Brian S Kaufman, M.D.

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer
Maxwell, Christopher A; Benitez, Javier; Gomez-Baldo, Laia; Osorio, Ana; Bonifaci, Nuria; Fernandez-Ramires, Ricardo; Costes, Sylvain V; Guino, Elisabet; Chen, Helen; Evans, Gareth J R; Mohan, Pooja; Catala, Isabel; Petit, Anna; Aguilar, Helena; Villanueva, Alberto; Aytes, Alvaro; Serra-Musach, Jordi; Rennert, Gad; Lejbkowicz, Flavio; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Ripamonti, Carla B; Bonanni, Bernardo; Viel, Alessandra; Allavena, Anna; Bernard, Loris; Radice, Paolo; Friedman, Eitan; Kaufman, Bella; Laitman, Yael; Dubrovsky, Maya; Milgrom, Roni; Jakubowska, Anna; Cybulski, Cezary; Gorski, Bohdan; Jaworska, Katarzyna; Durda, Katarzyna; Sukiennicki, Grzegorz; Lubinski, Jan; Shugart, Yin Yao; Domchek, Susan M; Letrero, Richard; Weber, Barbara L; Hogervorst, Frans B L; Rookus, Matti A; Collee, J Margriet; Devilee, Peter; Ligtenberg, Marjolijn J; Luijt, Rob B van der; Aalfs, Cora M; Waisfisz, Quinten; Wijnen, Juul; Roozendaal, Cornelis E P van; Easton, Douglas F; Peock, Susan; Cook, Margaret; Oliver, Clare; Frost, Debra; Harrington, Patricia; Evans, D Gareth; Lalloo, Fiona; Eeles, Rosalind; Izatt, Louise; Chu, Carol; Eccles, Diana; Douglas, Fiona; Brewer, Carole; Nevanlinna, Heli; Heikkinen, Tuomas; Couch, Fergus J; Lindor, Noralane M; Wang, Xianshu; Godwin, Andrew K; Caligo, Maria A; Lombardi, Grazia; Loman, Niklas; Karlsson, Per; Ehrencrona, Hans; Wachenfeldt, Anna von; Barkardottir, Rosa Bjork; Hamann, Ute; Rashid, Muhammad U; Lasa, Adriana; Caldes, Trinidad; Andres, Raquel; Schmitt, Michael; Assmann, Volker; Stevens, Kristen; Offit, Kenneth; Curado, Joao; Tilgner, Hagen; Guigo, Roderic; Aiza, Gemma; Brunet, Joan; Castellsague, Joan; Martrat, Griselda; Urruticoechea, Ander; Blanco, Ignacio; Tihomirova, Laima; Goldgar, David E; Buys, Saundra; John, Esther M; Miron, Alexander; Southey, Melissa; Daly, Mary B; Schmutzler, Rita K; Wappenschmidt, Barbara; Meindl, Alfons; Arnold, Norbert; Deissler, Helmut; Varon-Mateeva, Raymonda; Sutter, Christian; Niederacher, Dieter; Imyamitov, Evgeny; Sinilnikova, Olga M; Stoppa-Lyonne, Dominique; Mazoyer, Sylvie; Verny-Pierre, Carole; Castera, Laurent; de Pauw, Antoine; Bignon, Yves-Jean; Uhrhammer, Nancy; Peyrat, Jean-Philippe; Vennin, Philippe; Fert Ferrer, Sandra; Collonge-Rame, Marie-Agnes; Mortemousque, Isabelle; Spurdle, Amanda B; Beesley, Jonathan; Chen, Xiaoqing; Healey, Sue; Barcellos-Hoff, Mary Helen; Vidal, Marc; Gruber, Stephen B; Lazaro, Conxi; Capella, Gabriel; McGuffog, Lesley; Nathanson, Katherine L; Antoniou, Antonis C; Chenevix-Trench, Georgia; Fleisch, Markus C; Moreno, Victor; Pujana, Miguel Angel
2011 Nov;9(11):e1001199-e1001199, PLoS biology
Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM
— id: 150852, year: 2011, vol: 9, page: e1001199, stat: Journal Article,

