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Joel D Ernst, M.D.

Professor;
Departments of Pathology (Pathology), Medicine (ID&Immun Div) and Microbiology (Microbiology )

Clinical Addresses

SMILOW RESEARCH BLDG,
522 FIRST AVENUE, RM 901B
NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-9410

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Medical Specialties

Infectious Diseases

Clinical Infectious Diseases;

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Board Certification

1999 — Ab Internal Medicine (Infectious Disease)

Education

1974-1978 — University of Nebraska College of Medicine, Medical Education
1978-1979 — University of California - San Francisco (Medicine (Internal)), Internship
1978-1979 — University of California - San Francisco (Internal Medicine), Internship
1981-1982 — University of California - San Francisco (Infectious Diseases), Clinical Fellowships
1982-1984 — University of California - San Francisco (Hematology & Onc.), Clinical Fellowships

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Research Summary

The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.

Research Interests

Innate and adaptive immunity to intracellular bacteria; immunity to tuberculosis; whole genome sequencing

Research Keywords

tuberculosis; dendritic cells; innate immunity; MHC class II; bacterial genome sequencing