Dafna Bar-Sagi

Biosketch / Results /

Dafna Bar-Sagi, Ph.D.

Professor; Senior Vice President and Vice Dean for Science, Chief Scientific Officer; Professor, Department of Biochemistry
Departments of Biochemistry and Molecular Pharmacology and Medicine (Medicine)

Contact Info

Address

Floor 2 Room 210
Smilow Research Building
New York, NY 10016

212-263-2095
Dafna.Bar-Sagi@nyumc.org

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Education

1984 — SUNY @ Stony Brook, Graduate Education
1984-1987 — Cold Spring Harbor, PostDoctoral Training

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Research Summary

The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.

Research Keywords

Ras, signal transduction, cancer, inflammation

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Determining the macropinocytic index of cells through a quantitative image-based assay
Commisso, Cosimo; Flinn, Rory J; Bar-Sagi, Dafna
2014 Jan;9(1):182-192, Nature protocols
— id: 759812, year: 2014, vol: 9, page: 182, stat: Journal Article,

Wild-type h- and N-ras promote mutant k-ras-driven tumorigenesis by modulating the DNA damage response
Grabocka, Elda; Pylayeva-Gupta, Yuliya; Jones, Mathew J K; Lubkov, Veronica; Yemanaberhan, Eyoel; Taylor, Laura; Jeng, Hao Hsuan; Bar-Sagi, Dafna
2014 Feb;25(2):243-256, Cancer cell
— id: 811132, year: 2014, vol: 25, page: 243, stat: Journal Article,

E-cadherin-mediated cell coupling is required for apoptotic cell extrusion
Lubkov, Veronica; Bar-Sagi, Dafna
2014 Apr;24(8):868-874, Current biology. CB
— id: 881902, year: 2014, vol: 24, page: 868, stat: Journal Article,

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, Cosimo; Davidson, Shawn M; Soydaner-Azeloglu, Rengin G; Parker, Seth J; Kamphorst, Jurre J; Hackett, Sean; Grabocka, Elda; Nofal, Michel; Drebin, Jeffrey A; Thompson, Craig B; Rabinowitz, Joshua D; Metallo, Christian M; Vander Heiden, Matthew G; Bar-Sagi, Dafna
2013 May;497(7451):633-637, Nature
— id: 361712, year: 2013, vol: 497, page: 633, stat: Journal Article,

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression
Court, Helen; Amoyel, Marc; Hackman, Michael; Lee, Kyoung Eun; Xu, Ruliang; Miller, George; Bar-Sagi, Dafna; Bach, Erika A; Bergo, Martin O; Philips, Mark R
2013 Oct;:182-192, Journal of clinical investigation
— id: 761382, year: 2013, vol: , page: 182, stat: Journal Article,

Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer
Dultz, Linda A; Dhar, Shumon; Ogilvie, Jennifer B; Heller, Keith S; Bar-Sagi, Dafna; Patel, Kepal N
2013 Dec;154(6):1239-1245, Surgery
— id: 629882, year: 2013, vol: 154, page: 1239, stat: Journal Article,

An Orthosteric Inhibitor of the RAS-SOS Interaction
Nickerson, Seth; Joy, Stephen T; Arora, Paramjit S; Bar-Sagi, Dafna
2013 ;34:25-39, The enzymes
— id: 1071202, year: 2013, vol: 34, page: 25, stat: Journal Article,

Microdissection and culture of murine pancreatic ductal epithelial cells
Pylayeva-Gupta, Yuliya; Lee, Kyoung Eun; Bar-Sagi, Dafna
2013 ;980:267-279, Methods in molecular biology
— id: 214132, year: 2013, vol: 980, page: 267, stat: Journal Article,

Regulating the regulator: post-translational modification of RAS
Ahearn, Ian M; Haigis, Kevin; Bar-Sagi, Dafna; Philips, Mark R
2012 Jan;13(1):39-51, Nature reviews. Molecular cell biology
— id: 147707, year: 2012, vol: 13, page: 39, stat: Journal Article,

VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
Cao, Ying; E, Guangqi; Wang, Enfeng; Pal, Krishnendu; Dutta, Shamit K; Bar-Sagi, Dafna; Mukhopadhyay, Debabrata
2012 Aug;72(16):3912-3918, Cancer research
— id: 174384, year: 2012, vol: 72, page: 3912, stat: Journal Article,

Glutamine addiction: Recognizing and harnessing the pathometabolic potential of Ras-mediated macropinocytosis
Commisso, C; Soydaner-Azeloglu, R G; Bar-Sagi, D
2012 15 Apr 2012;72(8):-, Cancer research
— id: 422392, year: 2012, vol: 72, page: , stat: Journal Article,

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
Jeng, Hao-Hsuan; Taylor, Laura J; Bar-Sagi, Dafna
2012 ;3:1168-1168, Nature communications
— id: 202202, year: 2012, vol: 3, page: 1168, stat: Journal Article,

EZH2 couples pancreatic regeneration to neoplastic progression
Mallen-St Clair, Jon; Soydaner-Azeloglu, Rengin; Lee, Kyoung Eun; Taylor, Laura; Livanos, Alexandra; Pylayeva-Gupta, Yuliya; Miller, George; Margueron, Raphael; Reinberg, Danny; Bar-Sagi, Dafna
2012 Mar;26(5):439-444, Genes & development
— id: 159852, year: 2012, vol: 26, page: 439, stat: Journal Article,

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
Ochi, Atsuo; Nguyen, Andrew H; Bedrosian, Andrea S; Mushlin, Harry M; Zarbakhsh, Saman; Barilla, Rocky; Zambirinis, Constantinos P; Fallon, Nina C; Rehman, Adeel; Pylayeva-Gupta, Yuliya; Badar, Sana; Hajdu, Cristina H; Frey, Alan B; Bar-Sagi, Dafna; Miller, George
2012 Aug;209(9):1671-1687, Journal of experimental medicine
— id: 177029, year: 2012, vol: 209, page: 1671, stat: Journal Article,

