Samuel Kenan, M.D.

Metastatic lesions of the proximal femur
Doung, Yee-Cheen; Kenan, Samuel; Rapp, Timothy
2011 ;69(1):81-86, Bulletin of the NYU Hospital for Joint Diseases
Skeletal metastases are common in the adult population. The proximal femur is a frequently affected bone in the appendicular skeleton. The orthopaedic surgeon may be the first to find a pathologic lesion of the proximal femur and appropriate diagnosis and nonoperative management is essential prior to surgical treatment. Bisphosphonates and radiation therapy are used in conjunction with surgical management to minimize pain and prevent further destruction. Surgical management may consist of internal fixation, with or without polymethylmethacrylate, or endoprosthesic replacement. The goal of treatment is to relieve pain and allow for function while minimizing systemic complications
— id: 128799, year: 2011, vol: 69, page: 81, stat: Journal Article,

Total condylar unipolar expandable prosthesis for proximal tibia malignant bone tumors in early childhood
Lozano-Calderon S.A.; Kenan S.
2011 ;34(12):e899-e905, Orthopedics (Thorofare NJ)
Wide resection and reconstruction of tumors of the proximal tibia in the pediatric population are challenging procedures. The use of hinged, expandable prostheses may cause early closure of the distal femoral growth plate, which may increase the risk of limb discrepancy already present in this population. Between 1991 and 2001, 2 girls and 1 boy, aged 6, 6, and 4 years, respectively, were diagnosed with osteosarcoma of the proximal tibia and treated with wide resection and reconstruction with a condylar unipolar expandable tibial prosthesis. A press-fitted technique was used for component insertion. All patients received neoadjuvant and adjuvant chemotherapy. Radiographic and functional follow-up took place at least once a year for a minimum of 4 years. Adequate pain control, limb-length equality, and acceptable function were obtained in all patients. One patient presented with significant range of motion reduction (0degree-30degree) in the affected knee. Limb lengthening was performed as needed to maintain balanced limb length. All patients had a good Musculoskeletal Tumor Society category score. No complications occurred in terms of component loosening or infection. One patient died shortly after 4-year follow-up because of doxorubicin-induced leukemia. Currently used hinged, expandable prostheses can jeopardize the unaffected distal femoral growth plate. This article describes a technique of reconstruction that spares the distal femoral growth plate. Adequate limb length can be expected with acceptable functional outcome. However, it is imperative to keep in perspective the expectations of the physician, the physician's team, the patient, and the patient's family
— id: 148762, year: 2011, vol: 34, page: e899, stat: Journal Article,

Chondrosarcoma of the femur with histology-imaging correlation of tumor growth - preliminary observations concerning periosteal new bone formation and soft tissue extension
Steiner, German C; Schweitzer, Mark E; Kenan, Samuel; Abdelwahab, Ibrahim F
2011 ;69(2):158-167, Bulletin of the NYU Hospital for Joint Diseases
The objective of this study was, in chondrosarcoma (CHS) of the femur, to evaluate by radiologic-pathologic correlation, the degree of tumor growth, cortical destruction, periosteal reaction, and soft tissue extension present. Materials and Methods: Eight cases of histologically proven CHS of the femur were studied. All cases were resected, evaluated histologically with coronal slabs, and compared with radiographs and magnetic resonance imaging (MRI) scans. In two resected specimens, the tumors were studied in more detail; along with coronal slabs, axial sections of the remaining anterior and posterior halves of both tumors were taken, and the bone specimens were X-rayed and examined histologically. Results: CHS initially involved the medullary cavity and subsequently destroyed the cortex; first, by endosteal scalloping and, second, by subsequent invasion and destruction of the cortex. During this process, there was periosteal new bone formation (PNBF), with increased cortical thickness, the degree of which often correlated with the degree of cortical destruction. In the areas of cortical thickening of three cases, a 'grey line' was seen on MRI that separated the cortex from the periosteal new bone; the line, in reality,is a space between the two structures. The presence of this line suggests that the tumor does not extend beyond the cortex. PNBF occurred in all cases and varied in thickness. It frequently developed independent of direct periosteal tumor involvement. The periosteum of one case contained porotic bone with interposed marrow fat, which was easily misinterpreted as tumor extension on MRI. Expansion and remodeling of the femoral diaphysis in CHS, with widening of the medullary cavity, is usually due to extensive cortical destruction with PNBF. Soft tissue extension was present in five cases and apparently occurred by two different mechanisms: direct tumor destruction of the cortex and periosteum, with extension into the soft tissues; and subtle MRI occult tumor permeation through the periosteum. As far as we know, a first literature histologic description of the thickened CHS periosteum also was accomplished. Conclusion: PNBF is a common imaging manifestation of CHS of the femur, which correlated with the degree of cortical destruction. A grey line between the cortex and periosteum is an MRI finding described in this study and may facilitate the evaluation of periosteal thickening and tumor invasion in CHS. PNBF often occurs in the absence of direct periosteal involvement. Periosteal imaging abnormalities suggestive of tumor infltration should be interpreted with caution on MRI, and early soft tissue extension in CHS may be difficult to determine on MRI
— id: 139912, year: 2011, vol: 69, page: 158, stat: Journal Article,

Conventional intramedullary chondrosarcoma with subarticular involvement
Duarte, Maddalena Pizzirusso; Maldjian, Catherine; Katta, Umadevi S; Kenan, Samuel
2008 Jan-Feb;32(1):69-72, Clinical imaging
A 78-year-old female patient with a lesion in the distal tibia is shown to have conventional intramedullary chondrosarcoma. Typical considerations for this end-of-bone neoplastic lesion are giant cell tumor, clear cell chondrosarcoma, and chondroblastoma. Salient clinical and radiographic features and behavior of this lesion broaden the typical view of conventional intramedullary chondrosarcoma
— id: 95703, year: 2008, vol: 32, page: 69, stat: Journal Article,

Re: Ewing's sarcoma of the hip presenting as a benign cyst lesion, Papagelopoulos, P.J., Mavrogenis, A.F., Benetos, I.S., Papaparaskeva, K., Galanis, E.C., Soucacos, P.N., JSOA 16(2):84-88, 2007
Kenan, Samuel
2007 Winter;16(4):207-207, Journal of surgical orthopaedic advances
— id: 95704, year: 2007, vol: 16, page: 207, stat: Journal Article,

