Bruce Neil Cronstein

Biosketch / Results /

Bruce Neil Cronstein, M.D.

Professor; Dr. Paul R. Esserman Professor of Medicine; Director Program in Collaborative Research; Dir Division of Translational Medicine; Dir Clinical Translational Science Inst
Departments of Medicine (Clin Pharm Div), Pathology and Biochemistry and Molecular Pharmacology

Clinical Addresses

461 FIRST AVENUE, 16N1
NEW YORK, NY 10016
Phone: 212-263-6404

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Medical Specialties

Rheumatology, Internal Medicine

Dr. Cronstein is also a member of the Division of Rheumatology.

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Board Certification

1980 — Ab Internal Medicine - Internal Medicine
1984 — Ab Internal Medicine (Rheumatology)

Education

1977-1978 — NYU Medical Center (Pathology), Residency Training
1977-1978 — Bellevue Hospital Center (Pathology), Residency Training
1977-1978 — Department of Veterans Affairs-New York Campus (Pathology), Residency Training
1978-1980 — Lenox Hill Hospital (Medicine (Internal)), Residency Training
1980-1983 — NYU Medical Center, Clinical Fellowships
1980-1983 — Department of Veterans Affairs-New York Campus, Clinical Fellowships
1980-1983 — Bellevue Hospital Center, Clinical Fellowships

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Research Summary

Adenosine is released from most cells and tissues as a result of ATP catabolism in response to such stresses as hypoxia and inflammatory injury. Adenosine regulates numerous physiologic functions via interaction with one or more of at least four known receptors (A1, A2A, A2B, A3), all of which are members of the family of G protein-coupled receptors. At least one adenosine receptor type, and generally more than one type, is expressed on nearly every cell type and tissue examined. We first demonstrated the presence and function of both A1 and A2 adenosine receptors on human polymorphonuclear leukocytes and their critical role in regulating inflammation. In more recent studies we have shown that adenosine, acting at its receptors, mediates the antiinflammatory effects of methotrexate, the most commonly used drug in the treatment of Rheumatoid Arthritis. My laboratory continues to explore the mechanism by which adenosine receptors modulate cellular functions. Inflammation is a critical first step in dealing with tissue injury and for preventing superinfection at wounded sites. Because inflammation is the first step in wound healing we asked whether adenosine receptor agonists might promote wound healing. We have demonstrated that topical application of adenosine A2A receptor agonists stimulates more rapid wound healing, a phenomenon we have helped take into the clinic where an adenosine A2A receptor agonist is undergoing clinical trials for the promotion of healing of diabetic foot ulcers. We have explored the mechanism by which adenosine A2A receptor agonists promote wound healing and found that occupancy of A2A receptors by adenosine or its more selective and potent agonists promotes new blood vessel formation and new matrix formation by fibroblasts. Thus, adenosine A2A receptor agonists may be useful in stimulating wound healing. Because adenosine A2A receptor agonists stimulate more rapid and exuberant wound healing we determined whether adenosine A2A receptors were involved in scar formation although the scarring we examined was in the liver. We found that adenosine A2A receptors play a critical role in animal models of liver fibrosis and that agents that block these receptors could be used to block the development of liver cirrhosis/fibrosis, an important public health problem. Current research in the laboratory is focused on understanding the molecular mechanisms by which adenosine concentrations are increased in the extracellular space and how adenosine and its receptors regulate inflammation, wound healing and fibrosis.

Research Interests

Adenosine-mediated regulation of inflammation, wound healing, fibrosis and bone resorption and the pharmacology of adenosine receptors

Research Keywords

adenosine, adhesion, inflammation, neutrophil, wound healing<br><br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Activation of EPAC1/2 is essential for osteoclast formation by modulating NFkappaB nuclear translocation and actin cytoskeleton rearrangements
Mediero, Aranzazu; Perez-Aso, Miguel; Cronstein, Bruce N
2014 Nov;28(11):4901-4913, FASEB journal
— id: 1341742, year: 2014, vol: 28, page: 4901, stat: Journal Article,

Designing and Implementing INTREPID, an Intensive Program in Translational Research Methodologies for New Investigators
Plottel, Claudia S; Aphinyanaphongs, Yindalon; Shao, Yongzhao; Micoli, Keith J; Fang, Yixin; Goldberg, Judith D; Galeano, Claudia R; Stangel, Jessica H; Chavis-Keeling, Deborah; Hochman, Judith S; Cronstein, Bruce N; Pillinger, Michael H
2014 Jul;:1892-1897, Clinical & translational science
— id: 1089772, year: 2014, vol: , page: 1892, stat: Journal Article,

Mechanisms of action of methotrexate
Chan, Edwin S L; Cronstein, Bruce N
2013 ;71 Suppl 1:S5-S8, Bulletin of the Hospital for Joint Diseases (2013)
— id: 761472, year: 2013, vol: 71 Suppl 1, page: S5, stat: Journal Article,

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism
Chan, Edwin Sl; Liu, Hailing; Fernandez, Patricia; Luna, Alex; Perez-Aso, Miguel; Bujor, Andreea M; Trojanowska, Maria; Cronstein, Bruce N
2013 May;15(3):R58-R58 R58, Arthritis research & therapy
— id: 489912, year: 2013, vol: 15, page: R58, stat: Journal Article,

Colchicine Use and The Risk Of Myocardial Infarction Among Gout Patients: Interim Results From a VA Retrospective Cohort Study
Crittenden, Daria B. ; Kimmel, Jessica N. ; Pike, Virginia C. ; Diaz, Daniel ; Shah, Avni ; White, Cilian J. ; DeBerardine, Michael ; Kim, Grace ; Shah, Binita ; Swearingen, Christopher J. ; Greenberg, Jeffrey D. ; Sedlis, Steven P. ; Tenner, Craig T. ; Cronstein, Bruce N. ; Pillinger, Michael H.
2013 OCT;65 10 10(SI):S499-S499, Arthritis & rheumatism
— id: 657412, year: 2013, vol: 65 10 10, page: S499, stat: Journal Article,

Colchicine Use and The Risk Of Myocardial Infarction Among Gout Patients: Results From a Community-Based, Informatics-Driven Retrospective Cohort Study
Crittenden, Daria B. ; Shah, Binita ; Sedlis, Steven P. ; Swearingen, Christopher J. ; Wagner, Eric S. ; Henry, Yvette M. ; Berger, Peter B. ; Cronstein, Bruce N. ; Pillinger, Michael H.
2013 OCT;65 10 10(SI):S847-S847, Arthritis & rheumatism
— id: 656352, year: 2013, vol: 65 10 10, page: S847, stat: Journal Article,

Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis
Cronstein, Bruce N; Sunkureddi, Prashanth
2013 Jan;19(1):19-29, Journal of clinical rheumatology. JCR
— id: 213412, year: 2013, vol: 19, page: 19, stat: Journal Article,

Tenofovir But Not Adefovir Prevents Liver and Skin Fibrosis In Two Models Of Adenosine-Mediated Injury
Feig, Jessica L. ; Tivon, Doreen ; Aso, Miguel Perez ; Cardozo, Timothy ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S1096-S1097, Arthritis & rheumatism
— id: 657262, year: 2013, vol: 65 10 10, page: S1096, stat: Journal Article,

Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis
Fernandez, Patricia; Perez-Aso, Miguel; Smith, Gideon; Wilder, Tuere; Trzaska, Sean; Chiriboga, Luis; Franks, Andrew Jr; Robson, Simon C; Cronstein, Bruce N; Chan, Edwin S L
2013 Dec;183(6):1740-1746, American journal of pathology
— id: 652432, year: 2013, vol: 183, page: 1740, stat: Journal Article,

The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Ralpha) Signaling
Ferrante, Christopher James; Pinhal-Enfield, Grace; Elson, Genie; Cronstein, Bruce Neil; Hasko, Gyorgy; Outram, Shalini; Leibovich, Samuel Joseph
2013 Aug;36(4):921-931, Inflammation
— id: 489662, year: 2013, vol: 36, page: 921, stat: Journal Article,

Regulation of inflammation by adenosine
Hasko, Gyorgy; Cronstein, Bruce
2013 ;4:85-85, Frontiers in immunology
— id: 489922, year: 2013, vol: 4, page: 85, stat: Journal Article,

Rolofylline, an adenosine A(1) receptor antagonist, inhibits osteoclast differentiation as an inverse agonist
He, Wenjie ; Wilder, Tuere ; Cronstein, Bruce N.
2013 NOV;170(6):1167-1176, British journal of pharmacology
— id: 657082, year: 2013, vol: 170, page: 1167, stat: Journal Article,

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma
He, Wenjie; Mazumder, Amitabha; Wilder, Tuere; Cronstein, Bruce N
2013 May;:290-300, FASEB journal
— id: 489902, year: 2013, vol: , page: 290, stat: Journal Article,

Rolofylline, an Adenosine A Receptor Antagonist, Inhibits Osteoclast Differentiation as an Inverse Agonist
He, Wenjie; Wilder, Tuere; Cronstein, Bruce N
2013 Aug;:1740-1746, British journal of pharmacology
— id: 761502, year: 2013, vol: , page: 1740, stat: Journal Article,

The use of three-dimensionally printed beta-tricalcium phosphate/ hydroxyapatite to understand the regulation of adenosine receptors in osteoclast formation and promotion in bone regeneration
Ishack, S; Mediero, A; Wilder, T; Ricci, J; Cronstein, B N
2013 October 2013;65:S784-S785, Arthritis & rheumatism
— id: 819412, year: 2013, vol: 65, page: S784, stat: Journal Article,

The Use Of Three-Dimensionally Printed beta-Tricalcium Phosphate/Hydroxyapatite To Understand The Regulation Of Adenosine Receptors In Osteoclast Formation and Promotion In Bone Regeneration
Ishack, Stephanie ; Mediero, Aranzazu ; Wilder, Tuere ; Ricci, John ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S784-S785, Arthritis & rheumatism
— id: 656402, year: 2013, vol: 65 10 10, page: S784, stat: Journal Article,

NETRIN1 is a critical autocrine factor for osteoclast differentiation
Mediero, A; Ramkhelawon, B; Purdue, E; Goldring, S; Moore, K; Cronstein, B
2013 February 2013;28:-, Journal of bone & mineral research
— id: 1069612, year: 2013, vol: 28, page: , stat: Journal Article,

