Biosketch / Results /
Michael DustinResearch Professor, Department of Pathology
540-562 First Avenue
New York, NY 10016
Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.
Research Keywordscell adhesion, T-cell activation, immunological synapse, immune cell migration, microscopy
Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis
Fu, Wenyu; Hu, Wenhuo; Shi, Lei; Mundra, Jyoti Joshi; Xiao, GuoZhi; Dustin, Michael L; Liu, Chuan-Ju. Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis. FASEB journal. 2016 Dec 23;:?-? (2374632)
HIV envelope gp120 alters T-cell receptor mobilization in the immunological synapse of uninfected CD4 T cells and augments the T cell activation
Deng, Jing; Mitsuki, Yu-Ya; Shen, Guomiao; Ray, Jocelyn; Cicala, Claudia; Arthos, James; Dustin, Michael L; Hioe, Catarina E. HIV envelope gp120 alters T-cell receptor mobilization in the immunological synapse of uninfected CD4 T cells and augments the T cell activation. Journal of virology. 2016 Dec 01;90(23):10513-10526 (2247052)
What Scales the T Cell Response?
Mayya, Viveka; Dustin, Michael L. What Scales the T Cell Response?. Trends in immunology. 2016 Aug;37(8):513-522 (2167142)
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
Saha, Asim; O'Connor, Roddy S; Thangavelu, Govindarajan; Lovitch, Scott B; Dandamudi, Durga Bhavani; Wilson, Caleph B; Vincent, Benjamin G; Tkachev, Victor; Pawlicki, Jan M; Furlan, Scott N; Kean, Leslie S; Aoyama, Kazutoshi; Taylor, Patricia A; Panoskaltsis-Mortari, Angela; Foncea, Rocio; Ranganathan, Parvathi; Devine, Steven M; Burrill, Joel S; Guo, Lili; Sacristan, Catarina; Snyder, Nathaniel W; Blair, Ian A; Milone, Michael C; Dustin, Michael L; Riley, James L; Bernlohr, David A; Murphy, William J; Fife, Brian T; Munn, David H; Miller, Jeffrey S; Serody, Jonathan S; Freeman, Gordon J; Sharpe, Arlene H; Turka, Laurence A; Blazar, Bruce R. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. Journal of clinical investigation. 2016 Jul 01;126(7):2642-2660 (2188162)
Size-dependent protein segregation at membrane interfaces
Schmid, Eva M; Bakalar, Matthew H; Choudhuri, Kaushik; Weichsel, Julian; Ann, HyoungSook; Geissler, Phillip L; Dustin, Michael L; Fletcher, Daniel A. Size-dependent protein segregation at membrane interfaces. Nature physics. 2016 Jul;12(7):704-711 (2363672)