Andrew J Darwin

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Andrew J Darwin, Ph.D.

Associate Professor;
Department of Microbiology (Microbiology )

Contact Info


550 First Avenue Floor 2 Room 202
Medical Science Building
New York, NY 10016-6481


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— University of Birmingham, Graduate Education
— Cornell University, PostDoctoral Training
— Washington University School of Medicine, PostDoctoral Training

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All data from NYU Health Sciences Library Faculty Bibliography — -


Regulation of bacterial virulence gene expression by cell envelope stress responses
Flores-Kim, Josue; Darwin, Andrew J
2014 Nov;5(8):835-851, Virulence
— id: 1440092, year: 2014, vol: 5, page: 835, stat: Journal Article,

Stress Relief during Host Infection: The Phage Shock Protein Response Supports Bacterial Virulence in Various Ways
Darwin, Andrew J
2013 Jul;9(7):e1003388-e1003388 e1003388, PLoS pathogens
— id: 438962, year: 2013, vol: 9, page: e1003388, stat: Journal Article,

The Pseudomonas aeruginosa Periplasmic Protease CtpA Can Affect Systems That Impact Its Ability To Mount Both Acute and Chronic Infections
Seo, Jin; Darwin, Andrew J
2013 Dec;81(12):4561-4570, Infection & immunity
— id: 626742, year: 2013, vol: 81, page: 4561, stat: Journal Article,

Changes in Psp protein binding partners, localization and behaviour upon activation of the Yersinia enterocolitica phage shock protein response
Yamaguchi, Saori; Reid, Dylan A; Rothenberg, Eli; Darwin, Andrew J
2013 Feb;87(3):656-671, Molecular microbiology
— id: 214012, year: 2013, vol: 87, page: 656, stat: Journal Article,

Links between type III secretion and extracytoplasmic stress responses in Yersinia
Flores-Kim, Josue; Darwin, Andrew J
2012 ;2:125-125, Frontiers in cellular & infection microbiology
— id: 180722, year: 2012, vol: 2, page: 125, stat: Journal Article,

Phage Shock Protein C (PspC) of Yersinia enterocolitica Is a Polytopic Membrane Protein with Implications for Regulation of the Psp Stress Response
Flores-Kim, Josue; Darwin, Andrew J
2012 Dec;194(23):6548-6559, Journal of bacteriology
— id: 180612, year: 2012, vol: 194, page: 6548, stat: Journal Article,

Phage shock proteins B and C prevent lethal cytoplasmic membrane permeability in Yersinia enterocolitica
Horstman, N Kaye; Darwin, Andrew J
2012 Aug;85(3):445-460, Molecular microbiology
— id: 174071, year: 2012, vol: 85, page: 445, stat: Journal Article,

Recent findings about the Yersinia enterocolitica phage shock protein response
Yamaguchi, Saori; Darwin, Andrew J
2012 Feb;50(1):1-7, Journal of microbiology (Seoul, Korea)
— id: 158283, year: 2012, vol: 50, page: 1, stat: Journal Article,

The Yersinia enterocolitica Phage Shock Proteins B and C Can Form Homodimers and Heterodimers In Vivo with the Possibility of Close Association between Multiple Domains
Gueguen, Erwan; Flores-Kim, Josue; Darwin, Andrew J
2011 Oct;193(20):5747-5758, Journal of bacteriology
— id: 137884, year: 2011, vol: 193, page: 5747, stat: Journal Article,

FtsH-Dependent Degradation of Phage Shock Protein C in Yersinia enterocolitica and Escherichia coli
Singh, Sindhoora; Darwin, Andrew J
2011 Dec;193(23):6436-6442, Journal of bacteriology
— id: 141071, year: 2011, vol: 193, page: 6436, stat: Journal Article,

Membrane association of PspA depends on activation of the phage-shock-protein response in Yersinia enterocolitica
Yamaguchi, Saori; Gueguen, Erwan; Horstman, N Kaye; Darwin, Andrew J
2010 Oct;78(2):429-443, Molecular microbiology
— id: 114061, year: 2010, vol: 78, page: 429, stat: Journal Article,