High-fidelity simulation to evaluate professionalism in critical care
Taparia V.; Felner K.; Kaufman B.
2011 ;140(4):?-?, Chest
PURPOSE: Current methods of measuring medical professionalism are subjective. They often do not account for high-pressure environments where professionalism can be strained, such as the intensive care unit (ICU). High-fidelity simulation (HFS) is a technology in which standardized, high-pressure patient scenarios are practiced. The standardization of HFS allows for objective measurement of professionalism-specific behaviors found in the ICU. METHODS: Forty-four second-year internal medicine residents underwent HFS of a critically-ill patient. Professionalism-specific behaviors pertaining to obtaining informed consent for central venous line (CVL) placement and disclosure of an iatrogenic complication secondary to the CVL were evaluated. A comprehensive checklist itemized pre-determined professionalism-specific behaviors as having been 'well done, ' 'partially done, ' or 'not done. ' The checklist was formulated from expert consultation, and items included objectively defined behaviors and excluded medical knowledge prerequisites. Video-recordings of simulations were reviewed by three independent raters, each of which underwent training prior to project initiation. RESULTS: Composite scores from three raters revealed that 74.2% (98/132) and 67.4% (89/132) of residents received 'well done ' scores for discussion of CVL benefits and risks, respectively. Sixteen percent (21/132) of residents received 'well done ' scores regarding discussion of alternatives to CVL placement. Concerning disclosure of the iatrogenic complication, 22% (29/132) of residents performed this task well. Cronbach's alpha analyses of internal consistency were .813 for obtaining informed consent and .709 for disclosure of the iatrogenic complication. CONCLUSIONS: During our ICU simulation, a majority of residents outlined benefits and risks to CVL placement well, though most neglected to discuss alternatives. Furthermore, a minority of residents disclosed the etiology of the iatrogenic complication. It is possible that the high-stress simulated ICU environment contributed to the low prevalence of these behaviors. CLINICAL IMPLICATIONS: Objective tools to evaluate medical professionalism are scarce. However, our assessment tool checklist demonstrates good internal consistency, and therefore HFS of a critically-ill patient can be used to reliably and objectively measure pre-determined professionalism-specific behaviors
— id: 149975, year: 2011, vol: 140, page: ?, stat: Journal Article,

Inhalational anesthetics
Kaufman, Brian; Griffel, Martin
Goldfrank's toxicologic emergencies New York : McGraw-Hill, 2006,
— id: 4560, year: 2006, vol: , page: 1016, stat: Chapter,

Dexmedetomidine facilitates withdrawal of ventilatory support
Kent CD; Kaufman BS; Lowy J
2006 Apr;104(4):890-890, Anesthesiology
— id: 63730, year: 2006, vol: 104, page: 890, stat: Journal Article,

Local anesthetics
Schwartz, David R; Kaufman, Brian
Goldfrank's toxicologic emergencies New York : McGraw-Hill, 2006,
— id: 4564, year: 2006, vol: , page: 1004, stat: Chapter,

Antidotes in depth : Dantrolene sodium
Sutin, Kenneth M; Kaufman, Brian; Miller, Sanford M
Goldfrank's toxicologic emergencies New York : McGraw-Hill, 2006,
— id: 4566, year: 2006, vol: , page: 1037, stat: Chapter,

Neuromuscular blockers
Sutin, Kenneth M; Kaufman, Brian; Miller, Sanford M
Goldfrank's toxicologic emergencies New York : McGraw-Hill, 2006,
— id: 4565, year: 2006, vol: , page: 1024, stat: Chapter,

Dexmedetomidine facilitates the withdrawal of ventilatory support in palliative care
Kent, Christopher D; Kaufman, Brian S; Lowy, Joseph
2005 Aug;103(2):439-441, Anesthesiology
— id: 57845, year: 2005, vol: 103, page: 439, stat: Journal Article,

Inhalation anesthetics
Kaufman B
Goldfrank's toxiicological emergencies New York : McGraw Hill, 2002,
— id: 3356, year: 2002, vol: , page: ?, stat: Chapter,

Care of the poisoned patient
Kaufman B; Hoffman RS
Critical care medicine: perioperative management Philadelphia : Lippincott Williams & Wilkins, 2002,
— id: 3357, year: 2002, vol: , page: ?, stat: Chapter,

Local anesthetics
Kaufman B; Wahlander S
Goldfrank's toxiicological emergencies New York : McGraw Hill, 2002,
— id: 3355, year: 2002, vol: , page: ?, stat: Chapter,

Neuromuscular blocking agents
Sutin KM; Kaufman B
Goldfrank's toxicologic emergencies New York : McGraw-Hill, 2002,
— id: 2784, year: 2002, vol: , page: 253, stat: Chapter,

The use of dexmedetomidine infusion for awake craniotomy
Bekker AY; Kaufman B; Samir H; Doyle W
2001 May;92(5):1251-1253, Anesthesia & analgesia
— id: 20704, year: 2001, vol: 92, page: 1251, stat: Journal Article,