Adenosine A2A receptor as a potential new therapeutic target for the prevention/treatment of osteoarthritis
Mediero, A; Wilder, T; Cronstein, B N
2013 October 2013;65:S21-S21, Arthritis & rheumatism
— id: 819842, year: 2013, vol: 65, page: S21, stat: Journal Article,

Adenosine A2A receptor (A2AR) diminishes wear particle (UHMWPE)-mediated osteolysis, increases bone formation and regulates expression of axonal guidance proteins (AGP) by macrophages, osteoclasts (OC) and osteoblasts (OB)
Mediero, A; Wilder, T; Perez-Aso, M; Cronstein, B N
2013 October 2013;65:S781-S782, Arthritis & rheumatism
— id: 819422, year: 2013, vol: 65, page: S781, stat: Journal Article,

Netrin1 Is a Critical Autocrine Factor For Osteoclast Differentiation
Mediero, Aranzazu ; Ramkhelawon, Bhama ; Moore, Kathryn ; Purdue, P. Edward ; Goldring, Steven R. ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S1165-S1166, Arthritis & rheumatism
— id: 657212, year: 2013, vol: 65 10 10, page: S1165, stat: Journal Article,

Adenosine A(2A) Receptor As a Potential New Therapeutic Target For The Prevention/Treatment Of Osteoarthritis
Mediero, Aranzazu ; Wilder, Tuere ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S21-S21, Arthritis & rheumatism
— id: 657402, year: 2013, vol: 65 10 10, page: S21, stat: Journal Article,

Adenosine A(2A) Receptor (A2AR) Diminishes Wear Particle (UHMWPE)-Mediated Osteolysis, Increases Bone Formation and Regulates Expression Of Axonal Guidance Proteins (AGP) By Macrophages, Osteoclasts (OC) and Osteoblasts (OB)
Mediero, Aranzazu ; Wilder, Tuere ; Perez-Aso, Miguel ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S781-S782, Arthritis & rheumatism
— id: 657382, year: 2013, vol: 65 10 10, page: S781, stat: Journal Article,

Adenosine and bone metabolism
Mediero, Aranzazu; Cronstein, Bruce N
2013 Jun;24(6):290-300, Trends in endocrinology & metabolism
— id: 366782, year: 2013, vol: 24, page: 290, stat: Journal Article,

Activation of adenosine A2A receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFkappaB nuclear translocation
Mediero, Aranzazu; Perez-Aso, Miguel; Cronstein, Bruce N
2013 Jul;169(6):1372-1388, British journal of pharmacology
— id: 402162, year: 2013, vol: 169, page: 1372, stat: Journal Article,

An adenosine A2a receptor/HIF-1alpha axis sustains inflammasome activation resulting in liver injury and fibrosis that can be blocked by digoxin
Ouyang, X; Ghani, A; Malik, A F; Cronstein, B N; Mehal, W Z
2013 October 2013;58(4):338A-339A, Hepatology
— id: 670652, year: 2013, vol: 58, page: 338A, stat: Journal Article,

An adenosine A2a receptor/HIF-1 alpha axis Sustains Inflammasome Activation Resulting in Liver Injury and Fibrosis That Can Be Blocked by Digoxin
Ouyang, Xinshou; Ghani, Ayaz; Malik, Ahsan F.; Cronstein, Bruce N.; Mehal, Wajahat Z.
2013 OCT;58 1 1(SI):338A-339A, Hepatology
— id: 833502, year: 2013, vol: 58 1 1, page: 338A, stat: Journal Article,

Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1alpha pathway
Ouyang, Xinshou; Ghani, Ayaz; Malik, Ahsan; Wilder, Tuere; Colegio, Oscar Rene; Flavell, Richard Anthony; Cronstein, Bruce Neil; Mehal, Wajahat Zafar
2013 Dec;4:2909-2909, Nature communications
— id: 759752, year: 2013, vol: 4, page: 2909, stat: Journal Article,

PHARMACOLOGICAL BLOCKADE OF ADENOSINE A2A RECEPTORS (A2AR) PREVENTS RADIATION-INDUCED DERMAL INJURY
Perez-Aso, M.; Low, Y. C.; Ezeamuzie, O.; Levine, J.; Cronstein, B. N.
2013 SEP;113 1 1(SI):15-15, Basic & clinical pharmacology & toxicology
— id: 540772, year: 2013, vol: 113 1 1, page: 15, stat: Journal Article,

Adenosine A2A receptor activates the pro-fibrotic Wnt/beta-catenin signaling in human dermal fibroblasts
Perez-Aso, M; Cronstein, B N
2013 October 2013;65:S400-S400, Arthritis & rheumatism
— id: 819642, year: 2013, vol: 65, page: S400, stat: Journal Article,

Adenosine A2A receptor and TNF-alpha regulate the circadian machinery of the human monocytic THP-1 cells
Perez-Aso, M; Feig, J L; Mediero, A; Cronstein, B N
2013 Feb 2013;36(1):152-162, Inflammation
— id: 451682, year: 2013, vol: 36, page: 152, stat: Journal Article,

Adenosine A2A Receptor Activates The Pro-Fibrotic Wnt / beta-Catenin Signaling In Human Dermal Fibroblasts
Perez-Aso, Miguel ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S400-S400, Arthritis & rheumatism
— id: 657522, year: 2013, vol: 65 10 10, page: S400, stat: Journal Article,

Adenosine 2A Receptor Promotes Collagen Production By Human Fibroblasts Via Smad2/3-Independent Pathways Involving Cyclic AMP and AKT
Perez-Aso, Miguel ; Fernandez, Patricia ; Mediero, Aranzazu ; Chan, Edwin S. L. ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S790-S790, Arthritis & rheumatism
— id: 657292, year: 2013, vol: 65 10 10, page: S790, stat: Journal Article,

Adenosine A(2A) Receptor and TNF-alpha Regulate the Circadian Machinery of the Human Monocytic THP-1 Cells
Perez-Aso, Miguel; Feig, Jessica L; Aranzazu, Mediero; Cronstein, Bruce N
2013 Feb;36(1):152-162, Inflammation
— id: 213522, year: 2013, vol: 36, page: 152, stat: Journal Article,

Erratum to: Adenosine A(2A) Receptor and TNF-alpha Regulate the Circadian Machinery of the Human Monocytic THP-1 Cells
Perez-Aso, Miguel; Feig, Jessica L; Mediero, Aranzazu; Cronstein, Bruce N
2013 Feb;36(1):163-163, Inflammation
— id: 213552, year: 2013, vol: 36, page: 163, stat: Journal Article,

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3
Perez-Aso, Miguel; Fernandez, Patricia; Mediero, Aranzazu; Chan, Edwin S; Cronstein, Bruce N
2013 Nov;:1740-1746, FASEB journal
— id: 761482, year: 2013, vol: , page: 1740, stat: Journal Article,

Adenosine A2A receptor (AR) is a fine-tune regulator of the collagen1:collagen3 balance
Perez-Aso, Miguel; Mediero, Aranzazu; Cronstein, Bruce N
2013 Jun;:1372-1388, Purinergic signalling
— id: 489892, year: 2013, vol: , page: 1372, stat: Journal Article,

Adenosine A2A Receptors (A2AR) Promote Scarring By Repressing Mir-29a
Radusky, Ross C. ; Perez-Aso, Miguel ; Franks, Andrew G., Jr. ; Cronstein, Bruce N. ; Chan, Edwin S. L.
2013 OCT;65 10 10(SI):S790-S790, Arthritis & rheumatism
— id: 657302, year: 2013, vol: 65 10 10, page: S790, stat: Journal Article,

Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults
Rolita, Lydia; Spegman, Adele; Tang, Xiaoqin; Cronstein, Bruce N
2013 Mar;61(3):335-340, Journal of the American Geriatrics Society
— id: 288692, year: 2013, vol: 61, page: 335, stat: Journal Article,

Biosimilars: How Similar?
Strand, Vibeke; Cronstein, Bruce
2013 Oct;:1740-1746, Internal medicine journal
— id: 761492, year: 2013, vol: , page: 1740, stat: Journal Article,

Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate-resistant mice do not
You, Xin; Williams, Adrienne; Dervieux, Thierry; He, Wenjie; Cronstein, Bruce N
2013 May-Jun;31(3):433-435, Clinical & experimental rheumatology
— id: 422072, year: 2013, vol: 31, page: 433, stat: Journal Article,

Adenosine a2a receptor (a2ar) activation stimulates increased expression of collagen-1 and collagen-3 by different signaling pathways in normal human dermal fibroblasts
Aso, M P; Cronstein, B N
2012 October 2012;64:S759-S760, Arthritis & rheumatism
— id: 241672, year: 2012, vol: 64, page: S759, stat: Journal Article,

Pharmacological blockade of adenosine A2A receptors (A2AR) prevents radiation-induced dermal injury
Aso, M P; Low, Y C; Ezeamuzie, O; Levine, J; Cronstein, B N
2012 October 2012;64:S649-S649, Arthritis & rheumatism
— id: 241722, year: 2012, vol: 64, page: S649, stat: Journal Article,

Adenosine A2A Receptor (A(2A)R) Activation Stimulates Increased Expression of Collagen-1 and Collagen-3 by Different Signaling Pathways in Normal Human Dermal Fibroblasts
Aso, Miguel Perez; Cronstein, Bruce N.
2012 OCT;64(10 S S):S759-S760, Arthritis & rheumatism
— id: 184192, year: 2012, vol: 64, page: S759, stat: Journal Article,

Pharmacological Blockade of Adenosine A2A Receptors (A(2A)R) Prevents Radiation-Induced Dermal Injury
Aso, Miguel Perez; Low, Yee C.; Ezeamuzie, Obinna; Levine, Jamie; Cronstein, Bruce N.
2012 OCT;64(10 S S):S649-S649, Arthritis & rheumatism
— id: 183812, year: 2012, vol: 64, page: S649, stat: Journal Article,

Cholesterol 27-Hydroxylase but Not Apolipoprotein apoE Contributes to A(2A) Adenosine Receptor Stimulated Reverse Cholesterol Transport
Bingham TC; Parathath S; Tian H; Reiss A; Chan E; Fisher EA; Cronstein BN
2012 Feb;35(1):49-57, Inflammation
— id: 122556, year: 2012, vol: 35, page: 49, stat: Journal Article,

