Mary Helen Barcellos-Hoff

Biosketch / Results /

Mary Helen Barcellos-Hoff, Ph.D.

Departments of Radiation Oncology (Radiation Oncology ) and Cell Biology (Cell Biology)

Contact Info

450 E. 29th Street
Floor 3rd Room 321
Alexandria Building
New York, NY 10016


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1986 — University of California, San Francisco (Experimental Pathology), Graduate Education
1986-1988 — University of California, Berkeley (Cell Bio and Biophysics), PostDoctoral Training

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Research Interests

The goal of our research is to understand how tissues integrate information across multiple scales of organization and to use this information in modeling critical events in carcinogenesis. We study ionizing radiation (IR), a prototypic carcinogen, in terms of its effects on cell phenotype and tissue interactions. Identifying when and how tissue alterations contribute to the action of IR may provide a means to inhibiting its carcinogenic potential, as well as a better understanding of how normal tissues suppress carcinogenesis. A major focus of my laboratory is to study the multiple and complex mechanisms by which transforming growth factor beta (TGFb) affects irradiated cells and tissues. The combined effects of TGFb and IR have profound effects on epithelial phenotype, centrosome regulation and genomic stability. We discovered that TGFb is activated in response to IR, which in turn revealed that TGFb is essential for epithelial cells to mount the canonical DNA damage response as shown by the failure of Tgfb1 null murine epithelial cells to undergo cell cycle arrest or apoptosis in response to irradiation. We showed that the abrogated DNA damage response is due to regulation of ATM kinase activity and can be phenocopied using small molecule TGFb inhibitors in human epithelial cells. The requirement for TGFb in the genotoxic stress program also provides a previously unsuspected avenue to modulate radiotherapy. Pharmaceutical means to inhibit TGFb are in clinical trials. We have translated our discovery that TGFb ensures effective response to DNA damage by testing TGFI? inhibitors in preclinical human and mouse models of breast, brain and lung cancer. TGFb inhibition in conjunction with radiotherapy increases sensitivity to clonogenic death and tumor growth delay. A direct and specific requirement for TGFb in the genotoxic stress program provides an important vital link between cell fate and tissue integrity and underscores the dynamic interaction between target cells and other cell types. We developed a radiation chimera model to test this idea. In this model the mice are irradiated, then transplanted with unirradiated oncogenically primed mammary epithelial cells. Radiation accelerated tumorigenesis but surprisingly also affects the type of tumor, promoting those that are more aggressive basal-like phenotype. This model offers novel insight into the carcinogenic process.

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All data from NYU Health Sciences Library Faculty Bibliography — -


Development of a novel multiplexed assay for quantification of transforming growth factor-beta (TGF-beta)
Pellicciotta, Ilenia; Marciscano, Ariel E; Hardee, Matthew E; Francis, Derek; Formenti, Silvia; Barcellos-Hoff, Mary Helen
2015 Jan;:1-13, Growth factors
— id: 1436282, year: 2015, vol: , page: 1, stat: Journal Article,

Photoactivation of Endogenous Latent Transforming Growth Factor-beta1 Directs Dental Stem Cell Differentiation for Regeneration
Arany, Praveen R; Cho, Andrew; Hunt, Tristan D; Sidhu, Gursimran; Shin, Kyungsup; Hahm, Eason; Huang, George X; Weaver, James; Chen, Aaron Chih-Hao; Padwa, Bonnie L; Hamblin, Michael R; Barcellos-Hoff, Mary Helen; Kulkarni, Ashok B; J Mooney, David
2014 May;6(238):238ra69-238ra69 238ra69, Science translational medicine
— id: 1018752, year: 2014, vol: 6, page: 238ra69, stat: Journal Article,

Systems biology perspectives on the carcinogenic potential of radiation
Barcellos-Hoff, Mary Helen; Adams, Cassandra; Balmain, Allan; Costes, Sylvain V; Demaria, Sandra; Illa-Bochaca, Irineu; Mao, Jian Hua; Ouyang, Haoxu; Sebastiano, Christopher; Tang, Jonathan
2014 Mar;55 Suppl 1:i145-i154, Journal of radiation research
— id: 829602, year: 2014, vol: 55 Suppl 1, page: i145, stat: Journal Article,

