Michael L Dustin

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Michael Dustin

Research Professor, Department of Pathology
Skirball Institute

Contact Info

540-562 First Avenue
New York, NY 10016


Research Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

Research Interests

Cell adhesion, T cell activation, immunological synapse, immune cell migration, microscopy

Actin foci facilitate activation of the phospholipase C-gamma in primary T lymphocytes via the WASP pathway
Kumari, Sudha; Depoil, David; Martinelli, Roberta; Judokusumo, Edward; Carmona, Guillaume; Gertler, Frank B; Kam, Lance C; Carman, Christopher V; Burkhardt, Janis K; Irvine, Darrell J; Dustin, Michael L
2015-03-16; 2050-084x,eLife - id: 1494892, year: 2015 Journal Article

Syk and src family kinases regulate c-type lectin receptor 2 (clec-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells
Pollitt, A Y; Poulter, N S; Gitz, E; Navarro-Nunez, L; Wang, Y -J; Hughes, C E; Thomas, S G; Nieswandt, B; Douglas, M R; Owen, D M; Jackson, D G; Dustin, M L; Watson, S P
2015-02-03; 0021-9258,Journal of biological chemistry - id: 1449132, year: 2015

Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility
Bashour, KT; Tsai, J; Shen, K; Lee, J-H; Sun, E; Milone, MC; Dustin, ML; Kam, LC
2014-06-03; 0270-7306,Molecular & cellular biology - id: 1021432, year: 2014

Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells
Cespedes, Pablo F; Bueno, Susan M; Ramirez, Bruno A; Gomez, Roberto S; Riquelme, Sebastian A; Palavecino, Christian E; Mackern-Oberti, Juan Pablo; Mora, Jorge E; Depoil, David; Sacristan, Catarina; Cammer, Michael; Creneguy, Alison; Nguyen, Tuan H; Riedel, Claudia A; Dustin, Michael L; Kalergis, Alexis M
2014-07-25; 0027-8424,Proceedings of the National Academy of Sciences of the United States of America (PNAS) - id: 1076122, year: 2014 JOURNAL ARTICLE

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse
Choudhuri, Kaushik; Llodra, Jaime; Roth, Eric W; Tsai, Jones; Gordo, Susana; Wucherpfennig, Kai W; Kam, Lance C; Stokes, David L; Dustin, Michael L
2014-03-03; 0028-0836,Nature - id: 820872, year: 2014 JOURNAL ARTICLE