Sally R. Frenkel

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Sally R. Frenkel, Ph.D.

Associate Professor; Inst Anatomy Histology & VC; Asst Course Director for Anatomy Course
Departments of Cell Biology (Cell Biology) and Orthopaedic Surgery (Orthopaedic Surgery)

Contact Info

Address

Floor 6 Room 671
Medical Science Building
NY, NY 10016

212-263-0284
212-263-0284
Sally.Frenkel@nyumc.org

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Research Summary

The aging process and traumatic injuries frequently cause damage to articular cartilage that, if left untreated, can result in arthritic lesions of the joint surface with concomitant loss of function. With current treatment modalities, the resultant repair, typically consisting of fibrocartilage, often degenerates over time to arthritis. The aim of our research is to utilize tissue engineering techniques to develop a method for healing articular cartilage lesions. We successfully treated rabbit cartilage lesions with an implant consisting of rabbit chondrocytes in a collagen matrix carrier. We harvest and grow the rabbit cells in culture and seed them into a collagen bilayer, designed to prevent ingrowth of fibrous tissues into the lesion while acting as a scaffold for transplanted chondrocytes. The engineered collagen/chondrocyte construct is then implanted in articular defects in the rabbit knee.

Extensive mechanical, histological, and biochemical evaluations show that the regenerated cartilage has properties nearly identical to those of the normal cartilage. Furthermore, this neocartilage showed no sign of arthritic deterioration 6 mo after implantation. We continue to investigate the use of growth factors to enhance the repair induced by cell transplants, as well as cell-free devices. We have extended our studies to large animal models (dogs, goats) to replicate the clinical situation. Our most recent studies are testing the use of stem cells and gene therapy techniques to regenerate damaged articular surfaces.

Research Interests

Chondrocyte Transplantation for Articular Cartilage Repair

Research Keywords

cartilage repair, chondrocyte transplantation, tissue engineering

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All data from NYU Health Sciences Library Faculty Bibliography — -

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http://hsl.med.nyu.edu/faculty-bibliography-search

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
Zhao, Yun-Peng; Tian, Qing-Yun; Frenkel, Sally; Liu, Chuan-Ju
2013 Sep;34(27):6412-6421, Biomaterials
— id: 394052, year: 2013, vol: 34, page: 6412, stat: Journal Article,

Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis
Mediero, Aranzazu; Frenkel, Sally R; Wilder, Tuere; He, Wenjie; Mazumder, Amitabha; Cronstein, Bruce N
2012 May;4(135):135ra65-135ra65 135ra65, Science translational medicine
— id: 167513, year: 2012, vol: 4, page: 135ra65, stat: Journal Article,

The BioDigital Human: A Web-based 3D Platform for Medical Visualization and Education
Qualter, John; Sculli, Frank; Oliker, Aaron; Napier, Zachary; Lee, Sabrina; Garcia, Julio; Frenkel, Sally; Harnik, Victoria; Triola, Marc
2012 ;173:359-361, Studies in health technology & informatics
— id: 157490, year: 2012, vol: 173, page: 359, stat: Journal Article,

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
Feng, Jian Q; Guo, Feng-Jin; Jiang, Bai-Chun; Zhang, Yan; Frenkel, Sally; Wang, Da-Wei; Tang, Wei; Xie, Yixia; Liu, Chuan-Ju
2010 Jun;24(6):1879-1892, FASEB journal
— id: 156179, year: 2010, vol: 24, page: 1879, stat: Journal Article,

Adenosine A2A receptor agonists: Can they prevent/treat joint prosthesis loosening?
Mediero A.; Frenkel S.R.; Wilder T.; Immerman I.; Hadley S.; Howell R.D.; Hawly M.
2010 ;62:1470-1470, Arthritis & rheumatism
— id: 130923, year: 2010, vol: 62, page: 1470, stat: Journal Article,

