Biosketch / Results /
Miroslav BlumenbergAssociate Professor, Department of Ronald O. Perelman Department of Dermatology;Associate Professor, Department of Biochemistry and Molecular Pharmacology
455 First Avenue
New York, NY 10016
DNA microarrays allow us to follow global cellular responses to various agents. Using UV light as a paradigmatic damaging agent, we determined that cells make following responses: 1. They change signal transduction and transcription regulators, basically stop what they have been doing and respond to UV. 2. Produce cytokines and chemokine to alert the surrounding tissue to the damage. 3. Produce more energy by increasing mitochondrial proteins and suppressing proteins that use energy. 4. Increase the cornified layer that protects the skin. These responses protect not only the cells, but also the underlying tissues of the organism.
In another study, we described the antiviral effects of Interferon-gamma in skin. Specifically, we found that IFNg suppresses cell cycle and DNA replication ? the cell that does not replicate its own DNA will not replicate the viral either; IFNg boosts tight junction proteins, impeding para-cellular viral entry into the organism, and suppresses epidermal differentiation, which inhibits proliferation of papilloma viruses.
We are extending our studies to other agents that affect skin biology, such as proinflammatory cytokines, DNA damaging agents etc. Recently, we have started a program focused on epidermal stem cells and differentiation. Our goal is to describe the global molecular responses of skin to its environment.
Research InterestsMolecular Biology and Genetics of Human Keratin Genes.
Transcriptional profiling of skin cells using DNA microarrays.
Effects of UV light on skin.
Signal transduction in skin during inflammatory and proliferative processes.
Epidermal stem cells and differentiation.
Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block
Clancy, Robert M; Markham, Androo J; Reed, Joanne H; Blumenberg, Miroslav; Halushka, Marc K; Buyon, Jill P
2015-10-04; 1095-9157,Journal of autoimmunity - id: 1790142, year: 2015 JOURNAL ARTICLE
Keratinocyte p38delta loss inhibits Ras-induced tumor formation, while systemic p38delta loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin
Kiss, Alexi; Koppel, Aaron C; Anders, Joanna; Cataisson, Christophe; Yuspa, Stuart H; Blumenberg, Miroslav; Efimova, Tatiana
2015-03-16; 0899-1987,Molecular carcinogenesis - id: 1494682, year: 2015 JOURNAL ARTICLE
Perez-Perez, Guillermo I; Blumenberg, Miroslav; Alekseyenko, Alexander
2015-07-23; , - id: 1681512, year: 2015
Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function
Rorke, E A; Adhikary, G; Young, C A; Rice, R H; Elias, P M; Crumrine, D; Meyer, J; Blumenberg, M; Eckert, R L
2015-03-02; 2041-4889,Cell death & disease - id: 1474672, year: 2015 Journal Article
Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis
Younis, Sidra; Javed, Qamar; Blumenberg, Miroslav
2015-05-11; 1471-2407,BMC cancer - id: 1569512, year: 2015 JOURNAL ARTICLE