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia
Pylayeva-Gupta, Yuliya; Lee, Kyoung Eun; Hajdu, Cristina H; Miller, George; Bar-Sagi, Dafna
2012 Jun;21(6):836-847, Cancer cell
— id: 169485, year: 2012, vol: 21, page: 836, stat: Journal Article,

Regulation of RAS oncogenicity by acetylation
Yang, Moon Hee; Nickerson, Seth; Kim, Eric T; Liot, Caroline; Laurent, Gaelle; Spang, Robert; Philips, Mark R; Shan, Yibing; Shaw, David E; Bar-Sagi, Dafna; Haigis, Marcia C; Haigis, Kevin M
2012 Jul;109(27):10843-10848, Proceedings of the National Academy of Sciences of the United States of America
— id: 173075, year: 2012, vol: 109, page: 10843, stat: Journal Article,

CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling
Zheng, Z-Y; Cheng, C-M; Fu, X-R; Chen, L-Y; Xu, L; Terrillon, S; Wong, S T; Bar-Sagi, D; Songyang, Z; Chang, E C
2012 Oct;31(43):4630-4638, Oncogene
— id: 184602, year: 2012, vol: 31, page: 4630, stat: Journal Article,

Escorting ras
Zheng, Ze-Yi; Xu, Lizhong; Bar-Sagi, Dafna; Chang, Eric C
2012 Oct;3(4):236-239, Small GTPases
— id: 210812, year: 2012, vol: 3, page: 236, stat: Journal Article,

Fibronectin growth factor-binding domains are required for fibroblast survival
Lin, Fubao; Ren, Xiang-Dong; Pan, Zhi; Macri, Lauren; Zong, Wei-Xing; Tonnesen, Marcia G; Rafailovich, Miriam; Bar-Sagi, Dafna; Clark, Richard A F
2011 Jan;131(1):84-98, Journal of investigative dermatology
— id: 138146, year: 2011, vol: 131, page: 84, stat: Journal Article,

An orthosteric inhibitor of the Ras-Sos interaction
Patgiri, Anupam; Yadav, Kamlesh K; Arora, Paramjit S; Bar-Sagi, Dafna
2011 ;7(9):585-587, Nature chemical biology
— id: 137095, year: 2011, vol: 7, page: 585, stat: Journal Article,

RAS oncogenes: weaving a tumorigenic web
Pylayeva-Gupta, Yuliya; Grabocka, Elda; Bar-Sagi, Dafna
2011 ;11(11):761-774, Nature reviews. Cancer
— id: 139741, year: 2011, vol: 11, page: 761, stat: Journal Article,

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor
Connolly, Michael K; Mallen-St Clair, Jon; Bedrosian, Andrea S; Malhotra, Ashim; Vera, Valery; Ibrahim, Junaid; Henning, Justin; Pachter, H Leon; Bar-Sagi, Dafna; Frey, Alan B; Miller, George
2010 Apr;87(4):713-725, Journal of leukocyte biology
— id: 108918, year: 2010, vol: 87, page: 713, stat: Journal Article,

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Gureasko, Jodi; Kuchment, Olga; Makino, Debora Lika; Sondermann, Holger; Bar-Sagi, Dafna; Kuriyan, John
2010 Feb 23;107(8):3430-3435, Proceedings of the National Academy of Sciences of the United States of America
— id: 111558, year: 2010, vol: 107, page: 3430, stat: Journal Article,

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
Lee, Kyoung Eun; Bar-Sagi, Dafna
2010 Nov 16;18(5):448-458, Cancer cell
— id: 114515, year: 2010, vol: 18, page: 448, stat: Journal Article,

Signaling endosomes: seeing is believing
Miaczynska, Marta; Bar-Sagi, Dafna
2010 Aug;22(4):535-540, Current opinion in cell biology
— id: 111557, year: 2010, vol: 22, page: 535, stat: Journal Article,

Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b
Nimnual AS; Taylor LJ; Nyako M; Jeng HH; Bar-Sagi D
2010 Sep;1(2):89-97, Small GTPases
— id: 138351, year: 2010, vol: 1, page: 89, stat: Journal Article,

Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination
Xu, Lizhong; Lubkov, Veronica; Taylor, Laura J; Bar-Sagi, Dafna
2010 Aug 10;20(15):1372-1377, Current biology. CB
— id: 138182, year: 2010, vol: 20, page: 1372, stat: Journal Article,

Spry2 expression correlates with BRAF mutation in thyroid cancer
Xu, Lizhong; Zhou, Jun Liang; Cohen, Michael; Bar-Sagi, Dafna; Patel, Kepal N
2010 Dec;148(6):1282-7; discussion 1287, Surgery
— id: 115281, year: 2010, vol: 148, page: 1282, stat: Journal Article,

Allosteric gating of Son of sevenless activity by the histone domain
Yadav, Kamlesh K; Bar-Sagi, Dafna
2010 Feb 23;107(8):3436-3440, Proceedings of the National Academy of Sciences of the United States of America
— id: 107379, year: 2010, vol: 107, page: 3436, stat: Journal Article,

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha
Connolly, Michael K; Bedrosian, Andrea S; Mallen-St Clair, Jon; Mitchell, Aaron P; Ibrahim, Junaid; Stroud, Andrea; Pachter, H Leon; Bar-Sagi, Dafna; Frey, Alan B; Miller, George
2009 Nov;119(11):3213-3225, Journal of clinical investigation
— id: 105172, year: 2009, vol: 119, page: 3213, stat: Journal Article,

Ras/MAPK signaling from endomembranes
Fehrenbacher, Nicole; Bar-Sagi, Dafna; Philips, Mark
2009 Aug;3(4):297-307, Molecular oncology
— id: 101955, year: 2009, vol: 3, page: 297, stat: Journal Article,