New tricks for an old fox: Impact of TGFbeta on the DNA damage response and genomic stability
Barcellos-Hoff, Mary Helen; Cucinotta, Francis A
2014 ;7(341):re5-re5 re5, Science signaling
— id: 1173842, year: 2014, vol: 7, page: re5, stat: Journal Article,

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature
Bassani, Luigi; Graffeo, Christopher S; Behrooz, Navid; Tyagi, Vineet; Wilson, Taylor; Penaranda, Saul; Zagzag, David; Rifkin, Daniel B; Barcellos-Hoff, Mary Helen; Fatterpekar, Girish; Placantonakis, Dimitris
2014 ;5:8-8, Surgical neurology international
— id: 820792, year: 2014, vol: 5, page: 8, stat: Journal Article,

Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53 Null Mammary Carcinomas
Illa-Bochaca, Irineu; Ouyang, Haoxu; Tang, Jonathan; Sebastiano, Christopher; Mao, Jian-Hua; Costes, Sylvain V; Demaria, Sandra; Barcellos-Hoff, Mary Helen
2014 Oct;:458-458, Cancer research
— id: 1300252, year: 2014, vol: , page: 458, stat: Journal Article,

Soil amendments that slow cancer growth
Isacke, Clare M; Barcellos-Hoff, Mary Helen
2014 Jun;4(6):637-639, Cancer discovery
— id: 1030892, year: 2014, vol: 4, page: 637, stat: Journal Article,

Distinct luminal type mammary carcinomas arise from orthotopic Trp53 null mammary transplantation of juvenile versus adult mice
Nguyen, David H; Ouyang, Haoxu; Mao, Jian-Hua; Hlatky, Lynn; Barcellos-Hoff, Mary Helen
2014 Oct;:1784-1784, Cancer research
— id: 1283232, year: 2014, vol: , page: 1784, stat: Journal Article,

Irradiation of Juvenile, but not Adult, Mammary Gland Increases Stem Cell Self-Renewal and Estrogen Receptor Negative Tumors
Tang, Jonathan; Fernandez-Garcia, Ignacio; Vijayakumar, Sangeetha; Martinez-Ruis, Haydeliz; Illa-Bochaca, Irineu; Nguyen, David H; Mao, Jian-Hua; Costes, Sylvain V; Barcellos-Hoff, Mary Helen
2014 Mar;32(3):649-661, Stem cells
— id: 829982, year: 2014, vol: 32, page: 649, stat: Journal Article,

TGF-beta1 Protects Cells from Gamma-IR by Enhancing the Activity of the NHEJ Repair Pathway
Yi, Jae Youn; Kim, Mi-Ra; Lee, Jeeyong; An, You Sun; Jin, Yeong Bae; Park, In-Chul; Chung, Eunkyung; Shin, Incheol; Barcellos-Hoff, Mary Helen
2014 Oct;:663-671, Molecular cancer research
— id: 1310212, year: 2014, vol: , page: 663, stat: Journal Article,

Breast cancer risk in BRCA1 mutation carriers: insight from mouse models
Barcellos-Hoff, M H; Kleinberg, D L
2013 Nov;24 Suppl 8:viii8-viii12, Annals of oncology
— id: 598512, year: 2013, vol: 24 Suppl 8, page: viii8, stat: Journal Article,

Radiation-induced TGF beta suppresses immune cells in the tumor microenvironment
Barcellos-Hoff, M. H.; Pelliccotta, I.; Du, S.; Formenti, S. C.
2013 SEP;49 2 2:S12-S12, European journal of cancer (1990)
— id: 667392, year: 2013, vol: 49 2 2, page: S12, stat: Journal Article,

Biologically Augmenting Radiation Therapy by Inhibiting TGF beta in NSCLC from Molecular to Microenvironment
Du, S. ; Pellicciotta, I. ; Barcellos-Hoff, M.
2013 OCT 1;87(2 S S):S139-S140, International journal of radiation oncology biology physics
— id: 656672, year: 2013, vol: 87, page: S139, stat: Journal Article,

