David B Friedman, M.D.

APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
Kopp, Jeffrey B; Nelson, George W; Sampath, Karmini; Johnson, Randall C; Genovese, Giulio; An, Ping; Friedman, David; Briggs, William; Dart, Richard; Korbet, Stephen; Mokrzycki, Michele H; Kimmel, Paul L; Limou, Sophie; Ahuja, Tejinder S; Berns, Jeffrey S; Fryc, Justyna; Simon, Eric E; Smith, Michael C; Trachtman, Howard; Michel, Donna M; Schelling, Jeffrey R; Vlahov, David; Pollak, Martin; Winkler, Cheryl A
2011 Nov;22(11):2129-2137, Journal of the American Society of Nephrology
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 African American cases, 168 European American cases, and 939 control subjects. In a recessive model, APOL1 variants conferred seventeenfold higher odds (95% CI 11 to 26) for focal segmental glomerulosclerosis (FSGS) and twenty-nine-fold higher odds (95% CI 13 to 68) for HIV-associated nephropathy (HIVAN). FSGS associated with two APOL1 risk alleles associated with earlier age of onset (P = 0.01) and faster progression to ESRD (P < 0.01) but similar sensitivity to steroids compared with other subjects. Individuals with two APOL1 risk alleles have an estimated 4% lifetime risk for developing FSGS, and untreated HIV-infected individuals have a 50% risk for developing HIVAN. The effect of carrying two APOL1 risk alleles explains 18% of FSGS and 35% of HIVAN; alternatively, eliminating this effect would reduce FSGS and HIVAN by 67%. A survey of world populations indicated that the APOL1 kidney risk alleles are present only on African chromosomes. In summary, African Americans carrying two APOL1 risk alleles have a greatly increased risk for glomerular disease, and APOL1-associated FSGS occurs earlier and progresses to ESRD more rapidly. These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice
— id: 146042, year: 2011, vol: 22, page: 2129, stat: Journal Article,

Recognition and source memory for pictures in children and adults
Cycowicz, YM; Friedman, D; Snodgrass, JG; Duff, M
2001 FEB ;39(3):255-267, Neuropsychologia
The present experiment investigated the developmental aspects of source compared to item memory. College students and 7-8-year-old children viewed pictures drawn in I ed or green during a study phase, and were asked either to remember the pictures for a subsequent recognition test, or to remember both the pictures and their associated colors for a subsequent source memory test. In the test phase, new and old pictures were presented in black. In the recognition task, participants were asked to make binary old:new recognition judgments, while in the source task, they were asked to make trinary old-green/old-red/new source judgements. Performance on all tasks improved with increasing age, but the age difference for sourer was much larger than that for item memory. It has been suggested that the frontal lobes play a critical role in the retrieval of source information, and that this brain region relative to the medial temporal lobes continues to develop into late adolescence. Thus, it is possible that immaturity of the frontal lobes may be causally related to the children's lower performance on the sourer memory task. (C) 2001 Elsevier Science Ltd. All rights reserved
— id: 98291, year: 2001, vol: 39, page: 255, stat: Journal Article,

Brain event-related potentials (ERPs) in schizophrenia during a word recognition memory task
Kayser, J; Bruder, G E; Friedman, D; Tenke, C E; Amador, X F; Clark, S C; Malaspina, D; Gorman, J M
1999 Dec;34(3):249-265, International journal of psychophysiology
Impairments of recognition memory for words and attenuation of the ERP 'old-new' effect have been found in patients with left medial temporal lobe damage. If left temporal lobe dysfunction in schizophrenia involves medial structures (e.g. hippocampus), then schizophrenic patients might show similar abnormalities of verbal recognition memory. This study recorded ERPs from 30 electrode sites while subjects were engaged in a continuous word recognition memory task. Results are reported for 24 patients having a diagnosis of schizophrenia (n = 16) or schizoaffective disorder (n = 8) and 19 age-matched healthy controls. Both patients and controls showed the expected 'old-new' effect, with greater late positivity to correctly recognized old words at posterior sites, and there was also no significant difference between groups in P3 amplitude. However, accuracy of word recognition memory was poorer in patients than controls, and patients showed markedly smaller N2 amplitude. Reduced amplitudes of N2 and N2-P3 were associated with poorer performance, with highest correlations over the left inferior parietal (N2) and left medial parietal (N2-P3) region. Moreover, patients failed to show significantly greater left than right hemisphere amplitude of N2-P3 at posterior sites, which was seen for healthy controls. These findings suggest that impaired word recognition in schizophrenia may arise from a left lateralized deficit at an early stage of processing, beginning at 200-300 ms after word onset
— id: 69151, year: 1999, vol: 34, page: 249, stat: Journal Article,

Episodic priming and memory for temporal source: Event-related potentials reveal age-related differences in prefrontal functioning
Trott, CT; Friedman, D; Ritter, W; Fabiani, M; Snodgrass, JG
1999 SEP ;14(3):390-413, Psychology & aging
Event-related potentials (ERPs) were recorded from young (M = 25) and older (M = 71) adults during a recognition memory paradigm that assessed episodic priming. Participants studied two temporally distinct lists of sentences (each with two unassociated nouns). At test, in response to the nouns, participants made old-new, followed by remember (context)-know (familiarity) and source (i.e., list) judgments. Both young and older adults showed equivalent episodic priming effects. However, compared to the young adults, the elder adults showed a greater source performance decrement than item memory performance decrement. Both age groups showed equivalent posterior-maximal old-new ERP effects. However, only the young produced a frontal-maximal, late onset old-new effect that differed as a function of subsequent list attribution. Because source memory is thought to be mediated by prefrontal cortex, we conclude that age-related memory differences may be due to a deficit in a prefrontal cortical system that underlies source memory and are not likely to be due to an age-related decline in episodic priming
— id: 98317, year: 1999, vol: 14, page: 390, stat: Journal Article,