A public-private partnership: the new york university-health and hospitals corporation clinical and translational science institute
Capponi, Louis; Trinh-Shevrin, Chau; Cronstein, Bruce N; Hochman, Judith S
2012 Jun;5(3):223-225, Clinical & translational science
— id: 169518, year: 2012, vol: 5, page: 223, stat: Journal Article,

Colchicine Is Associated with a Decreased Rate of Myocardial Infarction in Gout Patients: Interim Results From a Retrospective Cohort Study
Crittenden, Daria B.; White, Cilian J.; DeBerardine, Michael; Kim, Grace; Shah, Binita; Kimmel, Jessica C.; Patel, Rima D.; Sedlis, Steven P.; Greenberg, Jeffrey D.; Tenner, Craig T.; Cronstein, Bruce N.; Pillinger, Michael H.
2012 OCT;64(10 S S):S71-S72, Arthritis & rheumatism
— id: 184292, year: 2012, vol: 64, page: S71, stat: Journal Article,

Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout
Crittenden, Daria B; Lehmann, R Aaron; Schneck, Laura; Keenan, Robert T; Shah, Binita; Greenberg, Jeffrey D; Cronstein, Bruce N; Sedlis, Steven P; Pillinger, Michael H
2012 Jul;39(7):1458-1464, Journal of rheumatology
— id: 171127, year: 2012, vol: 39, page: 1458, stat: Journal Article,

Tenofovir, a potent anti-viral agent, is an ecto-5'nucleotidase (CD73) inhibitor that prevents dermal fibrosis in a murine model of scleroderma
Feig, J L; Tivon, D; Perez-Aso, M; Cardozo, T; Cronstein, B N
2012 October 2012;64:S342-S342, Arthritis & rheumatism
— id: 241822, year: 2012, vol: 64, page: S342, stat: Journal Article,

Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5 ' Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma
Feig, Jessica L.; Tivon, Doreen; Perez-Aso, Miguel; Cardozo, Timothy; Cronstein, Bruce N.
2012 OCT;64(10 S S):S342-S342, Arthritis & rheumatism
— id: 183802, year: 2012, vol: 64, page: S342, stat: Journal Article,

Adenosine modulation of the pro-fibrogenic cytokine IL-13occurs viathe A2A adenosinereceptor
Franks, L; Radusky, R; Feig, J; Fernandez, P; Cronstein, B; Chan, E
2012 February 2012;51:i15-i15, Rheumatology (Oxford)
— id: 157715, year: 2012, vol: 51, page: i15, stat: Journal Article,

Adenosine A(1) receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling
He, W; Cronstein, B N
2012 Jun;8(2):327-337, Purinergic signalling
— id: 166814, year: 2012, vol: 8, page: 327, stat: Journal Article,

Adenosine regulates bone metabolism via A1, A2A and A2B receptors in bone marrow cells from normal and patients with multiple myeloma
He, W; Park, J; MazuMDer, A; Cronstein, B
2012 16 Nov 2012;:-, Blood
— id: 217102, year: 2012, vol: , page: , stat: Journal Article,

Rolofylline, an adenosine a r antagonist, inhibits osteoclast differentiation as an inverse agonist
He, W; Wilder, T; Cronstein, B
2012 2012;27:-, Journal of bone & mineral research
— id: 550542, year: 2012, vol: 27, page: , stat: Journal Article,

Rolofylline, an Adenosine A1R Antagonist, Acts As an Inverse Agonist to Inhibit Osteoclast Differentiation
He, Wenjie; Cronstein, Bruce N.
2012 OCT;64(10 S S):S833-S833, Arthritis & rheumatism
— id: 184232, year: 2012, vol: 64, page: S833, stat: Journal Article,

Adenosine Regulates Bone Metabolism Via A(1), A(2A) and A(2B) Receptors in Bone Marrow Cells From Normal and Patients with Multiple Myeloma
He, Wenjie; Mazumder, Amitabha; Cronstein, Bruce N.
2012 OCT;64(10 S S):S833-S833, Arthritis & rheumatism
— id: 183902, year: 2012, vol: 64, page: S833, stat: Journal Article,

Adenosine Regulates Bone Metabolism Via A(1), A(2A) and A(2B) Receptors in Bone Marrow Cells From Normal and Patients with Multiple Myeloma
He, Wenjie; Park, Jeesun; Mazumder, Amitabha; Cronstein, Bruce
2012 NOV 16;120(21):976-980, Blood
— id: 227322, year: 2012, vol: 120, page: 976, stat: Journal Article,

Adenosine a receptor stimulation inhibits osteoclast formation by suppressing NFKB translocation to the nucleus by a PKA-mediated mechanism
Mediero, A; Cronstein, B
2012 2012;27:-, Journal of bone & mineral research
— id: 550582, year: 2012, vol: 27, page: , stat: Journal Article,

Adenosine A2A receptor diminishes bone destruction at inflamed sites, in part, via downregulating semaphorin4d-plexinb1 communication between osteoclasts and osteoblasts
Mediero, A; Cronstein, B N
2012 October 2012;64:S6-S6, Arthritis & rheumatism
— id: 241982, year: 2012, vol: 64, page: S6, stat: Journal Article,

Adenosine a2a receptor stimulation inhibits oc formation by suppressing nfkb translocation to the nucleus by a PKA-ERK1/2 mediated mechanism
Mediero, A; Cronstein, B N
2012 October 2012;64:S6-S6, Arthritis & rheumatism
— id: 241992, year: 2012, vol: 64, page: S6, stat: Journal Article,

EPAC1 activation is required for NFB nuclear translocation and osteoclast differentiation
Mediero, A; Cronstein, B N
2012 October 2012;64:S5-S6, Arthritis & rheumatism
— id: 242002, year: 2012, vol: 64, page: S5, stat: Journal Article,

Targeting osteoclasts to promote bone regeneration; adenosine receptors regulate osteoclast formation and promote bone regeneration in a calvarial defect model
Mediero, A; Wilder, T; Cronstein, B
2012 2012;27:-, Journal of bone & mineral research
— id: 550532, year: 2012, vol: 27, page: , stat: Journal Article,

Adenosine A(2A) Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Mediero, Aranzazu; Cronstein, Bruce N.
2012 OCT;64(10 S S):S6-S6, Arthritis & rheumatism
— id: 184242, year: 2012, vol: 64, page: S6, stat: Journal Article,

Adenosine A(2A) Receptor Stimulation Inhibits OC Formation by Suppressing NFkB Translocation to the Nucleus by A PKA-ERK1/2 Mediated Mechanism
Mediero, Aranzazu; Cronstein, Bruce N.
2012 OCT;64(10 S S):S6-S6, Arthritis & rheumatism
— id: 184132, year: 2012, vol: 64, page: S6, stat: Journal Article,

EPAC1 Activation Is Required for NFkB Nuclear Translocation and Osteoclast Differentiation
Mediero, Aranzazu; Cronstein, Bruce N.
2012 OCT;64(10 S S):S5-S6, Arthritis & rheumatism
— id: 184112, year: 2012, vol: 64, page: S5, stat: Journal Article,

Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis
Mediero, Aranzazu; Frenkel, Sally R; Wilder, Tuere; He, Wenjie; Mazumder, Amitabha; Cronstein, Bruce N
2012 May;4(135):135ra65-135ra65 135ra65, Science translational medicine
— id: 167513, year: 2012, vol: 4, page: 135ra65, stat: Journal Article,

Adenosine A(2A) Receptor Ligation Inhibits Osteoclast Formation
Mediero, Aranzazu; Kara, Firas M; Wilder, Tuere; Cronstein, Bruce N
2012 Feb;180(2):775-786, American journal of pathology
— id: 150562, year: 2012, vol: 180, page: 775, stat: Journal Article,

Adenosine Receptors Stimulate Bone Regeneration by Targeting Osteoclasts
Mediero, Aranzazu; Wilder, Tuere; Cronstein, Bruce N.
2012 OCT;64(10 S S):S1062-S1062, Arthritis & rheumatism
— id: 183992, year: 2012, vol: 64, page: S1062, stat: Journal Article,

Adenosine A2A receptor (A2AR) activation stimulates increased expression of collagen-1 and collagen-3 by different signaling pathways in normal human dermal fibroblasts
Perez-Aso, M; Cronstein, B N
2012 April 2012;20(2):A34-A34, Wound repair & regeneration
— id: 162924, year: 2012, vol: 20, page: A34, stat: Journal Article,

Pharmacological blockade of adenosine A2A receptors (A2AR) diminishes scarring
Perez-Aso, M; Cronstein, B N
2012 April 2012;20(2):A34-A34, Wound repair & regeneration
— id: 162923, year: 2012, vol: 20, page: A34, stat: Journal Article,

Pharmacological blockade of adenosine A2A receptors diminishes scarring
Perez-Aso, Miguel; Chiriboga, Luis; Cronstein, Bruce N
2012 Oct;26(10):4254-4263, FASEB journal
— id: 179077, year: 2012, vol: 26, page: 4254, stat: Journal Article,

Adenosine A2A receptors promote wound healing by modulating miR-29a signaling
Radusky, R. C.; Cronstein, B. N.; Chan, E. S.; Perez-Aso, M.; Franks, A. G.
2012 SEP;132 2 2:S8-S8, Journal of investigative dermatology
— id: 177761, year: 2012, vol: 132 2 2, page: S8, stat: Journal Article,

The pro-fibrotic cytokines IL-33 and IL-13 modulate dermal fibrosis via the A2A adenosine receptor
Radusky, R. C.; Franks, L.; Feig, J.; Fernandez, P.; Franks, A. G.; Cronstein, B. N.; Chan, E. S.
2012 MAY;132:S10-S10, Journal of investigative dermatology
— id: 165684, year: 2012, vol: 132, page: S10, stat: Journal Article,

The Pro-Fibrotic Cytokines IL-33 and IL-13 Modulates Dermal Fibrosis Via the A2A Adenosine Receptor
Radusky, Ross C.; Feig, Jessica L.; Cronstein, Bruce N.; Franks, Andrew G.; Chan, Edwin S. L.
2012 OCT;64(10 S S):S768-S769, Arthritis & rheumatism
— id: 183952, year: 2012, vol: 64, page: S768, stat: Journal Article,

Regulation of foam cells by adenosine
Reiss, Allison B; Cronstein, Bruce N
2012 Apr;32(4):879-886, Arteriosclerosis, thrombosis, & vascular biology
— id: 162036, year: 2012, vol: 32, page: 879, stat: Journal Article,

Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS)
Shamoon, Harry; Center, David; Davis, Pamela; Tuchman, Mendel; Ginsberg, Henry; Califf, Robert; Stephens, David; Mellman, Thomas; Verbalis, Joseph; Nadler, Lee; Shekhar, Anantha; Ford, Daniel; Rizza, Robert; Shaker, Reza; Brady, Kathleen; Murphy, Barbara; Cronstein, Bruce; Hochman, Judith; Greenland, Philip; Orwoll, Eric; Sinoway, Lawrence; Greenberg, Harry; Jackson, Rebecca; Coller, Barry; Topol, Eric; Guay-Woodford, Lisa; Runge, Marschall; Clark, Robert; McClain, Don; Selker, Harry; Lowery, Curtis; Dubinett, Steven; Berglund, Lars; Cooper, Dan; Firestein, Gary; Johnston, S Clay; Solway, Julian; Heubi, James; Sokol, Ronald; Nelson, David; Tobacman, Larry; Rosenthal, Gary; Aaronson, Lauren; Barohn, Richard; Kern, Philip; Sullivan, John; Shanley, Thomas; Blazar, Bruce; Larson, Richard; FitzGerald, Garret; Reis, Steven; Pearson, Thomas; Buchanan, Thomas; McPherson, David; Brasier, Allan; Toto, Robert; Disis, Mary; Drezner, Marc; Bernard, Gordon; Clore, John; Evanoff, Bradley; Imperato-McGinley, Julianne; Sherwin, Robert; Pulley, Jill
2012 Apr;5(2):121-129, Clinical & translational science
— id: 386942, year: 2012, vol: 5, page: 121, stat: Journal Article,

Adenosine receptor signaling in keratinocyte proliferation and implications for caffeine and methotrexate therapy
Smith, Gideon; Franks, Andrew; Cronstein, Bruce; Chan, Edwin
2012 APR;66(4):AB34-AB34, Journal of the American Academy of Dermatology
— id: 165686, year: 2012, vol: 66, page: AB34, stat: Journal Article,

Adenosine-mediated dermal fibrosis and Fli-1 expression in CD39 and CD73 knockout mice
Smith, Gideon; Franks, Andrew; Cronstein, Bruce; Chan, Edwin; Liu, Hailing; Fernandez, Patricia
2012 APR;66(4):AB2-AB2, Journal of the American Academy of Dermatology
— id: 165685, year: 2012, vol: 66, page: AB2, stat: Journal Article,

The Effect of A(2A) Adenosine Receptor Activation on C-C Chemokine Receptor 7 Expression in Human THP1 Macrophages During Inflammation
Williams AJ; Cronstein BN
2012 Jul 8;:614-622 #, Inflammation
— id: 141440, year: 2012, vol: , page: 614, stat: Journal Article,

Adenosine-Mediated Dermal Fibrosis and Fli-1 Expression in CD39 and CD73 Knockout Mice
Chan, Edwin S. L.; Smith, Gideon; Fernandez, Patricia; Liu, Hailing; Franks, Andrew G.; Trojanowska, Maria; Cronstein, Bruce N.
2011 OCT;63(10):S907-S907, Arthritis & rheumatism
— id: 165688, year: 2011, vol: 63, page: S907, stat: Journal Article,

Biosimilars: the debate continues
Colbert, Robert A; Cronstein, Bruce N
2011 Oct;63(10):2848-2850, Arthritis & rheumatism
— id: 140486, year: 2011, vol: 63, page: 2848, stat: Journal Article,

Adenosine receptors and fibrosis: a translational review
Cronstein, Bruce N
2011 ;3:21-21, F1000 biology reports
— id: 139479, year: 2011, vol: 3, page: 21, stat: Journal Article,

Methylxanthines and inflammatory cells
Hasko, Gyorgy; Cronstein, Bruce
2011 ;(200):457-468, Handbook of experimental pharmacology
— id: 156271, year: 2011, vol: , page: 457, stat: Journal Article,

The roles of adenosine and adenosine receptors in bone remodeling
He, Wenjie; Cronstein, Bruce
2011 ;3:888-895, Frontiers in bioscience (Elite edition)
— id: 133467, year: 2011, vol: 3, page: 888, stat: Journal Article,

Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptor
Oliver, Stephen J; Mathew, Sneha; Wilder, Tuere F; Cronstein, Bruce N
2011 Mar;7(1):47-56, Purinergic signalling
— id: 130916, year: 2011, vol: 7, page: 47, stat: Journal Article,

Immune Responses Associated With Perioperative Exposure and Reexposure to Topical Bovine Thrombin Do Not Impair Hemostasis
Paterson CA; Pixton GC; Proskin HM; Massaro JM; Morasch M; Cronstein B; Fareed J; Ofosu FA
2011 Sep 7;:620-632, Clinical & applied thrombosis-hemostasis
— id: 141441, year: 2011, vol: , page: 620, stat: Journal Article,

Adenosine Receptor Signaling in Keratinocyte Proliferation and Implications for Caffeine and Methotrexate Therapy
Smith, Gideon; Franks, Andrew G.; Cronstein, Bruce N.; Chan, Edwin S. L.
2011 OCT;63(10):S206-S206, Arthritis & rheumatism
— id: 165687, year: 2011, vol: 63, page: S206, stat: Journal Article,

A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux
Bingham, Taiese Crystal; Fisher, Edward A; Parathath, Saj; Reiss, Allison B; Chan, Edwin S; Cronstein, Bruce N
2010 Apr;87(4):683-690, Journal of leukocyte biology
— id: 108919, year: 2010, vol: 87, page: 683, stat: Journal Article,

Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellate cells by STAT1-mediated repression of adenylyl cyclase
Block ET; Cronstein BN
2010 Oct;2010(2):113-126, International journal of interferon, cytokine & mediator research
— id: 138325, year: 2010, vol: 2010, page: 113, stat: Journal Article,

Adenosine in fibrosis
Chan, Edwin S L; Cronstein, Bruce N
2010 Apr;20(2):114-122, Modern rheumatology (Japan Rheumatism Association)
— id: 109055, year: 2010, vol: 20, page: 114, stat: Journal Article,

Methotrexate-how does it really work?
Chan, Edwin S L; Cronstein, Bruce N
2010 Mar;6(3):175-178, Nature reviews. Rheumatology
— id: 107789, year: 2010, vol: 6, page: 175, stat: Journal Article,

CD39/CD73 double knockout mice are protected against bleomycin-induced dermal fibrosis
Chan, Edwin; Fernandez, Patricia; Liu, Hailing; Robson, Simon; Cronstein, Bruce
2010 JUN ;6(6000):133-133, Purinergic signalling
— id: 113751, year: 2010, vol: 6, page: 133, stat: Journal Article,

How does methotrexate suppress inflammation?
Cronstein, B
2010 Sep-Oct;28(5 Suppl 61):S21-S23, Clinical & experimental rheumatology
— id: 114831, year: 2010, vol: 28, page: S21, stat: Journal Article,

Adenosine receptors and regulation of bone metabolism
Cronstein, Bruce
2010 JUN ;6(6000):22-22, Purinergic signalling
— id: 113749, year: 2010, vol: 6, page: 22, stat: Journal Article,

A personal journey from the joint to the heart
Cronstein, Bruce N
2010 ;12(4):134-134, Arthritis research & therapy
— id: 122558, year: 2010, vol: 12, page: 134, stat: Journal Article,

Caffeine, a drug for all seasons
Cronstein, Bruce N
2010 Jul;53(1):207-208, Journal of hepatology
— id: 110096, year: 2010, vol: 53, page: 207, stat: Journal Article,

Interest in conflicts
Cronstein, Bruce N
2010 Apr;3(2):52-53, Clinical & translational science
— id: 109563, year: 2010, vol: 3, page: 52, stat: Journal Article,

Drs. Fisher and Cronstein reply
Fisher, M; Cronstein, B
2010 ;37(5):1065-, Journal of rheumatology
— id: 569152, year: 2010, vol: 37, page: 1065, stat: Journal Article,

Race and Methotrexate Pharmacogenetics in Rheumatoid Arthritis reply
Fisher, M; Cronstein, B
2010 MAY ;37(5):1064-1064, Journal of rheumatology
— id: 109773, year: 2010, vol: 37, page: 1064, stat: Journal Article,

Adenosine A1 receptors regulates RANKL-induced osteoclast formation via regulation of c-fos and NFATc1 expression
He W.; Wilder T.; Cronstein B.N.
2010 ;62:1469-1469, Arthritis & rheumatism
— id: 130922, year: 2010, vol: 62, page: 1469, stat: Journal Article,

Adenosine A2A receptor activation protects CD4+T lymphocytes against activation-induced cell death
Himer, Leonora; Csoka, Balazs; Koscso, Balazs; Vizi, E. Sylvester; Cronstein, Bruce N.; Hasko, Gyorgy
2010 JUN ;6(6000):91-92, Purinergic signalling
— id: 113750, year: 2010, vol: 6, page: 91, stat: Journal Article,

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death
Himer, Leonora; Csoka, Balazs; Selmeczy, Zsolt; Koscso, Balazs; Pocza, Timea; Pacher, Pal; Nemeth, Zoltan H; Deitch, Edwin A; Vizi, E Sylvester; Cronstein, Bruce N; Hasko, Gyorgy
2010 Aug;24(8):2631-2640, FASEB journal
— id: 156272, year: 2010, vol: 24, page: 2631, stat: Journal Article,

Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function
Kara, Firas M; Chitu, Violeta; Sloane, Jennifer; Axelrod, Matthew; Fredholm, Bertil B; Stanley, E Richard; Cronstein, Bruce N
2010 Jul;24(7):2325-2333, FASEB journal
— id: 110659, year: 2010, vol: 24, page: 2325, stat: Journal Article,

