Michael L Dustin

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Michael Dustin

Research Professor, Department of Pathology
Skirball Institute

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212/263-3207
Michael.Dustin@med.nyu.edu


Research Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

Research Interests

Cell adhesion, T cell activation, immunological synapse, immune cell migration, microscopy

T cells have a light touch
Dustin, Michael L
2015-05-11; 1542-0086,Biophysical journal - id: 1569712, year: 2015 Journal Article

Pillars article: the immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227
Grakoui, Arash; Bromley, Shannon K; Sumen, Cenk; Davis, Mark M; Shaw, Andrey S; Allen, Paul M; Dustin, Michael L
2015-04-20; 1550-6606,Journal of immunology (1950) - id: 1533492, year: 2015 Journal Article

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node-Homing Adipose Tissue Dendritic Cells
Kuan, Emma L; Ivanov, Stoyan; Bridenbaugh, Eric A; Victora, Gabriel; Wang, Wei; Childs, Ed W; Platt, Andrew M; Jakubzick, Claudia V; Mason, Robert J; Gashev, Anatoliy A; Nussenzweig, Michel; Swartz, Melody A; Dustin, Michael L; Zawieja, David C; Randolph, Gwendalyn J
2015-05-04; 1550-6606,Journal of immunology (1950) - id: 1556952, year: 2015 JOURNAL ARTICLE

Actin foci facilitate activation of the phospholipase C-gamma in primary T lymphocytes via the WASP pathway
Kumari, Sudha; Depoil, David; Martinelli, Roberta; Judokusumo, Edward; Carmona, Guillaume; Gertler, Frank B; Kam, Lance C; Carman, Christopher V; Burkhardt, Janis K; Irvine, Darrell J; Dustin, Michael L
2015-03-16; 2050-084x,eLife - id: 1494892, year: 2015 Journal Article

Syk and src family kinases regulate c-type lectin receptor 2 (clec-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells
Pollitt, A Y; Poulter, N S; Gitz, E; Navarro-Nunez, L; Wang, Y -J; Hughes, C E; Thomas, S G; Nieswandt, B; Douglas, M R; Owen, D M; Jackson, D G; Dustin, M L; Watson, S P
2015-02-03; 0021-9258,Journal of biological chemistry - id: 1449132, year: 2015