Biologically augmenting radiation therapy by inhibiting tgfbeta in NSCLC from molecular to microenvironment
Du, S; Pellicciotta, I; Barcellos-Hoff, M
2013 01 Oct 2013;87(2):S139- S140, International journal of radiation oncology biology physics
— id: 602572, year: 2013, vol: 87, page: S139, stat: Journal Article,

Tumors as Organs: Biologically Augmenting Radiation Therapy by Inhibiting Transforming Growth Factor beta Activity in Carcinomas
Du, Shisuo; Barcellos-Hoff, Mary Helen
2013 Oct;23(4):242-251, Seminars in radiation oncology
— id: 529112, year: 2013, vol: 23, page: 242, stat: Journal Article,

Paclitaxel Enhances the Immunogenic Signature of Radiation
Golden, E. B. ; Demaria, S. ; Barcellos-Hoff, M. ; Formenti, S. C.
2013 OCT 1;87(2 S S):S634-S634, International journal of radiation oncology biology physics
— id: 656642, year: 2013, vol: 87, page: S634, stat: Journal Article,

Radiation Promotes a Dose-Response Induction of Immunogenic Cell Death
Golden, E. B. ; Demaria, S. ; Barcellos-Hoff, M. ; Formenti, S. C.
2013 OCT 1;87(2 S S):S633-S633, International journal of radiation oncology biology physics
— id: 657472, year: 2013, vol: 87, page: S633, stat: Journal Article,

The Immunogenic Signature of Platinum and Radiation
Golden, E. B. ; Demaria, S. ; Barcellos-Hoff, M. ; Formenti, S. C.
2013 OCT 1;87(2 S S):S629-S629, International journal of radiation oncology biology physics
— id: 656432, year: 2013, vol: 87, page: S629, stat: Journal Article,

Igf-I inhibition by pasireotide reverses the mammary phenotype of a novel mouse model of Brca1 deficiency
Ameri, P; Fernandez-Garcia, I; Martinez-Ruiz, H; De, Angelis C; Barcellos-Hoff, M H; Kleinberg, D L
2012 June 2012;33(3):-, Endocrine reviews
— id: 175839, year: 2012, vol: 33, page: , stat: Journal Article,

Inhibition of IGF-1 suppress genomic instability and epithelial lineage aberrations in the mammary gland of BRCA1 deficient mice
Fernandez-Garcia, I; Ameri, P; Barcellos-Hoff, M H; Kleinberg, D L
2012 15 Apr 2012;72(8):-, Cancer research
— id: 422462, year: 2012, vol: 72, page: , stat: Journal Article,

Radiation and endoplasmic reticulum stress-inducer promote calreticulin translocation, contributing to immunogenic cell death of cancer cells
Golden E.; Demaria S.; Barcellos-Hoff M.H.
2012 ;35(1):100-100, Journal of immunotherapy (Hagerstown)
— id: 149974, year: 2012, vol: 35, page: 100, stat: Journal Article,

TGFbeta is a master regulator of the pro-immunogenic effects of radiotherapy
Vanpouille-Box, C; Pilones, K A; Bouquet, S; Zavadil, J; Formenti, S; Barcellos-Hoff, M -H; Demaria, S
2012 November-December 2012;35(9):734-735, Journal of immunotherapy (Hagerstown)
— id: 185442, year: 2012, vol: 35, page: 734, stat: Journal Article,

In honor of Mina J. Bissell
Barcellos-Hoff, Mary Helen
2011 Apr 1;3(4):253-254, Integrative biology
— id: 130303, year: 2011, vol: 3, page: 253, stat: Journal Article,

TGFbeta Biology in Breast: 15 Years On
Barcellos-Hoff, Mary Helen
2011 Jun;16(2):65-66, Journal of mammary gland biology & neoplasia
— id: 132582, year: 2011, vol: 16, page: 65, stat: Journal Article,

