Glenn I Fishman

Biosketch / Results /

Glenn I Fishman, M.D.

Professor; William Goldring Professor of Medicine; Vice Chair Research Dept of Medicine; Dir Division of Cardiology
Departments of Medicine (Cardio Div), Neuroscience and Physiology (Neuro/Phys) and Biochemistry and Molecular Pharmacology
NYU Cardiology Associates
NYU EKG Associates

Clinical Addresses

The Leon H. Charney Division of Cardiology
522 First Avenue, Smilow 801
New York, NY 10016
Handicap Access: yes
Phone: 212-263-3967
Fax: 212-263-3972

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Medical Specialties

Cardiology

Medical Expertise

Arrhythmia

Director, Cardiovascular Research Program

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, CIGNA EPO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS PATHWAYS / PATHWAYS ENHANCED, EBCBS POS, EBCBS PPO, GHI CBP, HEALTHPLUS CHLD HLTH (AMERIGROUP), HEALTHPLUS FAM HLTH (AMERIGROUP), HEALTHPLUS MEDICAID (AMERIGROUP), HEALTHREPUBLIC, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP HMO, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, MULTIPLAN/PHCS PPO, Medicare, NYS EMPIRE PLAN, OSCAR, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS, UPN Elite

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

1986 — Ab Internal Medicine - Internal Medicine
1989 — Ab Internal Medicine (Cardiovascular Disease)

Education

1983 — Stanford University, Medical Education
1983-1984 — Massachusetts General Hospital (Medicine), Residency Training
1984-1986 — Massachusetts General Hospital (Medicine), Residency Training
1986-1988 — Columbia-Presbyterian Medical Ctr. (Cardiology), Clinical Fellowships
1988-1990 — Albert Einstein College Hospital (Molecular Cardiology), Clinical Fellowships

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Research Summary

My laboratory focuses on several facets of cardiovascular biology and disease. First, we are interested in the formation and function of the heart's specialized cardiac conduction system (CCS). This complex network comprises pacemaking cells that establish the normal rhythmicity of the heart, as well as rapidly conducting His-Purkinje cells that facilitate highly synchronized excitation of the working myocardium.

Our studies of the conduction system utilize genetically engineered mouse models that specifically visualize various components of the network. Gene profiling of microdissected CCS tissue is then employed to identify the molecular signature of these specialized cells. A complementary approach for gene discovery using murine embryonic stem cells is being developed, whereby such pluripotent cells can be differentiated into specific components of the CCS under defined cultured conditions.

A second area of investigation includes studies of arrhythmia mechanisms, focusing especially on the dysregulation of gap junction channels and the associated abnormalities in impulse propagation. These studies include a multiple of strategies that range from molecular and biochemical through genetically engineered murine models with site-specific mutations in connexin genes, which encode the gap junction channel proteins. Our laboratory was the first to demonstrate the essential role of gap junction channels in cardiac rhythmicity, using conditional knockout approaches. Current studies are focused on defining the role of post-translational regulation of connexins during normal gap junction formation and in response to pathologic stimuli that lead to abnormal gap junction remodeling.

Research Interests

Cardiovascular genetics; cardiovascular development; cardiac electrophysiology and arrhythmias

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias
Hartman, Matthew E; Liu, Yonggang; Zhu, Wei-Zhong; Chien, Wei-Ming; Weldy, Chad S; Fishman, Glenn I; Laflamme, Michael A; Chin, Michael T
2014 Jul;28(7):3007-3015, FASEB journal
— id: 1072322, year: 2014, vol: 28, page: 3007, stat: Journal Article,

Myogenic bladder defects in mouse models of human oculodentodigital dysplasia
Huang, Tao; Shao, Qing; Barr, Kevin; Simek, Jamie; Fishman, Glenn I; Laird, Dale W
2014 Feb;457(3):441-449, Biochemical journal
— id: 740852, year: 2014, vol: 457, page: 441, stat: Journal Article,

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression
Josowitz, Rebecca; Lu, Jia; Falce, Christine; D'Souza, Sunita L; Wu, Meng; Cohen, Ninette; Dubois, Nicole C; Zhao, Yong; Sobie, Eric A; Fishman, Glenn I; Gelb, Bruce D
2014 ;9(7):e101316-e101316 e101316, PLoS one
— id: 1074872, year: 2014, vol: 9, page: e101316, stat: Journal Article,

PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
Kim, Eugene E; Shekhar, Akshay; Lu, Jia; Lin, Xianming; Liu, Fang-Yu; Zhang, Jie; Delmar, Mario; Fishman, Glenn I
2014 Oct;:1378-1379, Journal of clinical investigation
— id: 1299982, year: 2014, vol: , page: 1378, stat: Journal Article,

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis, and arrhythmias in murine hearts
Lin, Xianming; O'Malley, Heather; Chen, Chunling; Auerbach, David; Foster, Monique; Shekhar, Akshay; Zhang, Mingliang; Coetzee, William; Jalife, Jose; Fishman, Glenn I; Isom, Lori; Delmar, Mario
2014 Aug;:?-? e103992, Journal of physiology
— id: 1142052, year: 2014, vol: , page: ?, stat: Journal Article,

Isolation and Characterization of ESC-Derived Cardiac Purkinje Cells
Maass, Karen; Shekhar, Akshay; Lu, Jia; Kang, Guoxin; See, Fiona; Kim, Eugene; Delgado, Camila; Shen, Steven; Cohen, Lisa; Fishman, Glenn I
2014 Dec;:128-129, Stem Cells
— id: 1411522, year: 2014, vol: , page: 128, stat: Journal Article,

Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias
Park, David S; Cerrone, Marina; Morley, Gregory; Vasquez, Carolina; Fowler, Steven; Liu, Nian; Bernstein, Scott A; Liu, Fang-Yu; Zhang, Jie; Rogers, Christopher S; Priori, Silvia G; Chinitz, Larry A; Fishman, Glenn I
2014 Dec;:S64-S65, J Clin Invest
— id: 1410832, year: 2014, vol: , page: S64, stat: Journal Article,

Nav-igating through a complex landscape: SCN10A and cardiac conduction
Park, David S; Fishman, Glenn I
2014 Apr;124(4):1460-1462, Journal of clinical investigation
— id: 884172, year: 2014, vol: 124, page: 1460, stat: Journal Article,

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
Danielson, Laura S; Park, David S; Rotllan, Noemi; Chamorro-Jorganes, Aranzazu; Guijarro, Maria V; Fernandez-Hernando, Carlos; Fishman, Glenn I; Phoon, Colin K L; Hernando, Eva
2013 Apr;27(4):1460-1467, FASEB journal
— id: 271182, year: 2013, vol: 27, page: 1460, stat: Journal Article,

PCP4 Is a Key Regulator of Cardiac Purkinje Cell Calcium Homeostasis and Suppresses Arrhythmogenic Calcium Waves
Kim, E E; Shekhar, A; Zhang, J; Liu, F; Fishman, G I
2013 Nov;10(11):1746-1746, Heart rhythm
— id: 626912, year: 2013, vol: 10, page: 1746, stat: Journal Article,

Designer gap junctions that prevent cardiac arrhythmias
Kim, Eugene; Fishman, Glenn I
2013 Feb;23(2):33-38, Trends in cardiovascular medicine
— id: 217852, year: 2013, vol: 23, page: 33, stat: Journal Article,

Development of a Mouse ESC Reporter Line to Isolate Purkinje-Like Cardiac Conduction System Cells
Maass, K; Lu, J; See, F; D'Souza, S; Fishman, G I
2013 Nov;10(11):1748-1748, Heart rhythm
— id: 626922, year: 2013, vol: 10, page: 1748, stat: Journal Article,

Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system
Park, David S; Tompkins, Rose O; Liu, Fangyu; Zhang, Jie; Phoon, Colin K L; Zavadil, Jiri; Fishman, Glenn I
2013 ;2(9):968-978, Biology open
— id: 586412, year: 2013, vol: 2, page: 968, stat: Journal Article,

The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice
Stewart, Michael K G; Gong, Xiang-Qun; Barr, Kevin J; Bai, Donglin; Fishman, Glenn I; Laird, Dale W
2013 Jan;449(2):401-413, Biochemical journal
— id: 215792, year: 2013, vol: 449, page: 401, stat: Journal Article,

GATA factors efficiently direct cardiac fate from embryonic stem cells
Turbendian, Harma K; Gordillo, Miriam; Tsai, Su-Yi; Lu, Jia; Kang, Guoxin; Liu, Ting-Chun; Tang, Alice; Liu, Susanna; Fishman, Glenn I; Evans, Todd
2013 Apr;140(8):1639-1644, Development
— id: 288032, year: 2013, vol: 140, page: 1639, stat: Journal Article,

Gazing through the crystal ball of science-cardiovascular disease in 2100
Fishman, G I; Levin, R I
2012 2012;9(2):86-89, US cardiology
— id: 287912, year: 2012, vol: 9, page: 86, stat: Journal Article,

Channeling diversity: Gap junction expression in the heart
Giovannone, Steven; Remo, Benjamin F; Fishman, Glenn I
2012 Jul;9(7):1159-1162, Heart rhythm
— id: 170413, year: 2012, vol: 9, page: 1159, stat: Journal Article,

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors
Gonzalez-Nieto, Daniel; Li, Lina; Kohler, Anja; Ghiaur, Gabriel; Ishikawa, Eri; Sengupta, Amitava; Madhu, Malav; Arnett, Jorden L; Santho, Rebecca A; Dunn, Susan K; Fishman, Glenn I; Gutstein, David E; Civitelli, Roberto; Barrio, Luis C; Gunzer, Matthias; Cancelas, Jose A
2012 May;119(22):5144-5154, Blood
— id: 170679, year: 2012, vol: 119, page: 5144, stat: Journal Article,

Characterization of gap junction proteins in the bladder of cx43 mutant mouse models of oculodentodigital dysplasia
Lorentz, R; Shao, Q; Huang, T; Fishman, G I; Laird, D W
2012 Jun;245(5-6):345-355, Journal of membrane biology
— id: 174567, year: 2012, vol: 245, page: 345, stat: Journal Article,

Forever young: induced pluripotent stem cells as models of inherited arrhythmias
Park, David S; Fishman, Glenn I
2012 Jun;125(25):3055-3056, Circulation
— id: 170424, year: 2012, vol: 125, page: 3055, stat: Journal Article,

Connexin43 cardiac gap junction remodeling: lessons from genetically engineered murine models
Remo, Benjamin F; Giovannone, Steven; Fishman, Glenn I
2012 Jun;245(5-6):275-281, Journal of membrane biology
— id: 174076, year: 2012, vol: 245, page: 275, stat: Journal Article,

Myocardial notch signaling reprograms cardiomyocytes to a conduction-like phenotype
Rentschler, Stacey; Yen, Alberta H; Lu, Jia; Petrenko, Nataliya B; Lu, Min Min; Manderfield, Lauren J; Patel, Vickas V; Fishman, Glenn I; Epstein, Jonathan A
2012 Aug;126(9):1058-1066, Circulation
— id: 178140, year: 2012, vol: 126, page: 1058, stat: Journal Article,

