David Gutstein

Biosketch / Results /

David Gutstein, M.D.

Clinical Associate Professor;
Department of Medicine (Cardio Div)
NYU Cardiac Exercise / Stress Lab

Clinical Addresses

522 First Avenue
Smilow 804
New York, NY 10016
Phone: 212-263-5666

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Medical Specialties


Clinical Responsibilities

David E. Gutstein, M.D., is an attending in Nuclear Cardiology at the NYU Medical Center. A native of Chicago, he attended Northwestern University for both his undergraduate studies and medical school. He completed his internship and residency at Harvard's Beth Israel Hospital in Boston. He trained in clinical and nuclear cardiology at the Mount Sinai Medical Center in New York. He obtained his research training in molecular cardiology in a program sponsored by the National Institutes of Health. After spending several years on staff at the Mount Sinai Medical Center, he was recruited to the faculty of the NYU Medical Center in 2002. Dr. Gutstein is a nationally recognized and well-published molecular cardiology researcher with funding from the National Institutes of Health and the American Heart Association.



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Board Certification

2006 — Ab Internal Medicine - Internal Medicine
2009 — Ab Internal Medicine (Cardiovascular Disease)


1991 — Northwestern University Medical School, Medical Education
1991-1994 — Beth Israel Hospital (Medicine), Residency Training
1994-1995 — Hadassah University Hospital (Cardiology Research), Clinical Fellowships
1995-1999 — Mount Sinai Medical Center (Cardiology), Clinical Fellowships

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Research Summary

Intercellular communication in the heart is mediated by gap junctions, channels that are critical for normal heart morphogenesis and for cardiac conduction. Although gap junctions play a vital role in cardiac physiology and are known to be dysregulated in disease, no available therapeutics are presently targeted to them. To investigate pathways that regulate and are regulated by gap junctions, Dr. Gutstein studies two specific areas of gap junction biology. First, Dr. Gutstein uses developmental models to investigate the effect of gap junctions on cardiac development. Germline loss of connexin43 (Cx43), the predominant cardiac gap junction component protein, is known to cause right ventricular outflow tract malformations, perinatal death and coronary anomalies. Research in the Gutstein laboratory suggests that the Cx43-null coronary phenotype may result from loss of Cx43 specifically in the neural crest population. However, the mechanisms by which Cx43 regulates the contribution of the neural crest to coronary development are not known. Ongoing studies in the laboratory are directed at identifying and characterizing how gap junctions may influence coronary patterning. The second area of interest in Dr. Gutstein's laboratory is the study of gap junction remodeling (GJR). Structural GJR is an abnormal localization of connexin protein along the sarcolemma of the myocyte and/or a generalized down-regulation of gap junction protein. The process of GJR has been strongly associated with arrhythmic cardiac conditions such as myocardial hypertrophy, infarction and heart failure. Dr. Gutstein has developed a novel method to induce GJR in the mouse by pacing at rates just over that of sinus rhythm for six hours. This is the first such method for use in the mouse that does not cause myocardial injury, hypertrophy or a decrease in cardiac function. Studies in the laboratory use this model to study the mechanisms by which GJR develops and the physiologic effects of GJR in the heart.

Research Interests

Dr. Gutstein's research interests revolve around the role of intercellular communication in cardiac development and function. Gap junctions are specialized intercellular channels that allow the passage of ions and small molecules between cells. Connexin43 (Cx43), the most abundant gap junction protein in the heart, plays a critical role in heart development, cardiac function and conduction. Understanding developmental pathways and mechanisms in the embryonic heart may provide insight into the pathophysiology of heart failure, a process often associated with recapitulation of fetal gene expression patterns.

Research Keywords

cardiovascular development<br>gap junction<br>connexin

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All data from NYU Health Sciences Library Faculty Bibliography — -


Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors
Gonzalez-Nieto, Daniel; Li, Lina; Kohler, Anja; Ghiaur, Gabriel; Ishikawa, Eri; Sengupta, Amitava; Madhu, Malav; Arnett, Jorden L; Santho, Rebecca A; Dunn, Susan K; Fishman, Glenn I; Gutstein, David E; Civitelli, Roberto; Barrio, Luis C; Gunzer, Matthias; Cancelas, Jose A
2012 May;119(22):5144-5154, Blood
— id: 170679, year: 2012, vol: 119, page: 5144, stat: Journal Article,

