Biosketch / Results /

Karen Holopigian-Cahill, Ph.D.

Professor;
Departments of Ophthalmology (Resident Train ) and Administration

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Research Summary

Our research involves the electrophysiological examination of the sites and mechanisms of rod and cone function in patients with retinal diseases, including diabetes, open-angle glaucoma, AIDS, and retinitis pigmentosa, an inherited, progressive degenerative disease. Our research has a twofold purpose: 1) to provide prognostic information to ophthalmologists and patients and 2) to provide information about the mechanisms and pathogenesis of the disease. Currently, we use the full-field, flash electroretinogram (ERG) to measure the electrical response of the eye to brief, high intensity flashes. We then use a model of receptor activity to derive fits to these data and estimate the parameters of Rmax (maximum response amplitude) and log S (sensitivity). The results on patients with diabetes indicated that, for the majority of the patients, Rmax was normal, but log S was reduced, consistent with deficits in photoreceptor transduction. Analysis of b-wave and oscillatory potential parameters provided evidence for rod and cone postreceptoral abnormalities not accounted for by receptoral changes. Presently, we are applying this technique to the visual processing of patients with open-angle glaucoma to determine whether recent anatomical reports of outer retinal losses in these patients can be verified using electrophysiological techniques.

Research Interests

Electrophysiological Analysis of Rod/Cone Activity in Retinal Disease

Research Keywords

cone, electroretinogram, retinal disease, rod

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

A primer on common statistical errors in clinical ophthalmology
Holopigian, Karen; Bach, Michael
2010 Dec;121(3):215-222, Documenta ophthalmologica
— id: 114196, year: 2010, vol: 121, page: 215, stat: Journal Article,

Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens
Greenstein, Vivienne C; Chiosi, Flavia; Baker, Paul; Seiple, William; Holopigian, Karen; Braunstein, Richard E; Sparrow, Janet R
2007 Apr;33(4):667-672, Journal of cateract & refractive surgery
— id: 71300, year: 2007, vol: 33, page: 667, stat: Journal Article,

Eccentricity-dependent changes in local onset and offset responses in patients with progressive cone dystrophy
Holopigian, K; Wynn, P; Seiple, W; Carr, R E; Hood, D C
2007 Aug;47(17):2297-2304, Vision research
— id: 73870, year: 2007, vol: 47, page: 2297, stat: Journal Article,

A prospective study of rod and cone function in patients with dominantly inherited, progressive cone dystrophy
Holopigian, K; Greenstein, VC; Seiple, W; Gallardo, JM; Noble, KG; Carr, RE
2005 ;46(Suppl S):4086-4086, Investigative ophthalmology & visual science. IOVS
— id: 56199, year: 2005, vol: 46, page: 4086, stat: Journal Article,

Multifocal visual evoked potentials to cone specific stimuli in patients with retinitis pigmentosa
Holopigian, K; Shuwairi, S M; Greenstein, V C; Winn, B J; Zhang, X; Carr, R E; Hood, D C
2005 Nov;45(25-26):3244-3252, Vision research
— id: 61418, year: 2005, vol: 45, page: 3244, stat: Journal Article,

The multifocal visual evoked potential: an objective measure of visual fields?
Seiple, William; Holopigian, Karen; Clemens, Colleen; Greenstein, Vivienne C; Hood, Donald C
2005 Apr;45(9):1155-1163, Vision research
— id: 51786, year: 2005, vol: 45, page: 1155, stat: Journal Article,

Reliability of multifocal electroretinograms and Humphrey visual field thresholds in patients with retinitis pigmentosa
Clemens, CJ; Seiple, W; Holopigian, K; Carr, RE
2004 APR ;45(9):U577-U577, Investigative ophthalmology & visual science. IOVS
— id: 48934, year: 2004, vol: 45, page: U577, stat: Journal Article,

Atypical multifocal ERG responses in patients with diseases affecting the photoreceptors
Greenstein, V C; Holopigian, K; Seiple, W; Carr, R E; Hood, D C
2004 Nov;44(25):2867-2874, Vision research
— id: 92140, year: 2004, vol: 44, page: 2867, stat: Journal Article,

An examination of local ON- and OFF-System responses in patients with progressive cone dystrophy using long duration LED stimulation
Holopigian, K; Wynn, P; Clemens, CJ; Seiple, W; Carr, RE; Hood, DC
2004 APR ;45(9):U586-U586, Investigative ophthalmology & visual science. IOVS
— id: 48935, year: 2004, vol: 45, page: U586, stat: Journal Article,