Adenosine A2A receptor agonists: can they prevent/treat joint prosthesis loosening?
Munoz, Aranzazu Mediero; Frenkel, Sally R.; Immerman, Igor; Hadley, Scott; Howell, Damani; Cronstein, Bruce N.
2010 JUN ;6(6000):159-160, Purinergic signalling
— id: 113753, year: 2010, vol: 6, page: 159, stat: Journal Article,

The efficacy of intra-articular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions
Strauss, Eric; Schachter, Aaron; Frenkel, Sally; Rosen, Jeffrey
2009 Apr;37(4):720-726, American journal of sports medicine
— id: 100949, year: 2009, vol: 37, page: 720, stat: Journal Article,

p204 Protein Overcomes the Inhibition of Core Binding Factor {alpha}-1-mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins
Luan, Yi; Yu, Xiu-Ping; Yang, Ning; Frenkel, Sally; Chen, Lin; Liu, Chuan-Ju
2008 May;19(5):2113-2126, Molecular biology of the cell
— id: 78379, year: 2008, vol: 19, page: 2113, stat: Journal Article,

Estrogen's role in osteoarthritis: chondoprotective or condodestructive?
Frenkel SR; Liu C; Patel V; Leslie M; Sankin A; Siu S; DiCesare PE
2007 ;1:38-40, Probe: the publication of research on biomedical endeavors
— id: 75329, year: 2007, vol: 1, page: 38, stat: Journal Article,

Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix
Di Cesare, Paul E; Frenkel, Sally R; Carlson, Cathy S; Fang, Carrie; Liu, Chuanju
2006 May;24(5):1118-1127, Journal of orthopaedic research
— id: 159234, year: 2006, vol: 24, page: 1118, stat: Journal Article,

The repair response to osteochondral implant types in a rabbit model
Frenkel, Sally R; Kubiak, Erik N; Truncale, Kate G
2006 ;7(1):29-37, Cell & tissue banking
— id: 69334, year: 2006, vol: 7, page: 29, stat: Journal Article,

Regeneration of articular cartilage--evaluation of osteochondral defect repair in the rabbit using multiphasic implants
Frenkel, S R; Bradica, G; Brekke, J H; Goldman, S M; Ieska, K; Issack, P; Bong, M R; Tian, H; Gokhale, J; Coutts, R D; Kronengold, R T
2005 Sep;13(9):798-807, Osteoarthritis & cartilage
— id: 61417, year: 2005, vol: 13, page: 798, stat: Journal Article,

Scaffolds for articular cartilage repair
Frenkel, Sally R; Di Cesare, Paul E
2004 Feb;32(1):26-34, Annals of biomedical engineering
— id: 46211, year: 2004, vol: 32, page: 26, stat: Journal Article,

Bone response to a novel highly porous surface in a canine implantable chamber
Frenkel, Sally R; Jaffe, William L; Dimaano, Fred; Iesaka, Kazuho; Hua, Tian
2004 Nov 15;71B(2):387-391, Journal of biomedical materials research. Part B, Applied biomaterials
— id: 51386, year: 2004, vol: 71B, page: 387, stat: Journal Article,

Estrogen and osteoarthritis
Gokhale, Jayashree A; Frenkel, Sally R; Dicesare, Paul E
2004 Mar;33(2):71-80, American journal of orthopedics (Belle Mead, NJ)
— id: 46195, year: 2004, vol: 33, page: 71, stat: Journal Article,

Clinical applications of growth factors for articular cartilage repair
Hickey, Derrick G; Frenkel, Sally R; Di Cesare, Paul E
2003 Feb;32(2):70-76, American journal of orthopedics (Belle Mead, NJ)
— id: 69335, year: 2003, vol: 32, page: 70, stat: Journal Article,

Efficacy of chondroprotective agents
Frenkel S; DiCesare PE
2002 ;13(1):9-13, Current opinion in orthopaedics
— id: 26865, year: 2002, vol: 13, page: 9, stat: Journal Article,

Osseointegration on metallic implant surfaces: effects of microgeometry and growth factor treatment
Frenkel, Sally R; Simon, Jordan; Alexander, Harold; Dennis, Michael; Ricci, John L
2002 ;63(6):706-713, Journal of biomedical materials research
— id: 156581, year: 2002, vol: 63, page: 706, stat: Journal Article,