Low-dose radiation knowledge worth the cost
Barcellos-Hoff, Mary Helen; Brenner, David J; Brooks, Antone L; Formenti, Silvia; Hlatky, Lyn; Locke, Paul A; Shore, Roy; Tenforde, Thomas; Travis, Elizabeth L; Williams, Jacqueline
2011 Apr 15;332(6027):305-306, Science
— id: 140490, year: 2011, vol: 332, page: 305, stat: Journal Article,

Increased radiosensitivity in vivo following inhibition of transforming growth factor beta in murine model of triple negative breast cancer
Bouquet S.F.; Pilones K.; Demaria S.; DeWyngaert K.J.; Lonning S.; Formenti S.; Barcellos-Hoff M.
2011 ;81:S714-S715, International journal of radiation oncology biology physics
— id: 150891, year: 2011, vol: 81, page: S714, stat: Journal Article,

TGFbeta inhibition radiosensitizes murine glioblastoma cells and decreases neurosphere-forming capacity
Hardee M.E.; Marciscano A.E.; Zagzag D.; Narayana A.; Barcellos-Hoff M.
2011 ;81(2 SUPPL 1):S714-S714, International journal of radiation oncology biology physics
— id: 150892, year: 2011, vol: 81, page: S714, stat: Journal Article,

Multiplicity of Favorable Effects after Transforming Growth Factor-beta Inhibition in 4T1 Murine Mammary Tumors: Clinical Implications
Barcellos-Hoff, M. H.; Bouquet, S. F.; Pilones, K. A.; Demaria, S.; Formenti, S. C.
2010 OCT 13 ;78(3):S648-S648, International journal of radiation oncology biology physics
— id: 114022, year: 2010, vol: 78, page: S648, stat: Journal Article,

Microenvironment and cell fate determination in MCF10A is mediated by ionizing radiation, TGFbeta and the extracellular matrix
Fernandez-Garcia, I; Paupert, J; Barcellos-Hoff, M
2010 15 Dec 2010;21(24):-, Molecular biology of the cell
— id: 157725, year: 2010, vol: 21, page: , stat: Journal Article,

The development of integrative biology: bridging the gap--a view from the Scientific Editors. [An interview with David Beebe and Mary Helen Barcellos-Hoff by Kathleen Too]
Beebe, David; Barcellos-Hoff, Mary Helen
2009 Feb;1(2):145-147, Integrative biology
— id: 116248, year: 2009, vol: 1, page: 145, stat: Journal Article,

Host biology affects the frequency of ER plus breast cancer
Nguyen, David; Oketch-Rabah, Hellen; Barcellos-Hoff, Mary Helen
2009 ;50(Suppl. S):577-577, Proceedings (American Association for Cancer Research)
— id: 104661, year: 2009, vol: 50, page: 577, stat: Journal Article,

Persistent phenotypic responses of human mammary epithelial cells induced by ionizing radiation
Andarawewa K.L.; Chou W.S.; Costes S.V.; Barcellos-Hoff M.H.
2008 ;53(SUPPL.):61-63, Acta medica Nagasakiensia
— id: 99261, year: 2008, vol: 53, page: 61, stat: Journal Article,

Bioavailability of TGF-beta in breast cancer
Barcellos-Hoff, Mary H; Bochaca, Irineu I
Ft. Belvoir VA : Defense Technical Information Center, 2008,
— id: 2092, year: 2008, vol: , page: , stat: ,

The genomic differences in radiated breast - Epithelial cells is centrosome given - Implication for the increased risk during continually radiated breast cancer
Fleisch, MC; Maxwell, CA; Costes, SV; Barcellos-Hoff, MH
2008 ;68(20):S104-S104, Geburtshilfe & Frauenheilkunde
— id: 104664, year: 2008, vol: 68, page: S104, stat: Journal Article,

Inhibition of transforming growth factor betal (TGF beta 1) signaling increases radiosensitivity in breast cancer cell lines
Pal, Anupama; Gascard, Philippe D.; Ravani, Shraddha A.; Barcellos-Hoff, Mary Helen
2008 ;49(1):98-98, Proceedings (American Association for Cancer Research)
— id: 104663, year: 2008, vol: 49, page: 98, stat: Journal Article,

