Edwin S Chan

Biosketch / Results /

Edwin S Chan, M.D.

Clinical Assistant Professor;
Department of Medicine (Medicine)

Contact Info

Address
550 First Avenue
Floor 2 Room 251
Medical Science Building
New York, NY 10016-6481

212-263-6275
646-501-6840
Edwin.Chan@nyumc.org

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Education

— Queen's University, Canada, Residency
— Queen's University, Canada, Clinical Fellowships
— University of Dundee, Scotland, Internship
— NYU School of Medicine, PostDoctoral Training
1990 — University of Dundee, Scotland, Medical Education

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Research Summary

Liver fibrosis, or cirrhosis in its end stage form, is one of the most devastating complications of alcohol consumption and is responsible for much of the morbidity and mortality in the western world, whether due to alcohol abuse, liver infections, drugs or chemical toxins. Our interest in hepatic fibrosis stems from pioneering work by Bruce Cronstein who first demonstrated that the purine nucleoside, adenosine, is a potent antiinflammatory agent, and mediates much of the antiinflammatory effects of methotrexate and other medications commonly used in the treatment of rheumatoid arthritis and other inflammatory diseases. Since liver fibrosis is also one of the most severe of complications observed in patients treated with methotrexate, and adenosinergic agents promote ground matrix production in wounds, we postulated that the released adenosine may be responsible for the development of hepatic fibrosis in methotrexate-treated patients.
Our prior observations show that both methotrexate and ethanol induce the release of adenosine from liver cells, which in turn acts on a specific cell surface receptor, the A2A receptor, on hepatic stellate cells to promote collagen synthesis. These in vitro observations are supported by the in vivo demonstration that mice rendered genetically deficient for the adenosine A2A receptor are protected against liver fibrosis in a widely accepted chemical model, induction by carbon tetrachloride.
The importance of adenosine and its receptors in their mediation of liver cirrhosis is only just beginning to be appreciated. Ongoing studies in our laboratory examine the influence of adenosine on collagen formation vs. breakdown, intracellular mechanisms involved in signaling an increase in collagen production (cyclic AMP/protein kinase A pathway and mitogen-activated protein kinase pathway), and further animal models of toxin-induced hepatic fibrosis. We believe that elucidation of the molecular pathways of hepatic fibrogenesis will lead to potential therapeutic targets for cirrhosis, a disease for which there is presently no cure, and our encouraging preliminary results lead us to believe that this is an achievable goal.

Research Interests

Molecular Regulation of Fibrogenesis<br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Differences in psychiatric symptoms among Asian patients with depression: a multi-country cross-sectional study
Sulaiman, Ahmad H; Bautista, Dianne; Liu, Chia-Yih; Udomratn, Pichet; Bae, Jae Nam; Fang, Yiru; Chua, Hong C; Liu, Shen-Ing; George, Tom; Chan, Edwin; Tian-mei, Si; Hong, Jin Pyo; Srisurapanont, Manit; Rush, A John
2014 Apr;68(4):245-254, Psychiatry & clinical neurosciences
— id: 992402, year: 2014, vol: 68, page: 245, stat: Journal Article,

Mechanisms of action of methotrexate
Chan, Edwin S L; Cronstein, Bruce N
2013 ;71 Suppl 1:S5-S8, Bulletin of the Hospital for Joint Diseases (2013)
— id: 761472, year: 2013, vol: 71 Suppl 1, page: S5, stat: Journal Article,

Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis
Fernandez, Patricia; Perez-Aso, Miguel; Smith, Gideon; Wilder, Tuere; Trzaska, Sean; Chiriboga, Luis; Franks, Andrew Jr; Robson, Simon C; Cronstein, Bruce N; Chan, Edwin S L
2013 Dec;183(6):1740-1746, American journal of pathology
— id: 652432, year: 2013, vol: 183, page: 1740, stat: Journal Article,

Adenosine 2A Receptor Promotes Collagen Production By Human Fibroblasts Via Smad2/3-Independent Pathways Involving Cyclic AMP and AKT
Perez-Aso, Miguel ; Fernandez, Patricia ; Mediero, Aranzazu ; Chan, Edwin S. L. ; Cronstein, Bruce N.
2013 OCT;65 10 10(SI):S790-S790, Arthritis & rheumatism
— id: 657292, year: 2013, vol: 65 10 10, page: S790, stat: Journal Article,