Development of a mESC reporter line to identify cardiac conduction system cells
See, F; Lu, J; Maass, K; D'Souza, S; Fishman, G I
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884412, year: 2012, vol: 23, page: , stat: Journal Article,

Mammary gland defects as revealed by genetically-modified mice harboring an oculodentodigital dysplasia-linked Cx43 mutant
Stewart, M K; Gong, X -Q; Barr, K J; Bai, D; Fishman, G I; Laird, D W
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884442, year: 2012, vol: 23, page: , stat: Journal Article,

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Taniguchi Ishikawa, Eri; Gonzalez-Nieto, Daniel; Ghiaur, Gabriel; Dunn, Susan K; Ficker, Ashley M; Murali, Bhuvana; Madhu, Malav; Gutstein, David E; Fishman, Glenn I; Barrio, Luis C; Cancelas, Jose A
2012 Jun;109(23):9071-9076, Proceedings of the National Academy of Sciences of the United States of America
— id: 169558, year: 2012, vol: 109, page: 9071, stat: Journal Article,

Full report from the first annual Heart Rhythm Society Research Forum: a vision for our research future, "dream, discover, develop, deliver"
Albert, Christine M; Chen, Peng-Sheng; Anderson, Mark E; Cain, Michael E; Fishman, Glenn I; Narayan, Sanjiv M; Olgin, Jeffrey E; Spooner, Peter M; Stevenson, William G; Van Wagoner, David R; Packer, Douglas L
2011 Dec;8(12):e1-12, Heart rhythm
— id: 347282, year: 2011, vol: 8, page: e1, stat: Journal Article,

Unique properties of the ATP-sensitive K + channel in the mouse ventricular cardiac conduction system
Bao, L; Kefaloyianni, E; Lader, J; Hong, M; Morley, G; Fishman, GI; Sobie, EA; Coetzee, WA
2011 ;4(6):926-935, Circulation. Arrhythmia & electrophysiology
— id: 784382, year: 2011, vol: 4, page: 926, stat: Journal Article,

Unique Properties of the ATP-Sensitive K+ Channel in the Mouse Ventricular Cardiac Conduction System
Bao, Li; Kefaloyianni, Eirini; Lader, Joshua; Hong, Miyoun; Morley, Gregory; Fishman, Glenn I; Sobie, Eric A; Coetzee, William A
2011 Dec 1;4(6):926-935, Circulation. Arrhythmia & electrophysiology
— id: 148727, year: 2011, vol: 4, page: 926, stat: Journal Article,

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load
Chin, King-Tung; Kang, Guoxin; Qu, Jiaxiang; Gardner, Lawrence B; Coetzee, William A; Zito, Ester; Fishman, Glenn I; Ron, David
2011 Aug;25(8):2583-2591, FASEB journal
— id: 135555, year: 2011, vol: 25, page: 2583, stat: Journal Article,

Remodeling of Atrial ATP-Sensitive Potassium Channels in a Model of Salt-induced Elevated Blood Pressure
Lader JM; Vasquez C; Bao L; Maass K; Qu J; Kefalogianni E; Fishman G; Coetzee WA; Morley GE
2011 Sep;301(3):H964-H974, American journal of physiology. Heart & circulatory physiology
— id: 135528, year: 2011, vol: 301, page: H964, stat: Journal Article,

The power of Pasteur's quadrant: cardiovascular disease at the turn of the century
Levin, Richard I; Fishman, Glenn I
2011 Jun;25(6):1788-1792, FASEB journal
— id: 134174, year: 2011, vol: 25, page: 1788, stat: Journal Article,

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes
Lin X; Liu N; Lu J; Zhang J; Anumonwo JM; Isom LL; Fishman GI; Delmar M
2011 Dec;8(12):1923-1930, Heart rhythm
— id: 137022, year: 2011, vol: 8, page: 1923, stat: Journal Article,

The role of connexin43 in the development of skeletal muscle using cell and animal models of oculodentodigital dysplasia
Merrifield, P A; Qing, S C; Vecchio, P; Fishman, G I; Laird, D W
2011 15 Dec 2011;22(24):-, Molecular biology of the cell
— id: 158623, year: 2011, vol: 22, page: , stat: Journal Article,

The cardiac conduction system
Park, David S; Fishman, Glenn I
2011 Mar 1;123(8):904-915, Circulation
— id: 129007, year: 2011, vol: 123, page: 904, stat: Journal Article,

Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias
Remo, Benjamin F; Qu, Jiaxiang; Volpicelli, Frank M; Giovannone, Steven; Shin, Daniel; Lader, Joshua; Liu, Fang-Yu; Zhang, Jie; Lent, Danielle S; Morley, Gregory E; Fishman, Glenn I
2011 Jun 10;108(12):1459-1466, Circulation research
— id: 134445, year: 2011, vol: 108, page: 1459, stat: Journal Article,

Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Fishman, Glenn I; Chugh, Sumeet S; Dimarco, John P; Albert, Christine M; Anderson, Mark E; Bonow, Robert O; Buxton, Alfred E; Chen, Peng-Sheng; Estes, Mark; Jouven, Xavier; Kwong, Raymond; Lathrop, David A; Mascette, Alice M; Nerbonne, Jeanne M; O'Rourke, Brian; Page, Richard L; Roden, Dan M; Rosenbaum, David S; Sotoodehnia, Nona; Trayanova, Natalia A; Zheng, Zhi-Jie
2010 Nov 30;122(22):2335-2348, Circulation
— id: 115431, year: 2010, vol: 122, page: 2335, stat: Journal Article,