Adenosine A(1) receptors regulate bone resorption in mice: Adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice
Kara, Firas M; Doty, Stephen B; Boskey, Adele; Goldring, Steven; Zaidi, Mone; Fredholm, Bertil B; Cronstein, Bruce N
2010 Feb;62(2):534-541, Arthritis & rheumatism
— id: 107269, year: 2010, vol: 62, page: 534, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating fli1 and CTGF expression
Liu H.; Chan E.; Fernandez P.; Cronstein B.N.
2010 ;62:600-600, Arthritis & rheumatism
— id: 130925, year: 2010, vol: 62, page: 600, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating Fli1 and CTGF expression
Liu, Hailing; Chan, Edwin; Fernandez, Patricia; Karuvelil, Rina; Cronstein, Bruce
2010 JUN ;6(6000):142-142, Purinergic signalling
— id: 113752, year: 2010, vol: 6, page: 142, stat: Journal Article,

Adenosine A2A receptor ligation inhibits osteoclast formation
Mediero A.; Kara F.M.; Hawly M.; Sellam E.; Cronstein B.N.
2010 ;62:1471-1471, Arthritis & rheumatism
— id: 130924, year: 2010, vol: 62, page: 1471, stat: Journal Article,

Adenosine A2A receptor agonists: can they prevent/treat joint prosthesis loosening?
Munoz, Aranzazu Mediero; Frenkel, Sally R.; Immerman, Igor; Hadley, Scott; Howell, Damani; Cronstein, Bruce N.
2010 JUN ;6(6000):159-160, Purinergic signalling
— id: 113753, year: 2010, vol: 6, page: 159, stat: Journal Article,

Immune Response Following Exposures to Topical Bovine Thrombin Does Not Impair Hemostasis
Paterson, Craig; Pixton, Glenn; Proskin, Howard; Massaro, Joseph; Morasch, Mark; Fareed, Jawed; Ofosu, Frederick; Cronstein, Bruce
2010 NOV 19 ;116(21):602-603, Blood
— id: 130852, year: 2010, vol: 116, page: 602, stat: Journal Article,

Methotrexate--the anchor drug--an introduction
Pincus, T; Cronstein, B; Braun, J
2010 Sep-Oct;28(5 Suppl 61):S1-S2, Clinical & experimental rheumatology
— id: 114830, year: 2010, vol: 28, page: S1, stat: Journal Article,

Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease
Reiss, Allison B; Anwar, Kamran; Merrill, Joan T; Chan, Edwin S L; Awadallah, Nahel W; Cronstein, Bruce N; Michael Belmont, H; Belilos, Elise; Rosenblum, Gary; Belostocki, Kristina; Bonetti, Lois; Hasneen, Kowser; Carsons, Steven E
2010 Mar;30(5):591-598, Rheumatology international
— id: 122562, year: 2010, vol: 30, page: 591, stat: Journal Article,

Production of adenosine by regulatory T cells through CD39 blocks adherence of effector T cells to vascular endothelium and thus abrogates contact hypersensitivity reactions
Ring, S; Oliver, S; Cronstein, B; Enk, A; Mahnke, K
2010 MAR ;6(1):95-95, Purinergic signalling
— id: 109828, year: 2010, vol: 6, page: 95, stat: Journal Article,

Cholesterol 27-hydroxylase but not apolipoprotein e contributes to A2A adenosine receptor enhanced reverse cholesterol transport
Bingham T.C.; Parahath S.; Reiss A.; Chan E.S.L.; Fisher E.; Cronstein B.N.
2009 ;60:433-433, Arthritis & rheumatism
— id: 130321, year: 2009, vol: 60, page: 433, stat: Journal Article,

Something old, something new - Colchicine in the 21st century
Cronstein, BN
2009 NOV ;10(11):1141-1142, Current opinion in investigational drugs
— id: 105232, year: 2009, vol: 10, page: 1141, stat: Journal Article,

Rheumatoid arthritis: GWAS or TMI?
Cronstein, Bruce N
2009 ;1(10):98-98, Genome medicine
— id: 105502, year: 2009, vol: 1, page: 98, stat: Journal Article,

Something old, something new--colchicine in the 21st century
Cronstein, Bruce N
2009 Nov;10(11):1141-1142, Current opinion in investigational drugs
— id: 122560, year: 2009, vol: 10, page: 1141, stat: Journal Article,

Adenosine receptors in wound healing, fibrosis and angiogenesis
Feoktistov, Igor; Biaggioni, Italo; Cronstein, Bruce N
2009 ;(193):383-397, Handbook of experimental pharmacology
— id: 122561, year: 2009, vol: , page: 383, stat: Journal Article,

Metaanalysis of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms Affecting Methotrexate Toxicity
Fisher, Mark C; Cronstein, Bruce N
2009 Mar;36(3):539-545, Journal of rheumatology
— id: 96257, year: 2009, vol: 36, page: 539, stat: Journal Article,

Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development
Katebi, Majid; Soleimani, Mansooreh; Cronstein, Bruce N
2009 Mar;85(3):438-444, Journal of leukocyte biology
— id: 96258, year: 2009, vol: 85, page: 438, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating IL-13 and Fli1 expression
Liu, HL; Fernandez, P; Trojanowska, M; Cronstein, BN; Edwin, S; Chan, L
2009 MAY-JUN ;27(3):S76-S76, Clinical & experimental rheumatology
— id: 104880, year: 2009, vol: 27, page: S76, stat: Journal Article,

Chronic fructose ingestion stimulates hepatic purine release and promotes the development of fatty liver
Peng Z.; Wilder T.; Williams A.; Cronstein B.N.
2009 ;60:1510-1510, Arthritis & rheumatism
— id: 130322, year: 2009, vol: 60, page: 1510, stat: Journal Article,

Adenosine signaling contributes to ethanol-induced fatty liver in mice
Peng, Zhongsheng; Borea, Pier Andrea; Varani, Katia; Wilder, Tuere; Yee, Herman; Chiriboga, Luis; Blackburn, Michael R; Azzena, Gianfranco; Resta, Giuseppe; Cronstein, Bruce N
2009 Mar;119(3):582-594, Journal of clinical investigation
— id: 156081, year: 2009, vol: 119, page: 582, stat: Journal Article,

A BRIEF COMMUNICATION: Enhanced CD36 Scavenger Receptor Expression in THP-1 Human Monocytes in the Presence of Lupus Plasma: Linking Autoimmunity and Atherosclerosis
Reiss, Allison B; Wan, David W; Anwar, Kamran; Merrill, Joan T; Wirkowski, Peter A; Shah, Nidhi; Cronstein, Bruce N; Chan, Edwin S L; Carsons, Steven E
2009 Mar;234(3):354-360, Experimental biology & medicine
— id: 94422, year: 2009, vol: 234, page: 354, stat: Journal Article,

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking adhesion of T cells to vascular endothelium via a CD39, adenosine-dependent mechanism
Ring S.; Oliver S.J.; Cronstein B.N.; Enk A.H.; Mahnke K.
2009 ;(129):S111-S111, Journal of investigative dermatology
— id: 131846, year: 2009, vol: , page: S111, stat: Journal Article,

Adenosine produced by CD4+CD25+regulatory T cells suppresses contact hypersensitivity reactions by engaging the A1 adenosine receptor on vascular endothelium
Ring, S; Oliver, S; Cronstein, B; Enk, AH; Mahnke, K
2009 SEP ;129(3):S1-S1, Journal of investigative dermatology
— id: 102141, year: 2009, vol: 129, page: S1, stat: Journal Article,

Production of adenosine by regulatory T cells through the ectonucleotidaseCD39 blocks adherence of effector T cell to vascular endothelium and thusabrogates contact hypersensitivity reactions
Ring, S; Oliver, S; Cronstein, B; Enk, AH; Mahnke, K
2009 MAR ;18(3):287-287, Experimental dermatology
— id: 93279, year: 2009, vol: 18, page: 287, stat: Journal Article,

CD4(+)CD25(+) regulatory T cells suppress contact hypersensitivity reactions by blocking adhesion of T cells to vascular endothelium via a CD39, adenosine-dependent mechanism
Ring, S; Oliver, SJ; Cronstein, BN; Enk, AH; Mahnke, K
2009 APR ;129(5):S111-S111, Journal of investigative dermatology
— id: 97876, year: 2009, vol: 129, page: S111, stat: Journal Article,

CD4(+)CD25(+) regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism
Ring, S; Oliver, SJ; Cronstein, BN; Enk, AH; Mahnke, K
2009 JUN ;123(6):1287-1296, Journal of allergy & clinical immunology
— id: 100449, year: 2009, vol: 123, page: 1287, stat: Journal Article,

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism
Ring, Sabine; Oliver, Stephen J; Cronstein, Bruce N; Enk, Alexander H; Mahnke, Karsten
2009 Jun;123(6):1287-96.e2, Journal of allergy & clinical immunology
— id: 122563, year: 2009, vol: 123, page: 1287, stat: Journal Article,

Adenosine receptor agonists for promotion of dermal wound healing
Valls, Maria D; Cronstein, Bruce N; Montesinos, M Carmen
2009 Apr 1;77(7):1117-1124, Biochemical pharmacology
— id: 96259, year: 2009, vol: 77, page: 1117, stat: Journal Article,

Modulation of Il-13 and Fli1 by adenosine - Implications for scleroderma
Chan, ES; Liu, H; Fernandez, P; Luna, A; Blackbum, M; Trojanowska, M; Cronstein, B
2008 SEP ;58(9):S833-S834, Arthritis & rheumatism
— id: 88573, year: 2008, vol: 58, page: S833, stat: Journal Article,

Immunomodulating pharmaceuticals
Chan, ESL; Oliver, SN; Cronstein, BN
Clinical Immunology St. Louis, Mo. : Mosby/Elsevier, 2008,
— id: 653312, year: 2008, vol: , page: 1331, stat: Chapter,

MEDI 28-Topical adenosine A2A receptor agonists for the treatment of poorly healing wounds
Cronstein, BN; Esserman, PR
2008 AUG 17 ;236(2):94-94, Abstracts of papers (American Chemical Society)
— id: 106240, year: 2008, vol: 236, page: 94, stat: Journal Article,

Bovine thrombin and the clinical consequence of antibody development
Cronstein, Bruce N
2008 Jan;206(1):199; author reply 199-199; author reply 200, Journal of the American College of Surgeons
— id: 96262, year: 2008, vol: 206, page: 199; author reply 199, stat: Journal Article,

Adenosine A(2A) receptor occupancy stimulates wound matrix production by modulating IL-13 and FLI1 expression
Fernandez, P; Luna, A; Trojanowska, M; Cronstein, BN; Chan, ESL
2008 MAR-APR ;16(2):A28-A28, Wound repair & regeneration
— id: 76411, year: 2008, vol: 16, page: A28, stat: Journal Article,

Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine
Fernandez, Patricia; Trzaska, Sean; Wilder, Tuere; Chiriboga, Luis; Blackburn, Michael R; Cronstein, Bruce N; Chan, Edwin S L
2008 Jun;172(6):1675-1682, American journal of pathology
— id: 79444, year: 2008, vol: 172, page: 1675, stat: Journal Article,

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Hasko, Gyorgy; Linden, Joel; Cronstein, Bruce; Pacher, Pal
2008 Sep;7(9):759-770, Nature reviews. Drug discovery
— id: 126434, year: 2008, vol: 7, page: 759, stat: Journal Article,

Adenosine and osteoporosis: Adenosine A1 receptor blockade reverses bone loss in ovariectomized mice and deletion of adenosine A2A receptors leads to diminished bone density
Kara, F; Doty, S; Boskey, A; Fredholm, B; Goldring, S; Zaidi, M; Cronstein, B
2008 MAY ;4(1):S173-S173, Purinergic signalling
— id: 86664, year: 2008, vol: 4, page: S173, stat: Journal Article,

Adenosine and osteoporosis: Adenosine A(2A) and A(2B) receptor blockade or deletion leads to diminished bone density
Kara, FM; Axelrod, M; Sloane, J; Doty, S; Boskey, A; Cronstein, BN
2008 SEP ;58(9):S648-S649, Arthritis & rheumatism
— id: 88559, year: 2008, vol: 58, page: S648, stat: Journal Article,

Role of adenosine A2A receptors in recruitment of fibrocytes (CD34+and collagen plus ) in a murine model of scleroderma
Katebi, M; Fernandez, P; Soleimani, M; Cronstein, B
2008 OCT ;53(1):393-393, Histopathology
— id: 91390, year: 2008, vol: 53, page: 393, stat: Journal Article,

Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis
Katebi, Majid; Fernandez, Patricia; Chan, Edwin S L; Cronstein, Bruce N
2008 Oct;31(5):299-303, Inflammation
— id: 93354, year: 2008, vol: 31, page: 299, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating II-13 and Fli1 expression
Liu, HL; Fernandez, P; Luna, A; Blackburn, M; Trojanowska, M; Cronstein, B; Chan, E
2008 MAY ;4(1):S63-S64, Purinergic signalling
— id: 86661, year: 2008, vol: 4, page: S63, stat: Journal Article,

Methotrexate (MTX), ethanol and the liver; Adenosine and its receptors play a central role 2 in fatty liver
Peng, Z; Wilder, T; Blackburn, MT; Fredholm, B; Cronstein, BN
2008 SEP ;58(9):S778-S778, Arthritis & rheumatism
— id: 88570, year: 2008, vol: 58, page: S778, stat: Journal Article,

Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
Peng, Zhongsheng; Fernandez, Patricia; Wilder, Tuere; Yee, Herman; Chiriboga, Luis; Chan, Edwin S L; Cronstein, Bruce N
2008 Jul;22(7):2263-2272, FASEB journal
— id: 79442, year: 2008, vol: 22, page: 2263, stat: Journal Article,

Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis
Peng, Zhongsheng; Fernandez, Patricia; Wilder, Tuere; Yee, Herman; Chiriboga, Luis; Chan, Edwin S L; Cronstein, Bruce N
2008 Jun;27(6):821-824, Nucleosides, nucleotides & nucleic acids
— id: 79449, year: 2008, vol: 27, page: 821, stat: Journal Article,

Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages
Reiss, Allison B; Carsons, Steven E; Anwar, Kamran; Rao, Soumya; Edelman, Sari D; Zhang, Hongwei; Fernandez, Patricia; Cronstein, Bruce N; Chan, Edwin S L
2008 Dec;58(12):3675-3683, Arthritis & rheumatism
— id: 94423, year: 2008, vol: 58, page: 3675, stat: Journal Article,

Liver X Receptors (LXRs) Mediate Adenosine-regulated Reverse Cholesterol Transport and Form Cell Formation
Tian, HH; Bingham, T; Cronstein, BN
2008 DEC ;58(12):3979-3979, Arthritis & rheumatism
— id: 91332, year: 2008, vol: 58, page: 3979, stat: Journal Article,

Contribution of annexin ii and plasminogen inhibitor-1 (PAI-1) in the proangiogenic effect of adenosine A2A receptor activation
Valls, MD; Williams, A; Cronstein, BN; Montesinos, MC
2008 MAY ;4(1):S119-S119, Purinergic signalling
— id: 86663, year: 2008, vol: 4, page: S119, stat: Journal Article,

Adenosine and its receptors play a central role in ethanol-induced fatty liver
Zhongsheng, P; Wilder, T; Blackburn, M; Fredholm, B; Cronstein, B
2008 MAY ;4(1):S82-S83, Purinergic signalling
— id: 86662, year: 2008, vol: 4, page: S82, stat: Journal Article,

Update on gout: pathophysiology and potential treatments
Abeles, Aryeh M; Park, Jean Y; Pillinger, Michael H; Cronstein, Bruce N
2007 Dec;11(6):440-446, Current pain & headache reports
— id: 96261, year: 2007, vol: 11, page: 440, stat: Journal Article,

Adenosine in inflammatory joint diseases
Chan, E S L; Fernandez, P; Cronstein, B N
2007 Mar;3(1-2):145-152, Purinergic signalling
— id: 105910, year: 2007, vol: 3, page: 145, stat: Journal Article,

Methotrexate in rheumatoid arthritis
Chan, Edwin Sl; Fernandez, Patricia; Cronstein, Bruce N
2007 Jan;3(1):27-33, Expert review of clinical immunology
— id: 110109, year: 2007, vol: 3, page: 27, stat: Journal Article,

Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway
Che, Jiantu; Chan, Edwin S L; Cronstein, Bruce N
2007 Dec;72(6):1626-1636, Molecular pharmacology
— id: 75450, year: 2007, vol: 72, page: 1626, stat: Journal Article,

Adenosine and inflammation
Cronstein B.N.
2007 ;7(4):280-285, Immunology, endocrine & metabolic agents in medicinal chemistry
— id: 74370, year: 2007, vol: 7, page: 280, stat: Journal Article,

Do elevated red blood cell methotrexate polyglutamate levels predict methotrexate efficacy?
Cronstein, Bruce N
2007 May;3(5):256-257, Nature clinical practice. Rheumatology
— id: 73850, year: 2007, vol: 3, page: 256, stat: Journal Article,

Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis
Cronstein, Bruce N
2007 ;65 Suppl 1:S11-S15, Bulletin of the NYU Hospital for Joint Diseases
— id: 74666, year: 2007, vol: 65 Suppl 1, page: S11, stat: Journal Article,

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls?
Cronstein, Bruce N; Kamen, Barton A
2007 Dec;29(12):805-807, Journal of pediatric hematology/oncology
— id: 75680, year: 2007, vol: 29, page: 805, stat: Journal Article,

Future treatment of rheumatic diseases: The role of pharmacogenetics
Fisher M.C.; Cronstein B.N.; Greenberg J.D.
2007 ;2(6):535-540, Future rheumatology
— id: 75700, year: 2007, vol: 2, page: 535, stat: Journal Article,

Meta-analysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity
Fisher, MC; Cronstein, BN
2007 DEC ;56(12):4283-4283, Arthritis & rheumatism
— id: 87213, year: 2007, vol: 56, page: 4283, stat: Journal Article,

Adenosine receptors : therapeutic aspects for inflammatory and immune diseases
Hasko, Gyorgy; Cronstein, Bruce N; Szabo, Csaba
Boca Raton FL : CRC/Taylor & Francis, 2007,
— id: 1599, year: 2007, vol: , page: , stat: ,

Requirements for T lymphocyte migration in explanted lymph nodes
Huang, Julie H; Cardenas-Navia, L Isabel; Caldwell, Charles C; Plumb, Troy J; Radu, Caius G; Rocha, Paulo N; Wilder, Tuere; Bromberg, Jonathan S; Cronstein, Bruce N; Sitkovsky, Michail; Dewhirst, Mark W; Dustin, Michael L
2007 Jun 15;178(12):7747-7755, Journal of immunology (1950)
— id: 73300, year: 2007, vol: 178, page: 7747, stat: Journal Article,

Adenosine and osteoporosis: Adenosine A(1) receptor blockade reverses bone loss in ovariectomized mice and deletion of adenosine A(2A) receptors leads to diminished bone density
Kara, FM; Doty, SB; Boskey, A; Fredholm, B; Cronstein, BN
2007 SEP ;22(1):S36-S36, Journal of bone & mineral research
— id: 75796, year: 2007, vol: 22, page: S36, stat: Journal Article,

Activation of adenosine receptors protects against type 1 diabetes
Mabley, JG; Nemeth, ZH; Bleich, D; Csoka, B; Pacher, P; Vizi, S; Deitch, EA; Szabo, C; Cronstein, BN; Hasko, G
2007 SEP ;50(9):S190-S190, Diabetologia
— id: 74150, year: 2007, vol: 50, page: S190, stat: Journal Article,

Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors
Macedo, Lisa; Pinhal-Enfield, Grace; Alshits, Vera; Elson, Genie; Cronstein, Bruce Neil; Leibovich, Samuel Joseph
2007 Dec;171(6):1774-1788, American journal of pathology
— id: 126435, year: 2007, vol: 171, page: 1774, stat: Journal Article,

Neutrophils (Polymorphonuclear Leukocytes) in Systemic Lupus Erythematosus
Molad, Y; Cronstein, B
Systemic Lupus Erythematosus Philadelphia : Mosby Elsevier, c2007,
— id: 644372, year: 2007, vol: , page: 281, stat: Chapter,

The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice
Montesinos, M Carmen; Takedachi, Masahide; Thompson, Linda F; Wilder, Tuere F; Fernandez, Patricia; Cronstein, Bruce N
2007 May;56(5):1440-1445, Arthritis & rheumatism
— id: 96263, year: 2007, vol: 56, page: 1440, stat: Journal Article,

Adenosine receptor activation ameliorates type 1 diabetes
Nemeth, Zoltan H; Bleich, David; Csoka, Balazs; Pacher, Pal; Mabley, Jon G; Himer, Leonora; Vizi, E Sylvester; Deitch, Edwin A; Szabo, Csaba; Cronstein, Bruce N; Hasko, Gyorgy
2007 Aug;21(10):2379-2388, FASEB journal
— id: 73890, year: 2007, vol: 21, page: 2379, stat: Journal Article,

