Chuanshu Huang, M.D., Ph.D.

GADD45alpha Induction by Nickel Negatively Regulates JNKs/p38 Activation via Promoting PP2Calpha Expression
Yu, Yonghui; Li, Jingxia; Wan, Yu; Lu, Jianyi; Gao, Jimin; Huang, Chuanshu
2013 ;8(3):e57185-e57185 e57185, PLoS ONE
— id: 255462, year: 2013, vol: 8, page: e57185, stat: Journal Article,

MicroRNA, cancer and cancer chemoprevention
Che, X; Huang, C
2012 2012;5(3):362-371, Current molecular pharmacology
— id: 264482, year: 2012, vol: 5, page: 362, stat: Journal Article,

The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP
Fang, Yong; Yu, Yonghui; Hou, Qi; Zheng, Xiao; Zhang, Min; Zhang, Dongyun; Li, Jingxia; Wu, Xue-Ru; Huang, Chuanshu
2012 Oct;287(42):35234-35243, Journal of biological chemistry
— id: 180079, year: 2012, vol: 287, page: 35234, stat: Journal Article,

Superoxide plays critical roles in electrotaxis of fibrosarcoma cells via activation of ERK and reorganization of the cytoskeleton
Li, Fei; Wang, Hui; Li, Li; Huang, Chuanshu; Lin, Jiangkai; Zhu, Gang; Chen, Zhi; Wu, Nan; Feng, Hua
2012 May;52(9):1888-1896, Free radical biology & medicine
— id: 166979, year: 2012, vol: 52, page: 1888, stat: Journal Article,

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity
Liu, Jinyi; Zhang, Dongyun; Luo, Wenjing; Yu, Jianxiu; Li, Jingxia; Yu, Yonghui; Zhang, Xinhai; Chen, Jingyuan; Wu, Xue-Ru; Huang, Chuanshu
2012 ;7(4):e35682-e35682 e35682, PLoS ONE
— id: 165633, year: 2012, vol: 7, page: e35682, stat: Journal Article,

RhoGDI SUMOylation at K138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility
Yu, J; Zhang, D; Liu, J; Li, J; Yu, Y; Wu, XR; Huang, C
2012 Mar;:13752-13760, Journal of biological chemistry
— id: 162339, year: 2012, vol: , page: 13752, stat: Journal Article,

The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1alpha mRNA Stability
Zhang, Dongyun; Li, Jingxia; Zhang, Min; Gao, Guangxun; Zuo, Zhenghong; Yu, Yonghui; Zhu, Linda; Gao, Jimin; Huang, Chuanshu
2012 Oct;287(41):34361-34371, Journal of biological chemistry
— id: 179269, year: 2012, vol: 287, page: 34361, stat: Journal Article,

Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability
Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu
2012 Sep;263(2):218-224, Toxicology & applied pharmacology
— id: 175777, year: 2012, vol: 263, page: 218, stat: Journal Article,

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies
Zhou, H; Huang, HY; Shapiro, E; Lepor, H; Huang, WC; Mohammadi, M; Mohr, I; Tang, MS; Huang, C; Wu, XR
2012 Feb;:770-780, Carcinogenesis
— id: 162340, year: 2012, vol: , page: 770, stat: Journal Article,

Cyclooxygenase-2 (COX-2) Mediates Arsenite Inhibition of UVB-Induced Cellular Apoptosis in Mouse Epidermal Cl41 Cells
Zuo, Z; Ouyang, W; Li, J; Costa, M; Huang, C
2012 Jul;12(6):607-616, Current cancer drug targets
— id: 170417, year: 2012, vol: 12, page: 607, stat: Journal Article,

Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFkappaB/c-Jun/AP-1-Dependent Pathway
Zuo, Zhenghong; Cai, Tongjian; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Huang, Chuanshu
2012 Apr;120(4):547-553, Environmental health perspectives
— id: 163589, year: 2012, vol: 120, page: 547, stat: Journal Article,

Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells
Cai, Tongjian; Che, Honglei; Yao, Ting; Chen, Yaoming; Huang, Chuanshu; Zhang, Wenbin; Du, Kejun; Zhang, Jianbin; Cao, Yunxin; Chen, Jingyuan; Luo, Wenjing
2011 Jan;119(1):169-177, Toxicological sciences
— id: 121616, year: 2011, vol: 119, page: 169, stat: Journal Article,

A Cross-Talk Between NFAT and NF-kappaB Pathways is Crucial for Nickel-Induced COX-2 Expression in Beas-2B Cells
Cai, Tongjian; Li, Xueyong; Ding, Jin; Luo, Wenjing; Li, Jingxia; Huang, Chuanshu
2011 Jun 1;11(5):548-559, Current cancer drug targets
— id: 132877, year: 2011, vol: 11, page: 548, stat: Journal Article,

Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression
Guo, Wei; Yang, Zhuo; Xia, Qing; Liu, Jinyi; Yu, Yonghui; Li, Jingxia; Zuo, Zhenghong; Zhang, Dongyun; Li, Xueyong; Shi, Xianglin; Huang, Chuanshu
2011 Feb;68(3):475-488, Cellular & molecular life sciences: CMLS
— id: 120640, year: 2011, vol: 68, page: 475, stat: Journal Article,

Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells
Li, Fei; Wang, Hui; Huang, Chuanshu; Lin, Jiangkai; Zhu, Gang; Hu, Rong; Feng, Hua
2011 Oct;45(10):1154-1161, Free radical research
— id: 141192, year: 2011, vol: 45, page: 1154, stat: Journal Article,

The X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility Via RhoGDP dissociation inhibitor (RhoGDI)-dependent regulation of cytoskeleton
Liu J; Zhang D; Luo W; Yu Y; Yu J; Li J; Zhang X; Zhang B; Chen J; Wu XR; Rosas-Acosta G; Huang C
2011 May 6;286(18):15630-15640, Journal of biological chemistry
— id: 131663, year: 2011, vol: 286, page: 15630, stat: Journal Article,

p85alpha mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response
Song, L; Gao, M; Dong, W; Hu, M; Li, J; Shi, X; Hao, Y; Li, Y; Huang, C
2011 Mar 17;30(11):1360-1371, Oncogene
— id: 127224, year: 2011, vol: 30, page: 1360, stat: Journal Article,

p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways
Liu, Jinyi; Zhang, Dongyun; Mi, Xiaoyi; Xia, Qing; Yu, Yonghui; Zuo, Zhenghong; Guo, Wei; Zhao, Xuewei; Cao, Jia; Yang, Qing; Zhu, Angela; Yang, Wancai; Shi, Xianglin; Li, Jingxia; Huang, Chuanshu
2010 Aug 20;285(34):26058-26065, Journal of biological chemistry
— id: 138091, year: 2010, vol: 285, page: 26058, stat: Journal Article,

Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure
Luo, Wenjing; Li, Jingxia; Zhang, Dongyun; Cai, T; Song, Lun; Yin, Xiao-Ming; Desai, Dhimant; Amin, Shantu; Chen, Jingyuan; Huang, Chuanshu
2010 Feb;10(1):96-106, Current cancer drug targets
— id: 156171, year: 2010, vol: 10, page: 96, stat: Journal Article,