The effect of alendronate (Fosamax) and implant surface on bone integration and remodeling in a canine model
Frenkel, S R; Jaffe, W L; Valle, C D; Jazrawi, L; Maurer, S; Baitner, A; Wright, K; Sala, D; Hawkins, M; Di Cesare, P E
2001 ;58(6):645-650, Journal of biomedical materials research
— id: 105470, year: 2001, vol: 58, page: 645, stat: Journal Article,

Transforming growth factor beta superfamily members: role in cartilage modeling
Frenkel SR; Saadeh PB; Mehrara BJ; Chin GS; Steinbrech DS; Brent B; Gittes GK; Longaker MT
2000 Mar;105(3):980-990, Plastic & reconstructive surgery
— id: 27858, year: 2000, vol: 105, page: 980, stat: Journal Article,

Repair of articular cartilage defects: part I. Basic Science of cartilage healing
Chen FS; Frenkel SR; Di Cesare PE
1999 Jan;28(1):31-33, American journal of orthopedics (Belle Mead, NJ)
— id: 6051, year: 1999, vol: 28, page: 31, stat: Journal Article,

Repair of articular cartilage defects: part II. Treatment options
Chen FS; Frenkel SR; Di Cesare PE
1999 Feb;28(2):88-96, American journal of orthopedics (Belle Mead, NJ)
— id: 6054, year: 1999, vol: 28, page: 88, stat: Journal Article,

Degradation and repair of articular cartilage
Frenkel SR; Di Cesare PE
1999 Oct 15;4:D671-D685, Frontiers in biosciences
— id: 56478, year: 1999, vol: 4, page: D671, stat: Journal Article,

Transforming growth factor beta superfamily members in cartilage repair
Frenkel S; Saadeh P; Mehrara B; Steinbrech D; Gittes G; Longaker MT
1998 ;49:516-518, Surgical forum
— id: 105479, year: 1998, vol: 49, page: 516, stat: Journal Article,

Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair - Reply
Frenkel, S
1998 JUL ;80B(4):743-744, Journal of bone & joint surgery (British volume)
— id: 53407, year: 1998, vol: 80B, page: 743, stat: Journal Article,

Development of a novel osteochondral graft for cartilage repair
Toolan, B C; Frenkel, S R; Pereira, D S; Alexander, H
1998 Aug;41(2):244-250, Journal of biomedical materials research
— id: 105478, year: 1998, vol: 41, page: 244, stat: Journal Article,

Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
Baragi VM; Renkiewicz RR; Qiu L; Brammer D; Riley JM; Sigler RE; Frenkel SR; Amin A; Abramson SB; Roessler BJ
1997 Jul;5(4):275-282, Osteoarthritis & cartilage
— id: 9731, year: 1997, vol: 5, page: 275, stat: Journal Article,

Chondrocyte transplantation and experimental treatment options for articular cartilage defects
Chen FS; Frenkel SR; Di Cesare PE
1997 Jun;26(6):396-406, American journal of orthopedics (Belle Mead, NJ)
— id: 7129, year: 1997, vol: 26, page: 396, stat: Journal Article,

Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex
Clancy RM; Rediske J; Tang X; Nijher N; Frenkel S; Philips M; Abramson SB
1997 Oct 1;100(7):1789-1796, Journal of clinical investigation
— id: 9733, year: 1997, vol: 100, page: 1789, stat: Journal Article,

Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair
Frenkel, S R; Toolan, B; Menche, D; Pitman, M I; Pachence, J M
1997 Sep;79(5):831-836, Journal of bone & joint surgery (British volume)
— id: 105471, year: 1997, vol: 79, page: 831, stat: Journal Article,

