Natalie Borodoker, M.D.

Indocyanine green angiography findings in Sorsby's pseudoinflammatory maculopathy
Borodoker, N; Yannuzzi, LA
2005 JUN 15 ;46(12):7894-7903, Investigative ophthalmology & visual science. IOVS
— id: 56198, year: 2005, vol: 46, page: 7894, stat: Journal Article,

Imaging techniques for posterior uveitis
Ciardella, Antonio P; Prall, F Ryan; Borodoker, N; Cunningham, Emmett T Jr
2004 Dec;15(6):519-530, Current opinion in ophthalmology
PURPOSE OF REVIEW: The goal of this review is to describe the more commonly used imaging techniques and their use to identify causes of vision loss, extent of disease, and distinctive patterns associated with various causes of posterior uveitis. RECENT FINDINGS: Distinctive patterns seen with new imaging techniques and applications are being described. Ophthalmic CT, fluorescein angiography, indocyanine green angiography, and others are demonstrating inflammation and pathology in posterior uveitis. As our experience grows with these modalities, they are being used increasingly in the diagnosis and management of patients with posterior uveitis. SUMMARY: This review familiarizes the ophthalmologist with imaging in patients with inflammatory disorders of the retina and choroid. These modalities can help with the diagnosis, treatment, and monitoring of patients with uveitis
— id: 74643, year: 2004, vol: 15, page: 519, stat: Journal Article,

Cystoid macular degeneration in chronic central serous chorioretinopathy
Iida, Tomohiro; Yannuzzi, Lawrence A; Spaide, Richard F; Borodoker, Natalie; Carvalho, Cynthia A; Negrao, Silvana
2003 Feb;23(1):1-7, Retina
PURPOSE: To describe the optical coherence tomography (OCT) and fluorescein angiography findings in the macula of eyes with chronic central serous chorioretinopathy (CSC) and reduced central vision. METHODS: Using OCT, clinical examination, and fluorescein and indocyanine green (ICG) angiography, the authors examined eight eyes of seven patients with CSC, an attached macula, and reduced central vision of 20/200 or worse. All had a history of chronic CSC with resolution of the subretinal fluid in the macular area and poor vision. RESULTS: Patient ages ranged from 55 to 82 years (mean, 66 years). All eight eyes had some parafoveal, patchy RPE atrophy with corresponding transmission hyperfluorescence (window defect) on fluorescein angiography. Five eyes also had a window defect in the foveal area. With OCT, the foveal area revealed variable areas of cystoid change and atrophy in seven of the eight eyes. In four of these eyes, the cystoid changes were not seen on clinical examination or fluorescein angiography. The seven eyes with cystoid changes imaged with OCT had no intraretinal leakage of fluorescein in the foveal region. The authors categorized these eyes as having cystoid macular degeneration (CMD). One other eye had foveal thinning or atrophy without cystoid changes. CONCLUSIONS: Intraretinal cystoid spaces without intraretinal leakage, or CMD, was a common finding in eyes with chronic CSC and reduced central vision after resolution of subretinal fluid. OCT was useful to establish the presence of CMD and foveal atrophy, even when these changes were not clearly evident on clinical examination or fluorescein angiography. Chronic foveal detachment and antecedent intraretinal leakage were proposed to be the mechanisms for the development of the changes. CMD in conjunction with foveal atrophy was an important clinical finding to account for the poor visual outcome in patients with CSC
— id: 103434, year: 2003, vol: 23, page: 1, stat: Journal Article,

Polypoidal choroidal vasculopathy and limited choroidal hemorrhage following cataract surgery
Borodoker, N; Rodriguez-Coleman, H; Ciardello, AP; Shields, CL; Shields, JA; Donsoff, I; Yannuzzi, LA
2002 ;43(7):1217-1217, Investigative ophthalmology & visual science. IOVS
— id: 103704, year: 2002, vol: 43, page: 1217, stat: Journal Article,

