Michael Engelbert

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Michael Engelbert, M.D., Ph.D.

Research Assistant Professor;
Department of Ophthalmology (Resident Train )

Contact Info


, AL

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Clinical Responsibilities

Michael Engelbert, M.D. Ph.D. is a vitreoretinal surgeon and macular disease specialist, with a special interest in age-related macular degeneration, diabetes and retinal detachment surgery, as well as sight-threatening infections of the eye. Dr. Engelbert received his medical degree Magna Cum Laude from Ludwig-Maximilians-University in Munich, Germany, after which he dedicated himself several years to basic research in the study of endophthalmitis, a vision-threatening infection, that can occur after eye surgery. He earned a Ph.D. for this work, and is considered a leader in this field. Dr. Engelbert is continuing this research at the Skirball Center for Molecular Pathogenesis at NYU in cooperation with Dr. Richard Novick, a member of the National Academy of Sciences. Before joining the residency program at Columbia University, Dr. Engelbert served his internship at Griffin Hospital, a Yale-affiliated center in Connecticut, where he was granted the Vincent D. DeLuca award for the best medical intern. Afterwards he was resident and chief resident in the Department of Ophthalmology of Columbia University?s College of Physicians and Surgeons at the Edward S. Harkness Eye Insitute on the Columbia Presbyterian Medical Center Campus. Following his residency training, Dr. Engelbert was awarded a medical and surgical vitreoretinal fellowship at Manhattan Eye Ear & Throat Hospital and Columbia University. Dr. Engelbert is a member of The American Society of Retina Specialists (ASRS), The European Society of Vitreoretinal Specialists (EVRS), the Association for Research in Vision and Ophthalmology (ARVO) and The American Academy of Ophthalmology (AAO). He has published numerous papers on retinal disease, received several awards and has been granted permanent resident status in the United States in the category ?outstanding scientist?. He serves as a reviewer for the premier journals in the field, including the Archives of Ophthalmology, Retina, Eye, and Graefe?s Archives of Clinical and Experimental Ophthalmology. He is a Research Assistant Professor at New York University and Clinical Instructor at NYU, where he is actively involved in instructing residents and fellows in the art of medical retina and retinal surgery.



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Board Certification

2011 — Ab Ophthalmology - Ophthalmology


1997-1999 — Ludwig Maximilians Universitat, Medical Education
— New York Eye and Ear Infirmary (Vitreoretinal Dis.), Clinical Fellowships
2004-2005 — Yale University School of Medicine (Internal Medicine), Internship
2005-2008 — Columbia University College of Physicians & Surgeons (Ophthalmology), Residency Training

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Research Summary

The incidence of endophthalmitis, a potentially blinding infection of the interior of the eye is becoming an ever more important public health problem, since intraocular procedures have experienced exponential growth in recent years. The molecular pathogenesis of endophthalmitis (and many other bacterial infections) is poorly understood, and potential therapeutic avenues therefore remain unexplored. S. aureus is the most important cause of severe endophthalmitis (and many other sever infections), with less than half of patients regaining vision better than 20/200, the cutoff for legal blindness. S. aureus will be the focus of the proposed research. The overarching goal of this project is to characterize the organisms causing severe ocular S. aureus infections, and use endophthalmitis as a model of disease that affords an unparalleled view of the mechanisms involved in the molecular pathogenesis of bacterial infection. The specific goals of this project are to (i) collect and characterize bacterial isolates from ocular infections in a collaborative fashion both locally, nationally and internationally, and characterize them on the molecular level, (ii) analyze the host-pathogen interactions that lead to an untoward outcome in S. aureus endophthalmitis by employing genetically modified bacterial strains and knockout host organisms in animal models developed by the principal investigator, and (iii) therapeutically modulate bacterial gene expression and the host response based on the knowledge gleaned from (i) and (ii) to improve visual outcome of patients with endophthalmitis, or other severe staphylococcal infections. The principal investigator has an established network of collaborators both on the NYU Campus (R.Novick Ph.D., B. Shopsin M.D.) and outside of NYU both in New York (R. Rosen M.D., NYEE; S.C. Chang M.D., Columbia University) and outside (M.S. Gilmore Ph.D., Harvard University; H. Flynn M.D., Bascom Palmer Eye Institute; H. Mi?o de Kaspar Ph.D., Stanford University and Munich University, Germany) that allows for collaborative collection of bacterial strains and to monitor emerging etiologic trends nationally and internationally.

