Michael L Dustin

Biosketch / Results /

Michael Dustin

Research Professor, Department of Pathology

Contact Info

Address
540-562 First Avenue
New York, NY 10016

212-263-3207
Michael.Dustin@med.nyu.edu


Research Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

Research Keywords

cell adhesion, T-cell activation, immunological synapse, immune cell migration, microscopy

Membrane nanoclusters of FcgammaRI segregate from inhibitory SIRPalpha upon activation of human macrophages
Lopes, Filipa B; Balint, Stefan; Valvo, Salvatore; Felce, James H; Hessel, Edith M; Dustin, Michael L; Davis, Daniel M. Membrane nanoclusters of FcgammaRI segregate from inhibitory SIRPalpha upon activation of human macrophages. Journal of cell biology. 2017 Mar 13;:?-? (2489682)

Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation
Cai, Haogang; Depoil, David; Muller, James; Sheetz, Michael P; Dustin, Michael L; Wind, Shalom J. Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation. Methods in molecular biology. 2017 ;1584:307-331 (2471612)

The Immune Synapse: Past, Present, and Future
Dustin, Michael L; Baldari, Cosima T. The Immune Synapse: Past, Present, and Future. Methods in molecular biology. 2017 ;1584:1-5 (2471602)

Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis
Fu, Wenyu; Hu, Wenhuo; Shi, Lei; Mundra, Jyoti Joshi; Xiao, GuoZhi; Dustin, Michael L; Liu, Chuan-Ju. Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis. FASEB journal. 2016 Dec 23;:?-? (2374632)

HIV envelope gp120 alters T-cell receptor mobilization in the immunological synapse of uninfected CD4 T cells and augments the T cell activation
Deng, Jing; Mitsuki, Yu-Ya; Shen, Guomiao; Ray, Jocelyn; Cicala, Claudia; Arthos, James; Dustin, Michael L; Hioe, Catarina E. HIV envelope gp120 alters T-cell receptor mobilization in the immunological synapse of uninfected CD4 T cells and augments the T cell activation. Journal of virology. 2016 Dec 01;90(23):10513-10526 (2247052)