Peripheral curvilinear pigmentary streak in multifocal choroiditis
Borodoker, Natalie; Cunningham, Emmett T Jr; Yannuzzi, Lawrence A; Nicoletti, Renato
2002 Apr;120(4):520-521, Archives of ophthalmology
— id: 74654, year: 2002, vol: 120, page: 520, stat: Journal Article,

Retinopathy as a result of long-term use of thioridazine
Borodoker, Natalie; Del Priore, Lucian V; De A Carvalho, Cynthia; Yannuzzi, Lawrence A
2002 Jul;120(7):994-995, Archives of ophthalmology
— id: 103443, year: 2002, vol: 120, page: 994, stat: Journal Article,

Verteporfin infusion-associated pain
Borodoker, Natalie; Spaide, Richard F; Maranan, Leandro; Murray, Jane; Freund, K Bailey; Slakter, Jason S; Sorenson, John A; Yannuzzi, Lawrence A; Guyer, David R; Fisher, Yale L
2002 Feb;133(2):211-214, American journal of ophthalmology
PURPOSE: To determine if oral hydration decreases the incidence of verteporfin infusion-associated pain and to find out if other factors play a role in predisposing to this undesired complication. METHODS: Nonrandomized clinical trial. We prospectively examined 250 consecutive patients who have been diagnosed with subfoveal choroidal neovascularization secondary to age-related macular degeneration and received photodynamic therapy using verteporfin. One hundred twenty-five patients were assigned to receive 500 ml of water orally administered 30 minutes before beginning the verteporfin infusion, and the remaining 125 consecutive patients were used as controls. Historical and clinical factors in these patients were evaluated for their association with the presence of verteporfin infusion-associated pain. RESULTS: Out of 125 patients receiving water before treatment 12 (9.6%) experienced verteporfin infusion-associated pain. Among the 125 patients who did not get hydration before therapy 12(9.6%) experienced verteporfin infusion-associated pain. There was no statistical difference between the incidence of pain in the two groups (P = 1.0). No statistically significant association was evidenced between the presence of pain and participant's baseline characteristics, except for pain on previous administration of verteporfin (P < .001). Out of 250 total patients 24 (9.6%) developed verteporfin infusion-associated pain. Back pain was the most common and occurred in 21 (8.4%) patients, but other sites included leg, groin, chest, buttock, arm, and shoulder pain concurrently or independently. All patients had resolution of their pain, including chest pain, on cessation of the infusion. CONCLUSIONS: Verteporfin infusion-associated pain may be more common than has been previously reported and is not limited to the back area. It appears to be an idiosyncratic reaction to the drug. It does not seem to be prevented by oral hydration before infusion of verteporfin, and no baseline characteristics, other than a history of pain on previous infusion, seem to be predictive of verteporfin infusion-associated pain
— id: 27094, year: 2002, vol: 133, page: 211, stat: Journal Article,

Imaging the posterior segment in uveitis
Ciardella, Antonio P; Borodoker, Natalie; Costa, Danielle L; Huang, Sheau J; Cunningham, Emmett T Jr; Slakter, Jason S
2002 Sep;15(3):281-96, v, Ophthalmology clinics of North America
This article reviews established and newly developed posterior segment imaging techniques that may be helpful in the diagnosis and management of patients with uveitis. A brief description of various techniques is followed by a discussion of the situations in which these techniques might be useful in assessing the cause of vision loss, and the extent and activity of the inflammatory changes. The last section of the article describes selected uveitis syndromes wherein posterior segment imaging can reveal diagnostically characteristic, and in some instances pathognomonic, findings
— id: 74652, year: 2002, vol: 15, page: 281, stat: Journal Article,

Crystalline retinopathy associated with retinal dialysis and chronic retinal detachment
Ciardella, Antonio P; Yannuzzi, Lawrence A; Borodoker, Natalie; Mendoza, Caroline
2002 Jun;22(3):360-362, Retina
— id: 103444, year: 2002, vol: 22, page: 360, stat: Journal Article,

Motion Ophthalmoscopy Macula (MOM)
Ciardella, AP; Hathiromani, S; Orlock, D; Borodoker, N; Yannuzzi, LA
2002 ;43(3):4340-4340, Investigative ophthalmology & visual science. IOVS
— id: 103705, year: 2002, vol: 43, page: 4340, stat: Journal Article,

