acromegaly
Cook, David M; Ezzat, Shereen; Katznelson, Laurence; Kleinberg, David L; Laws, Edward R Jr; Nippoldt, Todd B; Swearingen, Brooke; Vance, Mary Lee
2004 May-Jun;10(3):213-225, Endocrine practice
— id: 95725, year: 2004, vol: 10, page: 213, stat: Journal Article,

Growth hormone (GH) replacement therapy in adult-onset GH deficiency: Effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
Hoffman, AR; Kuntze, JE; Baptista, J; Baum, HBA; Baumann, GP; Biller, BMK; Clark, RV; Cook, D; Inzucchi, SE; Kleinberg, D; Klibanski, A; Phillips, LS; Ridgway, EC; Robbins, RJ; Schlechte, J; Sharma, M; Thorner, MO; Vance, ML
2004 MAY ;89(5):2048-2056, Journal of clinical endocrinology & metabolism
— id: 46639, year: 2004, vol: 89, page: 2048, stat: Journal Article,

Variability and reliability of single serum IGF-I measurements: impact on determining predictability of risk ratios in disease development
Milani, Daniela; Carmichael, John D; Welkowitz, Joan; Ferris, Steven; Reitz, Richard E; Danoff, Ann; Kleinberg, David L
2004 May;89(5):2271-2274, Journal of clinical endocrinology & metabolism
— id: 44925, year: 2004, vol: 89, page: 2271, stat: Journal Article,

Lipid metabolism in phosphatidylinositol transfer protein alpha-deficient vibrator mice
Monaco, Marie E; Kim, James; Ruan, WeiFeng; Wieczorek, Rosemary; Kleinberg, David L; Walden, Paul D
2004 Apr 30;317(2):444-450, Biochemical & biophysical research communications
— id: 44926, year: 2004, vol: 317, page: 444, stat: Journal Article,

Workshop B: androgens for men and women - new insights
Allolio, B; Kleinberg, D L
2003 Aug;13 Suppl A(12):S62-S62, Growth hormone & IGF research
— id: 44928, year: 2003, vol: 13 Suppl A, page: S62, stat: Journal Article,

Somatostatin analogs as primary medical therapy for acromegaly
Danoff, Ann; Kleinberg, David
2003 Apr;20(3):291-297, Endocrine
— id: 37966, year: 2003, vol: 20, page: 291, stat: Journal Article,

Diagnosis and treatment of acromegaly complications
Giustina, A; Casanueva, F F; Cavagnini, F; Chanson, P; Clemmons, D; Frohman, L A; Gaillard, R; Ho, K; Jaquet, P; Kleinberg, D L; Lamberts, S W J; Lombardi, G; Sheppard, M; Strasburger, C J; Vance, M L; Wass, J A H; Melmed, S
2003 Dec;26(12):1242-1247, Journal of endocrinological investigation
— id: 44927, year: 2003, vol: 26, page: 1242, stat: Journal Article,

Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency
Biller, Beverly M K; Samuels, Mary H; Zagar, Anthony; Cook, David M; Arafah, Baha M; Bonert, Vivien; Stavrou, Stavros; Kleinberg, David L; Chipman, John J; Hartman, Mark L
2002 May;87(5):2067-2079, Journal of clinical endocrinology & metabolism
— id: 44929, year: 2002, vol: 87, page: 2067, stat: Journal Article,

Guidelines for acromegaly management
Melmed, S; Casanueva, FF; Cavagnini, F; Chanson, P; Frohman, L; Grossman, A; Ho, K; Kleinberg, D; Lamberts, S; Laws, E; Lombardi, G; Vance, ML; Von Werder, K; Wass, J; Giustina, A
2002 Sep;87(9):4054-4058, Journal of clinical endocrinology & metabolism
— id: 32443, year: 2002, vol: 87, page: 4054, stat: Journal Article,

Hypogonadism in patients with acromegaly: data from the multi-centre acromegaly registry pilot study
Katznelson L; Kleinberg D; Vance ML; Stravou S; Pulaski KJ; Schoenfeld DA; Hayden DL; Wright ME; Woodburn CJ; Klibanski A
2001 Feb;54(2):183-188, Clinical endocrinology
— id: 18388, year: 2001, vol: 54, page: 183, stat: Journal Article,