Rod and cone photoreceptor function in patients with cone dystrophy
Holopigian, Karen; Greenstein, Vivienne C; Seiple, William; Hood, Donald C; Carr, Ronald E
2004 Jan;45(1):275-281, Investigative ophthalmology & visual science. IOVS
— id: 42630, year: 2004, vol: 45, page: 275, stat: Journal Article,

Test-retest reliability of the multifocal electroretinogram and humphrey visual fields in patients with retinitis pigmentosa
Seiple, William; Clemens, Colleen J; Greenstein, Vivienne C; Carr, Ronald E; Holopigian, Karen
2004 Nov;109(3):255-272, Documenta ophthalmologica
— id: 55997, year: 2004, vol: 109, page: 255, stat: Journal Article,

Multidimensional visual field maps: Relationships among local psychophysical and local electrophysiological measures
Seiple, William; Holopigian, Karen; Szlyk, Janet P; Wu, Carolyn
2004 May;41(3A):359-372, Journal of rehabilitation research & development
— id: 46898, year: 2004, vol: 41, page: 359, stat: Journal Article,

A comparison of multifocal and full-field photopic electroretinograms in patients with retinitis pigmentosa
Wynn, P; Holopigian, K; Carr, RE; Hood, DC
2004 APR ;45(9):U576-U576, Investigative ophthalmology & visual science. IOVS
— id: 48933, year: 2004, vol: 45, page: U576, stat: Journal Article,

M-versus P-function: Relationship to visual field loss in patients with open angle glaucoma
Badr, AA; Zemon, VM; Greenstein, VC; Clemens, CJ; Holopigian, K; Seiple, W
2003 MAY ;44(3):U5-U5, Investigative ophthalmology & visual science. IOVS
— id: 55412, year: 2003, vol: 44, page: U5, stat: Journal Article,

Local ON and OFF system responses in patients with progressive cone dystrophy
Holopigian, K; Seiple, W; Clemens, CJ; Rozenbaum, I; Carr, RE
2003 MAY ;44(3):U105-U105, Investigative ophthalmology & visual science. IOVS
— id: 55417, year: 2003, vol: 44, page: U105, stat: Journal Article,

Electrophysiology
Holopigian, Karen; Hood, Donald C
2003 Jun;16(2):237-251, Ophthalmology clinics of North America
— id: 93711, year: 2003, vol: 16, page: 237, stat: Journal Article,

The retinotopic distribution of localized attention assessed using the multifocal visual evoked potential
Kirzhner, M; Nam, JN; Clemens, CJ; Holopigian, K
2003 MAY ;44(19):U447-U447, Investigative ophthalmology & visual science. IOVS
— id: 55466, year: 2003, vol: 44, page: U447, stat: Journal Article,

The effect of variably tinted spectacle lenses on visual performance in cataract subjects
Naidu, Srilata; Lee, Jason E; Holopigian, Karen; Seiple, William H; Greenstein, Vivienne C; Stenson, Susan M
2003 Jan;29(1):17-20, Eye & contact lens
— id: 39215, year: 2003, vol: 29, page: 17, stat: Journal Article,

Reliability of perimetry: Measures of acuity, contrast sensitivity, and luminance detection
Nam, JN; Kirzhner, M; Clemens, CJ; Holopigian, K; Seiple, W
2003 MAY ;44(19):U671-U671, Investigative ophthalmology & visual science. IOVS
— id: 55467, year: 2003, vol: 44, page: U671, stat: Journal Article,

Multifocal electroretinography as a function of age: the importance of normative values for older adults
Seiple, William; Vajaranant, Thasarat S; Szlyk, Janet P; Clemens, Colleen; Holopigian, Karen; Paliga, Jennifer; Badawi, David; Carr, Ronald E
2003 Apr;44(4):1783-1792, Investigative ophthalmology & visual science. IOVS
— id: 39262, year: 2003, vol: 44, page: 1783, stat: Journal Article,

Test-retest reliability of psychophysical and electrophysiological perimetric measures in patients with retinitis pigmentosa
Clemens, CJ; Kirzhner, M; Holopigian, K; Seiple, W; Greenstein, VC; Carr, RE
2002 MAY ;43(3):U254-U254, Investigative ophthalmology & visual science. IOVS
— id: 55483, year: 2002, vol: 43, page: U254, stat: Journal Article,