Characterization of a Ras mutant with identical GDP- and GTP-bound structures
Ford, Bradley; Boykevisch, Sean; Zhao, Chen; Kunzelmann, Simone; Bar-Sagi, Dafna; Herrmann, Christian; Nassar, Nicolas
2009 Dec 8;48(48):11449-11457, Biochemistry
— id: 105530, year: 2009, vol: 48, page: 11449, stat: Journal Article,

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
Frank, Matthew J; Dawson, David W; Bensinger, Steven J; Hong, Jason S; Knosp, Wendy M; Xu, Lizhong; Balatoni, Cynthia E; Allen, Eric L; Shen, Rhine R; Bar-Sagi, Dafna; Martin, Gail R; Teitell, Michael A
2009 Mar 12;113(11):2478-2487, Blood
— id: 95089, year: 2009, vol: 113, page: 2478, stat: Journal Article,

Raf-1 and squamous cell carcinoma: Rok-ing the boat
Grabocka, Elda; Bar-Sagi, Dafna
2009 Aug 4;16(2):85-86, Cancer cell
— id: 101331, year: 2009, vol: 16, page: 85, stat: Journal Article,

Abstracts of papers presented at the 2008 meeting on mechanisms and models of cancer
Bar-Sagi, Dafna; De Pinho, Ronald A; Lees, Jacqueline; Sherr, Charles J
Cold Spring Harbor NY : Cold Spring Harbor Laboratory, 2008,
— id: 2081, year: 2008, vol: , page: , stat: ,

PROLONGED EXPOSURE TO HIGH FAT DIET AND HYPERLIPIDEMIA IN MICE EXACERBATES ACUTE PANCREATITIS
Clair, JMS; Joaquin, VA; Fisher, EA; Bar-Sagi, D
2008 NOV ;37(4):482-483, Pancreas
— id: 91327, year: 2008, vol: 37, page: 482, stat: Journal Article,

Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
Garcia, Avalon; Zheng, Yang; Zhao, Chen; Toschi, Alfredo; Fan, Judy; Shraibman, Natalie; Brown, H Alex; Bar-Sagi, Dafna; Foster, David A; Arbiser, Jack L
2008 Jul 1;14(13):4267-4274, Clinical cancer research
— id: 95091, year: 2008, vol: 14, page: 4267, stat: Journal Article,

Membrane-dependent signal integration by the Ras activator Son of sevenless
Gureasko, Jodi; Galush, William J; Boykevisch, Sean; Sondermann, Holger; Bar-Sagi, Dafna; Groves, Jay T; Kuriyan, John
2008 May;15(5):452-461, Nature structural & molecular biology
— id: 95093, year: 2008, vol: 15, page: 452, stat: Journal Article,

Design, synthesis, and biological evaluation of new-generation taxoids
Ojima, Iwao; Chen, Jin; Sun, Liang; Borella, Christopher P; Wang, Tao; Miller, Michael L; Lin, Songnian; Geng, Xudong; Kuznetsova, Larisa; Qu, Chuanxing; Gallager, David; Zhao, Xianrui; Zanardi, Ilaria; Xia, Shujun; Horwitz, Susan B; Mallen-St Clair, Jon; Guerriero, Jennifer L; Bar-Sagi, Dafna; Veith, Jean M; Pera, Paula; Bernacki, Ralph J
2008 Jun 12;51(11):3203-3221, Journal of medicinal chemistry
— id: 95092, year: 2008, vol: 51, page: 3203, stat: Journal Article,

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways
Qi, Jianfei; Nakayama, Koh; Gaitonde, Supriya; Goydos, James S; Krajewski, Stan; Eroshkin, Alexey; Bar-Sagi, Dafna; Bowtell, David; Ronai, Ze'ev
2008 Oct 28;105(43):16713-16718, Proceedings of the National Academy of Sciences of the United States of America
— id: 95090, year: 2008, vol: 105, page: 16713, stat: Journal Article,

Compartmentalization-dependent ubiquitination of oncogenic Ras regulates transforming activity
Terrillon, S; Bar-Sagi, D
2008 JUN ;275(1):320-320, FEBS journal
— id: 86954, year: 2008, vol: 275, page: 320, stat: Journal Article,

Biochemical and biophysical analyses of Ras modification by ubiquitin
Terrillon, Sonia; Bar-Sagi, Dafna
2008 ;438:259-276, Methods in enzymology
— id: 79302, year: 2008, vol: 438, page: 259, stat: Journal Article,

Hyperlipidemia causes pancreatic inflammation and ductal proliferation in Apolipoprotein E deficient mice
Clair, JMS; Joaquin, VA; Fisher, EA; Bar-Sagi, D
2007 NOV ;35(4):414-415, Pancreas
— id: 75691, year: 2007, vol: 35, page: 414, stat: Journal Article,

Spatial Regulation of EGFR Signaling by Sprouty2
Kim, Hong Joo; Taylor, Laura J; Bar-Sagi, Dafna
2007 Mar 6;17(5):455-461, Current biology. CB
— id: 70959, year: 2007, vol: 17, page: 455, stat: Journal Article,

Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Tartaglia, Marco; Pennacchio, Len A; Zhao, Chen; Yadav, Kamlesh K; Fodale, Valentina; Sarkozy, Anna; Pandit, Bhaswati; Oishi, Kimihiko; Martinelli, Simone; Schackwitz, Wendy; Ustaszewska, Anna; Martin, Joel; Bristow, James; Carta, Claudio; Lepri, Francesca; Neri, Cinzia; Vasta, Isabella; Gibson, Kate; Curry, Cynthia J; Siguero, Juan Pedro Lopez; Digilio, Maria Cristina; Zampino, Giuseppe; Dallapiccola, Bruno; Bar-Sagi, Dafna; Gelb, Bruce D
2007 Feb;39(2):276-276, Nature genetics
— id: 70960, year: 2007, vol: 39, page: 276, stat: Journal Article,