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Taniguchi Ishikawa, Eri; Gonzalez-Nieto, Daniel; Ghiaur, Gabriel; Dunn, Susan K; Ficker, Ashley M; Murali, Bhuvana; Madhu, Malav; Gutstein, David E; Fishman, Glenn I; Barrio, Luis C; Cancelas, Jose A
2012 Jun;109(23):9071-9076, Proceedings of the National Academy of Sciences of the United States of America
— id: 169558, year: 2012, vol: 109, page: 9071, stat: Journal Article,

Connexin-43 Expression Regulates the Migration of Hematopoietic Stem Cells and Progenitors towards and From Bone Marrow
Gonzalez-Nieto, D; Chang, KH; Koehler, A; Arnett, J; Dunn, S; Li, L; Ghiaur, G; Sengupta, A; Fishman, G; Gutstein, D; Civitelli, R; Barrio, L; Gunzer, M; Cancelas, J
2009 NOV 20 ;114(22):234-234, Blood
— id: 109972, year: 2009, vol: 114, page: 234, stat: Journal Article,

Connexin-43 Regulates the Cell Cycle Entry of Hematopoietic Stem Cells within the Stem Cell Niche
Gonzalez-Nieto, D; Ghiaur, G; Li, L; Arnett, J; Dunn, S; Fishman, G; Gutstein, D; Civitelli, R; Cancelas, J
2009 NOV 20 ;114(22):602-603, Blood
— id: 109978, year: 2009, vol: 114, page: 602, stat: Journal Article,

Identification of binding partners for the cytoplasmic loop of connexin43: a novel interaction with beta-tubulin
Kang, Eunice Y; Ponzio, Marc; Gupta, Pritha P; Liu, Fangyu; Butensky, Adam; Gutstein, David E
2009 ;15(5-6):397-406, Cell communication & adhesion
— id: 138363, year: 2009, vol: 15, page: 397, stat: Journal Article,

Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts
Danik, Stephan B; Rosner, Gregg; Lader, Joshua; Gutstein, David E; Fishman, Glenn I; Morley, Gregory E
2008 Apr;22(4):1204-1212, FASEB journal
— id: 75197, year: 2008, vol: 22, page: 1204, stat: Journal Article,

A novel proteomic interaction involving the cytoplasmic loop of connexin43 and tubulin
Gupta, PP; Kang, E; Ponzio, M; Butensky, A; Gutstein, DE
2008 MAR 11 ;51(10):A376-A376, Journal of the American College of Cardiology
— id: 78391, year: 2008, vol: 51, page: A376, stat: Journal Article,

Dyssynchronous activation in heterozygous Cx43 germline knockout mice induces steady-state potassium current remodelling and sustained dyssynchrony
Kontogeorgis, A; Kaba, RA; Li, X; Wit, AL; Morley, GE; Peters, NS; Gutstein, DE
2008 JUL ;94(3):A1-A1, Heart (British Cardiac Society)
— id: 86971, year: 2008, vol: 94, page: A1, stat: Journal Article,

Short-term pacing in the mouse alters cardiac expression of connexin43
Kontogeorgis, Andrianos; Kaba, Riyaz A; Kang, Eunice; Feig, Jonathan E; Gupta, Pritha P; Ponzio, Marc; Liu, Fangyu; Rindler, Michael J; Wit, Andrew L; Fisher, Edward A; Peters, Nicholas S; Gutstein, David E
2008 ;8:8-8, BMC physiology
— id: 79562, year: 2008, vol: 8, page: 8, stat: Journal Article,

Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents
Kontogeorgis, Andrianos; Li, Xiaodong; Kang, Eunice Y; Feig, Jonathan E; Ponzio, Marc; Kang, Guoxin; Kaba, Riyaz A; Wit, Andrew L; Fisher, Edward A; Morley, Gregory E; Peters, Nicholas S; Coetzee, William A; Gutstein, David E
2008 Nov;295(5):H1905-H1916, American journal of physiology. Heart & circulatory physiology
— id: 116200, year: 2008, vol: 295, page: H1905, stat: Journal Article,

Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival
Laws, Mary J; Taylor, Robert N; Sidell, Neil; DeMayo, Francesco J; Lydon, John P; Gutstein, David E; Bagchi, Milan K; Bagchi, Indrani C
2008 Aug;135(15):2659-2668, Development
— id: 96574, year: 2008, vol: 135, page: 2659, stat: Journal Article,