A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression
Song, Lun; Dong, Wen; Gao, Ming; Li, Jingxia; Hu, Meiru; Guo, Ning; Huang, Chuanshu
2010 Feb;1803(2):323-332, Biochimica & biophysica acta
— id: 106215, year: 2010, vol: 1803, page: 323, stat: Journal Article,

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70
Zhang, Dongyun; Li, Jingxia; Costa, Max; Gao, Jimin; Huang, Chuanshu
2010 Jan 15;70(2):813-823, Cancer research
— id: 106216, year: 2010, vol: 70, page: 813, stat: Journal Article,

Effects of nickel on cyclin expression, cell cycle progression and cell proliferation in human pulmonary cells
Ding, Jin; He, Guoping; Gong, Wenfeng; Wen, Wen; Sun, Wen; Ning, Beifang; Huang, Shanna; Wu, Kun; Huang, Chuanshu; Wu, Mengchao; Xie, Weifen; Wang, Hongyang
2009 Jun;18(6):1720-1729, Cancer epidemiology biomarkers & prevention
— id: 110423, year: 2009, vol: 18, page: 1720, stat: Journal Article,

TNF-alpha induction by nickel compounds is specific through ERKs/AP-1-dependent pathway in human bronchial epithelial cells
Ding, Jin; Huang, Yi; Ning, Beifang; Gong, Wenfeng; Li, Jingxia; Wang, Hongyang; Chen, Chang-Yan; Huang, Chuanshu
2009 Feb;9(1):81-90, Current cancer drug targets
— id: 97839, year: 2009, vol: 9, page: 81, stat: Journal Article,

PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells
Ding, Jin; Ning, Beifang; Huang, Yi; Zhang, Dongyun; Li, Jingxia; Chen, Chang-Yan; Huang, Chuanshu
2009 Jun;9(4):500-509, Current cancer drug targets
— id: 100190, year: 2009, vol: 9, page: 500, stat: Journal Article,

Diverse roles of GADD45alpha in stress signaling
Gao, Ming; Guo, Ning; Huang, Chuanshu; Song, Lun
2009 Aug;10(4):388-394, Current protein & peptide science
— id: 106268, year: 2009, vol: 10, page: 388, stat: Journal Article,

Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism
Liu, Mingchao; Cai, Tongjian; Zhao, Fang; Zheng, Gang; Wang, Qiang; Chen, Yaoming; Huang, Chuanshu; Luo, Wenjing; Chen, Jingyuan
2009 Jul;16(1):42-49, Neurotoxicity research
— id: 110421, year: 2009, vol: 16, page: 42, stat: Journal Article,

Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation
Ouyang, Weiming; Zhang, Dongyun; Li, Jingxia; Verma, Udit N; Costa, Max; Huang, Chuanshu
2009 Jan;218(1):205-214, Journal of cellular physiology
— id: 93369, year: 2009, vol: 218, page: 205, stat: Journal Article,

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis
Wang, P; Qiu, W; Dudgeon, C; Liu, H; Huang, C; Zambetti, G P; Yu, J; Zhang, L
2009 Sep;16(9):1192-1202, Cell death & differentiation
— id: 106254, year: 2009, vol: 16, page: 1192, stat: Journal Article,

Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades
Yang, Z; Song, L; Huang, C
2009 Dec;9(8):915-930, Current cancer drug targets
— id: 105986, year: 2009, vol: 9, page: 915, stat: Journal Article,

The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target
Yu, Yonghui; Wan, Yu; Huang, Chuanshu
2009 Jun;9(4):566-571, Current cancer drug targets
— id: 110422, year: 2009, vol: 9, page: 566, stat: Journal Article,

A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression. (vol 6, pg 165, 2008) [Correction]
Zhang, D; Huang, CS
2009 SEP ;7(9):1593-1593, Molecular cancer research
— id: 102960, year: 2009, vol: 7, page: 1593, stat: Journal Article,

c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells
Zhang, Dongyun; Li, Jingxia; Gao, Jimin; Huang, Chuanshu
2009 Feb 15;235(1):18-24, Toxicology & applied pharmacology
— id: 97450, year: 2009, vol: 235, page: 18, stat: Journal Article,

gamma-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory
Zheng, Gang; Zhang, Wenbin; Zhang, Yun; Chen, Yaoming; Liu, Mingchao; Yao, Ting; Yang, Yanxia; Zhao, Fang; Li, Jingxia; Huang, Chuanshu; Luo, Wenjing; Chen, Jingyuan
2009 Apr 15;236(2):239-245, Toxicology & applied pharmacology
— id: 110424, year: 2009, vol: 236, page: 239, stat: Journal Article,

Benzo(a)pyrene-caused increased G(1)-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts
Jiao, Shi; Liu, Bingci; Gao, Ai; Ye, Meng; Jia, Xiaowei; Zhang, Fengmei; Liu, Haifeng; Shi, Xianglin; Huang, Chuanshu
2008 May 30;178(3):167-175, Toxicology letters
— id: 78680, year: 2008, vol: 178, page: 167, stat: Journal Article,

Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes
Li, Jingxia; Zhang, Dongyun; Stoner, Gary D; Huang, Chuanshu
2008 Apr;47(4):286-294, Molecular carcinogenesis
— id: 76764, year: 2008, vol: 47, page: 286, stat: Journal Article,

Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway
Luo, Wenjing; Liu, Jinyi; Li, Jingxia; Zhang, Dongyun; Liu, Mingchao; Addo, James K; Patil, Shivaputra; Zhang, Lin; Yu, Jian; Buolamwini, John K; Chen, Jingyuan; Huang, Chuanshu
2008 Mar 28;283(13):8624-8633, Journal of biological chemistry
— id: 79091, year: 2008, vol: 283, page: 8624, stat: Journal Article,

PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation
Ouyang, Weiming; Luo, Wenjing; Zhang, Dongyun; Jian, Jinlong; Ma, Qian; Li, Jingxia; Shi, Xianglin; Chen, Jingyuan; Gao, Jimin; Huang, Chuanshu
2008 Jan;116(1):1-6, Environmental health perspectives
— id: 76459, year: 2008, vol: 116, page: 1, stat: Journal Article,

Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway
Shen, Fuhai; Fan, Xueyun; Liu, Bingci; Jia, Xiaowei; Gao, Ai; Du, Hongju; Ye, Meng; You, Baorong; Huang, Chuanshu; Shi, Xianglin
2008 Oct;32(10):1284-1292, Cell biology international
— id: 110425, year: 2008, vol: 32, page: 1284, stat: Journal Article,

Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner
Song, Lun; Li, Jingxia; Hu, Meiru; Huang, Chuanshu
2008 Jul 1;314(11-12):2187-2198, Experimental cell research
— id: 80292, year: 2008, vol: 314, page: 2187, stat: Journal Article,

A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression
Zhang, Dongyun; Li, Jingxia; Song, Lun; Ouyang, Weiming; Gao, Jimin; Huang, Chuanshu
2008 Jan;6(1):165-174, Molecular cancer research
— id: 76464, year: 2008, vol: 6, page: 165, stat: Journal Article,

Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells
Ding, Jin; Wu, Kangjian; Zhang, Dongyun; Luo, Wenjing; Li, Jingxia; Ouyang, Weiming; Song, Lun; Huang, Chuanshu
2007 Sep;98(9):1323-1329, Cancer Science
— id: 74406, year: 2007, vol: 98, page: 1323, stat: Journal Article,

