David Eric Cohen, M.P.H., M.D.

Multiple epidermotropic cutaneous melanoma metastases
Contreras, M; Kopf, A; Cohen, D; Polsky, D; Terushkin, V
2010 MAR ;62(3):AB101-AB101, Journal of the American Academy of Dermatology
— id: 110144, year: 2010, vol: 62, page: AB101, stat: Journal Article,

Analysis of the benign to malignant ratio of lesions biopsied by a general dermatologist before and after the adoption of dermoscopy
Terushkin, Vitaly; Warycha, Melanie; Levy, Marla; Kopf, Alfred W; Cohen, David E; Polsky, David
2010 Mar;146(3):343-344, Archives of dermatology
— id: 108435, year: 2010, vol: 146, page: 343, stat: Journal Article,

A 20-year analysis of previous and emerging allergens that elicit photoallergic contact dermatitis
Victor, Frank C; Cohen, David E; Soter, Nicholas A
2010 Apr;62(4):605-610, Journal of the American Academy of Dermatology
BACKGROUND: Retrospective chart reviews are periodically needed to update allergen series to detect changes in photoallergic contact dermatitis (PACD) over time. OBJECTIVE: We sought to evaluate photopatch test results during a 13-year period and extend the observations to 20 years. METHODS: A retrospective chart review was conducted in patients who were photopatch tested. RESULTS: In all, 76 patients were evaluated. A total of 69 positive photopatch and 45 positive patch test reactions were detected in 30 and 23 patients, respectively. The frequencies of the positive photopatch test reactions were sunscreens 23.2%, antimicrobial agents 23.2%, medications 20.3%, fragrances 13%, plants and plant derivatives 11.6%, and pesticides 8.7%. Of the positive photopatch reactions to antimicrobial agents, 60% were caused by Fentichlor. LIMITATIONS: This study was a retrospective chart analysis, and the number of patients was small. CONCLUSIONS: Sunscreens and antimicrobial agents were the most frequent allergens eliciting PACD, and there was a decrease in PACD caused by fragrances. The number of reactions to medications increased. This study also demonstrated that pesticides can be a cause of PACD. The detection of reactions to Fentichlor was unexpected and, although they have been attributed in some studies to cross-reactions to sulfanilamides and bithionol, such a robust association was not observed in this study. This study extends our experience of the changes in the allergens that elicit PACD to 20 years
— id: 108792, year: 2010, vol: 62, page: 605, stat: Journal Article,

Generalized eruptive keratoacanthomas of Grzybowski
Lu, Phoebe D; Lee, Arnold; Cassetty, Christopher T; Cheung, Wang; Wang, Nadia; Halpern, Allan C; Cohen, David E
2009 ;15(8):6-6, Dermatology online journal
A 48-year-old man presented with a two-year history of a generalized, pruritic eruption that was associated with numerous, dome-shaped papules and nodulocystic lesions. Biopsy specimens have shown keratoacanthomas and a lichenoid dermatitis. Evaluation for malignant conditions has been negative. Owing to the constellation of findings, a diagnosis of generalized eruptive keratoacanthomas of Grzybowski associated with lichenoid dermatitis and acneiform lesions is favored. The patient is currently on a trial of acitretin
— id: 105697, year: 2009, vol: 15, page: 6, stat: Journal Article,

Contact leukoderma from para-phenylenediamine
Saitta, Peter; Cohen, David; Brancaccio, Ronald
2009 Jan-Feb;20(1):56-57, Dermatitis
— id: 135235, year: 2009, vol: 20, page: 56, stat: Journal Article,

Identification of the constituents of balsam of peru in tomatoes
Srivastava, Divya; Cohen, David E
2009 Mar-Apr;20(2):99-105, Dermatitis
BACKGROUND: Studies show that balsam-restricted diets result in significant improvement of systemic contact dermatitis in patients with contact allergy to balsam of Peru (BOP). While tomatoes have been implicated as a frequent cause of BOP-related dermatitis, the presence of BOP in tomatoes has never been confirmed. OBJECTIVES: High-performance liquid chromatography coupled with mass spectrometry (liquid chromatography [LC]-MS) and UV spectrometry (LC-UV) was used to detect the possible presence of BOP constituents in tomatoes. METHODS: Samples of beefsteak, cherry, and plum tomatoes were extracted in ethyl acetate and analyzed with LC-MS and LC-UV for the presence of the following sensitizing constituents of BOP: benzoic acid, benzyl alcohol, trans-cinnamic acid, cinnamic alcohol, cinnamyl cinnamate, coniferyl alcohol, eugenol, isoeugenol, and methyl cinnamate. RESULTS: The initial LC-MS analysis of each tomato extract showed multiple peaks. Two of these peaks had molecular weights of 134 and 180, which correspond to cinnamic alcohol and coniferyl alcohol, respectively. The analysis did not show peaks corresponding to the molecular weights of the remaining compounds. Cochromatography of tomato extract with cinnamic alcohol and coniferyl alcohol using LC-UV further suggested the presence of these compounds in the tomato extract. CONCLUSION: Coniferyl alcohol and cinnamic alcohol, constituents of BOP, are present in beefsteak, cherry, and plum tomatoes
— id: 98904, year: 2009, vol: 20, page: 99, stat: Journal Article,

