David Keefe

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David Keefe, M.D.

Professor; Stanley H. Kaplan Professor and Chairman of Obstetrics and Gynecology; Stanley H Kaplan Chr Dept Obstertrics & Gynecology
Departments of Obstetrics and Gynecology (Obs/Gyn) and Cell Biology (Cell Biology)

Clinical Addresses

NYU Fertility Center
NEW YORK, NY 10016
Hours: Tue. 1 - 4; Fri. 9 - 1
Handicap Access: yes
Phone: 212-263-3360
Fax: 212-263-7853

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Medical Specialties

Obstetrics/Gynecology, Gynecology

Medical Expertise

Fibroids, Endometriosis, Invitro Fertilization, Recurrent Pregnancy Loss, Infertility, Abnormal Uterine Bleeding, Reproductive Endocrinology, Age and Infertility, General Gynecology, Myomectomy, Peri-Menopause, Menopause/Perimenopause

Clinical Responsibilities

I am a board-certified, fellowship-trained gynecologist specializing in the care, diagnosis and treatment of women with infertility and reproductive endocrine disorders. I am a specialist in infertility treatment, including in vitro fertilization.





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Board Certification

1993 — Ab Obstetrics & Gynecology - Obstetrics & Gynecology
1995 — Ab Obstetrics & Gynecology (Reproduc Endocrin & Infertility)


1976-1980 — Georgetown University School of Medicine, Medical Education
1980-1981 — Mount Auburn Hospital (Medicine), Residency Training
1981-1982 — Cambridge Hospital (Psychiatry), Residency Training
1982-1985 — Northwestern University (Neuro-endocrinology), Clinical Fellowships
1982-1985 — University of Chicago (Psychiatry), Residency Training
1985-1989 — Yale New Haven Hospital (Obstetrics & Gynecology), Residency Training
1989-1991 — Yale University School of Medicine (Reproductive Endocrinology), Clinical Fellowships
1991-1992 — Yale University School of Medicine (Reproductive Endocrinology), Clinical Fellowships

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Research Interests

Reproductive aging, Oocyte dysfunction, telomeres, meiosis, stem cells

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All data from NYU Health Sciences Library Faculty Bibliography — -


Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing
Dan, Jiameng; Liu, Yifei; Liu, Na; Chiourea, Maria; Okuka, Maja; Wu, Tao; Ye, Xiaoying; Mou, Chunlin; Wang, Lei; Wang, Lingling; Yin, Yu; Yuan, Jihong; Zuo, Bingfeng; Wang, Fang; Li, Zhiguo; Pan, Xinghua; Yin, Zhinan; Chen, Lingyi; Keefe, David L; Gagos, Sarantis; Xiao, Andrew; Liu, Lin
2014 Apr;29(1):7-19, Developmental cell
— id: 882072, year: 2014, vol: 29, page: 7, stat: Journal Article,

Telomere Length Reprogramming in Embryos and Stem Cells
Kalmbach, Keri; Robinson, Leroy G Jr; Wang, Fang; Liu, Lin; Keefe, David
2014 ;2014:925121-925121, BioMed research international
— id: 953452, year: 2014, vol: 2014, page: 925121, stat: Journal Article,

Telomere length, family history, and paternal age in schizophrenia
Malaspina, Dolores; Dracxler, Roberta; Walsh-Messinger, Julie; Harlap, Susan; Goetz, Raymond R; Keefe, David; Perrin, Mary C
2014 Jul;2(4):326-331, Molecular genetics & genomic medicine
— id: 1090242, year: 2014, vol: 2, page: 326, stat: Journal Article,

Breastfeeding status and maternal cardiovascular variables across the postpartum
Groer, Maureen W; Jevitt, Cecilia M; Sahebzamani, Frances; Beckstead, Jason W; Keefe, David L
2013 May;22(5):453-459, Journal of women's health (Larchmont, N.Y. : 2002)
— id: 361912, year: 2013, vol: 22, page: 453, stat: Journal Article,

Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke
Huang, Junjiu; Okuka, Maja; Lu, Weisi; Tsibris, John C M; McLean, Mark P; Keefe, David L; Liu, Lin
2013 Jan;35:89-95, Reproductive toxicology
— id: 956522, year: 2013, vol: 35, page: 89, stat: Journal Article,

Ovarian aging: breaking up is hard to fix
Johnson, Joshua; Keefe, David L
2013 Feb;5(172):172fs5-172fs5 172fs5, Science translational medicine
— id: 956532, year: 2013, vol: 5, page: 172fs5, stat: Journal Article,

A statement on abortion by 100 professors of obstetrics: 40 years later
Keefe, David; et al
2013 Sep;209(3):193-199, American journal of obstetrics & gynecology
— id: 557232, year: 2013, vol: 209, page: 193, stat: Journal Article,

Resveratrol protects against age-associated infertility in mice
Liu, Mengyuan; Yin, Yu; Ye, Xiaoying; Zeng, Ming; Zhao, Qiang; Keefe, David L; Liu, Lin
2013 Mar;28(3):707-717, Human reproduction
— id: 249062, year: 2013, vol: 28, page: 707, stat: Journal Article,

Robust measurement of telomere length in single cells
Wang, Fang; Pan, Xinghua; Kalmbach, Keri; Seth-Smith, Michelle L; Ye, Xiaoying; Antumes, Danielle M F; Yin, Yu; Liu, Lin; Keefe, David L; Weissman, Sherman M
2013 May;110(21):E1906-E1912, Proceedings of the National Academy of Sciences of the United States of America
— id: 353282, year: 2013, vol: 110, page: E1906, stat: Journal Article,

