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Giorgio G Inghirami, M.D.
Adjunct Associate Professor;Department of Pathology (Pathology)
Contact Info
Address
550 First Avenue
Floor 5 Room 538MSB
Medical Science Building
New York,
NY
10016
212-263-5910, 212-263-7768, 212-263-8962
212-263-7712
Giorgio.Inghirami@nyumc.org
Education
1986-1987 — NYU Medical Center (Pathology), Residency1987-1990 — Columbia University (Pathology), Residency
Research Summary
Primarily, we study the molecular characterization of lymphoproliferative disorders with ongoing studies in three areas: Firstly, we focus on the clinicopathologic characteristics and pathogenetic mechanisms involved in the development and tumor progression of AIDS-associated lymphoma. We analyze the pathogenetic relationship between the clonal B-cell populations present in benign lymphoid hyperplasias and the development of non-Hodgkin's lymphoma and identification of proto-oncogene and tumor suppressor gene alterations.Secondly, we characterize the lineage, clonality, proto-oncogene, and tumor suppressor gene alterations and chromosomal abnormalities of Reed-Sternberg cells in Hodgkin disease and CD30 anaplastic large cell lymphoma, using Southern blot, PCR, in-situ PCR, and FISH analyses.
Thirdly, we identify new molecular genetic lesions leading to the transformation of low- to high-grade lymphoma using comparative genomic hybridization and/or representational difference analysis.