Connexin40 imparts conduction heterogeneity to atrial tissue
Leaf, David E; Feig, Jonathan E; Vasquez, Carolina; Riva, Pamela L; Yu, Cindy; Lader, Joshua M; Kontogeorgis, Andrianos; Baron, Elvera L; Peters, Nicholas S; Fisher, Edward A; Gutstein, David E; Morley, Gregory E
2008 Oct 24;103(9):1001-1008, Circulation research
— id: 93330, year: 2008, vol: 103, page: 1001, stat: Journal Article,

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f)
Roepke, Torsten K; Kontogeorgis, Andrianos; Ovanez, Christopher; Xu, Xianghua; Young, Jeffrey B; Purtell, Kerry; Goldstein, Peter A; Christini, David J; Peters, Nicholas S; Akar, Fadi G; Gutstein, David E; Lerner, Daniel J; Abbott, Geoffrey W
2008 Oct;22(10):3648-3660, FASEB journal
— id: 96573, year: 2008, vol: 22, page: 3648, stat: Journal Article,

Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion
Malester, Brian; Tong, Xiaoyong; Ghiu, Ioana; Kontogeorgis, Andrianos; Gutstein, David E; Xu, Jie; Hendricks-Munoz, Karen D; Coetzee, William A
2007 Jul;21(9):2162-2172, FASEB journal
— id: 73407, year: 2007, vol: 21, page: 2162, stat: Journal Article,

Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice
Sridharan, Santhi; Simon, Liz; Meling, Daryl D; Cyr, Daniel G; Gutstein, David E; Fishman, Glenn I; Guillou, Florian; Cooke, Paul S
2007 May;76(5):804-812, Biology of reproduction
— id: 96066, year: 2007, vol: 76, page: 804, stat: Journal Article,

Long form of latent TGF-{beta} binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
Todorovic, Vesna; Frendewey, David; Gutstein, David E; Chen, Yan; Freyer, Laina; Finnegan, Erin; Liu, Fangyu; Murphy, Andrew; Valenzuela, David; Yancopoulos, George; Rifkin, Daniel B
2007 Oct;134(20):3723-3732, Development
— id: 74213, year: 2007, vol: 134, page: 3723, stat: Journal Article,

Contrast-enhanced MRI of right ventricular abnormalities in Cx43 mutant mouse embryos
Wadghiri, Youssef Zaim; Schneider, Amanda E; Gray, Emily N; Aristizabal, Orlando; Berrios, Cesar; Turnbull, Daniel H; Gutstein, David E
2007 May;20(3):366-374, NMR in biomedicine
— id: 72869, year: 2007, vol: 20, page: 366, stat: Journal Article,

Dyskinesis in Chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of mice
Durand, Jorge L; Tang, Baiyu; Gutstein, David E; Petkova, Stefka; Teixeira, Mauro M; Tanowitz, Herbert B; Jelicks, Linda A
2006 Oct;24(8):1051-1057, Magnetic resonance imaging
— id: 96575, year: 2006, vol: 24, page: 1051, stat: Journal Article,

Short-term ventricular pacing induces gap junctional remodelling in the murine heart
Kaba, R; Kontogeorgis, A; Sereysky, J; Lewitton, S; Wit, A; Peters, N; Gutstein, D
2006 MAY ;92(21):A99-A99, Heart (British Cardiac Society)
— id: 64400, year: 2006, vol: 92, page: A99, stat: Journal Article,

Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
Liu, Shasha; Liu, Fangyu; Schneider, Amanda E; St Amand, Tara; Epstein, Jonathan A; Gutstein, David E
2006 May;133(10):2063-2073, Development
— id: 64787, year: 2006, vol: 133, page: 2063, stat: Journal Article,

Cardiac outflow tract defects in mice lacking LTBP-1L
Todorovic, V; Freyer, L; Gutstein, D; Frendewey, D; Rifkin, D
2006 NOV ;25(2):S26-S26, Matrix biology
— id: 70620, year: 2006, vol: 25, page: S26, stat: Journal Article,

