Gordon James Fishell

Biosketch / Results /

Gordon James Fishell, Ph.D.

Julius Raynes Professor of Neuroscience and Physiology; Coord Integrated Neuro Prog Smilow Resh Ctr
Departments of Neuroscience and Physiology (Neuro/Phys) and Cell Biology (Skirball)

Contact Info

First Avenue
Floor 5 Room 511
Smilow Research Building
New York, NY 10016

212-263-7691, 212-263-7693

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— Rockefeller University, PostDoctoral Training
— University of Toronto, Graduate Education
— Columbia University, PostDoctoral Training

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Research Summary

The telencephalon both houses the highest level of neural processing and is the most phylogentically divergent structure in the CNS. In adult mammals, the dorsal pallial telencephalon gives rise to the laminar, cortical regions of brain, whereas the ventral aspect develops into the nuclear components of the basal ganglia. We are interested in investigating how these regional differences arise.

What then are the cellular and molecular mechanisms involved in the establishment of the regional organization of the forebrain. Central to this problem is identifying when cells within forebrain are committed to a specific regional phenotype. To address this question, we previously initiated a series of in vivo grafting experiments using forebrain progenitors from a variety of developmental stages from early to late neurogenesis. (Fishell, 1995, Na et al., 1998). We observed that while individual progenitors maintain their anterior-posterior (A-P) identity after transplantation, their dorsal-ventral (D-V) identity remains plastic. This suggests that forebrain progenitors contain intrinsic A-P information that dictates their response to more ubiquitous D-V cues, such as Shh and BMPs.

Establishing D-V pattern within telencephalon involves two complementary processes: the expression of regional phenotypes and a concommitant change in cell proliferation. How these two processes are coordinately regulated is at present poorly understood. Nonetheless, candidate molecules for regulating each of these processes have been identified. We have begun to experimentally test the role of both genes with regional patterns of expression; as well as genes in the lateral signalling pathway , which have been shown to be involved in patterns of proliferation and differentiation. Genes involved in regional patterning which we are investigating include the transcription factors Dlx2 and Emx1 and the signaling molecules sonic hedgehog and FGF8. Members of the lateral signaling pathway that we are currently examining includes, Notch, Delta, JkRBP and Numb. We are currently using gene targeting methods as a means of examining both gain of function and loss of function phenotypes in the telencephalon.. In addition, we are presently testing the function of both of these classes of genes through ectopic expression studies, using both in vivo and in vitro approaches. To this end, we have devised methods to use viral vectors to etopically express genes in mouse embryos in utero, using a novel high resolution ultrasound-guided injection system (developed by Dr. Dan Turnbull). This has allowed us to gain access to the forebrain at stages before neurogenesis (embryonic day 9.5, E9.5) As a complement to this work we are also using in vitro forebrain explant cultures from stages prior to when in utero manipulations are possible.

It is clear that regional patterning in the CNS results from an active interplay of regional patterning, combined with control of local patterns of proliferation. Our present experiments are allowing us to take an experimental approach, aimed at dissecting the mechanisms by which these processes are regulated within the telencepahlon.

Research Interests

Mechanisms of Neural Patterning in Mammalian Forebrain

Research Keywords

forebrain, gene expression, neurogenic patterns, telencephalon

Research Documents

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All data from NYU Health Sciences Library Faculty Bibliography — -


Subtype-selective Electroporation of Cortical Interneurons
De Marco Garcia, Natalia V; Fishell, Gord
2014 ;(90):e51518-e51518 E19, Journal of visualized experiments : JoVE
— id: 1173722, year: 2014, vol: , page: e51518, stat: Journal Article,

Inhibition: synapses, neurons and circuits
Fishell, Gord; Tamas, Gabor
2014 Jun;26:v-vii, Current opinion in neurobiology
— id: 1004882, year: 2014, vol: 26, page: v, stat: Journal Article,

Astrocyte activation is suppressed in both normal and injured brain by FGF signaling
Kang, Wenfei; Balordi, Francesca; Su, Nan; Chen, Lin; Fishell, Gordon; Hebert, Jean M
2014 Jul;111(29):E2987-E2995, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 1127392, year: 2014, vol: 111, page: E2987, stat: Journal Article,

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission
Karayannis, T; Au, E; Patel, J C; Kruglikov, I; Markx, S; Delorme, R; Heron, D; Salomon, D; Glessner, J; Restituito, S; Gordon, A; Rodriguez-Murillo, L; Roy, N C; Gogos, J A; Rudy, B; Rice, M E; Karayiorgou, M; Hakonarson, H; Keren, B; Huguet, G; Bourgeron, T; Hoeffer, C; Tsien, R W; Peles, E; Fishell, G
2014 Jul;511(7508):236-240, Nature
— id: 1102842, year: 2014, vol: 511, page: 236, stat: Journal Article,