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Tartaglia, Marco; Pennacchio, Len A; Zhao, Chen; Yadav, Kamlesh K; Fodale, Valentina; Sarkozy, Anna; Pandit, Bhaswati; Oishi, Kimihiko; Martinelli, Simone; Schackwitz, Wendy; Ustaszewska, Anna; Martin, Joel; Bristow, James; Carta, Claudio; Lepri, Francesca; Neri, Cinzia; Vasta, Isabella; Gibson, Kate; Curry, Cynthia J; Siguero, Juan Pedro Lopez; Digilio, Maria Cristina; Zampino, Giuseppe; Dallapiccola, Bruno; Bar-Sagi, Dafna; Gelb, Bruce D
2007 Jan;39(1):75-79, Nature genetics
— id: 70962, year: 2007, vol: 39, page: 75, stat: Journal Article,

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Yeh, Brian J; Rutigliano, Robert J; Deb, Anrica; Bar-Sagi, Dafna; Lim, Wendell A
2007 May 31;447(7144):596-600, Nature
— id: 95094, year: 2007, vol: 447, page: 596, stat: Journal Article,

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
Zhao, Chen; Du, Guangwei; Skowronek, Karl; Frohman, Michael A; Bar-Sagi, Dafna
2007 Jun;9(6):706-712, Nature cell biology
— id: 95095, year: 2007, vol: 9, page: 706, stat: Journal Article,

Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems
Agbunag, Cristina; Lee, Kyoung Eun; Buontempo, Serena; Bar-Sagi, Dafna
2006 ;407:703-710, Methods in enzymology
— id: 70966, year: 2006, vol: 407, page: 703, stat: Journal Article,

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen
Archer, Herbert; Jura, Natalia; Keller, James; Jacobson, Matthew; Bar-Sagi, Dafna
2006 Dec;131(6):1844-1855, Gastroenterology
— id: 70963, year: 2006, vol: 131, page: 1844, stat: Journal Article,

Regulation of ras signaling dynamics by Sos-mediated positive feedback
Boykevisch, Sean; Zhao, Chen; Sondermann, Holger; Philippidou, Polyxeni; Halegoua, Simon; Kuriyan, John; Bar-Sagi, Dafna
2006 Nov 7;16(21):2173-2179, Current biology. CB
— id: 70964, year: 2006, vol: 16, page: 2173, stat: Journal Article,

Regulation of sprouty stability by Mnk1-dependent phosphorylation
DaSilva, John; Xu, Lizhong; Kim, Hong Joo; Miller, W Todd; Bar-Sagi, Dafna
2006 Mar;26(5):1898-1907, Molecular & cellular biology
— id: 62919, year: 2006, vol: 26, page: 1898, stat: Journal Article,

A Ras-induced conformational switch in the Ras activator Son of sevenless
Freedman, Tanya S; Sondermann, Holger; Friedland, Gregory D; Kortemme, Tanja; Bar-Sagi, Dafna; Marqusee, Susan; Kuriyan, John
2006 Nov 7;103(45):16692-16697, Proceedings of the National Academy of Sciences of the United States of America
— id: 70965, year: 2006, vol: 103, page: 16692, stat: Journal Article,

Mapping cellular routes of Ras: a ubiquitin trail
Jura, Natalia; Bar-Sagi, Dafna
2006 Dec;5(23):2744-2747, Cell cycle
— id: 70961, year: 2006, vol: 5, page: 2744, stat: Journal Article,

Differential modification of ras proteins by ubiquitination
Jura, Natalia; Scotto-Lavino, Elizabeth; Sobczyk, Aleksander; Bar-Sagi, Dafna
2006 Mar 3;21(5):679-687, Molecular cell
— id: 62917, year: 2006, vol: 21, page: 679, stat: Journal Article,

The role of boundary conditions in the experimental model of wound healing
Nikolic, Djordje L; Boettiger, Alistair N; Bar-Sagi, Dafna; Carbeck, Jeffrey D; Shvartsman, Stanislav Y
2006 Jul;291(1):C68-C75, American journal of physiology. Cell physiology
— id: 62918, year: 2006, vol: 291, page: C68, stat: Journal Article,

Structure of the G60A mutant of Ras: implications for the dominant negative effect
Ford, Bradley; Skowronek, Karlheinz; Boykevisch, Sean; Bar-Sagi, Dafna; Nassar, Nicolas
2005 Jul 8;280(27):25697-25705, Journal of biological chemistry
— id: 62923, year: 2005, vol: 280, page: 25697, stat: Journal Article,

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between
Jura, Natalia; Archer, Herbert; Bar-Sagi, Dafna
2005 Jan;15(1):72-77, Cell research
— id: 62924, year: 2005, vol: 15, page: 72, stat: Journal Article,

Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless
Sondermann, Holger; Nagar, Bhushan; Bar-Sagi, Dafna; Kuriyan, John
2005 Nov 15;102(46):16632-16637, Proceedings of the National Academy of Sciences of the United States of America
— id: 62921, year: 2005, vol: 102, page: 16632, stat: Journal Article,

Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering
Sondermann, Holger; Zhao, Chen; Bar-Sagi, Dafna
2005 Oct;37(2):197-202, Methods
— id: 62920, year: 2005, vol: 37, page: 197, stat: Journal Article,

Ras oncogene and inflammation: partners in crime
Sparmann, Anke; Bar-Sagi, Dafna
2005 Jun;4(6):735-736, Cell cycle
— id: 62922, year: 2005, vol: 4, page: 735, stat: Journal Article,

Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
Agbunag, Cristina; Bar-Sagi, Dafna
2004 Aug 15;64(16):5659-5663, Cancer research
— id: 62927, year: 2004, vol: 64, page: 5659, stat: Journal Article,