''Outside/in'' signalling in the chondrocyte: Effect of nitric oxide on fibronectin induced actin assembly and focal adhesion kinase-dependent tyrosine phosphorylation
Clancy, RM; Rediske, J; Tang, X; Frenkel, S; Abramson, SB
1996 MAR ;44(3):A241-A241, Journal of investigative medicine
— id: 52955, year: 1996, vol: 44, page: A241, stat: Journal Article,

alpha 5 beta 1 integrin signaling in the chondrocyte: Nitric oxide disrupts fibronectin induced assembly of a subplasmalemmal actin Rho A FAK activation complex
Clancy, RM; Rediske, J; Tang, XY; Frenkel, SR; Abramson, SB
1996 SEP ;39(9):843-843, Arthritis & rheumatism
— id: 52781, year: 1996, vol: 39, page: 843, stat: Journal Article,

Effects of nitric oxide on chondrocyte migration, adhesion, and cytoskeletal assembly
Frenkel SR; Clancy RM; Ricci JL; Di Cesare PE; Rediske JJ; Abramson SB
1996 Nov;39(11):1905-1912, Arthritis & rheumatism
— id: 9737, year: 1996, vol: 39, page: 1905, stat: Journal Article,

A comparison of abrasion burr arthroplasty and subchondral drilling in the treatment of full-thickness cartilage lesions in the rabbit
Menche, D S; Frenkel, S R; Blair, B; Watnik, N F; Toolan, B C; Yaghoubian, R S; Pitman, M I
1996 Jun;12(3):280-286, Arthroscopy
— id: 105473, year: 1996, vol: 12, page: 280, stat: Journal Article,

Dynamics of p55 soluble TNF alpha receptor (p55sTNF-R) release by human OA cartilage
Rediske, J; Koehne, C; Frenkel, S; Skiles, J
1996 SEP ;39(9):1454-1454, Arthritis & rheumatism
— id: 52787, year: 1996, vol: 39, page: 1454, stat: Journal Article,

Effects of growth-factor-enhanced culture on a chondrocyte-collagen implant for cartilage repair
Toolan, B C; Frenkel, S R; Pachence, J M; Yalowitz, L; Alexander, H
1996 Jun;31(2):273-280, Journal of biomedical materials research
— id: 105472, year: 1996, vol: 31, page: 273, stat: Journal Article,

NITRIC-OXIDE INHIBITS CHONDROCYTE ADHESION TO FIBRONECTIN VIA EFFECTS ON INTRACELLULAR ACTIN POLYMERIZATION
CLANCY, RM; FRENKEL, SR; DICESARE, P; ABRAMSON, S
1995 SEP ;38(9):429-429, Arthritis & rheumatism
— id: 86694, year: 1995, vol: 38, page: 429, stat: Journal Article,

Demineralized bone matrix. Enhancement of spinal fusion
Frenkel SR; Moskovich R; Spivak J; Zhang ZH; Prewett AB
1993 Sep 15;18(12):1634-1639, Spine
— id: 35852, year: 1993, vol: 18, page: 1634, stat: Journal Article,

Diffusion of fibroblast growth factor from a plaster of Paris carrier
Rosenblum, S F; Frenkel, S; Ricci, J R; Alexander, H
1993 Spring;4(1):67-72, Journal of applied biomaterials (Orlando)
— id: 105474, year: 1993, vol: 4, page: 67, stat: Journal Article,

Fibroblast growth factor: effects on osteogenesis and chondrogenesis in the chick embryo
Frenkel, S R; Herskovits, M S; Singh, I J
1992 ;145(3):265-268, Acta anatomica
— id: 105475, year: 1992, vol: 145, page: 265, stat: Journal Article,

Fibroblast growth factor in chick osteogenesis
Frenkel, S R; Grande, D A; Collins, M; Singh, I J
1990 Jul;11:38-40, Biomaterials
— id: 105476, year: 1990, vol: 11, page: 38, stat: Journal Article,

Nerve growth factor in skeletal tissues of the embryonic chick
Frenkel, S R; Guerra, L A; Mitchell, O G; Singh, I J
1990 May;260(3):507-511, Cell & tissue research
— id: 156166, year: 1990, vol: 260, page: 507, stat: Journal Article,