Interneuron cell types are fit to function
Kepecs, Adam; Fishell, Gordon
2014 Jan;505(7483):318-326, Nature
— id: 741292, year: 2014, vol: 505, page: 318, stat: Journal Article,

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning
Sakamoto, Masayuki; Ieki, Nao; Miyoshi, Goichi; Mochimaru, Daisuke; Miyachi, Hitoshi; Imura, Tetsuya; Yamaguchi, Masahiro; Fishell, Gord; Mori, Kensaku; Kageyama, Ryoichiro; Imayoshi, Itaru
2014 Apr;34(17):5788-5799, Journal of neuroscience
— id: 918042, year: 2014, vol: 34, page: 5788, stat: Journal Article,

miRNAs are Essential for the Survival and Maturation of Cortical Interneurons
Tuncdemir, Sebnem N; Fishell, Gord; Batista-Brito, Renata
2014 Jan;:207-225, Cerebral cortex
— id: 900382, year: 2014, vol: , page: 207, stat: Journal Article,

A Modular Gain-of-Function Approach to Generate Cortical Interneuron Subtypes from ES Cells
Au, Edmund; Ahmed, Tanzeel; Karayannis, Theofanis; Biswas, Shiona; Gan, Lin; Fishell, Gord
2013 Dec;80(5):1145-1158, Neuron
— id: 670932, year: 2013, vol: 80, page: 1145, stat: Journal Article,

Reverse Pharmacogenetic Modulation of the Nucleus Accumbens Reduces Ethanol Consumption in a Limited Access Paradigm
Cassataro, Daniela; Bergfeldt, Daniella; Malekian, Cariz; Van Snellenberg, Jared X; Thanos, Panayotis K; Fishell, Gord; Sjulson, Lucas
2013 Aug;:121-123, Neuropsychopharmacology
— id: 622332, year: 2013, vol: , page: 121, stat: Journal Article,

New insights into the classification and nomenclature of cortical GABAergic interneurons
Defelipe, Javier; Lopez-Cruz, Pedro L; Benavides-Piccione, Ruth; Bielza, Concha; Larranaga, Pedro; Anderson, Stewart; Burkhalter, Andreas; Cauli, Bruno; Fairen, Alfonso; Feldmeyer, Dirk; Fishell, Gord; Fitzpatrick, David; Freund, Tamas F; Gonzalez-Burgos, Guillermo; Hestrin, Shaul; Hill, Sean; Hof, Patrick R; Huang, Josh; Jones, Edward G; Kawaguchi, Yasuo; Kisvarday, Zoltan; Kubota, Yoshiyuki; Lewis, David A; Marin, Oscar; Markram, Henry; McBain, Chris J; Meyer, Hanno S; Monyer, Hannah; Nelson, Sacha B; Rockland, Kathleen; Rossier, Jean; Rubenstein, John L R; Rudy, Bernardo; Scanziani, Massimo; Shepherd, Gordon M; Sherwood, Chet C; Staiger, Jochen F; Tamas, Gabor; Thomson, Alex; Wang, Yun; Yuste, Rafael; Ascoli, Giorgio A
2013 Mar;14(3):202-216, Nature reviews. Neuroscience
— id: 250672, year: 2013, vol: 14, page: 202, stat: Journal Article,

The neuron identity problem: form meets function
Fishell, Gord; Heintz, Nathaniel
2013 Oct;80(3):602-612, Neuron
— id: 670942, year: 2013, vol: 80, page: 602, stat: Journal Article,

Hurricane Sandy: After the deluge
Fishell, Gordon
2013 Apr;496(7446):421-422, Nature
— id: 489642, year: 2013, vol: 496, page: 421, stat: Journal Article,

A foot in the door: how the chromatin modifier Brg1 and Pax6 jointly potentiate adult neurogenesis
Jaglin, Xavier H; Fishell, Gord
2013 Oct;13(4):373-374, Cell stem cell
— id: 670952, year: 2013, vol: 13, page: 373, stat: Journal Article,

A disinhibitory circuit mediates motor integration in the somatosensory cortex
Lee, Soohyun; Kruglikov, Illya; Huang, Z Josh; Fishell, Gord; Rudy, Bernardo
2013 Nov;16(11):1662-1670, Nature neuroscience
— id: 598452, year: 2013, vol: 16, page: 1662, stat: Journal Article,

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons
Owen, Scott F; Tuncdemir, Sebnem N; Bader, Patrick L; Tirko, Natasha N; Fishell, Gord; Tsien, Richard W
2013 Aug;:458-462, Nature
— id: 489582, year: 2013, vol: , page: 458, stat: Journal Article,