State-of-the-art strategies for the diagnosis and management of acromegaly
Klibanski, A; Ho, K; Freda, PU; Clemmons, DR; Barkan, AL; Kleinberg, DL; Trainer, PJ; Swearingen, B; Molitch, ME; Wass, JAH; Thorner, MO; Melmed, S; Strasburger, CJ; Frohman, LA
2001 MAY-JUN ;11(3):223-232, Endocrinologist
— id: 55041, year: 2001, vol: 11, page: 223, stat: Journal Article,

Diagnosis and management of growth hormone deficiency in adults
Stavrou S; Kleinberg DL
2001 Sep;30(3):545-563, Endocrinology & metabolism clinics of North America
— id: 39481, year: 2001, vol: 30, page: 545, stat: Journal Article,

Rheumatic manifestations of pituitary tumors
Stavrou, S; Kleinberg, D L
2001 Oct;3(5):459-463, Current rheumatology reports
— id: 111711, year: 2001, vol: 3, page: 459, stat: Journal Article,

IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis
Kleinberg DL; Feldman M; Ruan W
2000 Jan;5(1):7-17, Journal of mammary gland biology & neoplasia
— id: 11724, year: 2000, vol: 5, page: 7, stat: Journal Article,

Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
Trainer, PJ; Drake, WM; Katznelson, L; Freda, PU; Herman-Bonert, V; van der Lely, AJ; Dimaraki, EV; Stewart, PM; Friend, KE; Vance, ML; Besser, GM; Scarlett, JA; Thorner, MO; Parkinson, C; Klibanski, A; Powell, JS; Barkan, AL; Sheppard, MC; Maldonado, M; Rose, DR; Clemmons, DR; Johannson, G; Bengtsson, BA; Stavrou, S; Kleinberg, DL; Cook, DM; Phillips, LS; Bidlingmaier, M; Strasburger, CJ; Hackett, S; Zib, K; Bennett, WF; Davis, RJ
2000 APR 20 ;342(16):1171-1177, New England journal of medicine
— id: 54714, year: 2000, vol: 342, page: 1171, stat: Journal Article,

The effect of GH on estrogen receptor expression in the rat mammary gland
Feldman M; Ruan W; Tappin I; Wieczorek R; Kleinberg DL
1999 Dec;163(3):515-522, Journal of endocrinology
— id: 8597, year: 1999, vol: 163, page: 515, stat: Journal Article,

Prolactin levels and adverse events in patients treated with risperidone
Kleinberg DL; Davis JM; de Coster R; Van Baelen B; Brecher M
1999 Feb;19(1):57-61, Journal of clinical psychopharmacology
— id: 7373, year: 1999, vol: 19, page: 57, stat: Journal Article,

Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development
Ruan W; Kleinberg DL
1999 Nov;140(11):5075-5081, Endocrinology
— id: 11939, year: 1999, vol: 140, page: 5075, stat: Journal Article,

Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development
Ruan W; Powell-Braxton L; Kopchick JJ; Kleinberg DL
1999 May;140(5):1984-1989, Endocrinology
— id: 12020, year: 1999, vol: 140, page: 1984, stat: Journal Article,

Role of IGF-I in normal mammary development
Kleinberg DL
1998 Feb;47(3):201-208, Breast cancer research & treatment
— id: 57178, year: 1998, vol: 47, page: 201, stat: Journal Article,

Current treatment guidelines for acromegaly
Melmed, S; Jackson, I; Kleinberg, D; Klibanski, A
1998 Aug;83(8):2646-2652, Journal of clinical endocrinology & metabolism
— id: 636532, year: 1998, vol: 83, page: 2646, stat: Journal Article,