Radiation therapy and the microenvironment
Barcellos-Hoff, Mary Helen; Cordes, Nils
2007 Nov-Dec;83(11-12):723-725, International journal of radiation biology
— id: 83250, year: 2007, vol: 83, page: 723, stat: Journal Article,

Perceptual grouping of membrane signals in cell-based assays
Chang, H.; Andarawewa, K.L.; Han, J.; Barcellos-Hoff, M.H.; Parvin, B.
2007 4th IEEE International Symposium on Biomedical Imaging: Macro to Nano Piscataway, N.J. : IEEE, 2007,
— id: 5226, year: 2007, vol: , page: 532, stat: Chapter,

Segmentation of mammosphere structures from volumetric data
Ju Han; Hang Chang; Qing Yang; Barcellos-Hoff , M.H.; Parvin, B.
2007 4th IEEE International Symposium on Biomedical Imaging from nano to macro : proceedings Piscataway, N.J. : IEEE, 2007,
— id: 5227, year: 2007, vol: , page: 524, stat: Chapter,

Response of a human breast cell line to transforming growth factor-beta (TGF-beta) is context specific and involves components of TGF-beta and the epidermal growth factor receptor signaling pathways
Mott, Joni D.; Barcellos-Hoff, Mary Helen
2007 ;48(18):896-896, Proceedings (American Association for Cancer Research)
— id: 104666, year: 2007, vol: 48, page: 896, stat: Journal Article,

Persistent activation of Erk in the progeny of irradiated human mammary epithelial cells during TGF beta-induced epithelial to mesenchymal transition
Andarawewa, Kumari L.; Erickson, Anna C.; Chou, William S.; Barcellos-Hoff, Mary Helen
2006 ;47(1):651-651, Proceedings (American Association for Cancer Research)
— id: 104668, year: 2006, vol: 47, page: 651, stat: Journal Article,

Multicellular and multigenerational responses to TGF beta
Barcellos-Hoff, MH
2006 ;27(1-2):32-32, Tumour biology
— id: 104669, year: 2006, vol: 27, page: 32, stat: Journal Article,

Loss of TGF-beta promotes accumulation of centrosome amplification and karyotypic abnormalities in p53 competent mammary cells and tissues
Fleisch, MC; Maxwell, CA; Kuper, CK; Costes, SV; Barcellos-Hoff, MH
2006 ;100(12):S290-S291, Breast cancer research & treatment
— id: 104670, year: 2006, vol: 100, page: S290, stat: Journal Article,

3D segmentation of mammospheres for localization studies
Ju Han; Hang Chang; Qing Yang; Barcellos-Hoff, M.H.; Parvin, B.
Advances in visual computing : second international symposium, ISVC 2006, Lake Tahoe, NV, USA, November 6-8, 2006 : proceedings New York : Springer, 2006,
— id: 5228, year: 2006, vol: , page: 518, stat: Chapter,

A tool for the quantitative spatial analysis of heterogeneous cell populations
Fernandez-Gonzalez, Rodrigo; Ortiz de Solorzano, Carlos; Barcellos-Hoff, Mary Helen
2005 ;46(2):384-385, Proceedings (American Association for Cancer Research)
— id: 104671, year: 2005, vol: 46, page: 384, stat: Journal Article,

Targeting cell-extracellular matrix (ECM) interactions to enhance radiation efficacy for breast cancer treatment
Park, Catherine C.; Zhang, Hui J.; Yao, Evelyn; Barcellos-Hoff, Mary Helen; Bissell, Mina J.
2005 ;46(43):390-391, Proceedings (American Association for Cancer Research)
— id: 104673, year: 2005, vol: 46, page: 390, stat: Journal Article,

Geometric approach to segmentation and protein localization in cell cultured assays
Raman, S; Parvin, B; Maxwell, C; Barcellos-Hoff, MH
2005 ;3804(43):427-436, Medical image computing & computer-assisted intervention : MICCAI
— id: 104674, year: 2005, vol: 3804, page: 427, stat: Journal Article,

