Jonathan D Brodie

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Jonathan Brodie

Professor, Department of Psychiatry
Psychiatry

Contact Info

Address
1 Park Avenue
New York, NY 10016

212/263-6365


Research Summary

For many years, Dr. Brodie has maintained a close collaboration with Dr. Stephen Dewey and the PET group of Brookhaven National Laboratory. This effort has focused on the investigation of neurotransmitter interactions and their application to clinical issues. We use PET neuroimaging methods with pharmacological perturbations as probes and changes in binding of radioligands to specific neuroreceptors as outcome measures. We pair these human and non-human primate studies with microdialysis studies and behavioral observations as independent measures. With this strategy, we have established that the hallmark of any functioning psychoactive drug is chemical plasticity, expressed as neurotransmitter interactions, i.e. the ability to transmit and transduce a chemical signal to brain regions that may be distinguished in space and/or time. We are actively investigating the complexity of this accommodation with pharmacologic probes in non-human primates, normal controls and patient populations. Measurement of these interactions with PET is now an accepted method for examining pharmacological activity in vivo. Initially, we developed probes to investigate the ability of one neurotransmitter to modulate or be modulated by another functionally linked neurotransmitter system by using multiple radiotracers and pharmacologically specific challenges in the study of schizophrenia. These early studies have since evolved to encompass such areas as neuroleptic response and neurotransmitter stability. More recently our studies of GABAergic modulation of dopamine have led to the exciting findings that the suicide inhibitor of GABA transaminase, GVG, is an extraordinarily effective drug in blocking the use of virtually all drugs of abuse, including cocaine, nicotine, heroin, alcohol, methamphetamine and others. We are actively involved in the extension of these studies to human patients.

Research Interests

Functional neuroimaging of pharmacological activity; The relationship of neural plasticity to the emergence of psychopathology

(1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction
Pan, Yue; Gerasimov, Madina R; Kvist, Trine; Wellendorph, Petrine; Madsen, Karsten K; Pera, Elena; Lee, Hyunbeom; Schousboe, Arne; Chebib, Mary; Brauner-Osborne, Hans; Craft, Cheryl M; Brodie, Jonathan D; Schiffer, Wynne K; Dewey, Stephen L; Miller, Steven R; Silverman, Richard B
2012-02-05; 1520-4804,Journal of medicinal chemistry - id: 150262, year: 2012

Integrating molecular imaging and behavioral neuroscience: Seeing animal models in a new light
Schiffer W.; Carrion J.; Eidelberg D.; Brodie J.D.
2012-02-05; 1536-1632,Molecular imaging & biology - id: 119244, year: 2010

Randomized, Double-Blind, Placebo-Controlled Trial of Vigabatrin for the Treatment of Cocaine Dependence in Mexican Parolees
Brodie, Jonathan D; Case, Brady G; Figueroa, Emilia; Dewey, Stephen L; Robinson, James A; Wanderling, Joseph A; Laska, Eugene M
2012-02-05; 1535-7228,American journal of psychiatry - id: 101865, year: 2009 Case Reports; Comparative Study; Journal Article; Randomized Controlled Trial

Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference
DeMarco, Amy; Dalal, Reema M; Pai, Jessica; Aquilina, Stefanie D; Mullapudi, Uma; Hammel, Crystie; Kothari, Shiva K; Kahanda, Milan; Liebling, Courtney N B; Patel, Vinal; Schiffer, Wynne K; Brodie, Jonathan D; Dewey, Stephen L
2012-02-05; 1098-2396,Synapse - id: 95221, year: 2009 Journal Article

Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
Schiffer, Wynne K; Liebling, Courtney N B; Reiszel, Corinne; Hooker, Jacob M; Brodie, Jonathan D; Dewey, Stephen L
2012-02-05; 1529-2401,Journal of neuroscience - id: 109179, year: 2009 Journal Article