Chest radiograph interpretation skills of anesthesiologists
Kaufman B; Dhar P; O'Neill DK; Leitman B; Fermon CM; Wahlander SB; Sutin KM
2001 Dec;15(6):680-683, Journal of cardiothoracic & vascular anesthesia
OBJECTIVE: To assess the skills of anesthesiologists in the interpretation of chest radiographs. DESIGN: Randomized evaluation conducted among anesthesiologists and radiologists. SETTING: Postgraduate Assembly of the New York State Society of Anesthesiologists in 1999, and the Department of Radiology, New York University Medical Center. PARTICIPANTS: A total of 61 anesthesiologists (48 attending physicians; 13 residents); control group of 8 radiology residents (all participants volunteered). INTERVENTIONS: After completing a demographic survey, participants were asked to review a series of 10 chest radiographs. A brief clinical scenario accompanied each radiograph. No time limit was set for these interpretations. Measurements and Main Results: The demographic characteristics of the anesthesiology participants included university faculty (46%), private group practitioners (41%), independent practitioners (11%), and 1 participant with an unspecified type of practice. Additional training among the participants included internal medicine (31%), surgery (19%), and pediatrics (3%); 34% did not specify any additional training. Of the participants, 92% were involved in cases requiring general anesthesia; 96% managed patients in the recovery room; and 34% managed patients in the intensive care unit. Of participants, 80% usually order chest radiographs, but only 42% interpret the films themselves. Misdiagnosed radiographs included pneumothorax by 11% of participants, free air under the diaphragm by 41%, bronchial perforation from a nasogastric tube by 28%, right mainstem intubation by 20%, superior vena cava perforation from a central venous catheter by 31%, normal film by 75%, negative pressure pulmonary edema by 16%, left lower lobe collapse by 80%, pulmonary infarction from a pulmonary artery catheter by 29%, and tension pneumothorax by 41%. Overall scores of the attending physicians were not significantly different from that of residents (p > 0.05). The control group of radiology residents scored significantly better (mean, 83.7; p = 0.009) than the anesthesia residents (mean, 62.8) and anesthesia attending physicians (mean, 62.5). CONCLUSION: Anesthesiologists are deficient in skills for the interpretation of chest radiographs. The skill level of university-based physicians is not greater than physicians in private practice, and skill level does not improve with level of training or experience. Most anesthesiologists rely on radiologists for interpretative results. Further training during the residency years may help improve diagnostic skills
— id: 26533, year: 2001, vol: 15, page: 680, stat: Journal Article,

Chest radiograph interpretation skills among anesthesiologists
Dhar, P; Kaufman, B; Fermon, C; O'Neill, D; Sutin, K; Wahlander, S; Turndorf, H
2000 SEP ;70(4):U14-U14, Anesthesiology
— id: 54498, year: 2000, vol: 70, page: U14, stat: Journal Article,

Acute respiratory distress syndrome: Potential pharmacologic interventions
Kaufman B; Dhar P
1999 ;11(6):466-485, Journal of pharmacy practice
The mortality of the acute respiratory distress syndrome (ARDS) remains high despite advances in supportive care of ARDS and in the understanding of the pathogenesis. Numerous inflammatory mediators including reactive oxygen species, arachidonic acid metabolites, and growth factors, are present in the circulation of patients with or at risk for developing this syndrome and play a key pathophysiologic role in the development of lung injury. Pharmacologic therapy is being evaluated to: 1) support the failing lung by improving gas exchange; 2) interrupt the mediator-induced mechanisms of inflammation and injury. Although none of these experimental therapies has yet been proven to improve survival in well conducted prospective, randomized, double-blind, controlled clinical trials, many have demonstrated improvement in physiologic function. These results have helped lay the groundwork for future advances in this field
— id: 15961, year: 1999, vol: 11, page: 466, stat: Journal Article,

Unusual course of a pulmonary artery catheter
Dhar P; Kaufman B; Doerfler M; Dadic P
1998 Aug;12(4):487-489, Journal of cardiothoracic & vascular anesthesia
— id: 7549, year: 1998, vol: 12, page: 487, stat: Journal Article,

Anesthetics and neuromuscular blocking agents
Kaufman B; Sutin KM; Wahlander S; Miller SM
Goldfrank's Toxicologic emergencies Stamford, CT: Appleton & Lange, 1998,
— id: 2640, year: 1998, vol: , page: 873, stat: Chapter,

Blood lactate measurement in the ICU: Is it still useful after all these years?
Kaufman, B
1998 SEP-OCT ;13(5):215-217, Journal of intensive care medicine
— id: 53381, year: 1998, vol: 13, page: 215, stat: Journal Article,

Herpes simplex virus hepatitis: case report and review [see comments]
Kaufman B; Gandhi SA; Louie E; Rizzi R; Illei P
1997 Mar;24(3):334-338, Clinical infectious diseases
Hepatitis is an unusual manifestation of herpesvirus infection. Herpes simplex virus hepatitis is a difficult diagnosis to establish, and the infection is often fatal. We report one case of herpes simplex virus hepatitis and review 51 cases in the literature. Impaired immunity resulting from pregnancy, malignancy, immunosuppression, or inhalational anesthetics may be predisposing factors. Fever, nausea, vomiting, abdominal pain, leukopenia, thrombocytopenia, coagulopathy, and a marked rise in serum transaminase levels are invariably present. Liver biopsy is the procedure of choice for diagnosis. The liver appears mottled and has a minimal inflammatory response. Mortality rates associated with herpes simplex virus hepatitis are high, and early diagnosis and treatment with acyclovir or vidarabine may produce a favorable outcome
— id: 7177, year: 1997, vol: 24, page: 334, stat: Journal Article,

