Biosketch / Results /
Glenn I Fishman, M.D.Professor; William Goldring Professor of Medicine; Vice Chair Research Dept of Medicine; Dir Division of Cardiology
Departments of Medicine (Cardio Div), Neuroscience and Physiology (Neuro/Phys) and Biochemistry and Molecular Pharmacology
NYU Cardiology Associates
NYU EKG Associates
Clinical AddressesTHE LEON H. CHARNEY DIVISION OF CARDIOLOGY
522 FIRST AVENUE, SMILOW 801
NEW YORK, NY 10016
Handicap Access: yes
Director, Cardiovascular Research Program
InsuranceAETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, Cigna HMO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, GHI CBP, HEALTHPLUS CHLD HLTH (AMERIGROUP), HEALTHPLUS FAM HLTH (AMERIGROUP), HEALTHPLUS MEDICAID (AMERIGROUP), HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP HMO, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, MULTIPLAN/PHCS PPO, Medicare, NYS EMPIRE PLAN, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS, UPN Elite
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Board Certification1986 — Ab Internal Medicine - Internal Medicine
1989 — Ab Internal Medicine (Cardiovascular Disease)
Education1983 — Stanford University, Medical Education
1983-1984 — Massachusetts General Hospital (Medicine), Residency Training
1984-1986 — Massachusetts General Hospital (Medicine), Residency Training
1986-1988 — Columbia-Presbyterian Medical Ctr. (Cardiology), Clinical Fellowships
1988-1990 — Albert Einstein College Hospital (Molecular Cardiology), Clinical Fellowships
My laboratory focuses on several facets of cardiovascular biology and disease. First, we are interested in the formation and function of the heart's specialized cardiac conduction system (CCS). This complex network comprises pacemaking cells that establish the normal rhythmicity of the heart, as well as rapidly conducting His-Purkinje cells that facilitate highly synchronized excitation of the working myocardium.
Our studies of the conduction system utilize genetically engineered mouse models that specifically visualize various components of the network. Gene profiling of microdissected CCS tissue is then employed to identify the molecular signature of these specialized cells. A complementary approach for gene discovery using murine embryonic stem cells is being developed, whereby such pluripotent cells can be differentiated into specific components of the CCS under defined cultured conditions.
A second area of investigation includes studies of arrhythmia mechanisms, focusing especially on the dysregulation of gap junction channels and the associated abnormalities in impulse propagation. These studies include a multiple of strategies that range from molecular and biochemical through genetically engineered murine models with site-specific mutations in connexin genes, which encode the gap junction channel proteins. Our laboratory was the first to demonstrate the essential role of gap junction channels in cardiac rhythmicity, using conditional knockout approaches. Current studies are focused on defining the role of post-translational regulation of connexins during normal gap junction formation and in response to pathologic stimuli that lead to abnormal gap junction remodeling.