[Benzo (a) pyrene-induced human embryo lung cell cycle alterations through positive regulation of mitogen-activated protein kinase signal pathways]
DU, Hong-ju; Tang, Ning; Liu, Bing-ci; Shi, Xiang-lin; Huang, Chuan-shu; Gao, Ai; Shen, Fu-hai; Ye, Meng; You, Bao-rong
2007 Jul;41(4):277-280, Zhonghua Yu Fang Yi Xue Za Zhi = Chinese journal of preventive medicine
— id: 132264, year: 2007, vol: 41, page: 277, stat: Journal Article,

Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts
Gao, Ai; Liu, Bingci; Shi, Xianglin; Jia, Xiaowei; Ye, Meng; Jiao, Shi; You, Baorong; Huang, Chuanshu
2007 Apr 5;170(1):30-41, Toxicology letters
— id: 106250, year: 2007, vol: 170, page: 30, stat: Journal Article,

Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries
Huang, Chuanshu; Zhang, Dongyun; Li, Jingxia; Tong, Qiangsong; Stoner, Gary D
2007 ;58(2):205-212, Nutrition & cancer
— id: 73921, year: 2007, vol: 58, page: 205, stat: Journal Article,

Transription factors and their modulated genes as targets for chemoprevention
Huang, CS
2007 JUN ;7(4):303-303, Current cancer drug targets
— id: 73148, year: 2007, vol: 7, page: 303, stat: Journal Article,

Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase
Huang, Xi; Dai, Jisen; Huang, Chuanshu; Zhang, Qi; Bhanot, Opinder; Pelle, Edward
2007 Oct;41(10):1135-1142, Free radical research
— id: 75378, year: 2007, vol: 41, page: 1135, stat: Journal Article,

Transcription factor NFAT, its role in cancer development, and as a potential target for chemoprevention
Lu, Haitian; Huan, Chuanshu
2007 Jun;7(4):343-353, Current cancer drug targets
— id: 75482, year: 2007, vol: 7, page: 343, stat: Journal Article,

Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells
Ouyang, Weiming; Hu, Yu; Li, Jingxia; Ding, Min; Lu, Yongju; Zhang, Dongyun; Yan, Yan; Song, Lun; Qu, Qingshan; Desai, Dhimant; Amin, Shantu; Huang, Chuanshu
2007 Oct;28(10):2218-2226, Carcinogenesis
— id: 75360, year: 2007, vol: 28, page: 2218, stat: Journal Article,

PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1
Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Jiang, Bing-Hua; Huang, Dr Chuanshu
2007 Jul 1;101(4):969-978, Journal of cellular biochemistry
— id: 73945, year: 2007, vol: 101, page: 969, stat: Journal Article,

Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells
Ouyang, Weiming; Ma, Qian; Li, Jingxia; Zhang, Dongyun; Ding, Jin; Huang, Yi; Xing, Mingzhao M; Huang, Chuanshu
2007 Jan;46(1):32-41, Molecular carcinogenesis
— id: 70301, year: 2007, vol: 46, page: 32, stat: Journal Article,

Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells
Ouyang, Weiming; Zhang, Dongyun; Ma, Qian; Li, Jingxia; Huang, Chuanshu
2007 Apr;115(4):513-518, Environmental health perspectives
— id: 72542, year: 2007, vol: 115, page: 513, stat: Journal Article,

[The activation of MAPK/cyclin D1-CDK4 signaling pathway caused by quartz]
Shen, Fu-Hai; Fan, Xue-Yun; Liu, Bing-Ci; Jia, Xiao-Wei; Gao, Ai; You, Bao-Rong; Ye, Meng; DU, Hong-Ju; Huang, Chuan-Shu; Shi, Xiang-Lin
2007 Jan;25(1):5-10, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene & occupational diseases
— id: 132265, year: 2007, vol: 25, page: 5, stat: Journal Article,

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation
Song, Lun; Li, Jingxia; Ye, Jianping; Yu, Gang; Ding, Jin; Zhang, Dongyun; Ouyang, Weiming; Dong, Zigang; Kim, Sung O; Huang, Chuanshu
2007 Apr;27(7):2713-2731, Molecular & cellular biology
— id: 71925, year: 2007, vol: 27, page: 2713, stat: Journal Article,

JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo
Song, Zibo; Tong, Chang; Liang, Jiao; Dockendorff, Ashley; Huang, Chuanshu; Augenlicht, Leonard H; Yang, Wancai
2007 Apr 10;560(2-3):95-100, European journal of pharmacology
— id: 106253, year: 2007, vol: 560, page: 95, stat: Journal Article,

Cancer prevention with freeze-dried berries and berry components
Stoner, Gary D; Wang, Li-Shu; Zikri, Nancy; Chen, Tong; Hecht, Stephen S; Huang, Chuanshu; Sardo, Christine; Lechner, John F
2007 Oct;17(5):403-410, Seminars in cancer biology
— id: 110426, year: 2007, vol: 17, page: 403, stat: Journal Article,

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
Tong, Chang; Yin, Zhinan; Song, Zibo; Dockendorff, Ashley; Huang, Chuanshu; Mariadason, John; Flavell, Richard A; Davis, Roger J; Augenlicht, Leonard H; Yang, Wancai
2007 Jul;171(1):297-303, American journal of pathology
— id: 106252, year: 2007, vol: 171, page: 297, stat: Journal Article,

JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
Zhang, Dongyun; Li, Jingxia; Wu, Kangjian; Ouyang, Weiming; Ding, Jin; Liu, Zheng-gang; Costa, Max; Huang, Chuanshu
2007 Apr;28(4):883-891, Carcinogenesis
— id: 68994, year: 2007, vol: 28, page: 883, stat: Journal Article,

High expression of nuclear factor of activated T cells in Chinese primary non-small cell lung cancer tissues
Zhang, K; Li, N; Chen, Z; Shao, K; Zhou, F; Zhang, C; Mu, X; Wan, J; Li, B; Feng, X; Shi, S; Xiong, M; Cao, K; Wang, X; Huang, C; He, J
2007 JUL-SEP ;22(3):221-225, International Journal of Biological Markers
— id: 75201, year: 2007, vol: 22, page: 221, stat: Journal Article,

The PI3K/Akt pathway and its downstream transcriptional factors as targets for chemoprevention
Zhang, Xinhai; Jin, Boquan; Huang, Chuanshu
2007 Jun;7(4):305-316, Current cancer drug targets
— id: 75481, year: 2007, vol: 7, page: 305, stat: Journal Article,

Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway
Ding, Jin; Li, Jingxia; Chen, Jingyuan; Chen, Haobin; Ouyang, Weiming; Zhang, Ronghe; Xue, Caifang; Zhang, Dongyun; Amin, Shantu; Desai, Dhimant; Huang, Chuanshu
2006 Apr 7;281(14):9093-9100, Journal of biological chemistry
— id: 64384, year: 2006, vol: 281, page: 9093, stat: Journal Article,

Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells
Ding, Jin; Li, Jingxia; Xue, Caifang; Wu, Kangjian; Ouyang, Weiming; Zhang, Dongyun; Yan, Yan; Huang, Chuanshu
2006 Aug 25;281(34):24405-24413, Journal of biological chemistry
— id: 69059, year: 2006, vol: 281, page: 24405, stat: Journal Article,

