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Biosketch / Results /
Xi Huang, Ph.D.
Research Associate Professor;Departments of Medicine (Medicine) and Environmental Medicine
Contact Info
Address
550 First Avenue
Department of Environmental Medicine and Medicine Floor 16 Room 1612A
NYU Hospital for Joint Diseases
New York,
NY
10016
212-598-7642, 212-598-6189
212-598-7604
Xi.Huang@nyumc.org
Education
1991 — Dr. Huang received his Ph.D. from the University of Paris VII, Paris, France, Graduate EducationResearch Summary
Dr. Huang''s current research is on the toxicological aspects of iron, either from endogenous sources or from environmental pollutants. While iron deficiency causes anemia, iron overload may increase the risk of various diseases, such as cancer and fibrosis. Specific projects include: mechanisms of iron-containing coal in inducing chronic obstructive pulmonary disease such as pneumoconiosis, pathogenesis of iron overload in hemochromatosis, and the interaction of iron with estrogens in breast cancer. Molecular biology and epidemiology approaches are the main tools applied in the laboratory for addressing the health issue of iron, an essential element.
Research Interests
Oxidative stress, inflammatory cytokines, Iron and estrogen interaction, breast cancer, chronic obstructive pulmonary disease<br>Grant Keywords
DNA, Hormone Replacement Therapy, Occupational Health and Safety, Breast Cancer, Pulmonary Diseases, Cancer/Carcinogenesis, Inflammation, Cancer BiologyAll data from NYU Health Sciences Library Faculty Bibliography — -
Oral contraceptive use, iron stores and vascular endothelial function in healthy women
Friedman, Julie; Cremer, Miriam; Jelani, Qurat Ul-Ain; Huang, Xi; Jian, Jinlong; Shah, Sooraj; Katz, Stuart D
2011 Sep;84(3):285-290, Contraception
—
id: 136646,
year: 2011,
vol: 84,
page: 285,
stat: Journal Article,
Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study
Huang, Xi; Katz, Stuart
2011 Aug;94(2):613-614, American journal of clinical nutrition
—
id: 135553,
year: 2011,
vol: 94,
page: 613,
stat: Journal Article,
Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-alpha and ERK activation
Jian, Jinlong; Pelle, Edward; Yang, Qing; Pernodet, Nadine; Maes, Daniel; Huang, Xi
2011 Mar;20(3):249-254, Experimental dermatology
—
id: 123202,
year: 2011,
vol: 20,
page: 249,
stat: Journal Article,
Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer (vol 50, pg 841, 2011)
Jian, Jinlong; Yang, Qing; Dai, Jisen; Eckard, Jonathan; Axelrod, Deborah; Smith, Julia; Huang, Xi
2011 JUL 1 ;51(1):243-243, Free radical biology & medicine
—
id: 134497,
year: 2011,
vol: 51,
page: 243,
stat: Journal Article,
Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer
Jian, Jinlong; Yang, Qing; Dai, Jisen; Eckard, Jonathan; Axelrod, Debrah; Smith, Julia; Huang, Xi
2011 Apr 1;50(7):841-847, Free radical biology & medicine
—
id: 130294,
year: 2011,
vol: 50,
page: 841,
stat: Journal Article,
SRC regulates tyr20 phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival
Jian, Jinlong; Yang, Qing; Huang, Xi
2011 Oct 14;286(41):35708-35715, Journal of biological chemistry
—
id: 138710,
year: 2011,
vol: 286,
page: 35708,
stat: Journal Article,
Protection against ultraviolet A-induced oxidative damage in normal human epidermal keratinocytes under post-menopausal conditions by an ultraviolet A-activated caged-iron chelator: a pilot study
Pelle, Edward; Jian, Jinlong; Declercq, Lieve; Dong, Kelly; Yang, Qing; Pourzand, Charareh; Maes, Daniel; Pernodet, Nadine; Yarosh, Daniel B; Huang, Xi
2011 Oct;27(5):231-235, Photodermatology, photoimmunology, & photomedicine
—
id: 137893,
year: 2011,
vol: 27,
page: 231,
stat: Journal Article,
Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis
Yang, Qing; Jian, Jinlong; Abramson, Steven B; Huang, Xi
2011 Jun;26(6):1188-1196, Journal of bone & mineral research
—
id: 132876,
year: 2011,
vol: 26,
page: 1188,
stat: Journal Article,
Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis
Eckard, Jonathan; Dai, Jisen; Wu, Jing; Jian, Jinlong; Yang, Qing; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2010 ;10:28-28, Cancer cell international
—
id: 114147,
year: 2010,
vol: 10,
page: 28,
stat: Journal Article,
Effects of Iron Deficiency Anemia on the Formation of Vascular Endothelial Growth Factor, Angiogenesis, and Metastasis
Huang, Xi; Jian, Jinlong; Yang, Qing
2010 JAN ;49(1):S62-S62, Free radical biology & medicine
—
id: 119121,
year: 2010,
vol: 49,
page: S62,
stat: Journal Article,
Targeting CDK4/CDK6 impairs osteoclast progenitor pool expansion and blocks osteolytic lesion development in multiple myeloma
Feng R.; Huang X.; Coulton L.; De Raeve H.; DiLiberto M.; Ely S.; Xiao G.; Luo M.; Menu E.; Croucher P.; Roodman G.D.; Vanderkerken K.; Chen-Kiang S.; Lentzsch S.
