Claudio Basilico

Biosketch / Results /

Claudio Basilico, M.D.

Jan T. Vilcek Professor of Molecular Pathogenesis; Chair of the Department of Microbiology
Departments of Microbiology (Microbiology ) and Pathology (Pathology)

Contact Info

Address
522 First Avenue
Floor 10 Room 1001B
Smilow Research Building
New York, NY 10016

212-263-5341
212-263-8714
Claudio.Basilico@med.nyu.edu

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Education

— Dr. Basilico was a research fellow in the division of Biology at the California Institute of technology. In 1966 he became a Research Associate in the Cell Biology Dept at Albert Einstein College of Medicine, PostDoctoral Training

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Research Summary

The major interest of my laboratory is the control of proliferation in normal and cancer cells and the genes and gene-products whose interplay regulates proliferation and differentiation.

To understand how growth factors mediate cell proliferation and differentiation, we are studying the mechanism of action and the regulation of expression of fibroblast growth factors (FGF). FGF represents a large family of growth factors which signal through their interaction with tyrosine kinase receptors (FGFR) which also make-up a gene family. FGF signaling plays a major role in a variety of developmental processes, ranging from gastrulation to bone morphogenesis. Ectopic or excessive FGF expression can lead to oncogenesis. The main projects currently being carried out include:

1) The regulation of expression of the FGF4 gene in vitro and in vivo. FGF4 is an important signaling molecule whose expression is physiologically restricted to embryonic life and plays an essential role in early embryonic development. We have found that its expression depends on distinct enhancer elements, all located in the 3? portion of the gene, that, by interacting with specific transcription factors, direct FGF4 expression in specific embryonic structures, including the blastocyst, myotomes and limb buds. The transcription factors which interact with the blastocyst enhancer have been identified. Sox2 and Oct-3 synergistically activate FGF expression in this tissue by binding to adjacent regions in the enhancer DNA.
2) The physiological role of FGFs, using transgenic mice or gene-ablation techniques. We have generated FGF1, FGF2 and FGF1/FGF2 knockout mice and show that these factors play no essential role in development, but affect the production of specific neurons, the development of hematopoietic precursor cells, and wound-healing. We are in the process of generating mice in which specific FGF4 DNA regulating elements have been deleted, to determine the role of this factor in distinct processes of development (e.g. limb formation).
3) The regulation of bone development by FGF signaling. Unregulated FGF signaling, due to FGFR activating mutations, causes a variety of dominant bone morphogenetic disorders in humans, including several forms of dwarfism and craniosynostosis syndromes, showing that FGF signaling plays an important role in bone development. We are studying the effect of FGF on the two major cell types involved in bone formation, chondrocytes and osteoblasts. A) In chondrocytes, we found that FGF signaling inhibits proliferation and increases apoptosis both in vitro and in vivo. These effects are cell type-specific and require the activation of STAT1, a signal transducing transcription factor which is not normally activated by FGF in other cell types. We are investigating the other downstream effectors of FGF-mediated growth inhibition, how FGFs influence chondrocyte differentiation and the genes whose expression is induced by FGF signaling in chondrocytes and is controlled by STAT1. B) In osteoblasts, FGF signaling has dual effects. Immature osteoblasts respond with stimulation of proliferation, while in differentiating osteoblasts FGFs induce apoptosis. The proapoptotic effect of FGF on osteoblasts can also be demonstrated in vivo in transgenic animals overexpressing FGF2. We are presently investigating the mechanisms by which FGF induces apoptosis in differentiating osteoblasts and the physiological role of this phenomenon in intramembranous ossification, i.e. the formation of the flat bones of the skull. By introducing mutations into the FGFR2 gene, in ES cells, we are also attempting to create mouse models of craniosynostosis, to better study in vivo the alterations of osteoblast proliferation and differentiation that lead to these syndromes.



Research Interests

Signals controlling cell proliferation<br><br> <br>

Research Keywords

cell-cycle, growth factors, oncogenes, signal transduction, bone development<br><br> <br>

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Morphological comparison of the craniofacial phenotypes of mouse models expressing the Apert FGFR2 S252W mutation in neural crest- or mesoderm-derived tissues
Heuze, Yann; Singh, Nandini; Basilico, Claudio; Jabs, Ethylin Wang; Holmes, Greg; Richtsmeier, Joan T
2014 Jun;63:101-109, Bone
— id: 881822, year: 2014, vol: 63, page: 101, stat: Journal Article,

FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells
Murtha, Matthew; Tokcaer-Keskin, Zeynep; Tang, Zuojian; Strino, Francesco; Chen, Xi; Wang, Yatong; Xi, Xiangmei; Basilico, Claudio; Brown, Stuart; Bonneau, Richard; Kluger, Yuval; Dailey, Lisa
2014 May;11(5):559-565, Nature methods
— id: 970072, year: 2014, vol: 11, page: 559, stat: Journal Article,

The role of FGF/FGFR signaling in cranial integration: Implications for primate evolution
Singh, Nandini; Heuze, Yann; Flaherty, Kevin; Basilico, Claudio; Holmes, Gregory; Richtsmeier, Joan T.
2014 MAR;153 58 58(SI):240-240, American journal of physical anthropology
— id: 867522, year: 2014, vol: 153 58 58, page: 240, stat: Journal Article,

Perspectives on cancer stem cells in osteosarcoma
Basu-Roy, Upal; Basilico, Claudio; Mansukhani, Alka
2013 Sep;338(1):158-167, Cancer letters
— id: 512792, year: 2013, vol: 338, page: 158, stat: Journal Article,

The B55alpha Regulatory Subunit of Protein Phosphatase 2A Mediates Fibroblast Growth Factor-Induced p107 Dephosphorylation and Growth Arrest in Chondrocytes
Kolupaeva, Victoria; Daempfling, Lea; Basilico, Claudio
2013 Aug;33(15):2865-2878, Molecular & cellular biology
— id: 425352, year: 2013, vol: 33, page: 2865, stat: Journal Article,

Isolation and analysis of DNA derived from nucleosome-free regions
Murtha, Matthew; Wang, Yatong; Basilico, Claudio; Dailey, Lisa
2013 ;977:35-51, Methods in molecular biology
— id: 271312, year: 2013, vol: 977, page: 35, stat: Journal Article,

SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage
Seo, Eunjeong; Basu-Roy, Upal; Gunaratne, Preethi H; Coarfa, Cristian; Lim, Dae-Sik; Basilico, Claudio; Mansukhani, Alka
2013 Jun;3(6):2075-2087, Cell reports
— id: 958242, year: 2013, vol: 3, page: 2075, stat: Journal Article,

Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
Basu-Roy U; Seo E; Ramanathapuram L; Rapp TB; Perry JA; Orkin SH; Mansukhani A; Basilico C
2012 Sep 19;:2270-2282, Oncogene
— id: 137542, year: 2012, vol: , page: 2270, stat: Journal Article,

Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1
Deckelbaum, Ron A; Holmes, Greg; Zhao, Zhicheng; Tong, Chunxiang; Basilico, Claudio; Loomis, Cynthia A
2012 Apr;139(7):1346-1358, Development
— id: 159856, year: 2012, vol: 139, page: 1346, stat: Journal Article,

Mesodermal expression of Fgfr2(S252W) is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome
Holmes, Greg; Basilico, Claudio
2012 Aug;368(2):283-293, Developmental biology (Orlando)
— id: 174073, year: 2012, vol: 368, page: 283, stat: Journal Article,

Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins
Kolupaeva, Victoria; Basilico, Claudio
2012 Jul;11(13):2557-2566, Cell cycle
— id: 173029, year: 2012, vol: 11, page: 2557, stat: Journal Article,

The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice
Holmes, Greg; Bromage, Timothy G; Basilico, Claudio
2011 Oct;49(4):653-661, Bone
— id: 156318, year: 2011, vol: 49, page: 653, stat: Journal Article,

Regulation of non-classical FGF1 release and FGF-dependent cell transformation by CBF1-mediated notch signaling
Kacer D.; Mcintire C.; Kirov A.; Kany E.; Roth J.; Liaw L.; Small D.; Friesel R.; Basilico C.; Tarantini F.; Verdi J.; Prudovsky I.
2011 ;226(11):3064-3075, Journal of cellular physiology
— id: 137084, year: 2011, vol: 226, page: 3064, stat: Journal Article,

Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage
Seo E; Basu-Roy U; Zavadil J; Basilico C; Mansukhani A
2011 Nov;31(22):4593-4608, Molecular & cellular biology
— id: 137541, year: 2011, vol: 31, page: 4593, stat: Journal Article,

The transcription factor Sox2 is required for osteoblast self-renewal
Basu-Roy, U; Ambrosetti, D; Favaro, R; Nicolis, S K; Mansukhani, A; Basilico, C
2010 Aug;17(8):1345-1353, Cell death & differentiation
— id: 110867, year: 2010, vol: 17, page: 1345, stat: Journal Article,

Sox2 Is Required For The Self-renewal Of The Osteoblast Lineage
Mansukhani, A; Roy, UB; Nicolis, S; Basilico, C
2010 MAR ;46(5):S53-S53, Bone
— id: 109713, year: 2010, vol: 46, page: S53, stat: Journal Article,

FGF inhibits the activity of the cyclin B1/CDK1 kinase to induce a transient G(2) arrest in RCS chondrocytes
Tran, Tri; Kolupaeva, Victoria; Basilico, Claudio
2010 Nov;9(21):4379-4386, Cell cycle
— id: 114189, year: 2010, vol: 9, page: 4379, stat: Journal Article,

Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology
Holmes, Greg; Rothschild, Gerson; Roy, Upal Basu; Deng, Chu-Xia; Mansukhani, Alka; Basilico, Claudio
2009 Apr 15;328(2):273-284, Developmental biology (Orlando)
— id: 99591, year: 2009, vol: 328, page: 273, stat: Journal Article,

Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts
Ambrosetti, Davide; Holmes, Greg; Mansukhani, Alka; Basilico, Claudio
2008 Aug;28(15):4759-4771, Molecular & cellular biology
— id: 80816, year: 2008, vol: 28, page: 4759, stat: Journal Article,

Protein phosphatase PP2A mediates FGF-induced p107 dephosphorylation in chondrocytes
Kolupaeva, V; Laplantine, E; Basilico, C
2008 MAR ;42(5):S56-S56, Bone
— id: 76443, year: 2008, vol: 42, page: S56, stat: Journal Article,

PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF
Kolupaeva, Victoria; Laplantine, Emmanuel; Basilico, Claudio
2008 ;3(10):e3447-e3447, PLoS ONE
— id: 93562, year: 2008, vol: 3, page: e3447, stat: Journal Article,

Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways
Raucci, Angela; Bellosta, Paola; Grassi, Roberta; Basilico, Claudio; Mansukhani, Alka
2008 May;215(2):442-451, Journal of cellular physiology
— id: 74656, year: 2008, vol: 215, page: 442, stat: Journal Article,

Identification of active transcriptional regulatory modules by the functional assay of DNA from nucleosome-free regions
Yaragatti, Mahesh; Basilico, Claudio; Dailey, Lisa
2008 Jun;18(6):930-938, Genome research
— id: 80304, year: 2008, vol: 18, page: 930, stat: Journal Article,

Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes
Priore, Riccardo; Dailey, Lisa; Basilico, Claudio
2006 Jun;207(3):800-808, Journal of cellular physiology
— id: 64470, year: 2006, vol: 207, page: 800, stat: Journal Article,

Introduction to the special FGF issue
Basilico C
2005 Apr;16(2):105-106, Cytokine & growth factor reviews
— id: 55972, year: 2005, vol: 16, page: 105, stat: Journal Article,

A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
Budagian, Vadim; Bulanova, Elena; Orinska, Zane; Thon, Lutz; Mamat, Uwe; Bellosta, Paola; Basilico, Claudio; Adam, Dieter; Paus, Ralf; Bulfone-Paus, Silvia
2005 Dec 21;24(24):4260-4270, EMBO journal
— id: 95115, year: 2005, vol: 24, page: 4260, stat: Journal Article,

Mechanisms underlying differential responses to FGF signaling
Dailey, Lisa; Ambrosetti, Davide; Mansukhani, Alka; Basilico, Claudio
2005 Apr;16(2):233-247, Cytokine & growth factor reviews
— id: 55971, year: 2005, vol: 16, page: 233, stat: Journal Article,

Fibroblast growth factors share binding sites in heparan sulphate
Kreuger, Johan; Jemth, Per; Sanders-Lindberg, Emil; Eliahu, Liat; Ron, Dina; Basilico, Claudio; Salmivirta, Markku; Lindahl, Ulf
2005 Jul 1;389(Pt 1):145-150, Biochemical journal
— id: 95116, year: 2005, vol: 389, page: 145, stat: Journal Article,

Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
Mansukhani, Alka; Ambrosetti, Davide; Holmes, Greg; Cornivelli, Lizbeth; Basilico, Claudio
2005 Mar 28;168(7):1065-1076, Journal of cell biology
— id: 55788, year: 2005, vol: 168, page: 1065, stat: Journal Article,

A conserved enhancer element that drives FGF4 gene expression in the embryonic myotomes is synergistically activated by GATA and bHLH proteins
Iwahori, Akiyo; Fraidenraich, Diego; Basilico, Claudio
2004 Jun 15;270(2):525-537, Developmental biology (Orlando)
— id: 44724, year: 2004, vol: 270, page: 525, stat: Journal Article,

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
Olsen, Shaun K; Ibrahimi, Omar A; Raucci, Angela; Zhang, Fuming; Eliseenkova, Anna V; Yayon, Avner; Basilico, Claudio; Linhardt, Robert J; Schlessinger, Joseph; Mohammadi, Moosa
2004 Jan 27;101(4):935-940, Proceedings of the National Academy of Sciences of the United States of America
— id: 42613, year: 2004, vol: 101, page: 935, stat: Journal Article,

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
Raucci, Angela; Laplantine, Emmanuel; Mansukhani, Alka; Basilico, Claudio
2004 Jan 16;279(3):1747-1756, Journal of biological chemistry
— id: 48184, year: 2004, vol: 279, page: 1747, stat: Journal Article,

p21(WAF1/CIP1) acts as a brake in osteoblast differentiation
Bellosta, Paola; Masramon, Laia; Mansukhani, Alka; Basilico, Claudio
2003 May;18(5):818-826, Journal of bone & mineral research
— id: 34520, year: 2003, vol: 18, page: 818, stat: Journal Article,

FGF signaling initiates multiple pathways to induce growth arrest and promote hypertrophic differentiation of chondrocytes
Dailey, L; LaPlantine, E; Priore, R; Basilico, C
2003 MAY ;32(5):S144-S144, Bone
— id: 38552, year: 2003, vol: 32, page: S144, stat: Journal Article,

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation
Dailey, Lisa; Laplantine, Emmanuel; Priore, Riccardo; Basilico, Claudio
2003 Jun 23;161(6):1053-1066, Journal of cell biology
— id: 39184, year: 2003, vol: 161, page: 1053, stat: Journal Article,

Fibroblast growth factor (FGF) signaling in immature and mature osteoblasts
Mansukhani, A; Cornivelli, L; Basilico, C
2003 MAY ;32(5):S144-S144, Bone
— id: 38551, year: 2003, vol: 32, page: S144, stat: Journal Article,

Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer
Polnaszek, Nathaniel; Kwabi-Addo, Bernard; Peterson, Leif E; Ozen, Mustafa; Greenberg, Norman M; Ortega, Sagrario; Basilico, Claudio; Ittmann, Michael
2003 Sep 15;63(18):5754-5760, Cancer research
— id: 44725, year: 2003, vol: 63, page: 5754, stat: Journal Article,

Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
Yu, Chundong; Wang, Fen; Jin, Chengliu; Huang, Xinqiang; Miller, David L; Basilico, Claudio; McKeehan, Wallace L
2003 Oct;163(4):1653-1662, American journal of pathology
— id: 44726, year: 2003, vol: 163, page: 1653, stat: Journal Article,

Fibroblast growth factor 2 is necessary for the growth of glutamate projection neurons in the anterior neocortex
Korada, Sailaja; Zheng, Wei; Basilico, Claudio; Schwartz, Michael L; Vaccarino, Flora M
2002 Feb 1;22(3):863-875, Journal of neuroscience
— id: 34523, year: 2002, vol: 22, page: 863, stat: Journal Article,

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest
Laplantine, Emmanuel; Rossi, Ferdinand; Sahni, Malika; Basilico, Claudio; Cobrinik, David
2002 Aug 19;158(4):741-750, Journal of cell biology
— id: 34521, year: 2002, vol: 158, page: 741, stat: Journal Article,