PACU and ICU: evaluation and management of postoperative cardiovascular complications
Kaufman BS; Weitz S
1997 ;15:189-205, Anesthesiology clinics of North America
— id: 45599, year: 1997, vol: 15, page: 189, stat: Journal Article,

Central venous catheter placement in patients with disorders of hemostasis
Doerfler ME; Kaufman B; Goldenberg AS
1996 Jul;110(1):185-188, Chest
OBJECTIVE: To define the incidence of bleeding complications from central venous access procedures performed by a critical care service in patients with disorders of hemostasis. DESIGN: Prospective, consecutive sample, collection of clinical data. SETTING: University teaching hospital. PATIENTS: Seventy-six consecutive patients with disorders of hemostasis who required central venous access for clinical management between October 1992 and October 1993. MEASUREMENTS: Age, sex, clinical diagnosis, most recent platelet count, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were recorded from the medical record of patients with known coagulation or platelet abnormalities. The site of central venous catheter placement, the number of needle passes necessary to complete the procedure, and the occurrence of complications were reported by the critical care attending physician performing or supervising the procedure. RESULTS: One hundred four central venous access procedures were performed on 76 patients with disorders of hemostasis. Seventy-three percent of catheters were placed in patients with platelet counts less than 100,000/mL and 40% of catheters were placed in patients with abnormalities of PT, aPTT, or both. Thirteen percent of patients had abnormalities of both platelets and coagulation profile. There were no serious complications. Bleeding complicated 7 (6.5% of the procedures; 5 patients had bleeding from the skin (from the suture sites in four), and 2 patients developed small periosteal hematomas. All patients with bleeding complications had thrombocytopenia with mean platelet counts of 22,000/mL and a range of 6,000 to 37,000/mL. Most patients with platelet counts in this range did not have clinically evident bleeding. CONCLUSIONS: Central venous access procedures can be done safely in patients with disorders of hemostasis by skilled physicians who frequently perform these procedures. Patients most likely to experience bleeding from these procedures are patients with severe thrombocytopenia. In this series, only a single patient, with a platelet count of 6,000/mL, required therapeutic blood product administration
— id: 6991, year: 1996, vol: 110, page: 185, stat: Journal Article,

Neuroleptic malignant syndrome postoperative onset due to levodopa withdrawal
Young CC; Kaufman BS
1995 Dec;7(8):652-656, Journal of clinical anesthesia
Neuroleptic malignant syndrome is a potentially fatal disorder that may develop in the perioperative period. A case is described in which discontinuation of chronic levodopa therapy precipitated the postoperative development of this syndrome. The differential diagnosis and management principles are reviewed
— id: 57387, year: 1995, vol: 7, page: 652, stat: Journal Article,

Central venous catheterization through guidewire exchange: are post-procedure chest radiographs necessary?
Kaufman B; Doerfler M
1994 ;22:A104-A104, Critical care medicine
— id: 47268, year: 1994, vol: 22, page: A104, stat: Journal Article,

Fluid resuscitation
Kaufman BS
Principles and practice of medical intensive care Philadelphia : Saunders, 1993,
— id: 3442, year: 1993, vol: , page: 129, stat: Chapter,

Pharmacology of colloids and crystalloids
Griffel, M I; Kaufman, B S
1992 Apr;8(2):235-253, Critical care clinics
We have attempted to review body fluid distribution by compartments so that the reader understands the physiology of ICF and ECF, and the relationship between interstitial and intravascular fluids. Crystalloids such as NS and RL are distributed to the ECF, whereas colloids primarily remain intravascular for longer periods. Although effective, crystalloids tend to require larger volumes for infusion, and edema remains a problem. Colloids as a group are extremely effective volume expanders, but none is ideal. Albumin, hetastarch, dextran, and the less commonly used colloids each have significant toxicities that must be considered when using them. Intelligent choices can be made to optimize use of these fluids
— id: 107899, year: 1992, vol: 8, page: 235, stat: Journal Article,

Fluid resuscitation in patients with increased vascular permeability
Haupt, M T; Kaufman, B S; Carlson, R W
1992 Apr;8(2):341-353, Critical care clinics
Fluid therapy is a uniformly accepted, logical, and highly effective therapeutic intervention for the treatment of patients with reductions in circulating intravascular volume. This article discusses fluid resuscitation of shock associated with increased vascular permeability and addresses the use of colloids and crystalloids in these disorders
— id: 107898, year: 1992, vol: 8, page: 341, stat: Journal Article,