No evidence for neo-oogenesis may link to ovarian senescence in adult monkey
Yuan, Jihong; Zhang, Dongdong; Wang, Lei; Liu, Mengyuan; Mao, Jian; Yin, Yu; Ye, Xiaoying; Liu, Na; Han, Jihong; Gao, Yingdai; Cheng, Tao; Keefe, David L; Liu, Lin
2013 Nov;31(11):2538-2550, Stem cells
— id: 687472, year: 2013, vol: 31, page: 2538, stat: Journal Article,

Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC)
Liu, Jinmiao; Liu, Mengyuan; Ye, Xiaoying; Liu, Kai; Huang, Junjiu; Wang, Lingling; Ji, Guangzhen; Liu, Na; Tang, Xiangdong; Baltz, Jay M; Keefe, David L; Liu, Lin
2012 May;27(5):1411-1420, Human reproduction
— id: 166884, year: 2012, vol: 27, page: 1411, stat: Journal Article,

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells
Wang, Fang; Yin, Yu; Ye, Xiaoying; Liu, Kai; Zhu, Haiying; Wang, Lingling; Chiourea, Maria; Okuka, Maja; Ji, Guangzhen; Dan, Jiameng; Zuo, Bingfeng; Li, Minshu; Zhang, Qian; Liu, Na; Chen, Lingyi; Pan, Xinghua; Gagos, Sarantis; Keefe, David L; Liu, Lin
2012 Apr;22(4):757-768, Cell research
— id: 166038, year: 2012, vol: 22, page: 757, stat: Journal Article,

Association of telomere length with authentic pluripotency of ES/iPS cells
Huang, Junjiu; Wang, Fang; Okuka, Maja; Liu, Na; Ji, Guangzhen; Ye, Xiaoying; Zuo, Bingfeng; Li, Minshu; Liang, Ping; Ge, William W; Tsibris, John Cm; Keefe, David L; Liu, Lin
2011 May;21(5):779-792, Cell research
— id: 133642, year: 2011, vol: 21, page: 779, stat: Journal Article,

Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary
Liu, Zhong; Hu, Zhe; Pan, Xinghua; Li, Minshu; Togun, Taiwo A; Tuck, David; Pelizzola, Mattia; Huang, Junjiu; Ye, Xiaoying; Yin, Yu; Liu, Mengyuan; Li, Chao; Chen, Zhisheng; Wang, Fang; Zhou, Lingjun; Chen, Lingyi; Keefe, David L; Liu, Lin
2011 Apr 1;20(7):1339-1352, Human molecular genetics
— id: 133643, year: 2011, vol: 20, page: 1339, stat: Journal Article,

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
Agarwal, Suneet; Loh, Yuin-Han; McLoughlin, Erin M; Huang, Junjiu; Park, In-Hyun; Miller, Justine D; Huo, Hongguang; Okuka, Maja; Dos Reis, Rosana Maria; Loewer, Sabine; Ng, Huck-Hui; Keefe, David L; Goldman, Frederick D; Klingelhutz, Aloysius J; Liu, Lin; Daley, George Q
2010 Mar 11;464(7286):292-296, Nature
— id: 133647, year: 2010, vol: 464, page: 292, stat: Journal Article,

Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro
Huang, Junjiu; Okuka, Maja; McLean, Mark; Keefe, David L; Liu, Lin
2010 Jun 15;48(12):1663-1676, Free radical biology & medicine
— id: 133645, year: 2010, vol: 48, page: 1663, stat: Journal Article,

Generation of pluripotent stem cells from eggs of aging mice
Huang, Junjiu; Okuka, Maja; Wang, Fang; Zuo, Bingfeng; Liang, Ping; Kalmbach, Keri; Liu, Lin; Keefe, David L
2010 Apr;9(2):113-125, Aging cell
— id: 133646, year: 2010, vol: 9, page: 113, stat: Journal Article,

Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis
Liu, Na; Enkemann, Steven A; Liang, Ping; Hersmus, Remko; Zanazzi, Claudia; Huang, Junjiu; Wu, Chao; Chen, Zhisheng; Looijenga, Leendert H J; Keefe, David L; Liu, Lin
2010 Dec;2(6):333-344, Journal of molecular cell biology
— id: 133644, year: 2010, vol: 2, page: 333, stat: Journal Article,

Maintenance of blood-pressure-lowering effect following a missed dose of aliskiren, irbesartan or ramipril: results of a randomized, double-blind study
Palatini, P; Jung, W; Shlyakhto, E; Botha, J; Bush, C; Keefe, D L
2010 Feb;24(2):93-103, Journal of human hypertension
— id: 101969, year: 2010, vol: 24, page: 93, stat: Journal Article,

Frozen hope: fertility preservation for women with cancer
Quinn, Gwendolyn P; Vadaparampil, Susan T; Jacobsen, Paul B; Knapp, Caprice; Keefe, David L; Bell, Geri E
2010 Mar-Apr;55(2):175-180, Journal of midwifery & women's health
— id: 144118, year: 2010, vol: 55, page: 175, stat: Journal Article,