Research Interests

bacterial endophthalmitis, molecular epidemiology and pathogenesis of Staphylococcus aureus infection

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All data from NYU Health Sciences Library Faculty Bibliography — -


Pars plana vitrectomy in patients with myopic macular retinoschisis
Chang, Jonathan S; Flynn, Harry W Jr; Engelbert, Michael; Shane, Anita R; Smiddy, William E; Chang, Stanley
2014 Apr;98(4):534-537, British journal of ophthalmology
— id: 905892, year: 2014, vol: 98, page: 534, stat: Journal Article,

Choroidal Neovascularization and Chorioretinal Anastomoses Following Laser Treatment of a Secondary Vasoproliferative Tumor
Chen, Christine Y; Engelbert, Michael; Freund, K Bailey; Shields, Carol L; Barile, Gaetano
2014 Sep;:?-? e106074, JAMA Ophthalmology
— id: 1181002, year: 2014, vol: , page: ?, stat: Journal Article,

Microbiological Spectrum and Antibiotic Sensitivity in Endophthalmitis: A 25-Year Review
Gentile, Ronald C; Shukla, Salil; Shah, Mahendra; Ritterband, David C; Engelbert, Michael; Davis, Andrew; Hu, Dan-Ning
2014 Apr;:534-537, Ophthalmology
— id: 905912, year: 2014, vol: , page: 534, stat: Journal Article,

Enhanced Vitreous Imaging Technique With Spectral-Domain Optical Coherence Tomography for Evaluation of Posterior Vitreous Detachment
Pang, Claudine E; Freund, K Bailey; Engelbert, Michael
2014 Jul;:1148-1150 e26314, JAMA Ophthalmology
— id: 1073572, year: 2014, vol: , page: 1148, stat: Journal Article,

Immunogammopathies and acquired vitelliform detachments: a report of four cases
Rusu, Irene M; Mrejen, Sarah; Engelbert, Michael; Gallego-Pinazo, Roberto; Ober, Michael D; Johnson, Mark W; Leys, Anita; Yannuzzi, Lawrence A
2014 Mar;157(3):648-657.e1, American journal of ophthalmology
— id: 810992, year: 2014, vol: 157, page: 648, stat: Journal Article,

The Premacular Bursa's Shape Revealed In Vivo by Swept-Source Optical Coherence Tomography
Schaal, Karen B; Pang, Claudine E; Pozzoni, M Carolina; Engelbert, Michael
2014 Feb;:534-537, Ophthalmology
— id: 905902, year: 2014, vol: , page: 534, stat: Journal Article,

Subretinal deposits, paramacular atrophy and pigmentary retinopathy in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes
Fung, Adrian T; Engelbert, Michael; Odel, Jeffrey G; Yannuzzi, Lawrence A
2013 Winter;7(1):14-18, Retinal cases & brief reports
— id: 1349102, year: 2013, vol: 7, page: 14, stat: Journal Article,

Idiopathic macular telangiectasia type 2: the progressive vasculopathy
Engelbert, Michael; Yannuzzi, Lawrence A
2012 Nov;:0-0, European journal of ophthalmology
— id: 543202, year: 2012, vol: , page: 0, stat: Journal Article,

POLYPOIDAL CHOROIDAL VASCULOPATHY: Simultaneous Indocyanine Green Angiography and Eye-Tracked Spectral Domain Optical Coherence Tomography Findings
Khan, Samira; Engelbert, Michael; Imamura, Yutaka; Freund, K Bailey
2012 Jun;32(6):1057-1068, Retina
— id: 167793, year: 2012, vol: 32, page: 1057, stat: Journal Article,