Local cone and rod system function in progressive cone dystrophy
Holopigian, Karen; Seiple, William; Greenstein, Vivienne C; Hood, Donald C; Carr, Ronald E
2002 Jul;43(7):2364-2373, Investigative ophthalmology & visual science. IOVS
— id: 39621, year: 2002, vol: 43, page: 2364, stat: Journal Article,

Effect of variable tinted spectacle lenses on visual performance in control subjects
Lee, Jason E; Stein, Jonathan J; Prevor, Meredith B; Seiple, William H; Holopigian, Karen; Greenstein, Vivienne C; Stenson, Susan M
2002 Apr;28(2):80-82, CLAO journal (Contact Lens Association of Ophthalmologists)
— id: 37709, year: 2002, vol: 28, page: 80, stat: Journal Article,

Relationships among luminance, acuity, contrast, and electrophysiological perimetry in patients with retinitis pigmentosa
Seiple, WH; Clemens, C; Holopigian, K; Greenstein, V; Carr, R
2002 MAY ;43(3):U254-U254, Investigative ophthalmology & visual science. IOVS
— id: 55482, year: 2002, vol: 43, page: U254, stat: Journal Article,

The spatial distribution of selective attention assessed using the multifocal visual evoked potential
Seiple, William; Clemens, Colleen; Greenstein, Vivienne C; Holopigian, Karen; Zhang, Xian
2002 Jun;42(12):1513-1521, Vision research
— id: 39622, year: 2002, vol: 42, page: 1513, stat: Journal Article,

A method for comparing psychophysical and multifocal electroretinographic increment thresholds
Seiple, William; Greenstein, Vivienne C; Holopigian, Karen; Carr, Ronald E; Hood, Donald C
2002 Jan;42(2):257-269, Vision research
— id: 39725, year: 2002, vol: 42, page: 257, stat: Journal Article,

Multifocal visual evoked potentials to cone specific stimuli in patients with retinitis pigmentosa (RP)
Shuwairi, SM; Holopigian, K; Greenstein, VC; Zhang, X; Hood, DC
2002 MAY ;43(3):U271-U271, Investigative ophthalmology & visual science. IOVS
— id: 55484, year: 2002, vol: 43, page: U271, stat: Journal Article,

Localized attention assessed using the multifocal visual evoked potential
Clemens, CJ; Seiple, W; Holopigian, K; Greenstein, VC; Zhang, X
2001 MAR 15 ;42(4):S408-S408, Investigative ophthalmology & visual science. IOVS
— id: 54975, year: 2001, vol: 42, page: S408, stat: Journal Article,

An examination of visual evoked potential increment thresholds as a function of retinal eccentricity
Donsoff, I; Holopigian, K; Rubbani, S; Seiple, W
2001 MAR 15 ;42(4):S789-S789, Investigative ophthalmology & visual science. IOVS
— id: 54990, year: 2001, vol: 42, page: S789, stat: Journal Article,

Local cone and rod system function in patients with retinitis pigmentosa
Holopigian K; Seiple W; Greenstein VC; Hood DC; Carr RE
2001 Mar;42(3):779-788, Investigative ophthalmology & visual science. IOVS
— id: 26783, year: 2001, vol: 42, page: 779, stat: Journal Article,

Sites of cone and rod system loss in patients with progressive cone dystrophy
Holopigian, K; Greenstein, VC; Wu, C; Seiple, W; Hood, DC; Carr, RE
2001 MAR 15 ;42(4):S71-S71, Investigative ophthalmology & visual science. IOVS
— id: 54969, year: 2001, vol: 42, page: S71, stat: Journal Article,

Variable tinted spectacle lenses: a comparison of aesthetics and visual preference
Huang L; Seiple W; Park RI; Greenstein VC; Holopigian K; Naidu SS; Stenson SM
2001 Jul;27(3):121-124, CLAO journal (Contact Lens Association of Ophthalmologists)
— id: 26629, year: 2001, vol: 27, page: 121, stat: Journal Article,

Duration thresholds for target detection and identification in the peripheral visual field
Seiple W; Holopigian K; Shnayder Y; Szlyk JP
2001 Mar;78(3):169-176, Optometry & vision science
— id: 20698, year: 2001, vol: 78, page: 169, stat: Journal Article,

