Biosketch / Results /

Joel Ernst

Jeffrey Bergstein Professor of Medicine, Department of Medicine;Professor, Department of Microbiology;Professor, Department of Pathology

Contact Info

522 First Avenue
New York, NY 10016



1978 — Univ of Nebraska, Medical Education
1981-1984 — University of California, San Francisco, Clinical Fellowships
1984-1986 — University of California, San Francisco, PostDoctoral Training

Research Summary

The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.

Research Interests

Innate and adaptive immunity to intracellular bacteria; immunity to tuberculosis; whole genome sequencing

In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection
Young, David C; Layre, Emilie; Pan, Shih-Jung; Tapley, Asa; Adamson, John; Seshadri, Chetan; Wu, Zhongtao; Buter, Jeffrey; Minnaard, Adriaan J; Coscolla, Mireia; Gagneux, Sebastien; Copin, Richard; Ernst, Joel D; Bishai, William R; Snider, Barry B; Moody, D Branch
2015-04-26; 1879-1301,Chemistry & biology - id: 1543712, year: 2015 JOURNAL ARTICLE

Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)
Copin, Richard; Coscolla, Mireia; Efstathiadis, Efstratios; Gagneux, Sebastien; Ernst, Joel D
2014-10-01; 0264-410x,Vaccine - id: 1258342, year: 2014 Journal Article

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition
Copin, Richard; Coscolla, Mireia; Seiffert, Salome N; Bothamley, Graham; Sutherland, Jayne; Mbayo, Georgetta; Gagneux, Sebastien; Ernst, Joel D
2014-04-24; 2150-7511,MBio - id: 900642, year: 2014 Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis
Gaur, Rajiv L; Ren, Kangning; Blumenthal, Antje; Bhamidi, Suresh; Gibbs, Sara; Jackson, Mary; Zare, Richard N; Ehrt, Sabine; Ernst, Joel D; Banaei, Niaz
2014-09-29; 1553-7366,PLoS pathogens - id: 1252372, year: 2014 Journal Article

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming
Srivastava, Smita; Ernst, Joel D
2014-06-14; 1931-3128,Cell host & microbe - id: 1033822, year: 2014 JOURNAL ARTICLE