Krystyna Frenkel

Biosketch / Results /

Krystyna Frenkel, Ph.D.

Research Professor;
Departments of Environmental Medicine and Pathology

Contact Info

Address
550 First Avenue
PHL-802 Floor 8 Room 802C
Public Health Lab
New York , NY 10016

212-263-6610
212-263-6649
Krystyna.Frenkel@nyumc.org


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Education

1959-1964 — Warsaw University School of Chemistry, Poland, Graduate Education
1971-1974 — New York University GSAS, Graduate Education
1974-1976 — Columbia University Institute of Cancer Research, New York, NY, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Increased endogenous oxidative levels correlate to increased iron in melanocytes
Pelle, E.; Huang, X.; Zhang, Q.; Pernodet, N.; Yarosh, D. B.; Frenkel, K.
2014 MAY;134 1 1:S124-S124, Journal of investigative dermatology
— id: 997182, year: 2014, vol: 134 1 1, page: S124, stat: Journal Article,

Propolis and its active component, Caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action
Omene, C; Kalac, M; Wu, J; Marchi, E; Frenkel, K; O'Connor, O A
2013 2013;5(10):334-342, Journal of cancer science & therapy
— id: 712982, year: 2013, vol: 5, page: 334, stat: Journal Article,

Menopause increases the iron storage protein ferritin in skin
Pelle, Edward; Jian, Jinlong; Zhang, Qi; Muizzuddin, Neelam; Yang, Qing; Dai, Jisen; Maes, Daniel; Pernodet, Nadine; Yarosh, Daniel B; Frenkel, Krystyna; Huang, Xi
2013 May-Jun;64(3):175-179, Journal of cosmetic science
— id: 438832, year: 2013, vol: 64, page: 175, stat: Journal Article,

Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells
Omene CO; Wu J; Frenkel K
2012 May 3;:1279-1288 #, Investigational new drugs
— id: 146298, year: 2012, vol: , page: 1279, stat: Journal Article,

Protection against UVB-induced oxidative stress in human skin cells and skin models by methionine sulfoxide reductase A
Pelle, Edward; Maes, Daniel; Huang, Xi; Frenkel, Krystyna; Pernodet, Nadine; Yarosh, Daniel B; Zhang, Qi
2012 Nov-Dec;63(6):359-364, Journal of cosmetic science
— id: 211452, year: 2012, vol: 63, page: 359, stat: Journal Article,

Biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: Markers of immune response?
Siegel EM; Patel N; Lu B; Lee JH; Nyitray AG; Craft NE; Frenkel K; Villa LL; Franco EL; Giuliano AR
2012 Aug 19;:219-228, International journal of cancer
— id: 146299, year: 2012, vol: , page: 219, stat: Journal Article,

Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation
Wu, Jing; Sowinska, Anna; Huang, Xi; Klein, Catherine B; Pelle, Edward; Frenkel, Krystyna
2012 Oct;25(5):927-937, Biometals
— id: 177140, year: 2012, vol: 25, page: 927, stat: Journal Article,

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer
Wu, Jing; Omene, Coral; Karkoszka, Jerzy; Bosland, Maarten; Eckard, Jonathan; Klein, Catherine B; Frenkel, Krystyna
2011 Sep 1;308(1):43-53, Cancer letters
— id: 134448, year: 2011, vol: 308, page: 43, stat: Journal Article,

Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis
Eckard, Jonathan; Dai, Jisen; Wu, Jing; Jian, Jinlong; Yang, Qing; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2010 ;10:28-28, Cancer cell international
— id: 114147, year: 2010, vol: 10, page: 28, stat: Journal Article,

Morphologic transformation of human breast epithelial cells MCF-10A: dependence on an oxidative microenvironment and estrogen/epidermal growth factor receptors
Yusuf, Rita; Frenkel, Krystyna
2010 ;10:30-30, Cancer cell international
— id: 112553, year: 2010, vol: 10, page: 30, stat: Journal Article,

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, David E; Strong, Randy; Sharp, Zelton Dave; Nelson, James F; Astle, Clinton M; Flurkey, Kevin; Nadon, Nancy L; Wilkinson, J Erby; Frenkel, Krystyna; Carter, Christy S; Pahor, Marco; Javors, Martin A; Fernandez, Elizabeth; Miller, Richard A
2009 Jul 16;460(7253):392-395, Nature
— id: 146300, year: 2009, vol: 460, page: 392, stat: Journal Article,

Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status
Dai, Jisen; Jian, Jinlong; Bosland, Maarten; Frenkel, Krystyna; Bernhardt, Guenther; Huang, Xi
2008 Apr;17(2):172-179, Breast
— id: 80282, year: 2008, vol: 17, page: 172, stat: Journal Article,

Induction and prevention of carcinogenesis in rat skin exposed to space radiation
Burns, Fredric J; Tang, Moon-shong; Frenkel, Krystyna; Nadas, Arthur; Wu, Feng; Uddin, Ahmed; Zhang, Ronghe
2007 Jun;46(2):195-199, Radiation & environmental biophysics
— id: 159218, year: 2007, vol: 46, page: 195, stat: Journal Article,

Antimutagenic effects of caffeic acid phenethyl ester (CAPE) in human breast cancer cells and relationship to gene expression
Lyon, JL; Leszczynska, JM; Wu, J; Frenkel, K; Klein, CB
2007 AUG ;48(7):613-613, Environmental & molecular mutagenesis
— id: 74191, year: 2007, vol: 48, page: 613, stat: Journal Article,

Reliability of serum assays of iron status in postmenopausal women
Zeleniuch-Jacquotte, Anne; Zhang, Qi; Dai, Jisen; Shore, Roy E; Arslan, Alan A; Koenig, Karen L; Karkoszka, Jerzy; Afanasyeva, Yelena; Frenkel, Krystyna; Toniolo, Paolo; Huang, Xi
2007 May;17(5):354-358, Annals of epidemiology
— id: 73252, year: 2007, vol: 17, page: 354, stat: Journal Article,

Altered iron homeostasis involvement in arsenite-mediated cell transformation
Wu, Jing; Eckard, Jonathan; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2006 Feb 1;40(3):444-452, Free radical biology & medicine
— id: 64134, year: 2006, vol: 40, page: 444, stat: Journal Article,

Mapping and prediction of coal workers' pneumoconiosis with bioavailable iron content in the bituminous coals
Huang, Xi; Li, Weihong; Attfield, Michael D; Nadas, Arthur; Frenkel, Krystyna; Finkelman, Robert B
2005 Aug;113(8):964-968, Environmental health perspectives
— id: 62597, year: 2005, vol: 113, page: 964, stat: Journal Article,

OGG1 activity assessed by a sensitive HPLC technique
Pelle, E; Maes, D; Frenkel, K; Mammone, T
2005 APR ;124(4):A137-A137, Journal of investigative dermatology
— id: 55690, year: 2005, vol: 124, page: A137, stat: Journal Article,

Keratinocytes act as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes
Pelle, Edward; Mammone, Thomas; Maes, Daniel; Frenkel, Krystyna
2005 Apr;124(4):793-797, Journal of investigative dermatology
— id: 71125, year: 2005, vol: 124, page: 793, stat: Journal Article,

Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells
Yang, Chengfeng; Wu, Jing; Zhang, Ronghe; Zhang, Ping; Eckard, Jonathan; Yusuf, Rita; Huang, Xi; Rossman, Toby G; Frenkel, Krystyna
2005 Sep 15;213(1-2):81-96, Toxicology
— id: 58743, year: 2005, vol: 213, page: 81, stat: Journal Article,

Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
Dai, Jisen; Huang, Chuanshu; Wu, Jing; Yang, Chengfeng; Frenkel, Krystyna; Huang, Xi
2004 Oct 15;203(1-3):199-209, Toxicology
— id: 47848, year: 2004, vol: 203, page: 199, stat: Journal Article,

Randomized, placebo-controlled pilot trial of the effects of alpha-tocopherol supplementation on levels of autoantibodies against 5-hydroxymethyl-2-deoxyuridine in melanoma patients
Mahabir, Somdat; Frenkel, Krystyna; Brady, Mary Sue; Coit, Daniel; Leibes, Leonard; Karkoszka, Jerzy; Berwick, Marianne
2004 Feb;14(1):49-56, Melanoma research
— id: 71126, year: 2004, vol: 14, page: 49, stat: Journal Article,

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women
Ali, M Aktar; Akhmedkhanov, Arslan; Zeleniuch-Jaquotte, Anne; Toniolo, Paolo; Frenkel, Krystyna; Huang, Xi
2003 ;27(2):116-121, Cancer detection & prevention
— id: 34537, year: 2003, vol: 27, page: 116, stat: Journal Article,

Influence of postmenopausal hormone replacement therapy on an estrogen metabolite biomarker of risk for breast cancer
Alvarez-Vasquez, R B; Axelrod, D; Frenkel, K; Newman, M C; Sepkovic, D W; Bradlow, H L; Zumoff, B
2003 Jun;35(6):358-361, Hormone & metabolic research
— id: 38127, year: 2003, vol: 35, page: 358, stat: Journal Article,

Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats
Choudhury, Sujata; Zhang, Ronghe; Frenkel, Krystyna; Kawamori, Toshihiko; Chung, Fung-Lung; Roy, Rabindra
2003 Nov 15;63(22):7704-7707, Cancer research
— id: 72098, year: 2003, vol: 63, page: 7704, stat: Journal Article,

Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger
Pelle, Edward; Huang, Xi; Mammone, Thomas; Marenus, Kenneth; Maes, Daniel; Frenkel, Krystyna
2003 Jul;121(1):177-183, Journal of investigative dermatology
— id: 38128, year: 2003, vol: 121, page: 177, stat: Journal Article,

Antibodies against 5-hydroxymethyl-2'-deoxyuridine are associated with lifestyle factors and GSTM1 genotype: a report from the Malmo Diet and Cancer cohort
Wallstrom, Peter; Frenkel, Krystyna; Wirfalt, Elisabet; Gullberg, Bo; Karkoszka, Jerzy; Seidegard, Janeric; Janzon, Lars; Berglund, Goran
2003 May;12(5):444-451, Cancer epidemiology biomarkers & prevention
— id: 38129, year: 2003, vol: 12, page: 444, stat: Journal Article,

Oxidized DNA bases in breast cancer
Desai, Mehul; Frenkel, Krystyna
[S.l.] : Ft. Belvoir Defense Technical Information Center, 2002,
— id: 1278, year: 2002, vol: , page: , stat: ,

Chronic inflammation and cancer - The Shacter/Weitzman article reviewed
Frenkel, K
2002 Feb;16(2):230-231, Oncology
— id: 27531, year: 2002, vol: 16, page: 230, stat: Journal Article,

Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells
Huang, Xi; Dai, Jisen; Fournier, Jeanine; Ali, Aktar M; Zhang, Qi; Frenkel, Krystyna
2002 Jan 1;32(1):84-92, Free radical biology & medicine
— id: 34035, year: 2002, vol: 32, page: 84, stat: Journal Article,

Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses
Li, Xiaolu; Eckard, Jonathan; Shah, Rajendra; Malluck, Chenlu; Frenkel, Krystyna
2002 Jan 15;62(2):417-423, Cancer research
— id: 34034, year: 2002, vol: 62, page: 417, stat: Journal Article,

Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis
Yang, Chengfeng; Frenkel, Krystyna
2002 ;21(4):331-342, Journal of environmental pathology, toxicology & oncology
— id: 34033, year: 2002, vol: 21, page: 331, stat: Journal Article,

Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans
Cooney RV; Maskarinec G; Franke AA; Okinaka L; Karkoszka J; Wilkens LR; Frenkel K
2001 Aug 15;31(4):460-468, Free radical biology & medicine
— id: 34037, year: 2001, vol: 31, page: 460, stat: Journal Article,

Oxidized DNA bases in breast cancer
Desai, Mehul K; Frenkel, Krystyna
[Alexandria VA] : Ft. Belvoir Defense Technical Information Center, 2001,
— id: 1673, year: 2001, vol: , page: , stat: ,

Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses
Huang X; Powell J; Mooney LA; Li C; Frenkel K
2001 Dec 1;31(11):1341-1351, Free radical biology & medicine
— id: 34036, year: 2001, vol: 31, page: 1341, stat: Journal Article,

Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers
Mooney LA; Perera FP; Van Bennekum AM; Blaner WS; Karkoszka J; Covey L; Hsu Y; Cooper TB; Frenkel K
2001 Jun;10(6):641-648, Cancer epidemiology biomarkers & prevention
— id: 34038, year: 2001, vol: 10, page: 641, stat: Journal Article,

Oxidative stress-mediated transformation of MCF-10 human mammary cells: Roles of hydrocortisone (HC), 17beta-estradiol (E2), and 7,12-dimethylbenz[a]anthracene (DMBA)
Yusuf, R; Frenkel, K
2001 AUG ;31(5):S142-S142, Free radical biology & medicine
— id: 54794, year: 2001, vol: 31, page: S142, stat: Journal Article,

Estrogens as endogenous genotoxic agents--DNA adducts and mutations
Cavalieri E; Frenkel K; Liehr JG; Rogan E; Roy D
2000 ;10(27):75-93, Journal of the National Cancer Institute. Monographs
— id: 34039, year: 2000, vol: 10, page: 75, stat: Journal Article,

