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Sally FrenkelAssociate Professor, Department of Orthopaedic Surgery;Associate Professor, Department of Cell Biology
Asst Course Director for Anatomy Course, Inst Anatomy Histology & VC
550 First Avenue
New York, NY 10016
Research SummaryThe aging process and traumatic injuries frequently cause damage to articular cartilage that, if left untreated, can result in arthritic lesions of the joint surface with concomitant loss of function. With current treatment modalities, the resultant repair, typically consisting of fibrocartilage, often degenerates over time to arthritis. The aim of our research is to utilize tissue engineering techniques to develop a method for healing articular cartilage lesions. We successfully treated rabbit cartilage lesions with an implant consisting of rabbit chondrocytes in a collagen matrix carrier. We harvest and grow the rabbit cells in culture and seed them into a collagen bilayer, designed to prevent ingrowth of fibrous tissues into the lesion while acting as a scaffold for transplanted chondrocytes. The engineered collagen/chondrocyte construct is then implanted in articular defects in the rabbit knee.
Extensive mechanical, histological, and biochemical evaluations show that the regenerated cartilage has properties nearly identical to those of the normal cartilage. Furthermore, this neocartilage showed no sign of arthritic deterioration 6 mo after implantation. We continue to investigate the use of growth factors to enhance the repair induced by cell transplants, as well as cell-free devices. We have extended our studies to large animal models (dogs, goats) to replicate the clinical situation. Our most recent studies are testing the use of stem cells and gene therapy techniques to regenerate damaged articular surfaces.
Research InterestsChondrocyte Transplantation for Articular Cartilage Repair
The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
Zhao, Yun-Peng; Tian, Qing-Yun; Frenkel, Sally; Liu, Chuan-Ju. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials. 2013 Jun 5;34(27):6412-6421 (394052)
Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis
Mediero, Aranzazu; Frenkel, Sally R; Wilder, Tuere; He, Wenjie; Mazumder, Amitabha; Cronstein, Bruce N. Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis. Science translational medicine. 2012 May 23;4(135):135ra65-135ra65 135ra65 (167513)
The BioDigital Human: A Web-based 3D Platform for Medical Visualization and Education
Qualter, John; Sculli, Frank; Oliker, Aaron; Napier, Zachary; Lee, Sabrina; Garcia, Julio; Frenkel, Sally; Harnik, Victoria; Triola, Marc. The BioDigital Human: A Web-based 3D Platform for Medical Visualization and Education. Studies in health technology & informatics. 2012 ;173:359-361 (157490)
Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
Feng, Jian Q; Guo, Feng-Jin; Jiang, Bai-Chun; Zhang, Yan; Frenkel, Sally; Wang, Da-Wei; Tang, Wei; Xie, Yixia; Liu, Chuan-Ju. Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis. FASEB journal. 2010 Feb 2;24(6):1879-1892 (156179)
Adenosine A2A receptor agonists: Can they prevent/treat joint prosthesis loosening?
Mediero A.; Frenkel S.R.; Wilder T.; Immerman I.; Hadley S.; Howell R.D.; Hawly M.. Adenosine A2A receptor agonists: Can they prevent/treat joint prosthesis loosening? [Meeting Abstract]. Arthritis & rheumatism. 2010 ;62:1470-1470 (130923)