Biosketch / Results /

Veronica Catanese

Adjunct Associate Professor, Department of Medicine
Cell Biology

Contact Info

212/263-0794
Veronica.Catanese2@nyumc.org

Education

1979 — New York University School of Medicine, Medical Education
1979-1980 — Bellevue Hospital Center, Internship
1979-1980 — NYU Medical Center, Internship
1980-1984 — NYU Medical Center, Residency Training
1980-1984 — Bellevue Hospital Center, Residency Training
1982-1983 — NYU Medical Center (Endocrinology & Metabolism), Clinical Fellowships
1982-1983 — Bellevue Hospital Center (Endocrinology & Metabolism), Clinical Fellowships
1984-1986 — Joslin Diabetes Center (Endocrinology & Metabolism), Clinical Fellowships
1984-1986 — Brigham And Women'S Hospital (Endocrinology & Metabolism), Clinical Fellowships

Research Summary

The physiological stimuli of changing pressure and flow promote compensatory hypertrophy in several organ systems in humans and animals. Renal glomeruli in diabetes and left ventricular myocytes in hypertension display such post-mitotic tissue growth. While these result in initial adaptive benefits to the organism, fibrosis and loss of function of the organ eventually ensue, thereby leading directly to morbidity and mortality from these disease processes. Insulin-like growth factor I (IGF-I) is a peptide structurally and functionally very similar to insulin. IGF-I is less potent than insulin as a metabolic hormone but much more potent than insulin as a mitogenic agent. Unlike insulin, however, IGF-I protein is made in almost all organs, raising the possibility that it might function locally to control tissue growth. Our laboratory identified tissue-specific enhancement of IGF-I gene expression early in both these models of adaptive growth, suggesting that it participates in initiating the hypertrophic response in tissues no longer capable of cell division. We also identified differential regulation of a tissue-specific panel of IGF-binding proteins capable of restricting or promoting access of IGF-I to its receptor.

Current objectives are to: 1) identify the hormonal and physiological stimuli responsible for induction of the IGF-I growth factor axis in vivo and in vitro; 2) elucidate the mechanisms by which these factors regulate expression of the IGF-I and IGF binding protein genes; 3) define the structural and functional consequences of IGF-I overexpression in vivo and in vitro; and 4) determine if tissue-specific expression of IGF-I is necessary and/or sufficient to initiate hypertrophy. To achieve these aims, we combine physiological, molecular, and cell biological techniques and use both intact animal adenoviral expression systems and targeted cell culture for molecular analysis.

Research Interests

Molecular Regulation of Post-Mitotic Tissue Growth

The many missions of medical schools
Smith, Lawrence G; Catanese, Veronica M
2012-02-05; 1539-3704,Annals of internal medicine - id: 133616, year: 2010

A case of student cheating
Catanese, Veronica; Aronson, Paul
2012-12-25; 1937-7010,Virtual mentor : VM - id: 203992, year: 2005 Journal Article

Creating a new structure for research on health care effectiveness
Kupersmith, Joel; Sung, Nancy; Genel, Myron; Slavkin, Harold; Califf, Robert; Bonow, Robert; Sherwood, Louis; Reame, Nancy; Catanese, Veronica; Baase, Catherine; Feussner, John; Dobs, Adrian; Tilson, Hugh; Reece, E Albert
2012-04-14; 1081-5589,Journal of investigative medicine - id: 164320, year: 2005 Journal Article

Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise
Crowley, William F Jr; Sherwood, Louis; Salber, Patricia; Scheinberg, David; Slavkin, Hal; Tilson, Hugh; Reece, E Albert; Catanese, Veronica; Johnson, Stephen B; Dobs, Adrian; Genel, Myron; Korn, Allan; Reame, Nancy; Bonow, Robert; Grebb, Jack; Rimoin, David
2012-04-14; 0098-7484,JAMA - id: 164319, year: 2004 Journal Article; Research Support, Non-U.S. Gov't

Medical humanities at New York University School of Medicine: an array of rich programs in diverse settings
Krackov, Sharon K; Levin, Richard I; Catanese, Veronica; Rey, Mariano; Aull, Felice; Blagev, Denitza; Dreyer, Benard; Grieco, Anthony J; Hebert, Cristy; Kalet, Adina; Lipkin, Mack Jr; Lowenstein, Jerome; Ofri, Danielle; Stevens, David
2012-02-05; 1040-2446,Academic medicine - id: 39038, year: 2003 Journal Article