Retinal function in diabetic macular edema after focal laser photocoagulation
Greenstein VC; Chen H; Hood DC; Holopigian K; Seiple W; Carr RE
2000 Oct;41(11):3655-3664, Investigative ophthalmology & visual science. IOVS
— id: 39554, year: 2000, vol: 41, page: 3655, stat: Journal Article,

The nature and extent of retinal dysfunction associated with diabetic macular edema
Greenstein VC; Holopigian K; Hood DC; Seiple W; Carr RE
2000 Oct;41(11):3643-3654, Investigative ophthalmology & visual science. IOVS
— id: 39555, year: 2000, vol: 41, page: 3643, stat: Journal Article,

Electrophysiologic assessment of photoreceptor function in patients with primary open-angle glaucoma
Holopigian K; Greenstein VC; Seiple W; Hood DC; Ritch R
2000 Apr;9(2):163-168, Journal of glaucoma
— id: 11735, year: 2000, vol: 9, page: 163, stat: Journal Article,

Are the differences between threshold visual fields and multifocal ERGs due to adaptation level?
Holopigian, K; Seiple, W; Greenstein, VC; Hood, DC; Carr, RE
2000 MAR 15 ;41(4):S892-S892, Investigative ophthalmology & visual science. IOVS
— id: 54624, year: 2000, vol: 41, page: S892, stat: Journal Article,

An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG
Hood, D C; Greenstein, V C; Holopigian, K; Bauer, R; Firoz, B; Liebmann, J M; Odel, J G; Ritch, R
2000 May;41(6):1570-1579, Investigative ophthalmology & visual science. IOVS
— id: 93712, year: 2000, vol: 41, page: 1570, stat: Journal Article,

A comparison of psychophysical and multifocal electroretinographic increment thresholds as a function of retinal location
Seiple, W; Holopigian, K; Greenstein, VC; Hood, DC
2000 MAR 15 ;41(4):S496-S496, Investigative ophthalmology & visual science. IOVS
— id: 54616, year: 2000, vol: 41, page: S496, stat: Journal Article,

Functional peripheral visual performance in patients with RP
Holopigian, K; Seiple, W; Wu, C; Carr, RE
1999 May 9-14;40(4):S718-S718, Investigative ophthalmology & visual science. IOVS
— id: 34141, year: 1999, vol: 40, page: S718, stat: Journal Article,

Identifying inner retinal contributions to the human multifocal ERG
Hood, D C; Greenstein, V; Frishman, L; Holopigian, K; Viswanathan, S; Seiple, W; Ahmed, J; Robson, J G
1999 Jun;39(13):2285-2291, Vision research
— id: 93713, year: 1999, vol: 39, page: 2285, stat: Journal Article,

Retinotopic distribution of the temporal aspects of letter identification
Seiple, W; Wu, C; Holopigian, K; Szlyk, J; Shnayder, Y; Chen, H
1999 May 9-14;40(4):S34-S34, Investigative ophthalmology & visual science. IOVS
— id: 34142, year: 1999, vol: 40, page: S34, stat: Journal Article,

Multifocal rod electroretinograms
Hood DC; Wladis EJ; Shady S; Holopigian K; Li J; Seiple W
1998 Jun;39(7):1152-1162, Investigative ophthalmology & visual science. IOVS
— id: 57168, year: 1998, vol: 39, page: 1152, stat: Journal Article,

Assessment of local retinal function in patients with retinitis pigmentosa using the multi-focal ERG technique
Hood, D C; Holopigian, K; Greenstein, V; Seiple, W; Li, J; Sutter, E E; Carr, R E
1998 Jan;38(1):163-179, Vision research
— id: 92135, year: 1998, vol: 38, page: 163, stat: Journal Article,

Multi-focal ERGs and visual fields in diabetic patients with macular edema
Greenstein, VC; Holopigian, K; Seiple, W; Kahanowicz, R; Katz, A
1997 MAR 15 ;38(4):3548-3548, Investigative ophthalmology & visual science. IOVS
— id: 53242, year: 1997, vol: 38, page: 3548, stat: Journal Article,

Evidence for photoreceptor changes in patients with diabetic retinopathy
Holopigian K; Greenstein VC; Seiple W; Hood DC; Carr RE
1997 Oct;38(11):2355-2365, Investigative ophthalmology & visual science. IOVS
— id: 12264, year: 1997, vol: 38, page: 2355, stat: Journal Article,