Fibroblast growth factor induces divergent signals in immature versus mature osteoblasts
Mansukhani, A; Basilico, C
2002 Mar;30(3):C27-, Bone
— id: 27515, year: 2002, vol: 30, page: C27, stat: Journal Article,

Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells
Pintucci, Giuseppe; Moscatelli, David; Saponara, Fiorella; Biernacki, Peter R; Baumann, F Gregory; Bizekis, Costas; Galloway, Aubrey C; Basilico, Claudio; Mignatti, Paolo
2002 Apr;16(6):598-600, FASEB journal
— id: 34522, year: 2002, vol: 16, page: 598, stat: Journal Article,

Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis
Bellosta P; Iwahori A; Plotnikov AN; Eliseenkova AV; Basilico C; Mohammadi M
2001 Sep;21(17):5946-5957, Molecular & cellular biology
— id: 26713, year: 2001, vol: 21, page: 5946, stat: Journal Article,

Polio vaccine samples not linked to AIDS
Blancou P; Vartanian JP; Christopherson C; Chenciner N; Basilico C; Kwok S; Wain-Hobson S
2001 Apr 26;410(6832):1045-1046, Nature
— id: 34526, year: 2001, vol: 410, page: 1045, stat: Journal Article,

Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes
Dailey L; Basilico C
2001 Mar;186(3):315-328, Journal of cellular physiology
— id: 26799, year: 2001, vol: 186, page: 315, stat: Journal Article,

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
Sahni M; Raz R; Coffin JD; Levy D; Basilico C
2001 Jun;128(11):2119-2129, Development
— id: 26721, year: 2001, vol: 128, page: 2119, stat: Journal Article,

Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria
Torre D; Giola M; Speranza F; Matteelli A; Basilico C; Biondi G
2001 Apr-Jun;12(2):361-364, European cytokine network
— id: 34525, year: 2001, vol: 12, page: 361, stat: Journal Article,

Evolution of coinfection with human immunodeficiency virus and hepatitis C virus in patients treated with highly active antiretroviral therapy
Torre D; Tambini R; Cadario F; Barbarini G; Moroni M; Basilico C
2001 Nov 1;33(9):1579-1585, Clinical infectious diseases
— id: 34524, year: 2001, vol: 33, page: 1579, stat: Journal Article,

Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer
Ambrosetti DC; Scholer HR; Dailey L; Basilico C
2000 Jul 28;275(30):23387-23397, Journal of biological chemistry
— id: 11713, year: 2000, vol: 275, page: 23387, stat: Journal Article,

Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog [In Process Citation]
Fraidenraich D; Iwahori A; Rudnicki M; Basilico C
2000 Sep 15;225(2):392-406, Developmental biology (Orlando)
— id: 11501, year: 2000, vol: 225, page: 392, stat: Journal Article,

Different point mutations in the met oncogene elicit distinct biological properties
Giordano S; Maffe A; Williams TA; Artigiani S; Gual P; Bardelli A; Basilico C; Michieli P; Comoglio PM
2000 Feb;14(2):399-406, FASEB journal
— id: 14406, year: 2000, vol: 14, page: 399, stat: Journal Article,

Distal most limb structures develop despite absence of Shh signaling in mouse
Kraus, P; Fraidenraich, D; Basilico, C; Loomis, CA
2000 JUN 1 ;222(1):267-267, Developmental biology (Orlando)
— id: 54562, year: 2000, vol: 222, page: 267, stat: Journal Article,

Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts
Mansukhani A; Bellosta P; Sahni M; Basilico C
2000 Jun 12;149(6):1297-1308, Journal of cell biology
— id: 11658, year: 2000, vol: 149, page: 1297, stat: Journal Article,

Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice [published erratum appears in Mol Cell Biol 2000 May;20(10):3752]
Miller DL; Ortega S; Bashayan O; Basch R; Basilico C
2000 Mar;20(6):2260-2268, Molecular & cellular biology
— id: 11824, year: 2000, vol: 20, page: 2260, stat: Journal Article,

Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice (vol 20, pg 2260, 2000)
Miller, DL; Ortega, S; Bashayan, O; Basch, R; Basilico, C
2000 MAY ;20(10):3752-3752, Molecular & cellular biology
— id: 54696, year: 2000, vol: 20, page: 3752, stat: Journal Article,

Circulating levels of IL-18 in adult and paediatric patients with HIV-1 infection
Torre D; Speranza F; Martegani R; Pugliese A; Castelli F; Basilico C; Biondi G
2000 Sep 29;14(14):2211-2212, AIDS
— id: 14405, year: 2000, vol: 14, page: 2211, stat: Journal Article,

Levels of the bcl-2 protein, fibronectin and alpha(5)beta(1) fibronectin receptor in HIV-1-infected patients with Kaposi's sarcoma
Torre D; Zeroli C; Martegani R; Pugliese A; Basilico C; Speranza F
2000 Dec;2(15):1831-1833, Microbes & infection
— id: 34527, year: 2000, vol: 2, page: 1831, stat: Journal Article,

Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt
Allen MP; Zeng C; Schneider K; Xiong X; Meintzer MK; Bellosta P; Basilico C; Varnum B; Heidenreich KA; Wierman ME
1999 Feb;13(2):191-201, Molecular endocrinology
— id: 14408, year: 1999, vol: 13, page: 191, stat: Journal Article,

Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists
Michieli P; Basilico C; Pennacchietti S; Maffe A; Tamagnone L; Giordano S; Bardelli A; Comoglio PM
1999 Sep 16;18(37):5221-5231, Oncogene
— id: 14407, year: 1999, vol: 18, page: 5221, stat: Journal Article,

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
Sahni M; Ambrosetti DC; Mansukhani A; Gertner R; Levy D; Basilico C
1999 Jun 1;13(11):1361-1366, Genes & development
— id: 12005, year: 1999, vol: 13, page: 1361, stat: Journal Article,

Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
Bardelli A; Longati P; Gramaglia D; Basilico C; Tamagnone L; Giordano S; Ballinari D; Michieli P; Comoglio PM
1998 Nov 24;95(24):14379-14383, Proceedings of the National Academy of Sciences of the United States of America
— id: 14409, year: 1998, vol: 95, page: 14379, stat: Journal Article,

Distinct regulatory elements govern Fgf4 gene expression in the mouse blastocyst, myotomes, and developing limb
Fraidenraich D; Lang R; Basilico C
1998 Dec 1;204(1):197-209, Developmental biology (Orlando)
— id: 7333, year: 1998, vol: 204, page: 197, stat: Journal Article,

FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells
Johnson MR; Valentine C; Basilico C; Mansukhani A
1998 May;16(20):2647-2656, Oncogene
— id: 8389, year: 1998, vol: 16, page: 2647, stat: Journal Article,

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
Ortega S; Ittmann M; Tsang SH; Ehrlich M; Basilico C
1998 May 12;95(10):5672-5677, Proceedings of the National Academy of Sciences of the United States of America
— id: 56758, year: 1998, vol: 95, page: 5672, stat: Journal Article,

Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization [see comments]
Ozaki H; Okamoto N; Ortega S; Chang M; Ozaki K; Sadda S; Vinores MA; Derevjanik N; Zack DJ; Basilico C; Campochiaro PA
1998 Sep;153(3):757-765, American journal of pathology
— id: 7727, year: 1998, vol: 153, page: 757, stat: Journal Article,

Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model
Tobe T; Ortega S; Luna JD; Ozaki H; Okamoto N; Derevjanik NL; Vinores SA; Basilico C; Campochiaro PA
1998 Nov;153(5):1641-1646, American journal of pathology
— id: 7826, year: 1998, vol: 153, page: 1641, stat: Journal Article,

Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites
Ambrosetti DC; Basilico C; Dailey L
1997 Nov;17(11):6321-6329, Molecular & cellular biology
— id: 12266, year: 1997, vol: 17, page: 6321, stat: Journal Article,

Regulatory mechanisms governing FGF-4 gene expression during mouse development
Basilico C; Ambrosetti D; Fraidenraich D; Dailey L
1997 Nov;173(2):227-232, Journal of cellular physiology
— id: 12227, year: 1997, vol: 173, page: 227, stat: Journal Article,

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation
Bellosta P; Zhang Q; Goff SP; Basilico C
1997 Nov 13;15(20):2387-2397, Oncogene
— id: 12211, year: 1997, vol: 15, page: 2387, stat: Journal Article,

FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression
Guthridge MA; Bellosta P; Tavoloni N; Basilico C
1997 Sep;17(9):5485-5498, Molecular & cellular biology
— id: 7161, year: 1997, vol: 17, page: 5485, stat: Journal Article,