Adenosine receptors, wound healing, and angiogenesis
Sheth, Aneesh; Cronstein, Bruce
Adenosine receptors : therapeutic aspects for inflammatory and immune diseases Boca Raton FL : CRC/Taylor & Francis, 2007,
— id: 4824, year: 2007, vol: , page: ?, stat: Chapter,

Adenosine and osteoporosis: Deletion of adenosine A2A receptors leads to diminished bone density
Sloane, J; Kara, FM; Axelrod, M; Doty, SB; Boskey, A; Cronstein, BN
2007 DEC ;56(12):4243-4243, Arthritis & rheumatism
— id: 87210, year: 2007, vol: 56, page: 4243, stat: Journal Article,

Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis
Tian, Henghe; Cronstein, Bruce N
2007 ;65(3):168-173, Bulletin of the NYU Hospital for Joint Diseases
— id: 75659, year: 2007, vol: 65, page: 168, stat: Journal Article,

Adenosine 5 '-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
Bours, MJL; Swennen, ELR; Di Virgilio, F; Cronstein, BN; Dagnelie, PC
2006 NOV ;112(2):358-404, Pharmacology & therapeutics
— id: 69186, year: 2006, vol: 112, page: 358, stat: Journal Article,

Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
Chan, E S L; Fernandez, P; Merchant, A A; Montesinos, M C; Trzaska, S; Desai, A; Tung, C F; Khoa, D N; Pillinger, M H; Reiss, A B; Tomic-Canic, M; Chen, J F; Schwarzschild, M A; Cronstein, B N
2006 Aug;54(8):2632-2642, Arthritis & rheumatism
— id: 68662, year: 2006, vol: 54, page: 2632, stat: Journal Article,

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
Chan, Edwin S L; Montesinos, Maria Carmen; Fernandez, Patricia; Desai, Avani; Delano, David L; Yee, Herman; Reiss, Allison B; Pillinger, Michael H; Chen, Jiang-Fan; Schwarzschild, Michael A; Friedman, Scott L; Cronstein, Bruce N
2006 Aug;148(8):1144-1155, British journal of pharmacology
— id: 66126, year: 2006, vol: 148, page: 1144, stat: Journal Article,

Adenosine A(2A) receptors and dermal fibrosis: a pathogenic role for adenosine in diffuse dermal fibrosis
Chan, ESL; Fernandez, P; Merchant, AA; Desai, A; Montesinos, MC; Tung, CF; Khoa, DN; Pillinger, MH; Reiss, AB; Tomic-Canic, M; Chen, JF; Schwarzschild, MA; Cronstein, BN
2006 SEP ;11(1):144-144, Journal of investigative dermatology symposium proceedings
— id: 76164, year: 2006, vol: 11, page: 144, stat: Journal Article,

Going with the flow: methotrexate, adenosine, and blood flow
Cronstein, BN
2006 APR ;65(4):421-422, Annals of rheumatic diseases
— id: 63788, year: 2006, vol: 65, page: 421, stat: Journal Article,

Adenosine receptors and wound healing, revised
Cronstein, Bruce M
2006 ;6:984-991, ScientificWorldJournal
— id: 69492, year: 2006, vol: 6, page: 984, stat: Journal Article,

Do genetic variations in the adenosine pathway affect patient response to methotrexate?
Cronstein, Bruce N
2006 Dec;2(12):648-649, Nature clinical practice. Rheumatology
— id: 111678, year: 2006, vol: 2, page: 648, stat: Journal Article,

Pharmacogenetics in the rheumatic diseases
Cronstein, Bruce N
2006 ;64(1-2):16-19, Bulletin of the NYU Hospital for Joint Diseases
— id: 69491, year: 2006, vol: 64, page: 16, stat: Journal Article,

Pharmacogenetics in the rheumatic diseases, from pret-a-porter to haute couture
Cronstein, Bruce N
2006 Jan;2(1):2-3, Nature clinical practice. Rheumatology
— id: 68937, year: 2006, vol: 2, page: 2, stat: Journal Article,

The inflammatory process of gout and its treatment
Cronstein, Bruce N; Terkeltaub, Robert
2006 ;8 Suppl 1:S3-S3, Arthritis research & therapy
— id: 66701, year: 2006, vol: 8 Suppl 1, page: S3, stat: Journal Article,

Adenosine modulation in vivo - Implications for dermal fibrogenesis in seleroderma
Fernandez, P; Trzaska, SM; Wilder, T; Fernandez, M; Blackburn, MR; Cronstein, BN; Chan, ESL
2006 SEP ;54(9):S726-S727, Arthritis & rheumatism
— id: 70134, year: 2006, vol: 54, page: S726, stat: Journal Article,

Adenosine A(1) receptors (A(1)R) play a critical role in osteoclast formation
Kara, FM; Doty, SB; Boskey, A; Fredholm, B; Cronstein, BN
2006 SEP ;54(9):S511-S512, Arthritis & rheumatism
— id: 70123, year: 2006, vol: 54, page: S511, stat: Journal Article,

Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane
Khoa, Nguyen D; Postow, Michael; Danielsson, Jennifer; Cronstein, Bruce N
2006 Apr;69(4):1311-1319, Molecular pharmacology
— id: 64581, year: 2006, vol: 69, page: 1311, stat: Journal Article,

The adenosine system remodels Toll-like receptor 2-mediated innate immunity in the human newborn
Levy, O; Coughlin, M; Roy, RM; Cronstein, BN; Wessels, MR
2006 APR 1 ;176(4):S71-S72, Journal of immunology (1950)
— id: 68837, year: 2006, vol: 176, page: S71, stat: Journal Article,

The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn
Levy, Ofer; Coughlin, Melissa; Cronstein, Bruce N; Roy, Rene M; Desai, Avani; Wessels, Michael R
2006 Aug 1;177(3):1956-1966, Journal of immunology (1950)
— id: 69493, year: 2006, vol: 177, page: 1956, stat: Journal Article,

Conflict of interest
MacKenzie, C Ronald; Cronstein, Bruce N
2006 Sep;2(2):198-201, HSS journal : the musculoskeletal journal of Hospital for Special Surgery
— id: 96260, year: 2006, vol: 2, page: 198, stat: Journal Article,

Augmentation of cutaneous hypersensitivity by acute perceived stress is mediated by the adenosine a1 receptor
Mathew, S; Wilder, T; Cronstein, BN; Oliver, SJ
2006 SEP ;54(9):S95-S95, Arthritis & rheumatism
— id: 70105, year: 2006, vol: 54, page: S95, stat: Journal Article,

Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis
Montesinos, M Carmen; Desai, Avani; Cronstein, Bruce N
2006 ;8(2):R53-R53, Arthritis research & therapy
— id: 69494, year: 2006, vol: 8, page: R53, stat: Journal Article,

TNF-alpha prevents desensitization of G alpha s-coupled receptors (Adenosine and beta-adrenergic receptors) by inhibiting G protein-coupled receptor kinase 2 (GRK2) association with the plasma membrane via a sphingolipid/JNK pathway
Nguyen, KD; Postow, M; Danielsson, J; Cronstein, BN
2006 SEP ;54(9):S640-S640, Arthritis & rheumatism
— id: 70129, year: 2006, vol: 54, page: S640, stat: Journal Article,

Atherogenic properties of lupus plasma: Increased foam cell transformation and CD36 scavenger receptor and diminished cholesterol 27-hydroxylase
Reiss, AB; Wan, DW; Merrill, JT; Zhang, HW; Chan, ESL; Rao, S; Belilos, E; Bonetti, L; Rosenblum, G; Belostocki, K; Belmont, HM; Cronstein, BN; Carsons, S
2006 SEP ;54(9):S460-S460, Arthritis & rheumatism
— id: 70122, year: 2006, vol: 54, page: S460, stat: Journal Article,

COX-2 inhibitor-mediated disruption of cholesterol transport is abrogated by addition of prostaglandin D-2 or E-2: Anti-atherogenicity of a functional prostaglandin system
Reiss, AB; Zhang, HW; Edelman, SD; Fernandez, P; Cronstein, BN; Pillinger, MH; Ragolia, L; Carsons, S; Chan, ESL
2006 SEP ;54(9):S403-S404, Arthritis & rheumatism
— id: 70118, year: 2006, vol: 54, page: S403, stat: Journal Article,

Proteins involved in the parthogenesis of atherosclerosis, 2006
Reiss, Allison B; Carsons, Steven E; Cronstein, Bruce N
Trivandrum, Kerala, India : Research Signpost, 2006,
— id: 1602, year: 2006, vol: , page: , stat: ,

A prize for the foreign-born
Vilcek, Jan; Cronstein, Bruce N
2006 Jul;20(9):1281-1283, FASEB journal
— id: 66700, year: 2006, vol: 20, page: 1281, stat: Journal Article,

Cox-2-selective inhibitors interfere with cholesterol transport: A possible mechanism for atherogenic effects
Chan, ESL; Zhang, HW; Fernandez, P; Cronstein, BN; Pillinger, MH; Ragolia, L; Carsons, S; Reiss, AB
2005 SEP ;52(9):S354-S354, Arthritis & rheumatism
— id: 59279, year: 2005, vol: 52, page: S354, stat: Journal Article,

A common genetic variant of methylene tetrahydrofolate reductase (MTHFR) is associated with protection from development of hepatic fibrosis in patients treated with methotrexate for psoriasis
Cronstein, BN; Liu, H; Zachariae, H; Delano, D
2005 SEP ;52(9):S351-S351, Arthritis & rheumatism
— id: 59278, year: 2005, vol: 52, page: S351, stat: Journal Article,

Response to RFP: "rigorous test of intelligent design"
Cronstein, Bruce
2005 Dec;19(14):1936-1937, FASEB journal
— id: 62639, year: 2005, vol: 19, page: 1936, stat: Journal Article,

Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al
Cronstein, Bruce N
2005 Apr;52(4):1338-9; author reply 1339, Arthritis & rheumatism
— id: 69495, year: 2005, vol: 52, page: 1338, stat: Journal Article,

Gout: forgotten therapy for a common disease
Cronstein, Bruce N
2005 Mar;7(1):1-2, Current rheumatology reports
— id: 69496, year: 2005, vol: 7, page: 1, stat: Journal Article,