Octreotide as primary therapy for acromegaly
Newman CB; Melmed S; George A; Torigian D; Duhaney M; Snyder P; Young W; Klibanski A; Molitch ME; Gagel R; Sheeler L; Cook D; Malarkey W; Jackson I; Vance ML; Barkan A; Frohman L; Kleinberg DL
1998 Sep;83(9):3034-3040, Journal of clinical endocrinology & metabolism
— id: 57219, year: 1998, vol: 83, page: 3034, stat: Journal Article,

Adult growth hormone deficiency
Newman, CB; Kleinberg, DL
1998 MAY ;8(3):178-186, Endocrinologist
— id: 53450, year: 1998, vol: 8, page: 178, stat: Journal Article,

Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development
Walden PD; Ruan W; Feldman M; Kleinberg DL
1998 Feb;139(2):659-662, Endocrinology
— id: 7840, year: 1998, vol: 139, page: 659, stat: Journal Article,

Early mammary development: growth hormone and IGF-1
Kleinberg DL
1997 Jan;2(1):49-57, Journal of mammary gland biology & neoplasia
— id: 11608, year: 1997, vol: 2, page: 49, stat: Journal Article,

Pharmacological therapies and surgical options in the treatment of hyperprolactinemia
Kleinberg, DL
1997 SEP-OCT ;7(5):379-384, Endocrinologist
— id: 53174, year: 1997, vol: 7, page: 379, stat: Journal Article,

A novel whey to study effects of insulin-like growth factor-I on mammary development
Kleinberg DL
1996 Jan;137(1):1-2, Endocrinology
— id: 18390, year: 1996, vol: 137, page: 1, stat: Journal Article,

Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study
Wang C; Eyre DR; Clark R; Kleinberg D; Newman C; Iranmanesh A; Veldhuis J; Dudley RE; Berman N; Davidson T; Barstow TJ; Sinow R; Alexander G; Swerdloff RS
1996 Oct;81(10):3654-3662, Journal of clinical endocrinology & metabolism
— id: 18389, year: 1996, vol: 81, page: 3654, stat: Journal Article,

Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid
Ruan, W; Catanese, V; Wieczorek, R; Feldman, M; Kleinberg, D L
1995 Mar;136(3):1296-1302, Endocrinology
— id: 138562, year: 1995, vol: 136, page: 1296, stat: Journal Article,

Galactorrhea
Kleinberg DL
1994 ;5:360-364, Current therapy in endocrinology & metabolism
— id: 13040, year: 1994, vol: 5, page: 360, stat: Journal Article,

Visual loss in pregnant women with pituitary adenomas [see comments]
Kupersmith MJ; Rosenberg C; Kleinberg D
1994 Oct 1;121(7):473-477, Annals of internal medicine
— id: 6666, year: 1994, vol: 121, page: 473, stat: Journal Article,

Identification of rat liver phosphatidylinositol synthase as a 21 kDa protein
Monaco ME; Feldman M; Kleinberg DL
1994 Nov 15;304 ( Pt 1):301-305, Biochemical journal
— id: 56687, year: 1994, vol: 304 ( Pt 1), page: 301, stat: Journal Article,

P53 PROTEIN OVEREXPRESSION IN MALE BREAST-CANCER - CLINICOPATHOLOGICAL (CPC) CORRELATION
WIECZOREK, R; HELLER, P; FEINER, H; SIDHU, G; DEMOPOULOS, R; JAGIRDAR, J; KLEINBERG, D; FELDMAN, M; SUHRLAND, M
1994 ;70(Suppl 1):A24-A24, Laboratory investigation
— id: 52574, year: 1994, vol: 70, page: A24, stat: Journal Article,

Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland
Feldman M; Ruan W; Cunningham BC; Wells JA; Kleinberg DL
1993 Oct;133(4):1602-1608, Endocrinology
— id: 8218, year: 1993, vol: 133, page: 1602, stat: Journal Article,

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development
Ruan W; Newman CB; Kleinberg DL
1992 Nov 15;89(22):10872-10876, Proceedings of the National Academy of Sciences of the United States of America
— id: 18391, year: 1992, vol: 89, page: 10872, stat: Journal Article,