Birth of Parthenote Mice Directly from Parthenogenetic Embryonic Stem Cells
Chen, Zhisheng; Liu, Zhong; Huang, Junjiu; Amano, Tomokazu; Li, Chao; Cao, Shanbo; Wu, Chao; Liu, Bodu; Zhou, Lingjun; Carter, Mark G; Keefe, David L; Yang, Xiangzhong; Liu, Lin
2009 Sep;27(9):2136-2145, Stem cells
— id: 101968, year: 2009, vol: 27, page: 2136, stat: Journal Article,

Effects of cigarette smoke on fertilization and embryo development in vivo
Huang, Junjiu; Okuka, Maja; McLean, Mark; Keefe, David L; Liu, Lin
2009 Oct;92(4):1456-1465, Fertility & sterility
— id: 101972, year: 2009, vol: 92, page: 1456, stat: Journal Article,

Telomeres and reproductive aging
Keefe, David L; Liu, Lin
2009 ;21(1):10-14, Reproduction, fertility & development
— id: 101971, year: 2009, vol: 21, page: 10, stat: Journal Article,

Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells
Li, Chao; Chen, Zhisheng; Liu, Zhong; Huang, Junjiu; Zhang, Wei; Zhou, Lingjun; Keefe, David L; Liu, Lin
2009 Jun 15;18(12):2177-2187, Human molecular genetics
— id: 101970, year: 2009, vol: 18, page: 2177, stat: Journal Article,

Physician referral for fertility preservation in oncology patients: a national study of practice behaviors
Quinn, Gwendolyn P; Vadaparampil, Susan T; Lee, Ji-Hyun; Jacobsen, Paul B; Bepler, Gerold; Lancaster, Johnathan; Keefe, David L; Albrecht, Terrance L
2009 Dec 10;27(35):5952-5957, Journal of clinical oncology
— id: 144119, year: 2009, vol: 27, page: 5952, stat: Journal Article,

Trace element concentrations in follicular fluid of small follicles differ from those in blood serum, and may represent long-term exposure
Silberstein, Tali; Saphier, Oshra; Paz-Tal, Ofra; Gonzalez, Liliana; Keefe, David L; Trimarchi, James R
2009 May;91(5):1771-1774, Fertility & sterility
— id: 101974, year: 2009, vol: 91, page: 1771, stat: Journal Article,

Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation
Huang, Junjiu; Deng, Kai; Wu, Haojia; Liu, Zhong; Chen, Zhisheng; Cao, Shanbo; Zhou, Lingjun; Ye, Xiaoying; Keefe, David L; Liu, Lin
2008 Jul;26(7):1883-1890, Stem cells
— id: 101973, year: 2008, vol: 26, page: 1883, stat: Journal Article,

Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes
Liu, Lin; Keefe, David L
2008 Jan;16(1):103-112, Reproductive biomedicine online
— id: 101975, year: 2008, vol: 16, page: 103, stat: Journal Article,

Telomeres and meiosis in health and disease
Keefe, D L
2007 Jan;64(2):115-116, Cellular & molecular life sciences: CMLS
— id: 101979, year: 2007, vol: 64, page: 115, stat: Journal Article,

Telomeres and aging-related meiotic dysfunction in women
Keefe, D L; Liu, L; Marquard, K
2007 Jan;64(2):139-143, Cellular & molecular life sciences: CMLS
— id: 101980, year: 2007, vol: 64, page: 139, stat: Journal Article,

Telomere lengthening early in development
Liu, Lin; Bailey, Susan M; Okuka, Maja; Munoz, Purificacion; Li, Chao; Zhou, Lingjun; Wu, Chao; Czerwiec, Eva; Sandler, Laurel; Seyfang, Andreas; Blasco, Maria A; Keefe, David L
2007 Dec;9(12):1436-1441, Nature cell biology
— id: 101976, year: 2007, vol: 9, page: 1436, stat: Journal Article,

Nuclear transfer methods to study aging
Liu, Lin; Keefe, David L
2007 ;371:191-207, Methods in molecular biology
— id: 101977, year: 2007, vol: 371, page: 191, stat: Journal Article,

Germline stem cells and neo-oogenesis in the adult human ovary
Liu, Yifei; Wu, Chao; Lyu, Qifeng; Yang, Dongzi; Albertini, David F; Keefe, David L; Liu, Lin
2007 Jun 1;306(1):112-120, Developmental biology (Orlando)
— id: 101978, year: 2007, vol: 306, page: 112, stat: Journal Article,

Fate of centrosomes following somatic cell nuclear transfer (SCNT) in bovine oocytes
Dai, Yunping; Wang, Lili; Wang, Haiping; Liu, Ying; Li, Ning; Lyu, Qifeng; Keefe, David L; Albertini, David F; Liu, Lin
2006 Jun;131(6):1051-1061, Reproduction
— id: 101983, year: 2006, vol: 131, page: 1051, stat: Journal Article,

The telomere theory of reproductive senescence in women
Keefe, David L; Marquard, Kerri; Liu, Lin
2006 Jun;18(3):280-285, Current opinion in obstetrics & gynecology
— id: 101982, year: 2006, vol: 18, page: 280, stat: Journal Article,

Arsenite induces aberrations in meiosis that can be prevented by coadministration of N-acetylcysteine in mice
Navarro, Paula A A S; Liu, Lin; Ferriani, Rui A; Keefe, David L
2006 Apr;85 Suppl 1:1187-1194, Fertility & sterility
— id: 101984, year: 2006, vol: 85 Suppl 1, page: 1187, stat: Journal Article,

Mullerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology
Silberstein, T; MacLaughlin, D T; Shai, I; Trimarchi, J R; Lambert-Messerlian, G; Seifer, D B; Keefe, D L; Blazar, A S
2006 Jan;21(1):159-163, Human reproduction
— id: 101988, year: 2006, vol: 21, page: 159, stat: Journal Article,

Lead concentrates in ovarian follicle compromises pregnancy
Silberstein, Tali; Saphier, Oshra; Paz-Tal, Ofra; Trimarchi, James R; Gonzalez, Liliana; Keefe, David L
2006 ;20(3):205-207, Journal of trace elements in medicine & biology
— id: 101981, year: 2006, vol: 20, page: 205, stat: Journal Article,

Assessing the quality of oocytes derived from in vitro maturation: are we looking under the lamppost?
Trimarchi, James Robert; Keefe, David L
2006 Apr;85(4):839-40; discussion 841, Fertility & sterility
— id: 101985, year: 2006, vol: 85, page: 839, stat: Journal Article,

Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women
Keefe, David L; Franco, Sonia; Liu, Lin; Trimarchi, James; Cao, Benning; Weitzen, Sherry; Agarwal, Shoba; Blasco, Maria A
2005 Apr;192(4):1256-60; discussion 1260, American journal of obstetrics & gynecology
— id: 101989, year: 2005, vol: 192, page: 1256, stat: Journal Article,

New approaches to assisted reproductive technologies
Keefe, David L; Parry, John P
2005 Nov;23(4):301-308, Seminars in reproductive medicine
— id: 101986, year: 2005, vol: 23, page: 301, stat: Journal Article,

Noninvasive imaging of spindle dynamics during mammalian oocyte activation
Navarro, Paula A A S; Liu, Lin; Trimarchi, James R; Ferriani, Rui A; Keefe, David L
2005 Apr;83 Suppl 1:1197-1205, Fertility & sterility
— id: 101990, year: 2005, vol: 83 Suppl 1, page: 1197, stat: Journal Article,

Pregnancy outcome in in vitro fertilization decreases to a plateau with repeated cycles
Silberstein, Tali; Trimarchi, James R; Gonzalez, Liliana; Keefe, David L; Blazar, Andrew S
2005 Oct;84(4):1043-1045, Fertility & sterility
— id: 101987, year: 2005, vol: 84, page: 1043, stat: Journal Article,

Responses to a saline load in gonadotropin-releasing hormone antagonist-pretreated premenopausal women receiving progesterone or estradiol-progesterone therapy
Stachenfeld, Nina S; Keefe, David L; Taylor, Hugh S
2005 Jan;90(1):386-394, Journal of clinical endocrinology & metabolism
— id: 101993, year: 2005, vol: 90, page: 386, stat: Journal Article,

Direct visual and circadian pathways target neuroendocrine cells in primates
Abizaid, Alfonso; Horvath, Balazs; Keefe, David L; Leranth, Csaba; Horvath, Tamas L
2004 Nov;20(10):2767-2776, European journal of neuroscience
— id: 101991, year: 2004, vol: 20, page: 2767, stat: Journal Article,

Serum estradiol positively predicts outcomes in patients undergoing in vitro fertilization
Blazar, Andrew S; Hogan, Joseph W; Frankfurter, David; Hackett, Richard; Keefe, David L
2004 Jun;81(6):1707-1709, Fertility & sterility
— id: 101996, year: 2004, vol: 81, page: 1707, stat: Journal Article,

Middle to lower uterine segment embryo transfer improves implantation and pregnancy rates compared with fundal embryo transfer
Frankfurter, David; Trimarchi, James B; Silva, Celso P; Keefe, David L
2004 May;81(5):1273-1277, Fertility & sterility
— id: 101998, year: 2004, vol: 81, page: 1273, stat: Journal Article,

Monozygotic pregnancies from transfers of zona-free blastocysts
Frankfurter, David; Trimarchi, James; Hackett, Rick; Meng, Li; Keefe, David
2004 Aug;82(2):483-485, Fertility & sterility
— id: 144321, year: 2004, vol: 82, page: 483, stat: Journal Article,

Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos
Liu, Lin; Czerwiec, Eva; Keefe, David L
2004 Jul;4(4):433-441, Gene expression patterns
— id: 101997, year: 2004, vol: 4, page: 433, stat: Journal Article,

Telomerase deficiency impairs differentiation of mesenchymal stem cells
Liu, Lin; DiGirolamo, Carla M; Navarro, Paula A A S; Blasco, Maria A; Keefe, David L
2004 Mar 10;294(1):1-8, Experimental cell research
— id: 102001, year: 2004, vol: 294, page: 1, stat: Journal Article,

Irregular telomeres impair meiotic synapsis and recombination in mice
Liu, Lin; Franco, Sonia; Spyropoulos, Barbara; Moens, Peter B; Blasco, Maria A; Keefe, David L
2004 Apr 27;101(17):6496-6501, Proceedings of the National Academy of Sciences of the United States of America
— id: 101999, year: 2004, vol: 101, page: 6496, stat: Journal Article,

Nuclear origin of aging-associated meiotic defects in senescence-accelerated mice
Liu, Lin; Keefe, David L
2004 Nov;71(5):1724-1729, Biology of reproduction
— id: 101994, year: 2004, vol: 71, page: 1724, stat: Journal Article,

In vivo effects of arsenite on meiosis, preimplantation development, and apoptosis in the mouse
Navarro, Paula A A S; Liu, Lin; Keefe, David L
2004 Apr;70(4):980-985, Biology of reproduction
— id: 102002, year: 2004, vol: 70, page: 980, stat: Journal Article,