A series of critically challenging case scenarios in moderate to severe psoriasis: a Delphi consensus approach
Strober, Bruce; Berger, Emily; Cather, Jennifer; Cohen, David; Crowley, Jeffrey J; Gordon, Kenneth B; Gottlieb, Alice; Horn, Elizabeth J; Kavanaugh, Arthur F; Korman, Neal J; Krueger, Gerald G; Leonardi, Craig L; Menter, Alan; Schwartzman, Sergio; Sobell, Jeffrey M; Young, Melodie
2009 Jul;61(1 Suppl 1):S1-S46, Journal of the American Academy of Dermatology
Clinical trials for systemic psoriasis therapy typically enroll healthy patients and exclude patients with cardiovascular disease, latent tuberculosis, liver disease, histories of malignancies, viral infections, children, and pregnant or breast-feeding women. Physicians often require guidance for optimum management of severe psoriasis in patients that have a combination of underlying disease states. To provide treatment recommendations for complex psoriasis scenarios, a consensus panel comprising 15 experts in psoriatic disease convened to review and discuss available evidence-based data and to arrive at a consensus for treatment options of difficult cases. An application of the Delphi Method was used to select case scenarios, provide medical treatment options, present the case study with existing medical evidence, and anonymously vote on treatment options. The top 10 treatment options were ranked and statistically analyzed to compare the differences between treatments. The final rankings and analysis provide guidance for practical, safe, and efficacious treatment options in a number of complex psoriasis scenarios
— id: 100196, year: 2009, vol: 61, page: S1, stat: Journal Article,

Chronic actinic dermatitis
Booth, Alexandria V; Mengden, Stephanie; Soter, Nicholas A; Cohen, David
2008 ;14(5):25-25, Dermatology online journal
A 71-year-old man presented with a six-year history of a pruritic, erythematous, blistering eruption of the face, chest, and arms. Clinical findings, histopathologic features, and phototests were consistent with a diagnosis of chronic actinic dermatitis. The patient also had contact allergy and photocontact allergy to multiple allergens. A discussion of chronic actinic dermatitis is presented
— id: 94816, year: 2008, vol: 14, page: 25, stat: Journal Article,

Use of the North American Contact Dermatitis Group Standard 65-allergen series alone in the evaluation of allergic contact dermatitis: a series of 794 patients
Cohen, David E; Rao, Shaline; Brancaccio, Ronald R
2008 May-Jun;19(3):137-141, Dermatitis
BACKGROUND: The 'gold standard' for diagnosing allergic contact dermatitis is patch testing. Previous studies have not adequately addressed the validity and usefulness of the North American Contact Dermatitis Group (NACDG) Standard 65-allergen series alone as a screening tool in the evaluation of contact dermatitis. OBJECTIVE: The purpose of this study is to examine the usefulness of the NACDG series of 65 allergens as an exclusive screening method in the diagnosis of contact allergy. METHODS: A retrospective chart review of 794 patients referred for patch testing with the NACDG Screening Series with or without additional allergens was performed to determine the number of positive patch-test results. The study groups were analyzed to identify whether the positive reactions were to allergens in the NACDG Standard Series or to allergens in the supplementary group. RESULTS: Of the 794 patients patch-tested between July 1, 2004, and July 1, 2006, 590 (74.31%) had a positive reaction to either an NACDG patch-tested allergen or a supplemental allergen; 386 (65.42%) patients testing positive for an allergen were positive to an NACDG allergen only, and 534 (90.51%) of the total positive reactors were positive for at least one NACDG test allergen. CONCLUSION: As a screening tool, the NACDG Standard Series is substantially more efficacious than are more limited standard series when used exclusively in the evaluation of patients with allergic contact dermatitis. More extensive testing, including testing with suspected supplementary allergens determined by thorough history and physical examination, can improve upon the NACDG series as a means to investigate the full causes of contact dermatitis in any individual patient
— id: 86652, year: 2008, vol: 19, page: 137, stat: Journal Article,

