Adrian I Erlebacher

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Adrian I Erlebacher, M.D., Ph.D.

Associate Professor; Co-Director, Pathobiology Graduate Training
Department of Pathology (Pathology)

Contact Info

550 First Ave.
Floor 3rd Room Smilow 311
Smilow Research Building
New York, NY 10016


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1997 — UCSF, Graduate Education
1999 — UCSF, Medical Education

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Research Summary

My laboratory is interested in the cellular and molecular mechanisms that allow the fetus to escape rejection by the maternal immune system during pregnancy. We have been focusing on two non-mutually exclusive possibilities. The first possibility is that there is an attenuation of the afferent arm of the immune response with regards to the fetal allograft. This might involve altered dendritic cell behavior at the maternal/fetal interface leading to the defective priming of maternal T cells, or the tolerization of T cells by antigens directly released hematogenously from the conceptus. The second possibility is that there is a defect in the efferent arm of the immune response, namely that alloreactive maternal T cells are unable to home to the maternal/fetal interface or perform effector functions there despite their activation. It is likely that a deeper understanding of these issues will have implications for peripheral immune tolerance and autoimmunity, tumor immunology, leukocyte trafficking, and clinical disorders of pregnancy.

Research Interests

Immunobiology of Pregnancy

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All data from NYU Health Sciences Library Faculty Bibliography — -


Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression
Blaisdell, A; Daikoku, T; Tay, C S; Dey, S; Erlebacher, A
2014 01 May 2014;192(1):-, Journal of immunology (1950)
— id: 1058302, year: 2014, vol: 192, page: , stat: Journal Article,

T cell behavior at the maternal-fetal interface
Nancy, Patrice; Erlebacher, Adrian
2014 ;58(2-4):189-198, International journal of developmental biology
— id: 1161362, year: 2014, vol: 58, page: 189, stat: Journal Article,

Immunology of the maternal-fetal interface
Erlebacher, Adrian
2013 Mar;31:387-411, Annual review of immunology
— id: 255182, year: 2013, vol: 31, page: 387, stat: Journal Article,

Mechanisms of T cell tolerance towards the allogeneic fetus
Erlebacher, Adrian
2013 Jan;13(1):23-33, Nature reviews. Immunology
— id: 207362, year: 2013, vol: 13, page: 23, stat: Journal Article,

Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells
Tay, Chin-Siean; Tagliani, Elisa; Collins, Mary K; Erlebacher, Adrian
2013 ;8(12):e84064-e84064 e84064, PLoS one
— id: 741072, year: 2013, vol: 8, page: e84064, stat: Journal Article,

Cellular and molecular orchestration of premalignant inflammation
Blaisdell, A; Daikoku, T; Tay, C; Dey, S K; Erlebacher, A
2012 April 2012;5(2):179-180, Clinical & translational science
— id: 173068, year: 2012, vol: 5, page: 179, stat: Journal Article,

[Epigenetic repression of chemokine expression at the maternal-fetal interface as a mechanism of feto-maternal tolerance]
Nancy, Patrice; Erlebacher, Adrian
2012 Dec;28(12):1037-1039, M/S: medecine sciences
— id: 211472, year: 2012, vol: 28, page: 1037, stat: Journal Article,

Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface
Nancy, Patrice; Tagliani, Elisa; Tay, Chin-Siean; Asp, Patrik; Levy, David E; Erlebacher, Adrian
2012 Jun;336(6086):1317-1321, Science
— id: 169515, year: 2012, vol: 336, page: 1317, stat: Journal Article,

Fetal programming and environmental exposures: implications for prenatal care and preterm birth
Schug, Thaddeus T; Erlebacher, Adrian; Leibowitz, Sarah; Ma, Liang; Muglia, Louis J; Rando, Oliver J; Rogers, John M; Romero, Roberto; vom Saal, Frederick S; Wise, David L
2012 Dec;1276:37-46, Annals of the New York Academy of Sciences
— id: 221312, year: 2012, vol: 1276, page: 37, stat: Journal Article,

Strangers no more: Uterine NK cell recognition of the placenta in mice
Erlebacher, Adrian
2011 Mar 15;108(11):4267-4268, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 127236, year: 2011, vol: 108, page: 4267, stat: Journal Article,

miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis
Gaziel-Sovran, Avital; Segura, Miguel F; Di Micco, Raffaella; Collins, Mary K; Hanniford, Douglas; Vega-Saenz de Miera, Eleazar; Rakus, John F; Dankert, John F; Shang, Shulian; Kerbel, Robert S; Bhardwaj, Nina; Shao, Yongzhao; Darvishian, Farbod; Zavadil, Jiri; Erlebacher, Adrian; Mahal, Lara K; Osman, Iman; Hernando, Eva
2011 Jul 12;20(1):104-118, Cancer cell
— id: 135264, year: 2011, vol: 20, page: 104, stat: Journal Article,

Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells
McCloskey, Megan L; Curotto de Lafaille, Maria A; Carroll, Michael C; Erlebacher, Adrian
2011 Jan 17;208(1):135-148, Journal of experimental medicine
— id: 120649, year: 2011, vol: 208, page: 135, stat: Journal Article,

Dendritic cell function at the maternal-fetal interface
Tagliani, Elisa; Erlebacher, Adrian
2011 Sep;7(5):593-602, Expert review of clinical immunology
— id: 137080, year: 2011, vol: 7, page: 593, stat: Journal Article,

