Douglas Scott Holmes

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Douglas Scott Holmes, M.D.

Assistant Professor;
Departments of Medicine (Cardio Div) and Pediatrics (Administration)
NYU Electrophysiology
NYU EKG Associates

Clinical Addresses

HEART RHYTHM CENTER
403 EAST 34TH STREET, 4TH FLOOR
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-3600
Fax: 212-263-0625

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Medical Specialties

Cardiology

Medical Expertise

Electrophysiology, Arrhythmia, Atrial Fibril./Arrhythmia Surg, Pacemaker/Aicd

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, CIGNA EPO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, FIDELIS CHLD HLTH, FIDELIS EXCHANGE, FIDELIS FAM HLTH, FIDELIS MEDICARE, Fidelis Medicaid, GHI CBP, HEALTHPLUS CHLD HLTH (AMERIGROUP), HEALTHPLUS FAM HLTH (AMERIGROUP), HEALTHPLUS MEDICAID (AMERIGROUP), HEALTHREPUBLIC, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP FAM HLTH, HIP HMO, HIP MEDICAID, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, METROPLUS CHLD HLTH, METROPLUS EXCHANGE PLANS, METROPLUS FAM HLTH, MULTIPLAN/PHCS PPO, Medicare, MetroPlus Medicaid, NY MEDICAID, NYS EMPIRE PLAN, OSCAR, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare Tricare, UHC COMMUNITY & STATE PLAN, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Education

1992 — Columbia University College of Physicians & Surgeons, Medical Education
1992-1995 — NYU Medical Center, Residency Training
1995-1998 — NYU Medical Center (Cardiology), Clinical Fellowships
1998-1999 — NYU Medical Center (Cardiac Electrophysi), Clinical Fellowships

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Research Summary

Atrial fibrillation (AF) is the most common clinical arrhythmia seen and results in significant morbidity and mortality. As a result, there is tremendous interest in understanding the mechanisms leading to and supporting AF. Clinically, AF starts with ectopic atrial activity originating from the pulmonary veins or the body of the left atrium. Should these atrial beats coincide with a vulnerable atrial substrate able to support multiple wavelet reentry, AF results. While there are currently no good animal models to study ectopic atrial activity, an atrial tachy-paced model is used to study the atrial changes resulting from high frequency electrical activity. While this model recapitulates many of the features of clinical AF, it also has numerous shortcomings. More recently, it has been observed that following congestive heart failure, atrial structures dilate and are thus susceptible to AF initiation. This model is more closely related to human pathophysiology. We are using a rabbit model of myocardial infarction to study the cellular changes induced by pressure overload atrial dilation.

At the cellular level, we are investigating the electrophysiologic alterations underlying abnormal automaticity and triggered activity. Failing cardiac tissues undergo remodeling of their ion handling proteins characterized by up or down regulation of protein expression. In general, these changes tend to amplify subthreshold electrical events into triggered activity. While the mechanisms behind ventricular ectopy have become well characterized, those of the atrium are less well understood. Among the differences between atrial and ventricular cells is the presence of IP3 receptors in atrial tissue. These calcium-releasing receptors are up regulated in failing atrium and may play a role in both triggered activity within the atrial free wall and abnormal automaticity from spontaneously firing cells within the pulmonary veins. Using confocal microscopy and patch clamp techniques, in a collaboration with the laboratory of Dr. William Coetzee and Michael Artman, we simultaneously measure subcellular calcium transients and sarcolemmal membrane currents. Interactions between excitation-contraction mechanisms and IP3 calcium release could form the basis of new atrial specific therapeutic targeting.

Research Interests

Understanding the cellular mechanisms underlying cardiac arrhythmias and sudden death. New therapies in the treatment of Atrial Fibrillation.<br>

Research Keywords

Electrophysiology, Sudden death, Atrial fibrillation, T-Wave Alternants, Cardiac Calcium physiology.

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Atrial fibrillation ablation in patients with known sludge in the left atrial appendage
Hajjiri, Mohammed; Bernstein, Scott; Saric, Muhamed; Benenstein, Ricardo; Aizer, Anthony; Dym, Glenn; Fowler, Steven; Holmes, Douglas; Bernstein, Neil; Mascarenhas, Mark; Park, David; Chinitz, Larry
2014 Apr;:147-151, Journal of interventional cardiac electrophysiology
— id: 909162, year: 2014, vol: , page: 147, stat: Journal Article,

The Role of Multimodality Imaging in Percutaneous Left Atrial Appendage Suture Ligation with the LARIAT Device
Laura, Diana M; Chinitz, Larry A; Aizer, Anthony; Holmes, Douglas S; Benenstein, Ricardo; Freedberg, Robin S; Kim, Eugene E; Saric, Muhamed
2014 May;:164-169, Journal of the American Society of Echocardiography
— id: 1018862, year: 2014, vol: , page: 164, stat: Journal Article,

The benign nature of mild induced therapeutic hypothermia-Induced long QTc
Weitz, Daniel; Greet, Brian; Bernstein, Scott A; Holmes, Douglas S; Bernstein, Neil; Aizer, Anthony; Chinitz, Larry; Roswell, Robert O
2013 Feb;:1583-1585, International journal of cardiology
— id: 395462, year: 2013, vol: , page: 1583, stat: Journal Article,