Purkinje Cells From RyR2 Mutant Mice Are Highly Arrhythmogenic But Responsive to Targeted Therapy
Kang, Guoxin; Giovannone, Steven F; Liu, Nian; Liu, Fang-Yu; Zhang, Jie; Priori, Silvia G; Fishman, Glenn I
2010 Aug 20;107(4):512-519, Circulation research
— id: 111963, year: 2010, vol: 107, page: 512, stat: Journal Article,

Contactin-2 expression in the cardiac Purkinje fiber network
Pallante, Benedetta A; Giovannone, Steven; Fang-Yu, Liu; Zhang, Jie; Liu, Nian; Kang, Guoxin; Dun, Wen; Boyden, Penelope A; Fishman, Glenn I
2010 Apr 1;3(2):186-194, Circulation. Arrhythmia & electrophysiology
— id: 109201, year: 2010, vol: 3, page: 186, stat: Journal Article,

A colorful explanation for atrial arrhythmias
Remo, Benjamin F; Fishman, Glenn I
2010 Feb;23(1):3-4, Pigment cell & melanoma research
— id: 137024, year: 2010, vol: 23, page: 3, stat: Journal Article,

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Sotoodehnia, Nona; Isaacs, Aaron; de Bakker, Paul I W; Dorr, Marcus; Newton-Cheh, Christopher; Nolte, Ilja M; van der Harst, Pim; Muller, Martina; Eijgelsheim, Mark; Alonso, Alvaro; Hicks, Andrew A; Padmanabhan, Sandosh; Hayward, Caroline; Smith, Albert Vernon; Polasek, Ozren; Giovannone, Steven; Fu, Jingyuan; Magnani, Jared W; Marciante, Kristin D; Pfeufer, Arne; Gharib, Sina A; Teumer, Alexander; Li, Man; Bis, Joshua C; Rivadeneira, Fernando; Aspelund, Thor; Kottgen, Anna; Johnson, Toby; Rice, Kenneth; Sie, Mark P S; Wang, Ying A; Klopp, Norman; Fuchsberger, Christian; Wild, Sarah H; Mateo Leach, Irene; Estrada, Karol; Volker, Uwe; Wright, Alan F; Asselbergs, Folkert W; Qu, Jiaxiang; Chakravarti, Aravinda; Sinner, Moritz F; Kors, Jan A; Petersmann, Astrid; Harris, Tamara B; Soliman, Elsayed Z; Munroe, Patricia B; Psaty, Bruce M; Oostra, Ben A; Cupples, L Adrienne; Perz, Siegfried; de Boer, Rudolf A; Uitterlinden, Andre G; Volzke, Henry; Spector, Timothy D; Liu, Fang-Yu; Boerwinkle, Eric; Dominiczak, Anna F; Rotter, Jerome I; van Herpen, Ge; Levy, Daniel; Wichmann, H-Erich; van Gilst, Wiek H; Witteman, Jacqueline C M; Kroemer, Heyo K; Kao, W H Linda; Heckbert, Susan R; Meitinger, Thomas; Hofman, Albert; Campbell, Harry; Folsom, Aaron R; van Veldhuisen, Dirk J; Schwienbacher, Christine; O'Donnell, Christopher J; Volpato, Claudia Beu; Caulfield, Mark J; Connell, John M; Launer, Lenore; Lu, Xiaowen; Franke, Lude; Fehrmann, Rudolf S N; te Meerman, Gerard; Groen, Harry J M; Weersma, Rinse K; van den Berg, Leonard H; Wijmenga, Cisca; Ophoff, Roel A; Navis, Gerjan; Rudan, Igor; Snieder, Harold; Wilson, James F; Pramstaller, Peter P; Siscovick, David S; Wang, Thomas J; Gudnason, Vilmundur; van Duijn, Cornelia M; Felix, Stephan B; Fishman, Glenn I; Jamshidi, Yalda; Stricker, Bruno H Ch; Samani, Nilesh J; Kaab, Stefan; Arking, Dan E
2010 Dec;42(12):1068-1076, Nature genetics
— id: 137023, year: 2010, vol: 42, page: 1068, stat: Journal Article,

Connexin-43 Expression Regulates the Migration of Hematopoietic Stem Cells and Progenitors towards and From Bone Marrow
Gonzalez-Nieto, D; Chang, KH; Koehler, A; Arnett, J; Dunn, S; Li, L; Ghiaur, G; Sengupta, A; Fishman, G; Gutstein, D; Civitelli, R; Barrio, L; Gunzer, M; Cancelas, J
2009 NOV 20 ;114(22):234-234, Blood
— id: 109972, year: 2009, vol: 114, page: 234, stat: Journal Article,

Connexin-43 Regulates the Cell Cycle Entry of Hematopoietic Stem Cells within the Stem Cell Niche
Gonzalez-Nieto, D; Ghiaur, G; Li, L; Arnett, J; Dunn, S; Fishman, G; Gutstein, D; Civitelli, R; Cancelas, J
2009 NOV 20 ;114(22):602-603, Blood
— id: 109978, year: 2009, vol: 114, page: 602, stat: Journal Article,

Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart
Qu, Jiaxiang; Volpicelli, Frank M; Garcia, Luis I; Sandeep, Nefthi; Zhang, Jie; Marquez-Rosado, Lucrecia; Lampe, Paul D; Fishman, Glenn I
2009 Feb 13;104(3):365-371, Circulation research
— id: 96062, year: 2009, vol: 104, page: 365, stat: Journal Article,