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1
Tagliani, Elisa; Shi, Chao; Nancy, Patrice; Tay, Chin-Siean; Pamer, Eric G; Erlebacher, Adrian
2011 Aug 29;208(9):1901-1916, Journal of experimental medicine
— id: 137002, year: 2011, vol: 208, page: 1901, stat: Journal Article,

Immune surveillance of the maternal/fetal interface: controversies and implications
Erlebacher, Adrian
2010 Jul;21(7):428-434, Trends in endocrinology & metabolism
— id: 110681, year: 2010, vol: 21, page: 428, stat: Journal Article,

Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice
Collins, Mary K; Tay, Chin-Siean; Erlebacher, Adrian
2009 Jul;119(7):2062-2073, Journal of clinical investigation
— id: 100612, year: 2009, vol: 119, page: 2062, stat: Journal Article,

Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus
Erlebacher, Adrian; Vencato, Daniela; Price, Kelly A; Zhang, Dorothy; Glimcher, Laurie H
2007 May;117(5):1399-1411, Journal of clinical investigation
— id: 72867, year: 2007, vol: 117, page: 1399, stat: Journal Article,

Trophoblast shedding and its immunological consequences
Erlebacher, A; Price, K; Zhang, D; Glimcher, LH
2006 APR 1 ;176(4):S230-S230, Journal of immunology (1950)
— id: 68845, year: 2006, vol: 176, page: S230, stat: Journal Article,

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
Red-Horse, Kristy; Rivera, Jose; Schanz, Andrea; Zhou, Yan; Winn, Virginia; Kapidzic, Mirhan; Maltepe, Emin; Okazaki, Kelly; Kochman, Ronit; Vo, Kim Chi; Giudice, Linda; Erlebacher, Adrian; McCune, Joseph M; Stoddart, Cheryl A; Fisher, Susan J
2006 Oct;116(10):2643-2652, Journal of clinical investigation
— id: 81164, year: 2006, vol: 116, page: 2643, stat: Journal Article,

Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells
Tayade, Chandrakant; Fang, Yuan; Black, Gordon P; V A, Paffaro Jr; Erlebacher, Adrian; Croy, B Anne
2005 Dec;78(6):1347-1355, Journal of leukocyte biology
— id: 59378, year: 2005, vol: 78, page: 1347, stat: Journal Article,

Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin
Erlebacher, Adrian; Price, Kelly A; Glimcher, Laurie H
2004 Nov 1;275(1):158-169, Developmental biology (Orlando)
— id: 59380, year: 2004, vol: 275, page: 158, stat: Journal Article,

Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system
Erlebacher, Adrian; Zhang, Dorothy; Parlow, Albert F; Glimcher, Laurie H
2004 Jul;114(1):39-48, Journal of clinical investigation
— id: 59381, year: 2004, vol: 114, page: 39, stat: Journal Article,

National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development
Thadani, Pushpa V; Strauss, Jerome F 3rd; Dey, Sudhansu K; Anderson, Virginia M; Audus, Kenneth L; Coats, Karen S; Cross, James C; Erlebacher, Adrian; Ganapathy, Vadivel; Linzer, Daniel I; Miller, Richard K; Novak, Donald A; Rapaka, Rao S; Sadovsky, Yoel; Salafia, Carolyn M; Soares, Michael; Unadkat, Jashvant
2004 Dec;191(6):1858-1862, American journal of obstetrics & gynecology
— id: 59379, year: 2004, vol: 191, page: 1858, stat: Journal Article,

Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo
Erlebacher, Adrian; Lukens, Amanda K; Glimcher, Laurie H
2002 Dec 24;99(26):16940-16945, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 59382, year: 2002, vol: 99, page: 16940, stat: Journal Article,

Why isn't the fetus rejected?
Erlebacher A
2001 Oct;13(5):590-593, Current opinion in immunology
— id: 61589, year: 2001, vol: 13, page: 590, stat: Journal Article,

Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass
Filvaroff E; Erlebacher A; Ye J; Gitelman SE; Lotz J; Heillman M; Derynck R
1999 Oct;126(19):4267-4279, Development
— id: 61590, year: 1999, vol: 126, page: 4267, stat: Journal Article,

Osteoblastic responses to TGF-beta during bone remodeling
Erlebacher A; Filvaroff EH; Ye JQ; Derynck R
1998 Jul;9(7):1903-1918, Molecular biology of the cell
— id: 61591, year: 1998, vol: 9, page: 1903, stat: Journal Article,

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
Erlebacher A; Derynck R
1996 Jan;132(1-2):195-210, Journal of cell biology
— id: 61592, year: 1996, vol: 132, page: 195, stat: Journal Article,

Toward a molecular understanding of skeletal development
Erlebacher A; Filvaroff EH; Gitelman SE; Derynck R
1995 Feb 10;80(3):371-378, Cell
— id: 61593, year: 1995, vol: 80, page: 371, stat: Journal Article,

Despite expression in embryonic visceral mesoderm, H2.0 is not essential for Drosophila visceral muscle morphogenesis
Barad M; Erlebacher A; McGinnis W
1991 ;12(3):206-211, Developmental genetics
— id: 61594, year: 1991, vol: 12, page: 206, stat: Journal Article,