Localization of saliency through iterative voting
Qing Yang; Parvin, B.; Barcellos-Hoff, M.H.
Proceedings of the 17th International Conference on Pattern Recognition : ICPR 2004 Los Alamitos, Calif. : IEEE Computer Society Press, 2004,
— id: 5229, year: 2004, vol: , page: 63, stat: Chapter,

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
Stone, Helen B; Moulder, John E; Coleman, C Norman; Ang, K Kian; Anscher, Mitchell S; Barcellos-Hoff, Mary Helen; Dynan, William S; Fike, John R; Grdina, David J; Greenberger, Joel S; Hauer-Jensen, Martin; Hill, Richard P; Kolesnick, Richard N; Macvittie, Thomas J; Marks, Cheryl; McBride, William H; Metting, Noelle; Pellmar, Terry; Purucker, Mary; Robbins, Mike E; Schiestl, Robert H; Seed, Thomas M; Tomaszewski, Joseph E; Travis, Elizabeth L; Wallner, Paul E; Wolpert, Mary; Zaharevitz, Daniel
2004 Dec;162(6):711-728, Radiation research
— id: 83189, year: 2004, vol: 162, page: 711, stat: Journal Article,

The role of TGF-beta in radiation responses
Barcellos-Hoff, M. H.
2003 ;1(5):S227-S227, EJC Supplements
— id: 104677, year: 2003, vol: 1, page: S227, stat: Journal Article,

Radiation-induced versus endogenous DNA damage: commentary on Pollycove and Feinendegen
Barcellos-Hoff, MH
2003 ;22(6):307-307, Human & experimental toxicology
— id: 104676, year: 2003, vol: 22, page: 307, stat: Journal Article,

Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003
Coleman, C Norman; Stone, Helen B; Alexander, George A; Barcellos-Hoff, Mary Helen; Bedford, Joel S; Bristow, Robert G; Dynlacht, Joseph R; Fuks, Zvi; Gorelic, Lester S; Hill, Richard P; Joiner, Michael C; Liu, Fei-Fei; McBride, William H; McKenna, W Gillies; Powell, Simon N; Robbins, Michael E C; Rockwell, Sara; Schiff, Peter B; Shaw, Edward G; Siemann, Dietmar W; Travis, Elizabeth L; Wallner, Paul E; Wong, Rosemary S L; Zeman, Elaine M
2003 Dec;160(6):729-737, Radiation research
— id: 83174, year: 2003, vol: 160, page: 729, stat: Journal Article,

"Radiation-induced p53 Ser-18 phosphorylation is TGF-beta1 dependent in primary epithelial, but not fibroblast, cells"
Pajares, Maria J.; Glick, Adam; Jobling, Michael F.; Barcellos-Hoff, Mary Helen
2003 ;44(1):465-465, Proceedings (American Association for Cancer Research)
— id: 104679, year: 2003, vol: 44, page: 465, stat: Journal Article,

Transforming growth factor beta1 mediates radiation-induced apoptosis and p53 response in situ
Barcellos-Hoff, Mary H.; Henshall-Powell, Rhonda; Ewan, Kenneth B.; Ravani, Shraddha A.; Arteaga, Carlos; Akhurst, Rosemary; Warters, Ray; Parvin, Bahram
2002 ;43(4):147-147, Proceedings (American Association for Cancer Research)
— id: 104680, year: 2002, vol: 43, page: 147, stat: Journal Article,

Redox-mediated TGFbeta activation: Site specific oxidation of TGFbeta1
Jobling, Michael; Ledbetter, Steven; Finnigan, Monica; Lawrence, Cathy; Barcellos-Hoff, Mary Helen
2002 ;43(6):385-385, Proceedings (American Association for Cancer Research)
— id: 104683, year: 2002, vol: 43, page: 385, stat: Journal Article,

