Heran Darwin

Biosketch / Results /

Heran Darwin, Ph.D.

Professor;
Department of Microbiology (Microbiology )

Contact Info

Address
550 First Avenue
Floor 2 Room 236A
Medical Science Building
New York, NY 10016-6481

212-263-2624
212-263-2624
Heran.Darwin@med.nyu.edu


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All data from NYU Health Sciences Library Faculty Bibliography — -

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http://hsl.med.nyu.edu/faculty-bibliography-search

The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence
Shi, Xiaoshan; Festa, Richard A; Ioerger, Thomas R; Butler-Wu, Susan; Sacchettini, James C; Darwin, K Heran; Samanovic, Marie I
2014 ;5(1):65-70, MBio
— id: 953442, year: 2014, vol: 5, page: 65, stat: Journal Article,

Mycobacterium tuberculosis proteasomes, pupylation and pathogenesis
Darwin, K H
2013 April 2013;27:-, FASEB journal
— id: 550852, year: 2013, vol: 27, page: , stat: Journal Article,

The Pup-Proteasome System of Mycobacterium tuberculosis
Samanovic, Marie I; Li, Huilin; Darwin, K Heran
2013 ;66:267-295, Sub-cellular biochemistry
— id: 242312, year: 2013, vol: 66, page: 267, stat: Journal Article,

Pupylation: proteasomal targeting by a protein modifier in bacteria
Burns, Kristin E; Darwin, K Heran
2012 ;832:151-160, Methods in molecular biology
— id: 173072, year: 2012, vol: 832, page: 151, stat: Journal Article,

Synthesis and Evaluation of a Selective Fluorogenic Pup Derived Assay Reagent for Dop, a Potential Drug Target in Mycobacterium tuberculosis
Merkx, Remco; Burns, Kristin E; Slobbe, Paul; El Oualid, Farid; El Atmioui, Dris; Darwin, K Heran; Ovaa, Huib
2012 Sep;13(14):2056-2060, Chembiochem : a European journal of chemical biology
— id: 179187, year: 2012, vol: 13, page: 2056, stat: Journal Article,

Copper in microbial pathogenesis: meddling with the metal
Samanovic, Marie I; Ding, Chen; Thiele, Dennis J; Darwin, K Heran
2012 Feb;11(2):106-115, Cell host & microbe
— id: 157483, year: 2012, vol: 11, page: 106, stat: Journal Article,

Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli
Cerda-Maira, Francisca A; McAllister, Fiona; Bode, Nadine J; Burns, Kristin E; Gygi, Steven P; Darwin, K Heran
2011 ;12(8):863-870, EMBO reports
— id: 135563, year: 2011, vol: 12, page: 863, stat: Journal Article,

A novel copper-responsive regulon in Mycobacterium tuberculosis
Festa, Richard A; Jones, Marcus B; Butler-Wu, Susan; Sinsimer, Daniel; Gerads, Russell; Bishai, William R; Peterson, Scott N; Darwin, K Heran
2011 Jan;79(1):133-148, Molecular microbiology
— id: 116213, year: 2011, vol: 79, page: 133, stat: Journal Article,

"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates
Burns, Kristin E; Cerda-Maira, Francisca A; Wang, Tao; Li, Huilin; Bishai, William R; Darwin, K Heran
2010 Sep 10;39(5):821-827, Molecular cell
— id: 138125, year: 2010, vol: 39, page: 821, stat: Journal Article,

Pupylation : A Signal for Proteasomal Degradation in Mycobacterium tuberculosis
Burns, Kristin E; Darwin, K Heran
2010 ;54:149-157, Sub-cellular biochemistry
— id: 119237, year: 2010, vol: 54, page: 149, stat: Journal Article,

Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation
Burns, Kristin E; Darwin, K Heran
2010 Apr 1;12(4):424-431, Cellular microbiology
— id: 109512, year: 2010, vol: 12, page: 424, stat: Journal Article,

Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates
Burns, Kristin E; Pearce, Michael J; Darwin, K Heran
2010 Jun;192(11):2933-2935, Journal of bacteriology
— id: 109670, year: 2010, vol: 192, page: 2933, stat: Journal Article,

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis
Cerda-Maira, Francisca A; Pearce, Michael J; Fuortes, Michele; Bishai, William R; Hubbard, Stevan R; Darwin, K Heran
2010 Sep;77(5):1123-1135, Molecular microbiology
— id: 114585, year: 2010, vol: 77, page: 1123, stat: Journal Article,

SAMPyling proteins in archaea
Darwin, K Heran; Hofmann, Kay
2010 Jun;35(6):348-351, Trends in biochemical sciences
— id: 110081, year: 2010, vol: 35, page: 348, stat: Journal Article,

Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis
Festa, Richard A; McAllister, Fiona; Pearce, Michael J; Mintseris, Julian; Burns, Kristin E; Gygi, Steven P; Darwin, K Heran
2010 ;5(1):e8589-e8589, PLoS one
— id: 106208, year: 2010, vol: 5, page: e8589, stat: Journal Article,