Narrow complex tachycardia with cycle length variability-what is the mechanism?
Aizer, A; Holmes, DS; Fowler, SJ; Chinitz, LA
2012 Apr;:1335-1337, Heart rhythm
— id: 161151, year: 2012, vol: , page: 1335, stat: Journal Article,

Right-Sided Implantation and Subpectoral Position are Predisposing Factors for Fracture of a 6.6 French ICD Lead
Bernstein, Neil E; Karam, Edmund T; Aizer, Anthony; Wong, Brian C; Holmes, Douglas S; Bernstein, Scott A; Chinitz, Larry A
2012 Jun;35(6):659-664, Pacing & clinical electrophysiology
— id: 169243, year: 2012, vol: 35, page: 659, stat: Journal Article,

Spinal cord stimulation protects against tachypacing-induced atrial fibrillation
Bernstein, S A; Wong, B; Vasquez, C; Rosenberg, S P; Rooke, R; Kuznekoff, L; Lader, J M; Mahoney, V M; Budylin, T; Alvstrand, M; Rakowski-Anderson, T; Bharmi, R; Shah, R; Fowler, S; Holmes, D; Farazi, T G; Chinitz, L A; Morley, G E
2012 May 2012;9(5):S443-S443, Heart rhythm
— id: 166946, year: 2012, vol: 9, page: S443, stat: Journal Article,

Spinal cord stimulation protects against atrial fibrillation induced by tachypacing
Bernstein, Scott A; Wong, Brian; Vasquez, Carolina; Rosenberg, Stuart P; Rooke, Ryan; Kuznekoff, Laura M; Lader, Joshua M; Mahoney, Vanessa M; Budylin, Tatyana; Alvstrand, Marie; Rakowski-Anderson, Tammy; Bharmi, Rupinder; Shah, Riddhi; Fowler, Steven; Holmes, Douglas; Farazi, Taraneh G; Chinitz, Larry A; Morley, Gregory E
2012 Sep;9(9):1426-33.e3, Heart rhythm
— id: 177139, year: 2012, vol: 9, page: 1426, stat: Journal Article,

Clinical Comparison of ICD Detection Algorithms that Include Rapid-VT Zones
Hirsh, David S; Chinitz, Larry A; Bernstein, Neil E; Holmes, Douglas S; Rao, Satya; Aizer, Anthony
2012 Oct;35(10):1222-1231, Pacing & clinical electrophysiology
— id: 179072, year: 2012, vol: 35, page: 1222, stat: Journal Article,

Spinal cord stimulation prevents tachypacing-induced atrial fibrillation
Bernstein S.A.; Wong B.; Holmes D.S.; Kuznekoff L.M.; Rooke R.; Alvstrand M.; Vasquez C.; Bharmi R.; Shah R.; Rosenberg S.P.; Farazi T.G.; Chinitz L.; Morley G.E.
2011 ;8(5 SUPPL 1):S330-S330, Heart rhythm
— id: 131860, year: 2011, vol: 8, page: S330, stat: Journal Article,

Contact sensing provides a highly accurate means to titrate radiofrequency ablation lesion depth
Holmes, Douglas; Fish, Jeffrey M; Byrd, Israel A; Dando, Jeremy D; Fowler, Steven J; Cao, Hong; Jensen, James A; Puryear, Harry A; Chinitz, Larry A
2011 Jun;22(6):684-690, Journal of cardiovascular electrophysiology
— id: 136471, year: 2011, vol: 22, page: 684, stat: Journal Article,

Meta-analysis to assess the appropriate endpoint for slow pathway ablation of atrioventricular nodal reentrant tachycardia
Stern, Joshua D; Rolnitzky, Linda; Goldberg, Judith D; Chinitz, Larry A; Holmes, Douglas S; Bernstein, Neil E; Bernstein, Scott A; Khairy, Paul; Aizer, Anthony
2011 Mar;34(3):269-277, Pacing & clinical electrophysiology
— id: 132603, year: 2011, vol: 34, page: 269, stat: Journal Article,

A novel mechanism of failure to detect atrial arrhythmias by pacemakers and implantable cardioverter defibrillators
Rose, Emily; Chinitz, Larry A; Holmes, Douglas S; Aizer, Anthony
2010 Mar;21(3):325-328, Journal of cardiovascular electrophysiology
— id: 133300, year: 2010, vol: 21, page: 325, stat: Journal Article,

Right-sided implantation and subpectoral position are predisposing factors for fidelis lead fractures
Bernstein N.E.; Karam E.T.; Wong B.; Aizer A.; Holmes D.S.; Bernstein S.A.; Chinitz L.A.
2009 ;6(5 SUPPL 1):S192-S192, Heart rhythm
— id: 131855, year: 2009, vol: 6, page: S192, stat: Journal Article,

