Gilbert J Grant

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Gilbert Grant

Associate Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine
NYU Anesthesia Associates

Contact Info

560 First Avenue
New York, NY 10016



1983-1986 — NYU Medical Center (Anesthesiology), Residency Training

Research Summary

Pain after surgery and trauma is often inadequately treated, resulting in unecessary suffering and possibly leading to significant medical complications. A simple, effective, and reliable means of providing analgesia would be greatly beneficial. To this end, our laboratory has focused on using liposomes, currently used as a biocompatable means of drug delivery for various pharmaceuticals, as slow-release, drug-delivery vehicles. By acting as a slow-release vehicle for analgesics, liposomes potentially can provide prolonged analgesia in patients suffering from pain with a single drug administration. Our laboratory is involved in developing liposomal delivery systems for local anesthetics and narcotics. To date, we have demonstrated that liposomal encapsulation produces a five to ten times prolongation of analgesia when compared to free drug in animal models. We plan to assess the safety of these formulations so that they can then undergo efficacy testing in humans. We view these promising results as offering hope that liposomal narcotic and local anesthetic formulations may be used clinically to significantly decrease pain and suffering in patients.

Research Interests

Prolonged Analgesia Using Liposomal Delivery Systems

Marketing or strategy? Defining the best approach to expand the anesthesiology workforce in Israel
Lewis, Michael C; Grant, Gilbert J
2015-08-30; 2045-4015,Israel journal of health policy research - id: 1742132, year: 2015 Journal Article

Transnasal topical sphenopalatine ganglion block to treat tension headache in a pregnant patient
Grant, G J; Schechter, D; Redai, I; Lax, J
2014-08-28; 0959-289x,International journal of obstetric anesthesia - id: 1153432, year: 2014 Letter

Epidural Simulation to Train Residents Prior to Obstetric Anesthesia Rotation
Lax, Jerome; Szyld, Demian; Ng, Grace; Riles, Thomas; Grant, Gilbert
2015-06-11; 1559-713x,Simulation in healthcare - id: 1622002, year: 2013

Prolonged analgesia from Bupisome and Bupigel formulations: From design and fabrication to improved stability
Cohen, Rivka; Kanaan, Hiba; Grant, Gilbert J; Barenholz, Yechezkel
2012-06-25; 0168-3659,Journal of controlled release - id: 169587, year: 2012 Journal Article

Safely giving regional anesthesia to gravidas with clotting disorders
Grant GJ
2012-02-05; 0090-3159,Contemporary ob/gyn - id: 74275, year: 2007