Bioavailable or potentially bioavailable iron as a biomarker of cancer risk
Huang, X; Zhang, Q; Ali, A; Dai, J S; Frenkel, K
2000 Nov 16-20;29(Supplement 1):S16-S16, Free radical biology & medicine
— id: 15768, year: 2000, vol: 29, page: S16, stat: Journal Article,

The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution
Khan AU; Kovacic D; Kolbanovskiy A; Desai M; Frenkel K; Geacintov NE
2000 Mar 28;97(7):2984-2989, Proceedings of the National Academy of Sciences of the United States of America
— id: 34041, year: 2000, vol: 97, page: 2984, stat: Journal Article,

Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU)
Hu JJ; Chi CX; Frenkel K; Smith BN; Henfelt JJ; Berwick M; Mahabir S; D'Agostino RB Jr
1999 Aug;8(8):693-698, Cancer epidemiology biomarkers & prevention
— id: 34040, year: 1999, vol: 8, page: 693, stat: Journal Article,

Serum autoantibodies recognizing 5-hydroxymethyl-2'-deoxyuridine, an oxidized DNA base, as biomarkers of cancer risk in women
Frenkel K; Karkoszka J; Glassman T; Dubin N; Toniolo P; Taioli E; Mooney LA; Kato I
1998 Jan;7(1):49-57, Cancer epidemiology biomarkers & prevention
— id: 8027, year: 1998, vol: 7, page: 49, stat: Journal Article,

Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil
Kato I; Vogelman JH; Dilman V; Karkoszka J; Frenkel K; Durr NP; Orentreich N; Toniolo P
1998 Sep;14(6):621-626, European journal of epidemiology
— id: 7626, year: 1998, vol: 14, page: 621, stat: Journal Article,

Molecular markers of exposure to cadmium and nickel among alkaline battery workers
Taioli, E; Frenkel, K; Tagesson, C; Baranski, B; Ganguly, S; Karkoszka, J; Toniolo, P; Cohen, B; Garte, S
1998 MAR-APR ;3(2):129-140, Biomarkers
— id: 53516, year: 1998, vol: 3, page: 129, stat: Journal Article,

Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis
Huang MT; Ma W; Yen P; Xie JG; Han J; Frenkel K; Grunberger D; Conney AH
1997 Jan;18(1):83-88, Carcinogenesis
— id: 34042, year: 1997, vol: 18, page: 83, stat: Journal Article,

Inhibitory effects of curcumin on tumorigenesis in mice
Huang MT; Newmark HL; Frenkel K
1997 ;27:26-34, Journal of cellular biochemistry. Supplement
— id: 7608, year: 1997, vol: 27, page: 26, stat: Journal Article,

Low serum thiol levels predict shorter times-to-death among HIV-infected injecting drug users
Marmor M; Alcabes P; Titus S; Frenkel K; Krasinski K; Penn A; Pero RW
1997 Sep;11(11):1389-1393, AIDS
— id: 7212, year: 1997, vol: 11, page: 1389, stat: Journal Article,

Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells
Huang MT; Ma W; Yen P; Xie JG; Han J; Frenkel K; Grunberger D; Conney AH
1996 Apr;17(4):761-765, Carcinogenesis
— id: 34043, year: 1996, vol: 17, page: 761, stat: Journal Article,

Human promyelocytic leukemia cells (HL-60): a new model to study the effects of chemopreventive agents on H2O2 production
Bhimani RS; Zhong Z; Schleifer E; Troll W; Frenkel K
1995 ;19(3):292-298, Cancer detection & prevention
— id: 6577, year: 1995, vol: 19, page: 292, stat: Journal Article,

7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo
Frenkel K; Wei L; Wei H
1995 Sep;19(3):373-380, Free radical biology & medicine
— id: 7924, year: 1995, vol: 19, page: 373, stat: Journal Article,

Immunotoxicity of low level cadmium exposure in fish: an alternative animal model for immunotoxicological studies
Zelikoff JT; Bowser D; Squibb KS; Frenkel K
1995 Jul;45(3):235-248, Journal of toxicology & environmental health
— id: 6880, year: 1995, vol: 45, page: 235, stat: Journal Article,

Effects of in vitro nickel exposure on the macrophage-mediated immune functions of rainbow trout (Oncorhynchus mykiss)
Bowser DH; Frenkel K; Zelikoff JT
1994 Mar;52(3):367-373, Bulletin of environmental contamination & toxicology
— id: 7877, year: 1994, vol: 52, page: 367, stat: Journal Article,