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3
Perez-Aso, Miguel; Fernandez, Patricia; Mediero, Aranzazu; Chan, Edwin S; Cronstein, Bruce N
2013 Nov;:1740-1746, FASEB journal
— id: 761482, year: 2013, vol: , page: 1740, stat: Journal Article,

Adenosine A2A Receptors (A2AR) Promote Scarring By Repressing Mir-29a
Radusky, Ross C. ; Perez-Aso, Miguel ; Franks, Andrew G., Jr. ; Cronstein, Bruce N. ; Chan, Edwin S. L.
2013 OCT;65 10 10(SI):S790-S790, Arthritis & rheumatism
— id: 657302, year: 2013, vol: 65 10 10, page: S790, stat: Journal Article,

Cholesterol 27-Hydroxylase but Not Apolipoprotein apoE Contributes to A(2A) Adenosine Receptor Stimulated Reverse Cholesterol Transport
Bingham TC; Parathath S; Tian H; Reiss A; Chan E; Fisher EA; Cronstein BN
2012 Feb;35(1):49-57, Inflammation
— id: 122556, year: 2012, vol: 35, page: 49, stat: Journal Article,

Adenosine modulation of the pro-fibrogenic cytokine IL-13occurs viathe A2A adenosinereceptor
Franks, L; Radusky, R; Feig, J; Fernandez, P; Cronstein, B; Chan, E
2012 February 2012;51:i15-i15, Rheumatology (Oxford)
— id: 157715, year: 2012, vol: 51, page: i15, stat: Journal Article,

Adenosine A2A receptors promote wound healing by modulating miR-29a signaling
Radusky, R. C.; Cronstein, B. N.; Chan, E. S.; Perez-Aso, M.; Franks, A. G.
2012 SEP;132 2 2:S8-S8, Journal of investigative dermatology
— id: 177761, year: 2012, vol: 132 2 2, page: S8, stat: Journal Article,

The pro-fibrotic cytokines IL-33 and IL-13 modulate dermal fibrosis via the A2A adenosine receptor
Radusky, R. C.; Franks, L.; Feig, J.; Fernandez, P.; Franks, A. G.; Cronstein, B. N.; Chan, E. S.
2012 MAY;132:S10-S10, Journal of investigative dermatology
— id: 165684, year: 2012, vol: 132, page: S10, stat: Journal Article,

The Pro-Fibrotic Cytokines IL-33 and IL-13 Modulates Dermal Fibrosis Via the A2A Adenosine Receptor
Radusky, Ross C.; Feig, Jessica L.; Cronstein, Bruce N.; Franks, Andrew G.; Chan, Edwin S. L.
2012 OCT;64(10 S S):S768-S769, Arthritis & rheumatism
— id: 183952, year: 2012, vol: 64, page: S768, stat: Journal Article,

Adenosine receptor signaling in keratinocyte proliferation and implications for caffeine and methotrexate therapy
Smith, Gideon; Franks, Andrew; Cronstein, Bruce; Chan, Edwin
2012 APR;66(4):AB34-AB34, Journal of the American Academy of Dermatology
— id: 165686, year: 2012, vol: 66, page: AB34, stat: Journal Article,

Adenosine-mediated dermal fibrosis and Fli-1 expression in CD39 and CD73 knockout mice
Smith, Gideon; Franks, Andrew; Cronstein, Bruce; Chan, Edwin; Liu, Hailing; Fernandez, Patricia
2012 APR;66(4):AB2-AB2, Journal of the American Academy of Dermatology
— id: 165685, year: 2012, vol: 66, page: AB2, stat: Journal Article,

Adenosine-Mediated Dermal Fibrosis and Fli-1 Expression in CD39 and CD73 Knockout Mice
Chan, Edwin S. L.; Smith, Gideon; Fernandez, Patricia; Liu, Hailing; Franks, Andrew G.; Trojanowska, Maria; Cronstein, Bruce N.
2011 OCT;63(10):S907-S907, Arthritis & rheumatism
— id: 165688, year: 2011, vol: 63, page: S907, stat: Journal Article,

Methotrexate in atherogenesis and cholesterol metabolism
Coomes, Eric; Chan, Edwin S L; Reiss, Allison B
2011 ;2011:503028-503028, Cholesterol
— id: 130917, year: 2011, vol: 2011, page: 503028, stat: Journal Article,

