Brian David Dynlacht

Biosketch / Results /

Brian David Dynlacht, Ph.D.

Professor; Scientific Director -Genomics Facility
Department of Pathology

Contact Info

522 First Avenue
Floor 11 Room 1104
Smilow Research Building
New York, NY 10016


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— Harvard Medical School, PostDoctoral Training
— University of California, Berkeley, Graduate Education
1992 — Univ of Calif Berkeley, Medical Education

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Research Summary

Our research program has taken advantage of multiple, complementary approaches, each aimed at understanding the mechanisms underlying progression through the mammalian cell cycle. In particular, we have chosen to focus on transcriptional mechanisms that link gene expression with cell cycle progression.
These studies have largely centered on the retinoblastoma tumor suppressor protein, pRB, and the related proteins p107 and p130. pRB is a prototypical tumor suppressor known to be mutated in many human tumors. pRB and its relatives restrain cell growth by inhibiting the activity of a cellular transcription factor, E2F, that controls the expression of key components of the cell cycle and DNA replication machinery. Using a combination of biochemistry, cell biology, and mutant cell lines, we are attempting to understand how critical gene targets are regulated by E2F and pRB. We have combined the use of a technique known as chromatin immunoprecipitation (ChIP) with a genomic approach employing DNA microarray analysis in order to begin understanding how gene regulatory networks are controlled during the cell cycle and differentiation in living mammalian cells. The pRB family controls a number of developmental decisions as well as cell cycle arrest in response to DNA damage. We hope to uncover novel targets of pRB that reveal a regulatory pathway of biologically relevant, functional interactions that drive cells toward each of these fates.
In addition to studies aimed at addressing transcriptional control of the cell cycle, we are also focusing on understanding another event linked to the cell cycle, namely duplication of centrosomes. The centrosome, involved in organizing the mitotic spindle, is poorly understood, although it was first observed 100 years ago. We have identified a novel protein, CP110, that may link the duplication of this organelle to the cell cycle. Since genomic instability ensues when CP110 is mutated, we are investigating potential links between this protein and human cancer.

Supplementary figures for Balciunaite et. al., MCB, 2005.

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All data from NYU Health Sciences Library Faculty Bibliography — -


Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs
Bowman, Christopher John; Ayer, Donald E; Dynlacht, Brian David
2014 Nov;:S59-S65, Nature cell biology
— id: 1355692, year: 2014, vol: , page: S59, stat: Journal Article,

A Role for H3K4 Monomethylation in Gene Repression and Partitioning of Chromatin Readers
Cheng, Jemmie; Blum, Roy; Bowman, Christopher; Hu, Deqing; Shilatifard, Ali; Shen, Steven; Dynlacht, Brian D
2014 Mar;53(6):979-992, Molecular cell
— id: 917822, year: 2014, vol: 53, page: 979, stat: Journal Article,

Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma
Fu, Wenxiang; Asp, Patrik; Canter, Brian; Dynlacht, Brian David
2014 Jun;:110-120, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 1033962, year: 2014, vol: , page: 110, stat: Journal Article,

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly
Kobayashi, Tetsuo; Kim, Sehyun; Lin, Yu-Chun; Inoue, Takanari; Dynlacht, Brian David
2014 Jan;204(2):215-229, Journal of cell biology
— id: 759852, year: 2014, vol: 204, page: 215, stat: Journal Article,

Cell biology: Short RNAs and shortness of breath
Sanchez, Irma; Dynlacht, Brian D
2014 Jun;510(7503):40-42, Nature
— id: 1061982, year: 2014, vol: 510, page: 40, stat: Journal Article,

The role of MyoD1 and histone modifications in the activation of muscle enhancers
Blum, Roy; Dynlacht, Brian D
2013 Aug;8(8):778-784, Epigenetics
— id: 586192, year: 2013, vol: 8, page: 778, stat: Journal Article,

Centrosomes tune in to metabolic state and turn on to oxygen
Kim, Sehyun; Dynlacht, Brian D
2013 Aug;26(4):325-326, Developmental cell
— id: 519492, year: 2013, vol: 26, page: 325, stat: Journal Article,

Assembling a primary cilium
Kim, Sehyun; Dynlacht, Brian David
2013 Aug;25(4):506-511, Current opinion in cell biology
— id: 463532, year: 2013, vol: 25, page: 506, stat: Journal Article,