Hereditary papulotranslucent acrokeratoderma
Rizzo, Carina; Bragg, Jennifer; Soldano, Anthony C; Cohen, David; Soter, Nicholas A
2008 ;14(5):3-3, Dermatology online journal
A 79-year-old woman presented with a history of peeling of the palms and soles that began in young adulthood, with exacerbation after exposure to water. Her mother, 2 sisters, and a female maternal cousin have similar symptoms. Physical examination showed scale and hyperlinearity of the palms. Brief exposure to water initiated the development of 1-to 2-mm, translucent, white papules that were distributed diffusely on the palmar surface, with a concentration at the palmar margins and pressure points. Histopathologic examination showed an acanthotic epidermis with a central depression that was filled with compact orthokeratosis. The physical examination and histopathologic findings are consistent with a diagnosis of hereditary papulotranslucent acrokeratoderma
— id: 94817, year: 2008, vol: 14, page: 3, stat: Journal Article,

Lichen aureus
Hazan, Carole; Fangman, Bill; Cohen, David
2007 ;13(1):23-23, Dermatology online journal
— id: 150305, year: 2007, vol: 13, page: 23, stat: Journal Article,

Cutaneous reactions to injectable corticosteroids
Amin, Nilam; Brancaccio, Ronald; Cohen, David
2006 Sep;17(3):143-146, Dermatitis
Corticosteroids are used to treat a variety of medical conditions. While topical preparations are known to commonly cause allergic contact dermatits, systemic use of these drugs rarely causes cutaneous reactions. (This paper presents) Two cases of (systemic) injectable corticosteroid use resulting in delayed hypersensitivity reactions are presented
— id: 93622, year: 2006, vol: 17, page: 143, stat: Journal Article,

Contact dermatitis: a practice parameter
Beltrani, VS; Bernstein, IL; Cohen, DE; Fonacier, L
2006 SEP ;97(3):S1-S38, Annals of allergy, asthma & immunology
— id: 68791, year: 2006, vol: 97, page: S1, stat: Journal Article,

Hypersensitivity reactions to vaccine components
Heidary, Noushin; Cohen, David E
2005 Sep;16(3):115-120, Dermatitis
Vaccines are responsible for the control of many infectious diseases that were once common in the United States, including polio, measles, diphtheria, pertussis (whooping cough), rubella (German measles), mumps, tetanus, and Haemophilus influenzae type b. National efforts to generate collaboration between federal, state, and local governments and public and private health care providers have resulted in record high levels of vaccination coverage in the United States. The high rate of US vaccinations is paralleled by growing concerns about the safety of their delivery. The variety of substances used in vaccines sometimes causes the development of cutaneous reactions in susceptible adults and children. This article will review adverse cutaneous events consistent with hypersensitivity reactions to the following ingredients in vaccines: aluminum, thimerosal, 2-phenoxyethanol, formaldehyde, and neomycin
— id: 63734, year: 2005, vol: 16, page: 115, stat: Journal Article,

Dermatologic surgical implications of allergic contact dermatitis
Jacob, SE; Amado, A; Cohen, DE
2005 SEP ;31(9):1116-1123, Dermatologic surgery
BACKGROUND. Dermatologic surgery is a common practice among dermatologists; consequently, there is an increased number of exposures to potential contact allergens in the surgical setting. OBJECTIVE. The purpose of this article is to alert the clinician to the most common allergens associated with the use of surgical products. CONCLUSIONS. Increased awareness will lead to early diagnosis and allergen avoidance
— id: 57881, year: 2005, vol: 31, page: 1116, stat: Journal Article,

Performance of a rapid dermatology referral system during the anthrax outbreak
Redd, John T; Van Beneden, Chris; Soter, Nicholas A; Hatzimemos, Eric; Cohen, David E
2005 Jun;52(6):1077-1081, Journal of the American Academy of Dermatology
The bioterrorism-related anthrax outbreak generated unanticipated demand for dermatologic services. In this study we sought to perform rapid, efficient, cost-effective evaluation of patients suspected of having cutaneous anthrax. During the outbreak, we developed an anthrax evaluation system featuring clinical field examination by nondermatologist physicians, followed by rapid referral of selected high-risk patients to a centralized dermatology center. We excluded anthrax in 29 previously screened high-risk patients. All were examined within 24 hours, costing $272.07 per patient. Diagnoses were established quickly (median, same day; range, 0-15 days). Among 2259 at-risk postal workers, 144 (6.4%) self-identified new (< or =14 days) skin lesions and were examined in the field; 8 (5.6%) were referred to our system. Our system was not the only local dermatologic resource available during the outbreak. A system featuring initial nondermatologist examination with minimal laboratory evaluation, followed by rapid centralized referral of high-risk patients, functioned efficiently in this outbreak
— id: 67942, year: 2005, vol: 52, page: 1077, stat: Journal Article,