Adenosine Receptor Signaling in Keratinocyte Proliferation and Implications for Caffeine and Methotrexate Therapy
Smith, Gideon; Franks, Andrew G.; Cronstein, Bruce N.; Chan, Edwin S. L.
2011 OCT;63(10):S206-S206, Arthritis & rheumatism
— id: 165687, year: 2011, vol: 63, page: S206, stat: Journal Article,

A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux
Bingham, Taiese Crystal; Fisher, Edward A; Parathath, Saj; Reiss, Allison B; Chan, Edwin S; Cronstein, Bruce N
2010 Apr;87(4):683-690, Journal of leukocyte biology
— id: 108919, year: 2010, vol: 87, page: 683, stat: Journal Article,

Adenosine in fibrosis
Chan, Edwin S L; Cronstein, Bruce N
2010 Apr;20(2):114-122, Modern rheumatology (Japan Rheumatism Association)
— id: 109055, year: 2010, vol: 20, page: 114, stat: Journal Article,

Methotrexate-how does it really work?
Chan, Edwin S L; Cronstein, Bruce N
2010 Mar;6(3):175-178, Nature reviews. Rheumatology
— id: 107789, year: 2010, vol: 6, page: 175, stat: Journal Article,

CD39/CD73 double knockout mice are protected against bleomycin-induced dermal fibrosis
Chan, Edwin; Fernandez, Patricia; Liu, Hailing; Robson, Simon; Cronstein, Bruce
2010 JUN ;6(6000):133-133, Purinergic signalling
— id: 113751, year: 2010, vol: 6, page: 133, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating fli1 and CTGF expression
Liu H.; Chan E.; Fernandez P.; Cronstein B.N.
2010 ;62:600-600, Arthritis & rheumatism
— id: 130925, year: 2010, vol: 62, page: 600, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating Fli1 and CTGF expression
Liu, Hailing; Chan, Edwin; Fernandez, Patricia; Karuvelil, Rina; Cronstein, Bruce
2010 JUN ;6(6000):142-142, Purinergic signalling
— id: 113752, year: 2010, vol: 6, page: 142, stat: Journal Article,

Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease
Reiss, Allison B; Anwar, Kamran; Merrill, Joan T; Chan, Edwin S L; Awadallah, Nahel W; Cronstein, Bruce N; Michael Belmont, H; Belilos, Elise; Rosenblum, Gary; Belostocki, Kristina; Bonetti, Lois; Hasneen, Kowser; Carsons, Steven E
2010 Mar;30(5):591-598, Rheumatology international
— id: 122562, year: 2010, vol: 30, page: 591, stat: Journal Article,

Molecular pathogenesis of skin fibrosis: insight from animal models
Smith, Gideon P; Chan, Edwin S L
2010 Feb;12(1):26-33, Current rheumatology reports
— id: 109529, year: 2010, vol: 12, page: 26, stat: Journal Article,

Cholesterol 27-hydroxylase but not apolipoprotein e contributes to A2A adenosine receptor enhanced reverse cholesterol transport
Bingham T.C.; Parahath S.; Reiss A.; Chan E.S.L.; Fisher E.; Cronstein B.N.
2009 ;60:433-433, Arthritis & rheumatism
— id: 130321, year: 2009, vol: 60, page: 433, stat: Journal Article,

Celecoxib Atherogenicity: Promotion of Foam Cell Formation (FCF) and Inhibition of ABCA1 in THP-1 Human Macrophages
Reiss, AB; Edelman, SD; Anwar, K; Chan, ES; Wirkowski, PA; Carsons, SE
2009 MAR 10 ;53(10):A426-A426, Journal of the American College of Cardiology
— id: 97558, year: 2009, vol: 53, page: A426, stat: Journal Article,

Disruption of cholesterol efflux by coxib medications and inflammatory processes: link to increased cardiovascular risk
Reiss, Allison B; Anwar, Farah; Chan, Edwin S L; Anwar, Kamran
2009 Aug;57(6):695-702, Journal of investigative medicine
— id: 101315, year: 2009, vol: 57, page: 695, stat: Journal Article,

