Irving Fish, M.D.

Asthma and epilepsy: are they related? A retrospective study
Castaneda GY; Heilbroner PL; Shah N; Forem S; Fish I
1998 Jun;13(6):283-285, Journal of child neurology
Numerous studies have suggested that epilepsy and asthma may be related conditions. There has, however, been little epidemiologic data published to support this association. We conducted a retrospective study to determine whether the prevalence of epilepsy is increased among children with asthma, and the prevalence of asthma is increased among children with epilepsy, in comparison with the general pediatric population. We reviewed the medical records, at a large city hospital, of two groups of pediatric outpatients: (1) 400 consecutive patients with asthma followed regularly at the asthma and allergy clinic; and (2) 201 consecutive patients with idiopathic epilepsy followed regularly at the pediatric neurology clinic. Patients with a history of birth prior to 36 weeks' gestational age were excluded. Among the 400 cases of asthma, there were three patients with idiopathic epilepsy (prevalence of 0.75%). The prevalence of epilepsy was similar in mild (0.79%) and moderate-to-severe (0.73%) asthma. Among the 201 cases of idiopathic epilepsy, there were 12 patients with asthma (prevalence of 5.97%). Similar percentages of epilepsy patients with and without asthma reported generalized tonic-clonic, complex partial, simple partial, and myoclonic seizures as their predominant type. The prevalence values in this study are consistent with the prevalence of epilepsy and asthma in the general pediatric population. Our findings therefore suggest that idiopathic epilepsy and asthma are not etiologically related or mutually predisposing conditions. Small samples, failure to exclude patients born prematurely, and the equation of electroencephalographic (EEG) abnormalities with epilepsy may account for the results of previous studies
— id: 7526, year: 1998, vol: 13, page: 283, stat: Journal Article,

Baclofen in the treatment of polymyoclonus in a patient with Unverricht-Lundborg disease
Awaad Y; Fish I
1995 Jan;10(1):68-70, Journal of child neurology
— id: 6571, year: 1995, vol: 10, page: 68, stat: Journal Article,

Baclofen in the treatment of polymyoclonus and ataxia in a patient with homocystinuria
Awaad Y; Sansaricq C; Moroney J; Fish I; Kyriakakos A; Snyderman SE
1995 Jul;10(4):294-296, Journal of child neurology
A patient with homocystinuria due to cystathionine beta-synthase deficiency developed severe progressive polymyoclonus and ataxia. To our knowledge, this is the first time polymyoclonus and ataxia have been reported in association with homocystinuria. Although cerebrovascular thrombosis is usually thought to be responsible for neurologic dysfunction in homocystinuric patients, no infarctions were demonstrated on magnetic resonance imaging scans in our case. We have previously reported that baclofen dramatically improved the polymyoclonus and ataxia in a patient with Unvericht-Lundborg disease. Baclofen given to our patient reversed the polymyoclonus and the ataxia as well. This suggests that patients with polymyoclonus and ataxia, no matter what the etiology, may benefit from the use of baclofen
— id: 6885, year: 1995, vol: 10, page: 294, stat: Journal Article,

Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease
Hosain SA; Hughes JT; Forem SL; Wisoff J; Fish I
1994 Oct;9(4):378-380, Journal of child neurology
Moyamoya disease is a cerebrovascular disease characterized radiologically by progressive narrowing and occlusion of the arteries contributing to the circle of Willis and its branches. There is formation of an exuberant collateral network of blood vessels at the base of the brain, which is thought to arise in response to chronic ischemia. Clinically, the course is variable, with patients having repeated transient ischemic attacks, strokes, migraine, and seizures. Effective treatment is not available. The etiology and pathophysiology of moyamoya disease are largely unknown. Two patients with arteriographically proven moyamoya disease were identified. Both patients were symptomatic before age 5 years. Despite successful encephaloduroarteriosynangiosis revascularization procedures, they continued to experience an inexorable downhill course. A calcium channel blocker (nicardipine HCl) was introduced in order to prevent further symptoms. After the introduction of nicardipine, no further strokes occurred in either patient. There were no further episodes of transient ischemic attacks, seizures, or headache in one patient and decreased frequency in the other. In patients with moyamoya disease, nicardipine may have a beneficial effect on cerebral hemodynamics and may prevent ischemic sequelae by optimizing existing collateral circulation
— id: 56655, year: 1994, vol: 9, page: 378, stat: Journal Article,