Involvement of nuclear factor of activated T cells 3 (NFAT3) in cyclin D1 induction by B[a]PDE or B[a]PDE and ionizing radiation in mouse epidermal Cl 41 cells
Ding, Jin; Zhang, Ronghe; Li, Jingxia; Xue, Caifang; Huang, Chuanshu
2006 Jul;287(1-2):117-125, Molecular & cellular biochemistry
— id: 110431, year: 2006, vol: 287, page: 117, stat: Journal Article,

Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway
Ding, Jin; Zhang, Xinhai; Li, Jingxia; Song, Lun; Ouyang, Weiming; Zhang, Dongyun; Xue, Caifang; Costa, Max; Melendez, J Andres; Huang, Chuanshu
2006 Dec;281(51):39022-39032, Journal of biological chemistry
— id: 156051, year: 2006, vol: 281, page: 39022, stat: Journal Article,

Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway
Ding, Min; Huang, Chuanshu; Lu, Yongju; Bowman, Linda; Castranova, Vince; Vallyathan, Val
2006 Feb;290(2):L291-L297, American journal of physiology. Lung cellular & molecular physiology
— id: 110434, year: 2006, vol: 290, page: L291, stat: Journal Article,

Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts
Du, Hong Ju; Tang, Ning; Liu, Bing Ci; You, Bao Rong; Shen, Fu Hai; Ye, Meng; Gao, Ai; Huang, Chuan shu
2006 Jul;287(1-2):79-89, Molecular & cellular biochemistry
— id: 132263, year: 2006, vol: 287, page: 79, stat: Journal Article,

[Vitamin C reverses benzo (a) pyrene-induced cell cycle changes by E2F pathway]
Gao, Ai; Liu, Bing-ci; Shen, Fu-hai; Du, Hong-ju; Huang, Chuan-shu; Jia, Xiao-wei; You, Bao-rong; Ye, Meng
2006 Mar;40(2):79-83, Zhonghua Yu Fang Yi Xue Za Zhi = Chinese journal of preventive medicine
— id: 132267, year: 2006, vol: 40, page: 79, stat: Journal Article,

Vitamin C inhibits benzo[a]pyrene-induced cell cycle changes partly via cyclin D1/E2F pathway in human embryo lung fibroblasts
Gao, Ai; Liu, Bing-Ci; Shit, Xiang-Lin; Huang, Chuan-Shu; Jia, Xiao-Wei; You, Bao-Rong; Ye, Meng; Shen, Fu-Hai; Du, Hong-Ju
2006 Jun;19(3):239-244, Biomedical & environmental sciences
— id: 132266, year: 2006, vol: 19, page: 239, stat: Journal Article,

Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity
Hecht, Stephen S; Huang, Chuanshu; Stoner, Gary D; Li, Jingxia; Kenney, Patrick M J; Sturla, Shana J; Carmella, Steven G
2006 Aug;27(8):1617-1626, Carcinogenesis
— id: 110432, year: 2006, vol: 27, page: 1617, stat: Journal Article,

Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway
Huang, Chuanshu; Li, Jingxia; Song, Lun; Zhang, Dongyun; Tong, Qiangsong; Ding, Min; Bowman, Linda; Aziz, Robeena; Stoner, Gary D
2006 Jan 1;66(1):581-587, Cancer research
— id: 62607, year: 2006, vol: 66, page: 581, stat: Journal Article,

Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure
Ke, Qingdong; Li, Jingxia; Ding, Jin; Ding, Min; Wang, Liying; Liu, Bingci; Costa, Max; Huang, Chuanshu
2006 Aug;291(2):L257-L264, American journal of physiology. Lung cellular & molecular physiology
— id: 68743, year: 2006, vol: 291, page: L257, stat: Journal Article,

NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 cells
Li, Jingxia; Lu, Haitian; Huang, Chuanshu
2006 Sep;289(1-2):73-82, Molecular & cellular biochemistry
— id: 110429, year: 2006, vol: 289, page: 73, stat: Journal Article,

Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells
Li, Jingxia; Song, Lun; Zhang, Dongyun; Wei, Lixin; Huang, Chuanshu
2006 Nov 1;99(4):1010-1020, Journal of cellular biochemistry
— id: 69573, year: 2006, vol: 99, page: 1010, stat: Journal Article,

Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
Lu, Bin; Wang, Liying; Stehlik, Christian; Medan, Djordje; Huang, Chuanshu; Hu, Shuiying; Chen, Fei; Shi, Xianglin; Rojanasakul, Yon
2006 Jun 1;176(11):6785-6793, Journal of immunology
— id: 110430, year: 2006, vol: 176, page: 6785, stat: Journal Article,

Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes
Lu, Haitian; Li, Jingxia; Zhang, Dongyun; Stoner, Gary D; Huang, Chuanshu
2006 ;54(1):69-78, Nutrition & cancer
— id: 69241, year: 2006, vol: 54, page: 69, stat: Journal Article,

Inflammation, a key event in cancer development
Lu, Haitian; Ouyang, Weiming; Huang, Chuanshu
2006 Apr;4(4):221-233, Molecular cancer research
— id: 64167, year: 2006, vol: 4, page: 221, stat: Journal Article,

Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells
Ouyang, Weiming; Li, Jingxia; Ma, Qian; Huang, Chuanshu
2006 Apr;27(4):864-873, Carcinogenesis
— id: 64132, year: 2006, vol: 27, page: 864, stat: Journal Article,

Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway
Shen, Fuhai; Fan, Xueyun; Liu, Bingci; Jia, Xiaowei; Du, Hongju; You, Baorong; Ye, Meng; Huang, Chuanshu; Shi, Xianglin
2006 Jan 25;160(3):185-195, Toxicology letters
— id: 110435, year: 2006, vol: 160, page: 185, stat: Journal Article,

IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response
Song, Lun; Li, Jingxia; Zhang, Dongyun; Liu, Zheng-Gang; Ye, Jianping; Zhan, Qimin; Shen, Han-Ming; Whiteman, Matt; Huang, Chuanshu
2006 Nov 20;175(4):607-617, Journal of cell biology
— id: 70092, year: 2006, vol: 175, page: 607, stat: Journal Article,

Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells
Tong, Qiangsong; Zheng, Liduan; Li, Bo; Wang, Danming; Huang, Chuanshu; Matuschak, George M; Li, Dechun
2006 Nov 1;312(18):3559-3569, Experimental cell research
— id: 110427, year: 2006, vol: 312, page: 3559, stat: Journal Article,

VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway
Tong, Qiangsong; Zheng, Liduan; Lin, Li; Li, Bo; Wang, Danming; Huang, Chuanshu; Li, Dechun
2006 ;7:37-37, Respiratory research
— id: 110433, year: 2006, vol: 7, page: 37, stat: Journal Article,

Participation of the PI-3K/Akt-NF-kappaB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells
Tong, Qiangsong; Zheng, Liduan; Lin, Li; Li, Bo; Wang, Danming; Huang, Chuanshu; Matuschak, George M; Li, Dechun
2006 ;7:101-101, Respiratory research
— id: 68805, year: 2006, vol: 7, page: 101, stat: Journal Article,