Noninvasive polarized light microscopy quantitatively distinguishes the multilaminar structure of the zona pellucida of living human eggs and embryos
Pelletier, Cory; Keefe, David L; Trimarchi, James R
2004 Mar;81 Suppl 1:850-856, Fertility & sterility
— id: 102000, year: 2004, vol: 81 Suppl 1, page: 850, stat: Journal Article,

Cannulation of a resistant internal os with the malleable outer sheath of a coaxial soft embryo transfer catheter does not affect in vitro fertilization-embryo transfer outcome
Silberstein, Tali; Weitzen, Sherry; Frankfurter, David; Trimarchi, James R; Keefe, David L; Plosker, Shayne M
2004 Nov;82(5):1402-1406, Fertility & sterility
— id: 101992, year: 2004, vol: 82, page: 1402, stat: Journal Article,

Overheating is detrimental to meiotic spindles within in vitro matured human oocytes
Sun, Xiao-Fang; Wang, Wei-Hua; Keefe, David L
2004 Feb;12(1):65-70, Zygote
— id: 101995, year: 2004, vol: 12, page: 65, stat: Journal Article,

Improved endometrial assessment using cyclin E and p27
Dubowy, Rebecca L; Feinberg, Ronald F; Keefe, David L; Doncel, Gustavo F; Williams, Shaun C; McSweet, Juliette C; Kliman, Harvey J
2003 Jul;80(1):146-156, Fertility & sterility
— id: 102005, year: 2003, vol: 80, page: 146, stat: Journal Article,

The transfer point is a novel measure of embryo placement
Frankfurter, David; Silva, Celso P; Mota, Francisco; Trimarchi, James B; Keefe, David L
2003 Jun;79(6):1416-1421, Fertility & sterility
— id: 102006, year: 2003, vol: 79, page: 1416, stat: Journal Article,

Imaging meiotic spindles by polarization light microscopy: principles and applications to IVF
Keefe, David; Liu, Lin; Wang, Wei; Silva, Celso
2003 Jul-Aug;7(1):24-29, Reproductive biomedicine online
— id: 133648, year: 2003, vol: 7, page: 24, stat: Journal Article,

Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis
Liu, Lin; Trimarchi, James R; Navarro, Paula; Blasco, Maria A; Keefe, David L
2003 Aug 22;278(34):31998-32004, Journal of biological chemistry
— id: 102007, year: 2003, vol: 278, page: 31998, stat: Journal Article,

Control of ascorbic acid efflux in rat luteal cells: role of intracellular calcium and oxygen radicals
Pepperell, John R; Porterfield, D Marshall; Keefe, David L; Behrman, Harold R; Smith, Peter J S
2003 Sep;285(3):C642-C651, American journal of physiology. Cell physiology
— id: 102008, year: 2003, vol: 285, page: C642, stat: Journal Article,

Oestrogen effects on urine concentrating response in young women
Stachenfeld, Nina S; Taylor, Hugh S; Leone, Cheryl A; Keefe, David L
2003 Nov 1;552(Pt 3):869-880, Journal of physiology
— id: 102003, year: 2003, vol: 552, page: 869, stat: Journal Article,

Sex hormones and neural mechanisms
Keefe, David L
2002 Oct;31(5):401-403, Archives of sexual behaviour
— id: 102012, year: 2002, vol: 31, page: 401, stat: Journal Article,

Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles
Liu, Lin; Blasco, Maria A; Keefe, David L
2002 Mar;3(3):230-234, EMBO reports
— id: 102017, year: 2002, vol: 3, page: 230, stat: Journal Article,

An essential role for functional telomeres in mouse germ cells during fertilization and early development
Liu, Lin; Blasco, Maria; Trimarchi, James; Keefe, David
2002 Sep 1;249(1):74-84, Developmental biology (Orlando)
— id: 133649, year: 2002, vol: 249, page: 74, stat: Journal Article,

Ageing-associated aberration in meiosis of oocytes from senescence-accelerated mice
Liu, Lin; Keefe, David L
2002 Oct;17(10):2678-2685, Human reproduction
— id: 102011, year: 2002, vol: 17, page: 2678, stat: Journal Article,

Haploidy but not parthenogenetic activation leads to increased incidence of apoptosis in mouse embryos
Liu, Lin; Trimarchi, James R; Keefe, David L
2002 Jan;66(1):204-210, Biology of reproduction
— id: 102019, year: 2002, vol: 66, page: 204, stat: Journal Article,

Checkpoint for DNA integrity at the first mitosis after oocyte activation
Liu, Lin; Trimarchi, James R; Smith, Peter J S; Keefe, David L
2002 Jun;62(2):277-288, Molecular reproduction & development
— id: 102015, year: 2002, vol: 62, page: 277, stat: Journal Article,

Mitochondrial dysfunction leads to telomere attrition and genomic instability
Liu, Lin; Trimarchi, James R; Smith, Peter J S; Keefe, David L
2002 Oct;1(1):40-46, Aging cell
— id: 102004, year: 2002, vol: 1, page: 40, stat: Journal Article,

Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld, Nina S; Keefe, David L
2002 Oct;283(4):E711-E721, American journal of physiology. Endocrinology & metabolism
— id: 102013, year: 2002, vol: 283, page: E711, stat: Journal Article,