Identification of the Role of MnSOD in EGFR-Positive Breast Cancer Development
Kim, Hong J; Bar-Sagi, Dafna
Ft. Belvoir Defense Technical Information Center MAY 2004,
— id: 2307, year: 2004, vol: , page: , stat: ,

Modulation of signalling by Sprouty: a developing story
Kim, Hong Joo; Bar-Sagi, Dafna
2004 Jun;5(6):441-450, Nature reviews. Molecular cell biology
— id: 62928, year: 2004, vol: 5, page: 441, stat: Journal Article,

Structural analysis of autoinhibition in the Ras activator Son of sevenless
Sondermann, Holger; Soisson, Stephen M; Boykevisch, Sean; Yang, Shao-Song; Bar-Sagi, Dafna; Kuriyan, John
2004 Oct 29;119(3):393-405, Cell
— id: 62926, year: 2004, vol: 119, page: 393, stat: Journal Article,

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, Anke; Bar-Sagi, Dafna
2004 Nov;6(5):447-458, Cancer cell
— id: 62925, year: 2004, vol: 6, page: 447, stat: Journal Article,

Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy
Epperly, M W; Guo, H L; Jefferson, M; Nie, S; Gretton, J; Bernarding, M; Bar-Sagi, D; Archer, H; Greenberger, J S
2003 Jan;10(2):163-171, Gene therapy
— id: 62935, year: 2003, vol: 10, page: 163, stat: Journal Article,

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene
Guo, Hongliang; Seixas-Silva, Jose A Jr; Epperly, Michael W; Gretton, Joan E; Shin, Dong M; Bar-Sagi, Dafna; Archer, Herbert; Greenberger, Joel S
2003 Mar;159(3):361-370, Radiation research
— id: 62932, year: 2003, vol: 159, page: 361, stat: Journal Article,

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl
Hall, Amy B; Jura, Natalia; DaSilva, John; Jang, Yeon Joo; Gong, Delquin; Bar-Sagi, Dafna
2003 Feb 18;13(4):308-314, Current biology. CB
— id: 62934, year: 2003, vol: 13, page: 308, stat: Journal Article,

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway
Kennedy, Norman J; Sluss, Hayla K; Jones, Stephen N; Bar-Sagi, Dafna; Flavell, Richard A; Davis, Roger J
2003 Mar 1;17(5):629-637, Genes & development
— id: 62930, year: 2003, vol: 17, page: 629, stat: Journal Article,

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
Margarit, S Mariana; Sondermann, Holger; Hall, Brian E; Nagar, Bhushan; Hoelz, Andre; Pirruccello, Michelle; Bar-Sagi, Dafna; Kuriyan, John
2003 Mar 7;112(5):685-695, Cell
— id: 62931, year: 2003, vol: 112, page: 685, stat: Journal Article,

Redox-dependent downregulation of Rho by Rac
Nimnual, Anjaruwee S; Taylor, Laura J; Bar-Sagi, Dafna
2003 Mar;5(3):236-241, Nature cell biology
— id: 62933, year: 2003, vol: 5, page: 236, stat: Journal Article,

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless
Sondermann, Holger; Soisson, Stephen M; Bar-Sagi, Dafna; Kuriyan, John
2003 Dec;11(12):1583-1593, Structure
— id: 62929, year: 2003, vol: 11, page: 1583, stat: Journal Article,

Ras and Rac as activators of reactive oxygen species (ROS)
Archer, Herbert; Bar-Sagi, Dafna
2002 ;189:67-73, Methods in molecular biology
— id: 62940, year: 2002, vol: 189, page: 67, stat: Journal Article,

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins
Egan, James E; Hall, Amy B; Yatsula, Bogdan A; Bar-Sagi, Dafna
2002 Apr 30;99(9):6041-6046, Proceedings of the National Academy of Sciences of the United States of America
— id: 62943, year: 2002, vol: 99, page: 6041, stat: Journal Article,

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy
Epperly, Michael W; Sikora, Christine A; DeFilippi, Stacy J; Gretton, Joan E; Bar-Sagi, Dafna; Archer, Herbert; Carlos, Timothy; Guo, HongLiang; Greenberger, Joel S
2002 ;8(4):175-187, Biology of blood & marrow transplantation
— id: 62942, year: 2002, vol: 8, page: 175, stat: Journal Article,

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation
Farhang-Fallah, Janet; Randhawa, Varinder K; Nimnual, Anjaruwee; Klip, Amira; Bar-Sagi, Dafna; Rozakis-Adcock, Maria
2002 Oct;22(20):7325-7336, Molecular & cellular biology
— id: 62937, year: 2002, vol: 22, page: 7325, stat: Journal Article,

The structural basis for the transition from Ras-GTP to Ras-GDP
Hall, Brian E; Bar-Sagi, Dafna; Nassar, Nicolas
2002 Sep 17;99(19):12138-12142, Proceedings of the National Academy of Sciences of the United States of America
— id: 62938, year: 2002, vol: 99, page: 12138, stat: Journal Article,

Autoinhibition of Sos by intramolecular interactions
Hall, Brian E; Yang, Shao-Song; Bar-Sagi, Dafna
2002 Jan 1;7:d288-d294, Frontiers in biosciences
— id: 62944, year: 2002, vol: 7, page: d288, stat: Journal Article,

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
Lei, Kui; Nimnual, Anjaruwee; Zong, Wei-Xing; Kennedy, Norman J; Flavell, Richard A; Thompson, Craig B; Bar-Sagi, Dafna; Davis, Roger J
2002 Jul;22(13):4929-4942, Molecular & cellular biology
— id: 62941, year: 2002, vol: 22, page: 4929, stat: Journal Article,

