Biosketch / Results /

Sumayah Jamal

Clinical Assistant Professor, Department of Ronald O. Perelman Department of Dermatology;Research Assistant Professor, Department of Microbiology
Microbiology

Contact Info

212/229-0333


Education

1994 — NYU, Medical Education
1994-1995 — Columbia Presbyterian, Dept. of Medicine 7/1/1994-6/30/1995, Internship
1995-1998 — NYU, Dept. of Dermatology 7/1/1995-6/30/1998, Residency Training

Research Summary

While the cure rate for localized melanoma approaches 100% using surgical modalities, the prognosis for metastatic melanoma is poor indeed. It is therefore necessary to find effective and specific therapeutic modalities for this devastating disease entity. My lab investigates molecular mechanisms that promote melanoma invasion.
Specifically we are studying the role of the endothelin pathway in melanoma development and progression. Importantly we are looking at drugs that specifically block this pathway in vivo. Our current studies focus on the regulation of adhesion molecule expression by endothelin in melanocytes and melanoma cells. We are also conducting animal studies investigating the ability of endothelin receptor antagonists to prevent melanoma metastasis. We anticipate conducting phase I clinical trials using these antagonists in the foreseeable future.

Research Interests

Malignant Melanoma

Endothelin-1 in the tumor microenvironment correlates with melanoma invasion
Chiriboga, Luis; Meehan, Shane; Osman, Iman; Glick, Michael; de la Cruz, Gelo; Howell, Brittny S; Friedman-Jimenez, George; Schneider, Robert J; Jamal, Sumayah. Endothelin-1 in the tumor microenvironment correlates with melanoma invasion. Melanoma research. 2016 Jan;:?-? (1929752)

Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes
Williams, Brittny; Schneider, Robert J; Jamal, Sumayah. Akt and PI3K-dependent but CREB-independent upregulation of MCAM by endothelin-3 in human melanocytes. Melanoma research. 2014 Apr;24(4):404-407 (962552)

Skin cancer awareness in communities of color
Imahiyerobo-Ip, Joyce; Ip, Ivan; Jamal, Sumayah; Nadiminti, Uma; Sanchez, Miguel. Skin cancer awareness in communities of color [Letter]. Journal of the American Academy of Dermatology. 2011 Jan;64(1):198-200 (133200)

Regulation of Melanoma Cell Adhesion Molecule by endothelin-1 in human melanocytes
Jamal, S; Williams, BS. Regulation of Melanoma Cell Adhesion Molecule by endothelin-1 in human melanocytes [Meeting Abstract]. Journal of investigative dermatology. 2006 APR ;126(1):151-151 (70335)

Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells
Mangahas, Catherine R; dela Cruz, Gelo V; Friedman-Jimenez, George; Jamal, Sumayah. Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells. Journal of investigative dermatology. 2005 Aug;125(2):307-311 (57870)