Corneal surface irregularities and episodic pain in a patient with mucolipidosis IV
Newman, N J; Starck, T; Kenyon, K R; Lessell, S; Fish, I; Kolodny, E H
1990 Feb;108(2):251-254, Archives of ophthalmology
Mucolipidosis IV is a lysosomal storage disease characterized by prominent involvement of the corneal epithelium. A 5-year-old boy with mucolipidosis IV experienced recurrent episodes of severe ocular pain, tearing, and ipsilateral facial flushing. This was suggestive of reflex sympathetic dystrophy, a syndrome of pain and sympathetic hyperactivity. The examination revealed marked corneal surface irregularities, corresponding to massive accumulations of intracytoplasmic storage material in the epithelium. Episodic pain in patients with mucolipidosis IV is an important symptom, presumably reflecting the distinctive corneal ultrastructural abnormality in this disease
— id: 75037, year: 1990, vol: 108, page: 251, stat: Journal Article,

Pre-natal amino acid transport inhibition: long term influences on behavior and protein metabolism
Samuels, S; Randt, C T; Fish, I; Schwartz, S A
1986 Jan;24(1):143-146, Pharmacology biochemistry & behavior
DBA/2J mice were exposed in utero, between days 15-18 of gestation, to either of two enzyme inhibitors, previously shown to decrease blood-brain, large-neutral amino acid transport in adults: L-methionine-RS-sulfoximine and 2-imidazolidone-4-carboxylic acid. The young mice demonstrated persistently altered motor behavior relative to saline controls when 40-42 days old and evidence of differences in the entry and incorporation of 14C-valine in brain at up to 80 days of age. The findings suggest that interference with blood-brain amino acid transport in utero has long term consequences. This may be related to some human conditions such as maternal phenylketonuria
— id: 106858, year: 1986, vol: 24, page: 143, stat: Journal Article,

ANTI-CONVULSANT ACTIVITY OF GLYCYLGLYCINE AND DELTA- AMINOVALERIC ACID - EVIDENCE FOR GLUTAMINE EXCHANGE IN AMINO- ACID-TRANSPORT
Samuels, S; Fish, I; Schwartz, SA
1983 ;40(4):1063-1068, Journal of neurochemistry
— id: 30666, year: 1983, vol: 40, page: 1063, stat: Journal Article,

AGE-RELATED-CHANGES IN BLOOD-TO-BRAIN AMINO-ACID-TRANSPORT AND INCORPORATION INTO BRAIN PROTEIN
Samuels, S; Fish, I; Schwartz, SA; Hochgeschwender, U
1983 ;8(2):167-177, Neurochemical research
— id: 30660, year: 1983, vol: 8, page: 167, stat: Journal Article,

Progressive sensory loss in familial dysautonomia
Axelrod, F B; Iyer, K; Fish, I; Pearson, J; Sein, M E; Spielholz, N
1981 Apr;67(4):517-522, Pediatrics
Clinical variability in sensory impairment was demonstrated among 75 patients with familial dysautonomia. Older patients had a greater tendency toward increased dysfunction in pain sensation, joint position and Romberg's sign, and vibratory sense. Significant worsening with increased age was supported by retesting of 53 patients after a five-year interval. Sensory and motor axon loss were indicated by electrodiagnostic testing of peripheral nerves and abnormal cortical somatosensory evoked potentials. Familial dysautonomia is a hereditary disease with variable penetrance which involves both failure of intrauterine development of neurons and their postnatal maintenance
— id: 122595, year: 1981, vol: 67, page: 517, stat: Journal Article,