Ovarian control of pituitary hormone secretion in early human pregnancy
Emmi AM; Skurnick J; Goldsmith LT; Gagliardi CL; Schmidt CL; Kleinberg D; Weiss G
1991 Jun;72(6):1359-1363, Journal of clinical endocrinology & metabolism
— id: 25517, year: 1991, vol: 72, page: 1359, stat: Journal Article,

FINE NEEDLE ASPIRATION (FNA) OF PRIMARY BREAST-CARCINOMA FOR FLOW CYTOMETRIC (FCM) DNA ANALYSIS
Eliasen, C; Opitz, L; Rizk, C; Vamvakas, E; Kleinberg, D; Roses, D; Harris, M; Feiner, H
1990 ;62(Suppl 1):A30-A30, Laboratory investigation
— id: 32017, year: 1990, vol: 62, page: A30, stat: Journal Article,

Non-lactogenic effects of growth hormone on growth and insulin-like growth factor-I messenger ribonucleic acid of rat mammary gland
Kleinberg DL; Ruan W; Catanese V; Newman CB; Feldman M
1990 Jun;126(6):3274-3276, Endocrinology
— id: 18392, year: 1990, vol: 126, page: 3274, stat: Journal Article,

GROWTH-HORMONE (GH) IS A MORE POTENT MAMMARY MITOGEN THAN PROLACTIN (PRL) INVIVO
RUAN, WF; FELDMAN, M; NEWMAN, CB; KLEINBERG, DL
1990 APR ;38(2):A343-A343, Clinical research
— id: 98508, year: 1990, vol: 38, page: A343, stat: Journal Article,

Growth of prolactinoma despite lowering of serum prolactin by bromocriptine
Kupersmith MJ; Kleinberg D; Warren FA; Budzilovitch G; Cooper P
1989 Mar;24(3):417-423, Neurosurgery
— id: 10699, year: 1989, vol: 24, page: 417, stat: Journal Article,

Effect of CV 205-502 in hyperprolactinaemic patients intolerant of bromocriptine
Newman CB; Hurley AM; Kleinberg DL
1989 Oct;31(4):391-400, Clinical endocrinology
— id: 18393, year: 1989, vol: 31, page: 391, stat: Journal Article,

Isolation and characterization of monoclonal antibodies against ribonuclease inhibitor
Feldman M; Kohtz DS; Kleinberg DL
1988 Nov 30;157(1):286-294, Biochemical & biophysical research communications
— id: 10883, year: 1988, vol: 157, page: 286, stat: Journal Article,

Prolactin and breast cancer
Kleinberg, D L
1987 Jan;316(5):269-271, New England journal of medicine
— id: 583472, year: 1987, vol: 316, page: 269, stat: Journal Article,

PROLACTIN AND BREAST-CANCER
Kleinberg, DL
1987 Jan 29;316(5):269-271, New England journal of medicine
— id: 31285, year: 1987, vol: 316, page: 269, stat: Journal Article,

Evidence for a nonprolactin, non-growth-hormone mammary mitogen in the human pituitary gland
Newman CB; Cosby H; Friesen HG; Feldman M; Cooper P; De Crescito V; Pilon M; Kleinberg DL
1987 Nov;84(22):8110-8114, Proceedings of the National Academy of Sciences of the United States of America
— id: 18394, year: 1987, vol: 84, page: 8110, stat: Journal Article,

The pituitary gland in primate mammary development: evidence that prolactin is not essential
Kleinberg DL; Newman CB
1986 ;464(22):37-43, Annals of the New York Academy of Sciences
— id: 18395, year: 1986, vol: 464, page: 37, stat: Journal Article,

NOVEL HUMAN PITUITARY FACTORS STIMULATE GROWTH OF MAMMARY-CANCER CELLS AND NORMAL MAMMARY-GLAND
NEWMAN, CB; COSBY, H; FRIESEN, H; STAMPFER, M; MONACO, ME; KLEINBERG, DL
1986 APR ;34(2):A645-A645, Clinical research
— id: 41408, year: 1986, vol: 34, page: A645, stat: Journal Article,

Decreased prolactin secretion in childhood obesity
AvRuskin, T W; Pillai, S; Kasi, K; Juan, C; Kleinberg, D L
1985 Mar;106(3):373-378, Journal of pediatrics
— id: 122850, year: 1985, vol: 106, page: 373, stat: Journal Article,