Relative effects of aging and age-related macular degeneration on peripheral visual function
Holopigian K; Seiple W; Greenstein V; Kim D; Carr RE
1997 Mar;74(3):152-159, Optometry & vision science
— id: 56952, year: 1997, vol: 74, page: 152, stat: Journal Article,

A comparison of the components of the multifocal and full-field ERGs
Hood, D C; Seiple, W; Holopigian, K; Greenstein, V
1997 May-Jun;14(3):533-544, Visual neuroscience
— id: 93714, year: 1997, vol: 14, page: 533, stat: Journal Article,

Rod multi-focal ERGs
Hood, DC; Wladis, EJ; Shady, S; Holopigian, K; Li, J; Seiple, W
1997 MAR 15 ;38(4):4121-4121, Investigative ophthalmology & visual science. IOVS
— id: 53243, year: 1997, vol: 38, page: 4121, stat: Journal Article,

Electroretinographic and psychophysical findings during early and late stages of human immunodeficiency virus infection and cytomegalovirus retinitis
Latkany PA; Holopigian K; Lorenzo-Latkany M; Seiple W
1997 Mar;104(3):445-453, Ophthalmology
— id: 12368, year: 1997, vol: 104, page: 445, stat: Journal Article,

Rates of change differ among measures of visual function in patients with retinitis pigmentosa
Holopigian K; Greenstein V; Seiple W; Carr RE
1996 Mar;103(3):398-405, Ophthalmology
— id: 7005, year: 1996, vol: 103, page: 398, stat: Journal Article,

Assessment of receptoral and post-receptoral changes in primary open-angle glaucoma
Holopigian, K; Pollack, A; Greenstein, VC; Seiple, W; Hood, DC; Ritch, R
1996 FEB 15 ;37(3):2343-2343, Investigative ophthalmology & visual science. IOVS
— id: 53023, year: 1996, vol: 37, page: 2343, stat: Journal Article,

Do the delays in the cone ERG from patients with RP indicate global retinal damage?
Hood, DC; Holopigian, K; Greenstein, VC; Seiple, W; Carr, RE; Sutter, EE
1996 FEB 15 ;37(3):1558-1558, Investigative ophthalmology & visual science. IOVS
— id: 53022, year: 1996, vol: 37, page: 1558, stat: Journal Article,

Outer-retina locus of increased flicker sensitivity of the peripheral retina
Seiple W; Holopigian K
1996 Mar;13(3):658-666, Journal of the Optical Society of America. Pt. A. Optics & image science
— id: 7046, year: 1996, vol: 13, page: 658, stat: Journal Article,

Age-related functional field losses are not eccentricity dependent
Seiple W; Szlyk JP; Yang S; Holopigian K
1996 Jun;36(12):1859-1866, Vision research
— id: 56990, year: 1996, vol: 36, page: 1859, stat: Journal Article,

ROD AND CONE PHOTORECEPTOR ANALYSIS IN PATIENTS WITH DIABETIC-RETINOPATHY
HOLOPIGIAN, K; KELLY, R; GREENSTEIN, VC; SEIPLE, W; HOOD, DC
1995 MAR 15 ;36(4):S480-S480, Investigative ophthalmology & visual science. IOVS
— id: 87337, year: 1995, vol: 36, page: S480, stat: Journal Article,

The effects of random element loss on letter identification: implications for visual acuity loss in patients with retinitis pigmentosa
Seiple W; Holopigian K; Szlyk JP; Greenstein VC
1995 Jul;35(14):2057-2066, Vision research
— id: 56847, year: 1995, vol: 35, page: 2057, stat: Journal Article,

Comparison of visual evoked potential and psychophysical contrast sensitivity
Seiple W; Kupersmith MJ; Holopigian K
1995 ;80(1-4):173-180, International journal of neuroscience
— id: 12835, year: 1995, vol: 80, page: 173, stat: Journal Article,

The effects of dopamine blockade on the human flash electroretinogram
Holopigian K; Clewner L; Seiple W; Kupersmith MJ
1994 ;86(1):1-10, Documenta ophthalmologica
— id: 57469, year: 1994, vol: 86, page: 1, stat: Journal Article,