YtxR acts as an overriding transcriptional off switch for the Yersinia enterocolitica Ysc-Yop type 3 secretion system
Axler-DiPerte, Grace L; Hinchliffe, Stewart J; Wren, Brendan W; Darwin, Andrew J
2009 Jan;191(2):514-524, Journal of bacteriology
— id: 91979, year: 2009, vol: 191, page: 514, stat: Journal Article,

Analysis of the Yersinia enterocolitica PspBC proteins defines functional domains, essential amino acids and new roles within the phage-shock-protein response
Gueguen, Erwan; Savitzky, Diana C; Darwin, Andrew J
2009 Nov;74(3):619-633, Molecular microbiology
— id: 105336, year: 2009, vol: 74, page: 619, stat: Journal Article,

Analysis of secretin-induced stress in Pseudomonas aeruginosa suggests prevention rather than response and identifies a novel protein involved in secretin function
Seo, Jin; Brencic, Anja; Darwin, Andrew J
2009 Feb;191(3):898-908, Journal of bacteriology
— id: 92766, year: 2009, vol: 191, page: 898, stat: Journal Article,

Regulation of the phage-shock-protein stress response in Yersinia enterocolitica
Darwin, Andrew J
2007 ;603:167-177, Advances in experimental medicine & biology
— id: 74593, year: 2007, vol: 603, page: 167, stat: Journal Article,

Global analysis of tolerance to secretin-induced stress in Yersinia enterocolitica suggests that the phage-shock-protein system may be a remarkably self-contained stress response
Seo, Jin; Savitzky, Diana C; Ford, Emily; Darwin, Andrew J
2007 Aug;65(3):714-727, Molecular microbiology
— id: 73872, year: 2007, vol: 65, page: 714, stat: Journal Article,

YtxR, a conserved LysR-like regulator that induces the expression of genes encoding a putative ADP-ribosyltransferase toxin homologue in Yersinia enterocolitica
Axler-Diperte, Grace L; Miller, Virginia L; Darwin, Andrew J
2006 Dec;188(23):8033-8043, Journal of bacteriology
— id: 68762, year: 2006, vol: 188, page: 8033, stat: Journal Article,

Multiple promoters control expression of the Yersinia enterocolitica phage-shock-protein A (pspA) operon
Maxson, Michelle E; Darwin, Andrew J
2006 Apr;152(Pt 4):1001-1010, Microbiology (Reading, England)
— id: 66457, year: 2006, vol: 152, page: 1001, stat: Journal Article,

PspB and PspC of Yersinia enterocolitica are dual function proteins: regulators and effectors of the phage-shock-protein response
Maxson, Michelle E; Darwin, Andrew J
2006 Mar;59(5):1610-1623, Molecular microbiology
— id: 62401, year: 2006, vol: 59, page: 1610, stat: Journal Article,

Genome-wide screens to identify genes of human pathogenic Yersinia species that are expressed during host infection
Darwin, Andrew J
2005 Jul;7(2):135-149, Current issues in molecular biology
— id: 57669, year: 2005, vol: 7, page: 135, stat: Journal Article,

The phage-shock-protein response
Darwin, Andrew J
2005 Aug;57(3):621-628, Molecular microbiology
— id: 56310, year: 2005, vol: 57, page: 621, stat: Journal Article,

Improved system for construction and analysis of single-copy beta-galactosidase operon fusions in Yersinia enterocolitica
Maxson, Michelle E; Darwin, Andrew J
2005 Sep;71(9):5614-5618, Applied & environmental microbiology
— id: 58796, year: 2005, vol: 71, page: 5614, stat: Journal Article,

Identification of Yersinia genes expressed during host infection
Darwin AJ
Yersinia: Molecular and Cellular Biology Wymondham, Norfolk, U.K. : Horizon Bioscience, 2004,
— id: 3646, year: 2004, vol: , page: 149, stat: Chapter,

PspG, a New Member of the Yersinia enterocolitica Phage Shock Protein Regulon
Green, Rebecca C; Darwin, Andrew J
2004 Aug;186(15):4910-4920, Journal of bacteriology
— id: 43219, year: 2004, vol: 186, page: 4910, stat: Journal Article,

