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Carlos Fernandez-Hernando

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Carlos Fernandez-Hernando, Ph.D.

Assistant Professor;
Departments of Medicine (Cardio Div) and Cell Biology (Cell Biology)

Contact Info

Address
522 First Avenue
Floor 8 Room 804
Smilow Research Building
New York, NY 10016

Phone: 212-263-9324
Email: Carlos.Fernandez-Hernando@nyumc.org

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Education

1993-1998 — Universidad Autonoma de Madrid, Graduate Education
1999-2004 — Hospital Ramon y Cajal, Universidad Autonoma de Madrid, Graduate Education
2005-2009 — Yale University School of Medicine, PostDoctoral Training

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Research Interests

Our primary research interest lies in the area of cholesterol metabolism and atherosclerosis. Our future research plans involve studying the intracellular cholesterol trafficking and the role of Akt-1 in the progression of atherosclerosis. Additionally, I seek to determine the role of microRNAs on cholesterol metabolism and related cardiovascular disorders. These areas of investigation are necessary not only because they address fundamentally important questions relating to cholesterol metabolism, but also because a better characterization of these processes may lead to improvements in current therapies. In the future, we plan to continue our research in the following three specific areas: 1. Define the role of microRNAs on cholesterol metabolism and atherosclerosis MicroRNAs (miRNAs) are short (~22nt) noncoding RNAs derived from long primary transcrips through sequential processing by the enzymes Drosha and Dicer. Dicer-generated miRNAs are incorporated into the RNA-induced silencing complex that mediates miRNA-dependent translational suppression or in some instances cleavage of respective mRNA targets or translational activation. The significance of miRNAs in cholesterol metabolism and their importance in atherosclerosis remain unclear. The main aim of this project include to elucidate the role of microRNAs in cholesterol metabolism using different cell lines (hepatocytes, monocyte/macrophage, fibroblast). 2. Study the cellular cholesterol trafficking and compartmentalization. Cholesterol is an essential structural component in the cell membranes of most vertebrates. The biophysical properties of cholesterol and the enzymology of cholesterol metabolism provide the basis for how cells handle cholesterol and exchange it with one another. A tightly controlled-but only partially characterized-network of cellular signalling and lipid transfer systems orchestrates the functional compartmentalization of this lipid within and between tissues at the whole body level. Increased understanding of these processes and their integration at the organ systems levels provides fundamental insights into the physiology of cholesterol trafficking. However several issues await further studies. For the most sterol transport processes, only a limited number of proteins that are involved have been identified and very little is known about cholesterol trafficking in many physiologically relevant cell types, such us hepatocytes, enterocytes or cells of the central nervous system. Future work will focus on determining the molecular mechanism involved in the cholesterol trafficking in mammalian cells using functional genomic screens. 3. Role of PI3K/Akt signalling pathway in atherosclerosis. In the cardiovascular system, Akt plays an important role in the regulation of cardiac hypertrophy, angiogenesis, and apoptosis. Very recently, I showed that genetic ablation of Akt1 on an apolipoprotein E knockout background (ApoE-/-Akt1-/-) increases aortic lesion expansion and promotes coronary atherosclerosis. The increased atherosclerosis observed was associated with increased cellular apoptosis, vascular inflammation and reduced eNOS phosphorylation. Based on these observations, I hypothesize that Akt1 is a critical kinase that is essential for the control of vascular homeostasis and atherogenesis. As a corollary of this hypothesis, I predict that modulating Akt1 activity will delay the development of atherosclerosis.

