Manfred Blum

Biosketch / Results /

Manfred Blum, M.D.

Professor;
Departments of Medicine (Endocrinology Div) and Radiology (Nuclear Medicine)
NYU Radiology Associates

Clinical Addresses

530 FIRST AVENUE, HCC 4E
SCHWARTZ EAST ELEVATORS
NEW YORK, NY 10016
Hours: Mon. 1 - 7; Tue. 10 - 1; Wed. 1 - 7; Thu. 4 - 7
Handicap Access: yes
Phone: 212-263-7444
Fax: 212-263-0401

Medical Specialties

Endocrinology & Metabolism, Internal Medicine

Medical Expertise

Thyroid Cancer, Gen Endocrinology/Metabolism, Parathyroid Disorders, Adrenal Disorders, Pituitary Disorders, Thyroid Disease

Clinical Responsibilities

Dr. Blum is the Director of the Thyroid Unit and Nuclear Endocrinology division. He also has a consultation practice in endocrinology, specializing in thyroid disorders, located in our Faculty Practice Offices.

Dr. Blum is a former Treasurer of The American Thyroid Association.

Languages

German

Board Certification

1974 — Ab Internal Medicine - Internal Medicine
1975 — Ab Internal Medicine (Endocrinology, Diabetes & Metabolism)

Education

1953-1957 — New York University School of Medicine, Medical Education
1957-1958 — Bellevue Hospital Center (Medicine), Internship
1958-1959 — Montefiore Medical Center (Medicine), Residency Training
1959-1960 — Bellevue Hospital Center (Medicine), Residency Training
1960-1961 — Beth Israel Hospital (Endocrinology), Clinical Fellowships

Research Summary

Dr Blum has been innovative in investigating and providing a clinical service for imaging thyroid nodules to identify cancers, to localize and treat metastatic thyroid cancers with I-131 after thyroidectomy, and to diagnose and treat hyperthyroidism.
The diagnosis and treatment of thyroid tumors has evolved as a translation of advances in science and technology. Nodules are extremely common in diffusely enlarged and in normal size thyroid glands. Before the mid 1960?s clinicians erroneously acted as if many of the nodules were aggressive cancers and most patients with a thyroid mass were referred for surgery. Subsequently clinical investigation revealed that cancer was uncommon and for most patients the significant surgical risks were not warranted. It became a major challenge to identify and remove the 20,000 cancers that are seen in the United States yearly among the 5% of the population who have a palpable thyroid nodule and the 50% of people who have nodules that are detectable by ultrasound, and to avoid unnecessary surgery.
In the last 3 decades Dr. Blum's laboratory pioneered and improved imaging techniques including isotope scanning, ultrasonography, and ultrasound-guided fine-needle percutaneous aspiration biopsy to provide essential information that has allowed surgery to be restricted to the less than 1% of nodule patients who are the most likely to have cancer. Dr. Blum among was among the earliest investigators of thyroid ultrasonography in the 1970's and together with students, residents, and fellows he developed novel and clinically useful approaches to thyroid imaging, publishing 21 papers, 3 editorials, 11 textbook chapters, and 18 oral presentations at national meetings about this subject, among more than 90 publications about other Endocrine and Nuclear Medicine subjects.

Research Interests

Director of the NYU Thyroid Unit Dr. Blum continues to study thyroid nodules and cancer. In addition, he now participates with Dr. Martin Blaser in investigating whether the microbiome plays a role in the pathogenesis, natural history, or clinical manifestations of Hashimoto's and/or Graves' diseases.

