Gilbert J Grant

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Gilbert Grant

Associate Professor, Department of Anesthesiology
Anesthesiology
NYU Anesthesia Associates

Contact Info

Address
560 First Avenue
New York, NY 10016

212/263-5548

Research Summary

Pain after surgery and trauma is often inadequately treated, resulting in unecessary suffering and possibly leading to significant medical complications. A simple, effective, and reliable means of providing analgesia would be greatly beneficial. To this end, our laboratory has focused on using liposomes, currently used as a biocompatable means of drug delivery for various pharmaceuticals, as slow-release, drug-delivery vehicles. By acting as a slow-release vehicle for analgesics, liposomes potentially can provide prolonged analgesia in patients suffering from pain with a single drug administration. Our laboratory is involved in developing liposomal delivery systems for local anesthetics and narcotics. To date, we have demonstrated that liposomal encapsulation produces a five to ten times prolongation of analgesia when compared to free drug in animal models. We plan to assess the safety of these formulations so that they can then undergo efficacy testing in humans. We view these promising results as offering hope that liposomal narcotic and local anesthetic formulations may be used clinically to significantly decrease pain and suffering in patients.

Research Interests

Prolonged Analgesia Using Liposomal Delivery Systems

Transnasal topical sphenopalatine ganglion block to treat tension headache in a pregnant patient
Grant, G J; Schechter, D; Redai, I; Lax, J
2014-08-28; 0959-289x,International journal of obstetric anesthesia - id: 1153432, year: 2014 Letter

Prolonged analgesia from Bupisome and Bupigel formulations: From design and fabrication to improved stability
Cohen, Rivka; Kanaan, Hiba; Grant, Gilbert J; Barenholz, Yechezkel
2012-06-25; 0168-3659,Journal of controlled release - id: 169587, year: 2012 Journal Article

Safely giving regional anesthesia to gravidas with clotting disorders
Grant GJ
2012-02-05; 0090-3159,Contemporary ob/gyn - id: 74275, year: 2007

Patient-controlled epidural analgesia and transformational change
Grant, Gilbert J; Grant, Abraham H
2012-02-05; 0959-289X,International journal of obstetric anesthesia - id: 96493, year: 2006 Comment; Historical Article; Letter

Simpson, Semmelweis, and transformational change - In reply
Grant, GJ; Grant, AH; Lockwood, CJ
2012-02-05; 0029-7844,Obstetrics & gynecology - id: 58900, year: 2005