Infantile granular parakeratosis: recognition of two clinical patterns
Chang, Mary Wu; Kaufmann, Julie M; Orlow, Seth J; Cohen, David E; Mobini, Narciss; Kamino, Hideko
2004 May;50(5 Suppl):S93-S96, Journal of the American Academy of Dermatology
Granular parakeratosis is an acquired, idiopathic disorder of keratinization typified by retention hyperkeratosis. It usually occurs in women at intertriginous sites. There have been only 2 reports of infants with granular parakeratosis to our knowledge. We describe 3 additional infants with granular parakeratosis. We demonstrate that infantile granular parakeratosis exhibits 2 clinical patterns: bilateral linear plaques in the inguinal folds; and erythematous geometric plaques underlying pressure points from the diaper. A thick, flakelike scale is present in both forms and is characteristic. Diaper wearing appears to play an important role in the genesis of infantile granular parakeratosis but the mechanisms are unclear. Therapeutic responsiveness to topical agents is ambiguous, however, spontaneous clearance after months to 1 year appears to be the rule
— id: 44892, year: 2004, vol: 50, page: S93, stat: Journal Article,

Contact dermatitis: a quarter century perspective
Cohen, David E
2004 Aug;51(1 Suppl):S60-S63, Journal of the American Academy of Dermatology
— id: 46009, year: 2004, vol: 51, page: S60, stat: Journal Article,

Treatment of irritant and allergic contact dermatitis
Cohen, David E; Heidary, Noushin
2004 ;17(4):334-340, Dermatologic therapy
The treatment of contact dermatitis lies principally in the avoidance of the offending agent. In certain circumstances, avoidance protocols are insurmountable, and therapy is rendered to assuage the inflammatory component and its consequent objective and subjective findings. However, the options thereafter vary, as some patients will require continuous symptomatic therapy despite avoidance of the purported offending agent. This manuscript will review established treatment options for contact dermatitis, such as corticosteroids and dietary manipulation, as well as discuss some promising new therapies from the last decade, such as the immunomodulatory and anti-inflammatory agents
— id: 47805, year: 2004, vol: 17, page: 334, stat: Journal Article,

Dermatomyositis
Gruson, Lisa M; Cohen, David E
2004 ;10(3):7-7, Dermatology online journal
A 51-year-old woman presented with weakness in her arms and legs and an eruption on the dorsal aspects of the hands, upper back, and face. Histopathologic features showed vacuolar alteration of the basal layer, a thick basement membrane, and deposits of connective-tissue mucin in the papillary dermis and the upper reticular dermis. Dermatomyositis is an idiopathic disease that is characterized by specific cutaneous manifestations and myopathy, which may be associated with occult malignancy. Treatment options include corticosteroids and other immunosuppressive agents such as methotrexate, cyclosporine, mycophenolate mofetil, and azathioprine
— id: 56008, year: 2004, vol: 10, page: 7, stat: Journal Article,

Granulomatous cheilitis
Kovich, Olympia I; Cohen, David E
2004 ;10(3):10-10, Dermatology online journal
A 54-year-old man presented with lip swelling, which was not altered by a trial of medication discontinuation. Patch tests showed reactions to bromonitropropane and gold, which were not clinically relevant. Treatment included topical and intralesional glucorticoids as well as tacrolimus ointment. Granulomatous chelitis an idiopathic disorder that is characterized by painless lip edema. It may be found as part of the triad of Melkersson-Rosenthal syndrome. Treatment includes intralesional glucocorticoids as well as systemic therapies
— id: 56007, year: 2004, vol: 10, page: 10, stat: Journal Article,

Cowden's syndrome
Kovich, Olympia; Cohen, David
2004 ;10(3):3-3, Dermatology online journal
A 59-year-old woman initially presented with facial papules, which were consistent with trichilemmomas on histopathologic examination. Her course was complicated by breast, endometrial, and renal-cell carcinomas, as well as a multinodular goiter that necessitated a thyroidectomy. Cowden's syndrome is a rare autosomal dominant syndrome that is characterized by hamartomas of ectodermal, mesodermal, and endodermal origin as well as an increased risk of breast, thyroid, and endometrial neoplasias. Medical management includes screening for breast cancer and thyroid abnormalities, and performing other age-specific examinations. Treatment of facial papules includes topical 5-fluorouracil, isotretinoin, curettage, laser ablation, or surgical excision
— id: 66028, year: 2004, vol: 10, page: 3, stat: Journal Article,