Research Keywords

thyroid ultrasound, thyroid sonography, thyroid scintigraphy, thyroid nodules, thyroid cancer, hyperthyroidism

All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

I-131 SPECT/CT Elucidates Cryptic Findings on Planar Whole-Body Scans and Can Reduce Needless Therapy with I-131 in Post-Thyroidectomy Thyroid Cancer Patients
Blum, Manfred; Tiu, Serafin; Chu, Michael; Goel, Sumina; Friedman, Kent
2011 Nov;21(11):1235-1247, Thyroid
— id: 141075, year: 2011, vol: 21, page: 1235, stat: Journal Article,

Lithium carbonate use may enhance hypercalcemia in a patient with primary hyperparathyroidism
Huberman, D T; Blum, M
2011 June 2011;32(3):-, Endocrine reviews
— id: 159279, year: 2011, vol: 32, page: , stat: Journal Article,

Radioactivity of blood samples taken from thyroidectomized thyroid carcinoma patients after therapy with (131)i
Larkin, Ann; Millan, Evelyn; Noz, Marilyn; Wagner, Steve; Friedman, Kent; Blum, Manfred
2011 Sep;21(9):1009-1012, Thyroid
— id: 137003, year: 2011, vol: 21, page: 1009, stat: Journal Article,

Somatostatin receptor scintigraphy as a potential diagnostic and treatment modality for thyroid follicular-cell-derived cancers
Margulies, Debra J; Blum, Manfred
2010 Jun;20(6):671-672, Thyroid
— id: 134421, year: 2010, vol: 20, page: 671, stat: Journal Article,

Ultrasonic imaging and identification of metastases in cervical lymph nodes
Blum, Manfred
Thyroid cancer : a comprehensive guide to clinical management Totowa, N.J. : Humana Press, c2006,
— id: 845852, year: 2006, vol: , page: 351, stat: Chapter,

Ultrasonic imaging of the neck in patients with thyroid cancer
Blum, Manfred
Thyroid cancer : a comprehensive guide to clinical management Totowa, N.J. : Humana Press, c2006,
— id: 845862, year: 2006, vol: , page: 229, stat: Chapter,

Alert: 6-mercaptopurine may be erroneously dispensed instead of propylthiouracil
Blum, Manfred; Peck, Valerie; Seltzer, Terry; Goldberg-Berman, Judith
2005 Nov;15(11):1315-1315, Thyroid
— id: 95170, year: 2005, vol: 15, page: 1315, stat: Journal Article,

Control of hypertension and dyslipidemia are linked in a hypertension specialist clinic
Singer, GM; Chua, DY; Setaro, JF; Foody, JM; Blum, MS; Black, HR
2005 ;18(5):150A-151A, American journal of hypertension
— id: 109448, year: 2005, vol: 18, page: 150A, stat: Journal Article,

Evidence and thoughts about thyroid nodules that grow after they have been identified as benign by aspiration cytology
Blum, Manfred; Hussain, Mehboob A
2003 Jul;13(7):637-641, Thyroid
— id: 39083, year: 2003, vol: 13, page: 637, stat: Journal Article,

Pinhole vs. parallel hole collimator SPECT of the thyroid. Phantom acquisitions
Smith, KF; Matthew, KJ; Davis, JM; Landsman, DZ; Noz, ME; Blum, M; Kramer, EL
2002 May;43(5):1294-, Journal of nuclear medicine
— id: 28191, year: 2002, vol: 43, page: 1294, stat: Journal Article,

Thyrotoxicosis after interferon-alpha therapy
Csaki AC; Blum M
2000 Jan;10(1):101-101, Thyroid
— id: 27852, year: 2000, vol: 10, page: 101, stat: Journal Article,

No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase beta
Harroch S; Palmeri M; Rosenbluth J; Custer A; Okigaki M; Shrager P; Blum M; Buxbaum JD; Schlessinger J
2000 Oct 15;20(20):7706-7715, Molecular & cellular biology
— id: 11490, year: 2000, vol: 20, page: 7706, stat: Journal Article,

Why do clinicians continue to debate the use of levothyroxine in the diagnosis and management of thyroid nodules?
Blum M
1995 Jan 1;122(1):63-64, Annals of internal medicine
— id: 6580, year: 1995, vol: 122, page: 63, stat: Journal Article,

Reducing suppressive therapy in patients with a history of thyroid cancer
Blum M; Perlman S
1995 Nov 15;123(10):808-809, Annals of internal medicine
— id: 30812, year: 1995, vol: 123, page: 808, stat: Journal Article,