Consequences of Cardiac Myocyte-Specific Ablation of KATP channels in Transgenic Mice expressing Dominant Negative Kir6 Subunits
Tong, XiaoYong; Porter, Lisa M; Liu, GongXin; Dhar-Chowdhury, Piyali; Srivastava, Shekhar; Pountney, David J; Yoshida, Hidetada; Artman, Michael; Fishman, Glenn I; Yu, Cindy; Iyer, Ramesh; Morley, Gregory E; Gutstein, David E; Coetzee, William A
2006 Aug;291(2):H543-H551, American journal of physiology. Heart & circulatory physiology
— id: 63616, year: 2006, vol: 291, page: H543, stat: Journal Article,

MR imaging of caveolin gene-specific alterations in right ventricular wall thickness
De Souza, Andrea Pereira; Cohen, Alex W; Park, David S; Woodman, Scott E; Tang, Baiyu; Gutstein, David E; Factor, Stephen M; Tanowitz, Herbert B; Lisanti, Michael P; Jelicks, Linda A
2005 Jan;23(1):61-68, Magnetic resonance imaging
— id: 60891, year: 2005, vol: 23, page: 61, stat: Journal Article,

Focal Gap Junction Uncoupling and Spontaneous Ventricular Ectopy
Gutstein, David E; Danik, Stephan B; Lewitton, Steve; France, David; Liu, Fangyu; Chen, Franklin L; Zhang, Jie; Ghodsi, Newsha; Morley, Gregory E; Fishman, Glenn I
2005 Sep;289(3):H1091-H1098, American journal of physiology. Heart & circulatory physiology
— id: 56033, year: 2005, vol: 289, page: H1091, stat: Journal Article,

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy
Lee, AW; Presley, CA; Kastl, BD; Igbinosa, II; Yamada, Y; Fishman, GI; Gutstein, DE; Cancelas, JA
2005 NOV 16 ;106(11):141A-141A, Blood
— id: 61461, year: 2005, vol: 106, page: 141A, stat: Journal Article,

Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation
Morley, Gregory E; Danik, Stephan B; Bernstein, Scott; Sun, Yanjie; Rosner, Gregg; Gutstein, David E; Fishman, Glenn I
2005 Mar 15;102(11):4126-4129, Proceedings of the National Academy of Sciences of the United States of America
— id: 52629, year: 2005, vol: 102, page: 4126, stat: Journal Article,

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy
Presley, Cynthia A; Lee, Andrew W; Kastl, Bryan; Igbinosa, Irogue; Yamada, Yoshiyuki; Fishman, Glenn I; Gutstein, David E; Cancelas, Jose A
2005 Jul-Dec;12(5-6):307-317, Cell communication & adhesion
— id: 63617, year: 2005, vol: 12, page: 307, stat: Journal Article,

Modulation of cardiac gap junction expression and arrhythmic susceptibility
Danik, Stephan B; Liu, Fangyu; Zhang, Jie; Suk, H Jacqueline; Morley, Gregory E; Fishman, Glenn I; Gutstein, David E
2004 Nov 12;95(10):1035-1041, Circulation research
— id: 48218, year: 2004, vol: 95, page: 1035, stat: Journal Article,

Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia induction
Gutstein, David E; Danik, Stephan B; Sereysky, Jedd B; Morley, Gregory E; Fishman, Glenn I
2003 Sep;285(3):H1091-H1096, American journal of physiology. Heart & circulatory physiology
— id: 39225, year: 2003, vol: 285, page: H1091, stat: Journal Article,

The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions
Gutstein, David E; Liu, Fang-Yu; Meyers, Marian B; Choo, Andrew; Fishman, Glenn I
2003 Mar 1;116(Pt 5):875-885, Journal of cell science
— id: 39315, year: 2003, vol: 116, page: 875, stat: Journal Article,

Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts
Yao, Jian-An; Gutstein, David E; Liu, Fangyu; Fishman, Glenn I; Wit, Andrew L
2003 Nov 17;93(8):736-743, Circulation research
— id: 45733, year: 2003, vol: 93, page: 736, stat: Journal Article,

Progressive loss of connexin43 in the heart yields a phenotypic shift from ventricular dysfunction to fatal arrhythmias
Gutstein, DE; Liu, FY; Zhang, J; Chen, FL; Ghodsi, N; Kini, AS; Fishman, GI
2002 NOV 5 ;106(19):152-153, Circulation
— id: 37201, year: 2002, vol: 106, page: 152, stat: Journal Article,