Axillary granular parakeratosis
Srivastava, Monika; Cohen, David
2004 ;10(3):20-20, Dermatology online journal
A 71-year-old man developed a pruritic axillary eruption. Histopathologic examination showed laminated orthokeratosis, parakeratosis, and hypergranulosis. There changes were consistent with a diagnosis of axillary granular parakeratosis. Axillary granular parakeratosis is an intertriginous eruption that is usually found in the axillae of middle-aged women and is characterized clinically by pruritic, erythematous, hyperkeratotic plaques and histologically by parakeratosis with retention of keratohyaline granules. Pathophysiology is thought to involve a defective profilaggrin-filaggrin pathway. Evidence-based treatment of this disorder is not available
— id: 72633, year: 2004, vol: 10, page: 20, stat: Journal Article,

Allergic contact dermatitis to mango flesh
Weinstein, Sari; Bassiri-Tehrani, Shirley; Cohen, David E
2004 Apr;43(3):195-196, International journal of dermatology
A 22-year-old white female student presented to the Emergency Department with a 2-day history of patchy pruritic erythema of the face, neck, and arms with periorbital edema. The eruption began as an isolated patch of nasal erythema, with subsequent extension to involve the entire face. Within 2 days, fine pinpoint papules were noted on the face, anterior chest, neck, and upper extremities. Periorbital edema was present without intraoral abnormalities or laryngeal changes. An erythematous, mildly lichenified plaque was noted on the ventral left wrist. The past medical history was significant for two similar, milder episodes of allergic reactions of uncertain etiology occurring within the previous 2 months. The previous eruptions resolved after treatment with oral loratodine and topical fluocinonide cream 0.05%. The patient denied any history of contact urticaria or new household or personal hygiene contactants, although she did report frequent ingestion of peeled mangoes. Her brother had a history of eczematous dermatitis. In the Emergency Department, the patient was administered intravenous diphenhydramine and a single 50 mg dose of oral prednisone. She continued treatment with a 5-day course of prednisone, 50 mg daily, with loratodine, 20 mg daily, and diphenhydramine as needed; however, no symptomatic improvement was seen over 4 days. She was then advised to restart fluocinonide cream twice daily. Patch testing was performed to the North American Contact Dermatitis Group Standard Series utilizing methods of the International Contact Dermatitis research group with Finn chambers. Mango skin and mango flesh harvested 5 mm below the skin surface were also placed in duplicate and tested under Finn chambers. Positive (1+) reactions were noted to nickel and p-tertbutylphenol formaldehyde resin, and bullous reactions were found to mango skin and surface flesh in duplicate (Fig. 1). Complete avoidance of mango led to resolution of the initial eruption. The clinical relevance of nickel and p-tertbutylphenol formaldehyde resin was thought to be associated with the wrist lesion immediately below a glued portion of a wristwatch strap and metal clasp
— id: 46183, year: 2004, vol: 43, page: 195, stat: Journal Article,

Photocontact allergy to diallyl disulfide
Alvarez, Marcy S; Jacobs, Stacy; Jiang, S Brian; Brancaccio, Ronald R; Soter, Nicholas A; Cohen, David E
2003 Sep;14(3):161-165, American journal of contact dermatitis
Although phototoxic reactions to plants are common, photoallergic contact dermatitis to plants and plant products rarely occurs. Our objective was to review the importance of including diallyl disulfide in the evaluation of patients with suspected photosensitivity. Phototests for ultraviolet B, ultraviolet A, and visible light as well as patch tests and photopatch tests for 49 allergens from the New York University Skin and Cancer Unit Photopatch Test Series were performed. Three patients had positive photopatch-test results to diallyl disulfide, which is the allergen in garlic. The authors conclude that although photocontact allergy to diallyl disulfide is rare, this allergen should be included in photopatch-test series
— id: 43238, year: 2003, vol: 14, page: 161, stat: Journal Article,

Hypersensitivity reactions to products and devices in plastic surgery
Cohen, David E; Kaufmann, Julie M
2003 Jun;11(2):253-265, Facial plastic surgery clinics of North America
— id: 46231, year: 2003, vol: 11, page: 253, stat: Journal Article,

Bilateral palmar dermatitis
Bassiri, Shirley; Cohen, David E
2002 Jun;13(2):75-76, American journal of contact dermatitis
— id: 39641, year: 2002, vol: 13, page: 75, stat: Journal Article,

Treatment of cutaneous T-cell lymphoma with alitretinoin gel
Bassiri-Tehrani, Shirley; BA, B A; Cohen, David E
2002 Feb;41(2):104-106, International journal of dermatology
— id: 39659, year: 2002, vol: 41, page: 104, stat: Journal Article,