Grant Keywords

Metabolism, Lipid, Cholesterol, Lipoproteins, Arteriosclerosis/Atherosclerosis, Cardiovascular Diseases

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
Danielson, Laura S; Park, David S; Rotllan, Noemi; Chamorro-Jorganes, Aranzazu; Guijarro, Maria V; Fernandez-Hernando, Carlos; Fishman, Glenn I; Phoon, Colin K L; Hernando, Eva
2013 Apr;27(4):1460-1467, FASEB journal
— id: 271182, year: 2013, vol: 27, page: 1460, stat: Journal Article,

From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport
Davalos, Alberto; Fernandez-Hernando, Carlos
2013 Feb;:322-322, Pharmacological research
— id: 287562, year: 2013, vol: , page: 322, stat: Journal Article,

Emerging role of MicroRNAs in the regulation of lipid metabolism
Fernandez-Hernando, Carlos
2013 Feb;57(2):432-434, Hepatology
— id: 217732, year: 2013, vol: 57, page: 432, stat: Journal Article,

Lymphatic vessels clean up your arteries
Fernandez-Hernando, Carlos
2013 Apr;123(4):1417-1419, Journal of clinical investigation
— id: 287542, year: 2013, vol: 123, page: 1417, stat: Journal Article,

MicroRNAs in Metabolic Disease
Fernandez-Hernando, Carlos; Ramirez, Cristina M; Goedeke, Leigh; Suarez, Yajaira
2013 Feb;33(2):178-185, Arteriosclerosis, thrombosis, & vascular biology
— id: 221462, year: 2013, vol: 33, page: 178, stat: Journal Article,

A regulatory role for miRNA-33* in controlling lipid metabolism gene expression
Goedeke, Leigh; Vales-Lara, Frances M; Fenstermaker, Michael; Cirera-Salinas, Daniel; Chamorro-Jorganes, Aranzazu; Ramirez, Cristina M; Mattison, Julie A; de Cabo, Rafael; Suarez, Yajaira; Fernandez-Hernando, Carlos
2013 Apr;:2339-2352, Molecular & cellular biology
— id: 287532, year: 2013, vol: , page: 2339, stat: Journal Article,

MicroRNAs and Atherosclerosis
Madrigal-Matute, Julio; Rotllan, Noemi; Aranda, Juan F; Fernandez-Hernando, Carlos
2013 May;15(5):322-322, Current atherosclerosis reports
— id: 248322, year: 2013, vol: 15, page: 322, stat: Journal Article,

MicroRNAs and lipoproteins: A connection beyond atherosclerosis?
Norata, Giuseppe Danilo; Sala, Federica; Catapano, Alberico Luigi; Fernandez-Hernando, Carlos
2013 Apr;227(2):209-215, Atherosclerosis
— id: 287572, year: 2013, vol: 227, page: 209, stat: Journal Article,

Control of Cholesterol Metabolism and Plasma HDL Levels by miRNA-144
Ramirez, Cristina M; Rotllan, Noemi; Vlassov, Alexander V; Davalos, Alberto; Li, Mu; Goedeke, Leigh; Aranda, Juan F; Cirera-Salinas, Daniel; Araldi, Elisa; Salerno, Alessandro; Wanschel, Amarylis Claudine Bonito Azeredo; Zavadil, Jiri; Castrillo, Antonio; Jungsu, Kim; Suarez, Yajaira; Fernandez-Hernando, Carlos
2013 Mar;:1417-1419, Circulation research
— id: 287552, year: 2013, vol: , page: 1417, stat: Journal Article,

Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats
Ribera, Jordi; Pauta, Montse; Melgar-Lesmes, Pedro; Tugues, Sonia; Fernandez-Varo, Guillermo; Held, Kara F; Soria, Guadalupe; Tudela, Raul; Planas, Anna M; Fernandez-Hernando, Carlos; Arroyo, Vicente; Jimenez, Wladimiro; Morales-Ruiz, Manuel
2013 Jan;62(1):138-145, Gut: journal of the British Society of Gastroenterology
— id: 210182, year: 2013, vol: 62, page: 138, stat: Journal Article,

Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits through Disruption of a MicroRNA-410 Seed Site
Richardson, Kris; Nettleton, Jennifer A; Rotllan, Noemi; Tanaka, Toshiko; Smith, Caren E; Lai, Chao-Qiang; Parnell, Laurence D; Lee, Yu-Chi; Lahti, Jari; Lemaitre, Rozenn N; Manichaikul, Ani; Keller, Margaux; Mikkila, Vera; Ngwa, Julius; van Rooij, Frank J A; Ballentyne, Christie M; Borecki, Ingrid B; Cupples, L Adrienne; Garcia, Melissa; Hofman, Albert; Ferrucci, Luigi; Mozaffarian, Dariush; Perala, Mia-Maria; Raitakari, Olli; Tracy, Russell P; Arnett, Donna K; Bandinelli, Stefania; Boerwinkle, Eric; Eriksson, Johan G; Franco, Oscar H; Kahonen, Mika; Nalls, Michael; Siscovick, David S; Houston, Denise K; Psaty, Bruce M; Viikari, Jorma; Witteman, Jacqueline C M; Goodarzi, Mark O; Lehtimaki, Terho; Liu, Yongmei; Zillikens, M Carola; Chen, Yii-Der I; Uitterlinden, Andre G; Rotter, Jerome I; Fernandez-Hernando, Carlos; Ordovas, Jose M
2013 Jan;92(1):5-14, American journal of human genetics
— id: 217322, year: 2013, vol: 92, page: 5, stat: Journal Article,

Proanthocyanidins modulate miR-33a and its target gene ATP-binding cassette transporter A1 in HepG2 cells
Baselga-Escudero, L.; Ramirez, C. M.; Fernandez-Hernando, A.; Vales-Lara, F. M.; Blade, C.; Arola-Arnal, A.; Fernandez-Hernando, C.
2012 SEP;279 1 1(SI):399-399, FEBS journal
— id: 178297, year: 2012, vol: 279 1 1, page: 399, stat: Journal Article,

Mir-33 regulates cell proliferation and cell cycle progression
Cirera-Salinas, D; Pauta, M; Allen, RM; Salerno, AG; Ramirez, CM; Chamorro-Jorganes, A; Wanschel, AC; Lasuncion, MA; Morales-Ruiz, M; Suarez, Y; Baldan, A; Esplugues, E; Fernandez-Hernando, C
2012 Mar;11(5):922-933, Cell cycle
— id: 163698, year: 2012, vol: 11, page: 922, stat: Journal Article,

Regulation of cholesterol homeostasis
Goedeke, Leigh; Fernandez-Hernando, Carlos
2012 Mar;69(6):915-930, Cellular & molecular life sciences: CMLS
— id: 158263, year: 2012, vol: 69, page: 915, stat: Journal Article,

miR-106b impairs cholesterol efflux and increases Abeta levels by repressing ABCA1 expression
Kim, Jaekwang; Yoon, Hyejin; Ramirez, Cristina M; Lee, Sang-Mi; Hoe, Hyang-Sook; Fernandez-Hernando, Carlos; Kim, Jungsu
2012 Jun;235(2):476-483, Experimental neurology
— id: 166966, year: 2012, vol: 235, page: 476, stat: Journal Article,

MicroRNAs regulating lipid metabolism in atherogenesis
Rayner, K J; Fernandez-Hernando, C; Moore, K J
2012 Apr;107(4):642-647, Thrombosis & haemostasis
— id: 166813, year: 2012, vol: 107, page: 642, stat: Journal Article,

MicroRNA Regulation of Cholesterol Metabolism
Rotllan, Noemi; Fernandez-Hernando, Carlos
2012 ;2012:847849-847849, Cholesterol
— id: 177030, year: 2012, vol: 2012, page: 847849, stat: Journal Article,

New insights into microRNA-29 regulation: a new key player in cardiovascular disease
Suarez, Yajaira; Fernandez-Hernando, Carlos
2012 Mar;52(3):584-586, Journal of molecular & cellular cardiology
— id: 164275, year: 2012, vol: 52, page: 584, stat: Journal Article,