Direct coupling of the cell cycle and cell death machinery by E2F
Nahle, Zaher; Polakoff, Julia; Davuluri, Ramana V; McCurrach, Mila E; Jacobson, Matthew D; Narita, Masashi; Zhang, Michael Q; Lazebnik, Yuri; Bar-Sagi, Dafna; Lowe, Scott W
2002 Nov;4(11):859-864, Nature cell biology
— id: 62936, year: 2002, vol: 4, page: 859, stat: Journal Article,

The two hats of SOS
Nimnual, Anjaruwee; Bar-Sagi, Dafna
2002 Aug 13;2002(145):pe36-pe36, Science's STKE
— id: 62939, year: 2002, vol: 2002, page: pe36, stat: Journal Article,

A Ras by any other name
Bar-Sagi D
2001 Mar;21(5):1441-1443, Molecular & cellular biology
— id: 62950, year: 2001, vol: 21, page: 1441, stat: Journal Article,

Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
Epperly MW; Kagan VE; Sikora CA; Gretton JE; Defilippi SJ; Bar-Sagi D; Greenberger JS
2001 Aug 20;96(4):221-231, International journal of cancer
— id: 62946, year: 2001, vol: 96, page: 221, stat: Journal Article,

Rac1 mediates STAT3 activation by autocrine IL-6
Faruqi TR; Gomez D; Bustelo XR; Bar-Sagi D; Reich NC
2001 Jul 31;98(16):9014-9019, Proceedings of the National Academy of Sciences of the United States of America
— id: 62947, year: 2001, vol: 98, page: 9014, stat: Journal Article,

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
Hall BE; Yang SS; Boriack-Sjodin PA; Kuriyan J; Bar-Sagi D
2001 Jul 20;276(29):27629-27637, Journal of biological chemistry
— id: 62948, year: 2001, vol: 276, page: 27629, stat: Journal Article,

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling
Lu W; Gong D; Bar-Sagi D; Cole PA
2001 Oct;8(4):759-769, Molecular cell
— id: 62945, year: 2001, vol: 8, page: 759, stat: Journal Article,

Differential activation of the Rac pathway by Ha-Ras and K-Ras
Walsh AB; Bar-Sagi D
2001 May 11;276(19):15609-15615, Journal of biological chemistry
— id: 62949, year: 2001, vol: 276, page: 15609, stat: Journal Article,

Ras and Rho GTPases: a family reunion
Bar-Sagi D; Hall A
2000 Oct 13;103(2):227-238, Cell
— id: 62951, year: 2000, vol: 103, page: 227, stat: Journal Article,

Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein
Schaley J; O'Connor RJ; Taylor LJ; Bar-Sagi D; Hearing P
2000 Mar;74(5):2084-2093, Journal of virology
— id: 62955, year: 2000, vol: 74, page: 2084, stat: Journal Article,

Single cell assays for Rac activity
Taylor LJ; Walsh AB; Hearing P; Bar-Sagi D
2000 ;325:327-334, Methods in enzymology
— id: 62952, year: 2000, vol: 325, page: 327, stat: Journal Article,

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
Tournier C; Hess P; Yang DD; Xu J; Turner TK; Nimnual A; Bar-Sagi D; Jones SN; Flavell RA; Davis RJ
2000 May 5;288(5467):870-874, Science
— id: 62953, year: 2000, vol: 288, page: 870, stat: Journal Article,

Workshop on specificity in Ras and Rho-mediated signalling events
Bos JL; Lacal, Juan Carlos; Hall, A; Bar-Sagi, D
[Madrid] : Instituto Juan March de Estudios e Investigaciones, 1999,
— id: 2203, year: 1999, vol: , page: , stat: ,

Suppression of Ras-induced apoptosis by the Rac GTPase
Joneson T; Bar-Sagi D
1999 Sep;19(9):5892-5901, Molecular & cellular biology
— id: 62957, year: 1999, vol: 19, page: 5892, stat: Journal Article,

SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway
Kumar CC; Ohashi K; Nagata K; Walsh A; Bar-Sagi D; Mizuno K
1999 ;886:122-131, Annals of the New York Academy of Sciences
— id: 62954, year: 1999, vol: 886, page: 122, stat: Journal Article,

Nucleolar Arf sequesters Mdm2 and activates p53
Weber JD; Taylor LJ; Roussel MF; Sherr CJ; Bar-Sagi D
1999 May;1(1):20-26, Nature cell biology
— id: 62956, year: 1999, vol: 1, page: 20, stat: Journal Article,

Transmembrane signaling protocols
Bar-Sagi, Dafna
Totowa NJ : Humana Press, 1998,
— id: 1087, year: 1998, vol: , page: , stat: ,

The structural basis of the activation of Ras by Sos
Boriack-Sjodin PA; Margarit SM; Bar-Sagi D; Kuriyan J
1998 Jul 23;394(6691):337-343, Nature
— id: 62959, year: 1998, vol: 394, page: 337, stat: Journal Article,

Regulation of Sos activity by intramolecular interactions
Corbalan-Garcia S; Margarit SM; Galron D; Yang SS; Bar-Sagi D
1998 Feb;18(2):880-886, Molecular & cellular biology
— id: 62963, year: 1998, vol: 18, page: 880, stat: Journal Article,

A Rac1 effector site controlling mitogenesis through superoxide production
Joneson T; Bar-Sagi D
1998 Jul 17;273(29):17991-17994, Journal of biological chemistry
— id: 62960, year: 1998, vol: 273, page: 17991, stat: Journal Article,

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
Joneson T; Fulton JA; Volle DJ; Chaika OV; Bar-Sagi D; Lewis RE
1998 Mar 27;273(13):7743-7748, Journal of biological chemistry
— id: 62961, year: 1998, vol: 273, page: 7743, stat: Journal Article,

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
Nimnual AS; Yatsula BA; Bar-Sagi D
1998 Jan 23;279(5350):560-563, Science
— id: 62962, year: 1998, vol: 279, page: 560, stat: Journal Article,