Primary hyperparathyroidism associated with two enlarged parathyroid glands
Roses DF; Karp NS; Sudarsky LA; Valensi QJ; Rosen RJ; Blum M
1989 Nov;124(11):1261-1265, Archives of Surgery (Chicago)
— id: 10429, year: 1989, vol: 124, page: 1261, stat: Journal Article,

The use of preoperative localization of adenomas of the parathyroid glands by thallium-technetium subtraction scintigraphy, high-resolution ultrasonography and computed tomography
Roses DF; Sudarsky LA; Sanger J; Raghavendra BN; Reede DL; Blum M
1989 Feb;168(2):99-106, Surgery, gynecology & obstetrics
— id: 10738, year: 1989, vol: 168, page: 99, stat: Journal Article,

STIMULATION OF PITUITARY LUTEINIZING-HORMONE SECRETION BY GONADOTROPIN-RELEASING HORMONE IS NOT COUPLED TO BETA-LUTEINIZING HORMONE GENE-TRANSCRIPTION
SALTON, SRJ; BLUM, M; JONASSEN, JA; CLAYTON, RN; ROBERTS, JL
1988 NOV ;2(11):1033-1042, Molecular endocrinology
— id: 41755, year: 1988, vol: 2, page: 1033, stat: Journal Article,

Immunoradiometric (IRMA) assay for thyrotropin (TSH) should replace the RIA method in the clinical laboratory
Rosenfeld, L; Blum, M
1986 Jan;32(1 Pt 1):232-233, Clinical chemistry
— id: 802322, year: 1986, vol: 32, page: 232, stat: Journal Article,

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome
Greene LW; Cole W; Levy B; Louie E; Raphael B; Waitkevicz HJ; Blum M
1985 ;:289-291, Year book of endocrinology
— id: 36582, year: 1985, vol: , page: 289, stat: Journal Article,

CLINICAL SUPERIORITY OF A HIGH-SENSITIVITY MONOCLONAL IMMUNORADIOMETRIC ASSAY (IRMA) FOR HUMAN THYROID-STIMULATING HORMONE (TSH)
Rosenfeld, L; Blum, M
1985 ;31(6):953-953, Clinical chemistry
— id: 30901, year: 1985, vol: 31, page: 953, stat: Journal Article,

Computerized axial tomography in the diagnosis and management of thyroid and parathyroid disorders
Blum M; Reede DL; Seltzer TF; Burroughs VJ; Greene LW; Roses DF
1984 Jan-Feb;287(1):34-39, American journal of the medical sciences
— id: 25107, year: 1984, vol: 287, page: 34, stat: Journal Article,

THE DIAGNOSIS OF THE THYROID-NODULE USING ASPIRATION BIOPSY AND CYTOLOGY
BLUM, M
1984 ;144(6):1140-1142, Archives of internal medicine
— id: 50874, year: 1984, vol: 144, page: 1140, stat: Journal Article,

Martial-arts thyroiditis
Blum, M; Schloss, M F
1984 Jul;311(3):199-200, New England journal of medicine
— id: 703832, year: 1984, vol: 311, page: 199, stat: Journal Article,

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome
Greene LW; Cole W; Greene JB; Levy B; Louie E; Raphael B; Waitkevicz J; Blum M
1984 Oct;101(4):497-498, Annals of internal medicine
— id: 36564, year: 1984, vol: 101, page: 497, stat: Journal Article,

PROPRANOLOL-ASSOCIATED HYPOGLYCEMIA - REPLY
BLUM, M; RUOFF, M
1983 ;309(21):1327-1328, New England journal of medicine
— id: 40601, year: 1983, vol: 309, page: 1327, stat: Journal Article,

Response to hypoglycemia masked by propranolol
Blum, M; Ruoff, M
1983 Jul;309(2):112-113, New England journal of medicine
— id: 563902, year: 1983, vol: 309, page: 112, stat: Journal Article,

RADIATION-DOSE ESTIMATES TO LARYNGEAL NERVE AS A RESULT OF I-131 TREATMENT FOR HYPERTHYROIDISM
CHANDRA, R; GREENE, L; BLUM, M
1983 ;10(5):732-732, Medical physics
— id: 40615, year: 1983, vol: 10, page: 732, stat: Journal Article,