Dedifferentiated high-grade osteosarcoma originating from low-grade central osteosarcoma of the fibula
Kenan, Samuel; Ginat, Daniel T; Steiner, German C
2007 Apr;36(4):347-351, Skeletal radiology
Low grade central osteosarcoma is a distinct, rare low grade malignant neoplasm characterized histologically by a spindle cell proliferation associated with trabecular bone formation. This tumor usually carries a good prognosis. However, it has the potential to recur, dedifferentiate, and metastasize subsequent to surgical treatment. In extremely rare occasions, LGCOS presents with areas of dedifferentiation upon initial patient evaluation. In this report we describe one such case affecting the fibula of a 39-year-old female, presenting with pain. Initial biopsy demonstrated a high-grade osteosarcoma. No areas of LGCOS were seen histologically. Following biopsy the patient received 3 months of chemotherapy at a different institution. However, the patient continued to exhibit symptoms. X-rays indicated a very aggressive tumor in the diaphysis of the proximal fibula, MRI revealed soft tissue involvement. The tumor and surrounding soft-tissues were excised en bloc at our institution. Microscopically, the lesion consisted of high-grade osteosarcoma as well as an underlying LGCOS that involved the cortex and medullary cavity of the fibula. The two histological components of the tumor were sharply delineated from one another. No chemotherapy effect was appreciated histologically or clinically. Eight months following the surgery, the patient died from lung metastases. This is the third documented case of dedifferentiated LGCOS at initial presentation. This case reveals that the low-grade component was also evident on preoperative radiographs
— id: 73230, year: 2007, vol: 36, page: 347, stat: Journal Article,

Cortico-medullary continuity in bizarre parosteal osteochondromatous proliferation mimicking osteochondroma on imaging
Rybak, Leon D; Abramovici, Luigia; Kenan, Samuel; Posner, Martin A; Bonar, Fiona; Steiner, German C
2007 Sep;36(9):829-834, Skeletal radiology
Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is an unusual surface-based lesion of bone found most commonly in the hands and feet. In the original description of the lesion and in all publications that followed, one of the key imaging characteristics used to define this entity was the lack of cortico-medullary continuity with the underlying bone. The authors present 4 unique cases of pathologically proven BPOP in which cortico-medullary continuity with the underlying bone was demonstrated on imaging. It is believed that florid reactive periostitis, BPOP and turret osteochondroma may reflect points along the same continuum with trauma the likely inciting event. The authors suggest that, given this continuum, it may be possible to have BPOP lesions demonstrating overlapping imaging features with osteochondroma. If this is the case, strict adherence to the standard imaging criterion of lack of continuity between the lesion and the underlying bone may lead to misdiagnosis of these unusual cases of BPOP as osteochondromas
— id: 78630, year: 2007, vol: 36, page: 829, stat: Journal Article,

Epidermal inclusion cyst of phalanx: a case report and review of the literature
Patel, Keyur; Bhuiya, Tawfiqul; Chen, Sheng; Kenan, Samuel; Kahn, Leonard
2006 Nov;35(11):861-863, Skeletal radiology
Epidermal cyst within a toe phalanx is an extremely rare condition. It is important to differentiate this benign lesion, which can be easily treated by curettage, from other benign and malignant lesions of the bone with a similar clinical presentation, and which may require amputation of the toe. This report describes one such lesion in the mid-phalanx of the fourth toe in a 48-year-old woman, and which was successfully identified by intra-operative frozen diagnosis and treated by curettage
— id: 95705, year: 2006, vol: 35, page: 861, stat: Journal Article,

Osteoarticular allograft of the proximal humerus--histopathological study 18 years after implantation
Ginat, Daniel T; Kenan, Samuel; Steiner, German C
2005 Dec;76(6):934-938, Acta orthopaedica
— id: 62611, year: 2005, vol: 76, page: 934, stat: Journal Article,

Well-differentiated extraosseous chondrosarcoma of the foot with pulmonary metastases
Khaldi, Lubna; Kenan, Samuel; Steiner, German C
2005 Jul;36(7):838-840, Human pathology
We report a case of a 38-year-old man with a well-differentiated extraosseous chondrosarcoma of the foot. This case is unusual because the tumor originated in the soft tissues of the foot and developed pulmonary metastases. It is also interesting to note that at the time of recurrence 8 years later, the lesion invaded the third metatarsophalangeal joint and adjacent bones. Well-differentiated chondrosarcoma resembling hyaline cartilage, primary in soft tissue, is a rare histological type, and only a few cases have been reported in the foot. The patient is alive and well 4.5 years after resection of the foot tumor and partial resection of the lung metastases
— id: 58067, year: 2005, vol: 36, page: 838, stat: Journal Article,

Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis
Weinberg, Jacob; Miller, Theodore T; Handelsman, John E; Kahn, Leonard B; Godfried, David H; Kenan, Samuel
2005 Sep;34(9):539-542, Skeletal radiology
A 9-year-old girl with multiple osteochondromatosis presented with a 1 year history of a gradually enlarging surface lesion originating from the midsection of the right humerus, distal to an osteochondroma. Radiographically and histologically this lesion proved to be a periosteal chondrosarcoma adjacent to an osteochondroma
— id: 95706, year: 2005, vol: 34, page: 539, stat: Journal Article,

Sonographic detection of elastofibroma dorsi
Dalal, Anjali; Miller, Theodore T; Kenan, Samuel
2003 Sep;31(7):375-378, Journal of clinical ultrasound
We describe the case of a 78-year-old man with a large elastofibroma deep to his scapula that was inconspicuous on MRI examination with his arm at his side in neutral position. The mass was not detected sonographically until the patient abducted his arm, allowing the elastofibroma to emerge from under the scapula. The diagnosis of elastofibroma was suggested by the typical sonographic appearance of a hypoechoic mass with interspersed linear echogenicity, resembling muscle. The mass was excised, and the diagnosis was confirmed on histopathologic examination
— id: 95707, year: 2003, vol: 31, page: 375, stat: Journal Article,

True bursal pigmented villonodular synovitis
Abdelwahab, Ibrahim Fikry; Kenan, Samuel; Steiner, German C; Abdul-Quader, Mohammed
2002 Jun;31(6):354-358, Skeletal radiology
We describe two cases of pigmented villonodular synovitis affecting true bursae. This study was also designed to discuss the term 'pigmented villonodular bursitis', not confined to true synovial bursae, sometimes creating misunderstanding
— id: 94867, year: 2002, vol: 31, page: 354, stat: Journal Article,

