Biosketch / Results /

Joel D Ernst, M.D.

Departments of Pathology (Pathology), Medicine (ID&Immun Div) and Microbiology (Microbiology )

Clinical Addresses

NEW YORK, NY 10016
Handicap Access: yes
Phone: 212-263-9410

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Medical Specialties

Infectious Diseases

Clinical Infectious Diseases;

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Board Certification

1999 — Ab Internal Medicine (Infectious Disease)


1974-1978 — University of Nebraska College of Medicine, Medical Education
1978-1979 — University of California - San Francisco (Medicine (Internal)), Internship
1978-1979 — University of California - San Francisco (Internal Medicine), Internship
1981-1982 — University of California - San Francisco (Infectious Diseases), Clinical Fellowships
1982-1984 — University of California - San Francisco (Hematology & Onc.), Clinical Fellowships

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All data from NYU Health Sciences Library Faculty Bibliography — -


Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)
Copin, Richard; Coscolla, Mireia; Efstathiadis, Efstratios; Gagneux, Sebastien; Ernst, Joel D
2014 Oct;32(45):5998-6004, Vaccine
— id: 1258342, year: 2014, vol: 32, page: 5998, stat: Journal Article,

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition
Copin, Richard; Coscolla, Mireia; Seiffert, Salome N; Bothamley, Graham; Sutherland, Jayne; Mbayo, Georgetta; Gagneux, Sebastien; Ernst, Joel D
2014 ;5(1):e00960-e00913, MBio
— id: 900642, year: 2014, vol: 5, page: e00960, stat: Journal Article,

LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis
Gaur, Rajiv L; Ren, Kangning; Blumenthal, Antje; Bhamidi, Suresh; Gibbs, Sara; Jackson, Mary; Zare, Richard N; Ehrt, Sabine; Ernst, Joel D; Banaei, Niaz
2014 Sep;10(9):e1004376-e1004376 e1004376, PLoS pathogens
— id: 1252372, year: 2014, vol: 10, page: e1004376, stat: Journal Article,

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming
Srivastava, Smita; Ernst, Joel D
2014 Jun;15(6):741-752, Cell host & microbe
— id: 1033822, year: 2014, vol: 15, page: 741, stat: Journal Article,

Beyond macrophages: the diversity of mononuclear cells in tuberculosis
Srivastava, Smita; Ernst, Joel D; Desvignes, Ludovic
2014 Nov;262(1):179-192, Immunological reviews
— id: 1310232, year: 2014, vol: 262, page: 179, stat: Journal Article,

Induction of neural guidance molecule expression in macrophages and dendritic cells by Mycobacterium tuberculosis
Bracho-Sanchez, Edith; Ramkhelawon, Bhama; Desvignes, Ludovic; Moore, Kathryn; Ernst, Joel
2013 MAY 1;190:-, Journal of immunology (1950)
— id: 540702, year: 2013, vol: 190, page: , stat: Journal Article,

PE-PGRS genetic diversity in mycobacterium tuberculosis is not related to immune escape
Coscolla, M; Copin, R; Seiffert, S; Birrer, S; Davis, D; Ernst, J; Gagneux, S
2013 15 May 2013;4(4):338-339, Virulence
— id: 452892, year: 2013, vol: 4, page: 338, stat: Journal Article,

PE_PGRS Genetic Diversity in Mycobacterium tuberculosis Is Not Related to Immune Escape
Coscolla, M; Copin, R; Seiffert, S; Birrer, S; Davis, D; Ernst, J; Gagneux, S
2013 15 May 2013;Chakravortty(DDepartment):-, Virulence
— id: 782222, year: 2013, vol: Chakravortty, page: , stat: Journal Article,

Taking sides: interferons in leprosy
Desvignes, Ludovic P; Ernst, Joel D
2013 Apr;13(4):377-378, Cell host & microbe
— id: 304952, year: 2013, vol: 13, page: 377, stat: Journal Article,

Cutting Edge: Direct Recognition of Infected Cells by CD4 T Cells Is Required for Control of Intracellular Mycobacterium tuberculosis In Vivo
Srivastava, Smita; Ernst, Joel D
2013 Aug;191(3):1016-1020, Journal of immunology (1950)
— id: 458682, year: 2013, vol: 191, page: 1016, stat: Journal Article,