Safe and cost effective use of alteplase for the clearance of occluded central venous access devices
Timoney, J P; Malkin, M G; Leone, D M; Groeger, J S; Heaney, M L; Keefe, D L; Klang, M; Lucarelli, C D; Muller, R J; Eng, S L; Connor, M; Small, T N; Brown, A E; Saltz, L B
2002 Apr 1;20(7):1918-1922, Journal of clinical oncology
— id: 102016, year: 2002, vol: 20, page: 1918, stat: Journal Article,

Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation
Trimarchi, James R; Liu, Lin; Smith, Peter J S; Keefe, David L
2002 Mar;282(3):C588-C594, American journal of physiology. Cell physiology
— id: 102018, year: 2002, vol: 282, page: C588, stat: Journal Article,

Prediction of chromosome misalignment among in vitro matured human oocytes by spindle imaging with the PolScope
Wang, Wei Hua; Keefe, David L
2002 Nov;78(5):1077-1081, Fertility & sterility
— id: 102009, year: 2002, vol: 78, page: 1077, stat: Journal Article,

Spindle observation in living mammalian oocytes with the polarization microscope and its practical use
Wang, Wei-Hua; Keefe, David L
2002 ;4(3):269-276, Cloning & stem cells
— id: 102010, year: 2002, vol: 4, page: 269, stat: Journal Article,

Rigorous thermal control during intracytoplasmic sperm injection stabilizes the meiotic spindle and improves fertilization and pregnancy rates
Wang, Wei-Hua; Meng, Li; Hackett, Richard J; Oldenbourg, Rudolf; Keefe, David L
2002 Jun;77(6):1274-1277, Fertility & sterility
— id: 102014, year: 2002, vol: 77, page: 1274, stat: Journal Article,

Circulatory shock
Bogolioubov, A; Keefe, D L; Groeger, J S
2001 Jul;17(3):697-719, Critical care clinics
— id: 102026, year: 2001, vol: 17, page: 697, stat: Journal Article,

Progesterone does not alter osmotic regulation of AVP
Calzone, W L; Silva, C; Keefe, D L; Stachenfeld, N S
2001 Dec;281(6):R2011-R2020, American journal of physiology. Regulatory, integrative, & comparative physiology
— id: 102021, year: 2001, vol: 281, page: R2011, stat: Journal Article,

Anthracycline-induced cardiomyopathy
Keefe, D L
2001 Aug;28(4 Suppl 12):2-7, Seminars in oncology
— id: 102025, year: 2001, vol: 28, page: 2, stat: Journal Article,

Mitochondrial modulation of calcium signaling at the initiation of development
Liu, L; Hammar, K; Smith, P J; Inoue, S; Keefe, D L
2001 Dec;30(6):423-433, Cell calcium
— id: 102020, year: 2001, vol: 30, page: 423, stat: Journal Article,

Estrogen and progesterone effects on transcapillary fluid dynamics
Stachenfeld, N S; Keefe, D L; Palter, S F
2001 Oct;281(4):R1319-R1329, American journal of physiology. Regulatory, integrative, & comparative physiology
— id: 102024, year: 2001, vol: 281, page: R1319, stat: Journal Article,

Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld, N S; Splenser, A E; Calzone, W L; Taylor, M P; Keefe, D L
2001 Oct;91(4):1893-1901, Journal of applied physiology (Bethesda)
— id: 102023, year: 2001, vol: 91, page: 1893, stat: Journal Article,

Developmental ability of human oocytes with or without birefringent spindles imaged by Polscope before insemination
Wang, W H; Meng, L; Hackett, R J; Keefe, D L
2001 Jul;16(7):1464-1468, Human reproduction
— id: 102027, year: 2001, vol: 16, page: 1464, stat: Journal Article,

Limited recovery of meiotic spindles in living human oocytes after cooling-rewarming observed using polarized light microscopy
Wang, W H; Meng, L; Hackett, R J; Odenbourg, R; Keefe, D L
2001 Nov;16(11):2374-2378, Human reproduction
— id: 102022, year: 2001, vol: 16, page: 2374, stat: Journal Article,

The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes
Wang, W H; Meng, L; Hackett, R J; Odenbourg, R; Keefe, D L
2001 Feb;75(2):348-353, Fertility & sterility
— id: 102029, year: 2001, vol: 75, page: 348, stat: Journal Article,

Bioavailability and bioequivalence: average, population and/or individual
Colburn, W A; Keefe, D L
2000 Jun;40(6):559-560, Journal of clinical pharmacology
— id: 102031, year: 2000, vol: 40, page: 559, stat: Journal Article,

Cardiovascular emergencies in the cancer patient
Keefe, D L
2000 Jun;27(3):244-255, Seminars in oncology
— id: 102032, year: 2000, vol: 27, page: 244, stat: Journal Article,

Clinical pharmacology of telmisartan:
Keefe, D L
2000 Dec;40(12 Pt 1):1311-1311, Journal of clinical pharmacology
— id: 102028, year: 2000, vol: 40, page: 1311, stat: Journal Article,

Cytoplasm mediates both development and oxidation-induced apoptotic cell death in mouse zygotes
Liu, L; Keefe, D L
2000 Jun;62(6):1828-1834, Biology of reproduction
— id: 102036, year: 2000, vol: 62, page: 1828, stat: Journal Article,

A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes
Liu, L; Oldenbourg, R; Trimarchi, J R; Keefe, D L
2000 Feb;18(2):223-225, Nature biotechnology
— id: 102039, year: 2000, vol: 18, page: 223, stat: Journal Article,