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells
Yan, Yan; Li, Jingxia; Ouyang, Weiming; Ma, Qian; Hu, Yu; Zhang, Dongyun; Ding, Jin; Qu, Qingshan; Subbaramaiah, Kotha; Huang, Chuanshu
2006 Jul 15;119(Pt 14):2985-2994, Journal of cell science
— id: 110428, year: 2006, vol: 119, page: 2985, stat: Journal Article,

Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B
Zhang, Dongyun; Lu, Haitian; Li, Jingxia; Shi, Xianglin; Huang, Chuanshu
2006 Dec;293(1-2):161-171, Molecular & cellular biochemistry
— id: 71140, year: 2006, vol: 293, page: 161, stat: Journal Article,

Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses
Zhang, Dongyun; Song, Lun; Li, Jingxia; Wu, Kangjian; Huang, Chuanshu
2006 Nov 10;281(45):34113-34123, Journal of biological chemistry
— id: 69592, year: 2006, vol: 281, page: 34113, stat: Journal Article,

Ionizing radiation synergistic induction of cyclooxygenase-2 with benzo[a]pyrene diol-epoxide through nuclear factor of activated T cells in mouse epidermal Cl 41 cells
Zhang, Ronghe; Li, Jingxia; Burns, Fredric J; Huang, Chuanshu
2006 Mar;15(3):721-727, Oncology reports
— id: 63739, year: 2006, vol: 15, page: 721, stat: Journal Article,

Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells
Chen, Jingyuan; Yan, Yan; Li, Jingxia; Ma, Qian; Stoner, Gary D; Ye, Jianping; Huang, Chuanshu
2005 Jun;26(6):1035-1043, Carcinogenesis
— id: 56052, year: 2005, vol: 26, page: 1035, stat: Journal Article,

Nickel carcinogenesis: epigenetics and hypoxia signaling
Costa, Max; Davidson, Todd L; Chen, Haobin; Ke, Qingdong; Zhang, Ping; Yan, Yan; Huang, Chuanshu; Kluz, Thomas
2005 Dec 30;592(1-2):79-88, Mutation research
— id: 67383, year: 2005, vol: 592, page: 79, stat: Journal Article,

ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells
Li, Jingxia; Tong, Qiangsong; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):25-33, Molecular & cellular biochemistry
— id: 70870, year: 2005, vol: 279, page: 25, stat: Journal Article,

Carcinogenic effect of nickel compounds
Lu, Haitian; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):45-67, Molecular & cellular biochemistry
— id: 70872, year: 2005, vol: 279, page: 45, stat: Journal Article,

The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivation
Ma, Cuiling; Bower, Kimberly A; Lin, Hong; Chen, Gang; Huang, Chuanshu; Shi, Xianglin; Luo, Jia
2005 Jun 15;69(12):1785-1794, Biochemical pharmacology
— id: 110436, year: 2005, vol: 69, page: 1785, stat: Journal Article,

Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression
Ouyang, Weiming; Li, Jingxia; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2005 Nov;279(1-2):35-43, Molecular & cellular biochemistry
— id: 70871, year: 2005, vol: 279, page: 35, stat: Journal Article,

Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes
Ouyang, Weiming; Ma, Qian; Li, Jingxia; Zhang, Dongyun; Liu, Zheng-Gang; Rustgi, Anil K; Huang, Chuanshu
2005 Oct 15;65(20):9287-9293, Cancer research
— id: 61269, year: 2005, vol: 65, page: 9287, stat: Journal Article,

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation
Wang, Jian; Ouyang, Weiming; Li, Jingxia; Wei, Lixin; Ma, Qian; Zhang, Zhuo; Tong, Qiangsong; He, Jie; Huang, Chuanshu
2005 Aug 1;65(15):6601-6611, Cancer research
— id: 62323, year: 2005, vol: 65, page: 6601, stat: Journal Article,

Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
Dai, Jisen; Huang, Chuanshu; Wu, Jing; Yang, Chengfeng; Frenkel, Krystyna; Huang, Xi
2004 Oct 15;203(1-3):199-209, Toxicology
— id: 47848, year: 2004, vol: 203, page: 199, stat: Journal Article,

Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract
Ding, Min; Lu, Yongju; Bowman, Linda; Huang, Chuanshu; Leonard, Stephen; Wang, Liying; Vallyathan, Val; Castranova, Vince; Shi, Xianglin
2004 Mar 12;279(11):10670-10676, Journal of biological chemistry
— id: 42694, year: 2004, vol: 279, page: 10670, stat: Journal Article,

Molecular mechanisms of arsenic carcinogenesis
Huang, Chuanshu; Ke, Qingdong; Costa, Max; Shi, Xianglin
2004 Jan;255(1-2):57-66, Molecular & cellular biochemistry
— id: 42693, year: 2004, vol: 255, page: 57, stat: Journal Article,

Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells
Li, Jingxia; Chen, Haobin; Ke, Qingdong; Feng, Zhaohui; Tang, Moon-Shong; Liu, Bingci; Amin, Shantu; Costa, Max; Huang, Chuanshu
2004 Jun;40(2):104-115, Molecular carcinogenesis
— id: 42690, year: 2004, vol: 40, page: 104, stat: Journal Article,

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
Li, Jingxia; Chen, Haobin; Tang, Moon-Shong; Shi, Xianglin; Amin, Shantu; Desai, Dhimant; Costa, Max; Huang, Chuanshu
2004 Apr 12;165(1):77-86, Journal of cell biology
— id: 42691, year: 2004, vol: 165, page: 77, stat: Journal Article,

Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells
Li, Jingxia; Davidson, Gerard; Huang, Yi; Jiang, Bing-Hua; Shi, Xianglin; Costa, Max; Huang, Chuanshu
2004 Jan 1;64(1):94-101, Cancer research
— id: 42615, year: 2004, vol: 64, page: 94, stat: Journal Article,

Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells
Li, Jingxia; Dokka, Sujatha; Wang, Liying; Shi, Xianglin; Castranova, Vincent; Yan, Yan; Costa, Max; Huang, Chuanshu
2004 Jan;255(1-2):217-225, Molecular & cellular biochemistry
— id: 42692, year: 2004, vol: 255, page: 217, stat: Journal Article,

A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells
Li, Jingxia; Tang, Moon-shong; Liu, Bingci; Shi, Xianglin; Huang, Chuanshu
2004 May 13;23(22):3932-3944, Oncogene
— id: 42695, year: 2004, vol: 23, page: 3932, stat: Journal Article,

The role of phosphatidylinositol-3 kinase in vanadate-promoted S phase entry
Zhang, Zhuo; Gao, Ning; He, Hengjun; Huang, Chuanshu; Jiang, Bing-hua; Jia, Luo; Shi, Xianglin
2004 Jan;255(1-2):239-245, Molecular & cellular biochemistry
— id: 42696, year: 2004, vol: 255, page: 239, stat: Journal Article,

Vanadate activated Akt and promoted S phase entry
Zhang, Zhuo; Gao, Ning; He, Hengjun; Huang, Chuanshu; Luo, Jia; Shi, Xianglin
2004 Jan;255(1-2):227-237, Molecular & cellular biochemistry
— id: 42697, year: 2004, vol: 255, page: 227, stat: Journal Article,