Coexistence of primary bone tumours: report of 4 cases of collision tumours
Abdelwahab, Ibrahim Fikry; Klein, Michael J; Kenan, Samuel; Hermann, George; Abdul-Quader, Mohammed; Desai, Panna; Yang, David C
2002 Dec;53(5):296-302, Canadian Association of Radiologists journal
OBJECTIVE: To report, in 4 patients, the occurrence of 2 different primary tumours in proximity in the same bone. Three patients had osteosarcomas, and 1 had a giant cell tumour; all had coincident metaphyseal fibrous defect. METHODS: Four patients (2 women, 1 man and 1 boy; 18, 25, 24 and 10 years of age, respectively) presented with progressive pain in the knee and distal thigh. All were studied by radiography, magnetic resonance imaging was done in 3 patients, and diagnostic open biopsy was performed for all. RESULTS: Radiologic studies demonstrated tumours in the distal end of the femur in all 4 patients. Biopsy tissue showed a metaphyseal fibrous defect in all, with coexistence of an associated giant cell tumour in 1 patient and an osteosarcoma in each of the others. In all cases, the metaphyseal fibrous defect was penetrated by the adjacent tumour. CONCLUSIONS: Despite the relative prevalence of metaphyseal fibrous defect, giant cell tumour and osteosarcomas in the distal end of the femur and their occurrence in approximately the same age group, their association has rarely been reported. As both giant cell tumours and osteosarcomas are usually diagnosed late in their clinical course, they may outgrow and destroy any evidence of pre-existing metaphyseal fibrous defect. The rate of destruction is also influenced by the distance between the 2 lesions--the shorter the distance, the earlier the destruction
— id: 81339, year: 2002, vol: 53, page: 296, stat: Journal Article,

Osteoblastoma-like osteosarcoma of the distal tibia
Abramovici, Luigia; Kenan, Samuel; Hytiroglou, Prodromos; Rafii, Mahvash; Steiner, German C
2002 Mar;31(3):179-182, Skeletal radiology
We report a case of a 14-year-old boy with an intracompartmental lytic lesion with poorly defined margins in the right distal tibia that was originally treated with curettage and bone grafting. Histologic examination showed an osteoblastic tumor with unusual features, which was found on consultation to be an osteoblastoma-like osteosarcoma, a rare, low-grade variant of osteosarcoma. Subsequently, the patient underwent en bloc resection of the distal tibia, which was replaced with vascularized bone graft and followed by chemotherapy. Two years later, he is alive with lung metastases
— id: 27571, year: 2002, vol: 31, page: 179, stat: Journal Article,

Parosteal osteosarcoma : impact of medullary involvement and therapy on outcome
Wang BY; Kenan S; Springfield D; Klein MJ
1999 ;12:14A-14A, Modern pathology
— id: 70548, year: 1999, vol: 12, page: 14A, stat: Journal Article,

Parosteal osteosarcoma: impact of medullary involvement and therapy on outcome
Wang, BY; Kenan, S; Springfield, D; Klein, MJ
1999 JAN ;79(1):15A-15A, Laboratory investigation
— id: 70513, year: 1999, vol: 79, page: 15A, stat: Journal Article,

Tuberculous abscess of the brachialis and biceps brachii muscles without osseous involvement. A case report
Abdelwahab IF; Kenan S
1998 Oct;80(10):1521-1524, Journal of bone & joint surgery (American volume)
— id: 57014, year: 1998, vol: 80, page: 1521, stat: Journal Article,

Periosteal ganglia: current concept review
Abdelwahab, I F; Hermann, G; Kenan, S; Klein, M J
1998 Dec;49(6):381-389, Canadian Association of Radiologists journal
— id: 131009, year: 1998, vol: 49, page: 381, stat: Journal Article,

Tuberculous gluteal abscess without bone involvement
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J
1998 Jan;27(1):36-39, Skeletal radiology
A cold abscess secondary to tuberculous spondylitis or osteomyelitis is a well-recognized entity. However, a soft tissue tuberculous abscess without bone involvement is rare. We present such a case
— id: 131012, year: 1998, vol: 27, page: 36, stat: Journal Article,

Bifocal sclerosing osteosarcoma: unusual presentation and course
Abramovici L; Steiner GC; Rosenberg Z; Kenan S
1998 Aug;27(8):449-452, Skeletal radiology
Multifocal osteosarcoma is uncommon. Long-term survival of an incompletely treated case is exceptional. We report an unusual case of bifocal sclerosing osteosarcoma in a 38-year-old women that involved the left ilium and right proximal femur. The femoral lesion was resected. The tumor in the left ilium was not treated. She did not receive chemotherapy and has been free of metastases for 7 years. Recently, growth of the pelvic osteosarcoma has resulted in vascular compression and edema of the lower extremity. The patient's alkaline phosphatase has been elevated throughout. The tumor was HMB-45 positive, which has not been previously reported in osteosarcoma. The pathogenesis of multifocal osteosarcoma is discussed
— id: 7295, year: 1998, vol: 27, page: 449, stat: Journal Article,

Malignant fibrous histiocytoma associated with a bone infarct in a patient with hereditary bone dysplasia
Kenan S; Abdelwahab IF; Hermann G; Klein MJ
1998 Aug;27(8):463-467, Skeletal radiology
Hereditary bone dysplasia (HBD) is an extremely rare clinicopathological entity manifested by diaphyseal medullary stenosis and cortical bone thickening associated with a propensity for fractures affecting the long tubular bone. Malignant transformation has been reported to occur at an alarming frequency. The hereditary pattern appears to be autosomal dominant. In this paper we present the case of a 19-year-old man with hereditary bone dysplasia who was unaware of his underlying condition until he presented with malignant transformation arising in an area of bone infarct of the left tibia
— id: 7367, year: 1998, vol: 27, page: 463, stat: Journal Article,

Dedifferentiated parosteal osteosarcoma of the radius
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J
1997 Apr;26(4):242-245, Skeletal radiology
A 35-year-old woman presented with a painful swelling in the left distal radius that had been present for 1 year. Radiography and computerized tomography revealed a sclerotic surface lesion that had grown over the year and eroded the cortex. Histological examination demonstrated two distinct components: a cartilaginous low- to moderate-grade osteosarcoma on the surface and a high-grade osteosarcoma in the intramedullary component. This case is uncommon in two aspects: the radius is a rare site for such a tumor and the dedifferentiation was revealed at the time of the first surgery and was not secondary to recurrence
— id: 131017, year: 1997, vol: 26, page: 242, stat: Journal Article,