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
Li, Ji; D'Angiolella, Vincenzo; Seeley, E Scott; Kim, Sehyun; Kobayashi, Tetsuo; Fu, Wenxiang; Campos, Eric I; Pagano, Michele; Dynlacht, Brian David
2013 Mar;495(7440):255-259, Nature
— id: 242352, year: 2013, vol: 495, page: 255, stat: Journal Article,

Morbid Obesity Resulting from Inactivation of the Ciliary Protein CEP19 in Humans and Mice
Shalata, Adel; Ramirez, Maria C; Desnick, Robert J; Priedigkeit, Nolan; Buettner, Christoph; Lindtner, Claudia; Mahroum, Mohammed; Abdul-Ghani, Muhammad; Dong, Feng; Arar, Nazik; Camacho-Vanegas, Olga; Zhang, Rui; Camacho, Sandra C; Chen, Ying; Ibdah, Mwafaq; Defronzo, Ralph; Gillespie, Virginia; Kelley, Kevin; Dynlacht, Brian D; Kim, Sehyun; Glucksman, Marc J; Borochowitz, Zvi U; Martignetti, John A
2013 Dec;93(6):1061-1071, American journal of human genetics
— id: 746622, year: 2013, vol: 93, page: 1061, stat: Journal Article,

CP110 and its network of partners coordinately regulate cilia assembly
Tsang, William Y; Dynlacht, Brian D
2013 ;2(1):9-9, Cilia
— id: 760342, year: 2013, vol: 2, page: 9, stat: Journal Article,

Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1
Blum, Roy; Vethantham, Vasupradha; Bowman, Christopher; Rudnicki, Michael; Dynlacht, Brian D
2012 Dec;26(24):2763-2779, Genes & development
— id: 214972, year: 2012, vol: 26, page: 2763, stat: Journal Article,

Centrosome homeostasis is controlled by ubiquitylation and deubiquitylation cycles
Li, J; D'Angiolella, V; Seeley, E; Kobayashi, T; Kim, S; Pagano, M; Dynlacht, B
2012 15 Dec 2012;23(24):-, Molecular biology of the cell
— id: 884432, year: 2012, vol: 23, page: , stat: Journal Article,

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres
Li, J; Kim, S; Kobayashi, T; Liang, FX; Korzeniewski, N; Duensing, S; Dynlacht, BD
2012 Mar;:547-553, EMBO reports
— id: 162560, year: 2012, vol: , page: 547, stat: Journal Article,

Regulation of a novel androgen receptor target gene, cyclin B1, through androgen-dependent E2F family member switching
Li, Y; Zhang, DY; Ren, Q; Ye, F; Zhao, X; Daniels, G; Wu, X; Dynlacht, B; Lee, P
2012 Apr;:2454-2466, Molecular & cellular biology
— id: 164476, year: 2012, vol: , page: 2454, stat: Journal Article,

Picking ChIP-seq peak detectors for analyzing chromatin modification experiments
Micsinai, M; Parisi, F; Strino, F; Asp, P; Dynlacht, BD; Kluger, Y
2012 Feb;:e70-e70, Nucleic acids research
— id: 162561, year: 2012, vol: , page: e70, stat: Journal Article,

Dynamic Loss of H2B Ubiquitylation without Corresponding Changes in H3K4 Trimethylation during Myogenic Differentiation
Vethantham, Vasupradha; Yang, Yan; Bowman, Christopher; Asp, Patrik; Lee, Jeong-Heon; Skalnik, David G; Dynlacht, Brian D
2012 Mar;32(6):1044-1055, Molecular & cellular biology
— id: 160249, year: 2012, vol: 32, page: 1044, stat: Journal Article,

PNAS Plus: Genome-wide remodeling of the epigenetic landscape during myogenic differentiation
Asp, Patrik; Blum, Roy; Vethantham, Vasupradha; Parisi, Fabio; Micsinai, Mariann; Cheng, Jemmie; Bowman, Christopher; Kluger, Yuval; Dynlacht, Brian David
2011 May 31;108(22):E149-E158, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 133464, year: 2011, vol: 108, page: E149, stat: Journal Article,

Regulating the transition from centriole to basal body
Kobayashi, Tetsuo; Dynlacht, Brian D
2011 May 2;193(3):435-444, Journal of cell biology
— id: 134200, year: 2011, vol: 193, page: 435, stat: Journal Article,