Ca 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures
Rossignol, Elsa; Kruglikov, Illya; van den Maagdenberg, Arn M J M; Rudy, Bernardo; Fishell, Gord
2013 Apr;:81-93, Annals of neurology
— id: 425942, year: 2013, vol: , page: 81, stat: Journal Article,

Cav2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures
Rossignol, Elsa; Kruglikov, Illya; van den Maagdenberg, Arn M. J. M; Rudy, Bernardo; Fishell, Gord
2013 ;74(2):209-222, Annals of neurology
— id: 670882, year: 2013, vol: 74, page: 209, stat: Journal Article,

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1
van den Berghe, Veronique; Stappers, Elke; Vandesande, Bram; Dimidschstein, Jordane; Kroes, Roel; Francis, Annick; Conidi, Andrea; Lesage, Flore; Dries, Ruben; Cazzola, Silvia; Berx, Geert; Kessaris, Nicoletta; Vanderhaeghen, Pierre; van Ijcken, Wilfred; Grosveld, Frank G; Goossens, Steven; Haigh, Jody J; Fishell, Gord; Goffinet, Andre; Aerts, Stein; Huylebroeck, Danny; Seuntjens, Eve
2013 Jan;77(1):70-82, Neuron
— id: 670962, year: 2013, vol: 77, page: 70, stat: Journal Article,

Dynamic changes in interneuron morphophysiological properties mark the maturation of hippocampal network activity
Allene, Camille; Picardo, Michel A; Becq, Helene; Miyoshi, Goichi; Fishell, Gord; Cossart, Rosa
2012 May;32(19):6688-6698, Journal of neuroscience
— id: 166806, year: 2012, vol: 32, page: 6688, stat: Journal Article,

Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons
Close, Jennie; Xu, Han; De Marco Garcia, Natalia; Batista-Brito, Renata; Rossignol, Elsa; Rudy, Bernardo; Fishell, Gord
2012 Dec;32(49):17690-17705, Journal of neuroscience
— id: 202462, year: 2012, vol: 32, page: 17690, stat: Journal Article,

The origin of neocortical nitric oxide synthase-expressing inhibitory neurons
Jaglin, Xavier H; Hjerling-Leffler, Jens; Fishell, Gord; Batista-Brito, Renata
2012 ;6:44-44, Frontiers in neural circuits
— id: 175780, year: 2012, vol: 6, page: 44, stat: Journal Article,

Functional adaptation of cortical interneurons to attenuated activity is subtype-specific
Karayannis, Theofanis; De Marco Garcia, Natalia V; Fishell, Gordon J
2012 ;6:66-66, Frontiers in neural circuits
— id: 178855, year: 2012, vol: 6, page: 66, stat: Journal Article,

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, Daniel A; Bedont, Joseph L; Pak, Thomas; Wang, Hong; Song, Juan; Miranda-Angulo, Ana; Takiar, Vani; Charubhumi, Vanessa; Balordi, Francesca; Takebayashi, Hirohide; Aja, Susan; Ford, Eric; Fishell, Gordon; Blackshaw, Seth
2012 ;15(5):700-702, Nature neuroscience
— id: 166883, year: 2012, vol: 15, page: 700, stat: Journal Article,

Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus
Marissal, Thomas; Bonifazi, Paolo; Picardo, Michel Aime; Nardou, Romain; Petit, Ludovic Franck; Baude, Agnes; Fishell, Gordon James; Ben-Ari, Yehezkel; Cossart, Rosa
2012 ;3:1316-1316, Nature communications
— id: 489652, year: 2012, vol: 3, page: 1316, stat: Journal Article,

Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate
Miyoshi, Goichi; Fishell, Gord
2012 Jun;74(6):1045-1058, Neuron
— id: 172994, year: 2012, vol: 74, page: 1045, stat: Journal Article,

Neuronal activity is required for the development of specific cortical interneuron subtypes
De Marco Garcia, Natalia V; Karayannis, Theofanis; Fishell, Gord
2011 Apr 21;472(7343):351-355, Nature
— id: 131814, year: 2011, vol: 472, page: 351, stat: Journal Article,

Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus
Encinas, Juan M; Michurina, Tatyana V; Peunova, Natalia; Park, June-Hee; Tordo, Julie; Peterson, Daniel A; Fishell, Gord; Koulakov, Alex; Enikolopov, Grigori
2011 May 6;8(5):566-579, Cell stem cell
— id: 133415, year: 2011, vol: 8, page: 566, stat: Journal Article,

Mechanisms of Inhibition within the Telencephalon: "Where the Wild Things Are"
Fishell, Gord; Rudy, Bernardo
2011 ;34:535-567, Annual review of neuroscience
— id: 134442, year: 2011, vol: 34, page: 535, stat: Journal Article,

