Glenn I Fishman

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Glenn Fishman

William Goldring Professor of Medicine, Department of Medicine;Professor, Department of Biochemistry and Molecular Pharmacology;Professor, Department of Neuroscience and Physiology
Medicine
NYU Cardiology Associates
NYU EKG Associates

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-3967

Research Summary

My laboratory focuses on several facets of cardiovascular biology and disease. First, we are interested in the formation and function of the heart's specialized cardiac conduction system (CCS). This complex network comprises pacemaking cells that establish the normal rhythmicity of the heart, as well as rapidly conducting His-Purkinje cells that facilitate highly synchronized excitation of the working myocardium.

Our studies of the conduction system utilize genetically engineered mouse models that specifically visualize various components of the network. Gene profiling of microdissected CCS tissue is then employed to identify the molecular signature of these specialized cells. A complementary approach for gene discovery using murine embryonic stem cells is being developed, whereby such pluripotent cells can be differentiated into specific components of the CCS under defined cultured conditions.

A second area of investigation includes studies of arrhythmia mechanisms, focusing especially on the dysregulation of gap junction channels and the associated abnormalities in impulse propagation. These studies include a multiple of strategies that range from molecular and biochemical through genetically engineered murine models with site-specific mutations in connexin genes, which encode the gap junction channel proteins. Our laboratory was the first to demonstrate the essential role of gap junction channels in cardiac rhythmicity, using conditional knockout approaches. Current studies are focused on defining the role of post-translational regulation of connexins during normal gap junction formation and in response to pathologic stimuli that lead to abnormal gap junction remodeling.

Research Interests

Cardiovascular genetics; cardiovascular development; cardiac electrophysiology and arrhythmias

Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias
Park, D S; Cerrone, M; Morley, G; Vasquez, C; Fowler, S; Liu, N; Bernstein, S A; Liu, F -Y; Zhang, J; Rogers, C S; Priori, S G; Chinitz, L A; Fishman, G I
2015-02-04; 0021-9738,Journal of clinical investigation - id: 1450002, year: 2015

Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias
Hartman, Matthew E; Liu, Yonggang; Zhu, Wei-Zhong; Chien, Wei-Ming; Weldy, Chad S; Fishman, Glenn I; Laflamme, Michael A; Chin, Michael T
2014-07-24; 0892-6638,FASEB journal - id: 1072322, year: 2014 JOURNAL ARTICLE

Myogenic bladder defects in mouse models of human oculodentodigital dysplasia
Huang, Tao; Shao, Qing; Barr, Kevin; Simek, Jamie; Fishman, Glenn I; Laird, Dale W
2014-01-20; 0264-6021,Biochemical journal - id: 740852, year: 2014 Journal Article

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression
Josowitz, Rebecca; Lu, Jia; Falce, Christine; D'Souza, Sunita L; Wu, Meng; Cohen, Ninette; Dubois, Nicole C; Zhao, Yong; Sobie, Eric A; Fishman, Glenn I; Gelb, Bruce D
2014-07-25; 1932-6203,PLoS one - id: 1074872, year: 2014 Journal Article

PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
Kim, Eugene E; Shekhar, Akshay; Lu, Jia; Lin, Xianming; Liu, Fang-Yu; Zhang, Jie; Delmar, Mario; Fishman, Glenn I
2014-10-13; 0021-9738,Journal of clinical investigation - id: 1299982, year: 2014 JOURNAL ARTICLE