Clinical comparison of ICD detection algorithms that include rapid VT zones
Hirsh D.; Bernstein N.E.; Holmes D.S.; Chinitz L.A.; Rao S.; Aizer A.
2009 ;6(5 SUPPL 1):S184-S185, Heart rhythm
— id: 131854, year: 2009, vol: 6, page: S184, stat: Journal Article,

Purkinje fiber-mediated idiopathic ventricular fibrillation mapping to left ventricular diverticulum
Shin W.S.; Karam E.; Aizer A.; Holmes D.S.; Bernstein N.E.; Chinitz L.A.
2009 ;6(5 SUPPL 1):S88-S89, Heart rhythm
— id: 131851, year: 2009, vol: 6, page: S88, stat: Journal Article,

Standardization and validation of an automated algorithm to identify fractionation as a guide for atrial fibrillation ablation
Aizer, Anthony; Holmes, Douglas S; Garlitski, Ann C; Bernstein, Neil E; Smyth-Melsky, Jane M; Ferrick, Aileen M; Chinitz, Larry A
2008 Aug;5(8):1134-1141, Heart rhythm
— id: 89057, year: 2008, vol: 5, page: 1134, stat: Journal Article,

Evaluation of the accuracy of a microprocessor-assisted cardiac rhythm algorithm in the interpretation of paced electrocardiograms
Garlitski, A; Bernstein, N; Aizer, A; Holmes, D; Chinitz, L
2007 OCT ;18(7):S101-S102, Journal of cardiovascular electrophysiology
— id: 75695, year: 2007, vol: 18, page: S101, stat: Journal Article,

Challenging icd programming in a patient with catecholaminergic polymorphic ventricular tachycardia
Garlitski, A; Swingle, J; Holmes, D; Aizer, A; Bernstein, N; Chinitz, L
2007 OCT ;18(7):S90-S90, Journal of cardiovascular electrophysiology
— id: 75694, year: 2007, vol: 18, page: S90, stat: Journal Article,

Irregular junctional rhythm masquerading as chronic atrial fibrillation
Garlitski, A; Swinlge, J; Holmes, D; Aizer, A; Bernstein, N; Chinitz, L
2007 OCT ;18(7):S73-S73, Journal of cardiovascular electrophysiology
— id: 75693, year: 2007, vol: 18, page: S73, stat: Journal Article,

Percutaneous treatment of the superior vena cava syndrome via an excimer laser sheath in a patient with a single chamber atrial pacemaker
Garlitski, Ann C; Swingle, Jad D; Aizer, Anthony; Holmes, Douglas S; Bernstein, Neil E; Chinitz, Larry A
2006 Sep;16(3):203-206, Journal of interventional cardiac electrophysiology
— id: 71862, year: 2006, vol: 16, page: 203, stat: Journal Article,

The Cornell Service Index as a measure of health service use
Sirey, Jo Anne; Meyers, Barnett S; Teresi, Jeanne A; Bruce, Martha L; Ramirez, Mildred; Raue, Patrick J; Perlick, Deborah A; Holmes, Douglas
2005 Dec;56(12):1564-1569, Psychiatric services
— id: 126950, year: 2005, vol: 56, page: 1564, stat: Journal Article,

Pulmonary vein isolation during minimally invasive mitral valve surgery: One-year follow-up
Mirchandani, S; Holmes, DS; Chinitz, LA; Bernstein, NE; Applebaum, RM; Colvin, SB; Galloway, AC; Grossi, EA
2002 Mar 6;39(5):120A-120A, Journal of the American College of Cardiology
— id: 27516, year: 2002, vol: 39, page: 120A, stat: Journal Article,

Cardiac vein angioplasty for biventricular pacing
Sandler, David A; Feigenblum, David Y; Bernstein, Neil E; Holmes, Douglas S; Chinitz, Larry A
2002 Dec;25(12):1788-1789, Pacing & clinical electrophysiology
— id: 96172, year: 2002, vol: 25, page: 1788, stat: Journal Article,

Is the Molecular Composition of K(ATP)Channels more Complex than Originally Thought?
Pountney DJ; Sun ZQ; Porter LM; Nitabach MN; Nakamura TY; Holmes D; Rosner E; Kaneko M; Manaris T; Holmes TC; Coetzee WA
2001 Aug;33(8):1541-1546, Journal of molecular & cellular cardiology
— id: 21130, year: 2001, vol: 33, page: 1541, stat: Journal Article,

T-Wave alternans during ventricular pacing
Fedor, MC; Chinitz, JS; Holmes, DS; Bernstein, NE; Ruffo, S; Manaris, A; Balch, LJ; Slater, W; Rey, M; Chinitz, LA
2000 FEB ;35(2):145A-145A, Journal of the American College of Cardiology
— id: 54748, year: 2000, vol: 35, page: 145A, stat: Journal Article,

Amiodarone inhibits cardiac ATP-sensitive potassium channels
Holmes DS; Sun ZQ; Porter LM; Bernstein NE; Chinitz LA; Artman M; Coetzee WA
2000 Oct;11(10):1152-1158, Journal of cardiovascular electrophysiology
— id: 39525, year: 2000, vol: 11, page: 1152, stat: Journal Article,