MRI appearance of primary non-Hodgkin's lymphoma of bone
Hermann, G; Klein, M J; Abdelwahab, I F; Kenan, S
1997 Nov;26(11):629-632, Skeletal radiology
OBJECTIVE: To evaluate the signal characteristics of primary non-Hodgkin's lymphoma of bone on MRI. DESIGNS AND PATIENTS: Ten patients with primary non-Hodgkin's lymphoma of bone were included in the study. T1- and T2-weighted imaging was performed. The signal intensity of the lesions was compared with that of the surrounding muscle. RESULTS: The results of the MRI were compared with the histological findings. In the majority of cases (5/10) the lesion involved the femur. In one case each the tibia, humerus, ileum, sacrum, and skull, respectively, were affected. A soft tissue mass was present in four cases. In nine of ten cases on T1-weighted imaging the lesion was hypointense. On T2-weighted imaging seven of ten lesions were hypointense compared with muscle, one isointense and, in two cases, part of the lesion showed slightly hyperintense signal. In all ten cases the signal pattern appeared inhomogeneous. Pathological examination showed extensive fibrosis in the majority of cases. CONCLUSION: According to our results there is decreased signal intensity of bone marrow on both T1- and T2-weighted imaging, unlike other primary round cell tumors of bone. Because the diagnoses were established with small tissue biopsies, the reason for these findings is speculative
— id: 131014, year: 1997, vol: 26, page: 629, stat: Journal Article,

Synovial chondrosarcoma arising in synovial chondromatosis of the right hip
Hermann, G; Klein, M J; Abdelwahab, I F; Kenan, S
1997 Jun;26(6):366-369, Skeletal radiology
The case of a 55-year-old man with chondrosarcoma to the cervical spine is described. Two years previously the patient had undergone a right hip replacement for synovial chondromatosis. Re-evaluation of the biopsy specimen from the right hip taken at the time of the initial operation showed areas of chondrosarcoma arising in the background of synovial chondromatosis. The unusual presentation of this rare entity is discussed
— id: 131016, year: 1997, vol: 26, page: 366, stat: Journal Article,

Fibrocartilaginous dysplasia
Hermann, G; Klein, M; Abdelwahab, I F; Kenan, S
1996 Jul;25(5):509-511, Skeletal radiology
We present the case of a 53-year-old patient with fibrocartilagenous dysplasia. The area involved was in the proximal femur and presented a lytic lesion with extensive calcifications which radiologically mimicked chondrosarcoma. The radiopathological pattern of this rare entity is discussed in detail and the literature reviewed
— id: 131020, year: 1996, vol: 25, page: 509, stat: Journal Article,

Osteoblastoma of the humerus associated with type-I Gaucher's disease. A case report
Kenan, S; Abdelwahab, I F; Hermann, G; Klein, M; Pastores, G
1996 Sep;78(5):702-705, Journal of bone & joint surgery (British volume)
We report a unique case of juxtacortical osteoblastoma of the humeral shaft, which stimulated the appearance of an extraosseous extension of Gaucher-cell deposits. The tumour was treated successfully by curettage and bone grafting. We can find no previous report of this association between osteoblastoma and Gaucher's disease
— id: 131019, year: 1996, vol: 78, page: 702, stat: Journal Article,

Radiation-induced leiomyosarcoma
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J; Lewis, M M
1995 Jan;24(1):81-83, Skeletal radiology
— id: 131030, year: 1995, vol: 24, page: 81, stat: Journal Article,

Intramuscular ganglia arising from the superior tibiofibular joint: CT and MR evaluation
Bianchi, S; Abdelwahab, I F; Kenan, S; Zwass, A; Ricci, G; Palomba, G
1995 May;24(4):253-256, Skeletal radiology
OBJECTIVE: To evaluate the role of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of intramuscular ganglia (IMG) that arise from the superior tibiofibular joint (STFJ). MATERIAL AND METHODS: Our series consisted of three men and three women. Four patients were studied by MRI, one by CT only, and two by both modalities. Contrast was used in one of the two patients studied by CT. MRI was obtained in at least two orthogonal planes to demonstrate the relation of the ganglia to STFJ. RESULTS: The MR and CT appearance of these ganglia was basically that of a well-defined soft tissue mass with low attenuation on CT images consistent with the presence of fluid. On MR studies, they had an isointense signal on T1-weighted images and a homogenous high-intensity signal on T2-weighted images. MRI demonstrated the attachment of these ganglia to the STFJ. CONCLUSION: CT and MRI were effective, noninvasive modalities in the evaluation of IMG. The imaging features on both modalities were consistent with the presence of fluid- containing lesions that had close proximity and were attached to the STFJ. The combination of location and the fluid consistency of these lesions facilitated the diagnosis
— id: 131027, year: 1995, vol: 24, page: 253, stat: Journal Article,

Synovial chondromatosis
Hermann, G; Abdelwahab, I F; Klein, M; Kenan, S; Lewis, M
1995 May;24(4):298-300, Skeletal radiology
— id: 131026, year: 1995, vol: 24, page: 298, stat: Journal Article,

Case report 863. Osteosarcoma associated with giant cell tumor
Kenan, S; Abdelwahab, I F; Klein, M J; Lewis, M M
1995 Jan;24(1):55-58, Skeletal radiology
— id: 131031, year: 1995, vol: 24, page: 55, stat: Journal Article,

Case report 845. Fluid-filling giant cell tumor with an aneurysmal bone cyst component
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J; Lewis, M M
1994 May;23(4):317-319, Skeletal radiology
— id: 131037, year: 1994, vol: 23, page: 317, stat: Journal Article,

Case report 819: Periosteal Ewing's sarcoma of the tibia
Kenan S; Abdelwahab IF; Klein MJ; Hausman MR; Lewis MM
1994 Jan;23(1):59-61, Skeletal radiology
An exceptionally rare case of periosteal Ewing's sarcoma involving the mid shaft of the right tibia was reported. In this case, MRI was the technique that confirmed the integrity of the bone marrow. The clinical, radiographic, and histopathologic features of Ewing's sarcoma have been discussed, as has the differential diagnosis of the periosteal type of this tumor
— id: 35500, year: 1994, vol: 23, page: 59, stat: Journal Article,

Case report 835: Parosteal osteosarcoma involving the left radius
Kenan, S; Abdelwahab, I F; Klein, M J; Hermann, G; Lewis, M M
1994 Apr;23(3):229-231, Skeletal radiology
A case of parosteal osteosarcoma arising in the radius was presented. The site is uncommon, being represented in about 1% of all reported cases of parosteal osteosarcoma. The clinical and radiographic characteristics of this lesion were described and the histological as well as the differential diagnosis discussed
— id: 131041, year: 1994, vol: 23, page: 229, stat: Journal Article,