Carcinoma of the thyroglossal duct
Roses DF; Snively SL; Phelps RG; Cohen N; Blum M
1983 Feb;145(2):266-269, American journal of surgery
— id: 25108, year: 1983, vol: 145, page: 266, stat: Journal Article,

Thyroglossal duct carcinoma
Blum M; Roses DF; Cohen C
1982 Aug 27;248(8):924-924, JAMA
— id: 25109, year: 1982, vol: 248, page: 924, stat: Journal Article,

Evaluation of euthyroid solitary. Autonomous nodule of the thyroid gland. Importance of scintillation scanning and thyrotropin-releasing hormone testing
Blum, M; Seltzer, T F; Campbell, C C; Burroughs, V J
1982 Apr;247(14):1991-1993, JAMA
— id: 734392, year: 1982, vol: 247, page: 1991, stat: Journal Article,

Intrathoracic goiter. Diagnosis by ultrasound
Toder, S P; Raghavendra, B N; Blum, M; McCauley, D I
1982 Feb;82(2):230-231, New York state journal of medicine
— id: 124455, year: 1982, vol: 82, page: 230, stat: Journal Article,

Painless thyroiditis: diagnostic essentials
Burroughs, V J; Seltzer, T F; Blum, M
1981 Jul;246(1):39-40, JAMA
— id: 734402, year: 1981, vol: 246, page: 39, stat: Journal Article,

Easy bruising, thrombocytopenia, and elevated platelet immunoglobulin G in Graves' disease and Hashimoto's thyroiditis
Hymes K; Blum M; Lackner H; Karpatkin S
1981 Jan;94(1):27-30, Annals of internal medicine
— id: 14953, year: 1981, vol: 94, page: 27, stat: Journal Article,

Vaginal sensations after injection of thyrotropin releasing hormone
Blum, M; Pulini, M
1980 Jul;2(8184):43-43, Lancet
— id: 577772, year: 1980, vol: 2, page: 43, stat: Journal Article,

IMPROVED NONOPERATIVE DIAGNOSIS OF THE SOLITARY COLD THYROID- NODULE - SURGICAL SELECTION BASED ON RISK-FACTORS AND 3 MONTHS OF SUPPRESSION
Blum, M; Rothschild, M
1980 ;243(3):242-245, JAMA
— id: 28080, year: 1980, vol: 243, page: 242, stat: Journal Article,

THE SOLITARY THYROID-NODULE - REPLY
Blum, M; Rothschild, M
1980 ;244(22):2520-2520, JAMA
— id: 27942, year: 1980, vol: 244, page: 2520, stat: Journal Article,

EASY BRUISING, THROMBOCYTOPENIA AND ELEVATED PLATELET IGG IN GRAVES-DISEASE AND HASHIMOTO THYROIDITIS
Hymes, K; Blum, M; Lackner, H; Karpatkin, S
1980 ;28(2):A349-A349, Clinical research
— id: 28112, year: 1980, vol: 28, page: A349, stat: Journal Article,

Why the high background? [75Se] L-selenomethionine--a longterm culprit
Blum M; Harley NH; Kolber AB; Melnikoff L; Bailey M
1979 Apr;20(4):365-366, Journal of nuclear medicine
— id: 20281, year: 1979, vol: 20, page: 365, stat: Journal Article,

Clinical implications of the rare thyroid carcinoma which is indistinguishable from a follicular adenoma
Blum, M; Feiner, H D; Worth, M H; King, L W
1978 Jul-Aug;276(1):99-104, American journal of the medical sciences
— id: 167525, year: 1978, vol: 276, page: 99, stat: Journal Article,

MANAGING SOLITARY THYROID NODULE - ECHOGRAPHYS ROLE
BLUM, M; PASSALAQUA, AM
1978 ;13(2):65-72, Hospital practice (office edition)
— id: 40050, year: 1978, vol: 13, page: 65, stat: Journal Article,

Dialysance of iodide
Blum, M; Spinowitz, B; Gombos, E A
1978 Jul 20;299(3):154-154, New England journal of medicine
— id: 78182, year: 1978, vol: 299, page: 154, stat: Journal Article,