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein
Soisson SM; Nimnual AS; Uy M; Bar-Sagi D; Kuriyan J
1998 Oct 16;95(2):259-268, Cell
— id: 62958, year: 1998, vol: 95, page: 259, stat: Journal Article,

The role of the PH domain in the signal-dependent membrane targeting of Sos
Chen RH; Corbalan-Garcia S; Bar-Sagi D
1997 Mar 17;16(6):1351-1359, EMBO journal
— id: 62967, year: 1997, vol: 16, page: 1351, stat: Journal Article,

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
Colley WC; Sung TC; Roll R; Jenco J; Hammond SM; Altshuller Y; Bar-Sagi D; Morris AJ; Frohman MA
1997 Mar 1;7(3):191-201, Current biology. CB
— id: 62968, year: 1997, vol: 7, page: 191, stat: Journal Article,

Ras effectors and their role in mitogenesis and oncogenesis
Joneson T; Bar-Sagi D
1997 Aug;75(8):587-593, Journal of molecular medicine (Berlin)
— id: 62966, year: 1997, vol: 75, page: 587, stat: Journal Article,

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
Kouhara H; Hadari YR; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J
1997 May 30;89(5):693-702, Cell
— id: 56961, year: 1997, vol: 89, page: 693, stat: Journal Article,

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway
Walsh AB; Dhanasekaran M; Bar-Sagi D; Kumar CC
1997 Nov 20;15(21):2553-2560, Oncogene
— id: 62965, year: 1997, vol: 15, page: 2553, stat: Journal Article,

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains
Zheng J; Chen RH; Corblan-Garcia S; Cahill SM; Bar-Sagi D; Cowburn D
1997 Nov 28;272(48):30340-30344, Journal of biological chemistry
— id: 62964, year: 1997, vol: 272, page: 30340, stat: Journal Article,

Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation
Corbalan-Garcia S; Degenhardt KR; Bar-Sagi D
1996 Mar 7;12(5):1063-1068, Oncogene
— id: 62973, year: 1996, vol: 12, page: 1063, stat: Journal Article,

Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2
Corbalan-Garcia S; Yang SS; Degenhardt KR; Bar-Sagi D
1996 Oct;16(10):5674-5682, Molecular & cellular biology
— id: 62970, year: 1996, vol: 16, page: 5674, stat: Journal Article,

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
Joneson T; McDonough M; Bar-Sagi D; Van Aelst L
1996 Nov 22;274(5291):1374-1376, Science
— id: 62969, year: 1996, vol: 274, page: 1374, stat: Journal Article,

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
Joneson T; White MA; Wigler MH; Bar-Sagi D
1996 Feb 9;271(5250):810-812, Science
— id: 62974, year: 1996, vol: 271, page: 810, stat: Journal Article,

The Ras superfamily of GTPases
Macara IG; Lounsbury KM; Richards SA; McKiernan C; Bar-Sagi D
1996 Apr;10(5):625-630, FASEB journal
— id: 62972, year: 1996, vol: 10, page: 625, stat: Journal Article,

Identification of a novel Rac1-interacting protein involved in membrane ruffling
Van Aelst L; Joneson T; Bar-Sagi D
1996 Aug 1;15(15):3778-3786, EMBO journal
— id: 62971, year: 1996, vol: 15, page: 3778, stat: Journal Article,

Mammalian cell microinjection assay
Bar-Sagi D
1995 ;255:436-442, Methods in enzymology
— id: 62977, year: 1995, vol: 255, page: 436, stat: Journal Article,

Purification of baculovirus-expressed human Sos1 protein
Frech M; Cussac D; Chardin P; Bar-Sagi D
1995 ;255:125-129, Methods in enzymology
— id: 62978, year: 1995, vol: 255, page: 125, stat: Journal Article,

Inhibition of ras-induced proliferation and cellular transformation by p16INK4
Serrano M; Gomez-Lahoz E; DePinho RA; Beach D; Bar-Sagi D
1995 Jan 13;267(5195):249-252, Science
— id: 62976, year: 1995, vol: 267, page: 249, stat: Journal Article,

Differential interactions of human Sos1 and Sos2 with Grb2
Yang SS; Van Aelst L; Bar-Sagi D
1995 Aug 4;270(31):18212-18215, Journal of biological chemistry
— id: 62975, year: 1995, vol: 270, page: 18212, stat: Journal Article,

The Sos (Son of sevenless) protein
Bar-Sagi, D
1994 May-Jun;5(4):165-169, Trends in endocrinology & metabolism
— id: 105531, year: 1994, vol: 5, page: 165, stat: Journal Article,

Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP
Boyer MJ; Gutmann DH; Collins FS; Bar-Sagi D
1994 Feb;9(2):349-357, Oncogene
— id: 62981, year: 1994, vol: 9, page: 349, stat: Journal Article,

An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane
Rotin D; Bar-Sagi D; O'Brodovich H; Merilainen J; Lehto VP; Canessa CM; Rossier BC; Downey GP
1994 Oct 3;13(19):4440-4450, EMBO journal
— id: 62980, year: 1994, vol: 13, page: 4440, stat: Journal Article,

Activation of Ras and other signaling pathways by receptor tyrosine kinases
Schlessinger J; Bar-Sagi D
1994 ;59:173-179, Cold Spring Harbor symposia on quantitative biology
— id: 56846, year: 1994, vol: 59, page: 173, stat: Journal Article,

Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
Sun H; Tonks NK; Bar-Sagi D
1994 Oct 14;266(5183):285-288, Science
— id: 62979, year: 1994, vol: 266, page: 285, stat: Journal Article,

SH3 domains direct cellular localization of signaling molecules
Bar-Sagi D; Rotin D; Batzer A; Mandiyan V; Schlessinger J
1993 Jul 16;74(1):83-91, Cell
— id: 35758, year: 1993, vol: 74, page: 83, stat: Journal Article,