Primate mammary development. Effects of hypophysectomy, prolactin inhibition, and growth hormone administration
Kleinberg DL; Niemann W; Flamm E; Cooper P; Babitsky G; Valensi Q
1985 Jun;75(6):1943-1950, Journal of clinical investigation
— id: 33566, year: 1985, vol: 75, page: 1943, stat: Journal Article,

COMPUTED-TOMOGRAPHY OF HYPERPROLACTINEMIA UNDER TREATMENT WITH PERGOLIDE
GEORGE, AE; KLEINBERG, DL; FRANTZ, AG; BOYD, AE; WARDLAW, S; GREISING, J; SELTZER, T
1983 ;7(1):193-193, Journal of computer assisted tomography
— id: 40744, year: 1983, vol: 7, page: 193, stat: Journal Article,

Pergolide for the treatment of pituitary tumors secreting prolactin or growth hormone
Kleinberg, D L; Boyd, A E 3rd; Wardlaw, S; Frantz, A G; George, A; Bryan, N; Hilal, S; Greising, J; Hamilton, D; Seltzer, T; Sommers, C J
1983 Sep;309(12):704-709, New England journal of medicine
— id: 734372, year: 1983, vol: 309, page: 704, stat: Journal Article,

Inhibition by estradiol of the lactogenic effect of prolactin in primate mammary tissue: reversal by antiestrogens LY 156758 and tamoxifen
Kleinberg, D L; Todd, J; Babitsky, G
1983 Jul;80(13):4144-4148, Proceedings of the National Academy of Sciences of the United States of America
— id: 163380, year: 1983, vol: 80, page: 4144, stat: Journal Article,

ANTAGONISM OF PROLACTIN STIMULATED LACTOGENESIS IN PRIMATE MAMMARY TISSUE BY ESTRADIOL - A NEW FUNCTION FOR ESTROGENS IN MAMMARY PHYSIOLOGY
KLEINBERG, DL; TODD, J; BABITSKY, G
1983 JAN 20 ;31(2):A471-A471, Clinical research
— id: 98615, year: 1983, vol: 31, page: A471, stat: Journal Article,

ESTRADIOL INHIBITS PROLACTIN INDUCED ALPHA-LACTALBUMIN PRODUCTION IN NORMAL PRIMATE MAMMARY TISSUE INVITRO
Kleinberg, DL; Todd, J; Babitsky, G; Greising, J
1982 ;110(1):279-281, Endocrinology
— id: 30589, year: 1982, vol: 110, page: 279, stat: Journal Article,

Immunohistochemical and electron-microscopic studies of functional and non-functional pituitary adenomas including one TSH secreting tumor in a thyrotoxic patient
Cravioto, H; Fukaya, T; Zimmerman, E A; Kleinberg, D L; Flamm, E S
1981 ;53(4):281-292, Acta neuropathologica
— id: 118103, year: 1981, vol: 53, page: 281, stat: Journal Article,

A double-blind comparison of trebenzomine and thioridazine in the treatment of schizophrenia
Georgotas A; Gerbino L; Jordan B; McCarthy M; Gershon S; Kleinberg D; Lautin A; Stanley M; Rotrosen J
1981 ;73(3):292-294, Psychopharmacology
— id: 23647, year: 1981, vol: 73, page: 292, stat: Journal Article,

Treatment of advanced Parkinson disease with pergolide
Lieberman, A; Goldstein, M; Leibowitz, M; Neophytides, A; Kupersmith, M; Pact, V; Kleinberg, D
1981 Jun;31(6):675-682, Neurology
— id: 122222, year: 1981, vol: 31, page: 675, stat: Journal Article,

Lisuride in Parkinson disease: efficacy of lisuride compared to levodopa
Lieberman, A; Goldstein, M; Neophytides, A; Kupersmith, M; Leibowitz, M; Zasorin, N; Walker, R; Kleinberg, D
1981 Aug;31(8):961-965, Neurology
— id: 122221, year: 1981, vol: 31, page: 961, stat: Journal Article,