Occupational exposures to Cd, Ni, and Cr modulate titers of antioxidized DNA base autoantibodies
Frenkel K; Karkoszka J; Cohen B; Baranski B; Jakubowski M; Cosma G; Taioli E; Toniolo P
1994 Sep;102 Suppl 3:221-225, Environmental health perspectives
— id: 6621, year: 1994, vol: 102 Suppl 3, page: 221, stat: Journal Article,

The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis
Huang X; Zhuang Z; Frenkel K; Klein CB; Costa M
1994 Sep;102 Suppl 3:281-284, Environmental health perspectives
— id: 6647, year: 1994, vol: 102 Suppl 3, page: 281, stat: Journal Article,

Application of reliability models to studies of biomarker validation
Taioli E; Kinney P; Zhitkovich A; Fulton H; Voitkun V; Cosma G; Frenkel K; Toniolo P; Garte S; Costa M
1994 Mar;102(3):306-309, Environmental health perspectives
— id: 10381, year: 1994, vol: 102, page: 306, stat: Journal Article,

PREVENTION OF CANCER BY AGENTS THAT SUPPRESS PRODUCTION OF OXIDANTS
TROLL, W; LIM, JS; FRENKEL, K
1994 APR 18 ;547(3):116-121, ACS symposium series
— id: 98445, year: 1994, vol: 547, page: 116, stat: Journal Article,

Inhibition of oxidative stress in HeLa cells by chemopreventive agents
Bhimani RS; Troll W; Grunberger D; Frenkel K
1993 Oct 1;53(19):4528-4533, Cancer research
— id: 6324, year: 1993, vol: 53, page: 4528, stat: Journal Article,

Biological markers of macrophage activation: applications for fish phagocytes
Enane NA; Frenkel K; O'Connor JM; Squibb KS; Zelikoff JT
1993 Sep;80(1):68-72, Immunology
— id: 6365, year: 1993, vol: 80, page: 68, stat: Journal Article,

Recognition of oxidized DNA bases by sera of patients with inflammatory diseases
Frenkel K; Karkoszka J; Kim E; Taioli E
1993 May;14(5):483-494, Free radical biology & medicine
— id: 13180, year: 1993, vol: 14, page: 483, stat: Journal Article,

Methods used for analyses of "environmentally" damaged nucleic acids
Frenkel K; Klein CB
1993 Aug 25;618(1-2):289-314, Journal of chromatography
— id: 6373, year: 1993, vol: 618, page: 289, stat: Journal Article,

Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester
Frenkel K; Wei H; Bhimani R; Ye J; Zadunaisky JA; Huang MT; Ferraro T; Conney AH; Grunberger D
1993 Mar 15;53(6):1255-1261, Cancer research
— id: 13216, year: 1993, vol: 53, page: 1255, stat: Journal Article,

METHODS USED FOR ANALYSES OF ENVIRONMENTALLY DAMAGED NUCLEIC-ACIDS
FRENKEL, K; KLEIN, CB
1993 AUG 25 ;618(1-2):289-314, Journal of chromatography. Pt. B. Biomedical applications
— id: 52242, year: 1993, vol: 618, page: 289, stat: Journal Article,

Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence
Huang X; Frenkel K; Klein CB; Costa M
1993 May;120(1):29-36, Toxicology & applied pharmacology
— id: 10384, year: 1993, vol: 120, page: 29, stat: Journal Article,

The Malmo biomarker programme
Pero RW; Berglund G; Christie NT; Cosma GN; Frenkel K; Garte SJ; Janzon L; Olsson A; Seidegard J; Smulson ME; et al.
1993 Jan;233(1):69-74, Journal of internal medicine
— id: 34044, year: 1993, vol: 233, page: 69, stat: Journal Article,

Antibody titers to an oxidized thymidine moiety are altered by systemic pharmacotherapy and by ultraviolet B phototherapy
Sasson M; Stiller MJ; Shupack JL; Khasak D; Karkoszka J; Frenkel K
1993 ;285(4):227-229, Archives of dermatological research
— id: 13323, year: 1993, vol: 285, page: 227, stat: Journal Article,

Mechanisms of action of new antitumor promoters
Suganuma M; Yoshizawa S; Yatsunami J; Nishiwaki S; Furuya H; Okabe S; Nishiwaki-Matsushima R; Frenkel K; Troll W; Verma AK; et al.
1993 ;61(4):317-323, Basic life sciences
— id: 34046, year: 1993, vol: 61, page: 317, stat: Journal Article,

Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters
Wei H; Frenkel K
1993 Jun;14(6):1195-1201, Carcinogenesis
— id: 13139, year: 1993, vol: 14, page: 1195, stat: Journal Article,

Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein
Wei H; Wei L; Frenkel K; Bowen R; Barnes S
1993 ;20(1):1-12, Nutrition & cancer
— id: 34045, year: 1993, vol: 20, page: 1, stat: Journal Article,

Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage
Wei L; Wei H; Frenkel K
1993 May;14(5):841-847, Carcinogenesis
— id: 13179, year: 1993, vol: 14, page: 841, stat: Journal Article,

Carcinogen-mediated oxidant formation and oxidative DNA damage
Frenkel K
1992 ;53(1):127-166, Pharmacology & therapeutics
— id: 13735, year: 1992, vol: 53, page: 127, stat: Journal Article,

Enhanced antibody titers to an oxidized DNA base in inflammatory and neoplastic diseases
Frenkel K; Khasak D; Karkoszka J; Shupack J; Stiller M
1992 Dec;1(5):242-247, Experimental dermatology
— id: 6622, year: 1992, vol: 1, page: 242, stat: Journal Article,

SARCOPHYTOL-A AND ITS ANALOGS - CANCER PREVENTIVE ACTIVITY
FUJIKI, H; SUGANUMA, M; TAKAGI, K; NISHIWAKI, S; YOSHIZAWA, S; OKABE, S; YATSUNAMI, J; FRENKEL, K; TROLL, W; MARSHALL, JA; TIUS, MA
1992 JAN ;507(1):380-387, ACS symposium series
— id: 54398, year: 1992, vol: 507, page: 380, stat: Journal Article,

Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils
Lim JS; Frenkel K; Troll W
1992 Sep 15;52(18):4969-4972, Cancer research
— id: 13440, year: 1992, vol: 52, page: 4969, stat: Journal Article,

Mechanism of mutagenicity by 5-hydroperoxymethyl-2'-deoxyuridine, an intermediate product of ionizing radiation, in bacteria. HPMdU bacterial mutagenicity and oxidation of DNA bases
Patel U; Bhimani R; Frenkel K
1992 Oct;283(2):145-156, Mutation research
— id: 13426, year: 1992, vol: 283, page: 145, stat: Journal Article,

Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion
Wei H; Frenkel K
1992 Apr 15;52(8):2298-2303, Cancer research
— id: 13629, year: 1992, vol: 52, page: 2298, stat: Journal Article,

Lens opacification and H2O2 elevation induced by a tumor promoter
Ye JJ; Frenkel K; Zadunaisky JA
1992 ;9(1):37-48, Lens & eye toxicity research
— id: 13745, year: 1992, vol: 9, page: 37, stat: Journal Article,

PENTA-O-GALLOYL-BETA-D-GLUCOSE AND (-)-EPIGALLOCATECHIN GALLATE - CANCER PREVENTIVE AGENTS
YOSHIZAWA, S; HORIUCHI, T; SUGANUMA, M; NISHIWAKI, S; YATSUNAMI, J; OKABE, S; OKUDA, T; MUTO, Y; FRENKEL, K; TROLL, W; FUJIKI, H
1992 JAN ;507(1):316-325, ACS symposium series
— id: 54397, year: 1992, vol: 507, page: 316, stat: Journal Article,

Hydrogen peroxide formation by cells treated with a tumor promoter
Frenkel K; Gleichauf C
1991 ;12-13 Pt 2:783-794, Free radical research communications
— id: 14157, year: 1991, vol: 12-13 Pt 2, page: 783, stat: Journal Article,

Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo
Frenkel K; Zhong ZJ; Wei HC; Karkoszka J; Patel U; Rashid K; Georgescu M; Solomon JJ
1991 Jul;196(1):126-136, Analytical biochemistry
— id: 13980, year: 1991, vol: 196, page: 126, stat: Journal Article,

The role of oxidative processes in metal carcinogenesis
Klein CB; Frenkel K; Costa M
1991 Nov-Dec;4(6):592-604, Chemical research in toxicology
— id: 13852, year: 1991, vol: 4, page: 592, stat: Journal Article,

In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin
Wei H; Frenkel K
1991 Aug 15;51(16):4443-4449, Cancer research
— id: 13939, year: 1991, vol: 51, page: 4443, stat: Journal Article,

Development of fish peritoneal macrophages as a model for higher vertebrates in immunotoxicological studies. I. Characterization of trout macrophage morphological, functional, and biochemical properties
Zelikoff JT; Enane NA; Bowser D; Squibb KS; Frenkel K
1991 Apr;16(3):576-589, Fundamental & applied toxicology
— id: 14093, year: 1991, vol: 16, page: 576, stat: Journal Article,

