Gilbert J Grant

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Gilbert J Grant, M.D.

Associate Professor; Vice Chair Academic Affairs; Director of Obstetric Anesthesiology
Department of Anesthesiology (Anesthesiology)
NYU Anesthesia Associates

Clinical Addresses

DEPARTMENT OF ANESTHESIOLOGY
550 FIRST AVENUE
NEW YORK, NY 10016
Phone: 212-263-5072

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Medical Specialties

Anesthesiology

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA POS, AETNA PPO/EPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, FIDELIS CHLD HLTH, FIDELIS EXCHANGE, FIDELIS FAM HLTH, FIDELIS MEDICARE, Fidelis Medicaid, GHI CBP, HEALTHREPUBLIC, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP FAM HLTH, HIP HMO, HIP MEDICAID, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, MULTIPLAN/PHCS PPO, OSCAR, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, Tricare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS

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Board Certification

1986 — Ab Anesthesiology - Anesthesiology

Education

1978-1982 — University of Michigan Medical School, Medical Education
1982-1983 — Columbia Presbyterian Medical Center (Obstetrics & Gynecology), Internship
1983-1986 — NYU Medical Center (Anesthesiology), Residency Training
1985-1986 — New York University School of Medicine (Cardiac Anesthesia), Clinical Fellowships

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Research Summary

Pain after surgery and trauma is often inadequately treated, resulting in unecessary suffering and possibly leading to significant medical complications. A simple, effective, and reliable means of providing analgesia would be greatly beneficial. To this end, our laboratory has focused on using liposomes, currently used as a biocompatable means of drug delivery for various pharmaceuticals, as slow-release, drug-delivery vehicles. By acting as a slow-release vehicle for analgesics, liposomes potentially can provide prolonged analgesia in patients suffering from pain with a single drug administration. Our laboratory is involved in developing liposomal delivery systems for local anesthetics and narcotics. To date, we have demonstrated that liposomal encapsulation produces a five to ten times prolongation of analgesia when compared to free drug in animal models. We plan to assess the safety of these formulations so that they can then undergo efficacy testing in humans. We view these promising results as offering hope that liposomal narcotic and local anesthetic formulations may be used clinically to significantly decrease pain and suffering in patients.

Research Interests

Prolonged Analgesia Using Liposomal Delivery Systems

Research Keywords

analgesia, liposomes, local anesthetics, narcotics, pain

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Prolonged analgesia from Bupisome and Bupigel formulations: From design and fabrication to improved stability
Cohen, Rivka; Kanaan, Hiba; Grant, Gilbert J; Barenholz, Yechezkel
2012 Jun;160(2):346-352, Journal of controlled release
— id: 169587, year: 2012, vol: 160, page: 346, stat: Journal Article,

Safely giving regional anesthesia to gravidas with clotting disorders
Grant GJ
2007 ;52(8):40-2,45,49 Aug, Contemporary ob/gyn
— id: 74275, year: 2007, vol: 52, page: 40, stat: Journal Article,

Patient-controlled epidural analgesia and transformational change
Grant, Gilbert J; Grant, Abraham H
2006 Apr;15(2):170; author reply 170-170; author reply 170, International journal of obstetric anesthesia
— id: 96493, year: 2006, vol: 15, page: 170; author reply 170, stat: Journal Article,

Simpson, Semmelweis, and transformational change - In reply
Grant, GJ; Grant, AH; Lockwood, CJ
2005 NOV ;106(5):1108-1108, Obstetrics & gynecology
— id: 58900, year: 2005, vol: 106, page: 1108, stat: Journal Article,

Obstetric anesthesia: update 2004
Grant GJ; Halpern S
2004 ;49(7):44-6,48,49passim Jul, Contemporary ob/gyn
— id: 57892, year: 2004, vol: 49, page: 44, stat: Journal Article,

Intrathecal administration of liposomal neostigmine prolongs analgesia in mice
Grant, G J; Piskoun, B; Bansinath, M
2002 Jan;46(1):90-94, Acta anaesthesiologica Scandinavica
— id: 39696, year: 2002, vol: 46, page: 90, stat: Journal Article,

Liposomal delivery systems for local anesthetics
Grant GJ; Bansinath M
2001 Jan-Feb;26(1):61-63, Regional anesthesia & pain medicine
— id: 26803, year: 2001, vol: 26, page: 61, stat: Journal Article,

DRV liposomal bupivacaine: preparation, characterization, and in vivo evaluation in mice
Grant GJ; Barenholz Y; Piskoun B; Bansinath M; Turndorf H; Bolotin EM
2001 Mar;18(3):336-343, Pharmacheutical research
— id: 21143, year: 2001, vol: 18, page: 336, stat: Journal Article,

