Mohamed Boutjdir, Ph.D.

Activation of epsilonPKC reduces reperfusion arrhythmias and improves recovery from ischemia: Optical mapping of activation patterns in the isolated guinea-pig heart
Restivo, Mark; Kozhevnikov, Dmitry O; Qu, Yongxia S; Yue, Yuankun; Rosen, Daria-Mochly; El-Sherif, Nabil; Boutjdir, Mohamed
2012 Sep;426(2):237-241, Biochemical & biophysical research communications
— id: 179201, year: 2012, vol: 426, page: 237, stat: Journal Article,

Rescue and Worsening of Congenital Heart Block-Associated Electrocardiographic Abnormalities in Two Transgenic Mice
Karnabi E; Qu Y; Mancarella S; Boutjdir M
2011 Aug;22(8):922-930, Journal of cardiovascular electrophysiology
— id: 126653, year: 2011, vol: 22, page: 922, stat: Journal Article,

TRPC channels, an overarching Ca2+ paradigm in the developing heart
Qu Y.; Boutjdir M.
2011 ;92(2):189-190, Cardiovascular research
— id: 139759, year: 2011, vol: 92, page: 189, stat: Journal Article,

Perinatal and Postnatal Expression of Cav1.3 alpha1D Ca2+ Channel in the Rat Heart
Qu Y; Karnabi E; Ramadan O; Yue Y; Chahine M; Boutjdir M
2011 Jun;69(6):479-484, Pediatric research
— id: 126652, year: 2011, vol: 69, page: 479, stat: Journal Article,

Role of calcium channels in congenital heart block
Karnabi, E; Boutjdir, M
2010 Sep;72(3):226-234, Scandinavian journal of immunology
— id: 111594, year: 2010, vol: 72, page: 226, stat: Journal Article,

Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel
Karnabi, Eddy; Qu, Yongxia; Wadgaonkar, Raj; Mancarella, Salvatore; Yue, Yuankun; Chahine, Mohamed; Clancy, Robert M; Buyon, Jill P; Boutjdir, Mohamed
2010 Mar;34(2):80-86, Journal of autoimmunity
— id: 114633, year: 2010, vol: 34, page: 80, stat: Journal Article,

Silencing of Cav1.2 gene in neonatal cardiomyocytes by lentiviral delivered shRNA
Karnabi, Eddy; Qu, Yongxia; Mancarella, Salvatore; Yue, Yuankun; Wadgaonkar, Raj; Boutjdir, Mohamed
2009 Jul 10;384(4):409-414, Biochemical & biophysical research communications
— id: 99214, year: 2009, vol: 384, page: 409, stat: Journal Article,

PKA Activation Regulates L-type Cav1.3 Calcium Channel in vivo
Ramadan, O; Boutjdir, M
2009 NOV 3 ;120(18):S626-S626, Circulation
— id: 106975, year: 2009, vol: 120, page: S626, stat: Journal Article,

Phosphorylation of the consensus sites of protein kinase A on alpha1D L-type calcium channel
Ramadan, Omar; Qu, Yongxia; Wadgaonkar, Raj; Baroudi, Ghayath; Karnabi, Eddy; Chahine, Mohamed; Boutjdir, Mohamed
2009 Feb 20;284(8):5042-5049, Journal of biological chemistry
— id: 126654, year: 2009, vol: 284, page: 5042, stat: Journal Article,

Role of subendocardial Purkinje network in triggering torsade de pointes arrhythmia in experimental long QT syndrome
Ben Caref, E; Boutjdir, Mohamed; Himel, Herman D; El-Sherif, Nabil
2008 Oct;10(10):1218-1223, Europace
— id: 126656, year: 2008, vol: 10, page: 1218, stat: Journal Article,

Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis
Chahine, M; Qu, Y; Mancarella, S; Boutjdir, M
2008 Feb;455(5):913-919, Pflugers archiv = European journal of physiology
— id: 135309, year: 2008, vol: 455, page: 913, stat: Journal Article,

Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouse
Mancarella, Salvatore; Yue, Yuankun; Karnabi, Eddy; Qu, Yongxia; El-Sherif, Nabil; Boutjdir, Mohamed
2008 Nov;295(5):H2017-H2024, American journal of physiology. Heart & circulatory physiology
— id: 126655, year: 2008, vol: 295, page: H2017, stat: Journal Article,

Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms
Karagulova, Gulnura; Yue, Yuankun; Moreyra, Abel; Boutjdir, Mohamed; Korichneva, Irina
2007 May;321(2):517-525, Journal of pharmacology & experimental therapeutics
— id: 72809, year: 2007, vol: 321, page: 517, stat: Journal Article,

Reduction of L-type Ca2+ current results in electrocardiographic abnormalities in alpha(1D) L-type Ca2+ channel knock out mice
Mancarella, S; Yue, Y; Ou, Y; Boutjdir, M
2007 OCT 16 ;116(16):276-276, Circulation
— id: 75967, year: 2007, vol: 116, page: 276, stat: Journal Article,

The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein
Qu, Yongxia; Adler, Victor; Izotova, Lara; Pestka, Sidney; Bowne, Wilbur; Michl, Josef; Boutjdir, Mohamed; Friedman, Fred K; Pincus, Matthew R
2007 ;12:5089-5097, Frontiers in biosciences
— id: 126657, year: 2007, vol: 12, page: 5089, stat: Journal Article,

RNase protection assay for quantifying gene expression levels
Qu, Yongxia; Boutjdir, Mohamed
2007 ;366:145-158, Methods in molecular biology
— id: 126658, year: 2007, vol: 366, page: 145, stat: Journal Article,

Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes
Qu, Yongxia; Karnabi, Eddy; Chahine, Mohamed; Vassalle, Mario; Boutjdir, Mohamed
2007 Mar 30;355(1):28-33, Biochemical & biophysical research communications
— id: 126659, year: 2007, vol: 355, page: 28, stat: Journal Article,

Protein kinase C activation inhibits alpha(1D) L-type calcium channel at N-terminal serine 81 phosphorylation site
Baroudi, G; Ou, Y; Ramadan, O; Chahine, M; Boutjdir, M
2006 OCT 31 ;114(18):290-290, Circulation
— id: 69549, year: 2006, vol: 114, page: 290, stat: Journal Article,

Protein kinase C activation inhibits Cav1.3 calcium channel at NH2-terminal serine 81 phosphorylation site
Baroudi, Ghayath; Qu, Yongxia; Ramadan, Omar; Chahine, Mohamed; Boutjdir, Mohamed
2006 Oct;291(4):H1614-H1622, American journal of physiology. Heart & circulatory physiology
— id: 126660, year: 2006, vol: 291, page: H1614, stat: Journal Article,

The kinetics of spontaneous calcium oscillations and arrhythmogenesis in the in vivo heart during ischemia/reperfusion
Lakireddy, Vikram; Bub, Gil; Baweja, Paramdeep; Syed, Asma; Boutjdir, Mohamed; El-Sherif, Nabil
2006 Jan;3(1):58-66, Heart rhythm
— id: 126662, year: 2006, vol: 3, page: 58, stat: Journal Article,

Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes
Qu, Yongxia; Adler, Victor; Chu, Tearina; Platica, Ovidu; Michl, Josef; Pestka, Sidney; Izotova, Lara; Boutjdir, Mohamed; Pincus, Matthew R
2006 ;11:2420-2427, Frontiers in biosciences
— id: 126661, year: 2006, vol: 11, page: 2420, stat: Journal Article,

Protective role of protein kinase C epsilon activation in ischemia-reperfusion arrhythmia
Yue, Yuankun; Qu, Yongxia; Boutjdir, Mohamed
2006 Oct 13;349(1):432-438, Biochemical & biophysical research communications
— id: 69246, year: 2006, vol: 349, page: 432, stat: Journal Article,

Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway
Adler, Victor; Qu, Yongxia; Smith, Steven J; Izotova, Lara; Pestka, Sidney; Kung, Hsiang-Fu; Lin, Marie; Friedman, Fred K; Chie, Lyndon; Chung, Denise; Boutjdir, Mohamed; Pincus, Matthew R
2005 Aug 16;44(32):10784-10795, Biochemistry
— id: 126663, year: 2005, vol: 44, page: 10784, stat: Journal Article,

