Chuanshu Huang

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Chuanshu Huang

Professor, Department of Environmental Medicine
Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Urology

Environmental Medicine Deputy Director

Contact Info

Address
57 Old Forge Rd.
Tuxedo, NY 10987

845-731-3519
Chuanshu.Huang@nyumc.org

Research Summary

Exposure of cells to environmental carcinogens results in activation of transcription factors and regulation of their target genes through signal transduction pathways, which have been characterized as tumor promotion and progression stages of carcinogenesis.  Elucidation of signal transduction pathways will, therefore, not only define the central scientific hunt in cancer biology and open an unprecedented window into the nature of cancer, but also will be necessary for cancer prevention and therapy as well.  As a result, my research addresses fundamental questions concerning the responses of mammalian cells to environmental carcinogens at the levels of protein kinases, transcription factors and their target genes, as well as protein modification both in vitro and in vivo. My major research findings include: 1), identifying novel signaling pathways triggering cellular apoptosis in cell responses to environmental stress, such as, we identify a novel signaling pathway of p85/NFAT3/TNF for mediating cell apoptosis upon UV radiation. Our most recently studies also characterize a novel pro-apoptotic pathway of IKK/NF-κB p50/GADD45/JNK in cellular response to arsenite; 2), demonstrating role of the transcription factor NFAT in environmental carcinogenic response; 3), elucidating molecular mechanisms of carcinogenic effect of arsenite exposure; 4), initiating finding of crucial role of PI-3K/Akt pathway in carcinogenic responses and as a target for chemoprevention; 5), identifying a novel function of XIAP acting as a modulator of RhoGDI sumoylation, by which XIAP mediates cancer cell motility and metastasis.

Research Keywords

signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention, reactive oxygen species (ROS) involved in cellular signaling and cancer development, molecular mechanism of anti-cancer nutrients, environment and carcinogenesis, cancer

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell
Huang, Chao; Zeng, Xingruo; Jiang, Guosong; Liao, Xin; Liu, Claire; Li, Jingxia; Jin, Honglei; Zhu, Junlan; Sun, Hong; Wu, Xue-Ru; Huang, Chuanshu. XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. Journal of hematology & oncology. 2017 Jan 05;10(1):6-6 (2386822)

Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation
Zhang, Ruowen; Che, Xun; Zhang, Jingjie; Li, Yang; Li, Jingxia; Deng, Xu; Zhu, Junlan; Jin, Honglei; Zhao, Qinshi; Huang, Chuanshu. Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation. Oncotarget. 2016 Oct 11;7(41):66689-66699 (2221532)

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells
Huang, Haishan; Zhu, Junlan; Li, Yang; Zhang, Liping; Gu, Jiayan; Xie, Qipeng; Jin, Honglei; Che, Xun; Li, Jingxia; Huang, Chao; Chen, Lung-Chi; Lyu, Jianxin; Gao, Jimin; Huang, Chuanshu. Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Autophagy. 2016 Oct 02;12(10):1687-1703 (2191672)

XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63alpha protein translation and promoting transformation of bladder epithelial cells
Jin, Honglei; Xu, Jiheng; Guo, Xirui; Huang, Haishan; Li, Jingxia; Peng, Minggang; Zhu, Junlan; Tian, Zhongxian; Wu, Xue-Ru; Tang, Moon-Shong; Huang, Chuanshu. XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63alpha protein translation and promoting transformation of bladder epithelial cells. Oncotarget. 2016 Aug 30;7(35):56540-56557 (2257972)

Tumor-suppressor NFkappaB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494
Wang, Y; Xu, J; Gao, G; Li, J; Huang, H; Jin, H; Zhu, J; Che, X; Huang, C. Tumor-suppressor NFkappaB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. Oncogene. 2016 Aug 04;35(31):4080-4090 (1884082)