Centriolar Kinesin Kif24 Interacts with CP110 to Remodel Microtubules and Regulate Ciliogenesis
Kobayashi, Tetsuo; Tsang, William Y; Li, Ji; Lane, William; Dynlacht, Brian David
2011 Jun 10;145(6):914-925, Cell
— id: 134452, year: 2011, vol: 145, page: 914, stat: Journal Article,

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
D'Angiolella, Vincenzo; Donato, Valerio; Vijayakumar, Sangeetha; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Dynlacht, Brian; Pagano, Michele
2010 Jul 1;466(7302):138-142, Nature
— id: 110690, year: 2010, vol: 466, page: 138, stat: Journal Article,

Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis
Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D
2010 Dec;11(12):969-976, EMBO reports
— id: 114826, year: 2010, vol: 11, page: 969, stat: Journal Article,

The Mammalian sin3 proteins are required for muscle development and sarcomere specification
van Oevelen, Chris; Bowman, Christopher; Pellegrino, Jessica; Asp, Patrik; Cheng, Jemmie; Parisi, Fabio; Micsinai, Mariann; Kluger, Yuval; Chu, Alphonse; Blais, Alexandre; David, Gregory; Dynlacht, Brian D
2010 Dec;30(24):5686-5697, Molecular & cellular biology
— id: 114827, year: 2010, vol: 30, page: 5686, stat: Journal Article,

E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation
Asp, Patrik; Acosta-Alvear, Diego; Tsikitis, Mary; van Oevelen, Chris; Dynlacht, Brian David
2009 Jan 1;23(1):37-53, Genes & development
— id: 92188, year: 2009, vol: 23, page: 37, stat: Journal Article,

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Galluzzi, L; Aaronson, S A; Abrams, J; Alnemri, E S; Andrews, D W; Baehrecke, E H; Bazan, N G; Blagosklonny, M V; Blomgren, K; Borner, C; Bredesen, D E; Brenner, C; Castedo, M; Cidlowski, J A; Ciechanover, A; Cohen, G M; De Laurenzi, V; De Maria, R; Deshmukh, M; Dynlacht, B D; El-Deiry, W S; Flavell, R A; Fulda, S; Garrido, C; Golstein, P; Gougeon, M-L; Green, D R; Gronemeyer, H; Hajnoczky, G; Hardwick, J M; Hengartner, M O; Ichijo, H; Jaattela, M; Kepp, O; Kimchi, A; Klionsky, D J; Knight, R A; Kornbluth, S; Kumar, S; Levine, B; Lipton, S A; Lugli, E; Madeo, F; Malomi, W; Marine, J-C W; Martin, S J; Medema, J P; Mehlen, P; Melino, G; Moll, U M; Morselli, E; Nagata, S; Nicholson, D W; Nicotera, P; Nunez, G; Oren, M; Penninger, J; Pervaiz, S; Peter, M E; Piacentini, M; Prehn, J H M; Puthalakath, H; Rabinovich, G A; Rizzuto, R; Rodrigues, C M P; Rubinsztein, D C; Rudel, T; Scorrano, L; Simon, H-U; Steller, H; Tschopp, J; Tsujimoto, Y; Vandenabeele, P; Vitale, I; Vousden, K H; Youle, R J; Yuan, J; Zhivotovsky, B; Kroemer, G
2009 Aug;16(8):1093-1107, Cell death & differentiation
— id: 162564, year: 2009, vol: 16, page: 1093, stat: Journal Article,

Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP
Kohlmaier, Gregor; Loncarek, Jadranka; Meng, Xing; McEwen, Bruce F; Mogensen, Mette M; Spektor, Alexander; Dynlacht, Brian D; Khodjakov, Alexey; Gonczy, Pierre
2009 Jun;19(12):1012-1018, Current biology. CB
— id: 162562, year: 2009, vol: 19, page: 1012, stat: Journal Article,

Cep76, a centrosomal protein that specifically restrains centriole reduplication
Tsang, William Y; Spektor, Alexander; Vijayakumar, Sangeetha; Bista, Bigyan R; Li, Ji; Sanchez, Irma; Duensing, Stefan; Dynlacht, Brian D
2009 May;16(5):649-660, Developmental cell
— id: 99216, year: 2009, vol: 16, page: 649, stat: Journal Article,

Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells
Bar-Joseph, Ziv; Siegfried, Zahava; Brandeis, Michael; Brors, Benedikt; Lu, Yong; Eils, Roland; Dynlacht, Brian D; Simon, Itamar
2008 Jan 22;105(3):955-960, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 135315, year: 2008, vol: 105, page: 955, stat: Journal Article,

Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions
Dynlacht, Brian David
2008 Jan;13(1):1-2, Cancer cell
— id: 75774, year: 2008, vol: 13, page: 1, stat: Journal Article,

Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D
Lents, Nathan H; Wheeler, Leroy W; Baldassare, Joseph J; Dynlacht, Brian David
2008 Jun 1;7(11):1580-1586, Cell cycle
— id: 96442, year: 2008, vol: 7, page: 1580, stat: Journal Article,

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
Margueron, Raphael; Li, Guohong; Sarma, Kavitha; Blais, Alexandre; Zavadil, Jiri; Woodcock, Christopher L; Dynlacht, Brian D; Reinberg, Danny
2008 Nov 21;32(4):503-518, Molecular cell
— id: 91489, year: 2008, vol: 32, page: 503, stat: Journal Article,

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease
Tsang, William Y; Bossard, Carine; Khanna, Hemant; Peranen, Johan; Swaroop, Anand; Malhotra, Vivek; Dynlacht, Brian David
2008 Aug;15(2):187-197, Developmental cell
— id: 83106, year: 2008, vol: 15, page: 187, stat: Journal Article,

Double identity of SCAPER: a substrate and regulator of cyclin A/Cdk2
Tsang, William Y; Dynlacht, Brian David
2008 Mar 15;7(6):702-705, Cell cycle
— id: 84017, year: 2008, vol: 7, page: 702, stat: Journal Article,

sSgo1, a guardian of centriole cohesion
Tsang, William Y; Dynlacht, Brian David
2008 Mar;14(3):320-322, Developmental cell
— id: 78023, year: 2008, vol: 14, page: 320, stat: Journal Article,

A role for mammalian Sin3 in permanent gene silencing
van Oevelen, Chris; Wang, Jinhua; Asp, Patrik; Yan, Qin; Kaelin, William G Jr; Kluger, Yuval; Dynlacht, Brian David
2008 Nov 7;32(3):359-370, Molecular cell
— id: 90059, year: 2008, vol: 32, page: 359, stat: Journal Article,

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
Acosta-Alvear, Diego; Zhou, Yiming; Blais, Alexandre; Tsikitis, Mary; Lents, Nathan H; Arias, Carolina; Lennon, Christen J; Kluger, Yuval; Dynlacht, Brian David
2007 Jul 6;27(1):53-66, Molecular cell
— id: 73301, year: 2007, vol: 27, page: 53, stat: Journal Article,

E2F-associated chromatin modifiers and cell cycle control
Blais, Alexandre; Dynlacht, Brian D
2007 Dec;19(6):658-662, Current opinion in cell biology
— id: 162563, year: 2007, vol: 19, page: 658, stat: Journal Article,

Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
Blais, Alexandre; van Oevelen, Chris J C; Margueron, Raphael; Acosta-Alvear, Diego; Dynlacht, Brian David
2007 Dec 31;179(7):1399-1412, Journal of cell biology
— id: 96443, year: 2007, vol: 179, page: 1399, stat: Journal Article,

Functional genomics via multiscale analysis: application to gene expression and ChIP-on-chip data
Lerman, Gilad; McQuown, Joseph; Blais, Alexandre; Dynlacht, Brian D; Chen, Guangliang; Mishra, Bud
2007 Feb 1;23(3):314-320, Bioinformatics
— id: 71651, year: 2007, vol: 23, page: 314, stat: Journal Article,

Cep97 and CP110 Suppress a Cilia Assembly Program
Spektor, Alexander; Tsang, William Y; Khoo, David; Dynlacht, Brian David
2007 Aug 24;130(4):678-690, Cell
— id: 73828, year: 2007, vol: 130, page: 678, stat: Journal Article,

SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression
Tsang, William Y; Wang, Leyu; Chen, Zhihong; Sanchez, Irma; Dynlacht, Brian David
2007 Aug 13;178(4):621-633, Journal of cell biology
— id: 73586, year: 2007, vol: 178, page: 621, stat: Journal Article,

CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability
Tsang, William Y; Spektor, Alexander; Luciano, Daniel J; Indjeian, Vahan B; Chen, Zhihong; Salisbury, Jeffery L; Sanchez, Irma; Dynlacht, Brian David
2006 Aug;17(8):3423-3434, Molecular biology of the cell
— id: 66471, year: 2006, vol: 17, page: 3423, stat: Journal Article,

Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells
Balciunaite, Egle; Spektor, Alexander; Lents, Nathan H; Cam, Hugh; Te Riele, Hein; Scime, Anthony; Rudnicki, Michael A; Young, Richard; Dynlacht, Brian David
2005 Sep;25(18):8166-8178, Molecular & cellular biology
— id: 58713, year: 2005, vol: 25, page: 8166, stat: Journal Article,

Constructing transcriptional regulatory networks
Blais, Alexandre; Dynlacht, Brian David
2005 Jul 1;19(13):1499-1511, Genes & development
— id: 58064, year: 2005, vol: 19, page: 1499, stat: Journal Article,

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells
Chen, Zhihong; Indjeian, Vahan B; McManus, Michael; Wang, Leyu; Dynlacht, Brian David
2002 Sep;3(3):339-350, Developmental cell
— id: 33140, year: 2002, vol: 3, page: 339, stat: Journal Article,

E2F4 loss suppresses tumorigenesis in Rb mutant mice
Lee, Eunice Y; Cam, Hieu; Ziebold, Ulrike; Rayman, Joseph B; Lees, Jacqueline A; Dynlacht, Brian David
2002 Dec;2(6):463-472, Cancer cell
— id: 33139, year: 2002, vol: 2, page: 463, stat: Journal Article,

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
Rayman, Joseph B; Takahashi, Yasuhiko; Indjeian, Vahan B; Dannenberg, Jan-Hermen; Catchpole, Steven; Watson, Roger J; te Riele, Hein; Dynlacht, Brian David
2002 Apr 15;16(8):933-947, Genes & development
— id: 33141, year: 2002, vol: 16, page: 933, stat: Journal Article,

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
Ren, Bing; Cam, Hieu; Takahashi, Yasuhiko; Volkert, Thomas; Terragni, Jolyon; Young, Richard A; Dynlacht, Brian David
2002 Jan 15;16(2):245-256, Genes & development
— id: 33142, year: 2002, vol: 16, page: 245, stat: Journal Article,

Transcriptional regulation of cell cycle progression
Dynlacht BD
Transcription factors Oxford : BIOS, Academic Press, 2001,
— id: 2840, year: 2001, vol: , page: ?, stat: Chapter,

Active repression and E2F inhibition by pRB are biochemically distinguishable
Ross JF; Naar A; Cam H; Gregory R; Dynlacht BD
2001 Feb 15;15(4):392-397, Genes & development
— id: 33143, year: 2001, vol: 15, page: 392, stat: Journal Article,

Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation
Schang LM; Hwang GJ; Dynlacht BD; Speicher DW; Bantly A; Schaffer PA; Shilatifard A; Ge H; Shiekhattar R
2000 Mar 3;275(9):6071-6074, Journal of biological chemistry
— id: 33145, year: 2000, vol: 275, page: 6071, stat: Journal Article,

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression
Takahashi Y; Rayman JB; Dynlacht BD
2000 Apr 1;14(7):804-816, Genes & development
— id: 33144, year: 2000, vol: 14, page: 804, stat: Journal Article,

Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein
Ross JF; Liu X; Dynlacht BD
1999 Feb;3(2):195-205, Molecular cell
— id: 33146, year: 1999, vol: 3, page: 195, stat: Journal Article,

Activity and nature of p21(WAF1) complexes during the cell cycle
Cai K; Dynlacht BD
1998 Oct 13;95(21):12254-12259, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 33147, year: 1998, vol: 95, page: 12254, stat: Journal Article,

Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
Castano E; Kleyner Y; Dynlacht BD
1998 Sep;18(9):5380-5391, Molecular & cellular biology
— id: 33148, year: 1998, vol: 18, page: 5380, stat: Journal Article,

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
Zhao J; Dynlacht B; Imai T; Hori T; Harlow E
1998 Feb 15;12(4):456-461, Genes & development
— id: 33170, year: 1998, vol: 12, page: 456, stat: Journal Article,

Regulation of transcription by proteins that control the cell cycle
Dynlacht BD
1997 Sep 11;389(6647):149-152, Nature
— id: 33149, year: 1997, vol: 389, page: 149, stat: Journal Article,

Specific regulation of E2F family members by cyclin-dependent kinases
Dynlacht BD; Moberg K; Lees JA; Harlow E; Zhu L
1997 Jul;17(7):3867-3875, Molecular & cellular biology
— id: 33150, year: 1997, vol: 17, page: 3867, stat: Journal Article,