Identification and quantification of para-phenylenediamine in a temporary black henna tattoo
Brancaccio, Ronald R; Brown, Lance H; Chang, Young Tae; Fogelman, Joshua P; Mafong, Erick A; Cohen, David E
2002 Mar;13(1):15-18, American journal of contact dermatitis
BACKGROUND: Temporary black henna tattoos are very popular as body adornment. Although contact allergy to natural henna is unusual, the inclusion of hair dye, p-phenylenediamine (PPD), increases the risk of contact sensitization. OBJECTIVE: This study was performed to identify the presence and concentration of PPD in a black henna tattoo mixture to which our patient developed contact allergy. METHODS: The presence of PPD in a black henna tattoo mixture, various samples of commercially available henna powders, and several hair dye products was qualitatively and quantitatively detected using high performance liquid chromatography (HPLC). RESULTS: This study demonstrated that PPD was present in the black henna tattoo mixture at a concentration of 15.7%, which is significantly higher than commercial hair dye preparations. CONCLUSION: The presence of PPD in black henna tattoo mixtures in high concentration poses a health hazard and a risk of allergic contact sensitization with potential long-term consequences
— id: 34899, year: 2002, vol: 13, page: 15, stat: Journal Article,

Cutaneous lidocaine allergy confirmed by patch testing
Kaufmann, Julie M; Hale, Elizabeth K; Ashinoff, Robin A; Cohen, David E
2002 Sep;1(2):192-194, Journal of drugs in dermatology : JDD
A case is presented of a 55-year old woman who developed an eruption suggestive of contact dermatitis on repeated occasions after receiving anesthesia for dermatologic procedures. Patch testing revealed a positive reaction to lidocaine. Basic structures of anesthetics are reviewed, and the classification of immunologically-mediated allergic reactions is discussed. The presence of cutaneous lidocaine allergy has profound implications for the field of dermatology
— id: 38608, year: 2002, vol: 1, page: 192, stat: Journal Article,

Contact dermatitis to botanical extracts
Kiken, David A; Cohen, David E
2002 Sep;13(3):148-152, American journal of contact dermatitis
A review of the literature of reported cases of contact dermatitis to a variety of natural herbal extracts is Presented. Natural extracts are commonly used ingredients in many cosmetic preparations and homeopathic remedies. Although the term natural botanical extracts inherently purports to have beneficial and benign properties, these extracts can cause adverse reactions in individuals. As such, dermatologists should be cognizant of these agents as possible sources of allergenicity in patients presenting with contact dermatitis
— id: 39610, year: 2002, vol: 13, page: 148, stat: Journal Article,

A provocative case: phototesting does not reproduce the lesions of actinic granuloma
Kiken, David A; Shupack, Jerome L; Soter, Nicholas A; Cohen, David E
2002 Dec;18(6):315-316, Photodermatology, photoimmunology, & photomedicine
— id: 43239, year: 2002, vol: 18, page: 315, stat: Journal Article,

Clinical course of locally advanced breast cancer (LABC) patients with pathological response to primary concurrent 5-fluorouracil and radiation (FU/RT)
Formenti, S. C.; Cohen, D.; Tsao-Wei, D. D.; Muggia, F. M.
2001 ;51(3 Supplement 1):195-196, International journal of radiation oncology biology physics
— id: 109249, year: 2001, vol: 51, page: 195, stat: Journal Article,

Diagnostic tests for type IV or delayed hypersensitivity reactions
Cohen DE; Brancaccio RR; Soter NA
2000 ;15:287-305, Clinical allergy & immunology
— id: 11548, year: 2000, vol: 15, page: 287, stat: Journal Article,

Toxic epidermal necrolysis following treatment with oxaprozin
Carucci JA; Cohen DE
1999 Mar;38(3):233-234, International journal of dermatology
— id: 16322, year: 1999, vol: 38, page: 233, stat: Journal Article,

Facial dermatitis in a plastics factory worker
Gallagher C; Cohen D; Brancaccio R
1999 Sep;10(3):167-168, American journal of contact dermatitis
— id: 6175, year: 1999, vol: 10, page: 167, stat: Journal Article,

Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens
Mark KA; Brancaccio RR; Soter NA; Cohen DE
1999 Jan;135(1):67-70, Archives of dermatology
BACKGROUND: The panel of patch test allergens used for the evaluation of patients with suspected photoallergy typically does not include plant and pesticide allergens. The prevalence of allergic contact dermatitis and photoallergic contact dermatitis to plant and pesticide allergens was determined for this subgroup of patients. OBSERVATION: Positive reactions were detected in 12 of 26 patients who were tested with our photoallergen series: 5 with allergic contact dermatitis, 5 with photoallergic contact dermatitis, and 2 with both. Four of the 12 patients had positive patch and photo-patch test reactions to plant allergens, pesticide allergens, or both. The positive patch test reactions were to the plants Taraxacum officinale (dandelion) and Tanacetum vulgare (tansy) and to the pesticides folpet and captafol. Positive photo-patch test reactions were to the pesticides folpet and captan. The histories of the patients suggested that 2 or 3 of the 4 patients had clinically relevant reactions. In the other 8 patients, positive reactions to the patch and photo-patch tests included fragrances, sunscreens, and antibacterial agents. CONCLUSION: Plant and pesticide allergens should be included in the patch and photo-patch test series used for the evaluation of patients with suspected photoallergy
— id: 7401, year: 1999, vol: 135, page: 67, stat: Journal Article,