Deferoxamine synergistically enhancing iron-induced stimulation of activator protein-1 through increased ERKs phosphorylation
Dai, J; Huang, C; Huang, X
2003 MAR ;72(1):270-271, Toxicological sciences
— id: 38504, year: 2003, vol: 72, page: 270, stat: Journal Article,

Regulation of HIF transactivation and CAP43 expression by nickel compounds through PI-3K/AKT dependent, P70S6K-independent pathway
Davidson, G; Li, J; Huang, Y; Costa, M; Huang, C
2003 MAR ;72(1):106-106, Toxicological sciences
— id: 38494, year: 2003, vol: 72, page: 106, stat: Journal Article,

Deferoxamine synergistically enhances iron-induced stimulation of activator protein-1: Kinase activation versus phosphatase inhibition
Huang, X; Dai, JS; Zhang, Q; Huang, CS
2003 OCT ;35(11):S66-S66, Free radical biology & medicine
— id: 55392, year: 2003, vol: 35, page: S66, stat: Journal Article,

Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA
Li, Jingxia; Ma, Cuiling; Huang, Yi; Luo, Jia; Huang, Chuanshu
2003 Jan 16;22(2):211-219, Oncogene
— id: 39329, year: 2003, vol: 22, page: 211, stat: Journal Article,

Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro
Luo, Jia; Sun, Yanbo; Lin, Hong; Qian, Yong; Li, Zheng; Leonard, Stephen S; Huang, Chuanshu; Shi, Xianglin
2003 Feb 14;278(7):4542-4551, Journal of biological chemistry
— id: 38410, year: 2003, vol: 278, page: 4542, stat: Journal Article,

Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
Wang, Liying; Medan, Djordje; Mercer, Robert; Overmiller, Dean; Leornard, Stephen; Castranova, Vincent; Shi, Xianglin; Ding, Min; Huang, Chuanshu; Rojanasakul, Yon
2003 Apr;195(1):99-107, Journal of cellular physiology
— id: 38408, year: 2003, vol: 195, page: 99, stat: Journal Article,

Role of reactive oxygen species and MAPKs in vanadate-induced G(2)/M phase arrest
Zhang, Zhuo; Leonard, Stephen S; Huang, Chuanshu; Vallyathan, Val; Castranova, Vince; Shi, Xianglin
2003 May 15;34(10):1333-1342, Free radical biology & medicine
— id: 38407, year: 2003, vol: 34, page: 1333, stat: Journal Article,

Differential role of hydrogen peroxide in UV-induced signal transduction
Ding, Min; Li, Jingxia; Leonard, Stephen S; Shi, Xianglin; Costa, Max; Castranova, Vincent; Vallyathan, Val; Huang, Chuanshu
2002 May-Jun;234-235(1-2):81-90, Molecular & cellular biochemistry
— id: 38402, year: 2002, vol: 234-235, page: 81, stat: Journal Article,

Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts
Huang, Chuanshu; Huang, Yi; Li, Jingxia; Hu, Wenwei; Aziz, Robeena; Tang, Moon-shong; Sun, Nanjun; Cassady, John; Stoner, Gary D
2002 Dec 1;62(23):6857-6863, Cancer research
— id: 38406, year: 2002, vol: 62, page: 6857, stat: Journal Article,

Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C
Huang, Chuanshu; Li, Jingxia; Ke, Qingdong; Leonard, Stephen S; Jiang, Bing-Hua; Zhong, Xiao-Song; Costa, Max; Castranova, Vincent; Shi, Xianglin
2002 Oct 15;62(20):5689-5697, Cancer research
— id: 38401, year: 2002, vol: 62, page: 5689, stat: Journal Article,

Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts
Huang, Chuanshu; Li, Jingxia; Zhang, Qi; Huang, Xi
2002 Nov;27(5):568-574, American journal of respiratory cell & molecular biology
— id: 38471, year: 2002, vol: 27, page: 568, stat: Journal Article,

Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds
Huang, Yi; Davidson, Gerard; Li, Jingxia; Yan, Yan; Chen, Fei; Costa, Max; Chen, Lung Chi; Huang, Chuanshu
2002 Oct;110 Suppl 5(4):835-839, Environmental health perspectives
— id: 38400, year: 2002, vol: 110 Suppl 5, page: 835, stat: Journal Article,

Involvement of hydrogen peroxide in asbestos-induced NFAT activation
Li, Jingxia; Huang, Bihui; Shi, Xianglin; Castranova, Vincent; Vallyathan, Val; Huang, Chuanshu
2002 May-Jun;234-235(1-2):161-168, Molecular & cellular biochemistry
— id: 38414, year: 2002, vol: 234-235, page: 161, stat: Journal Article,

Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages
Lu, Bin; Wang, Liying; Medan, Djordje; Toledo, David; Huang, Chuanshu; Chen, Fei; Shi, Xianglin; Rojanasakul, Yon
2002 Sep;283(3):C831-C838, American journal of physiology. Cell physiology
— id: 38413, year: 2002, vol: 283, page: C831, stat: Journal Article,

Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis
She, Qing-Bai; Huang, Chuanshu; Zhang, Yiguo; Dong, Zigang
2002 Apr;33(4):244-250, Molecular carcinogenesis
— id: 38422, year: 2002, vol: 33, page: 244, stat: Journal Article,

Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice
Wang, Liying; Medan, Djordje; Mercer, Robert; Shi, Xianglin; Huang, Chuanshu; Castranova, Vincent; Ding, Min; Rojanasakul, Yon
2002 ;21(4):343-350, Journal of environmental pathology, toxicology & oncology
— id: 38409, year: 2002, vol: 21, page: 343, stat: Journal Article,

Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblasts
Zhang, Zhuo; Chen, Fei; Huang, Chuanshu; Shi, Xianglin
2002 ;21(3):223-231, Journal of environmental pathology, toxicology & oncology
— id: 38411, year: 2002, vol: 21, page: 223, stat: Journal Article,

MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cells
Zhang, Zhuo; He, Hengjuan; Chen, Fei; Huang, Chuanshu; Shi, Xianglin
2002 Jul;15(7):950-956, Chemical research in toxicology
— id: 38415, year: 2002, vol: 15, page: 950, stat: Journal Article,

Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells
Zhang, Zhuo; Huang, Chuanshu; Li, Jinxia; Shi, Xianglin
2002 Apr 10;89(1-2):142-148, Journal of inorganic biochemistry
— id: 38416, year: 2002, vol: 89, page: 142, stat: Journal Article,

Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathways
Zhu, Yunfeng; Wang, Mei; Lin, Hong; Huang, Chuanshu; Shi, Xianglin; Luo, Jia
2002 Oct 15;280(1):97-106, Experimental cell research
— id: 38412, year: 2002, vol: 280, page: 97, stat: Journal Article,

Role of N-acylethanolamines in cell signaling
Berdyshev EV; Schmid PC; Krebsbach RJ; Kuwae T; Huang C; Ma WY; Dong Z; Schmid HH
2001 ;88(2):207-214, World review of nutrition & dietetics
— id: 42699, year: 2001, vol: 88, page: 207, stat: Journal Article,