Equivalent T cell epitope promiscuity in ecologically diverse human pathogens
Wiens, Kirsten E; Swaminathan, Harish; Copin, Richard; Lun, Desmond S; Ernst, Joel D
2013 ;8(8):e73124-e73124 e73124, PLoS one
— id: 503592, year: 2013, vol: 8, page: e73124, stat: Journal Article,

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells
Blomgran, Robert; Desvignes, Ludovic; Briken, Volker; Ernst, Joel D
2012 Jan 19;11(1):81-90, Cell host & microbe
— id: 150571, year: 2012, vol: 11, page: 81, stat: Journal Article,

Impaired Fitness of Mycobacterium africanum Despite Secretion of ESAT-6
Bold, Tyler D; Davis, Daphne C; Penberthy, Kristen K; Cox, Laura M; Ernst, Joel D; de Jong, Bouke C
2012 Mar;205(6):984-990, Journal of infectious diseases
— id: 160239, year: 2012, vol: 205, page: 984, stat: Journal Article,

CD4+ T Cell-Dependent IFN-gamma Production by CD8+ Effector T Cells in Mycobacterium tuberculosis Infection
Bold, Tyler D; Ernst, Joel D
2012 Sep;189(5):2530-2536, Journal of immunology (1950)
— id: 175784, year: 2012, vol: 189, page: 2530, stat: Journal Article,

Dynamic Roles of Type I and Type II IFNs in Early Infection with Mycobacterium tuberculosis
Desvignes, Ludovic; Wolf, Andrea J; Ernst, Joel D
2012 Jun;188(12):6205-6215, Journal of immunology (1950)
— id: 169247, year: 2012, vol: 188, page: 6205, stat: Journal Article,

The immunological life cycle of tuberculosis
Ernst, Joel D
2012 ;12(8):581-591, Nature reviews. Immunology
— id: 174078, year: 2012, vol: 12, page: 581, stat: Journal Article,

Meeting report: The international conference on human immunity to tuberculosis
Ernst, Joel D; Hanekom, Willem; Hawn, Tom; Kampmann, Beate; Rengarajan, Jyothi
2012 Sep;92(5):440-444, Tuberculosis (Edinburgh, Scotland)
— id: 177020, year: 2012, vol: 92, page: 440, stat: Journal Article,

Variation of Mycobacterium tuberculosis Antigen-Specific IFN-gamma and IL-17 Responses in Healthy Tuberculin Skin Test (TST)-Positive Human Subjects
Fan, Lin; Xiao, He-Ping; Hu, Zhong-Yi; Ernst, Joel D
2012 ;7(8):e42716-e42716 e42716, PLoS one
— id: 174405, year: 2012, vol: 7, page: e42716, stat: Journal Article,

Tuberculosis Pathogenesis and Immunity
Philips JA; Ernst JD
2012 Feb;7:353-384, Annual review of pathology
— id: 145546, year: 2012, vol: 7, page: 353, stat: Journal Article,

Lung Neutrophils Facilitate Activation of Naive Antigen-Specific CD4+ T Cells during Mycobacterium tuberculosis Infection
Blomgran, Robert; Ernst, Joel D
2011 Jun 15;186(12):7110-7119, Journal of immunology (1950)
— id: 134309, year: 2011, vol: 186, page: 7110, stat: Journal Article,

Suboptimal Activation of Antigen-Specific CD4 Effector Cells Enables Persistence of M. tuberculosis In Vivo
Bold, Tyler D; Banaei, Niaz; Wolf, Andrea J; Ernst, Joel D
2011 May;7(5):e1002063-e1002063, PLoS pathogens
— id: 134314, year: 2011, vol: 7, page: e1002063, stat: Journal Article,

HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, Candice K; Ernst, Joel D
2011 Apr;24(2):351-376, Clinical microbiology reviews
— id: 130914, year: 2011, vol: 24, page: 351, stat: Journal Article,