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function
Albinsson, Sebastian; Skoura, Athanasia; Yu, Jun; DiLorenzo, Annarita; Fernandez-Hernando, Carlos; Offermanns, Stefan; Miano, Joseph M; Sessa, William C
2011 ;6(4):e18869-e18869 e18869, PLoS ONE
— id: 287582, year: 2011, vol: 6, page: e18869, stat: Journal Article,

Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122
Boutz, Daniel R; Collins, Patrick J; Suresh, Uthra; Lu, Mingzhu; Ramirez, Cristina M; Fernandez-Hernando, Carlos; Huang, Yufei; de Sousa Abreu, Raquel; Le, Shu-Yun; Shapiro, Bruce A; Liu, Angela M; Luk, John M; Force Aldred, Shelley; Trinklein, Nathan D; Marcotte, Edward M; Penalva, Luiz O F
2011 May 20;286(20):18066-18078, Journal of biological chemistry
— id: 134201, year: 2011, vol: 286, page: 18066, stat: Journal Article,

MicroRNA-16 and MicroRNA-424 Regulate Cell-Autonomous Angiogenic Functions in Endothelial Cells via Targeting Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1
Chamorro-Jorganes, Aranzazu; Araldi, Elisa; Penalva, Luiz O F; Sandhu, Devraj; Fernandez-Hernando, Carlos; Suarez, Yajaira
2011 Nov;31(11):2595-2606, Arteriosclerosis, thrombosis, & vascular biology
— id: 139472, year: 2011, vol: 31, page: 2595, stat: Journal Article,

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Davalos, Alberto; Goedeke, Leigh; Smibert, Peter; Ramirez, Cristina M; Warrier, Nikhil P; Andreo, Ursula; Cirera-Salinas, Daniel; Rayner, Katey; Suresh, Uthra; Pastor-Pareja, Jose Carlos; Esplugues, Enric; Fisher, Edward A; Penalva, Luiz O F; Moore, Kathryn J; Suarez, Yajaira; Lai, Eric C; Fernandez-Hernando, Carlos
2011 May 31;108(22):9232-9237, Proceedings of the National Academy of Sciences of the United States of America
— id: 133351, year: 2011, vol: 108, page: 9232, stat: Journal Article,

Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages
Feig, Jonathan E; Shang, Yueting; Rotllan, Noemi; Vengrenyuk, Yuliya; Wu, Chaowei; Shamir, Raanan; Torra, Ines Pineda; Fernandez-Hernando, Carlos; Fisher, Edward A; Garabedian, Michael J
2011 ;6(12):e28534-e28534, PLoS ONE
— id: 146266, year: 2011, vol: 6, page: e28534, stat: Journal Article,

MicroRNA Modulation of Cholesterol Homeostasis
Fernandez-Hernando, Carlos; Moore, Kathryn J
2011 Nov;31(11):2378-2382, Arteriosclerosis, thrombosis, & vascular biology
— id: 139482, year: 2011, vol: 31, page: 2378, stat: Journal Article,

MicroRNAs in lipid metabolism
Fernandez-Hernando, Carlos; Suarez, Yajaira; Rayner, Katey J; Moore, Kathryn J
2011 Apr;22(2):86-92, Current opinion in lipidology
— id: 128788, year: 2011, vol: 22, page: 86, stat: Journal Article,

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira; Fernandez-Hernando, Carlos
2011 Aug 21;31:49-63, Annual review of nutrition
— id: 138339, year: 2011, vol: 31, page: 49, stat: Journal Article,

MicroRNA-758 Regulates Cholesterol Efflux Through Posttranscriptional Repression of ATP-Binding Cassette Transporter A1
Ramirez, Cristina M; Davalos, Alberto; Goedeke, Leigh; Salerno, Alessandro G; Warrier, Nikhil; Cirera-Salinas, Daniel; Suarez, Yajaira; Fernandez-Hernando, Carlos
2011 Nov;31(11):2707-2714, Arteriosclerosis, thrombosis, & vascular biology
— id: 139473, year: 2011, vol: 31, page: 2707, stat: Journal Article,