Pergolide mesylate: a potent day-long inhibitor of prolactin in rhesus monkeys and patients with Parkinson's disease
Kleinberg, D L; Lieberman, A; Todd, J; Greising, J; Neophytides, A; Kupersmith, M
1980 Jul;51(1):152-154, Journal of clinical endocrinology & metabolism
— id: 122225, year: 1980, vol: 51, page: 152, stat: Journal Article,

EVIDENCE THAT HUMAN GROWTH-HORMONE IS A POTENT LACTOGEN IN PRIMATES
Kleinberg, DL; Todd, J
1980 ;51(5):1009-1013, Journal of clinical endocrinology & metabolism
— id: 28060, year: 1980, vol: 51, page: 1009, stat: Journal Article,

EFFECT OF PRL INHIBITION BY PERGOLIDE ON MONKEY MAMMARY-GLANDS
Kleinberg, DL; Todd, J; Niemann, W; Greising, J
1980 ;28(2):A480-A480, Clinical research
— id: 28117, year: 1980, vol: 28, page: A480, stat: Journal Article,

LISURIDE IN PARKINSONS-DISEASE
LIEBERMAN, AN; NEOPHYTIDES, A; LEIBOWITZ, M; KUPERSMITH, M; WALKER, R; ZASORIN, N; KLEINBERG, D; GOLDSTEIN, M
1980 ;27(2):266-267, Clinical pharmacology & therapeutics
— id: 575322, year: 1980, vol: 27, page: 266, stat: Journal Article,

Metoclopramide: antipsychotic efficacy of a drug lacking potency in receptor models
Stanley M; Lautin A; Rotrosen J; Gershon S; Kleinberg D
1980 ;71(3):219-225, Psychopharmacology
— id: 23655, year: 1980, vol: 71, page: 219, stat: Journal Article,

Pituitary tumors and failure of endocrine target organs
Kleinberg, D L
1979 Sep;139(9):969-970, Archives of internal medicine
— id: 578122, year: 1979, vol: 139, page: 969, stat: Journal Article,

PITUITARY-TUMORS AND FAILURE OF ENDOCRINE TARGET ORGANS
Kleinberg, DL
1979 ;139(9):969-970, Archives of internal medicine
— id: 30081, year: 1979, vol: 139, page: 969, stat: Journal Article,

PROLACTIN IS LACTOGENIC IN BREAST-TISSUE OF IMMATURE PRIMATES
Kleinberg, DL; Todd, J
1979 ;27(2):A450-A450, Clinical research
— id: 30123, year: 1979, vol: 27, page: A450, stat: Journal Article,

EVIDENCE THAT PROLACTIN STIMULATES ALPHA-LACTALBUMIN PRODUCTION IN MAMMARY TISSUES FROM PRE-MENARCHEAL RHESUS-MONKEYS
Kleinberg, DL; Todd, J; Niemann, W
1979 ;104(6):1569-1573, Endocrinology
— id: 29733, year: 1979, vol: 104, page: 1569, stat: Journal Article,

Pergolide and lisuride for Parkinson's disease
Lieberman, A N; Leibowitz, M; Neophytides, A; Kupersmith, M; Mehl, S; Kleinberg, D; Serby, M; Goldstein, M
1979 Nov 24;2(8152):1129-1130, Lancet
— id: 122227, year: 1979, vol: 2, page: 1129, stat: Journal Article,

PATHOPHYSIOLOGY OF HYPERPROLACTINEMIC STATES AND ROLE OF NEWER ERGOT COMPOUNDS IN THEIR TREATMENT
FRANTZ, AG; KLEINBERG, DL
1978 ;37(8):2192-2197, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 40041, year: 1978, vol: 37, page: 2192, stat: Journal Article,

STUDIES WITH LERGOTRILE MESYLATE IN ACROMEGALY
KLEINBERG, DL; SCHAAF, M; FRANTZ, AG
1978 ;37(8):2198-2201, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 40042, year: 1978, vol: 37, page: 2198, stat: Journal Article,