Activation of FGF receptors by mutations in the transmembrane domain
Li Y; Mangasarian K; Mansukhani A; Basilico C
1997 Mar 27;14(12):1397-1406, Oncogene
— id: 8208, year: 1997, vol: 14, page: 1397, stat: Journal Article,

Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2
Mangasarian K; Li Y; Mansukhani A; Basilico C
1997 Jul;172(1):117-125, Journal of cellular physiology
— id: 8385, year: 1997, vol: 172, page: 117, stat: Journal Article,

Basic fibroblast growth factor is not necessary for the development of retinal neovascularization
Ozaki, H; Ortega, S; Basilico, C; Campochiaro, PA
1997 MAR 15 ;38(4):2848-2848, Investigative ophthalmology & visual science. IOVS
— id: 53236, year: 1997, vol: 38, page: 2848, stat: Journal Article,

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation
Schwenger P; Bellosta P; Vietor I; Basilico C; Skolnik EY; Vilcek J
1997 Apr 1;94(7):2869-2873, Proceedings of the National Academy of Sciences of the United States of America
— id: 57523, year: 1997, vol: 94, page: 2869, stat: Journal Article,

Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor
Campochiaro PA; Chang M; Ohsato M; Vinores SA; Nie Z; Hjelmeland L; Mansukhani A; Basilico C; Zack DJ
1996 Mar 1;16(5):1679-1688, Journal of neuroscience
— id: 14410, year: 1996, vol: 16, page: 1679, stat: Journal Article,

Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo
Costa M; Bellosta P; Basilico C
1996 Sep;168(3):737-744, Journal of cellular physiology
— id: 12555, year: 1996, vol: 168, page: 737, stat: Journal Article,

Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts
Guthridge MA; Seldin M; Basilico C
1996 Mar 21;12(6):1267-1278, Oncogene
— id: 7001, year: 1996, vol: 12, page: 1267, stat: Journal Article,

Effects of fibroblast growth factor-4 (k-FGF) on long-term cultures of human bone marrow cells
Quito FL; Beh J; Bashayan O; Basilico C; Basch RS
1996 Feb 15;87(4):1282-1291, Blood
— id: 7034, year: 1996, vol: 87, page: 1282, stat: Journal Article,

Fibroblast growth factor receptors 1 and 2 are differentially regulated in murine embryonal carcinoma cells and in response to fibroblast growth factor-4
Ali J; Mansukhani A; Basilico C
1995 Nov;165(2):438-448, Journal of cellular physiology
— id: 12716, year: 1995, vol: 165, page: 438, stat: Journal Article,

The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding
Bellosta P; Costa M; Lin DA; Basilico C
1995 Feb;15(2):614-625, Molecular & cellular biology
— id: 8207, year: 1995, vol: 15, page: 614, stat: Journal Article,

THE ANTICOAGULATION FACTOR PROTEIN-S AND ITS RELATIVE, GAS6, ARE LIGANDS FOR THE TYRO 3/AXL FAMILY OF RECEPTOR TYROSINE KINASES
STITT, TN; CONN, G; GORE, M; LAI, C; BRUNO, J; RADZIEJEWSKI, C; MATTSSON, K; FISHER, J; GIES, DR; JONES, PF; MASIAKOWSKI, P; RYAN, TE; TOBKES, NJ; CHEN, DH; DISTEFANO, PS; LONG, GL; BASILICO, C; GOLDFARB, MP; LEMKE, G; GLASS, DJ; YANCOPOULOS, GD
1995 FEB 24 ;80(4):661-670, Cell
— id: 87416, year: 1995, vol: 80, page: 661, stat: Journal Article,

Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
Yuan H; Corbi N; Basilico C; Dailey L
1995 Nov 1;9(21):2635-2645, Genes & development
— id: 56811, year: 1995, vol: 9, page: 2635, stat: Journal Article,

Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer
Dailey L; Yuan H; Basilico C
1994 Dec;14(12):7758-7769, Molecular & cellular biology
— id: 14411, year: 1994, vol: 14, page: 7758, stat: Journal Article,

EXPRESSION OF INT-2 ONCOGENE IN KAPOSIS-SARCOMA LESIONS
HUANG, YQ; LI, JJ; MOSCATELLI, D; BASILICO, C; NICOLAIDES, A; ZHANG, WG; POIESZ, BJ; FRIEDMANKIEN, AE
1994 AUG ;10(3-4):S54-S54, AIDS research & human retroviruses
— id: 52370, year: 1994, vol: 10, page: S54, stat: Journal Article,

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors
Li Y; Basilico C; Mansukhani A
1994 Nov;14(11):7660-7669, Molecular & cellular biology
— id: 6681, year: 1994, vol: 14, page: 7660, stat: Journal Article,

EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN AIDS-ASSOCIATED KAPOSIS-SARCOMA TISSUE AND DERIVED CELLS
LI, JJ; HUANG, YQ; MOSCATELLI, D; BASILICO, C; NICOLAIDES, A; ZHANG, WG; POIESZ, BJ; FRIEDMANKIEN, AE
1994 AUG ;10(3-4):S52-S52, AIDS research & human retroviruses
— id: 52369, year: 1994, vol: 10, page: S52, stat: Journal Article,

Expression and function of FGF-4 in peri-implantation development in mouse embryos
Rappolee DA; Basilico C; Patel Y; Werb Z
1994 Aug;120(8):2259-2269, Development
— id: 14412, year: 1994, vol: 120, page: 2259, stat: Journal Article,

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding
Roghani M; Mansukhani A; Dell'Era P; Bellosta P; Basilico C; Rifkin DB; Moscatelli D
1994 Feb 11;269(6):3976-3984, Journal of biological chemistry
— id: 6499, year: 1994, vol: 269, page: 3976, stat: Journal Article,

Cleavage of K-FGF produces a truncated molecule with increased biological activity and receptor binding affinity
Bellosta P; Talarico D; Rogers D; Basilico C
1993 May;121(3):705-713, Journal of cell biology
— id: 8206, year: 1993, vol: 121, page: 705, stat: Journal Article,

Involvement of the conserved acidic amino acid domain of FGF receptor 1 in ligand-receptor interaction
Chaudhuri MM; Moscatelli D; Basilico C
1993 Nov;157(2):209-216, Journal of cellular physiology
— id: 6332, year: 1993, vol: 157, page: 209, stat: Journal Article,

Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression
Guerrini L; Gong SS; Mangasarian K; Basilico C
1993 Jun;13(6):3202-3212, Molecular & cellular biology
— id: 13153, year: 1993, vol: 13, page: 3202, stat: Journal Article,

Expression of int-2 oncogene in Kaposi's sarcoma lesions
Huang YQ; Li JJ; Moscatelli D; Basilico C; Nicolaides A; Zhang WG; Poiesz BJ; Friedman-Kien AE
1993 Mar;91(3):1191-1197, Journal of clinical investigation
— id: 13228, year: 1993, vol: 91, page: 1191, stat: Journal Article,

The gene complementing a temperature-sensitive cell cycle mutant of BHK cells is the human homologue of the yeast RPC53 gene, which encodes a subunit of RNA polymerase C (III)
Ittmann M; Ali J; Greco A; Basilico C
1993 Jun;4(6):503-511, Cell growth & differentiation
— id: 13147, year: 1993, vol: 4, page: 503, stat: Journal Article,

A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas
Talarico D; Ittmann MM; Bronson R; Basilico C
1993 Apr;13(4):1998-2010, Molecular & cellular biology
— id: 13207, year: 1993, vol: 13, page: 1998, stat: Journal Article,

FIBROBLAST GROWTH-FACTOR RECEPTOR-4 SHOWS NOVEL FEATURES IN GENOMIC STRUCTURE, LIGAND-BINDING AND SIGNAL TRANSDUCTION
VAINIKKA, S; PARTANEN, J; BELLOSTA, P; COULIER, F; BASILICO, C; JAYE, M; ALITALO, K
1993 JAN 9 ;53(5):243-243, Journal of cellular biochemistry
— id: 54365, year: 1993, vol: 53, page: 243, stat: Journal Article,

The FGF family of growth factors and oncogenes
Basilico C; Moscatelli D
1992 ;59:115-165, Advances in cancer research
— id: 13785, year: 1992, vol: 59, page: 115, stat: Journal Article,