Cannabinoid-receptor-independent cell signalling by N-acylethanolamines
Berdyshev, E V; Schmid, P C; Krebsbach, R J; Hillard, C J; Huang, C; Chen, N; Dong, Z; Schmid, H H
2001 Nov 15;360(Pt 1):67-75, Biochemical journal
— id: 106269, year: 2001, vol: 360, page: 67, stat: Journal Article,

Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells
Ding M; Shi X; Lu Y; Huang C; Leonard S; Roberts J; Antonini J; Castranova V; Vallyathan V
2001 Mar 23;276(12):9108-9114, Journal of biological chemistry
— id: 38419, year: 2001, vol: 276, page: 9108, stat: Journal Article,

Effects of tea polyphenols on the signal transduction pathways
Dong Z; Nomura M; Huang C; Ma WY
2001 ;492(2):55-67, Advances in experimental medicine & biology
— id: 42700, year: 2001, vol: 492, page: 55, stat: Journal Article,

Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate
Huang C; Bode AM; Chen NY; Ma WY; Li J; Nomura M; Dong Z
2001 Jan-Feb;21(1A):261-267, Anticancer research
— id: 42701, year: 2001, vol: 21, page: 261, stat: Journal Article,

Vanadium-induced nuclear factor of activated T cells activation through hydrogen peroxide
Huang C; Ding M; Li J; Leonard SS; Rojanasakul Y; Castranova V; Vallyathan V; Ju G; Shi X
2001 Jun 22;276(25):22397-22403, Journal of biological chemistry
— id: 21209, year: 2001, vol: 276, page: 22397, stat: Journal Article,

Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide
Huang C; Li J; Costa M; Zhang Z; Leonard SS; Castranova V; Vallyathan V; Ju G; Shi X
2001 Nov 15;61(22):8051-8057, Cancer research
— id: 26560, year: 2001, vol: 61, page: 8051, stat: Journal Article,

Transactivation of RARE and GRE in the cellular response to arsenic
Huang C; Li J; Ding M; Costa M; Castranova V; Vallyathan V; Ju G; Shi X
2001 Jun;222(1-2):119-125, Molecular & cellular biochemistry
— id: 38405, year: 2001, vol: 222, page: 119, stat: Journal Article,

UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide
Huang C; Li J; Ding M; Leonard SS; Wang L; Castranova V; Vallyathan V; Shi X
2001 Oct 26;276(43):40234-40240, Journal of biological chemistry
— id: 26594, year: 2001, vol: 276, page: 40234, stat: Journal Article,

Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells
Huang C; Li J; Ding M; Wang L; Shi X; Castranova V; Vallyathan V; Ju G; Costa M
2001 Jun;222(1-2):29-34, Molecular & cellular biochemistry
— id: 38403, year: 2001, vol: 222, page: 29, stat: Journal Article,

Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation
Huang C; Ma WY; Ding M; Li J; Shi X; Castranova V; Vallyathan V; Bode AM; Dong Z
2001 Apr;15(6):1113-1114, FASEB journal
— id: 38418, year: 2001, vol: 15, page: 1113, stat: Journal Article,

Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo
Huang C; Zhang Q; Li J; Shi X; Castranova V; Ju G; Costa M; Dong Z
2001 Jun;222(1-2):141-147, Molecular & cellular biochemistry
— id: 38404, year: 2001, vol: 222, page: 141, stat: Journal Article,

Vanadate-induced cell growth regulation and the role of reactive oxygen species
Zhang Z; Huang C; Li J; Leonard SS; Lanciotti R; Butterworth L; Shi X
2001 Aug 15;392(2):311-320, Archives of biochemistry & biophysics. ABB
— id: 38417, year: 2001, vol: 392, page: 311, stat: Journal Article,

Activation of PKC is required for arsenite-induced signal transduction
Chen NY; Ma WY; Huang C; Ding M; Dong Z
2000 ;19(3):297-305, Journal of environmental pathology, toxicology & oncology
— id: 42702, year: 2000, vol: 19, page: 297, stat: Journal Article,

Free radical-mediated transgene inactivation of macrophages by endotoxin
Dokka S; Toledo D; Wang L; Shi X; Huang C; Leonard S; Rojanasakul Y
2000 Nov;279(5):L878-L883, American journal of physiology. Lung cellular & molecular physiology
— id: 38420, year: 2000, vol: 279, page: L878, stat: Journal Article,

Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation
Huang C; Li J; Chen N; Ma W; Bowden GT; Dong Z
2000 Feb;27(2):65-75, Molecular carcinogenesis
— id: 42720, year: 2000, vol: 27, page: 65, stat: Journal Article,

Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice
Huang C; Mattjus P; Ma WY; Rincon M; Chen NY; Brown RE; Dong Z
2000 Mar 31;275(13):9143-9149, Journal of biological chemistry
— id: 34184, year: 2000, vol: 275, page: 9143, stat: Journal Article,

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis
Huang C; Zhang Z; Ding M; Li J; Ye J; Leonard SS; Shen HM; Butterworth L; Lu Y; Costa M; Rojanasakul Y; Castranova V; Vallyathan V; Shi X
2000 Oct 20;275(42):32516-32522, Journal of biological chemistry
— id: 34185, year: 2000, vol: 275, page: 32516, stat: Journal Article,

Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse
Huang, W J; Wang, B R; Yao, L B; Huang, C S; Wang, X; Zhang, P; Jiao, X Y; Duan, X L; Chen, B F; Ju, G
2000 Apr 7;861(1):181-185, Brain research
— id: 106251, year: 2000, vol: 861, page: 181, stat: Journal Article,

Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea
Nomura M; Ma WY; Huang C; Yang CS; Bowden GT; Miyamoto K; Dong Z
2000 Jul;28(3):148-155, Molecular carcinogenesis
— id: 42703, year: 2000, vol: 28, page: 148, stat: Journal Article,

Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis
Chen N; Ma W; Huang C; Dong Z
1999 May 28;274(22):15389-15394, Journal of biological chemistry
— id: 42726, year: 1999, vol: 274, page: 15389, stat: Journal Article,

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved
Chung JY; Huang C; Meng X; Dong Z; Yang CS
1999 Sep 15;59(18):4610-4617, Cancer research
— id: 42724, year: 1999, vol: 59, page: 4610, stat: Journal Article,

PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer
Dong Z; Huang C; Ma WY
1999 Sep-Oct;19(5A):3743-3747, Anticancer research
— id: 42704, year: 1999, vol: 19, page: 3743, stat: Journal Article,

JNK activation is required for JB6 cell transformation induced by tumor necrosis factor-alpha but not by 12-O-tetradecanoylphorbol-13-acetate
Huang C; Li J; Ma WY; Dong Z
1999 Oct 15;274(42):29672-29676, Journal of biological chemistry
— id: 34183, year: 1999, vol: 274, page: 29672, stat: Journal Article,

The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells
Huang C; Ma WY; Dong Z
1999 May 6;18(18):2828-2835, Oncogene
— id: 42706, year: 1999, vol: 18, page: 2828, stat: Journal Article,

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
Huang C; Ma WY; Goranson A; Dong Z
1999 Feb;20(2):237-242, Carcinogenesis
— id: 42698, year: 1999, vol: 20, page: 237, stat: Journal Article,

Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway
Huang C; Ma WY; Li J; Dong Z
1999 Jul 1;59(13):3053-3058, Cancer research
— id: 42705, year: 1999, vol: 59, page: 3053, stat: Journal Article,