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip
Machold, R; Klein, C; Fishell, G
2011 Jun-Jul;11(5-6):349-359, Gene expression patterns
— id: 132573, year: 2011, vol: 11, page: 349, stat: Journal Article,

Introduction to the special issue on cortical interneurons
McBain, Chris J; Fishell, Gord
2011 Jan 1;71(1):1-1, Developmental neurobiology
— id: 149516, year: 2011, vol: 71, page: 1, stat: Journal Article,

GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal Development
Miyoshi, Goichi; Fishell, Gord
2011 Apr;21(4):845-852, Cerebral cortex
— id: 128784, year: 2011, vol: 21, page: 845, stat: Journal Article,

Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus
Picardo, Michel Aime; Guigue, Philippe; Bonifazi, Paolo; Batista-Brito, Renata; Allene, Camille; Ribas, Alain; Fishell, Gord; Baude, Agnes; Cossart, Rosa
2011 Aug 25;71(4):695-709, Neuron
— id: 149515, year: 2011, vol: 71, page: 695, stat: Journal Article,

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, Bernardo; Fishell, Gordon; Lee, Soohyun; Hjerling-Leffler, Jens
2011 Jan 1;71(1):45-61, Developmental neurobiology
— id: 115434, year: 2011, vol: 71, page: 45, stat: Journal Article,

A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, Hiroki; He, Miao; Wu, Priscilla; Kim, Sangyong; Paik, Raehum; Sugino, Ken; Kvitsani, Duda; Fu, Yu; Lu, Jiangteng; Lin, Ying; Miyoshi, Goichi; Shima, Yasuyuki; Fishell, Gord; Nelson, Sacha B; Huang, Z Josh
2011 Sep 22;71(6):995-1013, Neuron
— id: 138980, year: 2011, vol: 71, page: 995, stat: Journal Article,

Neural circuits look forward
Tuncdemir, Sebnem N; Fishell, Gord
2011 Sep 27;108(39):16137-16138, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 137888, year: 2011, vol: 108, page: 16137, stat: Journal Article,

Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala
Carney, Rosalind S E; Mangin, Jean-Marie; Hayes, Lindsay; Mansfield, Kevin; Sousa, Vitor H; Fishell, Gord; Machold, Robert P; Ahn, Sohyun; Gallo, Vittorio; Corbin, Joshua G
2010 ;5:14-14, Neural development
— id: 119206, year: 2010, vol: 5, page: 14, stat: Journal Article,

Cerebral cortex: Symmetric vs: asymmetric cell division
Fishell, G; Hanashima, C
Encyclopedia of Neuroscience Berlin: Elsevier, 2009,
— id: 656222, year: 2010, vol: , page: 785, stat: Chapter,

A silver lining to stroke: does ischemia generate new cortical interneurons?
Fishell, Gord; Goldman, James E
2010 Feb;13(2):145-146, Nature neuroscience
— id: 106379, year: 2010, vol: 13, page: 145, stat: Journal Article,

Previews. Inhibition as a transplant-mediated therapy: a new paradigm for treating Parkinson's?
Karayannis, Theofanis; Fishell, Gordon
2010 Mar 5;6(3):184-185, Cell stem cell
— id: 108431, year: 2010, vol: 6, page: 184, stat: Journal Article,

The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
Lee, Soohyun; Hjerling-Leffler, Jens; Zagha, Edward; Fishell, Gord; Rudy, Bernardo
2010 Dec 15;30(50):16796-16808, Journal of neuroscience
— id: 115436, year: 2010, vol: 30, page: 16796, stat: Journal Article,

Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons
Miyoshi, Goichi; Hjerling-Leffler, Jens; Karayannis, Theofanis; Sousa, Vitor H; Butt, Simon J B; Battiste, James; Johnson, Jane E; Machold, Robert P; Fishell, Gord
2010 Feb 3;30(5):1582-1594, Journal of neuroscience
— id: 106515, year: 2010, vol: 30, page: 1582, stat: Journal Article,

Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Sousa, Vitor H; Fishell, Gord
2010 Aug;20(4):391-399, Current opinion in genetics & development
— id: 111348, year: 2010, vol: 20, page: 391, stat: Journal Article,

Common origins of hippocampal Ivy and nitric oxide synthase expressing neurogliaform cells
Tricoire, Ludovic; Pelkey, Kenneth A; Daw, Michael I; Sousa, Vitor H; Miyoshi, Goichi; Jeffries, Brian; Cauli, Bruno; Fishell, Gord; McBain, Chris J
2010 Feb 10;30(6):2165-2176, Journal of neuroscience
— id: 149518, year: 2010, vol: 30, page: 2165, stat: Journal Article,

Chapter 3 the developmental integration of cortical interneurons into a functional network
Batista-Brito, Renata; Fishell, Gord
2009 ;87:81-118, Current topics in developmental biology
— id: 98905, year: 2009, vol: 87, page: 81, stat: Journal Article,