Angiogenic activity of the K-fgf/hst oncogene in neural transplants
Brustle O; Aguzzi A; Talarico D; Basilico C; Kleihues P; Wiestler OD
1992 Jun;7(6):1177-1183, Oncogene
— id: 14414, year: 1992, vol: 7, page: 1177, stat: Journal Article,

Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin
Mansukhani A; Dell'Era P; Moscatelli D; Kornbluth S; Hanafusa H; Basilico C
1992 Apr 15;89(8):3305-3309, Proceedings of the National Academy of Sciences of the United States of America
— id: 13631, year: 1992, vol: 89, page: 3305, stat: Journal Article,

Collagen-induced release of interleukin 1 from human blood mononuclear cells. Potentiation by fibronectin binding to the alpha 5 beta 1 integrin
Pacifici R; Basilico C; Roman J; Zutter MM; Santoro SA; McCracken R
1992 Jan;89(1):61-67, Journal of clinical investigation
— id: 14415, year: 1992, vol: 89, page: 61, stat: Journal Article,

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction [published erratum appears in EMBO J 1993 Feb;12(2):810]
Vainikka S; Partanen J; Bellosta P; Coulier F; Birnbaum D; Basilico C; Jaye M; Alitalo K
1992 Dec;11(12):4273-4280, EMBO journal
— id: 14413, year: 1992, vol: 11, page: 4273, stat: Journal Article,

Regulation of asparagine synthetase gene expression by amino acid starvation
Gong SS; Guerrini L; Basilico C
1991 Dec;11(12):6059-6066, Molecular & cellular biology
— id: 13834, year: 1991, vol: 11, page: 6059, stat: Journal Article,

Response
Kaner RJ; Baird A; Florklewicz RZ; Mansukhani A; Basilico C; Hajjar DP
1991 Jul 12;253(5016):209-210, Science
— id: 95117, year: 1991, vol: 253, page: 209, stat: Journal Article,

A putative receptor tyrosine kinase with unique structural topology
Rescigno J; Mansukhani A; Basilico C
1991 Oct;6(10):1909-1913, Oncogene
— id: 13882, year: 1991, vol: 6, page: 1909, stat: Journal Article,

The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway
Talarico D; Basilico C
1991 Feb;11(2):1138-1145, Molecular & cellular biology
— id: 14144, year: 1991, vol: 11, page: 1138, stat: Journal Article,

Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene
Watanabe M; Furuno N; Goebl M; Go M; Miyauchi K; Sekiguchi T; Basilico C; Nishimito T
1991 Sep;100(Pt 1):35-43, Journal of cell science
— id: 14416, year: 1991, vol: 100, page: 35, stat: Journal Article,

Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells
Curatola AM; Basilico C
1990 Jun;10(6):2475-2484, Molecular & cellular biology
— id: 14419, year: 1990, vol: 10, page: 2475, stat: Journal Article,

Antihistaminic/antiallergic activity of 2-dialkylaminoalkylthio(oxy)-1-substituted benzimidazoles: evaluation "in vitro" and "in vivo"
Dini S; Caselli GF; Basilico C; Lavezzo A; Giani R
1990 Apr;30(1-2):174-177, Agents & actions
— id: 14422, year: 1990, vol: 30, page: 174, stat: Journal Article,

A mammalian temperature-sensitive mutation affecting G1 progression results from a single amino acid substitution in asparagine synthetase
Gong SS; Basilico C
1990 Jun 25;18(12):3509-3513, Nucleic acids research
— id: 14417, year: 1990, vol: 18, page: 3509, stat: Journal Article,

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis
Hebert JM; Basilico C; Goldfarb M; Haub O; Martin GR
1990 Apr;138(2):454-463, Developmental biology (Orlando)
— id: 14421, year: 1990, vol: 138, page: 454, stat: Journal Article,

Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1 [see comments]
Kaner RJ; Baird A; Mansukhani A; Basilico C; Summers BD; Florkiewicz RZ; Hajjar DP
1990 Jun 15;248(4961):1410-1413, Science
— id: 14418, year: 1990, vol: 248, page: 1410, stat: Journal Article,

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF
Mansukhani A; Moscatelli D; Talarico D; Levytska V; Basilico C
1990 Jun;87(11):4378-4382, Proceedings of the National Academy of Sciences of the United States of America
— id: 14420, year: 1990, vol: 87, page: 4378, stat: Journal Article,

Protection of mice against tumor growth by immunization with an oncogene-encoded growth factor
Talarico D; Ittmann M; Balsari A; Delli-Bovi P; Basch RS; Basilico C
1990 Jun;87(11):4222-4225, Proceedings of the National Academy of Sciences of the United States of America
— id: 14365, year: 1990, vol: 87, page: 4222, stat: Journal Article,

Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor
Wellstein A; Lupu R; Zugmaier G; Flamm SL; Cheville AL; Delli Bovi P; Basilico C; Lippman ME; Kern FG
1990 Feb;1(2):63-71, Cell growth & differentiation
— id: 14423, year: 1990, vol: 1, page: 63, stat: Journal Article,

EXPRESSION OF FIBROBLAST GROWTH-FACTOR RECEPTOR GENE IN HUMAN-MELANOMA CELLS
Zouzias, DC; Mansukhani, A; Basilico, C
1990 Apr;38(2):A663-A663, Clinical research
— id: 32082, year: 1990, vol: 38, page: A663, stat: Journal Article,

EXPRESSION OF FIBROBLAST GROWTH-FACTOR RECEPTOR GENE IN HUMAN-MELANOMA CELLS
Zouzias, DC; Mansukhani, A; Basilico, C
1990 Apr;94(4):594-594, Journal of investigative dermatology
— id: 32101, year: 1990, vol: 94, page: 594, stat: Journal Article,

Expression and activation of the K-fgf oncogene
Basilico C; Newman KM; Curatola AM; Talarico D; Mansukhani A; Velcich A; Delli-Bovi P
1989 ;567:95-103, Annals of the New York Academy of Sciences
— id: 10786, year: 1989, vol: 567, page: 95, stat: Journal Article,

Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase
Greco A; Gong SS; Ittmann M; Basilico C
1989 Jun;9(6):2350-2359, Molecular & cellular biology
— id: 10604, year: 1989, vol: 9, page: 2350, stat: Journal Article,

Chromosomal localization of human genes required for G1 progression in mammalian cells
Greco A; Ittmann M; Barletta C; Basilico C; Croce CM; Cannizzaro LA; Huebner K
1989 Apr;4(3):240-245, Genomics
— id: 10677, year: 1989, vol: 4, page: 240, stat: Journal Article,

Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf
Quarto N; Talarico D; Sommer A; Florkiewicz R; Basilico C; Rifkin DB
1989 ;5(2):101-110, Oncogene research
— id: 10813, year: 1989, vol: 5, page: 101, stat: Journal Article,

Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells
Velcich A; Delli-Bovi P; Mansukhani A; Ziff EB; Basilico C
1989 ;5(1):31-37, Oncogene research
— id: 10762, year: 1989, vol: 5, page: 31, stat: Journal Article,

Cell cycle control in eukaryotes
Beach, David; Basilico, Claudio; Newport, John
Cold Spring Harbor NY : Cold Spring Harbor Laboratory, 1988,
— id: 2090, year: 1988, vol: , page: , stat: ,

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential
Delli-Bovi P; Curatola AM; Newman KM; Sato Y; Moscatelli D; Hewick RM; Rifkin DB; Basilico C
1988 Jul;8(7):2933-2941, Molecular & cellular biology
— id: 11053, year: 1988, vol: 8, page: 2933, stat: Journal Article,

The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2
Huebner K; Ferrari AC; Delli Bovi P; Croce CM; Basilico C
1988 ;3(3):263-270, Oncogene research
— id: 14424, year: 1988, vol: 3, page: 263, stat: Journal Article,

Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma DNA
Delli Bovi P; Basilico C
1987 Aug;84(16):5660-5664, Proceedings of the National Academy of Sciences of the United States of America
— id: 14427, year: 1987, vol: 84, page: 5660, stat: Journal Article,

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family
Delli Bovi P; Curatola AM; Kern FG; Greco A; Ittmann M; Basilico C
1987 Aug 28;50(5):729-737, Cell
— id: 14426, year: 1987, vol: 50, page: 729, stat: Journal Article,

Molecular cloning of a gene that is necessary for G1 progression in mammalian cells
Greco A; Ittmann M; Basilico C
1987 Mar;84(6):1565-1569, Proceedings of the National Academy of Sciences of the United States of America
— id: 14429, year: 1987, vol: 84, page: 1565, stat: Journal Article,

Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells
Ittmann M; Greco A; Basilico C
1987 Oct;7(10):3386-3393, Molecular & cellular biology
— id: 11347, year: 1987, vol: 7, page: 3386, stat: Journal Article,

A reiterated leader sequence is present in polyomavirus late transcripts produced by a transformed rat cell line
Kern FG; Bovi PD; Basilico C
1987 Dec;61(12):4055-4059, Journal of virology
— id: 11315, year: 1987, vol: 61, page: 4055, stat: Journal Article,

The transcription of B2 repeated sequences is regulated during the transition from quiescent to proliferative state in cultured rodent cells
Lania L; Pannuti A; La Mantia G; Basilico C
1987 Jul 27;219(2):400-404, FEBS letters
— id: 14428, year: 1987, vol: 219, page: 400, stat: Journal Article,

Amplification and expression of foreign genes in cells producing polyoma virus large T-antigen
Pellegrini S; Basilico C
1987 Jun;1(1):23-41, Oncogene research
— id: 11395, year: 1987, vol: 1, page: 23, stat: Journal Article,

DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro
Prives C; Murakami Y; Kern FG; Folk W; Basilico C; Hurwitz J
1987 Oct;7(10):3694-3704, Molecular & cellular biology
— id: 14425, year: 1987, vol: 7, page: 3694, stat: Journal Article,

A subclass of polyomavirus middle tumor antigen binds to DNA cellulose
Bolen JB; Cary K; Scheller A; Basilico C; Israel MA; Prives C
1986 Apr;58(1):157-164, Journal of virology
— id: 14434, year: 1986, vol: 58, page: 157, stat: Journal Article,

Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma
Delli Bovi P; Donti E; Knowles DM 2d; Friedman-Kien A; Luciw PA; Dina D; Dalla-Favera R; Basilico C
1986 Dec;46(12 Pt 1):6333-6338, Cancer research
— id: 14431, year: 1986, vol: 46, page: 6333, stat: Journal Article,

ISOLATION AND STUDY OF THE HUMAN-GENE WHICH COMPLEMENTS THE MUTATION IN A TEMPERATURE-SENSITIVE MUTANT OF THE BHK CELL-LINE
GRECO, A; ITTMANN, M; BASILICO, C
1986 NOV ;103(5):A150-A150, Journal of cell biology
— id: 41319, year: 1986, vol: 103, page: A150, stat: Journal Article,

An inducible eukaryotic host-vector expression system: amplification of genes under the control of the polyoma late promoter in a cell line producing a thermolabile large T antigen
Kern FG; Basilico C
1986 ;43(3):237-245, Gene
— id: 14437, year: 1986, vol: 43, page: 237, stat: Journal Article,

Regulation of polyomavirus late promoter activity by viral early proteins
Kern FG; Pellegrini S; Cowie A; Basilico C
1986 Oct;60(1):275-285, Journal of virology
— id: 14433, year: 1986, vol: 60, page: 275, stat: Journal Article,

[Biological action of contaminating fungi of food for chickens]
Lura MC; Basilico C
1986 ;37(4):437-440, Acta cientifica venezolana
— id: 14436, year: 1986, vol: 37, page: 437, stat: Journal Article,

Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis
Pelicci PG; Knowles DM 2d; Arlin ZA; Wieczorek R; Luciw P; Dina D; Basilico C; Dalla-Favera R
1986 Dec 1;164(6):2049-2060, Journal of experimental medicine
— id: 14430, year: 1986, vol: 164, page: 2049, stat: Journal Article,

Rat fibroblasts expressing high levels of human c-myc transcripts are anchorage-independent and tumorigenic
Pellegrini S; Basilico C
1986 Jan;126(1):107-114, Journal of cellular physiology
— id: 14435, year: 1986, vol: 126, page: 107, stat: Journal Article,

Adenovirus E1a proteins repress expression from polyomavirus early and late promoters
Velcich A; Kern FG; Basilico C; Ziff EB
1986 Nov;6(11):4019-4025, Molecular & cellular biology
— id: 14432, year: 1986, vol: 6, page: 4019, stat: Journal Article,

Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expression
Dailey L; Basilico C
1985 Jun;54(3):739-749, Journal of virology
— id: 14439, year: 1985, vol: 54, page: 739, stat: Journal Article,

Transcription from the polyoma late promoter in cells stably transformed by chimeric plasmids
Kern FG; Basilico C
1985 Apr;5(4):797-807, Molecular & cellular biology
— id: 14440, year: 1985, vol: 5, page: 797, stat: Journal Article,

Common regulatory elements control gene expression from polyoma early and late promoters in cells transformed by chimeric plasmids
Kern FG; Dailey L; Basilico C
1985 Aug;5(8):2070-2079, Molecular & cellular biology
— id: 14438, year: 1985, vol: 5, page: 2070, stat: Journal Article,

The mechanism of cell transformation by SV40 and polyoma virus
Basilico C
1984 ;26(2):235-272, Pharmacology & therapeutics
— id: 14445, year: 1984, vol: 26, page: 235, stat: Journal Article,

Deletion of the origin of replication impairs the ability of polyomavirus DNA to transform cells and to form tandem insertions
Dailey L; Pellegrini S; Basilico C
1984 Mar;49(3):984-987, Journal of virology
— id: 14444, year: 1984, vol: 49, page: 984, stat: Journal Article,

Inhibition of polyoma gene expression in transformed mouse cells by hypermethylation
Liboi E; Basilico C
1984 Jun;135(2):440-451, Virology
— id: 14442, year: 1984, vol: 135, page: 440, stat: Journal Article,

New rat cell line that is highly susceptible to transformation by several oncogenes
Liboi E; Caruso M; Basilico C
1984 Dec;4(12):2925-2928, Molecular & cellular biology
— id: 14441, year: 1984, vol: 4, page: 2925, stat: Journal Article,

Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication
Pellegrini S; Dailey L; Basilico C
1984 Apr;36(4):943-949, Cell
— id: 14443, year: 1984, vol: 36, page: 943, stat: Journal Article,

Changes in the levels of viral and cellular gene-transcripts in the cell cycle of SV40 transformed mouse cells
La Bella F; Brown EH; Basilico C
1983 Oct;117(1):62-68, Journal of cellular physiology
— id: 14446, year: 1983, vol: 117, page: 62, stat: Journal Article,

Induction of sister chromatid exchange by polyoma large viral tumor antigen in transformed rat fibroblasts
Brown EH; Basilico C
1982 May;42(5):1909-1912, Cancer research
— id: 14450, year: 1982, vol: 42, page: 1909, stat: Journal Article,

Requirements for excision and amplification of integrated viral DNA molecules in polyoma virus-transformed cells
Colantuoni V; Dailey L; Valle GD; Basilico C
1982 Aug;43(2):617-628, Journal of virology
— id: 14449, year: 1982, vol: 43, page: 617, stat: Journal Article,

The evolution of polyoma-transformed rat cell lines during propagation in vitro
Dailey L; Colantuoni V; Fenton RG; La Bella F; Zouzias D; Gattoni S; Basilico C
1982 Jan 15;116(1):207-220, Virology
— id: 14451, year: 1982, vol: 116, page: 207, stat: Journal Article,

Changes in the topography of early region transcription during polyoma virus lytic infection
Fenton RG; Basilico C
1982 Dec;79(23):7142-7146, Proceedings of the National Academy of Sciences of the United States of America
— id: 14447, year: 1982, vol: 79, page: 7142, stat: Journal Article,

Regulation of polyoma virus early transcription in transformed cells by large T-antigen
Fenton RG; Basilico C
1982 Sep;121(2):384-392, Virology
— id: 14448, year: 1982, vol: 121, page: 384, stat: Journal Article,

Cell transformation mediated by chromosomal deoxyribonucleic acid of polyoma virus-transformed cells
Della Valle G; Fenton RG; Basilico C
1981 May;1(5):418-425, Molecular & cellular biology
— id: 11453, year: 1981, vol: 1, page: 418, stat: Journal Article,

Polyoma large T antigen regulates the integration of viral DNA sequences into the genome of transformed cells
Della Valle G; Fenton RG; Basilico C
1981 Feb;23(2):347-355, Cell
— id: 14453, year: 1981, vol: 23, page: 347, stat: Journal Article,

Viral gene expression in polyoma virus-transformed rat cells and their cured revertants
Fenton RG; Basilico C
1981 Oct;40(1):150-163, Journal of virology
— id: 14452, year: 1981, vol: 40, page: 150, stat: Journal Article,

