Biosketch / Results /

Joel Ernst

Jeffrey Bergstein Professor of Medicine, Department of Medicine;Professor, Department of Microbiology;Professor, Department of Pathology
Medicine

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-9410


Research Summary

The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.

Research Interests

Innate and adaptive immunity to intracellular bacteria; immunity to tuberculosis; whole genome sequencing

STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection
Desvignes, Ludovic; Weidinger, Carl; Shaw, Patrick; Vaeth, Martin; Ribierre, Theo; Liu, Menghan; Fergus, Tawania; Kozhaya, Lina; McVoy, Lauren; Unutmaz, Derya; Ernst, Joel D; Feske, Stefan
2015-05-11; 1558-8238,Journal of clinical investigation - id: 1569062, year: 2015 JOURNAL ARTICLE

Impaired M. tuberculosis Antigen-Specific IFN-gamma Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis
Fan, Lin; Xiao, Heping; Mai, Guangliang; Su, Bo; Ernst, Joel; Hu, Zhongyi
2015-06-08; 1932-6203,PLoS one - id: 1616452, year: 2015 Journal Article

In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection
Young, David C; Layre, Emilie; Pan, Shih-Jung; Tapley, Asa; Adamson, John; Seshadri, Chetan; Wu, Zhongtao; Buter, Jeffrey; Minnaard, Adriaan J; Coscolla, Mireia; Gagneux, Sebastien; Copin, Richard; Ernst, Joel D; Bishai, William R; Snider, Barry B; Moody, D Branch
2015-04-26; 1879-1301,Chemistry & biology - id: 1543712, year: 2015 JOURNAL ARTICLE

Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)
Copin, Richard; Coscolla, Mireia; Efstathiadis, Efstratios; Gagneux, Sebastien; Ernst, Joel D
2014-10-01; 0264-410x,Vaccine - id: 1258342, year: 2014 Journal Article

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition
Copin, Richard; Coscolla, Mireia; Seiffert, Salome N; Bothamley, Graham; Sutherland, Jayne; Mbayo, Georgetta; Gagneux, Sebastien; Ernst, Joel D
2014-04-24; 2150-7511,MBio - id: 900642, year: 2014 Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't