Differential gene expression profiles between the murine cardiac conduction system and ventricular myocardium
See V.Y.; Wakimoto H.; Kim J.B.; Kwana M.; Moskowitz I.; Gorham J.; Wang L.; Fishman G.I.; Berul C.I.; Seidman J.G.; Seidman C.E.
2009 ;6(5 SUPPL 1):S101-S101, Heart rhythm
— id: 131852, year: 2009, vol: 6, page: S101, stat: Journal Article,

Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts
Danik, Stephan B; Rosner, Gregg; Lader, Joshua; Gutstein, David E; Fishman, Glenn I; Morley, Gregory E
2008 Apr;22(4):1204-1212, FASEB journal
— id: 75197, year: 2008, vol: 22, page: 1204, stat: Journal Article,

Ephaptic conduction in a cardiac strand model with 3D electrodiffusion
Mori, Yoichiro; Fishman, Glenn I; Peskin, Charles S
2008 Apr 29;105(17):6463-6468, Proceedings of the National Academy of Sciences of the United States of America
— id: 96063, year: 2008, vol: 105, page: 6463, stat: Journal Article,

Response to letters regarding article, "Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor"
Stroud, DM; Yu, C; Fishman, GI; Morley, GE; Gaussin, V; Burch, JBE; Mishina, Y; Schneider, MD
2008 AUG 5 ;118(6):E107-E107, Circulation
— id: 86825, year: 2008, vol: 118, page: E107, stat: Journal Article,

Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease
Wolf, Cordula M; Wang, Libin; Alcalai, Ronny; Pizard, Anne; Burgon, Patrick G; Ahmad, Ferhaan; Sherwood, Megan; Branco, Dorothy M; Wakimoto, Hiroko; Fishman, Glenn I; See, Vincent; Stewart, Colin L; Conner, David A; Berul, Charles I; Seidman, Christine E; Seidman, J G
2008 Feb;44(2):293-303, Journal of molecular & cellular cardiology
— id: 96064, year: 2008, vol: 44, page: 293, stat: Journal Article,

Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling
Collis, Leon P; Meyers, Marian B; Zhang, Jie; Phoon, Colin K L; Sobie, Eric A; Coetzee, William A; Fishman, Glenn I
2007 Feb;21(2):475-487, FASEB journal
— id: 72805, year: 2007, vol: 21, page: 475, stat: Journal Article,

Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia
Kalcheva, Nellie; Qu, Jiaxiang; Sandeep, Nefthi; Garcia, Luis; Zhang, Jie; Wang, Zhiyong; Lampe, Paul D; Suadicani, Sylvia O; Spray, David C; Fishman, Glenn I
2007 Dec 18;104(51):20512-20516, Proceedings of the National Academy of Sciences of the United States of America
— id: 75195, year: 2007, vol: 104, page: 20512, stat: Journal Article,

Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice
Sridharan, Santhi; Simon, Liz; Meling, Daryl D; Cyr, Daniel G; Gutstein, David E; Fishman, Glenn I; Guillou, Florian; Cooke, Paul S
2007 May;76(5):804-812, Biology of reproduction
— id: 96066, year: 2007, vol: 76, page: 804, stat: Journal Article,

Complex genomic rearrangement in CCS-LacZ transgenic mice
Stroud, Dina Myers; Darrow, Bruce J; Kim, Sang Do; Zhang, Jie; Jongbloed, Monique R M; Rentschler, Stacey; Moskowitz, Ivan P G; Seidman, Jonathan; Fishman, Glenn I
2007 Feb;45(2):76-82, Genesis
— id: 73836, year: 2007, vol: 45, page: 76, stat: Journal Article,

Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor
Stroud, Dina Myers; Gaussin, Vinciane; Burch, John B E; Yu, Cindy; Mishina, Yuji; Schneider, Michael D; Fishman, Glenn I; Morley, Gregory E
2007 Nov 27;116(22):2535-2543, Circulation
— id: 75196, year: 2007, vol: 116, page: 2535, stat: Journal Article,

Characterization of sinoatrial node in four conduction system marker mice
Viswanathan, S; Burch, J B E; Fishman, G I; Moskowitz, I P; Benson, D W
2007 May;42(5):946-953, Journal of molecular & cellular cardiology
— id: 347292, year: 2007, vol: 42, page: 946, stat: Journal Article,

Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions
del Corsso, Cristiane; Srinivas, Miduturu; Urban-Maldonado, Marcia; Moreno, Alonso P; Fort, Alfredo G; Fishman, Glenn I; Spray, David C
2006 ;1(4):1799-1809, Nature protocols
— id: 96065, year: 2006, vol: 1, page: 1799, stat: Journal Article,

Consequences of Cardiac Myocyte-Specific Ablation of KATP channels in Transgenic Mice expressing Dominant Negative Kir6 Subunits
Tong, XiaoYong; Porter, Lisa M; Liu, GongXin; Dhar-Chowdhury, Piyali; Srivastava, Shekhar; Pountney, David J; Yoshida, Hidetada; Artman, Michael; Fishman, Glenn I; Yu, Cindy; Iyer, Ramesh; Morley, Gregory E; Gutstein, David E; Coetzee, William A
2006 Aug;291(2):H543-H551, American journal of physiology. Heart & circulatory physiology
— id: 63616, year: 2006, vol: 291, page: H543, stat: Journal Article,