Integration and excision of polyoma virus genomes
Basilico C; Zouzias D; Della-Valle G; Gattoni S; Colantuoni V; Fenton R; Dailey L
1980 ;44 Pt 1:611-620, Cold Spring Harbor symposia on quantitative biology
— id: 14459, year: 1980, vol: 44 Pt 1, page: 611, stat: Journal Article,

Amplification of integrated viral DNA sequences in polyoma virus-transformed cells
Colantuoni V; Dailey L; Basilico C
1980 Jul;77(7):3850-3854, Proceedings of the National Academy of Sciences of the United States of America
— id: 14456, year: 1980, vol: 77, page: 3850, stat: Journal Article,

Decreased initiation of DNA synthesis in a temperature-sensitive mutant of hamster cells
Eilen E; Hand R; Basilico C
1980 Nov;105(2):259-266, Journal of cellular physiology
— id: 14454, year: 1980, vol: 105, page: 259, stat: Journal Article,

Relationship between integrated and nonintegrated viral DNA in rat cells transformed by polyoma virus
Gattoni S; Colantuoni V; Basilico C
1980 Jun;34(3):615-626, Journal of virology
— id: 14458, year: 1980, vol: 34, page: 615, stat: Journal Article,

DECREASED INITIATION OF DNA-REPLICATION IN A TEMPERATURE- SENSITIVE MUTANT OF HAMSTER-CELLS
Hand, R; Eilen, E; Basilico, C
1980 ;28(2):A526-A526, Clinical research
— id: 28121, year: 1980, vol: 28, page: A526, stat: Journal Article,

A temperature-sensitive mutation affecting S-phase progression can lead to accumulation of cells with a G2 DNA content
Nishimoto T; Takahashi T; Basilico C
1980 Jul;6(4):465-476, Somatic cell genetics
— id: 14457, year: 1980, vol: 6, page: 465, stat: Journal Article,

Human fibroblasts transformed by the early region of SV40 DNA: analysis of "free" viral DNA sequences
Zouzias D; Jha KK; Mulder C; Basilico C; Ozer HL
1980 Jul 30;104(2):439-453, Virology
— id: 14455, year: 1980, vol: 104, page: 439, stat: Journal Article,

Loss of integrated viral DNA sequences in polyomatransformed cells is associated with an active viral A function
Basilico C; Gattoni S; Zouzias D; Valle GD
1979 Jul;17(3):645-659, Cell
— id: 14460, year: 1979, vol: 17, page: 645, stat: Journal Article,

T-antigen expression in proliferating and non-proliferating simian virus 40-transformed mouse cells
Zouzias D; Basilico C
1979 Jun;30(3):711-719, Journal of virology
— id: 14461, year: 1979, vol: 30, page: 711, stat: Journal Article,

Selective production of cell cycle specific ts mutants
Basilico C
1978 Jun;95(3):367-372, Journal of cellular physiology
— id: 14465, year: 1978, vol: 95, page: 367, stat: Journal Article,

G1 ARREST AND PREMATURE CHROMOSOME CONDENSATION IN A TS DNA MUTANT OF BHK CELLS
Eilen, E; Nishimoto, T; Basilico, C
1978 ;79(2):A4-A4, Journal of cell biology
— id: 29869, year: 1978, vol: 79, page: A4, stat: Journal Article,

Analysis of a method for selecting temperature-sensitive mutants of BHK cells
Nishimoto T; Basilico C
1978 May;4(3):323-340, Somatic cell genetics
— id: 14466, year: 1978, vol: 4, page: 323, stat: Journal Article,

Premature of chromosome condensation in a ts DNA- mutant of BHK cells
Nishimoto T; Eilen E; Basilico C
1978 Oct;15(2):475-483, Cell
— id: 14463, year: 1978, vol: 15, page: 475, stat: Journal Article,

Nonintegrated viral DNA in rat cells doubly transformed by SV40 and polyoma virus
Prasad I; Zouzias D; Basilico C
1978 Mar;85(1):328-331, Virology
— id: 14468, year: 1978, vol: 85, page: 328, stat: Journal Article,

Requirements of BHK cells for the exit from different quiescent states
Talavera A; Basilico C
1978 Dec;97(3 Pt 2 Suppl 1):429-439, Journal of cellular physiology
— id: 14462, year: 1978, vol: 97, page: 429, stat: Journal Article,

Synthesis of H1 histones by BHK cells in G1
Tarnowka MA; Baglioni C; Basilico C
1978 Sep;15(1):163-171, Cell
— id: 14464, year: 1978, vol: 15, page: 163, stat: Journal Article,

Regulation of viral functions in simian virus 40-transformed cells
Zouzias D; Basilico C
1978 May;(48):239-244, National Cancer Institute monograph
— id: 14467, year: 1978, vol: , page: 239, stat: Journal Article,

REGULATION OF VIRAL FUNCTIONS IN SV40-TRANSFORMED MOUSE CELLS
Zouzias, DC; Basilico, C
1978 ;37(6):1746-1746, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 29910, year: 1978, vol: 37, page: 1746, stat: Journal Article,

Temperature-sensitive mutations in animal cells
Basilico C
1977 ;24:223-266, Advances in cancer research
— id: 14473, year: 1977, vol: 24, page: 223, stat: Journal Article,

Suppression of production of mouse 28S ribosomal RNA in mouse-human hybrids segregating mouse chromosomes
Croce CM; Talavera A; Basilico C; Miller OJ
1977 Feb;74(2):694-697, Proceedings of the National Academy of Sciences of the United States of America
— id: 14472, year: 1977, vol: 74, page: 694, stat: Journal Article,

Expression of the SV40-transformed phenotype in hybrids between conditional and wild-type transformants
Rovigatti U; Basilico C
1977 May;106(2):277-284, Experimental cell research
— id: 14471, year: 1977, vol: 106, page: 277, stat: Journal Article,

Temperature sensitive mutants of BHK cells affected in cell cycle progression
Talavera A; Basilico C
1977 Sep;92(3):425-436, Journal of cellular physiology
— id: 14470, year: 1977, vol: 92, page: 425, stat: Journal Article,

State of the viral DNA in rat cells transformed by polyma virus. II. Identification of the cells containing nonintegrated viral DNA and the effect of viral mutations
Zouzias D; Prasad I; Basilico C
1977 Oct;24(1):142-150, Journal of virology
— id: 14469, year: 1977, vol: 24, page: 142, stat: Journal Article,

Regulation of viral transciption and tumor antigen expression in cells transformed by simian virus 40
Basilico C; Zouzias D
1976 Jun;73(6):1931-1935, Proceedings of the National Academy of Sciences of the United States of America
— id: 14474, year: 1976, vol: 73, page: 1931, stat: Journal Article,

Transcriptional activity and chromatin structural changes in a temperature-sensitive mutant of BHK cells blocked in early G1
Kane G; Basilico C; Basterga R
1976 Apr;99(1):165-173, Experimental cell research
— id: 14477, year: 1976, vol: 99, page: 165, stat: Journal Article,

State of the viral DNA in rat cells transformed by polyoma virus. I. Virus rescue and the presence of nonintergrated viral DNA molecules
Prasad I; Zouzias D; Basilico C
1976 May;18(2):436-444, Journal of virology
— id: 14475, year: 1976, vol: 18, page: 436, stat: Journal Article,

STATE OF FREE VIRAL-DNA IN RAT CELLS TRANSFORMED BY POLYOMA- VIRUS
Prasad, I; Zouzias, D; Basilico, C
1976 ;70(2):A67-A67, Journal of cell biology
— id: 29449, year: 1976, vol: 70, page: A67, stat: Journal Article,

Imperfect complementation in human-hamster somatic cell hybrids
Talavera A; Basilico C; Croce CM
1976 Feb 26;259(5545):667-670, Nature
— id: 14478, year: 1976, vol: 259, page: 667, stat: Journal Article,

ISOLATION AND CHARACTERIZATION OF CELL-CYCLE MUTANTS OF BHK
Talavera, A; Nishimoto, T; Basilico, C
1976 ;70(2):A341-A341, Journal of cell biology
— id: 28741, year: 1976, vol: 70, page: A341, stat: Journal Article,

Processing of ribosomal RNA in a temperature sensitive mutant of BHK cells
Toniolo D; Basilico C
1976 Apr 2;425(4):409-418, Biochimica & biophysica acta
— id: 14476, year: 1976, vol: 425, page: 409, stat: Journal Article,