Suppression of tumor promotion by inhibitors of poly(ADP)ribose formation
Troll W; Garte S; Frenkel K
1990 ;52(23):225-232, Basic life sciences
— id: 34047, year: 1990, vol: 52, page: 225, stat: Journal Article,

Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes
Zhong ZJ; Troll W; Koenig KL; Frenkel K
1990 Dec 1;50(23):7564-7570, Cancer research
— id: 14252, year: 1990, vol: 50, page: 7564, stat: Journal Article,

Oxidation of DNA bases by tumor promoter-activated processes
Frenkel K
1989 May;81:45-54, Environmental health perspectives
— id: 10649, year: 1989, vol: 81, page: 45, stat: Journal Article,

Decomposition of nucleoside hydroperoxide by metals and metalloproteins
Frenkel K; Tofigh S
1989 Jul-Sep;21:351-357, Biological trace element research
— id: 10579, year: 1989, vol: 21, page: 351, stat: Journal Article,

Effect of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA
Tofigh S; Frenkel K
1989 ;7(2):131-143, Free radical biology & medicine
— id: 10843, year: 1989, vol: 7, page: 131, stat: Journal Article,

Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes
Frenkel K; Chrzan K
1987 Mar;8(3):455-460, Carcinogenesis
— id: 34051, year: 1987, vol: 8, page: 455, stat: Journal Article,

Chymotrypsin-specific protease inhibitors decrease H2O2 formation by activated human polymorphonuclear leukocytes
Frenkel K; Chrzan K; Ryan CA; Wiesner R; Troll W
1987 Sep;8(9):1207-1212, Carcinogenesis
— id: 34048, year: 1987, vol: 8, page: 1207, stat: Journal Article,

Definitive characterization of human thymine glycol N-glycosylase activity
Higgins SA; Frenkel K; Cummings A; Teebor GW
1987 Mar 24;26(6):1683-1688, Biochemistry
— id: 34050, year: 1987, vol: 26, page: 1683, stat: Journal Article,

Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation
Shirname-More L; Rossman TG; Troll W; Teebor GW; Frenkel K
1987 Jun;178(2):177-186, Mutation research
— id: 34049, year: 1987, vol: 178, page: 177, stat: Journal Article,

Quantitative measurement of the diastereoisomers of cis thymidine glycol in gamma-irradiated DNA
Teebor G; Cummings A; Frenkel K; Shaw A; Voituriez L; Cadet J
1987 ;2(4-6):303-309, Free radical research communications
— id: 11406, year: 1987, vol: 2, page: 303, stat: Journal Article,

Protease inhibitors: possible preventive agents of various types of cancer and their mechanisms of action
Troll W; Frenkel K; Wiesner R
1987 ;239:297-315, Progress in clinical & biological research
— id: 11422, year: 1987, vol: 239, page: 297, stat: Journal Article,

Anticarcinogenic action of protease inhibitors
Troll W; Wiesner R; Frenkel K
1987 ;49:265-283, Advances in cancer research
— id: 11419, year: 1987, vol: 49, page: 265, stat: Journal Article,

Copper ions and hydrogen peroxide form hypochlorite from NaCl thereby mimicking myeloperoxidase
Frenkel K; Blum F; Troll W
1986 ;30(3):181-193, Journal of cellular biochemistry
— id: 34054, year: 1986, vol: 30, page: 181, stat: Journal Article,

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes
Frenkel K; Chrzan K; Troll W; Teebor GW; Steinberg JJ
1986 Nov;46(11):5533-5540, Cancer research
— id: 34052, year: 1986, vol: 46, page: 5533, stat: Journal Article,

Protease inhibitors: their role as modifiers of carcinogenic processes
Troll W; Frenkel K; Wiesner R
1986 ;199(11):153-165, Advances in experimental medicine & biology
— id: 34053, year: 1986, vol: 199, page: 153, stat: Journal Article,

Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of gamma-irradiated cells
Frenkel K; Cummings A; Solomon J; Cadet J; Steinberg JJ; Teebor GW
1985 Aug 13;24(17):4527-4533, Biochemistry
— id: 34055, year: 1985, vol: 24, page: 4527, stat: Journal Article,

Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA
Teebor GW; Frenkel K; Goldstein MS
1984 Jan;81(2):318-321, Proceedings of the National Academy of Sciences of the United States of America
— id: 34057, year: 1984, vol: 81, page: 318, stat: Journal Article,

Protease inhibitors as anticarcinogens
Troll W; Frenkel K; Wiesner R
1984 Dec;73(6):1245-1250, Journal of the National Cancer Institute
— id: 34056, year: 1984, vol: 73, page: 1245, stat: Journal Article,

