Yong H Kim, M.D.

Multi-level spondylolysis
Hersh D.S.; Kim Y.H.; Razi A.
2011 ;69(4):339-343, Bulletin of the NYU Hospital for Joint Diseases
The incidence of isthmic spondylolysis is approximately 3% to 6% in the general population. Spondylolytic defects involving multiple vertebral levels, on the other hand, are extremely rare. Only a handful of reports have examined the outcomes of surgical treatment of multi-level spondylolysis. Here, we present one case of bilateral pars defects at L3, L4, and L5. The patient, a 46-year-old female, presented with lower back pain radiating into the left lower extremity. Radiographs and CT scans of the lumbar spine revealed bilateral pars defects at L3-L5. The patient underwent lumbar discectomy and interbody fusion of L4-S1 as well as direct repair of the pars defect at L3. There were no postoperative complications, and by seven months the patient had improved clinically. While previous reports describe the use of either direct repair or fusion in the treatment of spondylolysis, we are unaware of reports describing the use of both techniques at adjacent levels
— id: 148748, year: 2011, vol: 69, page: 339, stat: Journal Article,

Clinical end points and response criteria in mycosis fungoides and Sezary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer
Olsen, Elise A; Whittaker, Sean; Kim, Youn H; Duvic, Madeleine; Prince, H Miles; Lessin, Stuart R; Wood, Gary S; Willemze, Rein; Demierre, Marie-France; Pimpinelli, Nicola; Bernengo, Maria Grazia; Ortiz-Romero, Pablo L; Bagot, Martine; Estrach, Teresa; Guitart, Joan; Knobler, Robert; Sanches, Jose Antonio; Iwatsuki, Keiji; Sugaya, Makoto; Dummer, Reinhard; Pittelkow, Mark; Hoppe, Richard; Parker, Sareeta; Geskin, Larisa; Pinter-Brown, Lauren; Girardi, Michael; Burg, Gunter; Ranki, Annamari; Vermeer, Maartan; Horwitz, Steven; Heald, Peter; Rosen, Steve; Cerroni, Lorenzo; Dreno, Brigette; Vonderheid, Eric C
2011 Jun 20;29(18):2598-2607, Journal of clinical oncology
Mycosis fungoides (MF) and Sezary syndrome (SS), the major forms of cutaneous T-cell lymphoma, have unique characteristics that distinguish them from other types of non-Hodgkin's lymphomas. Clinical trials in MF/SS have suffered from a lack of standardization in evaluation, staging, assessment, end points, and response criteria. Recently defined criteria for the diagnosis of early MF, guidelines for initial evaluation, and revised staging and classification criteria for MF and SS now offer the potential for uniform staging of patients enrolled in clinical trials for MF/SS. This article presents consensus recommendations for the general conduct of clinical trials of patients with MF/SS as well as methods for standardized assessment of potential disease manifestations in skin, lymph nodes, blood, and visceral organs, and definition of end points and response criteria. These guidelines should facilitate collaboration among investigators and collation of data from sponsor-generated or investigator-initiated clinical trials involving patients with MF or SS
— id: 136470, year: 2011, vol: 29, page: 2598, stat: Journal Article,

The Incidence of Potential Candidates for Total Disc Replacement among Lumbar and Cervical Fusion Patient Populations
Quirno, Martin; Goldstein, Jeffrey A; Bendo, John A; Kim, Yong; Spivak, Jeffrey M
2011 Dec;5(4):213-219, Asian spine journal
STUDY DESIGN: Retrospective chart review. PURPOSE: To evaluate the incidence of potential total disc replacement (TDR) candidates among cervical and lumbar fusion patient populations using strict Food and Drug Administration (FDA) criteria and with relative exclusion criteria removed. OVERVIEW OF LITERATURE: Recent studies suggest that the potential percentage of patients that are candidates for TDR ranges from 0-5% in lumbar fusions and 43% in cervical fusions. METHODS: We performed a retrospective chart review of 280 consecutive patients who had lumbar (n = 174) and cervical (n = 106) fusion or TDR performed by one of four independent adult orthopaedic spine surgeons. Charts were screened for investigational device exemption (IDE) inclusion/exclusion criteria and later reanalyzed excluding relative exclusion criteria, such as history of chronic medical illness, twolevel disease (cervical cases), and history of prior fusion surgery in the anatomic region. RESULTS: Of the 174 lumbar surgeries, 10 were TDR with Prodisc-L and 164 were lumbar fusions. The most common TDR exclusion criteria were lytic spondylolisthesis or spinal stenosis (47.7% of patients) and more than 2 level degenerative disc disease (37.9%). 14.9% had no IDE exclusion criteria and would be considered candidates for TDR. After excluding the relative lumbar exclusion criteria, this percentage increased to 25.8%. Of the 106 cervical cases, 3 had a TDR with Prodisc-C and 103 had a cervical fusion. Twenty eight percent had no IDE exclusion criteria and would be considered candidates for cervical TDR. CONCLUSIONS: A larger percentage of cervical fusion candidates are potential candidates for TDR (28%) than lumbar fusion candidates (14.9%) based on the strict IDE criteria
— id: 147694, year: 2011, vol: 5, page: 213, stat: Journal Article,