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
Chardin P; Camonis JH; Gale NW; van Aelst L; Schlessinger J; Wigler MH; Bar-Sagi D
1993 May 28;260(5112):1338-1343, Science
— id: 62984, year: 1993, vol: 260, page: 1338, stat: Journal Article,

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
Gale NW; Kaplan S; Lowenstein EJ; Schlessinger J; Bar-Sagi D
1993 May 6;363(6424):88-92, Nature
— id: 62985, year: 1993, vol: 363, page: 88, stat: Journal Article,

Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event
Hide I; Bennett JP; Pizzey A; Boonen G; Bar-Sagi D; Gomperts BD; Tatham PE
1993 Nov;123(3):585-593, Journal of cell biology
— id: 62982, year: 1993, vol: 123, page: 585, stat: Journal Article,

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
Li N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J
1993 May 6;363(6424):85-88, Nature
— id: 57448, year: 1993, vol: 363, page: 85, stat: Journal Article,

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
Quelle DE; Ashmun RA; Shurtleff SA; Kato JY; Bar-Sagi D; Roussel MF; Sherr CJ
1993 Aug;7(8):1559-1571, Genes & development
— id: 62983, year: 1993, vol: 7, page: 1559, stat: Journal Article,

Mechanisms of signal transduction by Ras
Bar-Sagi D
1992 Apr;3(2):93-98, Seminars in cell biology
— id: 62986, year: 1992, vol: 3, page: 93, stat: Journal Article,

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein EJ; Daly RJ; Batzer AG; Li W; Margolis B; Lammers R; Ullrich A; Skolnik EY; Bar-Sagi D; Schlessinger J
1992 Aug 7;70(3):431-442, Cell
— id: 13480, year: 1992, vol: 70, page: 431, stat: Journal Article,

Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules
Portilla D; Mandel LJ; Bar-Sagi D; Millington DS
1992 Mar;262(3 Pt 2):F354-F360, American journal of physiology
— id: 62987, year: 1992, vol: 262, page: F354, stat: Journal Article,

Phospholipase A2: microinjection and cell localization techniques
Bar-Sagi D
1991 ;197:269-279, Methods in enzymology
— id: 62990, year: 1991, vol: 197, page: 269, stat: Journal Article,

Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake
Graziadei L; Burfeind P; Bar-Sagi D
1991 Apr;194(1):198-203, Analytical biochemistry
— id: 62989, year: 1991, vol: 194, page: 198, stat: Journal Article,

Association of p21ras with cellular polypeptides
Kaplan S; Bar-Sagi D
1991 Oct 5;266(28):18934-18941, Journal of biological chemistry
— id: 62988, year: 1991, vol: 266, page: 18934, stat: Journal Article,

Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes
Cockcroft S; Bar-Sagi D
1990 ;2(3):227-234, Cellular signalling
— id: 62992, year: 1990, vol: 2, page: 227, stat: Journal Article,

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes
Graziadei L; Riabowol K; Bar-Sagi D
1990 Sep 27;347(6291):396-400, Nature
— id: 62991, year: 1990, vol: 347, page: 396, stat: Journal Article,

ras proteins: biological effects and biochemical targets (review)
Bar-Sagi D
1989 Sep-Oct;9(5):1427-1437, Anticancer research
— id: 62993, year: 1989, vol: 9, page: 1427, stat: Journal Article,

G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2
Kim D; Lewis DL; Graziadei L; Neer EJ; Bar-Sagi D; Clapham DE
1989 Feb 9;337(6207):557-560, Nature
— id: 62994, year: 1989, vol: 337, page: 557, stat: Journal Article,

Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells
Bar-Sagi D; Gomperts BD
1988 Oct;3(4):463-469, Oncogene
— id: 62995, year: 1988, vol: 3, page: 463, stat: Journal Article,

Localization of phospholipase A2 in normal and ras-transformed cells
Bar-Sagi D; Suhan JP; McCormick F; Feramisco JR
1988 May;106(5):1649-1658, Journal of cell biology
— id: 62996, year: 1988, vol: 106, page: 1649, stat: Journal Article,

Regulation of membrane turnover by ras proteins
Bar-Sagi D; Fernandez A; Feramisco JR
1987 May;7(5):427-434, Bioscience reports
— id: 62997, year: 1987, vol: 7, page: 427, stat: Journal Article,

Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells
Bar-Sagi D; McCormick F; Milley RJ; Feramisco JR
1987 ;Suppl 5:69-73, Journal of cellular physiology. Supplement
— id: 62998, year: 1987, vol: Suppl 5, page: 69, stat: Journal Article,

Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins
Bar-Sagi D; Feramisco JR
1986 Sep 5;233(4768):1061-1068, Science
— id: 62999, year: 1986, vol: 233, page: 1061, stat: Journal Article,

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
Bar-Sagi D; Feramisco JR
1985 Oct;42(3):841-848, Cell
— id: 63000, year: 1985, vol: 42, page: 841, stat: Journal Article,

Negative modulation of sodium channels in cultured chick muscle cells by the channel activator batrachotoxin
Bar-Sagi D; Prives J
1985 Apr 25;260(8):4740-4744, Journal of biological chemistry
— id: 63001, year: 1985, vol: 260, page: 4740, stat: Journal Article,

Regulation of surface properties in cultured muscle cells
Bar-Sagi, Dafna
[S.l. : s.n.], 1984,
— id: 2082, year: 1984, vol: , page: , stat: ,

Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion
Bar-Sagi D; Prives J
1983 Nov;97(5 Pt 1):1375-1380, Journal of cell biology
— id: 63002, year: 1983, vol: 97, page: 1375, stat: Journal Article,

Tunicamycin inhibits the expression of surface Na+ channels in cultured muscle cells
Bar-Sagi D; Prives J
1983 Jan;114(1):77-81, Journal of cellular physiology
— id: 63005, year: 1983, vol: 114, page: