Norman B. Javitt

Biosketch / Results /

Norman Javitt

Research Professor, Department of Medicine
Research Professor, Department of Pediatrics


Contact Info

Address
462 First Avenue
New York, NY 10016

212/263-6588
Norman.Javitt@nyumc.org

Education

1957-1958 — Mount Sinai Medical Center (Medicine), Residency Training
1958-1959 — Columbia Presbyterian Medical Center (Medicine), Clinical Fellowships
— Duke University, School of Medicine, Medical Education
1954-1955 — Mount Sinai Medical Center (Rotating), Internship

Research Summary

Bile acid synthesis is the major metabolic pathway for the elimination of cholesterol. In addition to the pathway for bile acids that begins in the liver and is augmented with interruption of the enterohepatic circulation, a regulatory pathway has recently been discovered that begins with the production of 27-hydroxycholesterol in the aortic endothelium, macrophages, and other tissues. Our National Institutes of Health-funded research program is directed at the delineation of all the intermediates in the regulatory pathway and the determination of their biologic effects. We have already shown that 27-hydroxycholesterol is a potent inhibitor of cholesterol synthesis and LDL receptor activity. We are now investigating other biologic effects that may also occur.

A critical enzymatic step in the regulatory pathway is 7a-hydroxycholesterol which is catalyzed by a novel P-450 enzyme recently identified in our laboratory. This enzyme not only modifies the biologic effects of 27-hydroxycholesterol but also prevents the formation of monohydroxy bile acids which are known cholestatic agents. Thus, a second aspect of our research program is the metabolic basis of cholestatic liver disease.

Research Interests

Metabolic Pathways of Bile Acid Synthesis from Cholesterol

Breast cancer and (25R)-26-hydroxycholesterol
Javitt, Norman B. Breast cancer and (25R)-26-hydroxycholesterol. Steroids. 2015 Aug 20;104:61-64 (1741972)

History of hepatic bile formation: old problems, new approaches
Javitt, Norman B. History of hepatic bile formation: old problems, new approaches. Advances in physiology education. 2014 Dec ;38(4):279-285 (1369132)

Alzheimer's Disease: Neuroprogesterone, Epoxycholesterol, and ABC Transporters as Determinants of Neurodesmosterol Tissue Levels and its Role in Amyloid Protein Processing
Javitt, Norman B. Alzheimer's Disease: Neuroprogesterone, Epoxycholesterol, and ABC Transporters as Determinants of Neurodesmosterol Tissue Levels and its Role in Amyloid Protein Processing. Journal of Alzheimer's disease. 2013 ;35(3):441-450 (335492)

Alzheimer's Disease: Brain Desmosterol Levels
Wisniewski, Thomas; Newman, Kia; Javitt, Norman B. Alzheimer's Disease: Brain Desmosterol Levels. Journal of Alzheimer's disease. 2013 ;33(3):881-888 (180033)

27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols
Fakheri, Robert J; Javitt, Norman B. 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. Steroids. 2012 Feb 15;77(6):575-577 (164340)