Case report 864. Elliptical, multicentric periosteal osteoid osteoma
Kenan, S; Abdelwahab, I F; Klein, M J; Hermann, G; Lewis, M M
1994 Oct;23(7):565-568, Skeletal radiology
An extremely rare case of multicentric periosteal osteoid osteoma in a child was presented. The lesions were found to be embedded in a narrow elliptical strip, suggesting the possibility that lesional tissue was stretched in a longitudinal fashion as a result of the rapid skeletal growth. In young patients with stretched periosteal reaction who complain of pain, multicentric osteoid osteoma should be suspected. These nidi can be obscured by the exuberant periosteal reaction. Accurate evaluation of the radiographic findings is very important
— id: 131033, year: 1994, vol: 23, page: 565, stat: Journal Article,

Case report 837: Juxtacortical (periosteal) chondromyxoid fibroma of the proximal tibia
Kenan, S; Abdelwahab, I F; Klein, M J; Lewis, M M
1994 Apr;23(3):237-239, Skeletal radiology
A case of juxtacortical chondromyxoid fibroma in a 31-year-old man was reported. Proof of the diagnosis was obtained by an open biopsy. The histopathology of chondromyxoid fibroma was discussed at length. The radiographic appearances and the differential diagnosis were also described
— id: 131040, year: 1994, vol: 23, page: 237, stat: Journal Article,

Subperiosteal giant-cell reparative granuloma
Kenan, S; Lewis, M M; Abdelwahab, I F; Klein, M
1994 Sep;76(5):810-813, Journal of bone & joint surgery (British volume)
We present a case of subperiosteal giant-cell reparative granuloma followed over six years showing the complete evolution from the early phase of subperiosteal haematoma to the end stage of an ossified haematoma. Such lesions, although they are histologically similar to true giant-cell tumours, can be distinguished by the patients' age, their location on the diaphysis, and by their radiological and histological features
— id: 131034, year: 1994, vol: 76, page: 810, stat: Journal Article,

MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation
Miller, T T; Hermann, G; Abdelwahab, I F; Klein, M J; Kenan, S; Lewis, M M
1994 May;23(4):271-275, Skeletal radiology
We reviewed the magnetic resonance (MR) appearances of 13 malignant fibrous histiocytomas (MFH) of soft tissue and correlated each with the respective lesion's histopathology. The MR images were evaluated for signal intensity on T1- and T2-weighted spin echo sequences, homogeneity of the lesion, presence of internal low signal septations, and margin definition. Histologic subtypes of MFH included storiform-pleomorphic, giant cell, myxoid, and inflammatory. We could not establish a correlation between MR appearance and histopathology. Instead, our series exhibited general features suggestive of malignant soft tissue neoplasms, namely poor margin definition, internal low signal septation, and heterogeneous high signal intensity on T2-weighted images
— id: 131038, year: 1994, vol: 23, page: 271, stat: Journal Article,

Case report 839: Elastofibroma of the right shoulder causing brachial plexus impingement
Pechman, D; Kenan, S; Abdelwahab, I F; Klein, M J; Lewis, M M
1994 Aug;23(6):459-461, Skeletal radiology
A case of an elastofibroma in the right scapular region in a 56-year-old woman was reported. The clinical and pathological findings were discussed. The location of this lesion was uncommon. The common sites were mentioned. The differential diagnosis and magnetic resonance findings were also described
— id: 131035, year: 1994, vol: 23, page: 459, stat: Journal Article,

Case report 810: Giant cell tumor of the first metatarsal
Aaron AD; Kenan S; Klein MJ; Hausman MR; Abdelwahab IF; Lewis MM
1993 Oct;22(7):543-545, Skeletal radiology
And unusual case of giant cell tumor in a 3-year-old girl has been presented. The topic of giant cell tumors has been discussed at length. The pathology and the differential diagnosis have been considered. The incidence of giant cell tumors in children and adolescents has also been reviewed and proved to be extremely rare
— id: 35501, year: 1993, vol: 22, page: 543, stat: Journal Article,

Case report 794. Primary leiomyosarcoma of the right femur (fig. 4)
Abdelwahab, I F; Hermann, G; Kenan, S; Klein, M J; Lewis, M M
1993 ;22(5):379-381, Skeletal radiology
A rare case of primary leiomyosarcoma of the proximal end of the shaft of the right femur in a 52-year-old man has been reported. Proof was obtained by an open biopsy. The origin, pathological features, and clinical presentation have been discussed. The radiographic appearance, the differential diagnosis, and the poor prognosis of this tumor have also been indicated
— id: 131057, year: 1993, vol: 22, page: 379, stat: Journal Article,

Intramuscular myxoma of the left forearm
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J; Lewis, M M
1993 Summer;53(3):15-17, Bulletin (Hospital for Joint Diseases)
Intramuscular myxoma is a distinct benign tumor confined to muscles. This tumor usually favors the thigh and shoulder. We are reporting a case of intramuscular myxoma of the forearm in an elderly female, a very rare site for this tumor. The magnetic resonance features of intramuscular myxoma are described. The differential diagnosis that included acute hematoma, acute abscess, intramuscular synovial cyst, schwannoma and malignant soft tissue tumors with myxomatous degeneration is discussed. The association between intramuscular myxomas and fibrous dysplasia has been emphasized
— id: 131047, year: 1993, vol: 53, page: 15, stat: Journal Article,

Periosteal ganglia: CT and MR imaging features
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J; Lewis, M M
1993 Jul;188(1):245-248, Radiology
The imaging features of four cases of periosteal ganglia were studied. Three lesions were located over the proximal shaft of the tibia, in proximity to the pes anserinus. The fourth lesion involved the distal shaft of the ulna. Three lesions had different degrees of external cortical erosion, scalloping, and thick spicules of periosteal bone on plain radiographs. The bone adjacent to the fourth lesion was not involved. Computed tomography (CT) showed these lesions to be sharply defined soft-tissue masses abutting the periosteum. All of the lesions had the same attenuation as fluid. Magnetic resonance (MR) imaging revealed the ganglia to be sharply defined masses that were isointense compared with neighboring muscles on T1-weighted images. There was markedly increased signal intensity compared with that of fat on T2-weighted images. The signal intensity on both types of images was homogeneous. The MR imaging features were consistent with the fluid nature of the lesions. Under the appropriate clinical circumstances, the MR imaging and CT features of periosteal ganglia are diagnostic
— id: 131050, year: 1993, vol: 188, page: 245, stat: Journal Article,