The cell-intrinsic requirement of Sox6 for cortical interneuron development
Batista-Brito, Renata; Rossignol, Elsa; Hjerling-Leffler, Jens; Denaxa, Myrto; Wegner, Michael; Lefebvre, Veronique; Pachnis, Vassilis; Fishell, Gord
2009 Aug 27;63(4):466-481, Neuron
— id: 101904, year: 2009, vol: 63, page: 466, stat: Journal Article,

Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala
Cocas, Laura A; Miyoshi, Goichi; Carney, Rosalind S E; Sousa, Vitor H; Hirata, Tsutomu; Jones, Kevin R; Fishell, Gord; Huntsman, Molly M; Corbin, Joshua G
2009 Dec 16;29(50):15933-15946, Journal of neuroscience
— id: 105981, year: 2009, vol: 29, page: 15933, stat: Journal Article,

Cortical development: neural stem cells to neural circuits : Chania, Greece, May 22-25, 2008
Fishell, Gord
Oxford [u.a.] : Oxford University Press, 2009,
— id: 1061802, year: 2009, vol: , page: , stat: ,

Math1: waiting to inhale
Machold, Robert P; Fishell, Gord
2009 Nov 12;64(3):293-295, Neuron
— id: 105344, year: 2009, vol: 64, page: 293, stat: Journal Article,

Characterization of Nkx6-2-derived neocortical interneuron lineages
Sousa, Vitor H; Miyoshi, Goichi; Hjerling-Leffler, Jens; Karayannis, Theofanis; Fishell, Gord
2009 Jul;19 Suppl 1:i1-10, Cerebral cortex
— id: 149519, year: 2009, vol: 19 Suppl 1, page: i1, stat: Journal Article,

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
Ascoli, Giorgio A; Alonso-Nanclares, Lidia; Anderson, Stewart A; Barrionuevo, German; Benavides-Piccione, Ruth; Burkhalter, Andreas; Buzsaki, Gyorgy; Cauli, Bruno; Defelipe, Javier; Fairen, Alfonso; Feldmeyer, Dirk; Fishell, Gord; Fregnac, Yves; Freund, Tamas F; Gardner, Daniel; Gardner, Esther P; Goldberg, Jesse H; Helmstaedter, Moritz; Hestrin, Shaul; Karube, Fuyuki; Kisvarday, Zoltan F; Lambolez, Bertrand; Lewis, David A; Marin, Oscar; Markram, Henry; Munoz, Alberto; Packer, Adam; Petersen, Carl C H; Rockland, Kathleen S; Rossier, Jean; Rudy, Bernardo; Somogyi, Peter; Staiger, Jochen F; Tamas, Gabor; Thomson, Alex M; Toledo-Rodriguez, Maria; Wang, Yun; West, David C; Yuste, Rafael
2008 Jul;9(7):557-568, Nature reviews. Neuroscience
— id: 94591, year: 2008, vol: 9, page: 557, stat: Journal Article,

Cortex shatters the glass ceiling
Au, Edmund; Fishell, Gord
2008 Nov 6;3(5):472-474, Cell stem cell
— id: 149520, year: 2008, vol: 3, page: 472, stat: Journal Article,

Choices in neuroscience careers
Bartfai, Tamas; Insel, Tom; Fishell, Gord; Rothwell, Nancy
2008 May;9(5):401-405, Nature reviews. Neuroscience
— id: 149523, year: 2008, vol: 9, page: 401, stat: Journal Article,

The distinct temporal origins of olfactory bulb interneuron subtypes
Batista-Brito, Renata; Close, Jennie; Machold, Robert; Fishell, Gord
2008 Apr 9;28(15):3966-3975, Journal of neuroscience
— id: 78698, year: 2008, vol: 28, page: 3966, stat: Journal Article,

Gene expression in cortical interneuron precursors is prescient of their mature function
Batista-Brito, Renata; Machold, Robert; Klein, Corinna; Fishell, Gord
2008 Oct;18(10):2306-2317, Cerebral cortex
— id: 91427, year: 2008, vol: 18, page: 2306, stat: Journal Article,

The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, Simon J B; Sousa, Vitor H; Fuccillo, Marc V; Hjerling-Leffler, Jens; Miyoshi, Goichi; Kimura, Shioko; Fishell, Gord
2008 Sep 11;59(5):722-732, Neuron
— id: 89477, year: 2008, vol: 59, page: 722, stat: Journal Article,

Pyramidal neurons grow up and change their mind
Fishell, Gord; Hanashima, Carina
2008 Feb 7;57(3):333-338, Neuron
— id: 78689, year: 2008, vol: 57, page: 333, stat: Journal Article,