"Micromanaging" metabolic syndrome
Ramirez, Cristina M; Goedeke, Leigh; Fernandez-Hernando, Carlos
2011 Oct 1;10(19):3249-3252, Cell cycle
— id: 139919, year: 2011, vol: 10, page: 3249, stat: Journal Article,

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, Katey J; Esau, Christine C; Hussain, Farah N; McDaniel, Allison L; Marshall, Stephanie M; van Gils, Janine M; Ray, Tathagat D; Sheedy, Frederick J; Goedeke, Leigh; Liu, Xueqing; Khatsenko, Oleg G; Kaimal, Vivek; Lees, Cynthia J; Fernandez-Hernando, Carlos; Fisher, Edward A; Temel, Ryan E; Moore, Kathryn J
2011 Oct 20;478(7369):404-407, Nature
— id: 139483, year: 2011, vol: 478, page: 404, stat: Journal Article,

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
Rayner, Katey J; Sheedy, Frederick J; Esau, Christine C; Hussain, Farah N; Temel, Ryan E; Parathath, Saj; van Gils, Janine M; Rayner, Alistair J; Chang, Aaron N; Suarez, Yajaira; Fernandez-Hernando, Carlos; Fisher, Edward A; Moore, Kathryn J
2011 Jul 1;121(7):2921-2931, Journal of clinical investigation
— id: 136939, year: 2011, vol: 121, page: 2921, stat: Journal Article,

The PLIN4 Variant rs8887 Modulates Obesity Related Phenotypes in Humans through Creation of a Novel miR-522 Seed Site
Richardson, Kris; Louie-Gao, Qiong; Arnett, Donna K; Parnell, Laurence D; Lai, Chao-Qiang; Davalos, Alberto; Fox, Caroline S; Demissie, Serkalem; Cupples, L Adrienne; Fernandez-Hernando, Carlos; Ordovas, Jose M
2011 ;6(4):e17944-e17944, PLoS ONE
— id: 133425, year: 2011, vol: 6, page: e17944, stat: Journal Article,

Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells
Davalos, Alberto; Fernandez-Hernando, Carlos; Sowa, Grzegorz; Derakhshan, Behrad; Lin, Michelle I; Lee, Ji Y; Zhao, Hongyu; Luo, Ruiyan; Colangelo, Christopher; Sessa, William C
2010 Oct;9(10):2109-2124, Molecular & cellular proteomics
— id: 287602, year: 2010, vol: 9, page: 2109, stat: Journal Article,

Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice
Fernandez-Hernando, Carlos; Yu, Jun; Davalos, Alberto; Prendergast, Jay; Sessa, William C
2010 Aug;177(2):998-1003, American journal of pathology
— id: 133802, year: 2010, vol: 177, page: 998, stat: Journal Article,

microRNAs and cholesterol metabolism
Moore, Kathryn J; Rayner, Katey J; Suarez, Yajaira; Fernandez-Hernando, Carlos
2010 Dec;21(12):699-706, Trends in endocrinology & metabolism
— id: 138240, year: 2010, vol: 21, page: 699, stat: Journal Article,

Mir-33 Coordinates Genes Regulating Cholesterol Homeostasis
Rayner, Katey J.; Suarez, Yajaira; Davalos, Alberto; Parathath, Saj; Fitzgerald, Michael L.; Tamehiro, Norimasa; Fisher, Edward A.; Moore, Kathryn J.; Fernandez-Hernando, Carlos
2010 NOV ;30(11):E191-E191, Arteriosclerosis, thrombosis, & vascular biology
— id: 117305, year: 2010, vol: 30, page: E191, stat: Journal Article,

