Miroslav Blumenberg

Biosketch / Results /

Miroslav Blumenberg

Associate Professor, Ronald O. Perelman Department of Dermatology
Associate Professor, Department of Biochemistry and Molecular Pharmacology


Contact Info

Address
455 First Avenue
New York, NY 10016

212/263-5924
Miroslav.Blumenberg@nyumc.org

Research Summary


DNA microarrays allow us to follow global cellular responses to various agents. Using UV light as a paradigmatic damaging agent, we determined that cells make following responses: 1. They change signal transduction and transcription regulators, basically stop what they have been doing and respond to UV. 2. Produce cytokines and chemokine to alert the surrounding tissue to the damage. 3. Produce more energy by increasing mitochondrial proteins and suppressing proteins that use energy. 4. Increase the cornified layer that protects the skin. These responses protect not only the cells, but also the underlying tissues of the organism.
In another study, we described the antiviral effects of Interferon-gamma in skin. Specifically, we found that IFNg suppresses cell cycle and DNA replication ? the cell that does not replicate its own DNA will not replicate the viral either; IFNg boosts tight junction proteins, impeding para-cellular viral entry into the organism, and suppresses epidermal differentiation, which inhibits proliferation of papilloma viruses.
We are extending our studies to other agents that affect skin biology, such as proinflammatory cytokines, DNA damaging agents etc. Recently, we have started a program focused on epidermal stem cells and differentiation. Our goal is to describe the global molecular responses of skin to its environment.

Research Interests

Molecular Biology and Genetics of Human Keratin Genes.
Transcriptional profiling of skin cells using DNA microarrays.
Effects of UV light on skin.
Signal transduction in skin during inflammatory and proliferative processes.
Epidermal stem cells and differentiation.



In vivo mechanisms by which a bioengineered living cell construct stimulates healing of chronic ulcers: Activation, inflammation and remodeling
Stone, RC; Stojadinovic, O; Rosa, AM; Sawaya, A; Ramirez, H; Badiavas, EV; Blumenberg, M; Tomic-Canic, M. In vivo mechanisms by which a bioengineered living cell construct stimulates healing of chronic ulcers: Activation, inflammation and remodeling [Meeting Abstract]. Journal of investigative dermatology. 2016 MAY;136(5):S133-S133 (2216152)

TREATMENT OF CHRONIC VENOUS LEG ULCERS WITH A BIOENGINEERED LIVING CELL CONSTRUCT INDUCES METALLOTHIONEINS AND MMP8 TO RESOLVE MATRIX FIBROSIS AND REACTIVATES A HEALTHY REMODELING RESPONSE
Stone, RC; Stojadinovic, O; Sawaya, AP; Rosa, AM; Badiavas, E; Blumenberg, M; Tomic-Canic, M. TREATMENT OF CHRONIC VENOUS LEG ULCERS WITH A BIOENGINEERED LIVING CELL CONSTRUCT INDUCES METALLOTHIONEINS AND MMP8 TO RESOLVE MATRIX FIBROSIS AND REACTIVATES A HEALTHY REMODELING RESPONSE [Meeting Abstract]. Wound repair & regeneration. 2016 MAR-APR;24(2):A25-A25 (2113652)

Resistin gene polymorphisms are associated with acne and serum lipid levels, providing a potential nexus between lipid metabolism and inflammation
Younis, Sidra; Blumenberg, Miroslav; Javed, Qamar. Resistin gene polymorphisms are associated with acne and serum lipid levels, providing a potential nexus between lipid metabolism and inflammation. Archives of dermatological research. 2016 Feb 8;308(4):229-237 (2044772)

Meta-Analysis of Transcriptional Responses to Mastitis-Causing Escherichia coli
Younis, Sidra; Javed, Qamar; Blumenberg, Miroslav. Meta-Analysis of Transcriptional Responses to Mastitis-Causing Escherichia coli. PLoS one. 2016 Mar 2;11(3):e0148562-e0148562 e0148562 (2006372)

Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block
Clancy, Robert M; Markham, Androo J; Reed, Joanne H; Blumenberg, Miroslav; Halushka, Marc K; Buyon, Jill P. Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block. Journal of autoimmunity. 2015 Oct 1;67:36-45 (1790142)