Genetic approaches identify adult pituitary stem cells
Gleiberman, Anatoli S; Michurina, Tatyana; Encinas, Juan M; Roig, Jose L; Krasnov, Peter; Balordi, Francesca; Fishell, Gord; Rosenfeld, Michael G; Enikolopov, Grigori
2008 Apr 29;105(17):6332-6337, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 135304, year: 2008, vol: 105, page: 6332, stat: Journal Article,

The genetics of early telencephalon patterning: some assembly required
Hebert, Jean M; Fishell, Gord
2008 Sep;9(9):678-685, Nature reviews. Neuroscience
— id: 149521, year: 2008, vol: 9, page: 678, stat: Journal Article,

Luo, LQ; Fishell, G
2008 FEB ;18(1):1-3, Current opinion in neurobiology
— id: 86848, year: 2008, vol: 18, page: 1, stat: Journal Article,

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Yang, Zeng-Jie; Ellis, Tammy; Markant, Shirley L; Read, Tracy-Ann; Kessler, Jessica D; Bourboulas, Melissa; Schuller, Ulrich; Machold, Robert; Fishell, Gord; Rowitch, David H; Wainwright, Brandon J; Wechsler-Reya, Robert J
2008 Aug 12;14(2):135-145, Cancer cell
— id: 149522, year: 2008, vol: 14, page: 135, stat: Journal Article,

Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons
Balordi, Francesca; Fishell, Gord
2007 May 30;27(22):5936-5947, Journal of neuroscience
— id: 72879, year: 2007, vol: 27, page: 5936, stat: Journal Article,

Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal
Balordi, Francesca; Fishell, Gord
2007 Dec 26;27(52):14248-14259, Journal of neuroscience
— id: 75773, year: 2007, vol: 27, page: 14248, stat: Journal Article,

Making up your mind : developmental origins of cortical interneurons
Fishell, Gordon
[S.l.] : NIH, 2007,
— id: 1428, year: 2007, vol: , page: , stat: ,

Perspectives on the developmental origins of cortical interneuron diversity
Fishell, Gordon
2007 ;288:24-29, Novartis foundation symposium
— id: 79564, year: 2007, vol: 288, page: 24, stat: Journal Article,

The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes
Hanashima, Carina; Fernandes, Marie; Hebert, Jean M; Fishell, Gord
2007 Oct 10;27(41):11103-11111, Journal of neuroscience
— id: 149524, year: 2007, vol: 27, page: 11103, stat: Journal Article,

Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip
Machold, Robert P; Kittell, Deborah Jones; Fishell, Gordon J
2007 ;2:5-5, Neural development
— id: 72050, year: 2007, vol: 2, page: 5, stat: Journal Article,

Development of brainstem and cerebellar neurons originating from the rhombic lip
Machold, RP; Fishell, GF
2007 AUG ;102(3):174-175, Journal of neurochemistry
— id: 74184, year: 2007, vol: 102, page: 174, stat: Journal Article,

Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors
Miyoshi, Goichi; Butt, Simon J B; Takebayashi, Hirohide; Fishell, Gord
2007 Jul 18;27(29):7786-7798, Journal of neuroscience
— id: 73583, year: 2007, vol: 27, page: 7786, stat: Journal Article,

Adult cortical neurogenesis: nuanced, negligible or nonexistent?
Au, Edmund; Fishell, Gord
2006 Sep;9(9):1086-1088, Nature neuroscience
— id: 68282, year: 2006, vol: 9, page: 1086, stat: Journal Article,

Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system
Carney, Rosalind S E; Alfonso, Teresa B; Cohen, Daniela; Dai, Haining; Nery, Susana; Stoica, Bogdan; Slotkin, Jonathan; Bregman, Barbara S; Fishell, Gord; Corbin, Joshua G
2006 Nov 8;26(45):11562-11574, Journal of neuroscience
— id: 149525, year: 2006, vol: 26, page: 11562, stat: Journal Article,

Functional genomics of early cortex patterning
Chambers, David; Fishell, Gord
2006 ;7(1):202-202, Genome biology
— id: 68283, year: 2006, vol: 7, page: 202, stat: Journal Article,

Loss of a notch activity in the developing central nervous system leads to increased cell death
Fishell, Gord
2006 ;28(6):517-517, Developmental neuroscience
— id: 73600, year: 2006, vol: 28, page: 517, stat: Journal Article,

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development (vol 7, pg 772, 2006)
Fuccillo, M; Joyner, AL; Fishell, G
2006 ;7(11):902-902, Nature reviews. Neuroscience
— id: 104592, year: 2006, vol: 7, page: 902, stat: Journal Article,