Chronic central serous chorioretinopathy presenting with peripheral lipid exudation
Donsoff, IM; Ciardella, AP; Costa, DLL; Huang, SJ; Borodoker, N; Marmor, MF; Yannuzzi, LA
2002 ;43(2):491-491, Investigative ophthalmology & visual science. IOVS
— id: 103707, year: 2002, vol: 43, page: 491, stat: Journal Article,

Photodynamic Therapy for Extrafoveal and Juxtafoveal Choroidal Neovascularization
Huang, S. J.; Del Priore, L. V.; Mendoza, C.; Slakter, J. S.; Spaide, R. F.; Freund, B.; Sorenson, J. A.; Costa, D. L. L.; Borodoker, N.; Yannuzzi, L. A.
2002 ;2002(5):Abstract No. 581-Abstract No. 581, ARVO Annual Meeting Abstract Search & Program Planner
Purpose: To determine the efficacy of photodynamic therapy (PDT) for juxtafoveal or extrafoveal lesions with mainly classic components in age-Related macular degeneration (AMD) and other disorders, in which treating surgeon deferred thermal laser to avoid scotoma. Methods: Retrospective review of pretreatment fluorescein angiograms from April 2000 to December 2001 in a large multiphysician retina practice. Results: Forty-one eyes of 40 patients were reviewed. Age ranged from 35 to 94 (mean =72.2). Treated diseases included: AMD (27 eyes, 65.9%), myopic degeneration (5 eyes, 12.2%), multifocal choroiditis (MFC) (3 eyes of 2 patients, 7.3%), polypoidal choroidal vasculopathy (PCV) (2 eyes, 4.9%), retinal angiomatous proliferation (RAP) (2 eyes, 4.9%), presumed ocular histoplasmosis syndrome (POHS) (1 eye, 2.4%) and idiopathic choroidal neovascularization (ICNV) (1 eye, 2.4%). Pretreatment CNV was predominantly classic in 32 eyes (78%); location was juxtafoveal in 31 eyes (76%) and extrafoveal in 10 eyes (24%). Initial best-corrected Snellen acuity (VA) ranged from 20/25 to 20/1600 (mean =20/200) and final VA ranged from 20/20 to 20/1600 (mean =20/200). The number of treatments ranged from 1 to 6 (mean = 2.4). VA improved by 2 or more lines in 12 eyes (29%), stabilized in 14 (34 %), and decreased 2 or more lines in 15 (37 %). Final VA was 20/100 or better in 19 eyes, including 12 eyes with AMD (44% of original 27 eyes), 2 (40%) with myopic degeneration, 2 (67%) with MFC, 1 (50%) with PCV, 1 (50%) with RAP, 1 (100%) with POHS, and 1 (100%) with ICNV. Conclusion: Treatment of extrafoveal and juxtafoveal lesions with PDT is associated with partial stabilization and improvement of visual acuity in some cases. Approximately 40% of patients with AMD and myopic degeneration achieve a final vision > 20/100. Further research is required to determine the prognosis and response to PDT of patients with extrafoveal and juxtafoveal choroidal neovascularization
— id: 103637, year: 2002, vol: 2002, page: Abstract No. 581, stat: Journal Article,

Photodynamic therapy for extrafoveal and juxtafoveal choroidal neovascularization
Huang, SJ; Del Priore, LV; Mendoza, C; Slakter, JS; Spaide, RF; Freund, B; Sorensen, JA; Costa, DLL; Borodoker, N; Yannuzzi, LA
2002 ;43(5):581-581, Investigative ophthalmology & visual science. IOVS
— id: 103638, year: 2002, vol: 43, page: 581, stat: Journal Article,

Atypical choroidal neovascularization in radiation retinopathy
Spaide, Richard F; Borodoker, Natalie; Shah, Viral
2002 May;133(5):709-711, American journal of ophthalmology
PURPOSE: To report atypical choroidal neovascularization associated with radiation retinopathy. DESIGN: Case report. METHODS: The patient was examined with ophthalmoscopy, fluorescein angiography, and indocyanine green angiography. RESULTS: A 32-year-old woman presented with an accelerated course of radiation retinopathy with macular edema, capillary telangiectasis, subretinal fluid, and lipid during and after pregnancy. Indocyanine green, but not fluorescein angiography, demonstrated an unusual area of choroidal neovascularization with prominent saccular dilations adjacent to a large zone of poor choroidal perfusion. Laser photocoagulation of the choroidal neovascularization resulted in an angiographic closure with absorption of the subretinal fluid and improvement of visual acuity. CONCLUSIONS: Choroidal neovascularization may be associated with radiation retinopathy and, when present, may require indocyanine green angiography for its diagnosis
— id: 103529, year: 2002, vol: 133, page: 709, stat: Journal Article,

Retinal angiomatous proliferation in age-related macular degeneration
Yannuzzi, L A; Negrao, S; Iida, T; Carvalho, C; Rodriguez-Coleman, H; Slakter, J; Freund, K B; Sorenson, J; Orlock, D; Borodoker, N
2001 ;21(5):416-434, Retina
BACKGROUND: It is known that choroidal neovascularization (CNV) in age-related macular degeneration (ARMD) may erode through the retinal pigment epithelium, infiltrate the neurosensory retina, and communicate with the retinal circulation in what has been referred to as a retinal-choroidal anastomosis (RCA). This is extremely common in the end stage of disciform disease. In recent years, the reverse also seems to be possible, as angiomatous proliferation originates from the retina and extends posteriorly into the subretinal space, eventually communicating in some cases with choroidal new vessels. This form of neovascular ARMD, termed retinal angiomatous proliferation (RAP) in this article, can be confused with CNV. PURPOSE: The purpose of this article is 1) to review the clinical and angiographic characteristics of a series of patients with RAP and 2) to propose a theoretical sequence of events that accounts for the neovascularized process. METHODS: In this retrospective clinical and angiographic analysis, 143 eyes with RAP (108 patients) were reviewed and classified based on their vasogenic nature and course. Clinical biomicroscopic examination, fluorescein angiography, and indocyanine green angiography were used to evaluate patients. RESULTS: The results of this series suggest that angiomatous proliferation within the retina is the first manifestation of the vasogenic process in this form of neovascular ARMD. Dilated retinal vessels and pre-, intra-, and subretinal hemorrhages and exudate evolve, surrounding the angiomatous proliferation as the process extends into the deep retina and subretinal space. One or more dilated compensatory retinal vessels perfuse and drain the neovascularization, sometimes forming a retinal-retinal anastomosis. Fluorescein angiography in these patients usually revealed indistinct staining simulating occult CNV. Indocyanine green angiography was useful to make an accurate diagnosis in most cases. It revealed a focal area of intense hyperfluorescence corresponding to the neovascularization ('hot spot') and other characteristic findings. Based on understanding of the nature and progression of the neovascularized process, patients with RAP were classified into three vasogenic stages. Stage I involved proliferation of intraretinal capillaries originating from the deep retinal complex (intraretinal neovascularization [IRN]). Stage II was determined by growth of the retinal vessels into the subretinal space (subretinal neovascularization [SRN]). Stage III occurred when CNV could clearly be determined clinically or angiographically. A vascularized pigment epithelial detachment and RCA were inconsistent features of this stage. CONCLUSIONS: Retinal angiomatous proliferation appears to be a distinct subgroup of neovascular ARMD. It may present in one of three vasogenic stages: IRN, SRN, or CNV. Whereas ICG angiography is helpful in diagnosing RAP and in documenting the stage of the neovascularized process, it is frequently difficult to determine the precise nature and location of the new vessel formation. It is important for clinicians to recognize the vasogenic potential and the associated manifestations of this peculiar form of neovascular ARMD so that a proper diagnosis can be made, and when possible, an appropriate management administered
— id: 103399, year: 2001, vol: 21, page: 416, stat: Journal Article,