Microscopy environment for quantitative spatial and temporal analysis of multicellular interactions
Sudar, D; Parvin, B; Callahan, DE; Schwarz, RI; Knowles, DW; de Solorzano, CO; Barcellos-Hoff, MH
Three-dimensional and multidimensional microscopy : image acquisition and processing IX Bellingham, WA : SPIE, 2002,
— id: 5230, year: 2002, vol: , page: 47, stat: Chapter,

Epigenetics and breast cancer
Asch, B B; Barcellos-Hoff, M H
2001 Apr;6(2):151-152, Journal of mammary gland biology & neoplasia
— id: 83134, year: 2001, vol: 6, page: 151, stat: Journal Article,

Epigenetic mechanisms controlling gene expression in breast cancer
Asch, Bonnie B; Barcellos-Hoff, Mary Helen
New York NY : Kluwer Academic/Plenum, 2001,
— id: 2094, year: 2001, vol: , page: , stat: ,

Progesterone receptor signaling controls MMP activities in mouse mammary glands
Simian, M; Barcellos-Hoff, MH; Bissell, MJ; Harris, GS
2001 ;12(1):1090-1090, Molecular biology of the cell
— id: 104685, year: 2001, vol: 12, page: 1090, stat: Journal Article,

Low-dose ionizing radiation and transforming growth factor-beta (TGF-beta) are synergistic in altering interactions of human mammary epithelial cells with basement membrane (BM) cultured in a 3-dimensional (3D) matrix
Park, Catherine C.; Wang, Fei; Bissell, Mina J.; Barcellos-Hoff, Mary Helen
2000 ;6(41):376-376, Proceedings (American Association for Cancer Research)
— id: 104688, year: 2000, vol: 6, page: 376, stat: Journal Article,

BioSig: a bioinformatic system for studying the mechanism of inter-cell signaling
Parvin, B.; Cong, G.; Fontenay, G.; Taylor, J.; Henshall, R.; Barcellos-Hoff, M.H.
IEEE International Symposium on Bio-Informatics and Biomedical Engineering Los Alamitos, Ca. : IEEE Computer Society, 2000,
— id: 5231, year: 2000, vol: , page: ?, stat: Chapter,

Modification of multiple pathways revert the malignant phenotype of metastatic mammary carcinoma cells MDA-MB-231
Wang, Fei; Boudreau, Rosanne M.; Yoneda, Toshiyuki; Barcellos-Hoff, Mary Helen; Bissell, Mina J.
2000 ;6(41):473-473, Proceedings (American Association for Cancer Research)
— id: 104689, year: 2000, vol: 6, page: 473, stat: Journal Article,

Combinatorial modifications of multiple pathways reverts the malignant phenotype or mammary carcinoma cells MDA-MB-231
Wang, F; Yoneda, T; Barcellos-Hoff, MH; Bissell, MJ
1999 ;10(9):2024-2024, Molecular biology of the cell
— id: 104691, year: 1999, vol: 10, page: 2024, stat: Journal Article,

Carcinogen-induced microenvironment in breast cancer
Barcellos-Hoff, Mary
[S.l. : University of California at Berkeley, 1998,
— id: 2091, year: 1998, vol: , page: , stat: ,

A monoclonal antibody for 3-nitrotyrosine: Protein nitration is elevated in liver nonparenchymal cells
Shigenaga, MK; Girault, I; Karu, AE; Barcellos-Hoff, MH; Ames, BN
1998 ;25(5):187-187, Free radical biology & medicine
— id: 104692, year: 1998, vol: 25, page: 187, stat: Journal Article,

Activation of latent transforming growth factor-beta1 by oxidative and nirosative stress: Role of heme, nitroxyl anion, and nitric oxide
Vodovotz, Y.; Chesler, L.; Simpson, J. L.; Chong, H.; Kim, S.-J.; Cox, G.; Degraff, W.; Roberts, A. B.; Barcellos-Hoff, M. H.; Wink, D. A.
1998 ;2(2):114-114, Nitric oxide : biology & chemistry
— id: 104693, year: 1998, vol: 2, page: 114, stat: Journal Article,