Minimizing blood loss in major spinal surgery: a review of the current literature
Kim, Yong H; Li, Robert
2010 Dec;39(12):E130-E134, American journal of orthopedics (Belle Mead, NJ)
— id: 134923, year: 2010, vol: 39, page: E130, stat: Journal Article,

Sacral osteomyelitis after robotically assisted laparoscopic sacral colpopexy
Nosseir, Sandy B; Kim, Yong H; Lind, Lawrence R; Winkler, Harvey A
2010 Aug;116(2 Pt 2):513-515, Obstetrics & gynecology
BACKGROUND:: Osteomyelitis associated with using synthetic mesh for laparoscopic sacral colpopexy is rare. CASE:: We present a patient who developed Staphylococcus sacral osteomyelitis after sacral colpopexy with synthetic mesh and titanium tack fixation to the sacral promontory in the absence of mesh erosion or fistula formation. The patient presented with low back pain 6 weeks postoperatively. Magnetic resonance imaging, bone aspirate, and culture confirmed sacral osteomyelitis and discitis 10 weeks after surgery. The patient underwent 8 weeks of outpatient antibiotic treatment. Six months after surgery, serial laboratory values have demonstrated excellent response to antibiotic treatment, and the patient has clinically improved without the need for mesh removal. CONCLUSION:: We recommend a high index of suspicion for osteomyelitis in patients who present with back pain after sacral colpopexy. Osteomyelitis can occur as a complication of laparoscopic, robotic sacral colpopexy using mesh in the absence of abscess or fistula formation
— id: 111365, year: 2010, vol: 116, page: 513, stat: Journal Article,

Pendrin modulates ENaC function by changing luminal HCO3-
Pech, Vladimir; Pham, Truyen D; Hong, Seongun; Weinstein, Alan M; Spencer, Kathryn B; Duke, Billy Jean; Walp, Eric; Kim, Young Hee; Sutliff, Roy L; Bao, Hui-Fang; Eaton, Douglas C; Wall, Susan M
2010 Nov;21(11):1928-1941, Journal of the American Society of Nephrology
The epithelial Na(+) channel, ENaC, and the Cl(-)/HCO(3)(-) exchanger, pendrin, mediate NaCl absorption within the cortical collecting duct and the connecting tubule. Although pendrin and ENaC localize to different cell types, ENaC subunit abundance and activity are lower in aldosterone-treated pendrin-null mice relative to wild-type mice. Because pendrin mediates HCO(3)(-) secretion, we asked if increasing distal delivery of HCO(3)(-) through a pendrin-independent mechanism 'rescues' ENaC function in pendrin-null mice. We gave aldosterone and NaHCO(3) to increase pendrin-dependent HCO(3)(-) secretion within the connecting tubule and cortical collecting duct, or gave aldosterone and NaHCO(3) plus acetazolamide to increase luminal HCO(3)(-) concentration, [HCO(3)(-)], independent of pendrin. Following treatment with aldosterone and NaHCO(3), pendrin-null mice had lower urinary pH and [HCO(3)(-)] as well as lower renal ENaC abundance and function than wild-type mice. With the addition of acetazolamide, however, acid-base balance as well as ENaC subunit abundance and function was similar in pendrin-null and wild-type mice. We explored whether [HCO(3)(-)] directly alters ENaC abundance and function in cultured mouse principal cells (mpkCCD). Amiloride-sensitive current and ENaC abundance rose with increased [HCO(3)(-)] on the apical or the basolateral side, independent of the substituting anion. However, ENaC was more sensitive to changes in [HCO(3)(-)] on the basolateral side of the monolayer. Moreover, increasing [HCO(3)(-)] on the apical and basolateral side of Xenopus kidney cells increased both ENaC channel density and channel activity. We conclude that pendrin modulates ENaC abundance and function, at least in part by increasing luminal [HCO(3)(-)] and/or pH
— id: 133826, year: 2010, vol: 21, page: 1928, stat: Journal Article,