Pitfalls of central hemodynamic monitoring
Kaufman BS
1992 ;38(10):27-31, Resident & staff physician
— id: 45941, year: 1992, vol: 38, page: 27, stat: Journal Article,

Deep vein thrombosis
Kaufman BS; Young CC
1992 ;10(4):823-867, Anesthesiology clinics of North America
— id: 45959, year: 1992, vol: 10, page: 823, stat: Journal Article,

Fluid resuscitation of the critically ill
Kaufman, Brian S
Philadelphia : Saunders, c1992,
— id: 393, year: 1992, vol: , page: , stat: ,

FLUID RESUSCITATION OF THE CRITICALLY ILL - PREFACE
KAUFMAN, BS
1992 APR ;8(2):R11-R11, Critical care clinics
— id: 52025, year: 1992, vol: 8, page: R11, stat: Journal Article,

Epidural anesthesia in the anticoagulated patient
Ruskin KJ; Kaufman BS
1992 ;19:25-26, Anesthesiology review
— id: 45942, year: 1992, vol: 19, page: 25, stat: Journal Article,

Intravenous fluid therapy in neurologic injury
Sutin KM; Ruskin KJ; Kaufman BS
1992 Apr;8(2):367-408, Critical care clinics
Cerebral autoregulation and the blood-brain barrier are two important mechanisms that attempt to preserve brain homeostasis. The function of either may be disrupted by injury. When autoregulation is impaired, blood pressure and hematocrit determine cerebral oxygen delivery. Injury to the blood-brain barrier impairs brain volume regulation and may contribute to cerebral edema. The choice of intravenous fluid influences cerebral blood flow, cerebral oxygen delivery, brain metabolism, and brain volume
— id: 13646, year: 1992, vol: 8, page: 367, stat: Journal Article,

Resolution of lactic acidosis after sedation of a patient with acute myocardial infarction and left ventricular failure
Kaufman BS; Griffel MI; Rackow EC; Weil MH
1991 Jan;19(1):120-122, Critical care medicine
— id: 14175, year: 1991, vol: 19, page: 120, stat: Journal Article,

Chronic mechanical ventilation
Meixler S; Kaufman B
Pulmonary therapy and rehabilitation : principles and practice Baltimore : Williams & Wilkins, 1991,
— id: 3458, year: 1991, vol: , page: 359, stat: Chapter,

Deep vein thrombosis and pulmonary embolism in the injured patient
Kaufman B
Trauma : anesthesia and intensive care Philadelphia : Lippincott, 1990,
— id: 3410, year: 1990, vol: , page: 821, stat: Chapter,

Fluid resuscitation of the critically ill: consensus and controversies
Kaufman B
1990 ;17(3S):2-2, Anesthesiology review
— id: 45966, year: 1990, vol: 17, page: 2, stat: Journal Article,

Infections of the injured
Kaufman B
Trauma : anesthesia and intensive care Philadelphia : Lippincott, 1990,
— id: 3411, year: 1990, vol: , page: 787, stat: Chapter,

Mangement of septic shock
Kaufman B
Trauma : anesthesia and intensive care Philadelphia : Lippincott, 1990,
— id: 3412, year: 1990, vol: , page: 801, stat: Chapter,

PREANESTHETIC ASSESSMENT OF THE PATIENT WITH RENAL-DISEASE
Kaufman, BS; Contreras, J
1990 Dec;8(4):677-695, Anesthesiology clinics of North America
— id: 31823, year: 1990, vol: 8, page: 677, stat: Journal Article,

Adrenal medullary transplants as a treatment for Parkinson's disease
Lieberman, A; Ransohoff, J; Berczeller, P; Brous, P; Eng, K; Goldstein, M; Kaufman, B; Koslow, M; Lieberman, I
1990 ;53:567-570, Advances in neurology
— id: 67625, year: 1990, vol: 53, page: 567, stat: Journal Article,

Anesthetic care of a patient with an intracranial hemorrhage after thrombolytic therapy
Lubarsky DA; Kaufman B; Turndorf H
1990 Jul-Aug;2(4):276-279, Journal of clinical anesthesia
Thrombolytic therapy is being used with increasing frequency to treat acute myocardial infarction (MI). It is important for both the general and cardiac anesthesiologist to understand the effects of thrombolysis on hemostasis and myocardial function, since these patients can present for emergent surgery in the cardiac or general operating theater. The authors report a case of a patient who developed an intracranial hemorrhage following thrombolytic therapy that required emergency surgical intervention
— id: 45793, year: 1990, vol: 2, page: 276, stat: Journal Article,