Ionizing radiation accelerates aortic lesion formation in fat-fed mice via a mechanism that is inhibited by overexpression of Cu/Zn superoxide dismutase
Tribble, Diane L.; Barcellos-Hoff, Mary H.; Rubin, Edward M.; Leeuwenburgh, Christian; Heinecke, Jay W.; Gong, Elaine L.
1997 ;96(8 SUPPL.):I416-I416, Circulation
— id: 104695, year: 1997, vol: 96, page: I416, stat: Journal Article,

Effects of nitric oxide on the production of transforming growth factor beta-1 by tumor cells
Chesler, Louis; Cox, George; Barcellos-Hoff, Mary Helen; Wolf, Jeffrey; Takeguchi, Heather; Roberts, Anita; Kim, Seong-Jin; Vodovotz, Yoram
1996 ;37(0):42-43, Proceedings (American Association for Cancer Research)
— id: 104696, year: 1996, vol: 37, page: 42, stat: Journal Article,

TGF-beta activation in situ: Role in extracellular matrix remodeling
Ehrhart, E. J.; Segarini, P.; Tsang, M. L.-S.; Barcellos-Hoff, M. H.
1996 ;7(SUPPL.):410A-410A, Molecular biology of the cell
— id: 104697, year: 1996, vol: 7, page: 410A, stat: Journal Article,

1995 ;9(3):A125-A125, FASEB journal
— id: 104698, year: 1995, vol: 9, page: A125, stat: Journal Article,

Multicellular reorganization by single cells on extracellular matrix
Barcellos-Hoff, M. H.
1994 ;30A(3 PART 2):48-48, In vitro cellular & developmental biology. Animal
— id: 104699, year: 1994, vol: 30A, page: 48, stat: Journal Article,

Redox mechanism for activation of latent TGF-beta
Barcellos-Hoff, M. H.
1994 ;5(SUPPL.):139A-139A, Molecular biology of the cell
— id: 104700, year: 1994, vol: 5, page: 139A, stat: Journal Article,

Immunohistochemical discrimination of active versus latent TGF beta in situ
Barcellos-Hoff, M. H.
1993 ;4(SUPPL.):294A-294A, Molecular biology of the cell
— id: 104701, year: 1993, vol: 4, page: 294A, stat: Journal Article,

Development and functional differentiation of cultured mammary epithelial cells
Aggeler, Judith; Barcellos-Hoff, Mary Helen; Bissell, Mina J.
1992 ;4(SUPPL.):21-33, Contemporary issues in clinical nutrition
— id: 104702, year: 1992, vol: 4, page: 21, stat: Journal Article,

1992 ;4(16 PART F):78-78, Journal of cellular biochemistry. Supplement
— id: 104703, year: 1992, vol: 4, page: 78, stat: Journal Article,

1990 ;111(5 PART 2):12A-12A, Journal of cell biology
— id: 104706, year: 1990, vol: 111, page: 12A, stat: Journal Article,

1990 ;99(14 PART A):71-71, Journal of cellular biochemistry. Supplement
— id: 104705, year: 1990, vol: 99, page: 71, stat: Journal Article,

1988 ;107(6 PART 3):795A-795A, Journal of cell biology
— id: 104707, year: 1988, vol: 107, page: 795A, stat: Journal Article,

1987 ;105(4 PART 2):220A-220A, Journal of cell biology
— id: 104708, year: 1987, vol: 105, page: 220A, stat: Journal Article,

1987 ;105(4 PART 2):139A-139A, Journal of cell biology
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Cycling and noncycling cancer cells : expression of differential sensitivity to 1,3 bis(2-chloroethyl)-1-nitrosourea (BCNU) and X-rays
Barcellos-Hoff, Mary Helen
[S.l. : s.n.], 1986,
— id: 2093, year: 1986, vol: , page: , stat: ,

1986 ;27(4 PART 2):386-386, Proceedings (American Association for Cancer Research)
— id: 104710, year: 1986, vol: 27, page: 386, stat: Journal Article,

1985 ;101(5 PART 2):322A-322A, Journal of cell biology
— id: 104711, year: 1985, vol: 101, page: 322A, stat: Journal Article,