Management of the solitary thyroid nodule : a select approach
Blum, Manfred
1978 ;1(9):1-6, Thyroid today
— id: 106610, year: 1978, vol: 1, page: 1, stat: Journal Article,

HEPATIC VISUALIZATION AFTER I-131 IN PATIENTS WITH THYROID- CARCINOMA (CONT)
Blum, M
1977 ;296(11):634-634, New England journal of medicine
— id: 29622, year: 1977, vol: 296, page: 634, stat: Journal Article,

MANAGING SOLITARY THYROID NODULE - ROLE OF NEEDLE-BIOPSY
BLUM, M
1977 ;87(3):375-377, Annals of internal medicine
— id: 39940, year: 1977, vol: 87, page: 375, stat: Journal Article,

THYROID NODULE WITH CONTRALATERAL EXOPHTHALMOS
BLUM, M
1977 ;238(16):1769-1770, JAMA
— id: 39936, year: 1977, vol: 238, page: 1769, stat: Journal Article,

Reversible hypertension. Caused by the hypercalcemia of hyperparathyroidism, vitamin D toxicity, and calcium infusion
Blum, M; Kirsten, M; Worth, M H Jr
1977 Jan;237(3):262-263, JAMA
— id: 167526, year: 1977, vol: 237, page: 262, stat: Journal Article,

SPECTRUM OF DISEASES OF THYROID-GLAND AS IMAGED BY GRAY SCALE WATER BATH SONOGRAPHY
SACKLER, JP; PASSALAQUA, AM; BLUM, M; AMOROCHO, L
1977 ;125(2):467-472, Radiology
— id: 39927, year: 1977, vol: 125, page: 467, stat: Journal Article,

THYROID STORM AFTER CARDIAC ANGIOGRAPHY WITH IODINATED CONTRAST-MEDIUM - OCCURRENCE IN A PATIENT WITH A PREVIOUSLY EUTHYROID AUTONOMOUS NODULE OF THYROID
Blum, M; Kranjac, T; Park, CM; Engleman, RM
1976 ;235(21):2324-2325, JAMA
— id: 28767, year: 1976, vol: 235, page: 2324, stat: Journal Article,

The autonomous nodule of the thyroid: correlation of patient age, nodule size and functional status
Blum M; Shenkman L; Hollander CS
1975 Jan-Feb;269(1):43-50, American journal of the medical sciences
— id: 29286, year: 1975, vol: 269, page: 43, stat: Journal Article,

ENHANCED CLINICAL DIAGNOSIS OF THYROID DISEASE USING ECHOGRAPHY
Blum, M
1975 ;59(3):301-307, American journal of medicine
— id: 28644, year: 1975, vol: 59, page: 301, stat: Journal Article,

IMPROVED DIAGNOSIS OF NONDELINEATED THYROID NODULES BY OBLIQUE SCINTILLATION SCANNING AND ECHOGRAPHY
BLUM, M; GOLDMAN, AB
1975 ;16(8):713-715, Journal of nuclear medicine
— id: 48799, year: 1975, vol: 16, page: 713, stat: Journal Article,

Hyperthyroidism after iodinated contrast medium
Blum M; Weinberg U; Shenkman L; Hollander CS
1974 Jul 4;291(1):24-25, New England journal of medicine
— id: 29287, year: 1974, vol: 291, page: 24, stat: Journal Article,

THYROID CORK - OBSTRUCTION OF THORACIC INLET DUE TO RETROCLAVICULAR GOITER
BLUM, M; BILLER, BJ; BERGMAN, DA
1974 ;227(2):189-191, JAMA
— id: 39892, year: 1974, vol: 227, page: 189, stat: Journal Article,

HYPERTHYROIDISM AFTER PYELOGRAPHY - REPLY
Blum, M; Weinberg, U; Shenkman, L; Hollande[...], CS
1974 ;291(13):683-683, New England journal of medicine
— id: 28432, year: 1974, vol: 291, page: 683, stat: Journal Article,