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Fuccillo, Marc; Joyner, Alexandra L; Fishell, Gord
2006 Oct;7(10):772-783, Nature reviews. Neuroscience
— id: 69028, year: 2006, vol: 7, page: 772, stat: Journal Article,

Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice
Fuccillo, Marc; Rutlin, Michael; Fishell, Gord
2006 Jul;16 Suppl 1:i96-102, Cerebral cortex
— id: 67004, year: 2006, vol: 16 Suppl 1, page: i96, stat: Journal Article,

Building bridges to the cortex
Hanashima, Carina; Molnar, Zoltan; Fishell, Gord
2006 Apr 7;125(1):24-27, Cell
— id: 64172, year: 2006, vol: 125, page: 24, stat: Journal Article,

Cell fate specification and axonogenesis in neurons fate mapped from the embryonic rhombic lip
Machold, R; Klein, C; Fishell, G
2006 DEC ;24(8):524-524, International journal of developmental neuroscience
— id: 71046, year: 2006, vol: 24, page: 524, stat: Journal Article,

Loss of notch activity in the developing central nervous system leads to increased cell death
Mason, Heather A; Rakowiecki, Staci M; Gridley, Thomas; Fishell, Gord
2006 ;28(1-2):49-57, Developmental neuroscience
— id: 64388, year: 2006, vol: 28, page: 49, stat: Journal Article,

Directing neuron-specific transgene expression in the mouse CNS
Miyoshi, Goichi; Fishell, Gord
2006 Oct;16(5):577-584, Current opinion in neurobiology
— id: 69590, year: 2006, vol: 16, page: 577, stat: Journal Article,

Lineage-restricted progenitors can serve as cells of origin for medulloblastoma
Yang, ZJ; Read, TA; Ellis, T; Machold, R; Fishell, G; Rowitch, DH; Wainwright, BJ; Wechsler-Reya, RJ
2006 OCT ;8(4):471-471, Neuro-oncology
— id: 70329, year: 2006, vol: 8, page: 471, stat: Journal Article,

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
Anthony, Todd E; Mason, Heather A; Gridley, Thomas; Fishell, Gord; Heintz, Nathaniel
2005 May 1;19(9):1028-1033, Genes & development
— id: 68285, year: 2005, vol: 19, page: 1028, stat: Journal Article,

The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, Simon J B; Fuccillo, Marc; Nery, Susana; Noctor, Steven; Kriegstein, Arnold; Corbin, Joshua G; Fishell, Gord
2005 Nov 23;48(4):591-604, Neuron
— id: 61423, year: 2005, vol: 48, page: 591, stat: Journal Article,

Cerebellum- and forebrain-derived stem cells possess intrinsic regional character
Klein, Corinna; Butt, Simon J B; Machold, Robert P; Johnson, Jane E; Fishell, Gord
2005 Oct;132(20):4497-4508, Development
— id: 68284, year: 2005, vol: 132, page: 4497, stat: Journal Article,

Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
Machold, Rob; Fishell, Gord
2005 Oct 6;48(1):17-24, Neuron
— id: 61336, year: 2005, vol: 48, page: 17, stat: Journal Article,

Notch signaling coordinates the patterning of striatal compartments
Mason, Heather A; Rakowiecki, Staci M; Raftopoulou, Myrto; Nery, Susana; Huang, Yuanyuan; Gridley, Thomas; Fishell, Gord
2005 Oct;132(19):4247-4258, Development
— id: 61255, year: 2005, vol: 132, page: 4247, stat: Journal Article,

Radial glia serve as neuronal progenitors in all regions of the central nervous system
Anthony, Todd E; Klein, Corinna; Fishell, Gord; Heintz, Nathaniel
2004 Mar 25;41(6):881-890, Neuron
— id: 68288, year: 2004, vol: 41, page: 881, stat: Journal Article,

Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene
Kohtz, Jhumku D; Fishell, Gord
2004 Jul;4(4):407-412, Gene expression patterns
— id: 68287, year: 2004, vol: 4, page: 407, stat: Journal Article,

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors
Yoon, Keejung; Nery, Susana; Rutlin, Michael L; Radtke, Freddy; Fishell, Gord; Gaiano, Nicholas
2004 Oct 27;24(43):9497-9506, Journal of neuroscience
— id: 68286, year: 2004, vol: 24, page: 9497, stat: Journal Article,

Hedgehog patterns midbrain ARChitecture
Machold, Robert; Fishell, Gord
2002 Jan;25(1):10-11, Trends in neurosciences
— id: 68289, year: 2002, vol: 25, page: 10, stat: Journal Article,

Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors
Chambers CB; Peng Y; Nguyen H; Gaiano N; Fishell G; Nye JS
2001 Mar;128(5):689-702, Development
— id: 20804, year: 2001, vol: 128, page: 689, stat: Journal Article,