A BRIEF COMMUNICATION: Enhanced CD36 Scavenger Receptor Expression in THP-1 Human Monocytes in the Presence of Lupus Plasma: Linking Autoimmunity and Atherosclerosis
Reiss, Allison B; Wan, David W; Anwar, Kamran; Merrill, Joan T; Wirkowski, Peter A; Shah, Nidhi; Cronstein, Bruce N; Chan, Edwin S L; Carsons, Steven E
2009 Mar;234(3):354-360, Experimental biology & medicine
— id: 94422, year: 2009, vol: 234, page: 354, stat: Journal Article,

Modulation of Il-13 and Fli1 by adenosine - Implications for scleroderma
Chan, ES; Liu, H; Fernandez, P; Luna, A; Blackbum, M; Trojanowska, M; Cronstein, B
2008 SEP ;58(9):S833-S834, Arthritis & rheumatism
— id: 88573, year: 2008, vol: 58, page: S833, stat: Journal Article,

Adenosine A(2A) receptor occupancy stimulates wound matrix production by modulating IL-13 and FLI1 expression
Fernandez, P; Luna, A; Trojanowska, M; Cronstein, BN; Chan, ESL
2008 MAR-APR ;16(2):A28-A28, Wound repair & regeneration
— id: 76411, year: 2008, vol: 16, page: A28, stat: Journal Article,

Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine
Fernandez, Patricia; Trzaska, Sean; Wilder, Tuere; Chiriboga, Luis; Blackburn, Michael R; Cronstein, Bruce N; Chan, Edwin S L
2008 Jun;172(6):1675-1682, American journal of pathology
— id: 79444, year: 2008, vol: 172, page: 1675, stat: Journal Article,

Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis
Katebi, Majid; Fernandez, Patricia; Chan, Edwin S L; Cronstein, Bruce N
2008 Oct;31(5):299-303, Inflammation
— id: 93354, year: 2008, vol: 31, page: 299, stat: Journal Article,

Adenosine A2A receptor occupancy promotes dermal fibrosis by modulating II-13 and Fli1 expression
Liu, HL; Fernandez, P; Luna, A; Blackburn, M; Trojanowska, M; Cronstein, B; Chan, E
2008 MAY ;4(1):S63-S64, Purinergic signalling
— id: 86661, year: 2008, vol: 4, page: S63, stat: Journal Article,

Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
Peng, Zhongsheng; Fernandez, Patricia; Wilder, Tuere; Yee, Herman; Chiriboga, Luis; Chan, Edwin S L; Cronstein, Bruce N
2008 Jul;22(7):2263-2272, FASEB journal
— id: 79442, year: 2008, vol: 22, page: 2263, stat: Journal Article,

Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis
Peng, Zhongsheng; Fernandez, Patricia; Wilder, Tuere; Yee, Herman; Chiriboga, Luis; Chan, Edwin S L; Cronstein, Bruce N
2008 Jun;27(6):821-824, Nucleosides, nucleotides & nucleic acids
— id: 79449, year: 2008, vol: 27, page: 821, stat: Journal Article,

Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages
Reiss, Allison B; Carsons, Steven E; Anwar, Kamran; Rao, Soumya; Edelman, Sari D; Zhang, Hongwei; Fernandez, Patricia; Cronstein, Bruce N; Chan, Edwin S L
2008 Dec;58(12):3675-3683, Arthritis & rheumatism
— id: 94423, year: 2008, vol: 58, page: 3675, stat: Journal Article,

Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts
Tagoe, Clement E; Marjanovic, Nada; Park, Jean Y; Chan, Edwin S; Abeles, Aryeh M; Attur, Mukundan; Abramson, Steven B; Pillinger, Michael H
2008 Aug 15;181(4):2813-2820, Journal of immunology
— id: 87806, year: 2008, vol: 181, page: 2813, stat: Journal Article,

Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors
Abeles, Aryeh M; Marjanovic, Nada; Park, Jean; Attur, Mukundan; Chan, Edwin S; Al-Mussawir, Hayf E; Dave, Mandar; Fisher, Mark C; Stuchin, Steven A; Abramson, Steven B; Pillinger, Michael H
2007 Sep;56(9):2840-2853, Arthritis & rheumatism
— id: 93879, year: 2007, vol: 56, page: 2840, stat: Journal Article,

Adenosine in inflammatory joint diseases
Chan, E S L; Fernandez, P; Cronstein, B N
2007 Mar;3(1-2):145-152, Purinergic signalling
— id: 105910, year: 2007, vol: 3, page: 145, stat: Journal Article,

Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk
Chan, Edwin S L; Zhang, Hongwei; Fernandez, Patricia; Edelman, Sari D; Pillinger, Michael H; Ragolia, Louis; Palaia, Thomas; Carsons, Steven; Reiss, Allison B
2007 ;9(1):R4-R4, Arthritis research & therapy
— id: 71926, year: 2007, vol: 9, page: R4, stat: Journal Article,

Methotrexate in rheumatoid arthritis
Chan, Edwin Sl; Fernandez, Patricia; Cronstein, Bruce N
2007 Jan;3(1):27-33, Expert review of clinical immunology
— id: 110109, year: 2007, vol: 3, page: 27, stat: Journal Article,

Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway
Che, Jiantu; Chan, Edwin S L; Cronstein, Bruce N
2007 Dec;72(6):1626-1636, Molecular pharmacology
— id: 75450, year: 2007, vol: 72, page: 1626, stat: Journal Article,

Disruption of cholesterol transport by celecoxibb and COX-2 silencing: A potential mechanism of increased cardiovascular (CV) risk
Edelman, SD; Anwar, K; Chan, ES; Wirkowski, P; Morano, J; Carsons, SE; Reiss, AB
2007 DEC ;56(12):4244-4244, Arthritis & rheumatism
— id: 87211, year: 2007, vol: 56, page: 4244, stat: Journal Article,

Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience
Taouli, Bachir; Tolia, Anuj J; Losada, Mariela; Babb, James S; Chan, Edwin S; Bannan, Michael A; Tobias, Hillel
2007 Oct;189(4):799-806, American journal of roentgenology
— id: 74407, year: 2007, vol: 189, page: 799, stat: Journal Article,

Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
Chan, E S L; Fernandez, P; Merchant, A A; Montesinos, M C; Trzaska, S; Desai, A; Tung, C F; Khoa, D N; Pillinger, M H; Reiss, A B; Tomic-Canic, M; Chen, J F; Schwarzschild, M A; Cronstein, B N
2006 Aug;54(8):2632-2642, Arthritis & rheumatism
— id: 68662, year: 2006, vol: 54, page: 2632, stat: Journal Article,

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
Chan, Edwin S L; Montesinos, Maria Carmen; Fernandez, Patricia; Desai, Avani; Delano, David L; Yee, Herman; Reiss, Allison B; Pillinger, Michael H; Chen, Jiang-Fan; Schwarzschild, Michael A; Friedman, Scott L; Cronstein, Bruce N
2006 Aug;148(8):1144-1155, British journal of pharmacology
— id: 66126, year: 2006, vol: 148, page: 1144, stat: Journal Article,

Adenosine A(2A) receptors and dermal fibrosis: a pathogenic role for adenosine in diffuse dermal fibrosis
Chan, ESL; Fernandez, P; Merchant, AA; Desai, A; Montesinos, MC; Tung, CF; Khoa, DN; Pillinger, MH; Reiss, AB; Tomic-Canic, M; Chen, JF; Schwarzschild, MA; Cronstein, BN
2006 SEP ;11(1):144-144, Journal of investigative dermatology symposium proceedings
— id: 76164, year: 2006, vol: 11, page: 144, stat: Journal Article,

Adenosine modulation in vivo - Implications for dermal fibrogenesis in seleroderma
Fernandez, P; Trzaska, SM; Wilder, T; Fernandez, M; Blackburn, MR; Cronstein, BN; Chan, ESL
2006 SEP ;54(9):S726-S727, Arthritis & rheumatism
— id: 70134, year: 2006, vol: 54, page: S726, stat: Journal Article,

Methotrexate counters the atherogenic effect of cox-2 inhibition and IFN-gamma and prevents foam cell transformation in THP-1 human monocytes/Macrophages
Rao, SG; Zhang, H; Chan, ESL; Ragolia, L; Edelman, SD; Carsons, S; Reiss, AB
2006 SEP ;54(9):S233-S233, Arthritis & rheumatism
— id: 70109, year: 2006, vol: 54, page: S233, stat: Journal Article,

Unraveling coxib atherogenicity: Adenosine A2A receptor agonists reverse disruption of cholesterol efflux induced by cyclooxygenase (COX)-2 inhibition
Reiss, A; Zhang, H; Edelman, S; Carsons, S; Ragolia, L; Fernandez, P; Chan, E
2006 OCT ;55(11):S117-S118, Inflammation research
— id: 69259, year: 2006, vol: 55, page: S117, stat: Journal Article,