Contrasting effects of ischemia on the kinetics of membrane voltage and intracellular calcium transient underlie electrical alternans
Lakireddy, Vikram; Baweja, Paramdeep; Syed, Asma; Bub, Gil; Boutjdir, Mohamed; El-Sherif, Nabil
2005 Jan;288(1):H400-H407, American journal of physiology. Heart & circulatory physiology
— id: 126665, year: 2005, vol: 288, page: H400, stat: Journal Article,

Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia
Qu, Yongxia; Baroudi, Ghayath; Yue, Yuankun; Boutjdir, Mohamed
2005 Jun 14;111(23):3034-3041, Circulation
— id: 62392, year: 2005, vol: 111, page: 3034, stat: Journal Article,

Localization and modulation of {alpha}1D (Cav1.3) L-type Ca channel by protein kinase A
Qu, Yongxia; Baroudi, Ghayath; Yue, Yuankun; El-Sherif, Nabil; Boutjdir, Mohamed
2005 May;288(5):H2123-H2130, American journal of physiology. Heart & circulatory physiology
— id: 126664, year: 2005, vol: 288, page: H2123, stat: Journal Article,

Functional basis of sinus bradycardia in congenital heart block
Hu, Keli; Qu, Yongxia; Yue, Yuankun; Boutjdir, Mohamed
2004 Apr 5;94(4):e32-e38, Circulation research
— id: 46210, year: 2004, vol: 94, page: e32, stat: Journal Article,

Modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C
Vijayaragavan, Kausalia; Boutjdir, Mohamed; Chahine, Mohamed
2004 Apr;91(4):1556-1569, Journal of neurophysiology
— id: 126667, year: 2004, vol: 91, page: 1556, stat: Journal Article,

Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC
Yue, Yuankun; Qu, Yongxia; Boutjdir, Mohamed
2004 Feb 13;314(3):749-754, Biochemical & biophysical research communications
— id: 126666, year: 2004, vol: 314, page: 749, stat: Journal Article,

epsilon PKC inhibits human cardiac alpha(1D) (Ca(v)1.3) calcium channels
Baroudi, G; Qu, YX; Yue, YK; Boutjdir, M
2003 OCT 28 ;108(17):239-239, Circulation
— id: 42527, year: 2003, vol: 108, page: 239, stat: Journal Article,

Oncogenic and activated wild-type ras-p21 proteins induce different isoforms of protein kinase C in mitogenic signal transduction
Chie, L; Qu, YX; Chung, D; Boutjdir, M; Pincus, MR
2003 NOV ;22(7-8):625-629, Journal of protein chemistry
— id: 42575, year: 2003, vol: 22, page: 625, stat: Journal Article,

Localization and modulation of human alpha(1D) (Ca(v)1.3) L-type ca channel by protein kinase a
Qu, YX; Baroudi, G; Yue, Y; Korichneva, I; Boutjdir, M
2003 OCT 28 ;108(17):31-32, Circulation
— id: 42524, year: 2003, vol: 108, page: 31, stat: Journal Article,

alpha(1D) (Ca(v)1.3) L-type Ca channel plays a role in autoimmune-associated sinus bradycardia
Qu, YX; Yue, YK; Baroudi, G; Korichneva, I; Boutjdir, M
2003 OCT 28 ;108(17):360-360, Circulation
— id: 42528, year: 2003, vol: 108, page: 360, stat: Journal Article,

PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current
Xiao, Guang-Qian; Mochly-Rosen, Daria; Boutjdir, Mohamed
2003 Jul 11;306(4):1019-1025, Biochemical & biophysical research communications
— id: 126668, year: 2003, vol: 306, page: 1019, stat: Journal Article,