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation
Wang, Tao; Darwin, K Heran; Li, Huilin
2010 Nov;17(11):1352-1357, Nature structural & molecular biology
— id: 133840, year: 2010, vol: 17, page: 1352, stat: Journal Article,

The Mycobacterium tuberculosis Proteasome: More Than Just a Barrel-shaped Protease
Cerda-Maira, Francisca; Darwin, K Heran
2009 Dec;11(14-15):1150-1155, Microbes & infection
— id: 101566, year: 2009, vol: 11, page: 1150, stat: Journal Article,

Prokaryotic Ubiquitin-Like Protein Pup Is Intrinsically Disordered
Chen, Xiang; Solomon, William C; Kang, Yang; Cerda-Maira, Francisca; Darwin, K Heran; Walters, Kylie J
2009 Sep 11;392(1):208-217, Journal of molecular biology
— id: 101567, year: 2009, vol: 392, page: 208, stat: Journal Article,

Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis
Darwin, K Heran
2009 Jul;7(7):485-491, Nature reviews. Microbiology
— id: 100188, year: 2009, vol: 7, page: 485, stat: Journal Article,

Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa
Wang, Tao; Li, Hua; Lin, Gang; Tang, Chunyan; Li, Dongyang; Nathan, Carl; Darwin, K Heran; Li, Huilin
2009 Oct 14;17(10):1377-1385, Structure
— id: 112096, year: 2009, vol: 17, page: 1377, stat: Journal Article,

Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis
Pearce, Michael J; Mintseris, Julian; Ferreyra, Jessica; Gygi, Steven P; Darwin, K Heran
2008 Nov 14;322(5904):1104-1107, Science
— id: 93375, year: 2008, vol: 322, page: 1104, stat: Journal Article,

Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis
Festa, Richard A; Pearce, Michael J; Darwin, K Heran
2007 Apr;189(8):3044-3050, Journal of bacteriology
— id: 72728, year: 2007, vol: 189, page: 3044, stat: Journal Article,

Self-compartmentalized bacterial proteases and pathogenesis
Butler, Susan M; Festa, Richard A; Pearce, Michael J; Darwin, K Heran
2006 May;60(3):553-562, Molecular microbiology
— id: 64667, year: 2006, vol: 60, page: 553, stat: Journal Article,

Identification of substrates of the Mycobacterium tuberculosis proteasome
Pearce, Michael J; Arora, Pooja; Festa, Richard A; Butler-Wu, Susan M; Gokhale, Rajesh S; Darwin, K Heran
2006 Nov 15;25(22):5423-5432, EMBO journal
— id: 69696, year: 2006, vol: 25, page: 5423, stat: Journal Article,

Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue
Darwin, K Heran; Lin, Gang; Chen, Zhiqiang; Li, Huilin; Nathan, Carl F
2005 Jan;55(2):561-571, Molecular microbiology
— id: 56015, year: 2005, vol: 55, page: 561, stat: Journal Article,

Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis
Darwin, K Heran; Nathan, Carl F
2005 Aug;73(8):4581-4587, Infection & immunity
— id: 96290, year: 2005, vol: 73, page: 4581, stat: Journal Article,

A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP
Hisert, Katherine B; MacCoss, Michael; Shiloh, Michael U; Darwin, K Heran; Singh, Shaneen; Jones, Roger A; Ehrt, Sabine; Zhang, Zhaoying; Gaffney, Barbara L; Gandotra, Sheetal; Holden, David W; Murray, Diana; Nathan, Carl
2005 Jun;56(5):1234-1245, Molecular microbiology
— id: 96291, year: 2005, vol: 56, page: 1234, stat: Journal Article,

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide
Darwin, K Heran; Ehrt, Sabine; Gutierrez-Ramos, Jose-Carlos; Weich, Nadine; Nathan, Carl F
2003 Dec 12;302(5652):1963-1966, Science
— id: 45183, year: 2003, vol: 302, page: 1963, stat: Journal Article,

Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium
Darwin KH; Miller VL
2001 Apr 17;20(8):1850-1862, EMBO journal
— id: 45184, year: 2001, vol: 20, page: 1850, stat: Journal Article,

SigE is a chaperone for the Salmonella enterica serovar Typhimurium invasion protein SigD
Darwin KH; Robinson LS; Miller VL
2001 Feb;183(4):1452-1454, Journal of bacteriology
— id: 45185, year: 2001, vol: 183, page: 1452, stat: Journal Article,

The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes
Darwin KH; Miller VL
2000 Feb;35(4):949-960, Molecular microbiology
— id: 45186, year: 2000, vol: 35, page: 949, stat: Journal Article,

InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium
Darwin KH; Miller VL
1999 Aug;181(16):4949-4954, Journal of bacteriology
— id: 45187, year: 1999, vol: 181, page: 4949, stat: Journal Article,

Molecular basis of the interaction of Salmonella with the intestinal mucosa
Darwin KH; Miller VL
1999 Jul;12(3):405-428, Clinical microbiology reviews
— id: 45188, year: 1999, vol: 12, page: 405, stat: Journal Article,