Tuberculous peroneal tenosynovitis. A case report
Abdelwahab, I F; Kenan, S; Hermann, G; Klein, M J; Lewis, M M
1993 Nov;75(11):1687-1690, Journal of bone & joint surgery (American volume)
— id: 131043, year: 1993, vol: 75, page: 1687, stat: Journal Article,

Eosinophilic granuloma of the left ischium
Abdelwahab, I F; Tenreiro, R; Hermann, G; Kenan, S; Lewis, M M; Klein, M J
1993 Winter;52(2):62-64, Bulletin (Hospital for Joint Diseases)
A case of eosinophilic granuloma in an unusual location (ischium) is presented. Eosinophilic granuloma, a benign lesion of bone, has many radiographic appearances that vary with location. The flat bone of the skull and pelvis are common sites of involvement. Although the iliac wings and pubic rami are not uncommon sites for such a lesion, the ischium is a rare site. This occurrence prompted us to report this case
— id: 131052, year: 1993, vol: 52, page: 62, stat: Journal Article,

Case report 773. Radiation-induced osteochondroma of the ilium
DeSimone, D P; Abdelwahab, I F; Kenan, S; Klein, M J; Lewis, M M
1993 ;22(2):135-137, Skeletal radiology
A case of osteochondroma of the pelvis secondary to radiation therapy after radical nephrectomy for a Wilm's tumor is reported. The occurrence of such a complication is discussed. Proof was obtained by open biopsy. The indications for surgical resection of such a tumor were considered. The differential diagnosis, although limited in scope, was discussed
— id: 131054, year: 1993, vol: 22, page: 135, stat: Journal Article,

Case report 785: Radiation-induced osteochondroma of the ilium
DeSimone, D P; Abdelwahab, I F; Kenan, S; Klein, M J; Lewis, M M
1993 ;22(4):289-291, Skeletal radiology
A case of osteochondroma of the pelvis secondary to radiation therapy after radical nephrectomy for a Wilm's tumor is reported. The occurrence of such a complication has been discussed. Proof was obtained by open biopsy. The indications for surgical resection of such a tumor were considered. The differential diagnosis, though limited, was discussed
— id: 131053, year: 1993, vol: 22, page: 289, stat: Journal Article,

Case report 795. High-grade surface osteosarcoma of the radius
Hermann, G; Abdelwahab, I F; Kenan, S; Lewis, M M; Klein, M J
1993 ;22(5):383-385, Skeletal radiology
We described a case of high-grade surface sarcoma of the radius in a 14-year-old boy. The lesion appeared radiologically benign and was confined to the surface. The tumor was resected. At the time of biopsy both lungs showed diffuse metastases. Following surgery the patient underwent chemotherapy and the lung metastases improved. The pertinent literature was briefly discussed
— id: 131056, year: 1993, vol: 22, page: 383, stat: Journal Article,

Case report 796. Alveolar soft part sarcoma
Hermann, G; Abdelwahab, I F; Klein, M J; Kenan, S; Lewis, M M
1993 ;22(5):386-389, Skeletal radiology
We have presented a young adult with alveolar soft part sarcoma. The lesion occurred in the ankle region and caused extensive bony erosion that mimicked metastasis. At the time of presentation, gingival and subcutaneous metastases were present. Within a short period, however, the patient developed disseminated lung and skeletal metastases as well
— id: 131055, year: 1993, vol: 22, page: 386, stat: Journal Article,

Lesions of juxtacortical origin (surface lesions of bone)
Kenan, S; Abdelwahab, I F; Klein, M J; Hermann, G; Lewis, M M
1993 ;22(5):337-357, Skeletal radiology
A large variety of tumor and tumor-like conditions have been shown to originate from the surface of bone (Table 1). Most surface lesions are associated with periosteal reaction. The periosteum is a multipotential membrane. Its cellular composition may give rise to a variety of both neoplasms and tumor-like conditions. To avoid misinterpretation, the orthopedist, radiologist, and pathologist should be familiar with the entire spectrum of surface lesions. A better understanding of the natural history and biological behavior at different lesional maturity stages and correlation of the history with the radiographic and pathological findings is essential to establish the correct diagnosis. A history of injury or blunt trauma is very important. A stress fracture may produce a periosteal reaction acd callus that can be difficult to distinguish from osteosarcoma. In this review article, the authors wish to describe and define each term by its anatomy and radiographic features while discussing the entire spectrum of surface lesions. All the illustrative cases in this review article have been proven histologically
— id: 131058, year: 1993, vol: 22, page: 337, stat: Journal Article,

Case report 817: Synovial chondrosarcoma secondary to synovial chondromatosis
Kenan, S; Abdelwahab, I F; Klein, M J; Lewis, M M
1993 Nov;22(8):623-626, Skeletal radiology
A case of prolonged history of synovial chondromatosis of the knee joint that transformed into low-grade chondrosarcoma was reported. The pathological differentiation of this rare entity from synovial chondromatosis has been discussed, as have the radiographic appearance and differential diagnosis
— id: 131044, year: 1993, vol: 22, page: 623, stat: Journal Article,

Neuropathic arthropathy of the shoulder mimicking soft tissue sarcoma
Kenan, S; Lewis, M M; Main, W K; Hermann, G; Abdelwahab, I F
1993 Oct;16(10):1133-1136, Orthopedics (Thorofare NJ)
— id: 131045, year: 1993, vol: 16, page: 1133, stat: Journal Article,

Simple bone cysts: true recurrence after complete obliteration
Seckler, M M; Kenan, S; Desimone, D; Abdelwahab, I F; Lewis, M M
1993 1995;53(4):50-53, Bulletin (Hospital for Joint Diseases)
A report of recurrent simple bone cysts in two cases--a seven-year-old and a six-year-old male--is presented. In each case curettage and cortical banked bone graft were performed. On follow-up, there was no clinical or radiographic evidence of further recurrence
— id: 131051, year: 1993, vol: 53, page: 50, stat: Journal Article,

