Michael L Dustin

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Michael Dustin

Research Professor, Department of Pathology
Coord Molecular Pathogenesis Prog

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212/263-3207
Michael.Dustin@med.nyu.edu


Research Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

Research Interests

Cell adhesion, T cell activation, immunological synapse, immune cell migration, microscopy

Molecular Occupancy of Nanodot Arrays
Cai, Haogang; Wolfenson, Haguy; Depoil, David; Dustin, Michael L; Sheetz, Michael P; Wind, Shalom J. Molecular Occupancy of Nanodot Arrays. ACS nano. 2016 Mar 15;10(4):4173-4183 (2046882)

Agile CD22 nanoclusters run rings around fenced BCR
Depoil, David; Dustin, Michael L. Agile CD22 nanoclusters run rings around fenced BCR. EMBO journal. 2016 Jan 1;35(3):237-238 (2042842)

Cancer immunotherapy: Killers on sterols
Dustin, Michael L. Cancer immunotherapy: Killers on sterols. Nature. 2016 Mar 16;531(7596):583-584 (2047312)

Phagocytes Get Close to Their Enemies
Dustin, Michael L; Davis, Simon J. Phagocytes Get Close to Their Enemies. Developmental cell. 2016 Jan 25;36(2):131-132 (2043902)

CELL SIGNALING. Liquidity in immune cell signaling
Dustin, Michael L; Muller, James. CELL SIGNALING. Liquidity in immune cell signaling [Comment]. Science. 2016 Apr;352(6285):516-517 (2092632)