Perineural antinociceptive effect of opioids in a rat model
Grant GJ; Vermeulen K; Zakowski MI; Langerman L
2001 Aug;45(7):906-910, Acta anaesthesiologica Scandinavica
— id: 26699, year: 2001, vol: 45, page: 906, stat: Journal Article,

An in vivo method for the quantitative evaluation of local anesthetics
Grant GJ; Piskoun B; Lin A; Bansinath M
2000 Jan-Feb;43(1):69-72, Journal of pharmacological & toxicological methods
— id: 39513, year: 2000, vol: 43, page: 69, stat: Journal Article,

Wound infiltration with liposomal bupivacaine prolongs analgesia in rats
Grant GJ; Lax J; Susser L; Zakowski M; Weissman TE; Turndorf H
1997 Feb;41(2):204-207, Acta anaesthesiologica Scandinavica
— id: 7159, year: 1997, vol: 41, page: 204, stat: Journal Article,

Sufentanil transfer in the human placenta during in vitro perfusion
Krishna BR; Zakowski MI; Grant GJ
1997 Sep;44(9):996-1001, Canadian journal of anaesthesia
— id: 12285, year: 1997, vol: 44, page: 996, stat: Journal Article,

Effect of intrathecally administered local anesthetics on protein phosphorylation in the spinal cord
Nivarthi RN; Grant GJ; Turndorf H; Bansinath M
1997 Apr 4;53(7):979-986, Biochemical pharmacology
— id: 7227, year: 1997, vol: 53, page: 979, stat: Journal Article,

Hemodynamic effects of intrathecal fentanyl in nonlaboring term parturients
Grant GJ; Susser L; Cascio M; Moses M; Zakowski MI
1996 Mar;8(2):99-103, Journal of clinical anesthesia
— id: 6913, year: 1996, vol: 8, page: 99, stat: Journal Article,

Spinal anesthesia by local anesthetics stimulates the enzyme protein kinase C and induces the expression of an immediate early oncogene, c-Fos
Nivarthi RN; Grant GJ; Turndorf H; Bansinath M
1996 Sep;83(3):542-547, Anesthesia & analgesia
— id: 7027, year: 1996, vol: 83, page: 542, stat: Journal Article,

UPTAKE AND TRANSFER OF MORPHINE IN HUMAN PLACENTA DURING IN-VITRO PERFUSION
BUI, T; ZAKOWSKI, MI; GRANT, GJ; TURNDORF, H
1995 SEP ;83(3A):A932-A932, Anesthesiology
— id: 86721, year: 1995, vol: 83, page: A932, stat: Journal Article,

Intrathecal administration of liposomal morphine in a mouse model
Grant GJ; Cascio M; Zakowski MI; Langerman L; Turndorf H
1995 Sep;81(3):514-518, Anesthesia & analgesia
— id: 6830, year: 1995, vol: 81, page: 514, stat: Journal Article,

WOUND INFILTRATION WITH LIPOSOMAL BUPIVACAINE PRODUCES PROLONGED ANALGESIA IN RATS
GRANT, GJ; LAX, J; SUSSER, L; ZAKOWSKI, M; TURNDORF, H
1995 SEP ;83(3A):A813-A813, Anesthesiology
— id: 86719, year: 1995, vol: 83, page: A813, stat: Journal Article,

Hot plate versus tail flick: evaluation of acute tolerance to continuous morphine infusion in the rat model
Langerman L; Zakowski MI; Piskoun B; Grant GJ
1995 Sep;34(1):23-27, Journal of pharmacological & toxicological methods
— id: 12740, year: 1995, vol: 34, page: 23, stat: Journal Article,

SPINAL-ANESTHESIA INCREASES PROTEIN-KINASE-C ACTIVITY IN THE SPINAL-CORD
RAJU, NN; GRANT, GJ; TURNDORF, H; BANSINATH, M
1995 SEP ;83(3A):A670-A670, Anesthesiology
— id: 86718, year: 1995, vol: 83, page: A670, stat: Journal Article,

PHARMACOKINETICS AND EFFECTS OF INTRATHECAL FENTANYL FOR LABOR ANALGESIA
ZAKOWSKI, M; MINN, M; HOSKINS, I; GRANT, GJ
1995 SEP ;83(3A):A942-A942, Anesthesiology
— id: 86722, year: 1995, vol: 83, page: A942, stat: Journal Article,

Prolonged analgesia with liposomal bupivacaine in a mouse model
Grant GJ; Vermeulen K; Langerman L; Zakowski M; Turndorf H
1994 Jul-Aug;19(4):264-269, Regional anesthesia
— id: 8245, year: 1994, vol: 19, page: 264, stat: Journal Article,