Isl1Cre reveals a common Bmp pathway in heart and limb development
Yang, Lei; Cai, Chen-Leng; Lin, Lizhu; Qyang, Yibing; Chung, Christine; Monteiro, Rui M; Mummery, Christine L; Fishman, Glenn I; Cogen, Anna; Evans, Sylvia
2006 Apr;133(8):1575-1585, Development
— id: 63615, year: 2006, vol: 133, page: 1575, stat: Journal Article,

Gap junction remodeling and ventricular arrhythmias
Fishman, Glenn I
2005 Aug;2(8):887-889, Heart rhythm
— id: 61250, year: 2005, vol: 2, page: 887, stat: Journal Article,

Understanding conduction system development: a hop, skip and jump away?
Fishman, Glenn I
2005 Apr 29;96(8):809-811, Circulation research
— id: 61380, year: 2005, vol: 96, page: 809, stat: Journal Article,

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus
Gaussin, Vinciane; Morley, Gregory E; Cox, Luk; Zwijsen, An; Vance, Kendra M; Emile, Lorin; Tian, Yimin; Liu, Jing; Hong, Chull; Myers, Dina; Conway, Simon J; Depre, Christophe; Mishina, Yuji; Behringer, Richard R; Hanks, Mark C; Schneider, Michael D; Huylebroeck, Danny; Fishman, Glenn I; Burch, John B E; Vatner, Stephen F
2005 Aug 5;97(3):219-226, Circulation research
— id: 61382, year: 2005, vol: 97, page: 219, stat: Journal Article,

Development of the right ventricular inflow tract and moderator band: a possible morphological and functional explanation for Mahaim tachycardia
Jongbloed, M R M; Wijffels, M C E F; Schalij, M J; Blom, N A; Poelmann, R E; van der Laarse, A; Mentink, M M T; Wang, Z; Fishman, G I; Gittenberger-de Groot, A C
2005 Apr;96(7):776-783, Circulation research
— id: 347302, year: 2005, vol: 96, page: 776, stat: Journal Article,

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy
Lee, AW; Presley, CA; Kastl, BD; Igbinosa, II; Yamada, Y; Fishman, GI; Gutstein, DE; Cancelas, JA
2005 NOV 16 ;106(11):141A-141A, Blood
— id: 61461, year: 2005, vol: 106, page: 141A, stat: Journal Article,

Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation
Morley, Gregory E; Danik, Stephan B; Bernstein, Scott; Sun, Yanjie; Rosner, Gregg; Gutstein, David E; Fishman, Glenn I
2005 Mar 15;102(11):4126-4129, Proceedings of the National Academy of Sciences of the United States of America
— id: 52629, year: 2005, vol: 102, page: 4126, stat: Journal Article,

Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
Ouvrard-Pascaud, Antoine; Sainte-Marie, Yannis; Benitah, Jean-Pierre; Perrier, Romain; Soukaseum, Christelle; Cat, Aurelie Nguyen Dinh; Royer, Anne; Le Quang, Khai; Charpentier, Flavien; Demolombe, Sophie; Mechta-Grigoriou, Fatima; Beggah, Ahmed T; Maison-Blanche, Pierre; Oblin, Marie-Edith; Delcayre, Claude; Fishman, Glenn I; Farman, Nicolette; Escoubet, Brigitte; Jaisser, Frederic
2005 Jun 14;111(23):3025-3033, Circulation
— id: 61379, year: 2005, vol: 111, page: 3025, stat: Journal Article,

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy
Presley, Cynthia A; Lee, Andrew W; Kastl, Bryan; Igbinosa, Irogue; Yamada, Yoshiyuki; Fishman, Glenn I; Gutstein, David E; Cancelas, Jose A
2005 Jul-Dec;12(5-6):307-317, Cell communication & adhesion
— id: 63617, year: 2005, vol: 12, page: 307, stat: Journal Article,

Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia
Wolf, Cordula M; Moskowitz, Ivan P G; Arno, Scott; Branco, Dorothy M; Semsarian, Christopher; Bernstein, Scott A; Peterson, Michael; Maida, Michael; Morley, Gregory E; Fishman, Glenn; Berul, Charles I; Seidman, Christine E; Seidman, J G
2005 Dec 13;102(50):18123-18128, Proceedings of the National Academy of Sciences of the United States of America
— id: 61378, year: 2005, vol: 102, page: 18123, stat: Journal Article,

Modulation of cardiac gap junction expression and arrhythmic susceptibility
Danik, Stephan B; Liu, Fangyu; Zhang, Jie; Suk, H Jacqueline; Morley, Gregory E; Fishman, Glenn I; Gutstein, David E
2004 Nov 12;95(10):1035-1041, Circulation research
— id: 48218, year: 2004, vol: 95, page: 1035, stat: Journal Article,

Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5
Czubryt, Michael P; McAnally, John; Fishman, Glenn I; Olson, Eric N
2003 Mar 18;100(4):1711-1716, Proceedings of the National Academy of Sciences of the United States of America
— id: 45735, year: 2003, vol: 100, page: 1711, stat: Journal Article,

Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia induction
Gutstein, David E; Danik, Stephan B; Sereysky, Jedd B; Morley, Gregory E; Fishman, Glenn I
2003 Sep;285(3):H1091-H1096, American journal of physiology. Heart & circulatory physiology
— id: 39225, year: 2003, vol: 285, page: H1091, stat: Journal Article,

The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions
Gutstein, David E; Liu, Fang-Yu; Meyers, Marian B; Choo, Andrew; Fishman, Glenn I
2003 Mar 1;116(Pt 5):875-885, Journal of cell science
— id: 39315, year: 2003, vol: 116, page: 875, stat: Journal Article,

