Adrian I Erlebacher

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Adrian Erlebacher

Research Associate Professor, Department of Pathology
Co-Director, Pathobiology Graduate Training

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-8926
Adrian.Erlebacher@nyumc.org

Education

1999 — UCSF, Medical Education

Research Summary

My laboratory is interested in the cellular and molecular mechanisms that allow the fetus to escape rejection by the maternal immune system during pregnancy. We have been focusing on two non-mutually exclusive possibilities. The first possibility is that there is an attenuation of the afferent arm of the immune response with regards to the fetal allograft. This might involve altered dendritic cell behavior at the maternal/fetal interface leading to the defective priming of maternal T cells, or the tolerization of T cells by antigens directly released hematogenously from the conceptus. The second possibility is that there is a defect in the efferent arm of the immune response, namely that alloreactive maternal T cells are unable to home to the maternal/fetal interface or perform effector functions there despite their activation. It is likely that a deeper understanding of these issues will have implications for peripheral immune tolerance and autoimmunity, tumor immunology, leukocyte trafficking, and clinical disorders of pregnancy.

Research Interests

Immunobiology of Pregnancy

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
Blaisdell, Adam; Crequer, Amandine; Columbus, Devin; Daikoku, Takiko; Mittal, Khush; Dey, Sudhansu K; Erlebacher, Adrian. Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. Cancer cell. 2015 Dec 14;28(6):785-799 (1878102)

Epigenetics of decidual inflammation
Erlebacher, A; Clementi, C; Siewiera, J; Nancy, P. Epigenetics of decidual inflammation [Meeting Abstract]. American journal of reproductive immunology (1989). 2015 May 2015;73:16-16 (1951762)

Immune mechanisms at the maternal-fetal interface: perspectives and challenges
PrabhuDas, Mercy; Bonney, Elizabeth; Caron, Kathleen; Dey, Sudhansu; Erlebacher, Adrian; Fazleabas, Asgerally; Fisher, Susan; Golos, Thaddeus; Matzuk, Martin; McCune, Joseph M; Mor, Gil; Schulz, Laura; Soares, Michael; Spencer, Thomas; Strominger, Jack; Way, Sing Sing; Yoshinaga, Koji. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nature immunology. 2015 Apr ;16(4):328-334 (1522522)

Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression
Blaisdell, A; Daikoku, T; Tay, C S; Dey, S; Erlebacher, A. Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression [Meeting Abstract]. Journal of immunology (1950). 2014 01 May;192(1):?-? (1058302)

T cell behavior at the maternal-fetal interface
Nancy, Patrice; Erlebacher, Adrian. T cell behavior at the maternal-fetal interface. International journal of developmental biology. 2014 ;58(2-4):189-198 (1161362)