COMPLICATIONS ARISING FROM THE USE OF OPHTHALMOLOGIC MEDICATIONS IN AN INTENSIVE-CARE UNIT PATIENT
Herschman, Z; Kaufman, B
1989 Sep;89(9):537-538, New York state journal of medicine
— id: 31673, year: 1989, vol: 89, page: 537, stat: Journal Article,

DIFFERENTIAL-DIAGNOSIS OF WIDE QRS TACHYCARDIAS
HERSCHMAN, Z; KAUFMAN, B
1989 JUN ;7(2):351-372, Anesthesiology clinics of North America
— id: 51427, year: 1989, vol: 7, page: 351, stat: Journal Article,

Septic shock
Kaufman BS
1989 ;9:201-204, Current reviews in clinical anesthesia
— id: 45937, year: 1989, vol: 9, page: 201, stat: Journal Article,

MISINTERPRETATION OF LUNG PERFUSION SCAN - REPLY
Kaufman, B; Kutcher, W
1989 Jul;17(7):714-714, Critical care medicine
— id: 31682, year: 1989, vol: 17, page: 714, stat: Journal Article,

Adrenal medullary transplants as a treatment for advanced Parkinson's disease
Lieberman, A; Ransohoff, J; Berczeller, P; Brous, P; Eng, K; Goldstein, M; Kaufman, B; Koslow, M; Chin, L
1989 ;126:189-196, Acta neurologica Scandinavica. Supplementum
Open autologous adrenal medullary to caudate nucleus transplantation was performed in 12 patients with advanced Parkinson's disease (PD). Ten of these patients had diurnal response fluctuations including 'wearing off' and 'on/off' phenomena. All of the patients were no longer satisfactorily responding to levodopa/carbidopa and dopamine agonists. The mean age of the patients was 55.1 years (range 37-65 yrs); mean duration of PD was 11.7 years (range 4-40 yrs); mean stage 'on' was 3.3 (range 2-4); mean stage 'off' was 4.8 (range 4-5). Mean duration of follow up from surgery was 10.4 months (range 2-17 months). Three patients improved dramatically with major changes in their lifestyle. The course of improvement in these 3 patients was different in each, implying that different mechanisms were responsible for the improvement. One of the patients died unexpectedly. In this patient, there were no surviving adrenal cells. Three patients improved moderately. Patients reported that they were 'on' longer and had to take medication less often and were less dependent on individual doses of levodopa/carbidopa. The improvement has been sustained in two patients. However, in one of these patients there had to be frequent changes in scheduling to maintain the improvement. Two patients after technically successful implants did not improve. One of these patients subsequently died. In this patient there were a few surviving adrenal medullary cells. Four patients suffered major complications. One patient had a cerebral infarction and two had cerebral hemorrhages. One of these patients has shown a good recovery. One patient with autonomic insufficiency had a cardiac arrest with cerebral anoxia one week after surgery. This patient has shown a partial recovery.(ABSTRACT TRUNCATED AT 250 WORDS)
— id: 67629, year: 1989, vol: 126, page: 189, stat: Journal Article,

Changes in lactate levels with decreased oxygen delivery and oxygen consumption under anesthesia
Lubarsky D; Kaufman B
1989 ;68:S171-S171, Anesthesia & analgesia
— id: 47241, year: 1989, vol: 68, page: S171, stat: Journal Article,

Oxygen delivery under anesthesia: a prospective evaluation of 330ml/min/m2 as "critical" value
Lubarsky D; Kaufman B
1989 ;68:S173-S173, Anesthesia & analgesia
— id: 47242, year: 1989, vol: 68, page: S173, stat: Journal Article,

Anesthesia unmasking benign Wolff-Parkinson-White syndrome
Lubarsky D; Kaufman B; Turndorf H
1989 Feb;68(2):172-174, Anesthesia & analgesia
— id: 10725, year: 1989, vol: 68, page: 172, stat: Journal Article,

The effects of induction of anesthesia on mixed venous and peripheral venous oxygen saturations
Lubarsky D; Kaufman BS; Sharnick S; Turndorf H
1989 ;68:S172-S172, Anesthesia & analgesia
— id: 47243, year: 1989, vol: 68, page: S172, stat: Journal Article,

Esmolol use during resection of pheochromocytoma: report of three cases
Zakowski M; Kaufman B; Berguson P; Tissot M; Yarmush L; Turndorf H
1989 May;70(5):875-877, Anesthesiology
— id: 10660, year: 1989, vol: 70, page: 875, stat: Journal Article,

