Joshua A. Becker, M.D.

Adjunct Professor;
Department of Radiology (Radiology)
NYU Radiology Associates

Contact Info

Address
530 First Avenue
OB-D121
Schwartz Health Care Center
New York, NY 10016-6481

Email: Joshua.Becker@nyumc.org

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Education

1958-1961 — Temple University Hospital (Radiology), Residency

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Research Summary

The use of radio-opaque contrast media (ROCM) has been an essential portion of imaging since the first primitive agent was introduced in 1929. The current agents are utilized in an ever increasing frequency secondary to the recent introduction of multidetector computerized tomographic units (MDCT). These agents are minimally injurious to most patients. However there are potential hazards. One adverse reaction is nephrotoxicity. This complication is listed as the second most common cause of acute renal failure (ARF) in hospitalized patients.

The current investigation is to evaluate the detection of acute renal failure (ARF) based upon glomerular filtration rate (GFR). The GFR is more appropriate in the evaluation of renal status than serum creatinine determination. This observation is based upon the need to reduce the GFR to <60 ml/min/1.73 m2 (normal 120 ml/min/1.73 m2) before an alteration of the serum creatinine is seen. The change in creatinine level may not be identified until 48 hours after the injection of the ROCM.

The IRB approved investigation is to determine the renal status shortly after the contrast media injection. The evaluation of GFR uses the iodine of the ROCM as the marker. Initially, the base line GFR is established utilizing 15 ml of the ROCM to be used in the diagnostic imaging study. A blood sample is obtained for analysis. The injection of the ROCM, appropriate for the study, is performed. Another blood sample is obtained for analysis. It is appreciated that the impact upon renal function is rapid as is seen in some patients with a persistent nephrogram (prolonged opacification of the renal parenchyma and no opacification of the pelvicalyceal system). The initial investigation is the patient cohort with no predisposing renal function factors (e.g., diabetes mellitus, poor cardiac function, elevated serum creatinine, dehydration, etc.). Following studies will look at the potential protective procedures such as anti-oxidants in the normal and ''at risk'' patients.

Research Keywords

Kidney function

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search#about

Renal safety of gadolinium-based contrast agent for ionizing radiation imaging
Becker, J; Thompson, H
2006 JUL ;240(1):301-302, Radiology
— id: 64635, year: 2006, vol: 240, page: 301, stat: Journal Article,

Urography survives
Becker JA; Pollack HM; McClennan BL
2001 Jan;218(1):299-300, Radiology
— id: 63409, year: 2001, vol: 218, page: 299, stat: Journal Article,

Urography survives
Becker, Joshua A.; Pollack, Howard M.; McClennan, Bruce L.
2001 ;218(1):9010-9015 January,, Radiology
— id: 98793, year: 2001, vol: 218, page: 9010, stat: Journal Article,

The African origin of the common mutation in African American patients with glycogen-storage disease type II
Becker JA; Vlach J; Raben N; Nagaraju K; Adams EM; Hermans MM; Reuser AJ; Brooks SS; Tifft CJ; Hirschhorn R; Huie ML; Nicolino M; Plotz PH
1998 Apr;62(4):991-994, American journal of human genetics
— id: 57102, year: 1998, vol: 62, page: 991, stat: Journal Article,

Progression of childhood linear scleroderma to fatal systemic sclerosis
Mayorquin, F J; McCurley, T L; Levernier, J E; Myers, L K; Becker, J A; Graham, T P; Pincus, T
1994 Oct;21(10):1955-1957, Journal of rheumatology
An 8-year-old girl presented with linear scleroderma, no evidence of systemic disease, and a negative antinuclear antibody (ANA) test. Over the next 12 months, she functioned normally. However, over the subsequent 5 months, she developed dyspnea, progressive pulmonary hypertension, a positive ANA test, and died 17 months after presentation. At autopsy, diffuse pulmonary interstitial fibrosis, small pulmonary arterial fibroplasia, tricuspid and mitral valve subendocardial fibrosis, and distal esophageal fibrosis were seen. Contrary to suggestions in the rheumatology literature, childhood linear scleroderma, even when ANA negative at presentation, may progress to fatal systemic sclerosis
— id: 90316, year: 1994, vol: 21, page: 1955, stat: Journal Article,

URORADIOLOGY UPDATE - EDITORIAL
BECKER, JA; BOSNIAK, MA; BAERT, AL
1992 JUL ;14(1):1-1, Urologic radiology
— id: 51937, year: 1992, vol: 14, page: 1, stat: Journal Article,

GYNECOLOGIC IMAGING
BECKER, JA; BOSNIAK, MA; PALMA, LD
1991 JUN ;13(1):1-1, Urologic radiology
— id: 51592, year: 1991, vol: 13, page: 1, stat: Journal Article,

Retrocaval ureter: sonographic appearance
Schaffer RM; Sunshine AG; Becker JA; Macchia RJ; Shih YH
1985 Apr;4(4):199-201, Journal of ultrasound in medicine
— id: 10145, year: 1985, vol: 4, page: 199, stat: Journal Article,

Hemangiomas of the liver in patients with renal cell carcinoma
Madayag MA; Bosniak MA; Kinkhabwala M; Becker JA
1978 Feb;126(2):391-394, Radiology
Five patients with renal cell carcinoma were noted at angiography to have vascular hepatic lesions which resembled metastatic renal cell carcinoma but which proved to be benign hepatic hemangiomas. The angiographic differentiation between small hemangiomas and metastatic vascular neoplasms of the liver can be difficult; angiographic characteristics may not be definitive. Surgery to remove the renal tumor should not be deferred solely on the basis of vascular hepatic lesions found at angiography
— id: 44217, year: 1978, vol: 126, page: 391, stat: Journal Article,

ANGIOMYOLIPOMA (HAMARTOMA) OF KIDNEY - ANGIOGRAPHIC REVIEW
BECKER, JA; KINKHABW.M; POLLACK, H; BOSNIAK, M
1973 ;14(5):561-568, Acta radiologica. Diagnosis
— id: 39768, year: 1973, vol: 14, page: 561, stat: Journal Article,