DECREASED RETINAL FUNCTION IN HIV AIDS PATIENTS WITH AND WITHOUT CMV RETINITIS
LATKANY, P; FROST, K; HOLOPIGIAN, K; PAK, SM; LORENZO, M; SEIPLE, W
1994 MAR 15 ;35(4):1310-1310, Investigative ophthalmology & visual science. IOVS
— id: 52541, year: 1994, vol: 35, page: 1310, stat: Journal Article,

VISUAL-LOSS CAUSED BY RETINAL CHOROIDAL LESIONS ASSOCIATED WITH CAVERNOUS SINUS REGION AV SHUNTS
PAK, S; KUPERSMITH, MJ; HOLOPIGIAN, K; SEIPLE, W
1994 MAR 15 ;35(4):1374-1374, Investigative ophthalmology & visual science. IOVS
— id: 52543, year: 1994, vol: 35, page: 1374, stat: Journal Article,

The 'OFF' response of the human electroretinogram does not contribute to the brief flash 'b-wave'
Seiple W; Holopigian K
1994 Jul-Aug;11(4):667-673, Visual neuroscience
— id: 6746, year: 1994, vol: 11, page: 667, stat: Journal Article,

Visual evoked potentials following abrupt contrast changes
Xin D; Seiple W; Holopigian K; Kupersmith MJ
1994 Nov;34(21):2813-2821, Vision research
— id: 56731, year: 1994, vol: 34, page: 2813, stat: Journal Article,

INCREMENT THRESHOLD CURVES - THE EFFECTS OF PERIODIC AND APERIODIC STIMULI
YANG, S; HU, HP; GREENSTEIN, VC; HOLOPIGIAN, K; SEIPLE, W
1994 MAR 15 ;35(4):1835-1835, Investigative ophthalmology & visual science. IOVS
— id: 52556, year: 1994, vol: 35, page: 1835, stat: Journal Article,

PROSPECTIVE-STUDY OF CENTRAL VISUAL FUNCTION IN RETINITIS-PIGMENTOSA
CARR, R; HOLOPIGIAN, K; GREENSTEIN, V; KY, W; HALEVY, D; SEIPLE, W
1993 MAR 15 ;34(4):1369-1369, Investigative ophthalmology & visual science. IOVS
— id: 54327, year: 1993, vol: 34, page: 1369, stat: Journal Article,

The effects of acetazolamide on visual function in retinitis pigmentosa
Greenstein VC; Holopigian K; Siderides E; Seiple W; Carr RE
1993 Jan;34(1):269-273, Investigative ophthalmology & visual science. IOVS
— id: 13297, year: 1993, vol: 34, page: 269, stat: Journal Article,

ELECTROPHYSIOLOGICAL EVIDENCE FOR OUTER RETINAL DEFICITS IN PRIMARY OPEN ANGLE GLAUCOMA
HOLOPIGIAN, K; SEIPLE, W; GREENSTEIN, VC
1993 MAR 15 ;34(4):1269-1269, Investigative ophthalmology & visual science. IOVS
— id: 54326, year: 1993, vol: 34, page: 1269, stat: Journal Article,

Electro-oculogram changes in patients with ocular hypertension and primary open-angle glaucoma
Mehaffey L; Holopigian K; Seiple W
1993 ;83(2):103-110, Documenta ophthalmologica
— id: 57458, year: 1993, vol: 83, page: 103, stat: Journal Article,

Comparison of P100 and P300 cortical potentials in spatial frequency discrimination
Mehaffey, L 3rd; Seiple, W; Holopigian, K
1993 ;85(2):173-183, Documenta ophthalmologica
— id: 93715, year: 1993, vol: 85, page: 173, stat: Journal Article,

Sites of cone system sensitivity loss in retinitis pigmentosa
Seiple WH; Holopigian K; Greenstein VC; Hood DC
1993 Aug;34(9):2638-2645, Investigative ophthalmology & visual science. IOVS
— id: 56588, year: 1993, vol: 34, page: 2638, stat: Journal Article,

INDEPENDENCE OF SAMPLING DENSITY AND VISUAL RECOGNITION
SEIPLE, W; HOLOPIGIAN, K; SZLYK, JP
1993 MAR 15 ;34(4):777-777, Investigative ophthalmology & visual science. IOVS
— id: 54317, year: 1993, vol: 34, page: 777, stat: Journal Article,