2009 ;114(22):?-? #298, Blood
—
id: 112212,
year: 2009,
vol: 114,
page: ?,
stat: Journal Article,
Human skin fibroblasts under post-menopausal conditions are more sensitive to UVA-induced MMP-1 expression
Jian, J; Yang, Q; Huang, X; Pelle, E; Pernodet, N; Maes, D
2009 APR ;129(5):S131-S131, Journal of investigative dermatology
—
id: 97877,
year: 2009,
vol: 129,
page: S131,
stat: Journal Article,
Iron and menopause: does increased iron affect the health of postmenopausal women?
Jian, Jinlong; Pelle, Edward; Huang, Xi
2009 Dec;11(12):2939-2943, Antioxidants & Redox Signaling
—
id: 105496,
year: 2009,
vol: 11,
page: 2939,
stat: Journal Article,
Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status
Dai, Jisen; Jian, Jinlong; Bosland, Maarten; Frenkel, Krystyna; Bernhardt, Guenther; Huang, Xi
2008 Apr;17(2):172-179, Breast
—
id: 80282,
year: 2008,
vol: 17,
page: 172,
stat: Journal Article,
Does iron have a role in breast cancer?
Huang, Xi
2008 Aug;9(8):803-807, Lancet oncology
—
id: 93344,
year: 2008,
vol: 9,
page: 803,
stat: Journal Article,
Understanding the chemical properties of macerals and minerals in coal and its potential application for occupational lung disease prevention
Huang, Xi; Finkelman, Robert B
2008 Jan;11(1):45-67, Journal of toxicology & environmental health. Pt. B. Critical reviews
—
id: 75681,
year: 2008,
vol: 11,
page: 45,
stat: Journal Article,
Serum prohepcidin is associated with soluble transferrin receptor-1 but not ferritin in healthy post-menopausal women
Huang, Xi; Fung, Eric T; Yip, Christine; Zeleniuch-Jacquotte, Anne
2008 Nov-Dec;41(3):265-269, Blood cells, molecules, & diseases
—
id: 93350,
year: 2008,
vol: 41,
page: 265,
stat: Journal Article,
Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes
Pelle, Edward; McCarthy, James; Seltmann, Holger; Huang, Xi; Mammone, Thomas; Zouboulis, Christos C; Maes, Daniel
2008 May;128(5):1280-1285, Journal of investigative dermatology
—
id: 132261,
year: 2008,
vol: 128,
page: 1280,
stat: Journal Article,
Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase
Huang, Xi; Dai, Jisen; Huang, Chuanshu; Zhang, Qi; Bhanot, Opinder; Pelle, Edward
2007 Oct;41(10):1135-1142, Free radical research
—
id: 75378,
year: 2007,
vol: 41,
page: 1135,
stat: Journal Article,
The effects of iron in a keratinocyte-derived post-menopausal cellular model
Pelle, E; Dai, J; McCarthy, J; Mammone, T; Maes, D; Huang, X
2007 APR ;127(2):S82-S82, Journal of investigative dermatology
—
id: 71620,
year: 2007,
vol: 127,
page: S82,
stat: Journal Article,
Reliability of serum assays of iron status in postmenopausal women
Zeleniuch-Jacquotte, Anne; Zhang, Qi; Dai, Jisen; Shore, Roy E; Arslan, Alan A; Koenig, Karen L; Karkoszka, Jerzy; Afanasyeva, Yelena; Frenkel, Krystyna; Toniolo, Paolo; Huang, Xi
2007 May;17(5):354-358, Annals of epidemiology
—
id: 73252,
year: 2007,
vol: 17,
page: 354,
stat: Journal Article,
Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure
Hu, Y; Zhou, Z; Xue, X; Li, X; Fu, J; Cohen, B; Melikian, A A; Desai, M; Tang, M -S; Huang, X; Roy, N; Sun, J; Nan, P; Qu, Q
2006 Jul-Aug;11(4):306-318, Biomarkers
—
id: 68305,
year: 2006,
vol: 11,
page: 306,
stat: Journal Article,
Interaction of iron and calcium minerals in coals and their roles in coal dust-induced health and environmental problems
Huang, X; Gordon, T; Rom, WN; Finkelman, RB
2006 NOV-DEC ;64(6):153-178, Reviews in mineralogy & geochemistry
—
id: 70749,
year: 2006,
vol: 64,
page: 153,
stat: Journal Article,