Directly observing therapy: a new view of drug tolerance in tuberculosis
Philips, Jennifer A; Ernst, Joel D
2011 Apr 1;145(1):13-14, Cell
— id: 130308, year: 2011, vol: 145, page: 13, stat: Journal Article,

Initiation and regulation of T-cell responses in tuberculosis
Urdahl, K B; Shafiani, S; Ernst, J D
2011 May;4(3):288-293, Mucosal immunology
— id: 134238, year: 2011, vol: 4, page: 288, stat: Journal Article,

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
Comas, Inaki; Chakravartti, Jaidip; Small, Peter M; Galagan, James; Niemann, Stefan; Kremer, Kristin; Ernst, Joel D; Gagneux, Sebastien
2010 Jun;42(6):498-503, Nature genetics
— id: 145547, year: 2010, vol: 42, page: 498, stat: Journal Article,

Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice
Olmos, Sofia; Stukes, Sabriya; Ernst, Joel D
2010 Jan 15;184(2):895-901, Journal of immunology (1950)
— id: 106094, year: 2010, vol: 184, page: 895, stat: Journal Article,

Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green
Banaei, Niaz; Kincaid, Eleanor Z; Lin, S-Y Grace; Desmond, Edward; Jacobs, William R Jr; Ernst, Joel D
2009 Sep;53(9):3799-3802, Antimicrobial agents & chemotherapy
— id: 101954, year: 2009, vol: 53, page: 3799, stat: Journal Article,

TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms
Benson, Sarah A; Ernst, Joel D
2009 ;4(7):e6329-e6329, PLoS one
— id: 101286, year: 2009, vol: 4, page: e6329, stat: Journal Article,

RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
Blumenthal, Antje; Kobayashi, Toshihiko; Pierini, Lynda M; Banaei, Niaz; Ernst, Joel D; Miyake, Kensuke; Ehrt, Sabine
2009 Jan 22;5(1):35-46, Cell host & microbe
— id: 95568, year: 2009, vol: 5, page: 35, stat: Journal Article,

Who benefits from granulomas, mycobacteria or host?
Bold, Tyler D; Ernst, Joel D
2009 Jan 9;136(1):17-19, Cell
— id: 95569, year: 2009, vol: 136, page: 17, stat: Journal Article,

Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
Desvignes, Ludovic; Ernst, Joel D
2009 Dec 18;31(6):974-985, Immunity
— id: 106204, year: 2009, vol: 31, page: 974, stat: Journal Article,

Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed
Miller, Elizabeth A; Ernst, Joel D
2009 May;119(5):1079-1082, Journal of clinical investigation
— id: 98019, year: 2009, vol: 119, page: 1079, stat: Journal Article,

Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database
Ernst, Joel D; Lewinsohn, David M; Behar, Samuel; Blythe, Martin; Schlesinger, Larry S; Kornfeld, Hardy; Sette, Alessandro
2008 Jul;88(4):366-370, Tuberculosis (Edinburgh, Scotland)
— id: 75183, year: 2008, vol: 88, page: 366, stat: Journal Article,

Illuminating the black box of TNF action in tuberculous granulomas
Miller, Elizabeth A; Ernst, Joel D
2008 Aug;29(2):175-177, Immunity
— id: 93352, year: 2008, vol: 29, page: 175, stat: Journal Article,

CO-opting the host HO-1 pathway in tuberculosis and malaria
Sinnis, Photini; Ernst, Joel D
2008 May 15;3(5):277-279, Cell host & microbe
— id: 78798, year: 2008, vol: 3, page: 277, stat: Journal Article,

Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
Wolf, Andrea J; Desvignes, Ludovic; Linas, Beth; Banaiee, Niaz; Tamura, Toshiki; Takatsu, Kiyoshi; Ernst, Joel D
2008 Jan 21;205(1):105-115, Journal of experimental medicine
— id: 75722, year: 2008, vol: 205, page: 105, stat: Journal Article,

LspA-independent action of globomycin on Mycobacterium tuberculosis
Banaiee, Niaz; Jacobs, William R; Ernst, Joel D
2007 Aug;60(2):414-416, Journal of antimicrobial chemotherapy
— id: 73865, year: 2007, vol: 60, page: 414, stat: Journal Article,