A matter of fried onions
Friedman DB
1992 Dec;1(4):307-310, Seizure
In the 1946 film 'A Matter of Life and Death', complex partial seizures were portrayed in detail and with surprising accuracy. This study was conducted to determine the nature of the medical collaboration in the preparation of the film as well as the reasons why the creative team of Michael Powell and Emeric Pressburger included these details, but elected to make them invisible to all but those with medical educations
— id: 62547, year: 1992, vol: 1, page: 307, stat: Journal Article,

Parenting: a developmental process
Friedman AS; Friedman DB
1977 Sep;6(9):564-572, Pediatric annals
— id: 62549, year: 1977, vol: 6, page: 564, stat: Journal Article,

Discipline and alternatives to punishment
Friedman DB; Swinger HK
1977 Oct;6(10):636-636, Pediatric annals
— id: 62548, year: 1977, vol: 6, page: 636, stat: Journal Article,

Effectiveness and efficiency of indigenous health aides in a pediatric outpatient department
Wingert WA; Grubbs J; Lenoski EF; Friedman DB
1975 Aug;65(8):849-857, American journal of public health. AJPH
— id: 62550, year: 1975, vol: 65, page: 849, stat: Journal Article,

Community health aides: how effective are they?
Cauffman JG; Wingert WA; Friedman DB; Warburton EA; Hanes B
1970 Oct;60(10):1904-1909, American journal of public health & the nation's health
— id: 62551, year: 1970, vol: 60, page: 1904, stat: Journal Article,

Family interviewing and pediatric training. Teaching how to recognize and deal with family situations in which emotional problems aggravate chronic illness
Russak S; Friedman DB
1970 Oct;9(10):594-598, Clinical pediatrics
— id: 62552, year: 1970, vol: 9, page: 594, stat: Journal Article,

"Why Johnny's parents don't read." An analysis of indigent parents' comprehension of health education materials
Wingert WA; Grubbs JP; Friedman DB
1969 Nov;8(11):655-660, Clinical pediatrics
— id: 62553, year: 1969, vol: 8, page: 655, stat: Journal Article,

Immunization for children. Motivating families to complete a series
Wingert WA; Larsen W; Lenoski EF; Friedman DB
1969 Mar;110(3):207-212, California medicine
— id: 62555, year: 1969, vol: 110, page: 207, stat: Journal Article,

Indigenous health aides as counselors to parents about nutrition
Wingert WA; Larson W; Friedman DB
1969 Apr;84(4):328-332, Public Health Reports (1896-1970)
— id: 62554, year: 1969, vol: 84, page: 328, stat: Journal Article,

Pediatric emergency room patient. A comparison of patients seen during the day and at night
Wingert WA; Friedman DB; Larson WR
1968 Jan;115(1):48-56, American journal of diseases of children
— id: 62558, year: 1968, vol: 115, page: 48, stat: Journal Article,

The demographical and ecological characteristics of a large urban pediatric outpatient population and implications for improving community pedatric care
Wingert WA; Friedman DB; Larson WR
1968 May;58(5):859-876, American journal of public health & the nation's health
— id: 62557, year: 1968, vol: 58, page: 859, stat: Journal Article,

The influence of family organization on the utilization of pediatric emergency services
Wingert WA; Larson W; Friedman DB
1968 Nov;42(5):743-751, Pediatrics
— id: 62556, year: 1968, vol: 42, page: 743, stat: Journal Article,

Brief intervention as a preventive force in disorders of early childhood
Augenbraun B; Reid HL; Friedman DB
1967 Jul;37(4):697-702, American journal of orthopsychiatry
— id: 62559, year: 1967, vol: 37, page: 697, stat: Journal Article,

Obsessive hypermnesia and free association as a transference resistance
Friedman DB
1967 Jan;21(1):105-111, American journal of psychotherapy
— id: 62560, year: 1967, vol: 21, page: 105, stat: Journal Article,

Toward a unitary theory on the passing of the oedipal conflict
Friedman DB
1966 Spring;53(1):38-48, Psychoanalytic review
— id: 62561, year: 1966, vol: 53, page: 38, stat: Journal Article,

Clinical notes on the management of asthma and eczema. When to call the psychiatrist
Friedman DB; Selesnick ST
1965 Dec;4(12):735-738, Clinical pediatrics
— id: 62562, year: 1965, vol: 4, page: 735, stat: Journal Article,

PSYCHOLOGICAL MANAGEMENT OF CHILDHOOD ASTHMA
SELESNICK ST; FRIEDMAN DB; AUGENBRAUN B
1964 Jun;100:406-411, California medicine
— id: 62563, year: 1964, vol: 100, page: 406, stat: Journal Article,

The analyst's role
Robertiello, Richard C; Friedman, David B; Pollens, Bertram
New York : Citadel Press, 1963,
— id: 673, year: 1963, vol: , page: , stat: ,

On the phrase, 'beautiful but dumb'
FRIEDMAN DB
1962 ;49:100-102, Psychoanalysis & the Psychoanalytic Review
— id: 62564, year: 1962, vol: 49, page: 100, stat: Journal Article,

Death anxiety and the primal scene
FRIEDMAN DB
1961 1962 Winter;48:108-118, Psychoanalysis & the Psychoanalytic Review
— id: 62565, year: 1961, vol: 48, page: 108, stat: Journal Article,

Parent development
FRIEDMAN DB
1957 Jan;86(1):25-28, California medicine
— id: 62566, year: 1957, vol: 86, page: 25, stat: Journal Article,