Relationship of oxygen delivery and mixed venous oxygenation to lactic acidosis in patients with sepsis and acute myocardial infarction
Astiz ME; Rackow EC; Kaufman B; Falk JL; Weil MH
1988 Jul;16(7):655-658, Critical care medicine
Critical decreases in oxygen delivery (DO2) and mixed venous oxygen saturation (SvO2) are associated with anaerobic metabolism and, therefore, lactic acidosis. We studied 50 consecutive patients with sepsis and 50 consecutive patients with acute myocardial infarction (AMI) in whom the arterial blood lactate was greater than 1 mmol/L in order to determine critical thresholds of DO2 and SvO2. In both groups, critical values of DO2 or SvO2 associated with lactic acidosis could not be identified. The DO2 ranged from 136 to 811 ml/min.m2 and SvO2 ranged from 28% to 73% in the patients with sepsis. The DO2 ranged from 115 to 434 ml/min.m2 and SvO2 from 17% to 72% in patients with AMI. The absence of threshold values for DO2 and SvO2 probably reflects the influence of distributive flow abnormalities as well as differences in metabolic requirements in these critically ill patients
— id: 19996, year: 1988, vol: 16, page: 655, stat: Journal Article,

Occlusion of the right pulmonary artery by an acute dissecting aortic aneurysm
Kutcher WL; Kaufman BS
1988 May;16(5):564-565, Critical care medicine
— id: 11105, year: 1988, vol: 16, page: 564, stat: Journal Article,

Oxygen delivery and consumption in patients with hyperdynamic septic shock
Astiz ME; Rackow EC; Falk JL; Kaufman BS; Weil MH
1987 Jan;15(1):26-28, Critical care medicine
We analyzed the relationship of increases in oxygen delivery to changes in oxygen consumption in ten patients with hyperdynamic septic shock. Increases in oxygen delivery from 413 +/- 14 (SEM) to 535 +/- 19 ml/min X m2 (p less than .01) were associated with increases in oxygen consumption from 136 +/- 10 to 161 +/- 5 ml/min X m2 (p less than .05). Arterial lactate decreased from 4.6 +/- 1.6 to 2.1 +/- 0.3 mmol/L (p less than .05). These observations suggest that oxygen utilization is perfusion-limited in hyperdynamic septic shock
— id: 20012, year: 1987, vol: 15, page: 26, stat: Journal Article,

Adult respiratory distress syndrome following orogenital sex during pregnancy
Kaufman BS; Kaminsky SJ; Rackow EC; Weil MH
1987 Jul;15(7):703-704, Critical care medicine
— id: 20007, year: 1987, vol: 15, page: 703, stat: Journal Article,

Hemodynamic response to fluid repletion in patients with septic shock: evidence for early depression of cardiac performance
Rackow EC; Kaufman BS; Falk JL; Astiz ME; Weil MH
1987 ;22(1):11-22, Circulatory shock
We prospectively studied 18 patients with septic shock prior to and during volume infusion in order to evaluate their hemodynamic response to fluid repletion. Fluid challenge increased left heart filling pressure from 7.7 +/- 0.5 to 15.4 +/- 0.6 mm Hg (P less than .01). The increases in left ventricular filling were associated with significant increases in stroke volume index from 25.4 +/- 2.5 to 35.7 +/- 2.5 ml/min/M2 and cardiac index from 2.49 +/- 0.19 to 3.32 +/- 0.16 L/min/M2. However, at the end of fluid challenge, the patients exhibited depressed left ventricular performance as evidenced by a left ventricular stroke work index of 29.5 +/- 2.6 g X m/M2. Over the next 24 hours of maintenance fluid infusion, the left ventricular stroke work index increased to 36.8 +/- 4.2 g X m/M2 (not significant). These data suggest that volume infusion restores ventricular filling in patients with sepsis. Although fluid repletion increases stroke and cardiac output, depressed left ventricular performance appears to be an early finding in septic shock
— id: 20013, year: 1987, vol: 22, page: 11, stat: Journal Article,

Relationship of mixed venous oxygen saturation to lactic acidosis in patients with circulatory shock
Astiz M; Rackow EC; Kaufman BS; Weil MH
1986 ;14:339-339, Critical care medicine
— id: 47319, year: 1986, vol: 14, page: 339, stat: Journal Article,

Fluid resuscitation in circulatory shock. Colloids versus crystalloids
Kaufman BS; Rackow EC; Falk JL
1986 ;20(53):186-198, Current studies in hematology & blood transfusion
— id: 20022, year: 1986, vol: 20, page: 186, stat: Journal Article,

MIXED VENOUS OXYGEN-SATURATION IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION AND HYPOPERFUSION
ASTIZ, ME; RACKOW, EC; FALK, JL; KAUFMAN, BS; WEIL, MH
1985 ;33(3):A738-A738, Clinical research
— id: 109650, year: 1985, vol: 33, page: A738, stat: Journal Article,

RELATIONSHIP OF OXYGEN DELIVERY TO LACTIC-ACIDOSIS IN PATIENTS WITH CIRCULATORY SHOCK
ASTIZ, ME; RACKOW, EC; KAUFMAN, BS; WEIL, MH
1985 ;33(4):A864-A864, Clinical research
— id: 109651, year: 1985, vol: 33, page: A864, stat: Journal Article,