MiR-33 contributes to the regulation of cholesterol homeostasis
Rayner, Katey J; Suarez, Yajaira; Davalos, Alberto; Parathath, Saj; Fitzgerald, Michael L; Tamehiro, Norimasa; Fisher, Edward A; Moore, Kathryn J; Fernandez-Hernando, Carlos
2010 Jun 18;328(5985):1570-1573, Science
— id: 138135, year: 2010, vol: 328, page: 1570, stat: Journal Article,

Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells
Sanchez-Wandelmer, J; Davalos, A; de la Pena, G; Cano, S; Giera, M; Canfran-Duque, A; Bracher, F; Martin-Hidalgo, A; Fernandez-Hernando, C; Lasuncion, M A; Busto, R
2010 Apr;167(1):143-153, Neuroscience
— id: 287612, year: 2010, vol: 167, page: 143, stat: Journal Article,

ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase
Terasaka, Naoki; Westerterp, Marit; Koetsveld, Joris; Fernandez-Hernando, Carlos; Yvan-Charvet, Laurent; Wang, Nan; Sessa, William C; Tall, Alan R
2010 Nov;30(11):2219-2225, Arteriosclerosis, thrombosis, & vascular biology
— id: 287592, year: 2010, vol: 30, page: 2219, stat: Journal Article,

Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis
Chidlow, John H Jr; Greer, Joshua J M; Anthoni, Christoph; Bernatchez, Pascal; Fernandez-Hernando, Carlos; Bruce, Megan; Abdelbaqi, Maisoun; Shukla, Deepti; Granger, D Neil; Sessa, William C; Kevil, Christopher G
2009 Feb;136(2):575-84.e2, Gastroenterology
— id: 103229, year: 2009, vol: 136, page: 575, stat: Journal Article,

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage
Di Lorenzo, Annarita; Fernandez-Hernando, Carlos; Cirino, Giuseppe; Sessa, William C
2009 Aug 25;106(34):14552-14557, Proceedings of the National Academy of Sciences of the United States of America
— id: 103239, year: 2009, vol: 106, page: 14552, stat: Journal Article,

Absence of Akt1 Reduces Vascular Smooth Muscle Cell Migration and Survival and Induces Features of Plaque Vulnerability and Cardiac Dysfunction During Atherosclerosis
Fernandez-Hernando, Carlos; Jozsef, Levente; Jenkins, Deborah; Di Lorenzo, Annarita; Sessa, William C
2009 Dec;29(12):2033-2040, Arteriosclerosis, thrombosis, & vascular biology
— id: 103243, year: 2009, vol: 29, page: 2033, stat: Journal Article,

Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
Fernandez-Hernando, Carlos; Yu, Jun; Suarez, Yajaira; Rahner, Christoph; Davalos, Alberto; Lasuncion, Miguel A; Sessa, William C
2009 Jul;10(1):48-54, Cell metabolism
— id: 103238, year: 2009, vol: 10, page: 48, stat: Journal Article,

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking
Harrison, Kenneth D; Miao, Robert Qing; Fernandez-Hernando, Carlos; Suarez, Yajaira; Davalos, Alberto; Sessa, William C
2009 Sep;10(3):208-218, Cell metabolism
— id: 103241, year: 2009, vol: 10, page: 208, stat: Journal Article,

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line
Rodriguez-Acebes, Sara; de la Cueva, Paloma; Fernandez-Hernando, Carlos; Ferruelo, Antonio J; Lasuncion, Miguel A; Rawson, Robert B; Martinez-Botas, Javier; Gomez-Coronado, Diego
2009 Jun 1;420(2):305-315, Biochemical journal
— id: 103234, year: 2009, vol: 420, page: 305, stat: Journal Article,

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
Yu, Jun; Fernandez-Hernando, Carlos; Suarez, Yajaira; Schleicher, Michael; Hao, Zhengrong; Wright, Paulette L; DiLorenzo, Annarita; Kyriakides, Themis R; Sessa, William C
2009 Oct 13;106(41):17511-17516, Proceedings of the National Academy of Sciences of the United States of America
— id: 103244, year: 2009, vol: 106, page: 17511, stat: Journal Article,

Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation
Rodriguez-Acebes, Sara; de la Cueva, Paloma; Ferruelo, Antonio J; Fernandez-Hernando, Carlos; Lasuncion, Miguel A; Martinez-Botas, Javier; Gomez-Coronado, Diego
2008 Dec 12;377(2):484-488, Biochemical & biophysical research communications
— id: 103225, year: 2008, vol: 377, page: 484, stat: Journal Article,

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Schleicher, Michael; Shepherd, Benjamin R; Suarez, Yajaira; Fernandez-Hernando, Carlos; Yu, Jun; Pan, Yong; Acevedo, Lisette M; Shadel, Gerald S; Sessa, William C
2008 Jan 14;180(1):101-112, Journal of cell biology
— id: 103213, year: 2008, vol: 180, page: 101, stat: Journal Article,

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
Suarez, Yajaira; Fernandez-Hernando, Carlos; Yu, Jun; Gerber, Scott A; Harrison, Kenneth D; Pober, Jordan S; Iruela-Arispe, M Luisa; Merkenschlager, Matthias; Sessa, William C
2008 Sep 16;105(37):14082-14087, Proceedings of the National Academy of Sciences of the United States of America
— id: 103223, year: 2008, vol: 105, page: 14082, stat: Journal Article,

Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
Wang, Zhenglong; Liu, Bei; Wang, Ping; Dong, Xuemei; Fernandez-Hernando, Carlos; Li, Zhong; Hla, Timothy; Li, Zihai; Claffey, Kevin; Smith, Jonathan D; Wu, Dianqing
2008 Jan;118(1):195-204, Journal of clinical investigation
— id: 103212, year: 2008, vol: 118, page: 195, stat: Journal Article,

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function
Bernatchez, Pascal N; Acevedo, Lisette; Fernandez-Hernando, Carlos; Murata, Takahisa; Chalouni, Cecile; Kim, Jiae; Erdjument-Bromage, Hediye; Shah, Vijay; Gratton, Jean-Philippe; McNally, Elizabeth M; Tempst, Paul; Sessa, William C
2007 Oct 19;282(42):30745-30753, Journal of biological chemistry
— id: 103209, year: 2007, vol: 282, page: 30745, stat: Journal Article,

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease
Fernandez-Hernando, Carlos; Ackah, Eric; Yu, Jun; Suarez, Yajaira; Murata, Takahisa; Iwakiri, Yasuko; Prendergast, Jay; Miao, Robert Q; Birnbaum, Morris J; Sessa, William C
2007 Dec;6(6):446-457, Cell metabolism
— id: 103211, year: 2007, vol: 6, page: 446, stat: Journal Article,

Cholesterol starvation induces differentiation of human leukemia HL-60 cells
Sanchez-Martin, Carolina C; Davalos, Alberto; Martin-Sanchez, Covadonga; de la Pena, Gema; Fernandez-Hernando, Carlos; Lasuncion, Miguel A
2007 Apr 1;67(7):3379-3386, Cancer research
— id: 103203, year: 2007, vol: 67, page: 3379, stat: Journal Article,

Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells
Suarez, Yajaira; Fernandez-Hernando, Carlos; Pober, Jordan S; Sessa, William C
2007 Apr 27;100(8):1164-1173, Circulation research
— id: 103202, year: 2007, vol: 100, page: 1164, stat: Journal Article,

Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro
Davalos, Alberto; Fernandez-Hernando, Carlos; Cerrato, Francisca; Martinez-Botas, Javier; Gomez-Coronado, Diego; Gomez-Cordoves, Carmen; Lasuncion, Miguel A
2006 Jul;136(7):1766-1773, Journal of nutrition
— id: 103193, year: 2006, vol: 136, page: 1766, stat: Journal Article,