Atherogenic properties of lupus plasma: Increased foam cell transformation and CD36 scavenger receptor and diminished cholesterol 27-hydroxylase
Reiss, AB; Wan, DW; Merrill, JT; Zhang, HW; Chan, ESL; Rao, S; Belilos, E; Bonetti, L; Rosenblum, G; Belostocki, K; Belmont, HM; Cronstein, BN; Carsons, S
2006 SEP ;54(9):S460-S460, Arthritis & rheumatism
— id: 70122, year: 2006, vol: 54, page: S460, stat: Journal Article,

COX-2 inhibitor-mediated disruption of cholesterol transport is abrogated by addition of prostaglandin D-2 or E-2: Anti-atherogenicity of a functional prostaglandin system
Reiss, AB; Zhang, HW; Edelman, SD; Fernandez, P; Cronstein, BN; Pillinger, MH; Ragolia, L; Carsons, S; Chan, ESL
2006 SEP ;54(9):S403-S404, Arthritis & rheumatism
— id: 70118, year: 2006, vol: 54, page: S403, stat: Journal Article,

Cox-2 inhibition disrupts cholesterol efflux and promotes atheromatous foam cell transformation: A possible mechanism for increased cardiovascular risk
Reiss, AB; Zhang, HW; Edelman, SD; Fernandez, P; Ragolia, L; Carsons, S; Chan, ES
2006 MAY ;26(5):E98-E98, Arteriosclerosis, thrombosis, & vascular biology
— id: 63870, year: 2006, vol: 26, page: E98, stat: Journal Article,

Cox-2-selective inhibitors interfere with cholesterol transport: A possible mechanism for atherogenic effects
Chan, ESL; Zhang, HW; Fernandez, P; Cronstein, BN; Pillinger, MH; Ragolia, L; Carsons, S; Reiss, AB
2005 SEP ;52(9):S354-S354, Arthritis & rheumatism
— id: 59279, year: 2005, vol: 52, page: S354, stat: Journal Article,

Adenosine A(2A) receptor (A(2A)R) mediates dermal fibrosis in scleroderma
Fernandez, P; Montesinos, C; Desai, A; Pillinger, MH; Reiss, AB; Cronstein, BN; Chan, ESL
2005 SEP ;52(9):S364-S364, Arthritis & rheumatism
— id: 59280, year: 2005, vol: 52, page: S364, stat: Journal Article,

Increased CD36 scavenger receptor expression in THP-1 human monocytes exposed to SLE patient serum
Reiss, AB; Wan, DW; Chan, ES; Cronstein, BN; Zhang, HW; Ragolia, L; Carsons, S
2005 MAY ;25(5):E82-E83, Arteriosclerosis, thrombosis, & vascular biology
— id: 52645, year: 2005, vol: 25, page: E82, stat: Journal Article,

Adenosine A(2A) receptor occupancy promotes collagen production in dermal fibroblasts by inhibition of metalloproteinase activity
Chan, E; Lau, K; Desai, A; Montesinos, C; Reiss, A; Pillinger, M; Cronstein, B
2004 SEP ;50(9):S463-S463, Arthritis & rheumatism
— id: 49048, year: 2004, vol: 50, page: S463, stat: Journal Article,

Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
Pillinger, Michael H; Dinsell, Victoria; Apsel, Beth; Tolani, Sonia N; Marjanovic, Nada; Chan, Edwin S L; Gomez, Paul; Clancy, Robert; Chang, Lih-Fan; Abramson, Steven B
2004 Jul;142(6):973-982, British journal of pharmacology
— id: 48069, year: 2004, vol: 142, page: 973, stat: Journal Article,

Activation of the adenosine A2A receptor increases expression of reverse cholesterol transport (RCT) proteins in monocytes/macrophages
Reiss, A; Rahman, M; Chan, E; Montesinos, M; Hasneen, K
2004 MAY 14 ;18(8):C261-C261, FASEB journal
— id: 46556, year: 2004, vol: 18, page: C261, stat: Journal Article,

Adenosine A2A receptor activation counteracts atherogenic effects of immune reactants on cholesterol flux in macrophages
Reiss, AB; Cronstein, BN; Chan, ES; Montesinos, MC; Ragolia, L; Carsons, S
2004 OCT 26 ;110(17):331-331, Circulation
— id: 55940, year: 2004, vol: 110, page: 331, stat: Journal Article,

Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages
Reiss, Allison B; Patel, Chirag A; Rahman, Mohammad M; Chan, Edwin S L; Hasneen, Kowser; Montesinos, Maria C; Trachman, Julie D; Cronstein, Bruce N
2004 Nov;10(11):BR420-BR425, Medical science monitor
— id: 69497, year: 2004, vol: 10, page: BR420, stat: Journal Article,

Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages
Reiss, Allison B; Rahman, Mohammad M; Chan, Edwin S L; Montesinos, M Carmen; Awadallah, Nahel W; Cronstein, Bruce N
2004 Sep;76(3):727-734, Journal of leukocyte biology
— id: 44864, year: 2004, vol: 76, page: 727, stat: Journal Article,

Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease
Reiss, Allison B; Siller, Keith A; Rahman, Mohammad M; Chan, Edwin S L; Ghiso, Jorge; de Leon, Mony J
2004 Oct;25(8):977-989, Neurobiology of aging
— id: 45967, year: 2004, vol: 25, page: 977, stat: Journal Article,

Involvement of ERK signaling in adenosine A(2A) receptor-induced dermal fibrosis
Chan, ESL; Merchant, AA; Tung, CF; Mayas, J; Reiss, AB; Tomic-Canic, M; Pillinger, MH; Cronstein, BN
2003 SEP ;48(9):S271-S271, Arthritis & rheumatism
— id: 55437, year: 2003, vol: 48, page: S271, stat: Journal Article,

Adenosine A(2A) receptor-deficient mice are protected against bleomycin-induced dermal fibrosis
Chan, ESL; Merchant, AA; Tung, CF; Montesinos, C; Reiss, AB; Pillinger, MH; Cronstein, BN
2003 SEP ;48(9):S669-S669, Arthritis & rheumatism
— id: 55446, year: 2003, vol: 48, page: S669, stat: Journal Article,

Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation
Pillinger, Michael H; Rosenthal, Pamela B; Tolani, Sonia N; Apsel, Beth; Dinsell, Victoria; Greenberg, Jeffrey; Chan, Edwin S L; Gomez, Paul F; Abramson, Steven B
2003 Feb;171(11):6080-6089, Journal of immunology
— id: 46269, year: 2003, vol: 171, page: 6080, stat: Journal Article,

Inhibition of expression of the anti-atherogenic cholesterol 27-hydroxylase in human monocytoid cells exposed to SLE patient serum is abrogated bay blocking the interferon-gamma receptor
Reiss, AB; Merrill, JT; Rahman, MM; Hasneen, K; Chan, ESL; Belmont, HM; Khoa, ND; Cronstein, BN
2003 SEP ;48(9):S196-S196, Arthritis & rheumatism
— id: 55432, year: 2003, vol: 48, page: S196, stat: Journal Article,

Adenosine A2A receptor activation upregulates expression of the cholesterol-metabolizing 27-hydroxylase enzyme and inhibits foam cell transformation in THP-1 human monocytes/macrophages
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Molecular action of methotrexate in inflammatory diseases
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Methotrexate-induced hepatic fibrosis: Adenosine A(2A) receptor is responsible for hepatic collagen production in vivo and protective effect of caffeine
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2002 SEP ;46(9):S546-S547, Arthritis & rheumatism
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Adenosine A(2A) receptor occupancy increases cholesterol 27-hydroxylase (27-OHase) mRNA expression and inhibits foam cell formation in murine macrophages
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Adenosine A(2A) receptor occupancy increases cholesterol 27-hydroxylase (27-OHase) mRNA expression and inhibits foam cell formation in murine macrophages
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2002 SEP ;46(9):S561-S561, Arthritis & rheumatism
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Serum from SLE patients compromises cholesterol homeostasis in cultured human aortic endothelial cells (HAEC) by decreasing cholesterol 27-hydroxylase expression
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2002 SEP ;46(9):S35-S35, Arthritis & rheumatism
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Serum from SLE patients compromises cholesterol Homeostasis in cultured human aortic endothelial cells (HAEC) by decreasing cholesterol 27-hydroxylase expression
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Adenosine mediates the antiinflammatory effects of methotrexate as well as its toxicities
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Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages
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