An analysis of the epitope knowledge related to Mycobacteria
Blythe, Martin J; Zhang, Qing; Vaughan, Kerrie; de Castro, Romulo Jr; Salimi, Nima; Bui, Huynh-Hoa; Lewinsohn, David M; Ernst, Joel D; Peters, Bjoern; Sette, Alessandro
2007 ;3:10-10, Immunome research
— id: 78799, year: 2007, vol: 3, page: 10, stat: Journal Article,

Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
Ernst, Joel D; Trevejo-Nunez, Giraldina; Banaiee, Niaz
2007 Jul;117(7):1738-1745, Journal of clinical investigation
— id: 74160, year: 2007, vol: 117, page: 1738, stat: Journal Article,

Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo
Kincaid, Eleanor Z; Wolf, Andrea J; Desvignes, Ludovic; Mahapatra, Sebabrata; Crick, Dean C; Brennan, Patrick J; Pavelka, Martin S Jr; Ernst, Joel D
2007 Sep 1;179(5):3187-3195, Journal of immunology (1950)
— id: 75367, year: 2007, vol: 179, page: 3187, stat: Journal Article,

Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo
Wolf, Andrea J; Linas, Beth; Trevejo-Nunez, Giraldina J; Kincaid, Eleanor; Tamura, Toshiki; Takatsu, Kiyoshi; Ernst, Joel D
2007 Aug 15;179(4):2509-2519, Journal of immunology (1950)
— id: 74168, year: 2007, vol: 179, page: 2509, stat: Journal Article,

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages
Banaiee, N; Jacobs, W R Jr; Ernst, J D
2006 Nov;74(11):6449-6457, Infection & immunity
— id: 69586, year: 2006, vol: 74, page: 6449, stat: Journal Article,

Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2
Banaiee, Niaz; Kincaid, Eleanor Z; Buchwald, Ulrike; Jacobs, William R Jr; Ernst, Joel D
2006 Mar 1;176(5):3019-3027, Journal of immunology (1950)
— id: 64137, year: 2006, vol: 176, page: 3019, stat: Journal Article,

Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
Fortune, Sarah M; Solache, Alejandra; Jaeger, Alejandra; Hill, Preston J; Belisle, John T; Bloom, Barry R; Rubin, Eric J; Ernst, Joel D
2004 May 15;172(10):6272-6280, Journal of immunology (1950)
— id: 42682, year: 2004, vol: 172, page: 6272, stat: Journal Article,

CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
Peters, Wendy; Cyster, Jason G; Mack, Matthias; Schlondorff, Detlef; Wolf, Andrea J; Ernst, Joel D; Charo, Israel F
2004 Jun 15;172(12):7647-7653, Journal of immunology (1950)
— id: 43012, year: 2004, vol: 172, page: 7647, stat: Journal Article,

GTP-dependent secretion from neutrophils is regulated by Cdk5
Rosales, Jesusa L; Ernst, Joel D; Hallows, Janice; Lee, Ki-Young
2004 Dec 24;279(52):53932-53936, Journal of biological chemistry
— id: 78800, year: 2004, vol: 279, page: 53932, stat: Journal Article,

Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function
Kincaid, Eleanor Z; Ernst, Joel D
2003 Aug 15;171(4):2042-2049, Journal of immunology (1950)
— id: 38096, year: 2003, vol: 171, page: 2042, stat: Journal Article,

Innate Inhibition of Adaptive Immunity: Mycobacterium tuberculosis-Induced IL-6 Inhibits Macrophage Responses to IFN-gamma
Nagabhushanam, Vijaya; Solache, Alejandra; Ting, Li-Min; Escaron, Claire J; Zhang, Jennifer Y; Ernst, Joel D
2003 Nov 1;171(9):4750-4757, Journal of immunology (1950)
— id: 38268, year: 2003, vol: 171, page: 4750, stat: Journal Article,

Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis
Peters, Wendy; Ernst, Joel D
2003 Feb;5(2):151-158, Microbes & infection
— id: 34826, year: 2003, vol: 5, page: 151, stat: Journal Article,