SUPRATHRESHOLD VEP EVIDENCE OF MERIDIONAL AMBLYOPIA
XIN, D; KUPERSMITH, MJ; SEIPLE, W; HOLOPIGIAN, K
1993 MAR 15 ;34(4):864-864, Investigative ophthalmology & visual science. IOVS
— id: 54318, year: 1993, vol: 34, page: 864, stat: Journal Article,

THE EFFECTS OF ACETAZOLAMIDE ON CENTRAL AND PERIPHERAL VISUAL FUNCTION IN RETINITIS-PIGMENTOSA
CARR, R; GREENSTEIN, V; HOLOPIGIAN, K; SEIPLE, W
1992 MAR 15 ;33(4):1072-1072, Investigative ophthalmology & visual science. IOVS
— id: 52049, year: 1992, vol: 33, page: 1072, stat: Journal Article,

A comparison of photopic and scotopic electroretinographic changes in early diabetic retinopathy
Holopigian K; Seiple W; Lorenzo M; Carr R
1992 Sep;33(10):2773-2780, Investigative ophthalmology & visual science. IOVS
— id: 57456, year: 1992, vol: 33, page: 2773, stat: Journal Article,

ANALYSIS OF ROD SYSTEM ACTIVITY IN DIABETES-MELLITUS
HOLOPIGIAN, K; GREENSTEIN, V; SEIPLE, W; WEINER, M; HOOD, D
1992 MAR 15 ;33(4):1365-1365, Investigative ophthalmology & visual science. IOVS
— id: 52056, year: 1992, vol: 33, page: 1365, stat: Journal Article,

ELECTROPHYSIOLOGICAL AND PSYCHOPHYSICAL ASSESSMENT OF AGE-RELATED MACULAR DEGENERATION
KIM, D; DUBOVY, S; HOLOPIGIAN, K; GREENSTEIN, V; SEIPLE, W; CARR, R
1992 MAR 15 ;33(4):1231-1231, Investigative ophthalmology & visual science. IOVS
— id: 52053, year: 1992, vol: 33, page: 1231, stat: Journal Article,

OPTIC ATROPHY FAILS TO ALTER THE FLASH ELECTRORETINOGRAM
KUPERSMITH MJ; GUPTA K; SEIPLE WH; HOLOPIGIAN K
1992 MAY ;7(3):247-250, Clinical vision sciences
— id: 130408, year: 1992, vol: 7, page: 247, stat: Journal Article,

Maculopathy caused by intra-arterially administered cisplatin and intravenously administered carmustine
Kupersmith MJ; Seiple WH; Holopigian K; Noble K; Hiesiger E; Warren F
1992 Apr 15;113(4):435-438, American journal of ophthalmology
— id: 13630, year: 1992, vol: 113, page: 435, stat: Journal Article,

Temporal frequency dependent adaptation at the level of the outer retina in humans
Seiple W; Holopigian K; Greenstein V; Hood DC
1992 Nov;32(11):2043-2048, Vision research
— id: 57457, year: 1992, vol: 32, page: 2043, stat: Journal Article,

ERG FLICKER SENSITIVITY AS A FUNCTION OF RETINAL ECCENTRICITY AND ADA
SEIPLE, W; HOLOPIGIAN, K; LORENZO, M
1992 MAR 15 ;33(4):837-837, Investigative ophthalmology & visual science. IOVS
— id: 52045, year: 1992, vol: 33, page: 837, stat: Journal Article,

VEP AMPLITUDE AND PHASE-CHANGES FOLLOWING DISCRETE CONTRAST STEPS
XIN, DY; KUPERSMITH, M; HOLOPIGIAN, K; SEIPLE, W
1992 MAR 15 ;33(4):833-833, Investigative ophthalmology & visual science. IOVS
— id: 52044, year: 1992, vol: 33, page: 833, stat: Journal Article,

DOPAMINE BLOCKADE HAS NO EFFECT ON THE HUMAN FLASH ERG
CLEWNER, L; HOLOPIGIAN, K; SEIPLE, W; ANGRIST, B; KUPERSMITH, M
1991 MAR 15 ;32(4):1229-1229, Investigative ophthalmology & visual science. IOVS
— id: 51686, year: 1991, vol: 32, page: 1229, stat: Journal Article,