Requirement of Erk, but not JNK, for arsenite-induced cell transformation
Huang C; Ma WY; Li J; Goranson A; Dong Z
1999 May 21;274(21):14595-14601, Journal of biological chemistry
— id: 34182, year: 1999, vol: 274, page: 14595, stat: Journal Article,

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
Huang C; Ma WY; Maxiner A; Sun Y; Dong Z
1999 Apr 30;274(18):12229-12235, Journal of biological chemistry
— id: 34181, year: 1999, vol: 274, page: 12229, stat: Journal Article,

The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB
Shi X; Dong Z; Huang C; Ma W; Liu K; Ye J; Chen F; Leonard SS; Ding M; Castranova V; Vallyathan V
1999 Apr;194(1-2):63-70, Molecular & cellular biochemistry
— id: 38421, year: 1999, vol: 194, page: 63, stat: Journal Article,

Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation
Barthelman M; Chen W; Gensler HL; Huang C; Dong Z; Bowden GT
1998 Feb 15;58(4):711-716, Cancer research
— id: 42721, year: 1998, vol: 58, page: 711, stat: Journal Article,

Increased synthesis of phosphocholine is required for UV-induced AP-1 activation
Dong Z; Huang C; Ma WY; Malewicz B; Baumann WJ; Kiss Z
1998 Oct 8;17(14):1845-1853, Oncogene
— id: 42707, year: 1998, vol: 17, page: 1845, stat: Journal Article,

Vanadium induces AP-1- and NFkappB-dependent transcription activity
Huang C; Chen N; Ma WY; Dong Z
1998 Oct;13(4):711-715, International journal of oncology
— id: 42708, year: 1998, vol: 13, page: 711, stat: Journal Article,

Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C epsilon
Huang C; Ma WY; Dong Z
1998 Mar;10(3):185-190, Cellular signalling
— id: 42709, year: 1998, vol: 10, page: 185, stat: Journal Article,

Essential role of p53 in phenethyl isothiocyanate-induced apoptosis
Huang C; Ma WY; Li J; Hecht SS; Dong Z
1998 Sep 15;58(18):4102-4106, Cancer research
— id: 34180, year: 1998, vol: 58, page: 4102, stat: Journal Article,

Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells
Huang C; Ma WY; Young MR; Colburn N; Dong Z
1998 Jan 6;95(1):156-161, Proceedings of the National Academy of Sciences of the United States of America
— id: 34179, year: 1998, vol: 95, page: 156, stat: Journal Article,

Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase
Ma WY; Huang C; Dong Z
1998 Mar;12(3):565-568, International journal of oncology
— id: 42710, year: 1998, vol: 12, page: 565, stat: Journal Article,

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation
Watts RG; Huang C; Young MR; Li JJ; Dong Z; Pennie WD; Colburn NH
1998 Dec 31;17(26):3493-3498, Oncogene
— id: 42728, year: 1998, vol: 17, page: 3493, stat: Journal Article,

Plasticity of GAP-43 innervation of the spleen during immune response in the mouse. Evidence for axonal sprouting and redistribution of the nerve fibers
Yang, H; Wang, L; Huang, C S; Ju, G
1998 Jan-Apr;5(1-2):53-60, Neuroimmunomodulation
— id: 106270, year: 1998, vol: 5, page: 53, stat: Journal Article,

Inhibition of activator protein 1 activity and neoplastic transformation by aspirin
Dong Z; Huang C; Brown RE; Ma WY
1997 Apr 11;272(15):9962-9970, Journal of biological chemistry
— id: 42715, year: 1997, vol: 272, page: 9962, stat: Journal Article,

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins
Dong Z; Ma W; Huang C; Yang CS
1997 Oct 1;57(19):4414-4419, Cancer research
— id: 42725, year: 1997, vol: 57, page: 4414, stat: Journal Article,

Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase
Huang C; Ma W; Ding M; Bowden GT; Dong Z
1997 Oct 31;272(44):27753-27757, Journal of biological chemistry
— id: 42722, year: 1997, vol: 272, page: 27753, stat: Journal Article,

Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells
Huang C; Ma W; Dong Z
1997 Apr 24;14(16):1945-1954, Oncogene
— id: 42727, year: 1997, vol: 14, page: 1945, stat: Journal Article,

Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid
Huang C; Ma WY; Dawson MI; Rincon M; Flavell RA; Dong Z
1997 May 27;94(11):5826-5830, Proceedings of the National Academy of Sciences of the United States of America
— id: 42714, year: 1997, vol: 94, page: 5826, stat: Journal Article,

Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice
Huang C; Ma WY; Hanenberger D; Cleary MP; Bowden GT; Dong Z
1997 Oct 17;272(42):26325-26331, Journal of biological chemistry
— id: 42712, year: 1997, vol: 272, page: 26325, stat: Journal Article,

Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase
Huang C; Ma WY; Hecht SS; Dong Z
1997 Jul 15;57(14):2873-2878, Cancer research
— id: 42713, year: 1997, vol: 57, page: 2873, stat: Journal Article,

Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase
Huang C; Ma WY; Ryan CA; Dong Z
1997 Oct 28;94(22):11957-11962, Proceedings of the National Academy of Sciences of the United States of America
— id: 42711, year: 1997, vol: 94, page: 11957, stat: Journal Article,

Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation
Huang C; Schmid PC; Ma WY; Schmid HH; Dong Z
1997 Feb 14;272(7):4187-4194, Journal of biological chemistry
— id: 42716, year: 1997, vol: 272, page: 4187, stat: Journal Article,

Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKClambda/iota
Huang C; Ma W; Bowden GT; Dong Z
1996 Dec 6;271(49):31262-31268, Journal of biological chemistry
— id: 42723, year: 1996, vol: 271, page: 31262, stat: Journal Article,

Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
Huang C; Ma WY; Dong Z
1996 Nov;16(11):6427-6435, Molecular & cellular biology
— id: 42717, year: 1996, vol: 16, page: 6427, stat: Journal Article,

Inhibitory effects of ascorbic acid on AP-1 activity and transformation of JB6 cells
Huang, CS; Ma, WY; Dong, ZG
1996 FEB ;8(2):389-393, International journal of oncology
— id: 106289, year: 1996, vol: 8, page: 389, stat: Journal Article,

Hemorrhagic fever with renal syndrome: relationship between pathogenesis and cellular immunity
Huang, C; Jin, B; Wang, M; Li, E; Sun, C
1994 Apr;169(4):868-870, Journal of infectious diseases
— id: 106249, year: 1994, vol: 169, page: 868, stat: Journal Article,

The effects of hybridoma growth factor in conditioned media upon the growth, cloning, and antibody production of heterohybridoma cell lines
Zhu, Y; Jin, B; Sun, C; Huang, C; Liu, X
1993 Jan;4(1):31-35, Human antibodies & hybridomas
— id: 106248, year: 1993, vol: 4, page: 31, stat: Journal Article,

Activation of corticotropin-releasing factor-containing neurons in the paraventricular nucleus of the hypothalamus by interleukin-1 in the rat
Ju, G; Zhang, X; Jin, B Q; Huang, C S
1991 Nov 11;132(2):151-154, Neuroscience letters
— id: 106247, year: 1991, vol: 132, page: 151, stat: Journal Article,