ALPHA-LACTALBUMIN IN HUMAN AND SUBHUMAN PRIMATE NORMAL MAMMARY TISSUE AND IN HUMAN BREAST-CANCER AS A MARKER FOR PROLACTIN ACTIVITY
KLEINBERG, DL; TODD, J
1978 ;38(11):4318-4322, Cancer research
— id: 40034, year: 1978, vol: 38, page: 4318, stat: Journal Article,

PROLACTIN STIMULATION OF ALPHA-LACTALBUMIN IN NORMAL PRIMATE MAMMARY-GLAND
KLEINBERG, DL; TODD, J; NIEMANN, W
1978 ;47(2):435-441, Journal of clinical endocrinology & metabolism
— id: 98678, year: 1978, vol: 47, page: 435, stat: Journal Article,

Dopaminergic agonist properties of ephedrine--theoretical implications
Angrist B; Rotrosen J; Kleinberg D; Merriam V; Gershon S
1977 Dec 19;55(2):115-120, Psychopharmacology
— id: 23669, year: 1977, vol: 55, page: 115, stat: Journal Article,

GALACTORRHEA - STUDY OF 235 CASES, INCLUDING 48 WITH PITUITARY TUMORS
Kleinberg, DL; Noel, GL; Frantz, AG
1977 ;296(11):589-600, New England journal of medicine
— id: 29550, year: 1977, vol: 296, page: 589, stat: Journal Article,

IMPLICATIONS OF CIRCULATING PROLACTIN - REPLY
KLEINBERG, DL; NOEL, GL; FRANTZ, AG
1977 ;297(1):55-56, New England journal of medicine
— id: 39954, year: 1977, vol: 297, page: 55, stat: Journal Article,

STUDIES ON HUMAN ALPHA-LACTALBUMIN - RADIOIMMUNOASSAY MEASUREMENTS IN NORMAL HUMAN BREAST AND BREAST-CANCER
KLEINBERG, DL; TODD, J; GROVES, ML
1977 ;45(6):1238-1250, Journal of clinical endocrinology & metabolism
— id: 50013, year: 1977, vol: 45, page: 1238, stat: Journal Article,

POSITIVE FEEDBACK OF ESTROGEN ON LH-SECRETION IN WOMEN ON NEUROLEPTIC DRUGS
Weiss, G; Schmidt, C; Kleinberg, DL; Ganguly, M
1977 ;7(5):423-427, Clinical endocrinology
— id: 29562, year: 1977, vol: 7, page: 423, stat: Journal Article,

EFFECT OF PROLACTIN ON ALPHA-LACTALBUMIN IN NORMAL HUMAN AND PRIMATE BREAST
Kleinberg, DL; Todd, J; Niemann, W
1976 ;24(3):A273-A273, Clinical research
— id: 28753, year: 1976, vol: 24, page: A273, stat: Journal Article,

Human alpha-lactalbumin: measurement in serum and in breast cancer organ cultures by radioimmunoassay
Kleinberg, D L
1975 Oct;190(4211):276-278, Science
— id: 163391, year: 1975, vol: 190, page: 276, stat: Journal Article,

HUMAN ALPHA-LACTALBUMIN - MEASUREMENT IN SERUM AND IN BREAST-CANCER ORGAN-CULTURES BY RADIOIMMUNOASSAY
KLEINBERG, DL
1975 ;190(4211):276-278, Science
— id: 98733, year: 1975, vol: 190, page: 276, stat: Journal Article,

HUMAN ALPHA-LACTALBUMIN BY RADIOIMMUNOASSAY - SERUM AND ORGAN- CULTURE MEASUREMENTS
Kleinberg, DL; Todd, J
1975 ;23(3):A238-A238, Clinical research
— id: 28536, year: 1975, vol: 23, page: A238, stat: Journal Article,

The sesamoid index. An aid in the diagnosis of acromegaly
Kleinberg, D L; Young, I S; Kupperman, H S
1966 May;64(5):1075-1078, Annals of internal medicine
— id: 125510, year: 1966, vol: 64, page: 1075, stat: Journal Article,