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis
Peters W; Scott HM; Chambers HF; Flynn JL; Charo IF; Ernst JD
2001 Jul 3;98(14):7958-7963, Proceedings of the National Academy of Sciences of the United States of America
— id: 33860, year: 2001, vol: 98, page: 7958, stat: Journal Article,

Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii
Sonda S; Ting LM; Novak S; Kim K; Maher JJ; Farese RV Jr; Ernst JD
2001 Sep 14;276(37):34434-34440, Journal of biological chemistry
— id: 33859, year: 2001, vol: 276, page: 34434, stat: Journal Article,

Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons
Diamond MS; Roberts TG; Edgil D; Lu B; Ernst J; Harris E
2000 Jun;74(11):4957-4966, Journal of virology
— id: 42258, year: 2000, vol: 74, page: 4957, stat: Journal Article,

Bacterial inhibition of phagocytosis
Ernst JD
2000 Oct;2(5):379-386, Cellular microbiology
— id: 33861, year: 2000, vol: 2, page: 379, stat: Journal Article,

Editorial response: variation in clinical and immune responses to bacille Calmette-Guerin--implications for an improved tuberculosis vaccine
Ernst JD
1999 Apr;28(4):791-793, Clinical infectious diseases
— id: 33865, year: 1999, vol: 28, page: 791, stat: Journal Article,

Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee
Ernst JD
1999 Nov;29(5):1295-1302, Clinical infectious diseases
— id: 33866, year: 1999, vol: 29, page: 1295, stat: Journal Article,

Center for Child and Family Health-North Carolina. What is it? And why?
Frothingham, T E; Epstein, M S; Amana, C; Amaya-Jackson, L; Ernst, J; Runyan, D K
1999 Mar-Apr;60(2):83-89, North Carolina medical journal
— id: 158220, year: 1999, vol: 60, page: 83, stat: Journal Article,

Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1
Ting LM; Kim AC; Cattamanchi A; Ernst JD
1999 Oct 1;163(7):3898-3906, Journal of immunology (1950)
— id: 33867, year: 1999, vol: 163, page: 3898, stat: Journal Article,

Macrophage receptors for Mycobacterium tuberculosis
Ernst JD
1998 Apr;66(4):1277-1281, Infection & immunity
— id: 33871, year: 1998, vol: 66, page: 1277, stat: Journal Article,

Rates of tuberculosis infection in healthcare workers providing services to HIV-infected populations. Terry Beirn Community Programs for Clinical Research on AIDS
Zahnow K; Matts JP; Hillman D; Finley E; Brown LS Jr; Torres RA; Ernst J; El-Sadr W; Perez G; Webster C; Barber B; Gordin FM
1998 Nov;19(11):829-835, Infection control & hospital epidemiology
— id: 7866, year: 1998, vol: 19, page: 829, stat: Journal Article,

Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome
Collins HL; Schaible UE; Ernst JD; Russell DG
1997 Jan;110 ( Pt 2)(Suppl 5):191-200, Journal of cell science
— id: 33874, year: 1997, vol: 110 ( Pt 2), page: 191, stat: Journal Article,

Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V
Kuypers FA; Lewis RA; Hua M; Schott MA; Discher D; Ernst JD; Lubin BH
1996 Feb 1;87(3):1179-1187, Blood
— id: 33878, year: 1996, vol: 87, page: 1179, stat: Journal Article,

The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages
Read RC; Zimmerli S; Broaddus C; Sanan DA; Stephens DS; Ernst JD
1996 Aug;64(8):3210-3217, Infection & immunity
— id: 33877, year: 1996, vol: 64, page: 3210, stat: Journal Article,

Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages
Zimmerli S; Edwards S; Ernst JD
1996 Dec;15(6):760-770, American journal of respiratory cell & molecular biology
— id: 33875, year: 1996, vol: 15, page: 760, stat: Journal Article,

Phagosome-lysosome fusion is a calcium-independent event in macrophages
Zimmerli S; Majeed M; Gustavsson M; Stendahl O; Sanan DA; Ernst JD
1996 Jan;132(1-2):49-61, Journal of cell biology
— id: 33879, year: 1996, vol: 132, page: 49, stat: Journal Article,