Sorcin regulates excitation-contraction coupling in the heart
Meyers, Marian B; Fischer, Avi; Sun, Yan-Jie; Lopes, Coeli M B; Rohacs, Tibor; Nakamura, Tomoe Y; Zhou, Ying-Ying; Lee, Paul C; Altschuld, Ruth A; McCune, Sylvia A; Coetzee, William A; Fishman, Glenn I
2003 Aug 1;278(31):28865-28871, Journal of biological chemistry
— id: 39224, year: 2003, vol: 278, page: 28865, stat: Journal Article,

Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts
Yao, Jian-An; Gutstein, David E; Liu, Fangyu; Fishman, Glenn I; Wit, Andrew L
2003 Nov 17;93(8):736-743, Circulation research
— id: 45733, year: 2003, vol: 93, page: 736, stat: Journal Article,

Cellular and cis-regulation of En-2 expression in the mandibular arch
Degenhardt, Karl; Rentschler, Stacey; Fishman, Glenn; Sassoon, David A
2002 Feb;111(1-2):125-136, Mechanisms of development
— id: 61381, year: 2002, vol: 111, page: 125, stat: Journal Article,

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
Dor, Yuval; Djonov, Valentin; Abramovitch, Rinat; Itin, Ahuva; Fishman, Glenn I; Carmeliet, Peter; Goelman, Gadi; Keshet, Eli
2002 May 15;21(8):1939-1947, EMBO journal
— id: 45737, year: 2002, vol: 21, page: 1939, stat: Journal Article,

Progressive loss of connexin43 in the heart yields a phenotypic shift from ventricular dysfunction to fatal arrhythmias
Gutstein, DE; Liu, FY; Zhang, J; Chen, FL; Ghodsi, N; Kini, AS; Fishman, GI
2002 NOV 5 ;106(19):152-153, Circulation
— id: 37201, year: 2002, vol: 106, page: 152, stat: Journal Article,

Sorcin mediates calcium-dependent inactivation of cardiac L-type calcium channels
Meyers, MB; Sun, YJ; Lopes, C; Rohacs, T; Fishman, GI
2002 NOV 5 ;106(19):109-109, Circulation
— id: 37200, year: 2002, vol: 106, page: 109, stat: Journal Article,

Induction and patterning of the cardiac conduction system
Pennisi, David J; Rentschler, Stacey; Gourdie, Robert G; Fishman, Glenn I; Mikawa, Takashi
2002 Oct;46(6):765-775, International journal of developmental biology
— id: 45736, year: 2002, vol: 46, page: 765, stat: Journal Article,

Neuregulin-1 promotes formation of the murine cardiac conduction system
Rentschler, Stacey; Zander, Jennifer; Meyers, Kathleen; France, David; Levine, Rebecca; Porter, George; Rivkees, Scott A; Morley, Gregory E; Fishman, Glenn I
2002 Aug 6;99(16):10464-10469, Proceedings of the National Academy of Sciences of the United States of America
— id: 32704, year: 2002, vol: 99, page: 10464, stat: Journal Article,

A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects
Dor Y; Camenisch TD; Itin A; Fishman GI; McDonald JA; Carmeliet P; Keshet E
2001 Jun;128(9):1531-1538, Development
— id: 45738, year: 2001, vol: 128, page: 1531, stat: Journal Article,

Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart
Gutstein DE; Morley GE; Fishman GI
2001 ;8(4-6):345-348, Cell adhesion & communications
— id: 32705, year: 2001, vol: 8, page: 345, stat: Journal Article,

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
Gutstein DE; Morley GE; Tamaddon H; Vaidya D; Schneider MD; Chen J; Chien KR; Stuhlmann H; Fishman GI
2001 Feb 16;88(3):333-339, Circulation research
— id: 27670, year: 2001, vol: 88, page: 333, stat: Journal Article,

Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction
Gutstein DE; Morley GE; Vaidya D; Liu F; Chen FL; Stuhlmann H; Fishman GI
2001 Sep 4;104(10):1194-1199, Circulation
— id: 27669, year: 2001, vol: 104, page: 1194, stat: Journal Article,

Visualization and functional characterization of the developing murine cardiac conduction system
Rentschler S; Vaidya DM; Tamaddon H; Degenhardt K; Sassoon D; Morley GE; Jalife J; Fishman GI
2001 May;128(10):1785-1792, Development
— id: 32707, year: 2001, vol: 128, page: 1785, stat: Journal Article,

Wnt-1 regulation of connexin43 in cardiac myocytes
Ai Z; Fischer A; Spray DC; Brown AM; Fishman GI
2000 Feb;105(2):161-171, Journal of clinical investigation
— id: 45742, year: 2000, vol: 105, page: 161, stat: Journal Article,

Cyclic AMP regulates the HERG K(+) channel by dual pathways
Cui J; Melman Y; Palma E; Fishman GI; McDonald TV
2000 Jul 1;10(11):671-674, Current biology. CB
— id: 45740, year: 2000, vol: 10, page: 671, stat: Journal Article,

The dominant negative LQT2 mutation A561V reduces wild-type HERG expression
Kagan A; Yu Z; Fishman GI; McDonald TV
2000 May 14;275(15):11241-11248, Journal of biological chemistry
— id: 45739, year: 2000, vol: 275, page: 11241, stat: Journal Article,

Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
Redfern CH; Degtyarev MY; Kwa AT; Salomonis N; Cotte N; Nanevicz T; Fidelman N; Desai K; Vranizan K; Lee EK; Coward P; Shah N; Warrington JA; Fishman GI; Bernstein D; Baker AJ; Conklin BR
2000 May 25;97(9):4826-4831, Proceedings of the National Academy of Sciences of the United States of America
— id: 45741, year: 2000, vol: 97, page: 4826, stat: Journal Article,