SEPARATION OF ON AND OFF RESPONSES IN THE HUMAN ERG
HOLOPIGIAN, K; SEIPLE, W; HAN, S; CINCIRIPINI, G; CARR, R
1991 MAR 15 ;32(4):1229-1229, Investigative ophthalmology & visual science. IOVS
— id: 51685, year: 1991, vol: 32, page: 1229, stat: Journal Article,

VEP THRESHOLD AND SUPRATHRESHOLD DEFICITS IN AMBLYOPIA
Holopigian, K; Seiple, W; Kupersmith, M
1991 Apr;6(2):109-117, Clinical vision sciences
— id: 32189, year: 1991, vol: 6, page: 109, stat: Journal Article,

MACULOPATHY CAUSED BY CHEMOTHERAPY
KUPERSMITH, M; SEIPLE, W; HOLOPIGIAN, K; NOBLE, K; HIESIGER, E; WARREN, F
1991 MAR 15 ;32(4):690-690, Investigative ophthalmology & visual science. IOVS
— id: 51673, year: 1991, vol: 32, page: 690, stat: Journal Article,

NONLINEARITIES IN THE FOCAL ELECTRORETINOGRAM
SEIPLE, W; HOLOPIGIAN, K
1991 JAN ;6(6):413-421, Clinical vision sciences
— id: 52118, year: 1991, vol: 6, page: 413, stat: Journal Article,

Electrophysiological and psychophysical flicker sensitivity in patients with primary open-angle glaucoma and ocular hypertension
Holopigian, K; Seiple, W; Mayron, C; Koty, R; Lorenzo, M
1990 Sep;31(9):1863-1868, Investigative ophthalmology & visual science. IOVS
— id: 93716, year: 1990, vol: 31, page: 1863, stat: Journal Article,

Clinical suppression and binocular rivalry suppression: the effects of stimulus strength on the depth of suppression
Holopigian, K
1989 ;29(10):1325-1333, Vision research
— id: 93717, year: 1989, vol: 29, page: 1325, stat: Journal Article,

An examination of VEP response phase
Seiple W; Holopigian K
1989 Dec;73(6):520-531, Electroencephalography & clinical neurophysiology
— id: 10425, year: 1989, vol: 73, page: 520, stat: Journal Article,

Variability of the pattern electroretinogram
Holopigian K; Snow J; Seiple W; Siegel I
1988 Sep;70(1):103-115, Documenta ophthalmologica
— id: 10972, year: 1988, vol: 70, page: 103, stat: Journal Article,

Clinical suppression and amblyopia
Holopigian, K; Blake, R; Greenwald, M J
1988 Mar;29(3):444-451, Investigative ophthalmology & visual science. IOVS
— id: 93718, year: 1988, vol: 29, page: 444, stat: Journal Article,

Changes in the focal electroretinogram with retinal eccentricity
Seiple W; Greenstein V; Holopigian K; Carr R
1988 Sep;70(1):29-36, Documenta ophthalmologica
— id: 10971, year: 1988, vol: 70, page: 29, stat: Journal Article,

Spatial-frequency discrimination in cats
Blake, R; Holopigian, K; Wilson, H R
1986 Sep;3(9):1443-1449, Journal of the Optical Society of America. Pt. A. Optics & image science
— id: 93719, year: 1986, vol: 3, page: 1443, stat: Journal Article,

Selective losses in binocular vision in anisometropic amblyopes
Holopigian, K; Blake, R; Greenwald, M J
1986 ;26(4):621-630, Vision research
— id: 93720, year: 1986, vol: 26, page: 621, stat: Journal Article,

Orientation selectivity in cats and humans assessed by masking
Blake, R; Holopigian, K
1985 ;25(10):1459-1467, Vision research
— id: 93722, year: 1985, vol: 25, page: 1459, stat: Journal Article,

Another visual illusion involving orientation
Blake, R; Holopigian, K; Jauch, M
1985 ;25(10):1469-1476, Vision research
— id: 93721, year: 1985, vol: 25, page: 1469, stat: Journal Article,

Abnormal spatial frequency channels in esotropic cats
Holopigian, K; Blake, R
1984 ;24(7):677-687, Vision research
— id: 93723, year: 1984, vol: 24, page: 677, stat: Journal Article,

Spatial vision in strabismic cats
Holopigian, K; Blake, R
1983 Jul;50(1):287-296, Journal of neurophysiology
— id: 93724, year: 1983, vol: 50, page: 287, stat: Journal Article,