The role of microvascular surgery in limb-sparing procedures for malignant tumors of the knee
Weinberg H; Kenan S; Lewis MM; Hausman MR; Vickery CB; Bloom ND
1993 Sep;92(4):692-698, Plastic & reconstructive surgery
Limb-sparing surgery has proven to be a feasible alternative to amputation for treatment of malignant tumors about the knee. Microvascular surgery and the possibility of providing healthy, stable soft-tissue coverage to the affected limb have expanded the possible role of limb-sparing techniques. Microvascular free flaps were utilized in 26 patients undergoing resection for large malignant tumors of the knee or adjacent to the knee. Patients were then followed for a minimum of 3 years to a maximum of 7 years and evaluated for tumor recurrence and limb function. Survival and disease-free interval were 68 and 77 percent, respectively, in stage II patients and only 50 and 0 percent, respectively, in stage III patients. Function, as determined by the MSTS functional evaluation system, was found to be fair to good in all patients. Microvascular free-tissue transfer has proven to be a valuable adjunct in limb-sparing surgery
— id: 35502, year: 1993, vol: 92, page: 692, stat: Journal Article,

Case report: angiosarcoma occurring in a bone infarct
Abdelwahab, I F; Kenan, S; Klein, M J; Lewis, M M
1992 Jun;45(6):412-414, Clinical radiology
An unusual case of an angiosarcoma that occurred in a bone infarct is presented. A bone infarct may occasionally dedifferentiate to an osteogenic sarcoma or a malignant fibrous histocytoma. However, the association of angiosarcoma with a bone infarct is extremely rare. To the best of our knowledge, there is only one other report of this association in the English literature
— id: 131062, year: 1992, vol: 45, page: 412, stat: Journal Article,

Case report 711: Parosteal osteosarcoma of left femur
Hermann, G; Abdelwahab, I F; Klein, M J; Kenan, S; Lewis, M M
1992 ;21(1):69-71, Skeletal radiology
We present a patient with parosteal osteosarcoma. The lesion arose at the surface of the femur without involvement of the marrow cavity. Some 24 months following resection of the involved bone, she developed distant metastases with no evidence of local recurrence. Neither the primary nor the metastatic lesions showed high-grade malignancy
— id: 131066, year: 1992, vol: 21, page: 69, stat: Journal Article,

Case report 754: Xanthoma of the Achilles tendon
Kenan, S; Abdelwahab, I F; Klein, M J; Aaron, A; Lewis, M M
1992 ;21(7):471-473, Skeletal radiology
The MRI features of bilateral xanthoma of the achilles tendon in type II hyperlipoproteinemia are reported. MRI has proved to be the best imaging modality available in assessing enlargement of the Achilles tendon. It demonstrates the heterogeneous signal on both T1- and T2-weighted images where the xanthomatous deposits are relatively higher in signal intensity than the tendon itself. MRI also has a potential value in the clinical assessment and therapeutic response of the xanthoma after operative intervention
— id: 131067, year: 1992, vol: 21, page: 471, stat: Journal Article,

Hemangiomas of the long tubular bone
Kenan, S; Abdelwahab, I F; Klein, M J; Lewis, M M
1992 Jul;(280):256-260, Clinical orthopaedics & related research
The overall spectrum of hemangiomas involving long tubular bones is exemplified by three cases, the first being medullary, the second periosteal, and the third intracortical. The clinical presentation was progressive pain at the site of the lesion in all cases. The medullary hemangioma involved the distal shaft of the humerus and was entirely radiolucent. The periosteal tumor was exceptional in that it affected the proximal shaft of the tibia in contrast to the seven previously reported cases that involved the midshaft of the bone. The intracortical hemangioma was in the tibia, the site of all three previously reported cases. Hemangioma of bone may show variable roentgenographic patterns related to the anatomic location and the type of involved bone. The final diagnosis is dependent on histologic evaluation
— id: 131061, year: 1992, vol: , page: 256, stat: Journal Article,

Fibromyxoma of bone
Abdelwahab, I F; Hermann, G; Klein, M J; Kenan, S; Lewis, M M
1991 ;20(2):95-98, Skeletal radiology
We report two cases of fibromyxoma, one affecting the iliac crest and the second involving the proximal shaft of the tibia. Fibromyxoma is a rare neoplasm related to benign fibrous tumors and is characterized by exuberant, extracellular, ground substance production. Its histologic appearance is benign and distinctive and can be readily distinguished from that of myxoid chondrosarcoma or chondromyxoid fibroma. The radiographic picture is, however, difficult to interpret, and the entity can be easily mistaken for other tumors
— id: 131075, year: 1991, vol: 20, page: 95, stat: Journal Article,

Case report 696: Chondroblastoma of the right acetabulum and superior pubic ramus
Abdelwahab, I F; Hermann, G; Klein, M J; Silver, A; Kenan, S; Lewis, M M
1991 ;20(7):547-549, Skeletal radiology
A case of chondroblastoma involving the right acetabulum and superior pubic ramus in a 60-year-old man has been presented. Tissue was obtained by open biopsy. The clinical and radiographic characteristics of chondroblastoma in general, and this tumor in particular, were discussed. The histopathology and differential diagnosis were also considered. The relatively uncommon site of the tumor and its occurrence in an older patient made the radiographic diagnosis difficult, and other possibilities were discussed
— id: 131078, year: 1991, vol: 20, page: 547, stat: Journal Article,

Simple bone cysts of the pelvis in adolescents. A report of four cases
Abdelwahab, I F; Hermann, G; Norton, K I; Kenan, S; Lewis, M M; Klein, M J
1991 Aug;73(7):1090-1094, Journal of bone & joint surgery (American volume)
— id: 131072, year: 1991, vol: 73, page: 1090, stat: Journal Article,

Atypical skeletal tuberculosis mimicking neoplasm
Abdelwahab, I F; Kenan, S; Hermann, G; Lewis, M; Klein, M; Rabinowitz, J G
1991 Jun;64(762):551-555, British journal of radiology
— id: 131073, year: 1991, vol: 64, page: 551, stat: Journal Article,

Transarticular invasion of joints by bone tumors: hypothesis
Abdelwahab, I F; Miller, T T; Hermann, G; Klein, M J; Kenan, S; Lewis, M M
1991 ;20(4):279-283, Skeletal radiology
Eight bone tumors with associated transarticular invasion of the sacroiliac joints are described. All invaded the true synovial joint and spread to the opposing bone. One tumor was benign, and the other seven were malignant. Five of the seven were primary and two were metastatic cancer. One, a myeloma, invaded the disc spaces between the fourth and fifth lumbar vertebrae and the fifth lumbar vertebra and sacrum as well as the sacroiliac joint. The right facet joints of the two vertebrae were also invaded. After a thorough search of the literature, we find that the sacroiliac joint is the most common joint to be invaded by tumors. This is followed by the vertebral disc spaces and, last, the facet joints. Apart from these joints, we were unable to find any radiographic documentation of other joints being transarticularly invaded by tumors. We noted that there is a direct relation between transarticular tumor spread and joints that lack mobility and that certain tumors, benign and malignant, tend to invade these joints
— id: 131077, year: 1991, vol: 20, page: 279, stat: Journal Article,