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
Fernandez-Hernando, Carlos; Fukata, Masaki; Bernatchez, Pascal N; Fukata, Yuko; Lin, Michelle I; Bredt, David S; Sessa, William C
2006 Jul 31;174(3):369-377, Journal of cell biology
— id: 103195, year: 2006, vol: 174, page: 369, stat: Journal Article,

Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression
Fernandez, Carlos; Martin, Miguel; Gomez-Coronado, Diego; Lasuncion, Miguel A
2005 May;46(5):920-929, Journal of lipid research
— id: 104335, year: 2005, vol: 46, page: 920, stat: Journal Article,

Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation
Fernandez-Hernando, Carlos; Suarez, Yajaira; Lasuncion, Miguel A
2005 Aug;29(4):591-602, Molecular & cellular neurosciences
— id: 103186, year: 2005, vol: 29, page: 591, stat: Journal Article,

Sterol stringency of proliferation and cell cycle progression in human cells
Suarez, Yajaira; Fernandez, Carlos; Ledo, Beatriz; Martin, Miguel; Gomez-Coronado, Diego; Lasuncion, Miguel A
2005 May 15;1734(2):203-213, Biochimica & biophysica acta
— id: 103953, year: 2005, vol: 1734, page: 203, stat: Journal Article,

Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation
Fernandez, Carlos; Lobo Md, Maria del Val T; Gomez-Coronado, Diego; Lasuncion, Miguel A
2004 Oct 15;300(1):109-120, Experimental cell research
— id: 104340, year: 2004, vol: 300, page: 109, stat: Journal Article,

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study
Ruiz-Llorente, Lidia; Ortega-Gutierrez, Silvia; Viso, Alma; Sanchez, Maria G; Sanchez, Ana M; Fernandez, Carlos; Ramos, Jose A; Hillard, Cecilia; Lasuncion, Miguel A; Lopez-Rodriguez, Maria L; Diaz-Laviada, Ines
2004 Feb;141(3):457-467, British journal of pharmacology
— id: 104341, year: 2004, vol: 141, page: 457, stat: Journal Article,

Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin
Suarez, Yajaira; Fernandez, Carlos; Gomez-Coronado, Diego; Ferruelo, Antonio J; Davalos, Alberto; Martinez-Botas, Javier; Lasuncion, Miguel A
2004 Nov 1;64(2):346-355, Cardiovascular research
— id: 103932, year: 2004, vol: 64, page: 346, stat: Journal Article,

Efecto de los fitosteroles sobre la biosintesis de colesterol y la proliferacion en celulas humanas
Fernandez C; Martin M; Gomez-Coronado D; Lasuncion MA
2003 ;15(5):175-183, Clinica e investigacion en arteriosclerosis
— id: 104343, year: 2003, vol: 15, page: 175, stat: Journal Article,

Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells
Fernandez, Carlos; Suarez, Yajaira; Ferruelo, Antonio J; Gomez-Coronado, Diego; Lasuncion, Miguel A
2002 Aug 15;366(Pt 1):109-119, Biochemical journal
— id: 103883, year: 2002, vol: 366, page: 109, stat: Journal Article,

Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription
Suarez, Yajaira; Fernandez, Carlos; Ledo, Beatriz; Ferruelo, Antonio J; Martin, Miguel; Vega, Miguel A; Gomez-Coronado, Diego; Lasuncion, Miguel A
2002 Mar;269(6):1761-1771, European journal of biochemistry
— id: 103870, year: 2002, vol: 269, page: 1761, stat: Journal Article,

Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives
Martinez-Botas, J; Ferruelo, A J; Suarez, Y; Fernandez, C; Gomez-Coronado, D; Lasuncion, M A
2001 Jun 29;1532(3):185-194, Biochimica & biophysica acta
— id: 104342, year: 2001, vol: 1532, page: 185, stat: Journal Article,