Peripapillary choroidal neovascularization in best disease
Pozzoni, Maria Carolina; Fine, Howard F; Ferrara, Daniela C; Klancnik, James M Jr; Engelbert, Michael; Yannuzzi, Lawrence A
2012 Spring;6(2):176-178, Retinal cases & brief reports
— id: 1349172, year: 2012, vol: 6, page: 176, stat: Journal Article,

Imaging in the diagnosis and management of acute macular neuroretinopathy
Yzer, Suzanne; Freund, Kenneth Bailey; Engelbert, Michael
2012 Fall;52(4):269-273, International ophthalmologic clinics
— id: 905882, year: 2012, vol: 52, page: 269, stat: Journal Article,

Spectral domain optical coherence tomography macular cube scans and retinal pigment epithelium/drusen maps may fail to display subretinal drusenoid deposits (reticular pseudodrusen) in eyes with non-neovascular age-related macular degeneration
Switzer, D W; Engelbert, M; Freund, K B
2011 Oct;25(10):1379-1380, Eye
— id: 138708, year: 2011, vol: 25, page: 1379, stat: Journal Article,

Spectral and time domain OCT measure identical retinal thickness if identical boundaries are selected for analysis
Engelbert, M; Zweifel, S; Imamura, Y; Fisher, Y L
2010 Jan;24(1):193; author reply 193-193; author reply 194, Eye
— id: 103586, year: 2010, vol: 24, page: 193; author reply 193, stat: Journal Article,

Long-term follow-up for type 1 (subretinal pigment epithelium) neovascularization using a modified "treat and extend" dosing regimen of intravitreal antivascular endothelial growth factor therapy
Engelbert, Michael; Zweifel, Sandrine A; Freund, K Bailey
2010 Oct;30(9):1368-1375, Retina
— id: 138194, year: 2010, vol: 30, page: 1368, stat: Journal Article,

Do we need a new classification for choroidal neovascularization in age-related macular degeneration?
Freund, K Bailey; Zweifel, Sandrine A; Engelbert, Michael
2010 Oct;30(9):1333-1349, Retina
— id: 113905, year: 2010, vol: 30, page: 1333, stat: Journal Article,

Polypoidal choroidal vasculopathy: a review
Imamura, Yutaka; Engelbert, Michael; Iida, Tomohiro; Freund, K Bailey; Yannuzzi, Lawrence A
2010 Nov-Dec;55(6):501-515, Survey of ophthalmology
— id: 113906, year: 2010, vol: 55, page: 501, stat: Journal Article,

Staphylococcus aureus endophthalmitis: antibiotic susceptibilities, methicillin resistance, and clinical outcomes
Major, James C Jr; Engelbert, Michael; Flynn, Harry W Jr; Miller, Darlene; Smiddy, William E; Davis, Janet L
2010 Feb;149(2):278-283.e1, American journal of ophthalmology
— id: 905872, year: 2010, vol: 149, page: 278, stat: Journal Article,

Baylisascaris Procyonis Induced Diffuse Unilateral Subacute Neuroretinitis in New York City
Saffra, Norman A; Perlman, Jason E; Desai, Rajen U; Kazacos, Kevin R; Coyle, Christina M; Machado, Fabiana S; Kedhar, Sanjay R; Engelbert, Michael; Tanowitz, Herbert B
2010 Jan;1:?-?, Journal of neuroparasitology
— id: 201662, year: 2010, vol: 1, page: ?, stat: Journal Article,

"Treat and extend" dosing of intravitreal antivascular endothelial growth factor therapy for type 3 neovascularization/retinal angiomatous proliferation
Engelbert, Michael; Zweifel, Sandrine A; Freund, K Bailey
2009 Nov-Dec;29(10):1424-1431, Retina
— id: 105939, year: 2009, vol: 29, page: 1424, stat: Journal Article,