Prolonged analgesia and decreased toxicity with liposomal morphine in a mouse model
Grant GJ; Vermeulen K; Zakowski MI; Stenner M; Turndorf H; Langerman L
1994 Oct;79(4):706-709, Anesthesia & analgesia
— id: 6636, year: 1994, vol: 79, page: 706, stat: Journal Article,

The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model
Langerman L; Bansinath M; Grant GJ
1994 Sep;79(3):490-494, Anesthesia & analgesia
— id: 12900, year: 1994, vol: 79, page: 490, stat: Journal Article,

Duration of spinal anaesthesia is determined by the partition coefficient of local anaesthetic
Langerman L; Golomb E; Grant GJ; Benita S
1994 Apr;72(4):456-459, British journal of anaesthesia
— id: 6437, year: 1994, vol: 72, page: 456, stat: Journal Article,

Transfer and uptake of alfentanil in the human placenta during in vitro perfusion
Zakowski MI; Ham AA; Grant GJ
1994 Dec;79(6):1089-1093, Anesthesia & analgesia
— id: 6787, year: 1994, vol: 79, page: 1089, stat: Journal Article,

Pharmacokinetic profile of morphine in parturients following intravenous or epidural administration
Zakowski MI; Ramanathan S; Sutin KM; Grant GJ; Turndorf H
1994 ;19(2):119-125, Regional anesthesia
— id: 32334, year: 1994, vol: 19, page: 119, stat: Journal Article,

Thoracic versus lumbar administration of epidural morphine for postoperative analgesia after thoracotomy
Grant GJ; Zakowski M; Ramanathan S; Boyd A; Turndorf H
1993 Nov-Dec;18(6):351-355, Regional anesthesia
— id: 6395, year: 1993, vol: 18, page: 351, stat: Journal Article,

Assessing local anesthetic effect using the mouse tail flick test
Grant GJ; Zakowski MI; Vermeulen K; Langerman L; Ramanathan S; Turndorf H
1993 Aug;29(4):223-226, Journal of pharmacological & toxicological methods
— id: 6396, year: 1993, vol: 29, page: 223, stat: Journal Article,

A rat sciatic nerve model for independent assessment of sensory and motor block induced by local anesthetics [see comments]
Grant GJ; Vermeulen K; Zakowski MI; Sutin KM; Ramanathan S; Langerman L; Weissman TE; Turndorf H
1992 Dec;75(6):889-894, Anesthesia & analgesia
— id: 6394, year: 1992, vol: 75, page: 889, stat: Journal Article,

Prolongation of epidural anesthesia using a lipid drug carrier with procaine, lidocaine, and tetracaine
Langerman L; Grant GJ; Zakowski M; Golomb E; Ramanathan S; Turndorf H
1992 Dec;75(6):900-905, Anesthesia & analgesia
— id: 13355, year: 1992, vol: 75, page: 900, stat: Journal Article,

Prolongation of spinal anesthesia. Differential action of a lipid drug carrier on tetracaine, lidocaine, and procaine
Langerman L; Grant GJ; Zakowski M; Ramanathan S; Turndorf H
1992 Sep;77(3):475-481, Anesthesiology
— id: 13445, year: 1992, vol: 77, page: 475, stat: Journal Article,

The maternal hemodynamic effects of bupivacaine-epinephrine mixture used for obstetrical anesthesia
Grant GJ; Ramanathan S; Turndorf H
1990 Oct;34(7):543-547, Acta anaesthesiologica Scandinavica
— id: 8446, year: 1990, vol: 34, page: 543, stat: Journal Article,

The effects of local anesthetics on maternal and neonatal platelet function
Grant GJ; Ramanathan S; Patel N; Turndorf H
1989 Jul;33(5):409-412, Acta anaesthesiologica Scandinavica
— id: 10570, year: 1989, vol: 33, page: 409, stat: Journal Article,

Maternal hemodynamic effects of epinephrine added to local anesthetics
Grant GJ; Ramanathan S; Turndorf H
1988 ;69:A705-A705, Anesthesiology
— id: 106299, year: 1988, vol: 69, page: A705, stat: Journal Article,

Vasopressor therapy for hypotension due to epidural anesthesia for cesarean section
Ramanathan S; Grant GJ
1988 Oct;32(7):559-565, Acta anaesthesiologica Scandinavica
— id: 10942, year: 1988, vol: 32, page: 559, stat: Journal Article,

Left atrial injection of protamine does not reliably prevent pulmonary hypertension
Kronenfeld MA; Garguilo R; Weinberg P; Grant G; Thomas SJ; Turndorf H
1987 Oct;67(4):578-580, Anesthesiology
— id: 11350, year: 1987, vol: 67, page: 578, stat: Journal Article,