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes
Li, Qin; Chen, Haobin; Huang, Xi; Costa, Max
2006 Jun 15;213(3):245-255, Toxicology & applied pharmacology
—
id: 65794,
year: 2006,
vol: 213,
page: 245,
stat: Journal Article,
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis
Tanaka, T; Kurose, A; Huang, X; Dai, W; Darzynkiewicz, Z
2006 Feb;39(1):49-60, Cell proliferation
—
id: 76366,
year: 2006,
vol: 39,
page: 49,
stat: Journal Article,
Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status
Tanaka, T; Kurose, A; Huang, X; Traganos, F; Dai, W; Darzynkiewicz, Z
2006 Aug;39(4):313-323, Cell proliferation
—
id: 76365,
year: 2006,
vol: 39,
page: 313,
stat: Journal Article,
Altered iron homeostasis involvement in arsenite-mediated cell transformation
Wu, Jing; Eckard, Jonathan; Chen, Haobin; Costa, Max; Frenkel, Krystyna; Huang, Xi
2006 Feb 1;40(3):444-452, Free radical biology & medicine
—
id: 64134,
year: 2006,
vol: 40,
page: 444,
stat: Journal Article,
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects
Zheng, H; Huang, X; Zhang, Q; Katz, S D
2006 Feb;69(4):679-684, Kidney international
—
id: 132262,
year: 2006,
vol: 69,
page: 679,
stat: Journal Article,
Mapping and prediction of coal workers' pneumoconiosis with bioavailable iron content in the bituminous coals
Huang, Xi; Li, Weihong; Attfield, Michael D; Nadas, Arthur; Frenkel, Krystyna; Finkelman, Robert B
2005 Aug;113(8):964-968, Environmental health perspectives
—
id: 62597,
year: 2005,
vol: 113,
page: 964,
stat: Journal Article,
Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells
Yang, Chengfeng; Wu, Jing; Zhang, Ronghe; Zhang, Ping; Eckard, Jonathan; Yusuf, Rita; Huang, Xi; Rossman, Toby G; Frenkel, Krystyna
2005 Sep 15;213(1-2):81-96, Toxicology
—
id: 58743,
year: 2005,
vol: 213,
page: 81,
stat: Journal Article,
Addition of calcite reduces iron's bioavailability in the Pennsylvania coals--potential use of calcite for the prevention of coal workers' lung diseases
Zhang, Qi; Huang, Xi
2005 Oct 8;68(19):1663-1679, Journal of toxicology & environmental health. Pt. A
—
id: 58699,
year: 2005,
vol: 68,
page: 1663,
stat: Journal Article,
Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids
Ali, Aktar; Zhang, Qi; Dai, Jisen; Huang, Xi
2003 Jun;16(2):285-293, Biometals
—
id: 39312,
year: 2003,
vol: 16,
page: 285,
stat: Journal Article,
Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women
Ali, M Aktar; Akhmedkhanov, Arslan; Zeleniuch-Jaquotte, Anne; Toniolo, Paolo; Frenkel, Krystyna; Huang, Xi
2003 ;27(2):116-121, Cancer detection & prevention
—
id: 34537,
year: 2003,
vol: 27,
page: 116,
stat: Journal Article,
Gene expression of primary human bronchial epithelial cells in response to coal dusts with different prevalence of coal workers' pneumoconiosis
Hu, Wenwei; Zhang, Qi; Su, Wei Cheng; Feng, Zhaohui; Rom, William; Chen, Lung Chi; Tang, Moonshong; Huang, Xi
2003 Jul 11;66(13):1249-1265, Journal of toxicology & environmental health. Pt. A
—
id: 39145,
year: 2003,
vol: 66,
page: 1249,
stat: Journal Article,
Coal-induced interleukin-6 gene expression is mediated through ERKs and p38 MAPK pathways
Huang, X; Zhang, Q
2003 Aug 15;191(1):40-47, Toxicology & applied pharmacology
—
id: 39109,
year: 2003,
vol: 191,
page: 40,
stat: Journal Article,
Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger
Pelle, Edward; Huang, Xi; Mammone, Thomas; Marenus, Kenneth; Maes, Daniel; Frenkel, Krystyna
2003 Jul;121(1):177-183, Journal of investigative dermatology
—