Identification of inducers of the Yersinia enterocolitica phage shock protein system and comparison to the regulation of the RpoE and Cpx extracytoplasmic stress responses
Maxson, Michelle E; Darwin, Andrew J
2004 Jul;186(13):4199-4208, Journal of bacteriology
— id: 43010, year: 2004, vol: 186, page: 4199, stat: Journal Article,

Periplasmic nitrate reductase (NapABC enzyme) supports anaerobic respiration by Escherichia coli K-12
Stewart, Valley; Lu, Yiran; Darwin, Andrew J
2002 Mar;184(5):1314-1323, Journal of bacteriology
— id: 27228, year: 2002, vol: 184, page: 1314, stat: Journal Article,

The psp locus of Yersinia enterocolitica is required for virulence and for growth in vitro when the Ysc type III secretion system is produced
Darwin AJ; Miller VL
2001 Jan;39(2):429-444, Molecular microbiology
— id: 20550, year: 2001, vol: 39, page: 429, stat: Journal Article,

Yersinia enterocolitica ClpB affects levels of invasin and motility
Badger JL; Young BM; Darwin AJ; Miller VL
2000 Oct;182(19):5563-5571, Journal of bacteriology
— id: 20551, year: 2000, vol: 182, page: 5563, stat: Journal Article,

Identification of Yersinia enterocolitica genes affecting survival in an animal host using signature-tagged transposon mutagenesis
Darwin AJ; Miller VL
1999 Apr;32(1):51-62, Molecular microbiology
— id: 20552, year: 1999, vol: 32, page: 51, stat: Journal Article,

Fnr, NarP, and NarL regulation of Escherichia coli K-12 napF (periplasmic nitrate reductase) operon transcription in vitro
Darwin AJ; Ziegelhoffer EC; Kiley PJ; Stewart V
1998 Aug;180(16):4192-4198, Journal of bacteriology
— id: 20553, year: 1998, vol: 180, page: 4192, stat: Journal Article,

Differential regulation by the homologous response regulators NarL and NarP of Escherichia coli K-12 depends on DNA binding site arrangement
Darwin AJ; Tyson KL; Busby SJ; Stewart V
1997 Aug;25(3):583-595, Molecular microbiology
— id: 20554, year: 1997, vol: 25, page: 583, stat: Journal Article,

Analysis of nitrate regulatory protein NarL-binding sites in the fdnG and narG operon control regions of Escherichia coli K-12
Darwin AJ; Li J; Stewart V
1996 May;20(3):621-632, Molecular microbiology
— id: 20555, year: 1996, vol: 20, page: 621, stat: Journal Article,

Expression of the narX, narL, narP, and narQ genes of Escherichia coli K-12: regulation of the regulators
Darwin AJ; Stewart V
1995 Jul;177(13):3865-3869, Journal of bacteriology
— id: 20557, year: 1995, vol: 177, page: 3865, stat: Journal Article,

Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site
Darwin AJ; Stewart V
1995 Aug 4;251(1):15-29, Journal of molecular biology
— id: 20556, year: 1995, vol: 251, page: 15, stat: Journal Article,

The NAR Modulon systems: nitrate and nitrite regulation of anaerobic gene expression
Darwin AJ; Stewart V
Regulation of gene expression in escherichia coli New York : Chapman & Hall; Austin TX: R.G. Landes, 1995,
— id: 2642, year: 1995, vol: , page: 343, stat: Chapter,

Regulation and sequence of the structural gene for cytochrome c552 from Escherichia coli: not a hexahaem but a 50 kDa tetrahaem nitrite reductase
Darwin A; Hussain H; Griffiths L; Grove J; Sambongi Y; Busby S; Cole J
1993 Sep;9(6):1255-1265, Molecular microbiology
— id: 23552, year: 1993, vol: 9, page: 1255, stat: Journal Article,

Identification of the formate dehydrogenases and genetic determinants of formate-dependent nitrite reduction by Escherichia coli K12
Darwin A; Tormay P; Page L; Griffiths L; Cole J
1993 Aug;139 ( Pt 8)(6):1829-1840, Journal of general microbiology
— id: 23553, year: 1993, vol: 139 ( Pt 8), page: 1829, stat: Journal Article,