An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation
Delano, David L; Montesinos, M Carmen; D'Eustachio, Peter; Wiltshire, Tim; Cronstein, Bruce N
2005 Feb;29(1):1-7, Inflammation
— id: 64161, year: 2005, vol: 29, page: 1, stat: Journal Article,

Adenosine A(2A) receptor (A(2A)R) mediates dermal fibrosis in scleroderma
Fernandez, P; Montesinos, C; Desai, A; Pillinger, MH; Reiss, AB; Cronstein, BN; Chan, ESL
2005 SEP ;52(9):S364-S364, Arthritis & rheumatism
— id: 59280, year: 2005, vol: 52, page: S364, stat: Journal Article,

Adenosine receptor activation modulates interlukin-10 and TNF-alpha secretion in thioglycollate-induced peritoneal inflammation
Montesinos, C; Desai, A; Cronstein, BN
2005 SEP ;52(9):S470-S471, Arthritis & rheumatism
— id: 59287, year: 2005, vol: 52, page: S470, stat: Journal Article,

Nucleoside triphosphate dephorphorylase (CD39), adenosine A(1) and A(2A) receptors influence gramdomatous responses to mycobacterium bovis BCG
Mor, A; Kishimoto, M; Cronstein, BN
2005 SEP ;52(9):S99-S100, Arthritis & rheumatism
— id: 59271, year: 2005, vol: 52, page: S99, stat: Journal Article,

TNF-alpha prevents desensitization of gas-coupled receptors by regulating G protein-coupled receptor kinase 2 (GRK2) and beta-arrestin association with the plasma membrane - A potential explanation for anti-TNF-alpha-mediated exacerbation of congestive heart failure (CHF)?
Nguyen, KD; Postow, M; Cronstein, BN
2005 SEP ;52(9):S270-S270, Arthritis & rheumatism
— id: 59275, year: 2005, vol: 52, page: S270, stat: Journal Article,

Immunology for the rheumatologist
Cronstein, Bruce N
Philadelphia : Saunders, 2004,
— id: 1601, year: 2004, vol: , page: , stat: ,

Inmunologia para reumatologos = Immunology for the rheumatologist
Cronstein, Bruce N; Andreu, Jose Luis; Ahearn, Joseph M
Madrid : Panamericana, 2004,
— id: 1603, year: 2004, vol: , page: , stat: ,

Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages
Reiss, Allison B; Patel, Chirag A; Rahman, Mohammad M; Chan, Edwin S L; Hasneen, Kowser; Montesinos, Maria C; Trachman, Julie D; Cronstein, Bruce N
2004 Nov;10(11):BR420-BR425, Medical science monitor
— id: 69497, year: 2004, vol: 10, page: BR420, stat: Journal Article,

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
Montesinos, M Carmen; Desai, Avani; Delano, Dave; Chen, Jiang-Fan; Fink, J Stephen; Jacobson, Marlene A; Cronstein, Bruce N
2003 Jan;48(1):240-247, Arthritis & rheumatism
— id: 34759, year: 2003, vol: 48, page: 240, stat: Journal Article,

Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
Nguyen, D Khoa; Montesinos, M Carmen; Williams, Adrienne J; Kelly, Maureen; Cronstein, Bruce N
2003 Oct 15;171(8):3991-3998, Journal of immunology (1950)
— id: 39041, year: 2003, vol: 171, page: 3991, stat: Journal Article,

Molecular action of methotrexate in inflammatory diseases
Chan, Edwin S L; Cronstein, Bruce N
2002 ;4(4):266-273, Arthritis research
— id: 34760, year: 2002, vol: 4, page: 266, stat: Journal Article,

Methotrexate-induced hepatic fibrosis: Adenosine A(2A) receptor is responsible for hepatic collagen production in vivo and protective effect of caffeine
Chan, ESL; Delano, DL; Montesinos, C; Pillinger, ML; Reiss, AB; Friedman, SL; Cronstein, BN
2002 SEP ;46(9):S546-S547, Arthritis & rheumatism
— id: 37123, year: 2002, vol: 46, page: S546, stat: Journal Article,

TH1 Cytokines regulate adenosine receptor number and function in human microvascular endothelial cells
Khoa, ND; Montesinos, MC; Reiss, AB; Williams, AJ; Cronstein, BN
2002 SEP ;46(9):S400-S400, Arthritis & rheumatism
— id: 37122, year: 2002, vol: 46, page: S400, stat: Journal Article,

Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin
Leibovich, Samuel Joseph; Chen, Jiang-Fan; Pinhal-Enfield, Grace; Belem, Paula C; Elson, Genie; Rosania, Anthony; Ramanathan, Madhuri; Montesinos, Carmen; Jacobson, Marlene; Schwarzschild, Michael A; Fink, J Stephen; Cronstein, Bruce
2002 Jun;160(6):2231-2244, American journal of pathology
— id: 69498, year: 2002, vol: 160, page: 2231, stat: Journal Article,

Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A(2A) Receptors
Montesinos, M Carmen; Desai, Avani; Chen, Jiang-Fan; Yee, Herman; Schwarzschild, Michael A; Fink, J Stephen; Cronstein, Bruce N
2002 Jun;160(6):2009-2018, American journal of pathology
— id: 27826, year: 2002, vol: 160, page: 2009, stat: Journal Article,

Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel)
Victor-Vega, Cassandre; Desai, Avani; Montesinos, M Carmen; Cronstein, Bruce N
2002 Feb;26(1):19-24, Inflammation
— id: 27827, year: 2002, vol: 26, page: 19, stat: Journal Article,

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells
Khoa ND; Montesinos MC; Reiss AB; Delano D; Awadallah N; Cronstein BN
2001 Oct 1;167(7):4026-4032, Journal of immunology (1950)
— id: 26616, year: 2001, vol: 167, page: 4026, stat: Journal Article,

Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages
Reiss AB; Awadallah NW; Malhotra S; Montesinos MC; Chan ES; Javitt NB; Cronstein BN
2001 Nov;42(11):1913-1922, Journal of lipid research
— id: 26514, year: 2001, vol: 42, page: 1913, stat: Journal Article,

Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis
Montesinos MC; Yap JS; Desai A; Posadas I; McCrary CT; Cronstein BN
2000 Mar;43(3):656-663, Arthritis & rheumatism
— id: 9813, year: 2000, vol: 43, page: 656, stat: Journal Article,

Colchicine
Molad, Yair; Cronstein, Bruce; Malawista, Stephen E.
Gout, hyperuricemia, and other crystal-associated arthropathies New York : M. Dekker, 1999,
— id: 4823, year: 1999, vol: , page: ?, stat: Chapter,

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides
Morabito L; Montesinos MC; Schreibman DM; Balter L; Thompson LF; Resta R; Carlin G; Huie MA; Cronstein BN
1998 Jan 15;101(2):295-300, Journal of clinical investigation
— id: 7697, year: 1998, vol: 101, page: 295, stat: Journal Article,

Inhibition of methotrexate-induced rheumatoid nodulosis by colchicine: Evidence from an in vitro model and regression in 7 of 14 patients
Merrill, JT; Cronstein, BN; Mitnick, H; Goodman, S; Diakolios, C; Paget, S; Greisman, S; Bauer, B; Dinu, A; Shen, C; Lahita, RG
1997 ;3(6):328-333, Journal of clinical rheumatology. JCR
— id: 589422, year: 1997, vol: 3, page: 328, stat: Journal Article,

CLINICAL USE OF METHYLPREDNISOLONE SODIUM SUCCINATE - A REVIEW
CRONSTEIN, BN
1995 JAN ;56(1):1-15, Current therapeutic research
— id: 87458, year: 1995, vol: 56, page: 1, stat: Journal Article,

THE ANTIINFLAMMATORY ACTION OF SULFASALAZINE (SSA) IS MEDIATED BY ADENOSINE(ADO)
GADANGI, P; LONGAKER, M; NAIME, D; CARLIN, G; CRONSTEIN, BN
1995 SEP ;38(9):1308-1308, Arthritis & rheumatism
— id: 86700, year: 1995, vol: 38, page: 1308, stat: Journal Article,

Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1
Lozada C; Levin RI; Huie M; Hirschhorn R; Naime D; Whitlow M; Recht PA; Golden B; Cronstein BN
1995 Aug 29;92(18):8378-8382, Proceedings of the National Academy of Sciences of the United States of America
— id: 7927, year: 1995, vol: 92, page: 8378, stat: Journal Article,

MECHANISMS OF RHEUMATOID NODULOSIS - METHOTREXATE-ENHANCED MONOCYTE FUSION REQUIRES PROTEIN-SYNTHESIS AND INTACT MICROTUBLES
MERRILL, JT; COFFEY, D; SHEN, C; ZAKHARENKO, O; ZHANG, HW; LAHITA, RG; CRONSTEIN, BN
1995 SEP ;38(9):25-25, Arthritis & rheumatism
— id: 86684, year: 1995, vol: 38, page: 25, stat: Journal Article,

SIGNAL-TRANSDUCTION PIT NEUTROPHIL (PMN) ADENOSINE (ADO) A(2A) RECEPTORS - ACTIVATION OF A PLASMA MEMBRANE-ASSOCIATED PROTEIN PHOSPHATASE
REVAN, S; MONTESINOS, C; NAIME, D; CRONSTEIN, BN
1995 SEP ;38(9):234-234, Arthritis & rheumatism
— id: 86689, year: 1995, vol: 38, page: 234, stat: Journal Article,

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
Cronstein BN; Naime D; Ostad E
1993 Dec;92(6):2675-2682, Journal of clinical investigation
— id: 6346, year: 1993, vol: 92, page: 2675, stat: Journal Article,

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1
Cronstein BN; Kimmel SC; Levin RI; Martiniuk F; Weissmann G
1992 Nov 1;89(21):9991-9995, Proceedings of the National Academy of Sciences of the United States of America
— id: 9824, year: 1992, vol: 89, page: 9991, stat: Journal Article,

Correlation of the conformation of a modified ribonuclease octapeptide, homologous to peptide T, with its ability to induce CD4-dependent monocyte chemotaxis
Licht, D; Cronstein, B; Dykes, D C; Pedersen, J; Luster, S M; Trampota, M; Hull, E; Friedman, F K; Pincus, M R
1992 Oct;11(5):475-481, Journal