REVERSIBLE MYOCARDIAL DYSFUNCTION IN PATIENTS WITH SEPTIC SHOCK
RACKOW, EC; KAUFMAN, BS; FALK, JL; ASTIZ, ME; WEIL, MH
1985 ;33(2):A295-A295, Clinical research
— id: 109657, year: 1985, vol: 33, page: A295, stat: Journal Article,

AGE-RELATED CARDIAC-FUNCTION IN PATIENTS WITH SEPTIC SHOCK
ASTIZ, ME; RACKOW, EC; FALK, JL; KAUFMAN, BS; WEIL, MH
1984 ;32(4):A727-A727, Clinical research
— id: 109658, year: 1984, vol: 32, page: A727, stat: Journal Article,

The relationship between oxygen delivery and consumption during fluid resuscitation of hypovolemic and septic shock
Kaufman BS; Rackow EC; Falk JL
1984 Mar;85(3):336-340, Chest
The effects of increasing oxygen delivery (DO2) on oxygen consumption (VO2) in eight patients with septic shock and five patients with hypovolemic shock were studied during fluid resuscitation. In the septic shock group, DO2 increased from 315 +/- 29 to 424 +/- 25 ml/min/m2 (p less than 0.01) and VO2 increased from 134 +/- 8 to 151 +/- 7 ml/min/m2 (p less than 0.01). In the hypovolemic shock group, DO2 increased from 239 +/- 26 to 386 +/- 48 ml/min/m2 (p less than 0.01) and VO2 increased from 96 +/- 9 to 135 +/- 6 ml/min/m2 (p less than 0.01). There was no significant difference in either the increase in DO2 or VO2 between the septic shock and hypovolemic shock patients. We conclude that increasing DO2 by fluid resuscitation increases VO2 during both hypovolemic and septic shock
— id: 20037, year: 1984, vol: 85, page: 336, stat: Journal Article,

ARTERIAL-PRESSURE AND MORTALITY IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION
KAUFMAN, BS; RACKOW, EC; FALK, JL; ASTIZ, ME; WEIL, MH
1984 ;32(4):A778-A778, Clinical research
— id: 109661, year: 1984, vol: 32, page: A778, stat: Journal Article,

INCREASED METABOLIC DEMANDS IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION AND LEFT-VENTRICULAR FAILURE
KAUFMAN, BS; RACKOW, EC; FALK, JL; ASTIZ, ME; WEIL, MH
1984 ;70(4):309-309, Circulation
— id: 109659, year: 1984, vol: 70, page: 309, stat: Journal Article,

SYSTEMIC OXYGEN-DEMAND IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION
KAUFMAN, BS; RACKOW, EC; FALK, JL; ASTIZ, ME; WEIL, MH
1984 ;32(2):A251-A251, Clinical research
— id: 109660, year: 1984, vol: 32, page: A251, stat: Journal Article,

Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock
Rackow EC; Falk JL; Fein IA; Siegel JS; Packman MI; Haupt MT; Kaufman BS; Putnam D
1983 Nov;11(11):839-850, Critical care medicine
Twenty-six consecutive patients in hypovolemic shock were randomized to fluid challenge with 5% albumin (A), 6% hetastarch (H), or 0.9% saline (S) solutions. Fluid challenge consisted of 250 ml of test fluid every 15 min until the pulmonary artery wedge pressure (WP) reached 15 mm Hg. Thereafter, WP was maintained at 15 mm Hg for an additional 24 h with infusions of the same test fluid. Vital signs, hemodynamic and respiratory variables, as well as arterial lactate and colloid osmotic pressure (COP) were monitored according to protocol. Chest x-rays were performed by standardized technique before fluid challenge and at 12 and 24 h of maintenance fluid therapy and were evaluated for evidence of pulmonary edema. Cardiac function and hemodynamic stability were restored by fluid challenge with A, H, and S. Two to 4 times the volume of S as A or H was required to achieve similar hemodynamic endpoints. COP was increased by fluid challenge with A or H but was markedly reduced by fluid challenge with S and throughout the 24-h maintenance period. Fluid challenge resulted in reductions in COP-WP gradient of 62% in the A, 43% in the H, and 125% in the S groups. Resuscitation with S resulted in a significantly higher incidence of pulmonary edema (87.5%) than did resuscitation with A (22%) or H (22%). Urine output was not different among the groups at any time during the study. We conclude that 6% H performs as well as 5% A as a resuscitative fluid and that resuscitation with either of these colloids is associated with a lower incidence of pulmonary edema than is resuscitation with 0.9% S
— id: 20038, year: 1983, vol: 11, page: 839, stat: Journal Article,