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
Kohtz, J D; Lee, H Y; Gaiano, N; Segal, J; Ng, E; Larson, T; Baker, D P; Garber, E A; Williams, K P; Fishell, G
2001 Jun;128(12):2351-2363, Development
— id: 68290, year: 2001, vol: 128, page: 2351, stat: Journal Article,

An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
Lee JD; Kraus P; Gaiano N; Nery S; Kohtz J; Fishell G; Loomis CA; Treisman JE
2001 May 1;233(1):122-136, Developmental biology (Orlando)
— id: 20707, year: 2001, vol: 233, page: 122, stat: Journal Article,

Calcium-dependent adhesion is necessary for the maintenance of prosomeres
McCarthy M; Na E; Neyt C; Langston A; Fishell G
2001 May 1;233(1):80-94, Developmental biology (Orlando)
— id: 20708, year: 2001, vol: 233, page: 80, stat: Journal Article,

Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain
Nery S; Wichterle H; Fishell G
2001 Feb;128(4):527-540, Development
— id: 20805, year: 2001, vol: 128, page: 527, stat: Journal Article,

The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
Corbin JG; Gaiano N; Machold RP; Langston A; Fishell G
2000 Dec;127(23):5007-5020, Development
— id: 20806, year: 2000, vol: 127, page: 5007, stat: Journal Article,

Radial glial identity is promoted by Notch1 signaling in the murine forebrain
Gaiano N; Nye JS; Fishell G
2000 May;26(2):395-404, Neuron
— id: 11669, year: 2000, vol: 26, page: 395, stat: Journal Article,

A method for rapid gain-of-function studies in the mouse embryonic nervous system [see comments]
Gaiano N; Kohtz JD; Turnbull DH; Fishell G
1999 Sep;2(9):812-819, Nature neuroscience
— id: 8484, year: 1999, vol: 2, page: 812, stat: Journal Article,

Generation of a radial-like glial cell line
Friedlander DR; Brittis PA; Sakurai T; Shif B; Wirchansky W; Fishell G; Grumet M
1998 Nov 5;37(2):291-304, Journal of neurobiology
— id: 7568, year: 1998, vol: 37, page: 291, stat: Journal Article,

Transplantation as a tool to study progenitors within the vertebrate nervous system
Gaiano N; Fishell G
1998 Aug;36(2):152-161, Journal of neurobiology
— id: 7571, year: 1998, vol: 36, page: 152, stat: Journal Article,

Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
Kohtz JD; Baker DP; Corte G; Fishell G
1998 Dec;125(24):5079-5089, Development
— id: 7374, year: 1998, vol: 125, page: 5079, stat: Journal Article,

Telencephalic progenitors maintain anteroposterior identities cell autonomously
Na E; McCarthy M; Neyt C; Lai E; Fishell G
1998 Aug 27;8(17):987-990, Current biology. CB
— id: 7700, year: 1998, vol: 8, page: 987, stat: Journal Article,

Cooperation of intrinsic and extrinsic signals in the elaboration of regional identity in the posterior cerebral cortex
Nothias F; Fishell G; Ruiz i Altaba A
1998 Apr 9;8(8):459-462, Current biology. CB
— id: 7719, year: 1998, vol: 8, page: 459, stat: Journal Article,

Regionalization in the mammalian telencephalon
Fishell G
1997 Feb;7(1):62-69, Current opinion in neurobiology
— id: 12386, year: 1997, vol: 7, page: 62, stat: Journal Article,

Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis
Lim DA; Fishell GJ; Alvarez-Buylla A
1997 Dec 23;94(26):14832-14836, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 7659, year: 1997, vol: 94, page: 14832, stat: Journal Article,

A short-range signal restricts cell movement between telencephalic proliferative zones
Neyt C; Welch M; Langston A; Kohtz J; Fishell G
1997 Dec 1;17(23):9194-9203, Journal of neuroscience
— id: 8244, year: 1997, vol: 17, page: 9194, stat: Journal Article,

Ultrasound-guided injections into the mouse embryonic brain
Turnbull, DH; Olsson, M; Fishell, G; Joyner, AL
1997 ;62(2):1485-1488, Proceedings (IEEE Ultrasonics Symposium)
— id: 104604, year: 1997, vol: 62, page: 1485, stat: Journal Article,

Striatal precursors adopt cortical identities in response to local cues
Fishell G
1995 Mar;121(3):803-812, Development
— id: 7897, year: 1995, vol: 121, page: 803, stat: Journal Article,

Dispersion of neural progenitors within the germinal zones of the forebrain [published erratum appears in Nature 1993 May 20;363(6426):286] [see comments]
Fishell G; Mason CA; Hatten ME
1993 Apr 15;362(6421):636-638, Nature
— id: 8520, year: 1993, vol: 362, page: 636, stat: Journal Article,