Irina Barash

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Irina Barash, M.D., M.S.

Assistant Professor;
Department of Medicine (Nephro Div)
NYU Langone Medical Center Nephrology Faculty Group Practice

Clinical Addresses

530 FIRST AVENUE, SKIRBALL 9U
SILVERSTEIN ELEVATORS
NEW YORK, NY 10016
Hours: Fri. 9 - 6
Handicap Access: yes
Phone: 212-263-5851

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Medical Specialties

Nephrology

Medical Expertise

Polycystic Kidney Disease, Hereditary Renal Disease

Clinical Responsibilities

Irina Barash M.D., M.S., B.A. Clinical Instructor / Skirball Institute Program of Molecular Pathogenesis / Member of NYU Nephrology Faculty Group Practice / Member of NYU Dialysis Associates / Department of Medicine Departments of Medicine (Nephrology) Member of NYU Nephrology Faculty Group Practice

Languages

Russian

Insurance

AETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, AFFINITY, AFFINITY EXCHANGE- ESSENTIAL, Cigna HMO/POS, Cigna PPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS POS, EBCBS PPO, FIDELIS CHLD HLTH, FIDELIS EXCHANGE, FIDELIS FAM HLTH, FIDELIS MEDICARE, Fidelis Medicaid, GHI CBP, HEALTHREPUBLIC, HIP ACCESS I, HIP ACCESS II, HIP CHLD HLTH, HIP EPO/PPO, HIP FAM HLTH, HIP HMO, HIP MEDICAID, HIP MEDICARE, HIP POS, LOCAL 1199 PPO, MAGNACARE PPO, METROPLUS CHLD HLTH, METROPLUS EXCHANGE PLANS, METROPLUS FAM HLTH, MULTIPLAN/PHCS PPO, Medicare, MetroPlus Medicaid, NY MEDICAID, NYS EMPIRE PLAN, OSCAR, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, Tricare, UHC EPO, UHC HMO UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS

Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.

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Board Certification

2005 — Ab Internal Medicine - Internal Medicine
2007 — Ab Internal Medicine (Nephrology)

Education

1998-2002 — SUNY Health Science Center, Medical Education
2002-2003 — Mount Sinai Hospital (Internal Medicine), Internship
2003-2005 — Mount Sinai Hospital (Internal Medicine), Residency Training
2005-2008 — Mount Sinai Medical Center (Nephrology), Clinical Fellowships

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Research Summary

Autosomal dominant polycystic kidney disease (ADPKD) is the most common, lethal, human genetic disease inherited as a dominant trait as a result of mutation in a single gene. With an estimated prevalence of 1:750, it affects over 600,000 individuals in the United States. In recent years, substantial progress has been made towards understanding the molecular genetics and biology of this disease that now makes it possible to design translational studies to improve prognosis and therapies for this group of patients. We are interested in pre-clinical testing of glycogen synthase kinase-3 beta inhibitors in polycystic kidney disease models to slow cyst progression. We have recently completed a pilot study of Water Loading in ADPKD and its effect on urine cyclic AMP (cAMP). Several labs have elucidated the importance of cAMP as the cell signal that drives cyst growth. Water loading, by suppressing vasopressin hormone levels and decreasing renal cell cAMP, dramatically reduced cyst size in animal models of PKD. We have now performed the first human study of water loading in ADPKD (Barash I, et al, Clin. J. Am. Soc. Nephrol., 5:693, 2010). We showed that acute water loading significantly reduces urine cAMP. While chronic water loading (over 1 week) did not significantly reduce urine cAMP levels, those with high baseline urine cAMP levels experienced the most reduction. Water loading as therapy for ADPKD deserves further consideration in larger clinical trials and with hard renal outcomes, such as total kidney volume and GFR change. Urine cAMP may be further explored as a potential disease biomarker and a complementary surrogate to urine osmolality in ADPKD patients. Our clinical studies include polycystic kidney disease patient database for longitudinal studies of impact of various clinical variables on disease progression; biomarker analysis to monitor disease progression and response to therapies; as well as clinical trials of therapies as they become available. We are currently participating in a world-wide multi-center clinical trial of an investigational drug safety and effectiveness in ADPKD as compared to placebo.

Research Interests

Pre-clinical testing and Clinical trials in Polycystic Kidney Disease

[Video: NYU physicians and researchers join with patients to fight ADPKD]

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Intraobserver and Interobserver Variability of Renal Volume Measurements in Polycystic Kidney Disease Using a Semiautomated MR Segmentation Algorithm
Cohen, Benjamin A; Barash, Irina; Kim, Danny C; Sanger, Matthew D; Babb, James S; Chandarana, Hersh
2012 Aug;199(2):387-393, American journal of roentgenology
— id: 174087, year: 2012, vol: 199, page: 387, stat: Journal Article,

Is Renal Thrombotic Angiopathy a Potential Problem in the Chronic Treatment of Ovarian Cancer?
Kwa, Maryann; Baumgartner, Robert; Shavit, Linda; Barash, Irina; Michael, Jeffrey; Puzanov, Igor; Kopolovic, Juri; Rosengarten, Ora; Blank, Stephanie; Curtin, John P; Gabizon, Alberto; Muggia, Franco
2012 May;:1534-1540, Oncologist
— id: 174215, year: 2012, vol: , page: 1534, stat: Journal Article,

A Pilot Clinical Study to Evaluate Changes in Urine Osmolality and Urine cAMP in Response to Acute and Chronic Water Loading in Autosomal Dominant Polycystic Kidney Disease
Barash, Irina; Ponda, Manish P; Goldfarb, David S; Skolnik, Edward Y
2010 Apr;5(4):693-697, Clinical journal of the American Society of Nephrology : CJASN
— id: 107297, year: 2010, vol: 5, page: 693, stat: Journal Article,

Moderate kidney disease inhibits atherosclerosis regression
Ponda, Manish P; Barash, Irina; Feig, Jonathan E; Fisher, Edward A; Skolnik, Edward Y
2010 May;210(1):57-62, Atherosclerosis
— id: 109717, year: 2010, vol: 210, page: 57, stat: Journal Article,

Lipid Metabolism in Dialysis Patients-The Story Gets More Complicated
Ponda, Manish P; Barash, Irina
2008 Sep-Oct;21(5):390-394, Seminars in dialysis
— id: 83347, year: 2008, vol: 21, page: 390, stat: Journal Article,

Chronic kidney disease in HIV infection: an urban epidemic
Wyatt, Christina M; Winston, Jonathan A; Malvestutto, Carlos D; Fishbein, Dawn A; Barash, Irina; Cohen, Alan J; Klotman, Mary E; Klotman, Paul E
2007 Oct 1;21(15):2101-2103, AIDS
— id: 109718, year: 2007, vol: 21, page: 2101, stat: Journal Article,