SPARING OF THE BRAIN IN NEONATAL UNDERNUTRITION - AMINO-ACID- TRANSPORT AND INCORPORATION INTO BRAIN AND MUSCLE
Freedman, LS; Samuels, S; Fish, I; Schwartz, SA; Lange, B; Katz, M; Morgano, L
1980 ;207(4433):902-904, Science
— id: 28078, year: 1980, vol: 207, page: 902, stat: Journal Article,

THE GAMMA-GLUTAMYL-TRANSFERASE CYCLE AND AMINO-ACID-TRANSPORT INUTERO
Samuels, S; Fish, I; Randt, CT; Schwartz, SA; Lange, B
1980 ;14(4):461-461, Pediatric research
— id: 28024, year: 1980, vol: 14, page: 461, stat: Journal Article,

PROCEDURE FOR MEASUREMENT OF AMINO-ACID TRANSPORT FROM BLOOD TO BRAIN IN SMALL ANIMALS
Samuels, S; Fish, I
1978 ;87(2):447-454, Analytical biochemistry
— id: 29679, year: 1978, vol: 87, page: 447, stat: Journal Article,

EFFECT OF GAMMA-GLUTAMYL CYCLE INHIBITORS ON BRAIN AMINO-ACID TRANSPORT AND UTILIZATION
Samuels, S; Fish, I; Freedman, LS
1978 ;3(5):619-631, Neurochemical research
— id: 29661, year: 1978, vol: 3, page: 619, stat: Journal Article,

SEXUAL ABUSE AND HERPETIC GENITAL INFECTION IN CHILDREN
Gershon, AA; Fish, I; Borkowsky, W
1976 ;89(2):338-338, Journal of pediatrics
— id: 28747, year: 1976, vol: 89, page: 338, stat: Journal Article,

Amino acid transport inhibition: brain and behavioral correlates
Randt, C T; Samuels, S; Fish, I
1976 Jun;4(6):689-694, Pharmacology biochemistry & behavior
In vivo inhibition of uptake 14C-L-valine by brain following subcutaneous administration of either of two gamma-glutamyl cycle enzyme inhibitors, 2-imidazolidone-4-carboxylic acid (ICA), or, L-methionine-S-sulfoximine (MSO) is documented in C57BL/6J mice. Dose related decrease in exploratory activity, impairment of memory for foot shock, and reduced operant responding for food reinforcement parallels the time course for interference with uptake of a large neutral amino acid by these two compounds previously shown to inhibit different enzymes in the gamma-glutamyl cycle subserving active amino acid transport
— id: 106861, year: 1976, vol: 4, page: 689, stat: Journal Article,

Myelitis associated with genital herpes in a child
Shturman-Ellstein R; Borkowsky W; Fish I; Gershon AA
1976 Mar;88(3):523-523, Journal of pediatrics
— id: 14602, year: 1976, vol: 88, page: 523, stat: Journal Article,

Effect of the antiviral drug, cytosine arabinoside, on the developing nervous system
Ashwal, S; Finegold, M; Fish, I; Budzilovich, G; Brunell, P A
1974 Dec;8(12):945-950, Pediatric research
— id: 117255, year: 1974, vol: 8, page: 945, stat: Journal Article,

Changes in human serum dopamine- -hydroxylase activity with age
Freedman LS; Ohuchi T; Goldstein M; Axelrod F; Fish I; Dancis J
1972 Apr 7;236(5345):310-311, Nature
— id: 43366, year: 1972, vol: 236, page: 310, stat: Journal Article,

Herpes simplex infection of the newborn
Gershon, A A; Fish, I; Brunell, P A
1972 Nov;124(5):739-741, American journal of diseases of children
— id: 122103, year: 1972, vol: 124, page: 739, stat: Journal Article,