Challenges to setting spinal cord stimulator parameters during intraoperative testing: factors affecting coverage of low back and leg pain
Gordon, Assaf T; Zou, Sheng Ping; Kim, Yong; Gharibo, Christopher
2007 Apr;10(2):133-141, Neuromodulation
Objective. Spinal cord stimulator (SCS) parameter settings have been well studied; however, the goal of this exploratory study was to examine the SCS parameters used during intra-operative stimulation (IOS) at trial lead placement. Methods. In this retrospective study, we report the IOS parameter settings for 22 patients who underwent thoracic SCS lead trial for treatment of refractory low back and/or leg pain. Results. Paresthesia coverage was shown to differ depending upon the pain syndrome and the region involved (back and/or leg, p = 0.03). Certain stimulation parameters were demonstrated to be linked, including pulse width with rate (p = 0.04) and bipolar activation distance with amplitude (p < 0.01). Important variations in field configuration practice patterns also emerged. Conclusions. Larger prospective studies are required to confirm and extend the current results. The ultimate goal for this report is to establish a foundation for future studies to create an evidence-based standardized algorithm for IOS to enhance the success rate of SCS trial screening
— id: 146259, year: 2007, vol: 10, page: 133, stat: Journal Article,

Osteoporotic vertebral compression fractures: a review of current surgical management techniques
Shen, Michael; Kim, Yong
2007 May;36(5):241-248, American journal of orthopedics (Belle Mead, NJ)
Of the estimated 1.5 million osteoporosis-related fragility fractures that occur each year in the United States, vertebral compression fractures (VCFs) are the most common. It is estimated that approximately 20% to 25% of people who sustain a VCF have symptoms severe enough to seek medical attention. However, nonoperative outpatient management for VCFs is often successful in only 75% to 80% of cases. In this article, we provide a comprehensive review of VCFs and of the surgical alternatives for VCF management, including indications for surgical intervention, overview of surgical techniques, clinical results, complications, and areas of future investigation
— id: 73117, year: 2007, vol: 36, page: 241, stat: Journal Article,

Vertebroplasty and kyphoplasty: treatment techniques for managing osteoporotic vertebral compression fractures
Shen, Michael S; Kim, Yong H
2006 ;64(3-4):106-113, Bulletin of the NYU Hospital for Joint Diseases
— id: 72404, year: 2006, vol: 64, page: 106, stat: Journal Article,

The role of fusion surgery for low back pain
Kim YH; Hochschuler SH
2002 ;19(4):152-163, Journal of musculoskeletal medicine
— id: 74784, year: 2002, vol: 19, page: 152, stat: Journal Article,

The role of intraoperative Gram stain in revision total joint arthroplasty
Della Valle CJ; Scher DM; Kim YH; Oxley CM; Desai P; Zuckerman JD; Di Cesare PE
1999 Jun;14(4):500-504, Journal of arthroplasty
The ability to identify intraoperatively patients with an infected prosthesis at the time of a revision procedure assists the surgeon in selecting appropriate management. The results of 413 intraoperative Gram stains were compared with the results of operative cultures, permanent histology, and the surgeon's intraoperative assessment to determine the ability of Gram stains to identify periprosthetic infection. Gram staining correctly identified the presence of infection in 10 of the 68 cases that met study criteria for infection (sensitivity of 14.7%). Four false-positive Gram stains were encountered. Intraoperative Gram stains do not have adequate sensitivity to be helpful in identifying periprosthetic infection and should not be performed on a routine basis. They may be helpful, however, in cases in which gross purulence is encountered to assist in the selection of initial antibiotic therapy. The use of intraoperative Gram staining alone is inadequate for ruling out infection at the time of revision total joint arthroplasty
— id: 6165, year: 1999, vol: 14, page: 500, stat: Journal Article,

Patella fractures. Evaluation and treatment
Koval KJ; Kim YH
1997 Spring;10(2):101-108, American journal of knee surgery
— id: 7184, year: 1997, vol: 10, page: 101, stat: Journal Article,

Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension
Dworkin, L D; Levin, R I; Benstein, J A; Parker, M; Ullian, M E; Kim, Y; Feiner, H D
1990 Oct;259(4 Pt 2):F598-F604, American journal of physiology
Male Munich-Wistar rats underwent right nephrectomy and were given weekly injections of deoxycorticosterone acetate (DOCA) and 1% saline (salt) to drink. Two studies were performed. In the first, rats given enalapril (ENP) were compared with controls. In the second, rats ingested either standard chow or chow to which the calcium-entry blocker nifedipine (NIF) had been added. Six to eight weeks after nephrectomy, both control DOCA-salt rats and those given ENP had severe hypertension and significant proteinuria. Rats given NIF excreted less protein, and glomerular lesions were not observed in this group. The effects of NIF on several parameters that have been associated with glomerular injury were examined. Micropuncture studies revealed that glomerular capillary pressure was increased in DOCA-salt rats and was not reduced by NIF. Platelet aggregation was also similar in NIF-treated and control rats. Morphometric studies revealed a tendency toward lower glomerular volume of NIF-treated rats; however, kidney weight and glomerular capillary radius were unaffected by therapy. Thus NIF, but not ENP, prevents DOCA-salt rats from developing hypertension and glomerular injury. This effect does not depend on reduction in glomerular pressure or inhibition of platelet aggregation
— id: 74783, year: 1990, vol: 259, page: F598, stat: Journal Article,