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
Redfern CH; Coward P; Degtyarev MY; Lee EK; Kwa AT; Hennighausen L; Bujard H; Fishman GI; Conklin BR
1999 Mar;17(2):165-169, Nature biotechnology
— id: 45745, year: 1999, vol: 17, page: 165, stat: Journal Article,

Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart
Wickenden AD; Lee P; Sah R; Huang Q; Fishman GI; Backx PH
1999 Dec 26;85(11):1067-1076, Circulation research
— id: 45743, year: 1999, vol: 85, page: 1067, stat: Journal Article,

Timing is everything in life: conditional transgene expression in the cardiovascular system
Fishman GI
1998 Jun 4;82(8):837-844, Circulation research
— id: 45749, year: 1998, vol: 82, page: 837, stat: Journal Article,

Conditional lineage ablation to model human diseases
Lee P; Morley G; Huang Q; Fischer A; Seiler S; Horner JW; Factor S; Vaidya D; Jalife J; Fishman GI
1998 Oct 15;95(19):11371-11376, Proceedings of the National Academy of Sciences of the United States of America
— id: 45746, year: 1998, vol: 95, page: 11371, stat: Journal Article,

Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels
Meyers MB; Puri TS; Chien AJ; Gao T; Hsu PH; Hosey MM; Fishman GI
1998 Aug 24;273(30):18930-18935, Journal of biological chemistry
— id: 45747, year: 1998, vol: 273, page: 18930, stat: Journal Article,

The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure
Wickenden AD; Kaprielian R; Kassiri Z; Tsoporis JN; Tsushima R; Fishman GI; Backx PH
1998 Mar;37(2):312-323, Cardiovascular research
— id: 45748, year: 1998, vol: 37, page: 312, stat: Journal Article,

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM
1997 Dec 1;100(9):2189-2195, Journal of clinical investigation
— id: 45750, year: 1997, vol: 100, page: 2189, stat: Journal Article,

Modulation of cardiac ryanodine receptors by sorcin
Lokuta AJ; Meyers MB; Sander PR; Fishman GI; Valdivia HH
1997 Nov 3;272(40):25333-25338, Journal of biological chemistry
— id: 45751, year: 1997, vol: 272, page: 25333, stat: Journal Article,

A minK-HERG complex regulates the cardiac potassium current I(Kr)
McDonald TV; Yu Z; Ming Z; Palma E; Meyers MB; Wang KW; Goldstein SA; Fishman GI
1997 Aug 17;388(6639):289-292, Nature
— id: 45753, year: 1997, vol: 388, page: 289, stat: Journal Article,

Conditional transgene expression in the heart
Yu Z; Redfern CS; Fishman GI
1996 Nov;79(4):691-697, Circulation research
— id: 45754, year: 1996, vol: 79, page: 691, stat: Journal Article,

Conditional transgenics
Fishman, G I
1995 Nov-Dec;5(6):211-217, Trends in cardiovascular medicine
— id: 347312, year: 1995, vol: 5, page: 211, stat: Journal Article,

Association of sorcin with the cardiac ryanodine receptor
Meyers MB; Pickel VM; Sheu SS; Sharma VK; Scotto KW; Fishman GI
1995 Dec 3;270(44):26411-26418, Journal of biological chemistry
— id: 45757, year: 1995, vol: 270, page: 26411, stat: Journal Article,

Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice
De Leon JR; Federoff HJ; Dickson DW; Vikstrom KL; Fishman GI
1994 Feb 18;91(2):519-523, Proceedings of the National Academy of Sciences of the United States of America
— id: 45765, year: 1994, vol: 91, page: 519, stat: Journal Article,

Tetracycline-regulated cardiac gene expression in vivo
Fishman GI; Kaplan ML; Buttrick PM
1994 May;93(4):1864-1868, Journal of clinical investigation
— id: 45763, year: 1994, vol: 93, page: 1864, stat: Journal Article,

Regulated expression of foreign genes in vivo after germline transfer
Passman RS; Fishman GI
1994 ;94:2421-2425, Journal of clinical investigation
— id: 45760, year: 1994, vol: 94, page: 2421, stat: Journal Article,

Connexins and the heart
Fishman, G I
1992 Mar-Apr;2(2):50-55, Trends in cardiovascular medicine
— id: 347322, year: 1992, vol: 2, page: 50, stat: Journal Article,

The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures
Fishman GI; Eddy RL; Shows TB; Rosenthal L; Leinwand LA
1991 Jun;10(1):250-256, Genomics
— id: 45770, year: 1991, vol: 10, page: 250, stat: Journal Article,

Expression of connexin43 in the developing rat heart
Fishman GI; Hertzberg EL; Spray DC; Leinwand LA
1991 Apr;68(3):782-787, Circulation research
— id: 45771, year: 1991, vol: 68, page: 782, stat: Journal Article,

Functional analysis of human cardiac gap junction channel mutants
Fishman GI; Moreno AP; Spray DC; Leinwand LA
1991 Jun 1;88(9):3525-3529, Proceedings of the National Academy of Sciences of the United States of America
— id: 45769, year: 1991, vol: 88, page: 3525, stat: Journal Article,

Molecular characterization and functional expression of the human cardiac gap junction channel
Fishman GI; Spray DC; Leinwand LA
1990 Sep;111(2):589-598, Journal of cell biology
— id: 45772, year: 1990, vol: 111, page: 589, stat: Journal Article,