Evaluation of safety for bilateral same-day intravitreal injections of antivascular endothelial growth factor therapy
Lima, Luiz H; Zweifel, Sandrine A; Engelbert, Michael; Sorenson, John A; Slakter, Jason S; Cooney, Michael J; Klancnik, James M; Yannuzzi, Lawrence A; Freund, K Bailey
2009 Oct;29(9):1213-1217, Retina
— id: 105937, year: 2009, vol: 29, page: 1213, stat: Journal Article,

Prospective study of risk factors for conjunctival bacterial contamination in patients undergoing intraocular surgery
Mino De Kaspar, Herminia; Ta, Christopher N; Froehlich, Stephan J; Schaller, Ulrich C; Engelbert, Michael; Klauss, Volker; Kampik, Anselm
2009 Sep-Oct;19(5):717-722, European journal of ophthalmology
— id: 110222, year: 2009, vol: 19, page: 717, stat: Journal Article,

Retrospective review of the efficacy of topical bromfenac (0.09%) as an adjunctive therapy for patients with neovascular age-related macular degeneration
Zweifel, Sandrine A; Engelbert, Michael; Khan, Samira; Freund, K Bailey
2009 Nov-Dec;29(10):1527-1531, Retina
— id: 105938, year: 2009, vol: 29, page: 1527, stat: Journal Article,

Outer retinal tubulation: a novel optical coherence tomography finding
Zweifel, Sandrine A; Engelbert, Michael; Laud, Ketan; Margolis, Ron; Spaide, Richard F; Freund, K Bailey
2009 Dec;127(12):1596-1602, Archives of ophthalmology (1960)
— id: 105935, year: 2009, vol: 127, page: 1596, stat: Journal Article,

Effects of intravitreal corticosteroid in the treatment of Staphylococcus aureus-induced experimental endophthalmitis
De Kaspar, Herminia Mino; Ta, Christopher N; Engelbert, Michael; Mette, Martina; Thiel, Martin; Kampik, Anselm
2008 Feb;28(2):326-332, Retina
— id: 110212, year: 2008, vol: 28, page: 326, stat: Journal Article,

Magnetic resonance imaging evidence of optic nerve glioma progression into and beyond the optic chiasm
Walrath, Joseph D; Engelbert, Michael; Kazim, Michael
2008 Nov-Dec;24(6):473-475, Ophthalmic plastic & reconstructive surgery
— id: 110219, year: 2008, vol: 24, page: 473, stat: Journal Article,

alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis
Whiston, Emily A; Sugi, Norito; Kamradt, Merideth C; Sack, Coralynn; Heimer, Susan R; Engelbert, Michael; Wawrousek, Eric F; Gilmore, Michael S; Ksander, Bruce R; Gregory, Meredith S
2008 Apr;76(4):1781-1790, Infection & immunity
— id: 905862, year: 2008, vol: 76, page: 1781, stat: Journal Article,

Metastatic endometrial carcinoma resulting in orbital apex compression
Walrath, Joseph D; Lelli, Gary J Jr; Engelbert, Michael; Kazim, Michael
2007 May-Jun;23(3):250-251, Ophthalmic plastic & reconstructive surgery
— id: 110210, year: 2007, vol: 23, page: 250, stat: Journal Article,

Surgical management of pseudophakic retinal detachments: a meta-analysis
Arya, Adarsh V; Emerson, John W; Engelbert, Michael; Hagedorn, Curtis L; Adelman, Ron A
2006 Oct;113(10):1724-1733, Ophthalmology
— id: 110205, year: 2006, vol: 113, page: 1724, stat: Journal Article,

Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis
Engelbert, Michael; Gilmore, Michael S
2005 Jul;46(7):2479-2486, Investigative ophthalmology & visual science. IOVS
— id: 110199, year: 2005, vol: 46, page: 2479, stat: Journal Article,

Intravitreal vancomycin and amikacin versus intravenous imipenem in the treatment of experimental Staphylococcus aureus endophthalmitis
Engelbert, Michael; Mino de Kaspar, Herminia; Thiel, Martin; Grasbon, Thomas; Ta, Christopher N; Schulze-Schwering, Markus; Klauss, Volker; Kampik, Anselm
2004 Apr;242(4):313-320, Graefe's archive for clinincal & experimental ophthalmology
— id: 110195, year: 2004, vol: 242, page: 313, stat: Journal Article,