Cardiac 5-HT(4) Serotoninergic Receptors, 52kD SSA/Ro and Autoimmune-Associated Congenital Heart Block
Buyon, Jill P; Clancy, Robert; Di Donato, Francis; Miranda-Carus, M Eugenia; Askanase, Anca D; Garcia, Joanne; Qu, Yongxia; Hu, Keli; Yue, Yuankun; Chan, Edward K L; Boutjdir, Mohamed
2002 Aug;19(1-2):79-86, Journal of autoimmunity
— id: 32693, year: 2002, vol: 19, page: 79, stat: Journal Article,

Cardiac 5-HT4 serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block
Boutjdir, M; Qu, YX; Hu, KL; Di Donato, F; Miranda-Carus, E; Askanase, AD; Garcia, J; Chan, EK; Buyon, JP
2001 OCT 23 ;104(17):752-752, Circulation
— id: 54805, year: 2001, vol: 104, page: 752, stat: Journal Article,

Anti-re-associated sinus bradycardia in newborns - Response
Boutjdir, M; El-Sherif, N; Mazel, JA
2000 SEP 12 ;102(11):E88-E89, Circulation
— id: 54529, year: 2000, vol: 102, page: E88, stat: Journal Article,

mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure
Tseng CE; Miranda E; Di Donato F; Boutjdir M; Rashbaum W; Chan EK; Buyon JP
1999 Feb;45(2):260-269, Pediatric research
— id: 57078, year: 1999, vol: 45, page: 260, stat: Journal Article,

Serum and immunoglobulin G from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model
Boutjdir M; Chen L; Zhang ZH; Tseng CE; El-Sherif N; Buyon JP
1998 Jul;44(1):11-19, Pediatric research
— id: 12093, year: 1998, vol: 44, page: 11, stat: Journal Article,

Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
Miranda-Carus ME; Boutjdir M; Tseng CE; DiDonato F; Chan EK; Buyon JP
1998 Dec 1;161(11):5886-5892, Journal of immunology
— id: 7686, year: 1998, vol: 161, page: 5886, stat: Journal Article,

Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
Miranda-Carus, ME; Boutjdir, M; Tseng, C; DiDonato, F; Chan, EKL; Buyon, JP
1998 MAR ;46(3):234A-234A, Journal of investigative medicine
— id: 53504, year: 1998, vol: 46, page: 234A, stat: Journal Article,

Arrhythmogenicity of IgG and anti-52-kD SSA/Ro affinity-purified antibodies from mothers of children with congenital heart block
Boutjdir, M; Chen, L; Zhang, Z H; Tseng, C E; DiDonato, F; Rashbaum, W; Morris, A; el-Sherif, N; Buyon, J P
1997 Mar;80(3):354-362, Circulation research
— id: 73556, year: 1997, vol: 80, page: 354, stat: Journal Article,

Arrhythmogenicity of IgG from mothers of children with congenital heart block
Boutjdir, M; Chen, L; Zhang, ZH; Tseng, C; DiDonato, F; ElSherif, N; Buyon, J
1996 OCT 15 ;94(8):4175-4175, Circulation
— id: 52748, year: 1996, vol: 94, page: 4175, stat: Journal Article,

IgG and affinity purified anti-52kD SSA/Ro antibodies from mothers of children with congenital heart block induce conduction defects and inhibit Ca channels in the human fetal heart
Boutjdir, M; Chen, L; Zhang, ZH; Tseng, C; DiDonato, F; Rashburn, W; Morris, W; ElSherif, N; Buyon, J
1996 OCT 15 ;94(8):3471-3471, Circulation
— id: 52747, year: 1996, vol: 94, page: 3471, stat: Journal Article,

ELECTROPHYSIOLOGIC CHARACTERIZATION OF PURIFIED IGG FROM A MOTHER WHOSE CHILD HAS CONGENITAL HEART-BLOCK (CHB) ON L-TYPE CALCIUM CURRENTS (I-CA)
BOUTJDIR, M; ZHANG, ZH; CHEN, L; ELSHERIF, N; TSENG, CE; DIDONATO, F; RASHBAUM, W; BUYON, JP
1995 SEP ;38(9):466-466, Arthritis & rheumatism
— id: 86695, year: 1995, vol: 38, page: 466, stat: Journal Article,