Involvement of mitochondria in oxidative stress-induced cell death in mouse zygotes
Liu, L; Trimarchi, J R; Keefe, D L
2000 Jun;62(6):1745-1753, Biology of reproduction
— id: 102037, year: 2000, vol: 62, page: 1745, stat: Journal Article,

Increased birefringence in the meiotic spindle provides a new marker for the onset of activation in living oocytes
Liu, L; Trimarchi, J R; Oldenbourg, R; Keefe, D L
2000 Jul;63(1):251-258, Biology of reproduction
— id: 102033, year: 2000, vol: 63, page: 251, stat: Journal Article,

Acute bacterial endocarditis during granulocytopenia in an allogenic marrow transplant recipient
Safdar, A; Childs, B H; Keefe, D; Sepkowitz, K A
2000 Oct;109(6):514-515, American journal of medicine
— id: 174323, year: 2000, vol: 109, page: 514, stat: Journal Article,

Estrogen modifies the temperature effects of progesterone
Stachenfeld, N S; Silva, C; Keefe, D L
2000 May;88(5):1643-1649, Journal of applied physiology (Bethesda)
— id: 102038, year: 2000, vol: 88, page: 1643, stat: Journal Article,

A non-invasive method for measuring preimplantation embryo physiology
Trimarchi, J R; Liu, L; Porterfield, D M; Smith, P J; Keefe, D L
2000 Feb;8(1):15-24, Zygote
— id: 102034, year: 2000, vol: 8, page: 15, stat: Journal Article,

Oxidative phosphorylation-dependent and -independent oxygen consumption by individual preimplantation mouse embryos
Trimarchi, J R; Liu, L; Porterfield, D M; Smith, P J; Keefe, D L
2000 Jun;62(6):1866-1874, Biology of reproduction
— id: 102035, year: 2000, vol: 62, page: 1866, stat: Journal Article,

Noninvasive measurement of potassium efflux as an early indicator of cell death in mouse embryos
Trimarchi, J R; Liu, L; Smith, P J; Keefe, D L
2000 Sep;63(3):851-857, Biology of reproduction
— id: 102030, year: 2000, vol: 63, page: 851, stat: Journal Article,

Hormone replacement therapy may alleviate sleep apnea in menopausal women: a pilot study
Keefe, D L; Watson, R; Naftolin, F
1999 Fall;6(3):196-200, Menopause
— id: 102041, year: 1999, vol: 6, page: 196, stat: Journal Article,

Thiol oxidation-induced embryonic cell death in mice is prevented by the antioxidant dithiothreitol
Liu, L; Trimarchi, J R; Keefe, D L
1999 Oct;61(4):1162-1169, Biology of reproduction
— id: 102040, year: 1999, vol: 61, page: 1162, stat: Journal Article,

Transmembrane regulation of intracellular calcium by a plasma membrane sodium/calcium exchanger in mouse ova
Pepperell, J R; Kommineni, K; Buradagunta, S; Smith, P J; Keefe, D L
1999 May;60(5):1137-1143, Biology of reproduction
— id: 102044, year: 1999, vol: 60, page: 1137, stat: Journal Article,

Microinjection of mitochondria into zygotes creates a model for studying the inheritance of mitochondrial DNA during preimplantation development
Rinaudo, P; Niven-Fairchild, T; Buradagunta, S; Massobrio, M; Revelli, A; Keefe, D L
1999 May;71(5):912-918, Fertility & sterility
— id: 102043, year: 1999, vol: 71, page: 912, stat: Journal Article,

The first polar body does not predict accurately the location of the metaphase II meiotic spindle in mammalian oocytes
Silva, C P; Kommineni, K; Oldenbourg, R; Keefe, D L
1999 Apr;71(4):719-721, Fertility & sterility
— id: 102045, year: 1999, vol: 71, page: 719, stat: Journal Article,

Physiological variability of fluid-regulation hormones in young women
Stachenfeld, N S; DiPietro, L; Kokoszka, C A; Silva, C; Keefe, D L; Nadel, E R
1999 Mar;86(3):1092-1096, Journal of applied physiology (Bethesda)
— id: 102046, year: 1999, vol: 86, page: 1092, stat: Journal Article,

Effects of oral contraceptives on body fluid regulation
Stachenfeld, N S; Silva, C; Keefe, D L; Kokoszka, C A; Nadel, E R
1999 Sep;87(3):1016-1025, Journal of applied physiology (Bethesda)
— id: 102042, year: 1999, vol: 87, page: 1016, stat: Journal Article,

Do attitudes toward disclosure in donor oocyte recipients predict the use of anonymous versus directed donation?
Greenfeld, D A; Greenfeld, D G; Mazure, C M; Keefe, D L; Olive, D L
1998 Dec;70(6):1009-1014, Fertility & sterility
— id: 102047, year: 1998, vol: 70, page: 1009, stat: Journal Article,

Lack of increased cardiac toxicity with sequential doxorubicin and paclitaxel
Hudis C; Riccio L; Seidman A; Baselga J; Currie V; Fennelly D; Gilewski T; Lebwohl D; Moynahan M; Raptis G; Surbone A; Sklarin N; Yao TJ; Keefe D; Norton L
1998 ;16(2):67-71, Cancer investigation
— id: 38037, year: 1998, vol: 16, page: 67, stat: Journal Article,

Reproductive aging is an evolutionarily programmed strategy that no longer provides adaptive value
Keefe, D L
1998 Aug;70(2):204-206, Fertility & sterility
— id: 102049, year: 1998, vol: 70, page: 204, stat: Journal Article,