id: 38128,
year: 2003,
vol: 121,
page: 177,
stat: Journal Article,
Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species
Zhang, Q; Huang, X
2003 Feb;28(1):95-100, Journal of biosciences
—
id: 39248,
year: 2003,
vol: 28,
page: 95,
stat: Journal Article,
Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts
Huang, Chuanshu; Li, Jingxia; Zhang, Qi; Huang, Xi
2002 Nov;27(5):568-574, American journal of respiratory cell & molecular biology
—
id: 38471,
year: 2002,
vol: 27,
page: 568,
stat: Journal Article,
Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells
Huang, Xi; Dai, Jisen; Fournier, Jeanine; Ali, Aktar M; Zhang, Qi; Frenkel, Krystyna
2002 Jan 1;32(1):84-92, Free radical biology & medicine
—
id: 34035,
year: 2002,
vol: 32,
page: 84,
stat: Journal Article,
Roles of bioavailable iron and calcium in coal dust-induced oxidative stress: possible implications in coal workers' lung disease
Zhang, Qi; Dai, Jisen; Ali, Aktar; Chen, Lungchi; Huang, Xi
2002 Mar;36(3):285-294, Free radical research
—
id: 39623,
year: 2002,
vol: 36,
page: 285,
stat: Journal Article,
Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals
Zhang, Qi; Huang, Xi
2002 Sep;42(3):171-179, American journal of industrial medicine
—
id: 39595,
year: 2002,
vol: 42,
page: 171,
stat: Journal Article,
Response of avian embryonic brain to spatially segmented x-ray microbeams
Dilmanian, F A; Morris, G M; Le Duc, G; Huang, X; Ren, B; Bacarian, T; Allen, J C; Kalef-Ezra, J; Orion, I; Rosen, E M; Sandhu, T; Sathe, P; Wu, X Y; Zhong, Z; Shivaprasad, H L
2001 May;47(3):485-493, Cellular & molecular biology
—
id: 256662,
year: 2001,
vol: 47,
page: 485,
stat: Journal Article,
Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses
Huang X; Powell J; Mooney LA; Li C; Frenkel K
2001 Dec 1;31(11):1341-1351, Free radical biology & medicine
—
id: 34036,
year: 2001,
vol: 31,
page: 1341,
stat: Journal Article,
Bioavailable or potentially bioavailable iron as a biomarker of cancer risk
Huang, X; Zhang, Q; Ali, A; Dai, J S; Frenkel, K
2000 Nov 16-20;29(Supplement 1):S16-S16, Free radical biology & medicine
—
id: 15768,
year: 2000,
vol: 29,
page: S16,
stat: Journal Article,
A brief history of antibiotic science
Dai, J; Zhang, G; Huang, X; Wu, T
1999 Apr;29(2):88-90, Zhonghua yi shi za zhi = Chinese journal of medical history
—
id: 138815,
year: 1999,
vol: 29,
page: 88,
stat: Journal Article,
Chemical reactivity of the carbon-centered free radicals and ferrous iron in coals: role of bioavailable Fe2+ in coal workers pneumoconiosis
Huang X; Zalma R; Pezerat H
1999 Jun;30(6):439-451, Free radical research
—
id: 6158,
year: 1999,
vol: 30,
page: 439,
stat: Journal Article,
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
Munger JS; Huang X; Kawakatsu H; Griffiths MJ; Dalton SL; Wu J; Pittet JF; Kaminski N; Garat C; Matthay MA; Rifkin DB; Sheppard D
1999 Feb 5;96(3):319-328, Cell
—
id: 7411,
year: 1999,
vol: 96,
page: 319,
stat: Journal Article,
Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens
Rinaldo, C R Jr; Liebmann, J M; Huang, X L; Fan, Z; Al-Shboul, Q; McMahon, D K; Day, R D; Riddler, S A; Mellors, J W
1999 Feb;179(2):329-336, Journal of infectious diseases
—
id: 148352,
year: 1999,
vol: 179,
page: 329,
stat: Journal Article,
The role of ferrous sulfate in coal dust induced lung injury
Chen LC; Huang X; Wu CY; Zalma R; Perzerat H; Qu QS
1996 ;11:973-979, Applied occupational & environmental hygiene
—
id: 72668,
year: 1996,
vol: 11,
page: 973,
stat: Journal Article,