The initiation of DNA excision-repair
Teebor GW; Frenkel K
1983 ;38(2):23-59, Advances in cancer research
— id: 34059, year: 1983, vol: 38, page: 23, stat: Journal Article,

Free oxygen radicals: necessary contributors to tumor promotion and cocarcinogenesis
Troll W; Frenkel K; Teebor G
1983 ;14(2):207-218, Princess Takamatsu symposia
— id: 34058, year: 1983, vol: 14, page: 207, stat: Journal Article,

Identification of radiation-induced thymine derivatives in DNA
Teebor GW; Frenkel K; Goldstein MS
1982 ;20(2):39-54, Advances in enzyme regulation
— id: 34060, year: 1982, vol: 20, page: 39, stat: Journal Article,

Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid
Frenkel K; Goldstein MS; Duker NJ; Teebor GW
1981 Feb 17;20(4):750-754, Biochemistry
— id: 34063, year: 1981, vol: 20, page: 750, stat: Journal Article,

Identification of the cis-thymine glycol moiety in chemically oxidized and gamma-irradiated deoxyribonucleic acid by high-pressure liquid chromatography analysis
Frenkel K; Goldstein MS; Teebor GW
1981 Dec 22;20(26):7566-7571, Biochemistry
— id: 34061, year: 1981, vol: 20, page: 7566, stat: Journal Article,

Identification of novel 7,12-dimethylbenz[a]anthracene adducts in cellular ribonucleic acid
Frenkel K; Grunberger D; Kasai H; Komura H; Nakanishi K
1981 Jul 21;20(15):4377-4381, Biochemistry
— id: 34062, year: 1981, vol: 20, page: 4377, stat: Journal Article,

STRUCTURE OF A 7,12-DIMETHYLBENZ[A]ANTHRACENE 5,6-OXIDE DERIVATIVE BOUND TO C-8 OF GUANOSINE
NAKANISHI, K; KOMURA, H; MIURA, I; KASAI, H; FRENKEL, K; GRUNBERGER, D
1980 ;20(3):82-83, Journal of the Chemical Society. Chemical communications
— id: 34065, year: 1980, vol: 20, page: 82, stat: Journal Article,

Conformation of dinucleoside monophosphates modified with benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide as measured by circular dichroism
Frenkel K; Grunberger D; Boublik M; Weinstein IB
1978 Apr 4;17(7):1278-1282, Biochemistry
— id: 34064, year: 1978, vol: 17, page: 1278, stat: Journal Article,

STRUCTURES OF 7,12-DIMETHYLBENZ[A]ANTHRACENE 5,6-OXIDE DERIVATIVES LINKED TO RIBOSE MOIETY OF GUANOSINE
KASAI, H; NAKANISHI, K; FRENKEL, K; GRUNBERGER, D
1977 ;99(26):8500-8502, Journal of the American Chemical Society
— id: 34066, year: 1977, vol: 99, page: 8500, stat: Journal Article,

In vitro chemical and biochemical studies on the interaction of the carcinogenic alkylating agents propane sultone and bis-chloromethyl ether with DNA and nucleosides
Frenkel, Krystyna
[S.l. : s.n.], 1975,
— id: 1672, year: 1975, vol: , page: , stat: ,

In vitro chemical and biological studies on the interaction of the carcinogenic alkylating agents propose sultone and bis-chloromethyl ether with DNA and nucleosides
Frenkel, Krystyna
[S.l. : s.n.], 1975,
— id: 1277, year: 1975, vol: , page: , stat: ,

REACTION OF C-14-LABELED BIS-(CHLOROMETHYL) ETHER WITH DNA
Goldschmidt, BM; Vanduuren, BL; Frenkel, K
1975 ;16(MAR):66-66, Proceedings (American Association for Cancer Research)
— id: 28549, year: 1975, vol: 16, page: 66, stat: Journal Article,

REACTION OF PROPANE SULTONE WITH GUANOSINE, ADENOSINE, AND RELATED COMPOUNDS
Goldschm[...], BM; Frenkel, K; Vanduure[...], BL
1974 ;11(5):719-722, Journal of heterocyclic chemistry
— id: 28327, year: 1974, vol: 11, page: 719, stat: Journal Article,

Carcinogenicity of halo-ethers. II. Structure-activity relationships of analogs of bis(chloromethyl)ether
Van Duuren BL; Katz C; Goldschmidt BM; Frenkel K; Sivak A
1972 May;48(5):1431-1439, Journal of the National Cancer Institute
— id: 29245, year: 1972, vol: 48, page: 1431, stat: Journal Article,