Characterization of oxygen and calcium fluxes from early mouse embryos and oocytes
Porterfield, D M; Trimarchi, J R; Keefe, D L; Smith, P J
1998 Oct;195(2):208-209, Biological bulletin
— id: 102048, year: 1998, vol: 195, page: 208, stat: Journal Article,

Aging and infertility in women
Keefe, D L
1997 Dec;80(12):403-405, Medicine & health, Rhode Island
— id: 102050, year: 1997, vol: 80, page: 403, stat: Journal Article,

Dissociation between intracellular calcium elevation and development of human oocytes treated with calcium ionophore
Rinaudo, P; Pepperell, J R; Buradgunta, S; Massobrio, M; Keefe, D L
1997 Dec;68(6):1086-1092, Fertility & sterility
— id: 102051, year: 1997, vol: 68, page: 1086, stat: Journal Article,

Who is responsible for clinical pharmacology?
Colburn, W A; Keefe, D L
1996 May;36(5):383-385, Journal of clinical pharmacology
— id: 102054, year: 1996, vol: 36, page: 383, stat: Journal Article,

Transvaginal uterine cervical dilation with fluoroscopic guidance: preliminary results in patients with infertility
Dickey, K W; Zreik, T G; Hsia, H C; Eschelman, D J; Keefe, D L; Olive, D L; Pollak, J S; Rosenblatt, M; Glickman, M G
1996 Aug;200(2):497-503, Radiology
— id: 102053, year: 1996, vol: 200, page: 497, stat: Journal Article,

Dependency on progesterone in woman with self-diagnosed premenstrual syndrome
Keefe, D L; Sarrel, P
1996 Apr 27;347(9009):1182-1182, Lancet
— id: 102055, year: 1996, vol: 347, page: 1182, stat: Journal Article,

Fluoroscopically Guided Cervical Dilatation in Patients with Infertility
Zreik TG; Dickey KW; Keefe DL; Glickman MG; Olive DL
1996 Aug;3(4, Supplement):S56-S56, Journal of the American Association of Gynecologic Laparoscopists
— id: 102052, year: 1996, vol: 3, page: S56, stat: Journal Article,

Similarities and differences between anonymous and directed candidates for oocyte donation
Greenfeld, D A; Mazure, C M; Olive, D L; Keefe, D L
1995 Feb;12(2):118-122, Journal of assisted reproduction & genetics
— id: 102057, year: 1995, vol: 12, page: 118, stat: Journal Article,

Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women
Keefe, D L; Niven-Fairchild, T; Powell, S; Buradagunta, S
1995 Sep;64(3):577-583, Fertility & sterility
— id: 102056, year: 1995, vol: 64, page: 577, stat: Journal Article,

Estrogen mustard induces cell cycle arrest of human epithelial ovarian cancer cell lines
Nathan, J D; Keefe, D L; Weinstein, M A; Chen, Z; Naftolin, F
1994 Jan-Mar;1(1):97-103, Journal of the Society for Gynecologic Investigation
— id: 102058, year: 1994, vol: 1, page: 97, stat: Journal Article,

1994 ;1(2):83-90, Menopause
— id: 103013, year: 1994, vol: 1, page: 83, stat: Journal Article,

Neuron-glial Interactions In The Estrogen-sensitive Zone Of Reaction Of The Rat Hypothalamus
Keefe, DL; Moore, TC; Stein, M; Naftolin, F
Local systems in reproduction New York : Raven Press, 1993,
— id: 5188, year: 1993, vol: , page: 33, stat: Chapter,

Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells
Piepmeier, J M; Keefe, D L; Weinstein, M A; Yoshida, D; Zielinski, J; Lin, T T; Chen, Z; Naftolin, F
1993 Mar;32(3):422-30; discussion 430, Neurosurgery
— id: 102059, year: 1993, vol: 32, page: 422, stat: Journal Article,

Quantification of hormone pulsatility via an approximate entropy algorithm
Pincus, S M; Keefe, D L
1992 May;262(5 Pt 1):E741-E754, American journal of physiology
— id: 102061, year: 1992, vol: 262, page: E741, stat: Journal Article,

Estrogen-effects On The Organization Of The Rat Brain Astrocytes Within The Hypothalamic Arcuate Nucleus Contain Estrogen-sensitive Peroxidase Activity And May Mediate Synaptic Plasticity In The Rat
Keefe DL; Michelson DS; Naftolin F
The new biology of steroid hormones New York : Raven Press, 1991,
— id: 5820, year: 1991, vol: , page: 265, stat: Chapter,

Astrocytes within the hypothalamic arcuate nucleus contain estrogen-sensitive peroxidase, bind fluorescein-conjugated estradiol, and may mediate synaptic plasticity in the rat
Keefe, D L; Michelson, D S; Lee, S H; Naftolin, F
1991 Apr;164(4):959-966, American journal of obstetrics & gynecology
— id: 102063, year: 1991, vol: 164, page: 959, stat: Journal Article,

A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster
Keefe, D L; Earnest, D J; Nelson, D; Takahashi, J S; Turek, F W
1987 Feb 17;403(2):308-312, Brain research
— id: 102064, year: 1987, vol: 403, page: 308, stat: Journal Article,

Circadian time keeping processes in mammalian reproduction
Keefe, D L; Turek, F W
1985 ;7:346-400, Oxford reviews of reproductive biology
— id: 102066, year: 1985, vol: 7, page: 346, stat: Journal Article,