The leukotriene antagonist zafirlukast as a therapeutic agent for atopic dermatitis
Carucci JA; Washenik K; Weinstein A; Shupack J; Cohen DE
1998 Jul;134(7):785-786, Archives of dermatology
— id: 7525, year: 1998, vol: 134, page: 785, stat: Journal Article,

American Academy of Dermatology's position paper on latex allergy
Cohen DE; Scheman A; Stewart L; Taylor J; Pratt M; Trotter K; Prawer S; Warshaw E; Rietschel R; Watsky K; Schwarzenberger K; Zug K; Shama S; Godwin L; Kosann MK; Wilson BA
1998 Jul;39(1):98-106, Journal of the American Academy of Dermatology
— id: 16323, year: 1998, vol: 39, page: 98, stat: Journal Article,

Concurrent paclitaxel and radiation therapy in locally advanced breast cancer
Formenti, SC; Skinner, KA; Spicer, D; Russell, C; Cohen, D; Kutsch, K
1998 ;209P(1):248-248 #462, Radiology
— id: 109275, year: 1998, vol: 209P, page: 248, stat: Journal Article,

Six-hour versus 48-hour patch testing with varying concentrations of potassium dichromate
Kosann MK; Brancaccio RR; Shupack JL; Franks AG Jr; Cohen DE
1998 Jun;9(2):92-95, American journal of contact dermatitis
This study examines the possibility of using patch contact times shorter in duration than the standard 48 hours. Using varying concentrations of potassium dichromate (K2Cr2O7), this study analyzed results from two sets of patches applied to the backs of 11 subjects for durations of 6 and 48 hours, respectively. Results showed that after the 48-hour application period, all subjects reacted to K2Cr2O7 at some concentration. For the patches applied for 6 hours, 7 of the 11 subjects (64%) reacted to K2Cr2O7 at some concentration. Minimum elicitation thresholds (METs), the lowest concentration at which a reaction was observed, were established for both the 6-hour and 48-hour application times. The ratio of an individual's 6-hour MET to their 48-hour MET was calculated to evaluate the feasibility of patch testing with a higher concentration of an allergen for a shorter time period. Although the results clearly indicated that a higher concentration of allergen is required in order to elicit a reaction at 6 versus 48 hours, a fair amount of interindividual variability is exhibited by these 6-hour to 48-hour MET ratios. This observed variability would seem to preclude the use of 6-hour duration patch contact times for routine patch testing with K2Cr2O7
— id: 12112, year: 1998, vol: 9, page: 92, stat: Journal Article,

Chronic actinic dermatitis: results of patch and photopatch tests with Compositae, fragrances, and pesticides
Lim HW; Cohen D; Soter NA
1998 Jan;38(1):108-111, Journal of the American Academy of Dermatology
— id: 16946, year: 1998, vol: 38, page: 108, stat: Journal Article,

Utility of a standard allergen series alone in the evaluation of allergic contact dermatitis: a retrospective study of 732 patients
Cohen DE; Brancaccio R; Andersen D; Belsito DV
1997 Jun;36(6 Pt 1):914-918, Journal of the American Academy of Dermatology
BACKGROUND: Patch testing remains the standard for the diagnosis of allergic contact dermatitis. The validity and usefulness of a standard patch test allergen series has not been addressed adequately by previous studies. OBJECTIVE: We sought to examine the utility of the standard allergen series as a sole screening tool in the diagnosis of allergic contact dermatitis. METHODS: The charts of 732 patients referred for patch testing were reviewed for positive patch test results. The group of patients with positive reactions was stratified into two groups based on the clinical relevance of their reactions. These groups were subsequently analyzed to determine whether the reactions were to part of the standard series of allergens or to part of a supplementary group. RESULTS: Of patients tested, 50% had a positive patch test. Of those, 221 (30%) had reactions deemed clinically relevant. Only 23% of patients with positive patch tests reacted to an allergen(s) in the standard series exclusively. When adjusted for clinical relevance, only 15.7% of patients were completely evaluated with the standard series of 20 allergens. CONCLUSION: The standard allergen series of 20 allergens available in the United States is limited as a screening tool when used alone in the evaluation of patients with allergic contact dermatitis
— id: 12312, year: 1997, vol: 36, page: 914, stat: Journal Article,