Thyroglossal duct carcinoma
Sohn, N; Gumport, S L; Blum, M
1974 Oct;74(11):2004-2005, New York state journal of medicine
— id: 89929, year: 1974, vol: 74, page: 2004, stat: Journal Article,

Measurement of serum thyroxine by the Tetralute procedure: the effect of 131 I and 99m Tc administration
Blum, M; Chandra, R; Drucker, W D
1973 May;14(5):279-282, Journal of nuclear medicine
— id: 167022, year: 1973, vol: 14, page: 279, stat: Journal Article,

Multiple circumscribed pulmonary hematomas masquerading as metastatic carcinoma
Engelman, R M; Boyd, A D; Blum, M; Worth, M H
1973 Mar;15(3):291-294, Annals of thoracic surgery
— id: 107036, year: 1973, vol: 15, page: 291, stat: Journal Article,

Triiodothyronine in diagnosis
Gerhold WM; Shenkmann L; Mitsuma T; Blum M; Hollander CS
1973 Jan;78(1):156-157, Annals of internal medicine
— id: 29298, year: 1973, vol: 78, page: 156, stat: Journal Article,

Iodine and lithium-induced hypothyroidism. Documentation of synergism
Shopsin B; Shenkman L; Blum M; Hollander CS
1973 Nov;55(5):695-699, American journal of medicine
— id: 29291, year: 1973, vol: 55, page: 695, stat: Journal Article,

Myxedema coma
Blum M
1972 Dec;264(6):432-443, American journal of the medical sciences
— id: 63337, year: 1972, vol: 264, page: 432, stat: Journal Article,

Clinical and laboratory observations in cases of triiodothyronine toxicosis confirmed by radioimmunoassay
Hollander CS; Mitsuma T; Nihei N; Shenkman L; Burday SZ; Blum M
1972 Mar 18;1(7751):609-611, Lancet
— id: 29308, year: 1972, vol: 1, page: 609, stat: Journal Article,

Recurrent hyperthyroidism presenting as triiodothyronine toxicosis
Shenkman L; Mitsuma T; Blum M; Hollander CS
1972 Sep;77(3):410-413, Annals of internal medicine
— id: 29302, year: 1972, vol: 77, page: 410, stat: Journal Article,

Environmental contamination with 131-iodine related to the treatment of hyperthyroidism and carcinoma of the thyroid gland
Blum, M.; Chandra, R.; Marshall, C.H.
1971 ;S-18(1):57-59 February, IEEE transactions on nuclear science
— id: 98884, year: 1971, vol: S-18, page: 57, stat: Journal Article,

Artifacts in 99m Tc-sulfur colloid liver scans
Hernberg, J G; Braunstein, P; Chandra, R; Blum, M
1971 Oct;12(10):697-698, Journal of nuclear medicine
— id: 130510, year: 1971, vol: 12, page: 697, stat: Journal Article,

Hypertriiodothyroninaemia as a premonitory manifestation of thyrotoxicosis
Hollander, C S; Shenkman, L; Mitsuma, T; Blum, M; Kastin, A J; Anderson, D G
1971 Oct 2;2(7727):731-733, Lancet
— id: 29313, year: 1971, vol: 2, page: 731, stat: Journal Article,

The metabolism of intravenously injected isotopic cholic acid in Laennec's cirrhosis
Blum, M; Spritz, N
1966 Feb;45(2):187-193, Journal of clinical investigation
— id: 74253, year: 1966, vol: 45, page: 187, stat: Journal Article,

The role of altered bile acid metabolism in the steatorrhea of experimental blind loop
Kim, Y S; Spritz, N; Blum, M; Terz, J; Sherlock, P
1966 Jun;45(6):956-962, Journal of clinical investigation
— id: 74252, year: 1966, vol: 45, page: 956, stat: Journal Article,

Experimental production of blind loop steatorrhea and a study of its pathogenesis
Terz, J J; Kim, Y S; Spritz, N; Blum, M; Sherlock, P
1965 ;16:349-350, Surgical forum
— id: 74258, year: 1965, vol: 16, page: 349, stat: Journal Article,