The cardiac gap junction: a potential therapeutic target in the treatment of heart disease
Liu, Fangyu; Gutstein, David E
2002 Nov;69(6):421-424, Mount Sinai journal of medicine
— id: 60892, year: 2002, vol: 69, page: 421, stat: Journal Article,

Exercise training normalizes altered calcium-handling proteins during development of heart failure
Lu, Lu; Mei, Dan Feng; Gu, An-Guo; Wang, Su; Lentzner, Benjamin; Gutstein, David E; Zwas, Donna; Homma, Shunichi; Yi, Geng-Hua; Wang, Jie
2002 Apr;92(4):1524-1530, Journal of applied physiology (Bethesda)
— id: 27762, year: 2002, vol: 92, page: 1524, stat: Journal Article,

Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart
Gutstein DE; Morley GE; Fishman GI
2001 ;8(4-6):345-348, Cell adhesion & communications
— id: 32705, year: 2001, vol: 8, page: 345, stat: Journal Article,

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
Gutstein DE; Morley GE; Tamaddon H; Vaidya D; Schneider MD; Chen J; Chien KR; Stuhlmann H; Fishman GI
2001 Feb 16;88(3):333-339, Circulation research
— id: 27670, year: 2001, vol: 88, page: 333, stat: Journal Article,

Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction
Gutstein DE; Morley GE; Vaidya D; Liu F; Chen FL; Stuhlmann H; Fishman GI
2001 Sep 4;104(10):1194-1199, Circulation
— id: 27669, year: 2001, vol: 104, page: 1194, stat: Journal Article,

Predicting plaque rupture: enhancing diagnosis and clinical decision-making in coronary artery disease
Fischer A; Gutstein DE; Fayad ZA; Fuster V
2000 ;5(3):163-172, Vascular medicine
— id: 27763, year: 2000, vol: 5, page: 163, stat: Journal Article,

Thrombosis and coagulation abnormalities in the acute coronary syndromes
Fischer A; Gutstein DE; Fuster V
1999 May;17(2):'213'-'214', Cardiology clinics
— id: 27764, year: 1999, vol: 17, page: '213', stat: Journal Article,

Pathophysiology and clinical significance of atherosclerotic plaque rupture
Gutstein DE; Fuster V
1999 Feb;41(2):323-333, Cardiovascular research
— id: 27765, year: 1999, vol: 41, page: 323, stat: Journal Article,

Intracellular calcium release channel expression during embryogenesis
Rosemblit N; Moschella MC; Ondriasa E; Gutstein DE; Ondrias K; Marks AR
1999 Feb 15;206(2):163-177, Developmental biology (Orlando)
— id: 27766, year: 1999, vol: 206, page: 163, stat: Journal Article,

Pathophysiologic bases for adjunctive therapies in the treatment and secondary prevention of acute myocardial infarction
Gutstein DE; Fuster V
1998 Mar;21(3):161-168, Clinical cardiology
— id: 27767, year: 1998, vol: 21, page: 161, stat: Journal Article,

Management of stable coronary artery disease
Gutstein DE; Fuster V
1997 Jul;56(1):'339'-'341', American family physician
— id: 27770, year: 1997, vol: 56, page: '339', stat: Journal Article,

Role of inositol 1,4,5-trisphosphate receptors in regulating apoptotic signaling and heart failure
Gutstein DE; Marks AR
1997 ;Suppl 12(3):53-57, Heart vessels
— id: 27768, year: 1997, vol: Suppl 12, page: 53, stat: Journal Article,

Nontraumatic intramural hematoma of the duodenum complicating warfarin therapy
Gutstein DE; Rosenberg SJ
1997 Sep-Oct;64(4-5):339-341, Mount Sinai journal of medicine
— id: 27769, year: 1997, vol: 64, page: 339, stat: Journal Article,

Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium
Gutstein DE; Flemmal K; Bruce E; Travers KE; Gwathmey JK; Ransil BJ; Markis JE; Grossman W; Morgan JP
1996 Dec;2(4):285-292, Journal of cardiac failure
— id: 27771, year: 1996, vol: 2, page: 285, stat: Journal Article,

Abnormal myocardial calcium handling in the early stage of adriamycin cardiomyopathy
Kapelko VI; Williams CP; Gutstein DE; Morgan JP
1996 ;104(2):185-191, Archives of physiology & biochemistry
— id: 27772, year: 1996, vol: 104, page: 185, stat: Journal Article,