REGULATION OF T-ANTIGEN AND VIRAL-RNA SYNTHESIS IN SV40- TRANSFORMED CELLS
Zouzias, DC; Basilico, C
1976 ;35(7):1688-1688, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 29475, year: 1976, vol: 35, page: 1688, stat: Journal Article,

Transformation by polyoma virus alters expression of a cell mutation affecting cycle traverse
Burstin SJ; Basilico C
1975 Jul;72(7):2540-2544, Proceedings of the National Academy of Sciences of the United States of America
— id: 14479, year: 1975, vol: 72, page: 2540, stat: Journal Article,

Temperature-sensitive cell mutations that inhibit adenovirus 2 replication
Nishimoto T; Raskas HJ; Basilico C
1975 Jan;72(1):328-332, Proceedings of the National Academy of Sciences of the United States of America
— id: 14481, year: 1975, vol: 72, page: 328, stat: Journal Article,

INTEGRATION OF SV40
Prasad, I; Basilico, C
1975 ;16(MAR):20-20, Proceedings (American Association for Cancer Research)
— id: 28665, year: 1975, vol: 16, page: 20, stat: Journal Article,

SV40-transformed cells with temperature-dependent serum requirements
Toniolo D; Basilico C
1975 Mar;4(3):255-262, Cell
— id: 14480, year: 1975, vol: 4, page: 255, stat: Journal Article,

Mutant of polyoma virus with impaired adsorption to BHK cells
Basilico C; DiMayorca G
1974 Apr;13(4):931-934, Journal of virology
— id: 14484, year: 1974, vol: 13, page: 931, stat: Journal Article,

Methods for selecting and studying temperature-sensitive mutants of BHK-21 cells
Basilico C; Meiss HK
1974 ;8(0):1-22, Methods in cell biology
— id: 14486, year: 1974, vol: 8, page: 1, stat: Journal Article,

A temperature-sensitive cell cycle mutant of the BHK cell line
Burstin SJ; Meiss HK; Basilico C
1974 Dec;84(3):397-408, Journal of cellular physiology
— id: 14482, year: 1974, vol: 84, page: 397, stat: Journal Article,

Cyclic AMP levels in temperature sensitive SV40 transformed cell lines
Burstin SJ; Renger HC; Basilico C
1974 Aug;84(1):69-73, Journal of cellular physiology
— id: 14483, year: 1974, vol: 84, page: 69, stat: Journal Article,

TEMPERATURE SENSITIVE MUTATION OF BHK 21 CELLS
Burstin, SJ; Meiss, HK; Basilico, C
1974 ;63(2):A44-A44, Journal of cell biology
— id: 28421, year: 1974, vol: 63, page: A44, stat: Journal Article,

Complementation of a defect in the production of ribosomal RNA in somatic cell hybrids
Toniolo D; Basilico C
1974 Mar 29;248(447):411-413, Nature
— id: 14485, year: 1974, vol: 248, page: 411, stat: Journal Article,

TEMPERATURE-SENSITIVE MUTANTS OF MAMMALIAN SOMATIC-CELLS
BASILICO, C
1973 ;35(2):181-182, Transactions of the New York Academy of Sciences
— id: 39808, year: 1973, vol: 35, page: 181, stat: Journal Article,

Surface changes in temperature-sensitive Simian virus 40-transformed cells
Noonan KD; Renger HC; Basilico C; Burger MM
1973 Feb;70(2):347-349, Proceedings of the National Academy of Sciences of the United States of America
— id: 14489, year: 1973, vol: 70, page: 347, stat: Journal Article,

Temperature-sensitive simian virus 40-transformed cells: phenomena accompanying transition from the transformed to the "normal" state
Renger HC; Basilico C
1973 May;11(5):702-708, Journal of virology
— id: 14487, year: 1973, vol: 11, page: 702, stat: Journal Article,

A temperature-sensitive mutation affecting 28S ribosomal RNA production in mammalian cells
Toniolo D; Meiss HK; Basilico C
1973 Apr;70(4):1273-1277, Proceedings of the National Academy of Sciences of the United States of America
— id: 14488, year: 1973, vol: 70, page: 1273, stat: Journal Article,

Temperature sensitive mutants of BHK 21 cells
Meiss HK; Basilico C
1972 Sep 20;239(90):66-68, Nature: new biology
— id: 14490, year: 1972, vol: 239, page: 66, stat: Journal Article,

Mutation causing temperature-sensitive expression of cell transformation by a tumor virus (SV40-3T3 mouse cells-growth control)
Renger HC; Basilico C
1972 Jan;69(1):109-114, Proceedings of the National Academy of Sciences of the United States of America
— id: 14491, year: 1972, vol: 69, page: 109, stat: Journal Article,

Multiplication of polyoma virus in mouse-hamster somatic hybrids: a hybrid cell line which produces viral particles containing predominantly host deoxyribonucleic acid
Basilico, C; Burstin, S J
1971 Jun;7(6):802-812, Journal of virology
— id: 14492, year: 1971, vol: 7, page: 802, stat: Journal Article,

Susceptibility to superinfection of hybrids between polyoma "transformed" BHK and "normal" 3T3 cells
Basilico, C; Wang, R
1971 Mar 24;230(12):105-107, Nature: new biology
— id: 14494, year: 1971, vol: 230, page: 105, stat: Journal Article,

Mammalian somatic cell hybrids and their susceptibility to viral infection
Green, H; Wang, R; Basilico, C; Pollack, R; Kusano, T; Salas, J
1971 May-Jun;30(3):930-934, Federation Proceedings (Federation of American Societies for Experimental Biology)
— id: 14493, year: 1971, vol: 30, page: 930, stat: Journal Article,

Induction of mitochondrial DNA synthesis by polyoma virus
Vesco, C; Basilico, C
1971 Jan 29;229(5283):336-338, Nature
— id: 14495, year: 1971, vol: 229, page: 336, stat: Journal Article,

The interaction of polyoma virus with mouse-hamster somatic hybrid cells
Basilico C; Matsuya Y; Green H
1970 Jun;41(2):295-305, Virology
— id: 14496, year: 1970, vol: 41, page: 295, stat: Journal Article,

Origin of the thymidine kinase induced by polyoma virus in productively infected cells
Basilico C; Matsuya Y; Green H
1969 Feb;3(2):140-145, Journal of virology
— id: 14498, year: 1969, vol: 3, page: 140, stat: Journal Article,

Electron microscopic studies of polyoma DNA released in protein monolayers
Vasquez C; Kleinschmidt AK; Basilico C
1969 Jul 28;43(2):317-325, Journal of molecular biology
— id: 14497, year: 1969, vol: 43, page: 317, stat: Journal Article,

Studies on a temperature-sensitive mutant of vaccinia virus strain WR
Basilico C; Joklik WK
1968 Dec;36(4):668-677, Virology
— id: 14500, year: 1968, vol: 36, page: 668, stat: Journal Article,

Properties and uses of human-mouse hybrid cell lines
Matsuya Y; Green H; Basilico C
1968 Dec 21;220(173):1199-1202, Nature
— id: 14499, year: 1968, vol: 220, page: 1199, stat: Journal Article,

Effect of the inhibition of protein synthesis on the establishment of transformation by polyoma virus
Marin G; Basilico C
1967 Feb;1(1):120-127, Journal of virology
— id: 14502, year: 1967, vol: 1, page: 120, stat: Journal Article,

Transformation of polyploid hamster cells by polyoma virus
Marin G; Basilico C
1967 Oct 7;216(110):62-63, Nature
— id: 14501, year: 1967, vol: 216, page: 62, stat: Journal Article,

Requirement for the integrity of the viral genome for the induction of host DNA synthesis by polyoma virus
Basilico C; Marin G; Mayorca G di
1966 Jul;56(1):208-215, Proceedings of the National Academy of Sciences of the United States of America
— id: 14504, year: 1966, vol: 56, page: 208, stat: Journal Article,

Infection of thymidine kinase-deficient BHK cells with polyoma virus
Littlefield JW; Basilico C
1966 Jul 16;211(46):250-252, Nature
— id: 14503, year: 1966, vol: 211, page: 250, stat: Journal Article,

Radiation target size of the lytic and the transforming ability of polyoma virus
Basilico C; Di Mayorca G
1965 Jul;54(1):125-127, Proceedings of the National Academy of Sciences of the United States of America
— id: 14505, year: 1965, vol: 54, page: 125, stat: Journal Article,