What is new in clinical research in contact dermatitis
Cohen DE; Brancaccio RR
1997 Jan;15(1):137-148, Dermatologic clinics
The field of cutaneous allergy has enjoyed dynamic research advances in epidemiology and clinical contact dermatitis. Studies regarding outcomes analysis, validity, predictive value, and sensitivity have allowed clinicians to better understand the importance of patch test results. In the clinical arena, new and clinically relevant allergens are being discovered, such as corticosteroids, metals, preservatives, surfactants, and glues. Continued epidemiologic surveillance of new allergens will enable manufacturers to develop safer products for patients to use
— id: 12429, year: 1997, vol: 15, page: 137, stat: Journal Article,

Spiny keratoderma in association with autosomal dominant polycystic kidney disease with liver cysts [see comments]
Anderson D; Cohen DE; Lee HS; Thellman C
1996 May;34(5 Pt 2):935-936, Journal of the American Academy of Dermatology
Spiny keratoderma of the palms and soles has been rarely reported. Debate exists regarding the proper nosologic classification of this disorder. We describe a patient and her mother with concurrent autosomal dominant polycystic kidney disease with liver cysts
— id: 12619, year: 1996, vol: 34, page: 935, stat: Journal Article,

Contact leukoderma secondary to para-phenylenediamine
Brancaccio R; Cohen DE
1995 May;32(5):313-313, Contact dermatitis
— id: 6810, year: 1995, vol: 32, page: 313, stat: Journal Article,

A tribute to Bernie
Baer RL; Bystryn JC; Cohen D; Curwin J; Freedberg IM; Kopf AW; Lipkin G; Podwal M; Shupack J
1994 Feb;16(1):89-96, American journal of dermatopathology
— id: 16106, year: 1994, vol: 16, page: 89, stat: Journal Article,

Confluent and reticulated papillomatosis: response to high-dose oral isotretinoin therapy and reassessment of epidemiologic data
Lee MP; Stiller MJ; McClain SA; Shupack JL; Cohen DE
1994 Aug;31(2 Pt 2):327-331, Journal of the American Academy of Dermatology
Confluent and reticulated papillomatosis is most probably a disorder of keratinization rather than a fungal infection. We describe an 18-year-old man who was effectively treated with high-dose oral isotretinoin. Our review of the literature on confluent and reticulated papillomatosis refutes previously accepted epidemiologic data
— id: 12932, year: 1994, vol: 31, page: 327, stat: Journal Article,

New York University therapeutic roundtable: a panel of experts answer questions on the treatment of challenging cases
Shupack JL; Kanof N; Stolman LP; Vogel L; Whitlow M; Cohen DE; Washenik K; Lee MP; Stiller MJ
1994 Jul;54(1):29-33, Cutis
— id: 6750, year: 1994, vol: 54, page: 29, stat: Journal Article,

A double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of thymopentin as an adjunctive treatment in atopic dermatitis
Stiller MJ; Shupack JL; Kenny C; Jondreau L; Cohen DE; Soter NA
1994 Apr;30(4):597-602, Journal of the American Academy of Dermatology
BACKGROUND: Multiple immunologic abnormalities such as impaired T-cell function, elevated serum IgE level, and increased interleukin 4 production have been demonstrated in patients with atopic dermatitis. OBJECTIVE: As part of a 12-week, multicenter, double-blind, placebo-controlled clinical trial, we evaluated the safety and efficacy of thymopentin (Timunox) as an adjunctive treatment in patients with severe atopic dermatitis. METHODS: Thirty-nine patients at least 2 years old with severe atopic dermatitis on a minimum of 20% of their cutaneous surface area were randomly selected to receive either thrice-weekly subcutaneous injections of thymopentin, 50 mg, or placebo. Use of triamcinolone 0.1% or hydrocortisone 1.0% cream and oral antihistamines were permitted during this trial. RESULTS: After 12 weeks, thymopentin-treated patients had significantly greater improvement than those receiving placebo. No thymopentin-related adverse events occurred. CONCLUSION: Thymopentin may be a safe effective adjunct to therapy in patients with severe atopic dermatitis
— id: 12978, year: 1994, vol: 30, page: 597, stat: Journal Article,

Trichophytosis gladiatorum
Cohen DE; Foa H; Sangueza OP
1993 Jun;28(6):1022-1022, Journal of the American Academy of Dermatology
— id: 16324, year: 1993, vol: 28, page: 1022, stat: Journal Article,

In vivo cutaneous surface microscopy: revised nomenclature
Cohen DE; Sangueza OP; Fass E; Stiller MJ
1993 Apr;32(4):257-258, International journal of dermatology
— id: 13193, year: 1993, vol: 32, page: 257, stat: Journal Article,