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis
Engelbert, Michael; Mylonakis, Eleftherios; Ausubel, Frederick M; Calderwood, Stephen B; Gilmore, Michael S
2004 Jun;72(6):3628-3633, Infection & immunity
— id: 905852, year: 2004, vol: 72, page: 3628, stat: Journal Article,

Intravenous treatment of experimental Staphylococcus aureus endophthalmitis: imipenem versus the combination of ceftazidime and amikacin
Engelbert, Michael; Mino de Kaspar, Herminia; Mette, Martina; Thiel, Martin; Ta, Christopher N; Grasbon, Thomas; Schulze-Schwering, Markus; Klauss, Volker; Kampik, Anselm
2003 Dec;241(12):1029-1036, Graefe's archive for clinincal & experimental ophthalmology
— id: 110194, year: 2003, vol: 241, page: 1029, stat: Journal Article,

Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions
Callegan, Michelle C; Engelbert, Michael; Parke, David W 2nd; Jett, Bradley D; Gilmore, Michael S
2002 Jan;15(1):111-124, Clinical microbiology reviews
— id: 905822, year: 2002, vol: 15, page: 111, stat: Journal Article,

Immunology of Staphylococcal biofilm infections in the eye: new tools to study biofilm endophthalmitis
Leid, Jeff G; Costerton, J W; Shirtliff, Mark E; Gilmore, Michael S; Engelbert, Michael
2002 May-Jun;21(5-6):405-413, DNA & cell biology
— id: 905842, year: 2002, vol: 21, page: 405, stat: Journal Article,

Intravenous imipenem prophylaxis in experimental endophthalmitis
Mino de Kaspar, Herminia; Engelbert, Michael; Thiel, Martin; Grasbon, Thomas; Ta, Christopher N; Klauss, Volker; Kampik, Anselm
2002 Jul;240(7):557-564, Graefe's archive for clinincal & experimental ophthalmology
— id: 110188, year: 2002, vol: 240, page: 557, stat: Journal Article,

Rapid direct antibiotic susceptibility testing in endophthalmitis
Mino de Kaspar, Herminia; Neubauer, Aljoscha S; Molnar, Alexander; Hoepfner, Angela S; Ta, Christopher N; Grasbon, Thomas; Engelbert, Michael; Thiel, Martin; Klauss, Volker; Kampik, Anselm
2002 Apr;109(4):687-693, Ophthalmology
— id: 110186, year: 2002, vol: 109, page: 687, stat: Journal Article,

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model
Mylonakis, Eleftherios; Engelbert, Michael; Qin, Xiang; Sifri, Costi D; Murray, Barbara E; Ausubel, Frederick M; Gilmore, Michael S; Calderwood, Stephen B
2002 Aug;70(8):4678-4681, Infection & immunity
— id: 905832, year: 2002, vol: 70, page: 4678, stat: Journal Article,

Antibiotic resistance pattern and visual outcome in experimentally-induced Staphylococcus epidermidis endophthalmitis in a rabbit model
Mino De Kaspar, H; Hoepfner, A S; Engelbert, M; Thiel, M; Ta, C N; Mette, M; Schulze-Schwering, M; Grasbon, T; Sesma-Vea, B; Casas, J M; Iturralde-Goni, R; Klauss, V; Kampik, A
2001 Mar;108(3):470-478, Ophthalmology
— id: 110184, year: 2001, vol: 108, page: 470, stat: Journal Article,

[Bacterial colonization of conjunctiva with Propionibacterium acnes before and after polyvidon iodine administration before intraocular interventions]
Binder, C; de Kaspar, H M; Engelbert, M; Klauss, V; Kampik, A
1998 Jun;95(6):438-441, Ophthalmologe
— id: 110231, year: 1998, vol: 95, page: 438, stat: Journal Article,