Purification and analysis of CIP/KIP proteins
Dynlacht BD; Ngwu C; Winston J; Swindell EC; Elledge SJ; Harlow E; Harper JW
1997 ;283(7):230-244, Methods in enzymology
— id: 33152, year: 1997, vol: 283, page: 230, stat: Journal Article,

p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
Woo MS; Sanchez I; Dynlacht BD
1997 Jul;17(7):3566-3579, Molecular & cellular biology
— id: 33151, year: 1997, vol: 17, page: 3566, stat: Journal Article,

Cyclin-binding motifs are essential for the function of p21CIP1
Chen J; Saha P; Kornbluth S; Dynlacht BD; Dutta A
1996 Sep;16(9):4673-4682, Molecular & cellular biology
— id: 33153, year: 1996, vol: 16, page: 4673, stat: Journal Article,

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins
Goldberg Y; Nassif II; Pittas A; Tsai LL; Dynlacht BD; Rigas B; Shiff SJ
1996 Feb 15;12(4):893-901, Oncogene
— id: 33155, year: 1996, vol: 12, page: 893, stat: Journal Article,

Transcriptional control of the cell cycle
Sanchez I; Dynlacht BD
1996 Jun;8(3):318-324, Current opinion in cell biology
— id: 33154, year: 1996, vol: 8, page: 318, stat: Journal Article,

Retinoblastoma protein. Pol I gets repressed
Dynlacht BD
1995 Mar 9;374(6518):114-114, Nature
— id: 33158, year: 1995, vol: 374, page: 114, stat: Journal Article,

Inhibition of cyclin-dependent kinases by p21
Harper JW; Elledge SJ; Keyomarsi K; Dynlacht B; Tsai LH; Zhang P; Dobrowolski S; Bai C; Connell-Crowley L; Swindell E; et al.
1995 Apr;6(4):387-400, Molecular biology of the cell
— id: 33169, year: 1995, vol: 6, page: 387, stat: Journal Article,

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
Koh J; Enders GH; Dynlacht BD; Harlow E
1995 Jun 8;375(6531):506-510, Nature
— id: 33157, year: 1995, vol: 375, page: 506, stat: Journal Article,

Cdk-activating kinase complex is a component of human transcription factor TFIIH
Shiekhattar R; Mermelstein F; Fisher RP; Drapkin R; Dynlacht B; Wessling HC; Morgan DO; Reinberg D
1995 Mar 16;374(6519):283-287, Nature
— id: 33168, year: 1995, vol: 374, page: 283, stat: Journal Article,

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
Zhu L; Harlow E; Dynlacht BD
1995 Jul 15;9(14):1740-1752, Genes & development
— id: 33156, year: 1995, vol: 9, page: 1740, stat: Journal Article,

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins
Dynlacht BD; Brook A; Dembski M; Yenush L; Dyson N
1994 Jul 5;91(14):6359-6363, Proceedings of the National Academy of Sciences of the United States of America (PNAS)
— id: 33160, year: 1994, vol: 91, page: 6359, stat: Journal Article,

Differential regulation of E2F transactivation by cyclin/cdk2 complexes
Dynlacht BD; Flores O; Lees JA; Harlow E
1994 Aug 1;8(15):1772-1786, Genes & development
— id: 33159, year: 1994, vol: 8, page: 1772, stat: Journal Article,

The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats
Dynlacht BD; Weinzierl RO; Admon A; Tjian R
1993 May 13;363(6425):176-179, Nature
— id: 33162, year: 1993, vol: 363, page: 176, stat: Journal Article,

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
Hoey T; Weinzierl RO; Gill G; Chen JL; Dynlacht BD; Tjian R
1993 Jan 29;72(2):247-260, Cell
— id: 33164, year: 1993, vol: 72, page: 247, stat: Journal Article,

Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator
Weinzierl RO; Dynlacht BD; Tjian R
1993 Apr 8;362(6420):511-517, Nature
— id: 33163, year: 1993, vol: 362, page: 511, stat: Journal Article,

Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID
Weinzierl RO; Ruppert S; Dynlacht BD; Tanese N; Tjian R
1993 Dec 15;12(13):5303-5309, EMBO journal
— id: 33161, year: 1993, vol: 12, page: 5303, stat: Journal Article,

Biochemical characterization of the Drosophila transcription factor NTF-1 and the TFIID complex
Dynlacht, Brian David
[S.l. : s.n.], 1992,
— id: 1109, year: 1992,