Case report 652: Primary intraosseous low grade myxoid sarcoma of the scapula (myxoid liposarcoma)
Kenan, S; Lewis, M M; Abdelwahab, I F; Hermann, G; Klein, M J
1991 ;20(1):73-75, Skeletal radiology
A case of primary liposarcoma of bone involving the glenoid region of the right scapula in a 57-year-old man is presented. The diagnosis was confirmed by open biopsy. The differential diagnoses have been considered. To the best of our knowledge, this may be the first reported case of primary liposarcoma of bone in the scapula
— id: 131076, year: 1991, vol: 20, page: 73, stat: Journal Article,

EXPERIMENTAL TRANSPLANTATION OF THE SWARM RAT CHONDROSARCOMA INTO BONE - RADIOLOGICAL AND PATHOLOGICAL-STUDIES
Kenan, S; Steiner, GC
1991 May;9(3):445-451, Journal of orthopaedic research
The Swarm rat chondrosarcoma has been the subject of extensive biochemical studies. However, to our knowledge, there are no previous reports in the literature on transplantation of this tumor into bone. This article describes the natural history of the tumor when implanted into the bone of the rat, and correlates its histological growth pattern with its radiological appearance. Our results showed that the tumor grows slowly in the bone. The rate of intramedullary growth, however, was variable and was not the same in all the animals. Its growth pattern resembles human chondrosarcoma, with extensive invasion of the marrow and cortex. In the first few weeks after implantation, the only radiological changes noted were mild medullary radiopacities. At a later stage, 12-14 weeks postimplantation, as the tumor infiltrated the bone, significant radiological abnormalities were observed in the medullary cavity and cortex. Periosteal reaction was seen after the tumor invaded the cortex with the production of a soft-tissue mass. Distant dissemination was rare; only 1 of 24 rats developed pulmonary metastases. The Swarm rat chondrosarcoma is a well-differentiated malignant tumor that histologically resembles well-differentiated human chondrosarcoma. Transplanted into bone, it may be useful as an experimental model for comparative studies with human chondrosarcoma
— id: 32220, year: 1991, vol: 9, page: 445, stat: Journal Article,

Case report 635. Chondroblastoma of the fourth metatarsal bone with secondary aneurysmal bone cyst
Abdelwahab, I F; Hermann, G; Klein, M J; Kenan, S; Lewis, M M
1990 ;19(7):539-541, Skeletal radiology
— id: 131089, year: 1990, vol: 19, page: 539, stat: Journal Article,

Case report 623. Osteitis condensans of the left clavicle (OCC)
Abdelwahab, I F; Hermann, G; Ramos, R; Klein, M J; Kenan, S; Lewis, M M
1990 ;19(5):387-389, Skeletal radiology
A case of OCC in a 35-year-old woman is presented. Proof was obtained by open biopsy. This rare entity is benign and its etiology is still obscure. No definite association with osteitis pubis or osteitis condensans ilii has been reported. The involvement of the clavicle is invariably unilateral. The clinical and radiographic characteristics of this benign condition have been discussed and the differential diagnosis has been considered. Consideration should be given to the concept that if the imaging features are characteristic, as in this case, biopsy may not be necessary
— id: 131084, year: 1990, vol: 19, page: 387, stat: Journal Article,

Case report 644: Localized Paget's disease of the lesser trochanter of the right femur
Hermann, G; Abdelwahab, I F; Klein, M J; Kenan, S
1990 ;19(8):613-615, Skeletal radiology
— id: 131088, year: 1990, vol: 19, page: 613, stat: Journal Article,

CO2 laser cauterization of giant-cell tumor margins
Kirby EJ; Buchalter JS; Kastenbaum DM; Kenan S; Kummer FJ; Lewis MM
1990 Apr;(253):231-239, Clinical orthopaedics & related research
The CO2 laser was evaluated to determine its effectiveness for marginal cauterization of giant-cell tumors after resectional curettage. Average power densities of 11-53 W/cm2 for corresponding application times of 120 and 60 seconds were found to produce 30 degrees temperature rises in fresh human femoral heads. This temperature was adequate to achieve thermal necrosis of the tumor margins to a depth of 5 mm. CO2 laser resection was found to be accurate and reproducible. No damage to underlying hyaline cartilage and soft tissues was evident histologically at one and four weeks after experimental local laser cauterization of distal femoral condyles in rabbits
— id: 47549, year: 1990, vol: , page: 231, stat: Journal Article,

Malignant transformation of fibrous dysplasia. A case report and review of the literature
Yabut SM Jr; Kenan S; Sissons HA; Lewis MM
1988 Mar;(228):281-289, Clinical orthopaedics & related research
A 34-year-old man developed a spindle-cell sarcoma originating in a preexisting lesion of monostotic fibrous dysplasia. A review of the literature reveals 83 cases of a malignant degeneration in fibrous dysplasia; osteosarcoma was the most common type of tumor. The next most common were fibrosarcoma and chondrosarcoma. The malignant tumor usually developed in the third or fourth decade of life. The most frequent anatomic sites were the craniofacial bones, the femur, and the tibia. Twenty-three of the 83 cases were treated with local radiation. In fibrous dysplasia, any abrupt alteration in the clinical course, manifested by pain and swelling, raises the possibility of malignant degeneration
— id: 47574, year: 1988, vol: , page: 281, stat: Journal Article,

Cord compression as the presenting symptom of extradural malignant lymphoma
Margulies, J Y; Kenan, S; Michowitz, S D; Okon, E; Peretz, T; Matzner, Y; Floman, Y
1987 ;106(5):291-296, Archives of orthopaedic & traumatic surgery = Archiv fur orthopadische und Unfall-Chirurgie
Six patients with spinal cord compression as the presenting symptom of malignant lymphoma are described. These patients suffered from back pain for several months and were diagnosed after sudden paraparesis appeared. Five patients were treated by operative decompression followed by local irradiation, and all regained their motor function. A sixth patient presented with a more insidious paraparesis. A bone marrow aspiration established the diagnosis of malignant lymphoma, and this patient recovered with radiation and steroids alone. Thus, we recommend considering malignant lymphoma as a possible cause of acute cord compression, attempting to establish the diagnosis on an emergency basis within several hours, and attempting to achieve decompression with local radiotherapy and intravenous dexamethasone
— id: 146873, year: 1987, vol: 106, page: 291, stat: Journal Article,